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UniProtKB - P01308 (INS_HUMAN)

Protein

Insulin

Gene

INS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • identical protein binding Source: IntAct
  • insulin-like growth factor receptor binding Source: BHF-UCL
  • insulin receptor binding Source: UniProtKB
  • protease binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16190
ReactomeiR-HSA-210745 Regulation of gene expression in beta cells
R-HSA-264876 Insulin processing
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
R-HSA-422356 Regulation of insulin secretion
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-77387 Insulin receptor recycling
R-HSA-977225 Amyloid fiber formation
SignaLinkiP01308
SIGNORiP01308

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
Insulin B chain
Insulin A chain
Gene namesi
Name:INS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000254647.6
HGNCiHGNC:6081 INS
MIMi176730 gene
neXtProtiNX_P01308

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hyperproinsulinemia (HPRI)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant condition characterized by elevated levels of serum proinsulin-like material.
See also OMIM:616214
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00397134H → D in HPRI; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918101EnsemblClinVar.1
Natural variantiVAR_00397489R → H in HPRI; impairs post-translational cleavage. 2 PublicationsCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_00397589R → L in HPRI; Kyoto. 1 PublicationCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Diabetes mellitus, insulin-dependent, 2 (IDDM2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:125852
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06373255R → C in IDDM2. 1 PublicationCorresponds to variant dbSNP:rs121908261EnsemblClinVar.1
Diabetes mellitus, permanent neonatal (PNDM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
See also OMIM:606176
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06372324A → D in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356663EnsemblClinVar.1
Natural variantiVAR_06372429H → D in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908272EnsemblClinVar.1
Natural variantiVAR_06372532G → R in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372632G → S in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372735L → P in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908273EnsemblClinVar.1
Natural variantiVAR_06372843C → G in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356666EnsemblClinVar.1
Natural variantiVAR_06373047G → V in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356667EnsemblClinVar.1
Natural variantiVAR_06373148F → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_06373484G → R in PNDM; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121908274EnsemblClinVar.1
Natural variantiVAR_06373589R → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356669EnsemblClinVar.1
Natural variantiVAR_06373690G → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356670EnsemblClinVar.1
Natural variantiVAR_06373796C → S in PNDM. 1 PublicationCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_06373896C → Y in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_063739101S → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908276EnsemblClinVar.1
Natural variantiVAR_063740103Y → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908277EnsemblClinVar.1
Natural variantiVAR_063741108Y → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356672EnsemblClinVar.1
Maturity-onset diabetes of the young 10 (MODY10)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
See also OMIM:613370
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637216R → C in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908278EnsemblClinVar.1
Natural variantiVAR_0637226R → H in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908259EnsemblClinVar.1
Natural variantiVAR_06372946R → Q in MODY10; reduces binding affinity to INSR; reduces biological activity; reduces folding properties. 3 PublicationsCorresponds to variant dbSNP:rs121908260EnsemblClinVar.1

Pharmaceutical usei

Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNETi3630
GeneReviewsiINS
MalaCardsiINS
MIMi125852 phenotype
606176 phenotype
613370 phenotype
616214 phenotype
OpenTargetsiENSG00000254647
Orphaneti552 MODY
99885 Permanent neonatal diabetes mellitus
PharmGKBiPA201

Protein family/group databases

Allergomei2121 Hom s Insulin

Chemistry databases

ChEMBLiCHEMBL5881
DrugBankiDB01776 M-Cresol
DB08231 MYRISTIC ACID

Polymorphism and mutation databases

BioMutaiINS
DMDMi124617

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001581925 – 54Insulin B chainAdd BLAST30
PropeptideiPRO_000001582057 – 87C peptideAdd BLAST31
PeptideiPRO_000001582190 – 110Insulin A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 96Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi43 ↔ 109Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi95 ↔ 100Combined sources5 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

EPDiP01308
PaxDbiP01308
PeptideAtlasiP01308
PRIDEiP01308
ProteomicsDBi51374

PTM databases

CarbonylDBiP01308
iPTMnetiP01308
PhosphoSitePlusiP01308

Miscellaneous databases

PMAP-CutDBiP01308

Expressioni

Gene expression databases

BgeeiENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell
ExpressionAtlasiP01308 baseline and differential
GenevisibleiP01308 HS

Organism-specific databases

HPAiCAB000048
CAB012098
CAB053843
HPA004932

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds (PubMed:25423173).1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi109842, 13 interactors
DIPiDIP-6024N
IntActiP01308, 14 interactors
MINTiP01308
STRINGi9606.ENSP00000250971

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01308
SMRiP01308
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01308

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiP01308
KOiK04526
OMAiPQHLCGS
OrthoDBiEOG091G0H56
PhylomeDBiP01308
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P01308-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY 
        60         70         80         90        100
TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC 
       110
SLYQLENYCN
Length:110
Mass (Da):11,981
Last modified:July 21, 1986 - v1
Checksum:iC2C3B23B85E520E5
GO
Isoform 2 (identifier: F8WCM5-1) [UniParc]FASTAAdd to basket
Also known as: INS-IGF2
The sequence of this isoform can be found in the external entry F8WCM5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a readthrough transcript which may produce an INS-IGF2 fusion protein.
Length:200
Mass (Da):21,537
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6XGL2A6XGL2_HUMAN
Insulin
INS
98Annotation score:
C9JNR5C9JNR5_HUMAN
Insulin
INS
92Annotation score:

Sequence cautioni

The sequence AAA59179 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637216R → C in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908278EnsemblClinVar.1
Natural variantiVAR_0637226R → H in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908259EnsemblClinVar.1
Natural variantiVAR_06372324A → D in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356663EnsemblClinVar.1
Natural variantiVAR_06372429H → D in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908272EnsemblClinVar.1
Natural variantiVAR_06372532G → R in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372632G → S in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_00397134H → D in HPRI; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918101EnsemblClinVar.1
Natural variantiVAR_06372735L → P in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908273EnsemblClinVar.1
Natural variantiVAR_06372843C → G in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356666EnsemblClinVar.1
Natural variantiVAR_06372946R → Q in MODY10; reduces binding affinity to INSR; reduces biological activity; reduces folding properties. 3 PublicationsCorresponds to variant dbSNP:rs121908260EnsemblClinVar.1
Natural variantiVAR_06373047G → V in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356667EnsemblClinVar.1
Natural variantiVAR_06373148F → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_00397248F → S Associated with diabetes mellitus type-II; Los-Angeles. 3 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_00397349F → L in Chicago. 1 PublicationCorresponds to variant dbSNP:rs148685531EnsemblClinVar.1
Natural variantiVAR_06373255R → C in IDDM2. 1 PublicationCorresponds to variant dbSNP:rs121908261EnsemblClinVar.1
Natural variantiVAR_06373368L → M1 PublicationCorresponds to variant dbSNP:rs121908279EnsemblClinVar.1
Natural variantiVAR_06373484G → R in PNDM; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121908274EnsemblClinVar.1
Natural variantiVAR_06373589R → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356669EnsemblClinVar.1
Natural variantiVAR_00397489R → H in HPRI; impairs post-translational cleavage. 2 PublicationsCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_00397589R → L in HPRI; Kyoto. 1 PublicationCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_06373690G → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356670EnsemblClinVar.1
Natural variantiVAR_00397692V → L in Wakayama. 1 PublicationCorresponds to variant dbSNP:rs121918102EnsemblClinVar.1
Natural variantiVAR_06373796C → S in PNDM. 1 PublicationCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_06373896C → Y in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_063739101S → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908276EnsemblClinVar.1
Natural variantiVAR_063740103Y → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908277EnsemblClinVar.1
Natural variantiVAR_063741108Y → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356672EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00565 Genomic DNA Translation: CAA23828.1
M10039 Genomic DNA Translation: AAA59173.1
J00265 Genomic DNA Translation: AAA59172.1
X70508 mRNA Translation: CAA49913.1
L15440 Genomic DNA Translation: AAA59179.1 Sequence problems.
AY899304 mRNA Translation: AAW83741.1
AY138590 Genomic DNA Translation: AAN39451.1
BT006808 mRNA Translation: AAP35454.1
CH471158 Genomic DNA Translation: EAX02488.1
BC005255 mRNA Translation: AAH05255.1
AJ009655 Genomic DNA Translation: CAA08766.1
CCDSiCCDS7729.1 [P01308-1]
PIRiA93222 IPHU
RefSeqiNP_000198.1, NM_000207.2 [P01308-1]
NP_001172026.1, NM_001185097.1 [P01308-1]
NP_001172027.1, NM_001185098.1 [P01308-1]
NP_001278826.1, NM_001291897.1 [P01308-1]
UniGeneiHs.272259

Genome annotation databases

EnsembliENST00000250971; ENSP00000250971; ENSG00000254647 [P01308-1]
ENST00000381330; ENSP00000370731; ENSG00000254647 [P01308-1]
ENST00000397262; ENSP00000380432; ENSG00000254647 [P01308-1]
GeneIDi3630
KEGGihsa:3630
UCSCiuc001lvn.3 human [P01308-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Insulin at Eli Lilly

Clinical information on Eli Lilly insulin products

Protein Spotlight

Protein of the 20th century - Issue 9 of April 2001

Wikipedia

Insulin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00565 Genomic DNA Translation: CAA23828.1
M10039 Genomic DNA Translation: AAA59173.1
J00265 Genomic DNA Translation: AAA59172.1
X70508 mRNA Translation: CAA49913.1
L15440 Genomic DNA Translation: AAA59179.1 Sequence problems.
AY899304 mRNA Translation: AAW83741.1
AY138590 Genomic DNA Translation: AAN39451.1
BT006808 mRNA Translation: AAP35454.1
CH471158 Genomic DNA Translation: EAX02488.1
BC005255 mRNA Translation: AAH05255.1
AJ009655 Genomic DNA Translation: CAA08766.1
CCDSiCCDS7729.1 [P01308-1]
PIRiA93222 IPHU
RefSeqiNP_000198.1, NM_000207.2 [P01308-1]
NP_001172026.1, NM_001185097.1 [P01308-1]
NP_001172027.1, NM_001185098.1 [P01308-1]
NP_001278826.1, NM_001291897.1 [P01308-1]
UniGeneiHs.272259

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7FNMR-A90-110[»]
B25-53[»]
1AI0NMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1B9EX-ray2.50A/C90-110[»]
B/D25-54[»]
1BENX-ray1.40A/C90-110[»]
B/D25-54[»]
1EFENMR-A25-54[»]
A90-110[»]
1EV3X-ray1.78A/C90-110[»]
B/D25-54[»]
1EV6X-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1EVRX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1FU2X-ray3.24A/C/E/G90-110[»]
B/D/F/H25-54[»]
1FUBX-ray3.09A/C90-110[»]
B/D25-54[»]
1G7AX-ray1.20A/C/E/G90-110[»]
B/D/F/H25-54[»]
1G7BX-ray1.30A/C/E/G90-110[»]
B/D/F/H25-54[»]
1GUJX-ray1.62A/C90-110[»]
B/D25-54[»]
1HIQNMR-A90-110[»]
B25-54[»]
1HISNMR-A90-110[»]
B25-49[»]
1HITNMR-A90-110[»]
B25-54[»]
1HLSNMR-A90-110[»]
B25-54[»]
1HTVX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-51[»]
1HUINMR-A90-110[»]
B26-53[»]
1IOGNMR-A90-110[»]
B25-53[»]
1IOHNMR-A90-110[»]
B25-53[»]
1J73X-ray2.00A/C90-110[»]
B/D25-54[»]
1JCAX-ray2.50A/C90-110[»]
B/D25-54[»]
1JCONMR-A90-110[»]
B25-54[»]
1JK8X-ray2.40C35-47[»]
1K3MNMR-A90-110[»]
B25-54[»]
1KMFNMR-A90-110[»]
B25-54[»]
1LKQNMR-A90-110[»]
B25-54[»]
1LPHX-ray2.30A/C90-110[»]
B/D25-54[»]
1MHINMR-A90-110[»]
B25-54[»]
1MHJNMR-A90-110[»]
B25-54[»]
1MSOX-ray1.00A/C90-110[»]
B/D25-54[»]
1OS3X-ray1.95A/C90-110[»]
B/D25-54[»]
1OS4X-ray2.25A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1Q4VX-ray2.00A/C90-110[»]
B/D25-54[»]
1QIYX-ray2.30A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1QIZX-ray2.00A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1QJ0X-ray2.40A/C90-110[»]
B/D25-54[»]
1RWEX-ray1.80A/C90-110[»]
B/D25-54[»]
1SF1NMR-A90-110[»]
B25-54[»]
1SJTNMR-A90-110[»]
B25-51[»]
1SJUNMR-A25-110[»]
1T0CNMR-A57-87[»]
1T1KNMR-A90-110[»]
B25-54[»]
1T1PNMR-A90-110[»]
B25-54[»]
1T1QNMR-A90-110[»]
B25-54[»]
1TRZX-ray1.60A/C90-110[»]
B/D25-54[»]
1TYLX-ray1.90A/C90-110[»]
B/D25-54[»]
1TYMX-ray1.90A/C90-110[»]
B/D25-54[»]
1UZ9X-ray1.60A90-110[»]
B25-53[»]
1VKTNMR-A90-110[»]
B25-54[»]
1W8PX-ray2.08A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1XDAX-ray1.80A/C/E/G90-110[»]
B/D/F/H25-53[»]
1XGLNMR-A90-110[»]
B25-54[»]
1XW7X-ray2.30A/C90-110[»]
B/D25-54[»]
1ZEGX-ray1.60A/C90-110[»]
B/D25-54[»]
1ZEHX-ray1.50A/C90-110[»]
B/D25-54[»]
1ZNJX-ray2.00A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2C8QX-ray1.95A90-110[»]
B25-53[»]
2C8RX-ray1.50A90-110[»]
B25-53[»]
2CEUX-ray1.80A/C90-110[»]
B/D25-49[»]
2G54X-ray2.25C/D25-54[»]
2G56X-ray2.20C/D25-54[»]
2H67NMR-A90-110[»]
B25-54[»]
2HH4NMR-A90-110[»]
B25-54[»]
2HHONMR-A90-110[»]
B25-54[»]
2HIUNMR-A90-110[»]
B25-54[»]
2JMNNMR-A90-110[»]
B25-54[»]
2JUMNMR-A90-110[»]
B25-54[»]
2JUUNMR-A90-110[»]
B25-54[»]
2JUVNMR-A90-110[»]
B25-54[»]
2JV1NMR-A90-110[»]
B25-54[»]
2JZQNMR-A25-54[»]
A90-110[»]
2K91NMR-A90-110[»]
B25-54[»]
2K9RNMR-A90-110[»]
B25-54[»]
2KJJNMR-A90-110[»]
B25-54[»]
2KJUNMR-A90-110[»]
B25-54[»]
2KQPNMR-A25-110[»]
2KQQNMR-A90-110[»]
B25-54[»]
2KXKNMR-A90-110[»]
B25-54[»]
2L1YNMR-A90-110[»]
B25-54[»]
2L1ZNMR-A90-110[»]
B25-54[»]
2LGBNMR-A90-110[»]
B25-55[»]
2LWZNMR-A25-54[»]
A89-110[»]
2M1DNMR-A90-110[»]
B25-54[»]
2M1ENMR-A90-110[»]
B25-54[»]
2M2MNMR-A90-110[»]
B25-54[»]
2M2NNMR-A90-110[»]
B25-54[»]
2M2ONMR-A90-110[»]
B25-54[»]
2M2PNMR-A90-110[»]
B25-54[»]
2MLINMR-A90-110[»]
B25-54[»]
2MPGNMR-A90-110[»]
B25-54[»]
2MPINMR-A90-110[»]
B25-54[»]
2MVCNMR-A90-110[»]
B25-54[»]
2MVDNMR-A90-110[»]
B25-54[»]
2N2VNMR-A90-110[»]
B25-54[»]
2N2WNMR-A90-110[»]
B25-54[»]
2N2XNMR-A90-110[»]
B25-54[»]
2OLYX-ray1.70A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OLZX-ray1.70A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OM0X-ray2.051/3/A/C/E/G/I/K/Q/S/U/X/a/c/e/g/i/k90-110[»]
2/4/B/D/F/H/J/L/R/T/V/Y/b/d/f/h/j/l25-54[»]
2OM1X-ray1.971/3/A/C/E/G/I/K/Q/S/U/X/a/c/e/g/i/k90-110[»]
2/4/B/D/F/H/J/L/R/T/V/Y/b/d/f/h/j/l25-54[»]
2OMGX-ray1.52A/C/E90-110[»]
B/D/F25-54[»]
2OMHX-ray1.36A/C/E90-110[»]
B/D/F25-54[»]
2OMIX-ray2.24A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OMQX-ray2.00A/B/C/D36-41[»]
2QIUX-ray2.00A/C89-110[»]
B/D25-54[»]
2R34X-ray2.25A/C89-110[»]
B/D25-54[»]
2R35X-ray2.08A/C89-110[»]
B/D25-54[»]
2R36X-ray2.00A/C89-110[»]
B/D25-54[»]
2RN5NMR-A90-110[»]
B25-54[»]
2VJZX-ray1.80A/C90-110[»]
B/D25-54[»]
2VK0X-ray2.20A/C90-110[»]
B/D25-54[»]
2W44X-ray2.00A/C/E94-110[»]
B/D/F25-53[»]
2WBYX-ray2.60C/E90-109[»]
D/F25-43[»]
2WC0X-ray2.80C/E90-110[»]
D/F25-54[»]
2WRUX-ray1.57A90-110[»]
B25-50[»]
2WRVX-ray2.15A90-110[»]
B25-50[»]
2WRWX-ray2.41A90-110[»]
B25-50[»]
2WRXX-ray1.50A/C90-110[»]
B/D25-54[»]
2WS0X-ray2.10A90-110[»]
B25-54[»]
2WS1X-ray1.60A90-110[»]
B25-54[»]
2WS4X-ray1.90A90-110[»]
B25-50[»]
2WS6X-ray1.50A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2WS7X-ray2.59A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-50[»]
3AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
3BXQX-ray1.30A/C90-110[»]
B/D25-54[»]
3E7YX-ray1.60A/C90-110[»]
B/D25-53[»]
3E7ZX-ray1.70A/C90-110[»]
B/D25-53[»]
3EXXX-ray1.35A/C90-110[»]
B/D25-54[»]
3FQ9X-ray1.35A/C91-110[»]
B/D25-54[»]
3HYDX-ray1.00A35-41[»]
3I3ZX-ray1.60A90-110[»]
B25-54[»]
3I40X-ray1.85A90-110[»]
B25-54[»]
3ILGX-ray1.90A/C90-110[»]
B/D25-54[»]
3INCX-ray1.85A/C90-110[»]
B/D25-54[»]
3IR0X-ray2.20A/C/E/G/I/K/M/O/R/T/V/X90-110[»]
B/D/F/H/J/L/N/P/S/U/W/Y25-54[»]
3JSDX-ray2.50A/C90-110[»]
B/D25-54[»]
3KQ6X-ray1.90A/C90-110[»]
B/D25-54[»]
3P2XX-ray2.00A/C90-110[»]
B/D25-54[»]
3P33X-ray2.30A/C/E/G90-110[»]
B/D/F/H25-54[»]
3Q6EX-ray2.05A/C90-110[»]
B/D25-54[»]
3ROVX-ray2.30A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
3TT8X-ray1.12A/C90-110[»]
B/D25-54[»]
3U4NX-ray1.98A90-110[»]
B25-53[»]
3UTQX-ray1.67C15-24[»]
3UTSX-ray2.71C/H15-24[»]
3UTTX-ray2.60C/H15-24[»]
3V19X-ray2.00A/C90-110[»]
B/D25-54[»]
3V1GX-ray2.20A/C90-110[»]
B/D25-54[»]
3W11X-ray3.90A90-110[»]
B25-54[»]
3W12X-ray4.30A90-110[»]
B25-50[»]
3W13X-ray4.30A90-110[»]
B25-50[»]
3W7YX-ray0.92A/C90-110[»]
B/D25-54[»]
3W7ZX-ray1.15A/C90-110[»]
B/D25-54[»]
3W80X-ray1.40A/C/E/G90-110[»]
B/D/F/H25-54[»]
3ZI3X-ray1.70A90-110[»]
B25-54[»]
3ZQRX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
3ZS2X-ray1.97A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
3ZU1X-ray1.60A/C90-110[»]
B/D25-54[»]
4AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
4AJXX-ray1.20A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-53[»]
4AJZX-ray1.80A/C90-110[»]
B/D25-53[»]
4AK0X-ray2.28A90-110[»]
B25-53[»]
4AKJX-ray2.01A/C90-110[»]
B/D25-53[»]
4CXLX-ray1.50A90-110[»]
B25-54[»]
4CXNX-ray1.70A90-110[»]
B25-54[»]
4CY7X-ray1.40A/C90-110[»]
B/D25-54[»]
4EFXX-ray1.98A/C90-110[»]
B/D25-52[»]
4EWWX-ray2.30A/C90-110[»]
B/D25-54[»]
4EWXX-ray2.20A/C90-110[»]
B/D25-54[»]
4EWZX-ray1.79A/C90-110[»]
B/D25-54[»]
4EX0X-ray1.86A/C90-110[»]
B/D25-54[»]
4EX1X-ray1.66A/C90-110[»]
B/D25-54[»]
4EXXX-ray1.55A/C90-110[»]
B/D25-54[»]
4EY1X-ray1.47A/C90-110[»]
B/D25-54[»]
4EY9X-ray1.47A/C90-110[»]
B/D25-54[»]
4EYDX-ray1.47A/C90-110[»]
B/D25-54[»]
4EYNX-ray1.53A/C90-110[»]
B/D25-54[»]
4EYPX-ray1.59A/C90-110[»]
B/D25-54[»]
4F0NX-ray1.68A/C90-110[»]
B/D25-54[»]
4F0OX-ray1.67A/C90-110[»]
B/D25-54[»]
4F1AX-ray1.80A/C90-110[»]
B/D25-54[»]
4F1BX-ray1.59A/C90-110[»]
B/D25-54[»]
4F1CX-ray1.70A/C90-110[»]
B/D25-54[»]
4F1DX-ray1.64A/C90-110[»]
B/D25-54[»]
4F1FX-ray1.68A/C90-110[»]
B/D25-54[»]
4F1GX-ray1.64A/C90-110[»]
B/D25-54[»]
4F4TX-ray1.64A/C90-110[»]
B/D25-54[»]
4F4VX-ray1.64A/C90-110[»]
B/D25-54[»]
4F51X-ray1.64A/C90-110[»]
B/D25-54[»]
4F8FX-ray1.68A/C90-110[»]
B/D25-54[»]
4FG3X-ray2.00A/C90-110[»]
B/D25-54[»]
4FKAX-ray1.08A/C90-110[»]
B/D25-54[»]
4GBCX-ray1.78A/C90-110[»]
B/D25-54[»]
4GBIX-ray2.50A/C90-110[»]
B/D25-54[»]
4GBKX-ray2.40A/C90-110[»]
B/D25-54[»]
4GBLX-ray2.50A/C90-110[»]
B/D25-54[»]
4GBNX-ray1.87A/C90-110[»]
B/D25-54[»]
4IUZX-ray1.60A90-110[»]
B25-54[»]
4IYDX-ray1.66A90-109[»]
B25-53[»]
4IYFX-ray1.80A90-109[»]
B25-53[»]
4NIBX-ray1.40A90-110[»]
B25-54[»]
4OGAX-ray3.50A90-110[»]
B25-54[»]
4P65X-ray1.50A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
4RXWX-ray1.73A/C90-110[»]
B/D25-54[»]
4UNEX-ray1.59A/C90-110[»]
B/D25-54[»]
4UNGX-ray1.81A/C90-110[»]
B/D25-54[»]
4UNHX-ray2.75A90-110[»]
B25-54[»]
4WDIX-ray2.31C/F39-47[»]
4XC4X-ray1.50A/C90-110[»]
B/D25-54[»]
4Y19X-ray2.50C75-90[»]
4Y1AX-ray4.00C75-90[»]
4Z76X-ray1.88C/F39-46[»]
4Z77X-ray1.85C/F39-47[»]
4Z78X-ray2.30C/F/I39-48[»]
5AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
5BOQX-ray1.70A/C/E/G90-110[»]
B/D/F/H25-54[»]
5BPOX-ray1.90A/C90-110[»]
B/D25-54[»]
5BQQX-ray1.54A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-50[»]
5BTSX-ray1.77A90-110[»]
B25-54[»]
5C0DX-ray1.68C15-24[»]
5CJOX-ray3.29a90-109[»]
5CNYX-ray1.70A/C90-110[»]
B/D25-54[»]
5CO2X-ray1.70A/C90-110[»]
B/D25-54[»]
5CO6X-ray1.80A/C90-110[»]
B/D25-54[»]
5CO9X-ray1.92A/C90-110[»]
B/D25-54[»]
5E7WX-ray0.95A/C90-110[»]
B/D25-54[»]
5EMSX-ray2.30A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-52[»]
5EN9X-ray1.50A90-110[»]
B25-54[»]
5ENAX-ray1.35A90-110[»]
B25-54[»]
5HPRX-ray1.33A90-110[»]
B25-54[»]
5HPUX-ray2.20A/C90-110[»]
B/D25-54[»]
5HQIX-ray0.97A90-110[»]
B25-54[»]
5HRQX-ray1.28A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
5HYJX-ray3.06C/H15-24[»]
5MAMX-ray2.200/2/4/A/C/E/G/I/K/M/O/Q/S/U/W/Y90-110[»]
1/3/5/B/D/F/H/J/L/N/P/R/T/V/X/Z25-54[»]
5MHDNMR-A90-110[»]
B25-55[»]
5MT3X-ray2.02A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e90-110[»]
B/D/F/H/J/L/N/P/R/T/V/X/Z/b/d/f25-54[»]
5MT9X-ray1.88A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e90-110[»]
B/D/F/H/J/L/N/P/R/T/V/X/Z/b/d/f25-54[»]
5MWQNMR-A90-110[»]
B25-56[»]
5T7RX-ray1.55A/C90-110[»]
B/D25-54[»]
5UDPX-ray1.35A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
5UOZX-ray1.17A90-110[»]
B25-54[»]
5UQAX-ray1.31A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
5URTX-ray1.18A90-110[»]
B25-54[»]
5URUX-ray2.41A/C/E/G90-110[»]
B/D/F/H25-54[»]
5USPX-ray1.17A90-110[»]
B25-54[»]
5USSX-ray2.06A/C90-110[»]
B/D25-54[»]
5USVX-ray1.30A90-110[»]
B25-54[»]
5UU2X-ray1.22A90-110[»]
B25-54[»]
5UU3X-ray2.25A/C/E/G/I/K/M/O/Q/S/U/W90-110[»]
B/D/F/H/J/L/N/P/R/T/V/X25-54[»]
5UU4X-ray1.97A/C90-110[»]
B/D25-54[»]
5VIZX-ray1.70A90-109[»]
B25-53[»]
5WBTNMR-A25-54[»]
A90-110[»]
5WDMX-ray2.80A/B/C/D/E/F25-110[»]
5WOBX-ray3.95a/b/c/d/e/f/g/h90-109[»]
6B3Qelectron microscopy3.70a/b1-110[»]
6B70electron microscopy3.70a/c1-110[»]
6BFCelectron microscopy3.70a/b1-110[»]
6CE7electron microscopy7.40N90-110[»]
6CE9electron microscopy4.30K/N90-110[»]
6CEBelectron microscopy4.70K/N90-110[»]
6CK2X-ray2.25A/C90-110[»]
B/D25-54[»]
ProteinModelPortaliP01308
SMRiP01308
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109842, 13 interactors
DIPiDIP-6024N
IntActiP01308, 14 interactors
MINTiP01308
STRINGi9606.ENSP00000250971

Chemistry databases

ChEMBLiCHEMBL5881
DrugBankiDB01776 M-Cresol
DB08231 MYRISTIC ACID

Protein family/group databases

Allergomei2121 Hom s Insulin

PTM databases

CarbonylDBiP01308
iPTMnetiP01308
PhosphoSitePlusiP01308

Polymorphism and mutation databases

BioMutaiINS
DMDMi124617

Proteomic databases

EPDiP01308
PaxDbiP01308
PeptideAtlasiP01308
PRIDEiP01308
ProteomicsDBi51374

Protocols and materials databases

DNASUi3630
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250971; ENSP00000250971; ENSG00000254647 [P01308-1]
ENST00000381330; ENSP00000370731; ENSG00000254647 [P01308-1]
ENST00000397262; ENSP00000380432; ENSG00000254647 [P01308-1]
GeneIDi3630
KEGGihsa:3630
UCSCiuc001lvn.3 human [P01308-1]

Organism-specific databases

CTDi3630
DisGeNETi3630
EuPathDBiHostDB:ENSG00000254647.6
GeneCardsiINS
GeneReviewsiINS
HGNCiHGNC:6081 INS
HPAiCAB000048
CAB012098
CAB053843
HPA004932
MalaCardsiINS
MIMi125852 phenotype
176730 gene
606176 phenotype
613370 phenotype
616214 phenotype
neXtProtiNX_P01308
OpenTargetsiENSG00000254647
Orphaneti552 MODY
99885 Permanent neonatal diabetes mellitus
PharmGKBiPA201
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiP01308
KOiK04526
OMAiPQHLCGS
OrthoDBiEOG091G0H56
PhylomeDBiP01308
TreeFamiTF332820

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16190
ReactomeiR-HSA-210745 Regulation of gene expression in beta cells
R-HSA-264876 Insulin processing
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
R-HSA-422356 Regulation of insulin secretion
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-77387 Insulin receptor recycling
R-HSA-977225 Amyloid fiber formation
SignaLinkiP01308
SIGNORiP01308

Miscellaneous databases

ChiTaRSiINS human
EvolutionaryTraceiP01308
GeneWikiiInsulin
GenomeRNAii3630
PMAP-CutDBiP01308
PROiPR:P01308
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell
ExpressionAtlasiP01308 baseline and differential
GenevisibleiP01308 HS

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINS_HUMAN
AccessioniPrimary (citable) accession number: P01308
Secondary accession number(s): Q5EEX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 240 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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