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Entry version 246 (08 May 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Insulin

Gene

INS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-16190

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-264876 Insulin processing
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
R-HSA-422356 Regulation of insulin secretion
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-77387 Insulin receptor recycling
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-977225 Amyloid fiber formation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P01308

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01308

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6081 INS

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176730 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01308

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperproinsulinemia (HPRI)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant condition characterized by elevated levels of serum proinsulin-like material.
See also OMIM:616214
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00397134H → D in HPRI; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918101EnsemblClinVar.1
Natural variantiVAR_00397489R → H in HPRI; impairs post-translational cleavage. 2 PublicationsCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_00397589R → L in HPRI; Kyoto. 1 PublicationCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Diabetes mellitus, insulin-dependent, 2 (IDDM2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125852
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06373255R → C in IDDM2. 1 PublicationCorresponds to variant dbSNP:rs121908261EnsemblClinVar.1
Diabetes mellitus, permanent neonatal (PNDM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
See also OMIM:606176
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06372324A → D in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356663EnsemblClinVar.1
Natural variantiVAR_06372429H → D in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908272EnsemblClinVar.1
Natural variantiVAR_06372532G → R in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372632G → S in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372735L → P in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908273EnsemblClinVar.1
Natural variantiVAR_06372843C → G in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356666EnsemblClinVar.1
Natural variantiVAR_06373047G → V in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356667EnsemblClinVar.1
Natural variantiVAR_06373148F → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_06373484G → R in PNDM; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121908274EnsemblClinVar.1
Natural variantiVAR_06373589R → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356669EnsemblClinVar.1
Natural variantiVAR_06373690G → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356670EnsemblClinVar.1
Natural variantiVAR_06373796C → S in PNDM. 1 PublicationCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_06373896C → Y in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_063739101S → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908276EnsemblClinVar.1
Natural variantiVAR_063740103Y → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908277EnsemblClinVar.1
Natural variantiVAR_063741108Y → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356672EnsemblClinVar.1
Maturity-onset diabetes of the young 10 (MODY10)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
See also OMIM:613370
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637216R → C in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908278EnsemblClinVar.1
Natural variantiVAR_0637226R → H in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908259EnsemblClinVar.1
Natural variantiVAR_06372946R → Q in MODY10; reduces binding affinity to INSR; reduces biological activity; reduces folding properties. 3 PublicationsCorresponds to variant dbSNP:rs121908260EnsemblClinVar.1

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
3630

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
INS

MalaCards human disease database

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MalaCardsi
INS
MIMi125852 phenotype
606176 phenotype
613370 phenotype
616214 phenotype

Open Targets

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OpenTargetsi
ENSG00000254647

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
552 MODY
99885 Permanent neonatal diabetes mellitus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA201

Protein family/group databases

Allergome; a platform for allergen knowledge

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Allergomei
2121 Hom s Insulin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5881

Drug and drug target database

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DrugBanki
DB01776 M-Cresol
DB08231 MYRISTIC ACID

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
INS

Domain mapping of disease mutations (DMDM)

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DMDMi
124617

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001581925 – 54Insulin B chainAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001582057 – 87C peptideAdd BLAST31
PeptideiPRO_000001582190 – 110Insulin A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 96Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi43 ↔ 109Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi95 ↔ 100Combined sources5 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P01308

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P01308

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P01308

PeptideAtlas

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PeptideAtlasi
P01308

PRoteomics IDEntifications database

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PRIDEi
P01308

ProteomicsDB human proteome resource

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ProteomicsDBi
51374

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P01308

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P01308

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P01308

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P01308

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P01308 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P01308 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB000048
CAB012098
CAB053843
HPA004932

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds (PubMed:25423173).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109842, 13 interactors

Database of interacting proteins

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DIPi
DIP-6024N

Protein interaction database and analysis system

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IntActi
P01308, 16 interactors

Molecular INTeraction database

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MINTi
P01308

STRING: functional protein association networks

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STRINGi
9606.ENSP00000380432

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7FNMR-A90-110[»]
B25-53[»]
1AI0NMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1B9EX-ray2.50A/C90-110[»]
B/D25-54[»]
1BENX-ray1.40A/C90-110[»]
B/D25-54[»]
1EFENMR-A25-54[»]
A90-110[»]
1EV3X-ray1.78A/C90-110[»]
B/D25-54[»]
1EV6X-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1EVRX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1FU2X-ray3.24A/C/E/G90-110[»]
B/D/F/H25-54[»]
1FUBX-ray3.09A/C90-110[»]
B/D25-54[»]
1G7AX-ray1.20A/C/E/G90-110[»]
B/D/F/H25-54[»]
1G7BX-ray1.30A/C/E/G90-110[»]
B/D/F/H25-54[»]
1GUJX-ray1.62A/C90-110[»]
B/D25-54[»]
1HIQNMR-A90-110[»]
B25-54[»]
1HISNMR-A90-110[»]
B25-49[»]
1HITNMR-A90-110[»]
B25-54[»]
1HLSNMR-A90-110[»]
B25-54[»]
1HTVX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-51[»]
1HUINMR-A90-110[»]
B26-53[»]
1IOGNMR-A90-110[»]
B25-53[»]
1IOHNMR-A90-110[»]
B25-53[»]
1J73X-ray2.00A/C90-110[»]
B/D25-54[»]
1JCAX-ray2.50A/C90-110[»]
B/D25-54[»]
1JCONMR-A90-110[»]
B25-54[»]
1JK8X-ray2.40C35-47[»]
1K3MNMR-A90-110[»]
B25-54[»]
1KMFNMR-A90-110[»]
B25-54[»]
1LKQNMR-A90-110[»]
B25-54[»]
1LPHX-ray2.30A/C90-110[»]
B/D25-54[»]
1MHINMR-A90-110[»]
B25-54[»]
1MHJNMR-A90-110[»]
B25-54[»]
1MSOX-ray1.00A/C90-110[»]
B/D25-54[»]
1OS3X-ray1.95A/C90-110[»]
B/D25-54[»]
1OS4X-ray2.25A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1Q4VX-ray2.00A/C90-110[»]
B/D25-54[»]
1QIYX-ray2.30A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1QIZX-ray2.00A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1QJ0X-ray2.40A/C90-110[»]
B/D25-54[»]
1RWEX-ray1.80A/C90-110[»]
B/D25-54[»]
1SF1NMR-A90-110[»]
B25-54[»]
1SJTNMR-A90-110[»]
B25-51[»]
1SJUNMR-A25-110[»]
1T0CNMR-A57-87[»]
1T1KNMR-A90-110[»]
B25-54[»]
1T1PNMR-A90-110[»]
B25-54[»]
1T1QNMR-A90-110[»]
B25-54[»]
1TRZX-ray1.60A/C90-110[»]
B/D25-54[»]
1TYLX-ray1.90A/C90-110[»]
B/D25-54[»]
1TYMX-ray1.90A/C90-110[»]
B/D25-54[»]
1UZ9X-ray1.60A90-110[»]
B25-53[»]
1VKTNMR-A90-110[»]
B25-54[»]
1W8PX-ray2.08A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1XDAX-ray1.80A/C/E/G90-110[»]
B/D/F/H25-53[»]
1XGLNMR-A90-110[»]
B25-54[»]
1XW7X-ray2.30A/C90-110[»]
B/D25-54[»]
1ZEGX-ray1.60A/C90-110[»]
B/D25-54[»]
1ZEHX-ray1.50A/C90-110[»]
B/D25-54[»]
1ZNJX-ray2.00A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2C8QX-ray1.95A90-110[»]
B25-53[»]
2C8RX-ray1.50A90-110[»]
B25-53[»]
2CEUX-ray1.80A/C90-110[»]
B/D25-49[»]
2G54X-ray2.25C/D25-54[»]
2G56X-ray2.20C/D25-54[»]
2H67NMR-A90-110[»]
B25-54[»]
2HH4NMR-A90-110[»]
B25-54[»]
2HHONMR-A90-110[»]
B25-54[»]
2HIUNMR-A90-110[»]
B25-54[»]
2JMNNMR-A90-110[»]
B25-54[»]
2JUMNMR-A90-110[»]
B25-54[»]
2JUUNMR-A90-110[»]
B25-54[»]
2JUVNMR-A90-110[»]
B25-54[»]
2JV1NMR-A90-110[»]
B25-54[»]
2JZQNMR-A25-54[»]
A90-110[»]
2K91NMR-A90-110[»]
B25-54[»]
2K9RNMR-A90-110[»]
B25-54[»]
2KJJNMR-A90-110[»]
B25-54[»]
2KJUNMR-A90-110[»]
B25-54[»]
2KQPNMR-A25-110[»]
2KQQNMR-A90-110[»]
B25-54[»]
2KXKNMR-A90-110[»]
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6B3Qelectron microscopy3.70a/b1-110[»]
6B70electron microscopy3.70a/c1-110[»]
6BFCelectron microscopy3.70a/b1-110[»]
6CE7electron microscopy7.40N90-110[»]
6CE9electron microscopy4.30K/N90-110[»]
6CEBelectron microscopy4.70K/N90-110[»]
6CK2X-ray2.25A/C90-110[»]
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6HN5electron microscopy3.20A90-110[»]
B25-54[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01308

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01308

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0XC Eukaryota
ENOG4111VJB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015440

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000261669

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01308

KEGG Orthology (KO)

More...
KOi
K04526

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFFYSPK

Database of Orthologous Groups

More...
OrthoDBi
1438615at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01308

TreeFam database of animal gene trees

More...
TreeFami
TF332820

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00049 Insulin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00277 INSULIN
PR00276 INSULINFAMLY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00078 IlGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56994 SSF56994, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00262 INSULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P01308-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC
110
SLYQLENYCN
Length:110
Mass (Da):11,981
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2C3B23B85E520E5
GO
Isoform 2 (identifier: F8WCM5-1) [UniParc]FASTAAdd to basket
Also known as: INS-IGF2
The sequence of this isoform can be found in the external entry F8WCM5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a readthrough transcript which may produce an INS-IGF2 fusion protein.
Length:200
Mass (Da):21,537
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6XGL2A6XGL2_HUMAN
Insulin
INS
98Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNR5C9JNR5_HUMAN
Insulin
INS
92Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA59179 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637216R → C in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908278EnsemblClinVar.1
Natural variantiVAR_0637226R → H in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908259EnsemblClinVar.1
Natural variantiVAR_06372324A → D in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356663EnsemblClinVar.1
Natural variantiVAR_06372429H → D in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908272EnsemblClinVar.1
Natural variantiVAR_06372532G → R in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372632G → S in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_00397134H → D in HPRI; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918101EnsemblClinVar.1
Natural variantiVAR_06372735L → P in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908273EnsemblClinVar.1
Natural variantiVAR_06372843C → G in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356666EnsemblClinVar.1
Natural variantiVAR_06372946R → Q in MODY10; reduces binding affinity to INSR; reduces biological activity; reduces folding properties. 3 PublicationsCorresponds to variant dbSNP:rs121908260EnsemblClinVar.1
Natural variantiVAR_06373047G → V in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356667EnsemblClinVar.1
Natural variantiVAR_06373148F → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_00397248F → S Associated with diabetes mellitus type-II; Los-Angeles. 3 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_00397349F → L in Chicago. 1 PublicationCorresponds to variant dbSNP:rs148685531EnsemblClinVar.1
Natural variantiVAR_06373255R → C in IDDM2. 1 PublicationCorresponds to variant dbSNP:rs121908261EnsemblClinVar.1
Natural variantiVAR_06373368L → M1 PublicationCorresponds to variant dbSNP:rs121908279EnsemblClinVar.1
Natural variantiVAR_06373484G → R in PNDM; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121908274EnsemblClinVar.1
Natural variantiVAR_06373589R → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356669EnsemblClinVar.1
Natural variantiVAR_00397489R → H in HPRI; impairs post-translational cleavage. 2 PublicationsCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_00397589R → L in HPRI; Kyoto. 1 PublicationCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_06373690G → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356670EnsemblClinVar.1
Natural variantiVAR_00397692V → L in Wakayama. 1 PublicationCorresponds to variant dbSNP:rs121918102EnsemblClinVar.1
Natural variantiVAR_06373796C → S in PNDM. 1 PublicationCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_06373896C → Y in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_063739101S → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908276EnsemblClinVar.1
Natural variantiVAR_063740103Y → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908277EnsemblClinVar.1
Natural variantiVAR_063741108Y → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356672EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00565 Genomic DNA Translation: CAA23828.1
M10039 Genomic DNA Translation: AAA59173.1
J00265 Genomic DNA Translation: AAA59172.1
X70508 mRNA Translation: CAA49913.1
L15440 Genomic DNA Translation: AAA59179.1 Sequence problems.
AY899304 mRNA Translation: AAW83741.1
AY138590 Genomic DNA Translation: AAN39451.1
BT006808 mRNA Translation: AAP35454.1
CH471158 Genomic DNA Translation: EAX02488.1
BC005255 mRNA Translation: AAH05255.1
AJ009655 Genomic DNA Translation: CAA08766.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7729.1 [P01308-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A93222 IPHU

NCBI Reference Sequences

More...
RefSeqi
NP_000198.1, NM_000207.2 [P01308-1]
NP_001172026.1, NM_001185097.1 [P01308-1]
NP_001172027.1, NM_001185098.1 [P01308-1]
NP_001278826.1, NM_001291897.1 [P01308-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000250971; ENSP00000250971; ENSG00000254647 [P01308-1]
ENST00000381330; ENSP00000370731; ENSG00000254647 [P01308-1]
ENST00000397262; ENSP00000380432; ENSG00000254647 [P01308-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3630

UCSC genome browser

More...
UCSCi
uc001lvn.3 human [P01308-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Insulin at Eli Lilly

Clinical information on Eli Lilly insulin products

Protein Spotlight

Protein of the 20th century - Issue 9 of April 2001

Wikipedia

Insulin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00565 Genomic DNA Translation: CAA23828.1
M10039 Genomic DNA Translation: AAA59173.1
J00265 Genomic DNA Translation: AAA59172.1
X70508 mRNA Translation: CAA49913.1
L15440 Genomic DNA Translation: AAA59179.1 Sequence problems.
AY899304 mRNA Translation: AAW83741.1
AY138590 Genomic DNA Translation: AAN39451.1
BT006808 mRNA Translation: AAP35454.1
CH471158 Genomic DNA Translation: EAX02488.1
BC005255 mRNA Translation: AAH05255.1
AJ009655 Genomic DNA Translation: CAA08766.1
CCDSiCCDS7729.1 [P01308-1]
PIRiA93222 IPHU
RefSeqiNP_000198.1, NM_000207.2 [P01308-1]
NP_001172026.1, NM_001185097.1 [P01308-1]
NP_001172027.1, NM_001185098.1 [P01308-1]
NP_001278826.1, NM_001291897.1 [P01308-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7FNMR-A90-110[»]
B25-53[»]
1AI0NMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1B9EX-ray2.50A/C90-110[»]
B/D25-54[»]
1BENX-ray1.40A/C90-110[»]
B/D25-54[»]
1EFENMR-A25-54[»]
A90-110[»]
1EV3X-ray1.78A/C90-110[»]
B/D25-54[»]
1EV6X-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1EVRX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1FU2X-ray3.24A/C/E/G90-110[»]
B/D/F/H25-54[»]
1FUBX-ray3.09A/C90-110[»]
B/D25-54[»]
1G7AX-ray1.20A/C/E/G90-110[»]
B/D/F/H25-54[»]
1G7BX-ray1.30A/C/E/G90-110[»]
B/D/F/H25-54[»]
1GUJX-ray1.62A/C90-110[»]
B/D25-54[»]
1HIQNMR-A90-110[»]
B25-54[»]
1HISNMR-A90-110[»]
B25-49[»]
1HITNMR-A90-110[»]
B25-54[»]
1HLSNMR-A90-110[»]
B25-54[»]
1HTVX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-51[»]
1HUINMR-A90-110[»]
B26-53[»]
1IOGNMR-A90-110[»]
B25-53[»]
1IOHNMR-A90-110[»]
B25-53[»]
1J73X-ray2.00A/C90-110[»]
B/D25-54[»]
1JCAX-ray2.50A/C90-110[»]
B/D25-54[»]
1JCONMR-A90-110[»]
B25-54[»]
1JK8X-ray2.40C35-47[»]
1K3MNMR-A90-110[»]
B25-54[»]
1KMFNMR-A90-110[»]
B25-54[»]
1LKQNMR-A90-110[»]
B25-54[»]
1LPHX-ray2.30A/C90-110[»]
B/D25-54[»]
1MHINMR-A90-110[»]
B25-54[»]
1MHJNMR-A90-110[»]
B25-54[»]
1MSOX-ray1.00A/C90-110[»]
B/D25-54[»]
1OS3X-ray1.95A/C90-110[»]
B/D25-54[»]
1OS4X-ray2.25A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1Q4VX-ray2.00A/C90-110[»]
B/D25-54[»]
1QIYX-ray2.30A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1QIZX-ray2.00A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1QJ0X-ray2.40A/C90-110[»]
B/D25-54[»]
1RWEX-ray1.80A/C90-110[»]
B/D25-54[»]
1SF1NMR-A90-110[»]
B25-54[»]
1SJTNMR-A90-110[»]
B25-51[»]
1SJUNMR-A25-110[»]
1T0CNMR-A57-87[»]
1T1KNMR-A90-110[»]
B25-54[»]
1T1PNMR-A90-110[»]
B25-54[»]
1T1QNMR-A90-110[»]
B25-54[»]
1TRZX-ray1.60A/C90-110[»]
B/D25-54[»]
1TYLX-ray1.90A/C90-110[»]
B/D25-54[»]
1TYMX-ray1.90A/C90-110[»]
B/D25-54[»]
1UZ9X-ray1.60A90-110[»]
B25-53[»]
1VKTNMR-A90-110[»]
B25-54[»]
1W8PX-ray2.08A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1XDAX-ray1.80A/C/E/G90-110[»]
B/D/F/H25-53[»]
1XGLNMR-A90-110[»]
B25-54[»]
1XW7X-ray2.30A/C90-110[»]
B/D25-54[»]
1ZEGX-ray1.60A/C90-110[»]
B/D25-54[»]
1ZEHX-ray1.50A/C90-110[»]
B/D25-54[»]
1ZNJX-ray2.00A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2C8QX-ray1.95A90-110[»]
B25-53[»]
2C8RX-ray1.50A90-110[»]
B25-53[»]
2CEUX-ray1.80A/C90-110[»]
B/D25-49[»]
2G54X-ray2.25C/D25-54[»]
2G56X-ray2.20C/D25-54[»]
2H67NMR-A90-110[»]
B25-54[»]
2HH4NMR-A90-110[»]
B25-54[»]
2HHONMR-A90-110[»]
B25-54[»]
2HIUNMR-A90-110[»]
B25-54[»]
2JMNNMR-A90-110[»]
B25-54[»]
2JUMNMR-A90-110[»]
B25-54[»]
2JUUNMR-A90-110[»]
B25-54[»]
2JUVNMR-A90-110[»]
B25-54[»]
2JV1NMR-A90-110[»]
B25-54[»]
2JZQNMR-A25-54[»]
A90-110[»]
2K91NMR-A90-110[»]
B25-54[»]
2K9RNMR-A90-110[»]
B25-54[»]
2KJJNMR-A90-110[»]
B25-54[»]
2KJUNMR-A90-110[»]
B25-54[»]
2KQPNMR-A25-110[»]
2KQQNMR-A90-110[»]
B25-54[»]
2KXKNMR-A90-110[»]
B25-54[»]
2L1YNMR-A90-110[»]
B25-54[»]
2L1ZNMR-A90-110[»]
B25-54[»]
2LGBNMR-A90-110[»]
B25-55[»]
2LWZNMR-A25-54[»]
A89-110[»]
2M1DNMR-A90-110[»]
B25-54[»]
2M1ENMR-A90-110[»]
B25-54[»]
2M2MNMR-A90-110[»]
B25-54[»]
2M2NNMR-A90-110[»]
B25-54[»]
2M2ONMR-A90-110[»]
B25-54[»]
2M2PNMR-A90-110[»]
B25-54[»]
2MLINMR-A90-110[»]
B25-54[»]
2MPGNMR-A90-110[»]
B25-54[»]
2MPINMR-A90-110[»]
B25-54[»]
2MVCNMR-A90-110[»]
B25-54[»]
2MVDNMR-A90-110[»]
B25-54[»]
2N2VNMR-A90-110[»]
B25-54[»]
2N2WNMR-A90-110[»]
B25-54[»]
2N2XNMR-A90-110[»]
B25-54[»]
2OLYX-ray1.70A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OLZX-ray1.70A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OM0X-ray2.051/3/A/C/E/G/I/K/Q/S/U/X/a/c/e/g/i/k90-110[»]
2/4/B/D/F/H/J/L/R/T/V/Y/b/d/f/h/j/l25-54[»]
2OM1X-ray1.971/3/A/C/E/G/I/K/Q/S/U/X/a/c/e/g/i/k90-110[»]
2/4/B/D/F/H/J/L/R/T/V/Y/b/d/f/h/j/l25-54[»]
2OMGX-ray1.52A/C/E90-110[»]
B/D/F25-54[»]
2OMHX-ray1.36A/C/E90-110[»]
B/D/F25-54[»]
2OMIX-ray2.24A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OMQX-ray2.00A/B/C/D36-41[»]
2QIUX-ray2.00A/C89-110[»]
B/D25-54[»]
2R34X-ray2.25A/C89-110[»]
B/D25-54[»]
2R35X-ray2.08A/C