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UniProtKB - P01308 (INS_HUMAN)

Entry version 252 (11 Dec 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Insulin

Gene

INS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:MONOMER-16190

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-264876 Insulin processing
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
R-HSA-422356 Regulation of insulin secretion
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-77387 Insulin receptor recycling
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-977225 Amyloid fiber formation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P01308

SIGNOR Signaling Network Open Resource

More...SIGNORi		P01308

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
Insulin B chain
Insulin A chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000254647.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:6081 INS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176730 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01308

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperproinsulinemia (HPRI)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant condition characterized by elevated levels of serum proinsulin-like material.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00397134H → D in HPRI; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918101EnsemblClinVar.1
Natural variantiVAR_00397489R → H in HPRI; impairs post-translational cleavage. 2 PublicationsCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_00397589R → L in HPRI; Kyoto. 1 PublicationCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Diabetes mellitus, insulin-dependent, 2 (IDDM2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06373255R → C in IDDM2. 1 PublicationCorresponds to variant dbSNP:rs121908261EnsemblClinVar.1
Diabetes mellitus, permanent neonatal (PNDM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06372324A → D in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356663EnsemblClinVar.1
Natural variantiVAR_06372429H → D in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908272EnsemblClinVar.1
Natural variantiVAR_06372532G → R in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372632G → S in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372735L → P in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908273EnsemblClinVar.1
Natural variantiVAR_06372843C → G in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356666EnsemblClinVar.1
Natural variantiVAR_06373047G → V in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356667EnsemblClinVar.1
Natural variantiVAR_06373148F → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_06373484G → R in PNDM; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121908274EnsemblClinVar.1
Natural variantiVAR_06373589R → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356669EnsemblClinVar.1
Natural variantiVAR_06373690G → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356670EnsemblClinVar.1
Natural variantiVAR_06373796C → S in PNDM. 1 PublicationCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_06373896C → Y in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_063739101S → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908276EnsemblClinVar.1
Natural variantiVAR_063740103Y → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908277EnsemblClinVar.1
Natural variantiVAR_063741108Y → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356672EnsemblClinVar.1
Maturity-onset diabetes of the young 10 (MODY10)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637216R → C in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908278EnsemblClinVar.1
Natural variantiVAR_0637226R → H in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908259EnsemblClinVar.1
Natural variantiVAR_06372946R → Q in MODY10; reduces binding affinity to INSR; reduces biological activity; reduces folding properties. 3 PublicationsCorresponds to variant dbSNP:rs121908260EnsemblClinVar.1

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		3630

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		INS

MalaCards human disease database

More...MalaCardsi		INS
MIMi125852 phenotype
606176 phenotype
613370 phenotype
616214 phenotype

Open Targets

More...OpenTargetsi		ENSG00000254647

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		552 MODY
99885 Permanent neonatal diabetes mellitus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA201

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01308 Tbio

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		2121 Hom s Insulin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5881

Drug and drug target database

More...DrugBanki		DB01776 M-Cresol
DB08231 Myristic acid
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INS

Domain mapping of disease mutations (DMDM)

More...DMDMi		124617

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001581925 – 54Insulin B chainAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001582057 – 87C peptideAdd BLAST31
PeptideiPRO_000001582190 – 110Insulin A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 96Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi43 ↔ 109Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi95 ↔ 100Combined sources5 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P01308

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P01308

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01308

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01308

PeptideAtlas

More...PeptideAtlasi		P01308

PRoteomics IDEntifications database

More...PRIDEi		P01308

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51374 [P01308-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P01308

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01308

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01308

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P01308 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01308 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB000048
CAB012098
CAB053843
HPA004932

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds (PubMed:25423173).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109842, 14 interactors

Database of interacting proteins

More...DIPi		DIP-6024N

Protein interaction database and analysis system

More...IntActi		P01308, 17 interactors

Molecular INTeraction database

More...MINTi		P01308

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380432

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01308 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01308

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P01308

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J0XC Eukaryota
ENOG4111VJB LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015440

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000261669

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01308

KEGG Orthology (KO)

More...KOi		K04526

Identification of Orthologs from Complete Genome Data

More...OMAi		APPQHLC

Database of Orthologous Groups

More...OrthoDBi		1438615at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01308

TreeFam database of animal gene trees

More...TreeFami		TF332820

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family

The PANTHER Classification System

More...PANTHERi		PTHR11454 PTHR11454, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00049 Insulin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00277 INSULIN
PR00276 INSULINFAMLY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00078 IlGF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56994 SSF56994, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00262 INSULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P01308-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY 
        60         70         80         90        100
TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC 
       110
SLYQLENYCN
Length:110
Mass (Da):11,981
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2C3B23B85E520E5
GO
Isoform 2 (identifier: F8WCM5-1) [UniParc]FASTAAdd to basket
Also known as: INS-IGF2
The sequence of this isoform can be found in the external entry F8WCM5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:200
Mass (Da):21,537
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6XGL2A6XGL2_HUMAN
Insulin
INS
98Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNR5C9JNR5_HUMAN
Insulin
INS
92Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA59179 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637216R → C in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908278EnsemblClinVar.1
Natural variantiVAR_0637226R → H in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908259EnsemblClinVar.1
Natural variantiVAR_06372324A → D in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356663EnsemblClinVar.1
Natural variantiVAR_06372429H → D in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908272EnsemblClinVar.1
Natural variantiVAR_06372532G → R in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_06372632G → S in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar.1
Natural variantiVAR_00397134H → D in HPRI; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918101EnsemblClinVar.1
Natural variantiVAR_06372735L → P in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908273EnsemblClinVar.1
Natural variantiVAR_06372843C → G in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356666EnsemblClinVar.1
Natural variantiVAR_06372946R → Q in MODY10; reduces binding affinity to INSR; reduces biological activity; reduces folding properties. 3 PublicationsCorresponds to variant dbSNP:rs121908260EnsemblClinVar.1
Natural variantiVAR_06373047G → V in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356667EnsemblClinVar.1
Natural variantiVAR_06373148F → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_00397248F → S Associated with diabetes mellitus type-II; Los-Angeles. 3 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar.1
Natural variantiVAR_00397349F → L in Chicago. 1 PublicationCorresponds to variant dbSNP:rs148685531EnsemblClinVar.1
Natural variantiVAR_06373255R → C in IDDM2. 1 PublicationCorresponds to variant dbSNP:rs121908261EnsemblClinVar.1
Natural variantiVAR_06373368L → M1 PublicationCorresponds to variant dbSNP:rs121908279EnsemblClinVar.1
Natural variantiVAR_06373484G → R in PNDM; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121908274EnsemblClinVar.1
Natural variantiVAR_06373589R → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356669EnsemblClinVar.1
Natural variantiVAR_00397489R → H in HPRI; impairs post-translational cleavage. 2 PublicationsCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_00397589R → L in HPRI; Kyoto. 1 PublicationCorresponds to variant dbSNP:rs28933985EnsemblClinVar.1
Natural variantiVAR_06373690G → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356670EnsemblClinVar.1
Natural variantiVAR_00397692V → L in Wakayama. 1 PublicationCorresponds to variant dbSNP:rs121918102EnsemblClinVar.1
Natural variantiVAR_06373796C → S in PNDM. 1 PublicationCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_06373896C → Y in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356671EnsemblClinVar.1
Natural variantiVAR_063739101S → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908276EnsemblClinVar.1
Natural variantiVAR_063740103Y → C in PNDM. 1 PublicationCorresponds to variant dbSNP:rs121908277EnsemblClinVar.1
Natural variantiVAR_063741108Y → C in PNDM. 2 PublicationsCorresponds to variant dbSNP:rs80356672EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
V00565 Genomic DNA Translation: CAA23828.1
M10039 Genomic DNA Translation: AAA59173.1
J00265 Genomic DNA Translation: AAA59172.1
X70508 mRNA Translation: CAA49913.1
L15440 Genomic DNA Translation: AAA59179.1 Sequence problems.
AY899304 mRNA Translation: AAW83741.1
AY138590 Genomic DNA Translation: AAN39451.1
BT006808 mRNA Translation: AAP35454.1
CH471158 Genomic DNA Translation: EAX02488.1
BC005255 mRNA Translation: AAH05255.1
AJ009655 Genomic DNA Translation: CAA08766.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7729.1 [P01308-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A93222 IPHU

NCBI Reference Sequences

More...RefSeqi		NP_000198.1, NM_000207.2 [P01308-1]
NP_001172026.1, NM_001185097.1 [P01308-1]
NP_001172027.1, NM_001185098.1 [P01308-1]
NP_001278826.1, NM_001291897.1 [P01308-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000250971; ENSP00000250971; ENSG00000254647 [P01308-1]
ENST00000381330; ENSP00000370731; ENSG00000254647 [P01308-1]
ENST00000397262; ENSP00000380432; ENSG00000254647 [P01308-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3630

UCSC genome browser

More...UCSCi		uc001lvn.3 human [P01308-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Insulin at Eli Lilly

Clinical information on Eli Lilly insulin products

Protein Spotlight

Protein of the 20th century - Issue 9 of April 2001

Wikipedia

Insulin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00565 Genomic DNA Translation: CAA23828.1
M10039 Genomic DNA Translation: AAA59173.1
J00265 Genomic DNA Translation: AAA59172.1
X70508 mRNA Translation: CAA49913.1
L15440 Genomic DNA Translation: AAA59179.1 Sequence problems.
AY899304 mRNA Translation: AAW83741.1
AY138590 Genomic DNA Translation: AAN39451.1
BT006808 mRNA Translation: AAP35454.1
CH471158 Genomic DNA Translation: EAX02488.1
BC005255 mRNA Translation: AAH05255.1
AJ009655 Genomic DNA Translation: CAA08766.1
CCDSiCCDS7729.1 [P01308-1]
PIRiA93222 IPHU
RefSeqiNP_000198.1, NM_000207.2 [P01308-1]
NP_001172026.1, NM_001185097.1 [P01308-1]
NP_001172027.1, NM_001185098.1 [P01308-1]
NP_001278826.1, NM_001291897.1 [P01308-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7FNMR-A90-110[»]
B25-53[»]
1AI0NMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1B9EX-ray2.50A/C90-110[»]
B/D25-54[»]
1BENX-ray1.40A/C90-110[»]
B/D25-54[»]
1EFENMR-A25-54[»]
A90-110[»]
1EV3X-ray1.78A/C90-110[»]
B/D25-54[»]
1EV6X-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1EVRX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1FU2X-ray3.24A/C/E/G90-110[»]
B/D/F/H25-54[»]
1FUBX-ray3.09A/C90-110[»]
B/D25-54[»]
1G7AX-ray1.20A/C/E/G90-110[»]
B/D/F/H25-54[»]
1G7BX-ray1.30A/C/E/G90-110[»]
B/D/F/H25-54[»]
1GUJX-ray1.62A/C90-110[»]
B/D25-54[»]
1HIQNMR-A90-110[»]
B25-54[»]
1HISNMR-A90-110[»]
B25-49[»]
1HITNMR-A90-110[»]
B25-54[»]
1HLSNMR-A90-110[»]
B25-54[»]
1HTVX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-51[»]
1HUINMR-A90-110[»]
B26-53[»]
1IOGNMR-A90-110[»]
B25-53[»]
1IOHNMR-A90-110[»]
B25-53[»]
1J73X-ray2.00A/C90-110[»]
B/D25-54[»]
1JCAX-ray2.50A/C90-110[»]
B/D25-54[»]
1JCONMR-A90-110[»]
B25-54[»]
1JK8X-ray2.40C35-47[»]
1K3MNMR-A90-110[»]
B25-54[»]
1KMFNMR-A90-110[»]
B25-54[»]
1LKQNMR-A90-110[»]
B25-54[»]
1LPHX-ray2.30A/C90-110[»]
B/D25-54[»]
1MHINMR-A90-110[»]
B25-54[»]
1MHJNMR-A90-110[»]
B25-54[»]
1MSOX-ray1.00A/C90-110[»]
B/D25-54[»]
1OS3X-ray1.95A/C90-110[»]
B/D25-54[»]
1OS4X-ray2.25A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1Q4VX-ray2.00A/C90-110[»]
B/D25-54[»]
1QIYX-ray2.30A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1QIZX-ray2.00A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1QJ0X-ray2.40A/C90-110[»]
B/D25-54[»]
1RWEX-ray1.80A/C90-110[»]
B/D25-54[»]
1SF1NMR-A90-110[»]
B25-54[»]
1SJTNMR-A90-110[»]
B25-51[»]
1SJUNMR-A25-110[»]
1T0CNMR-A57-87[»]
1T1KNMR-A90-110[»]
B25-54[»]
1T1PNMR-A90-110[»]
B25-54[»]
1T1QNMR-A90-110[»]
B25-54[»]
1TRZX-ray1.60A/C90-110[»]
B/D25-54[»]
1TYLX-ray1.90A/C90-110[»]
B/D25-54[»]
1TYMX-ray1.90A/C90-110[»]
B/D25-54[»]
1UZ9X-ray1.60A90-110[»]
B25-53[»]
1VKTNMR-A90-110[»]
B25-54[»]
1W8PX-ray2.08A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
1XDAX-ray1.80A/C/E/G90-110[»]
B/D/F/H25-53[»]
1XGLNMR-A90-110[»]
B25-54[»]
1XW7X-ray2.30A/C90-110[»]
B/D25-54[»]
1ZEGX-ray1.60A/C90-110[»]
B/D25-54[»]
1ZEHX-ray1.50A/C90-110[»]
B/D25-54[»]
1ZNJX-ray2.00A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2C8QX-ray1.95A90-110[»]
B25-53[»]
2C8RX-ray1.50A90-110[»]
B25-53[»]
2CEUX-ray1.80A/C90-110[»]
B/D25-49[»]
2G54X-ray2.25C/D25-54[»]
2G56X-ray2.20C/D25-54[»]
2H67NMR-A90-110[»]
B25-54[»]
2HH4NMR-A90-110[»]
B25-54[»]
2HHONMR-A90-110[»]
B25-54[»]
2HIUNMR-A90-110[»]
B25-54[»]
2JMNNMR-A90-110[»]
B25-54[»]
2JUMNMR-A90-110[»]
B25-54[»]
2JUUNMR-A90-110[»]
B25-54[»]
2JUVNMR-A90-110[»]
B25-54[»]
2JV1NMR-A90-110[»]
B25-54[»]
2JZQNMR-A25-54[»]
A90-110[»]
2K91NMR-A90-110[»]
B25-54[»]
2K9RNMR-A90-110[»]
B25-54[»]
2KJJNMR-A90-110[»]
B25-54[»]
2KJUNMR-A90-110[»]
B25-54[»]
2KQPNMR-A25-110[»]
2KQQNMR-A90-110[»]
B25-54[»]
2KXKNMR-A90-110[»]
B25-54[»]
2L1YNMR-A90-110[»]
B25-54[»]
2L1ZNMR-A90-110[»]
B25-54[»]
2LGBNMR-A90-110[»]
B25-55[»]
2LWZNMR-A25-54[»]
A89-110[»]
2M1DNMR-A90-110[»]
B25-54[»]
2M1ENMR-A90-110[»]
B25-54[»]
2M2MNMR-A90-110[»]
B25-54[»]
2M2NNMR-A90-110[»]
B25-54[»]
2M2ONMR-A90-110[»]
B25-54[»]
2M2PNMR-A90-110[»]
B25-54[»]
2MLINMR-A90-110[»]
B25-54[»]
2MPGNMR-A90-110[»]
B25-54[»]
2MPINMR-A90-110[»]
B25-54[»]
2MVCNMR-A90-110[»]
B25-54[»]
2MVDNMR-A90-110[»]
B25-54[»]
2N2VNMR-A90-110[»]
B25-54[»]
2N2WNMR-A90-110[»]
B25-54[»]
2N2XNMR-A90-110[»]
B25-54[»]
2OLYX-ray1.70A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OLZX-ray1.70A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OM0X-ray2.051/3/A/C/E/G/I/K/Q/S/U/X/a/c/e/g/i/k90-110[»]
2/4/B/D/F/H/J/L/R/T/V/Y/b/d/f/h/j/l25-54[»]
2OM1X-ray1.971/3/A/C/E/G/I/K/Q/S/U/X/a/c/e/g/i/k90-110[»]
2/4/B/D/F/H/J/L/R/T/V/Y/b/d/f/h/j/l25-54[»]
2OMGX-ray1.52A/C/E90-110[»]
B/D/F25-54[»]
2OMHX-ray1.36A/C/E90-110[»]
B/D/F25-54[»]
2OMIX-ray2.24A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2OMQX-ray2.00A/B/C/D36-41[»]
2QIUX-ray2.00A/C89-110[»]
B/D25-54[»]
2R34X-ray2.25A/C89-110[»]
B/D25-54[»]
2R35X-ray2.08A/C89-110[»]
B/D25-54[»]
2R36X-ray2.00A/C89-110[»]
B/D25-54[»]
2RN5NMR-A90-110[»]
B25-54[»]
2VJZX-ray1.80A/C90-110[»]
B/D25-54[»]
2VK0X-ray2.20A/C90-110[»]
B/D25-54[»]
2W44X-ray2.00A/C/E94-110[»]
B/D/F25-53[»]
2WBYX-ray2.60C/E90-109[»]
D/F25-43[»]
2WC0X-ray2.80C/E90-110[»]
D/F25-54[»]
2WRUX-ray1.57A90-110[»]
B25-50[»]
2WRVX-ray2.15A90-110[»]
B25-50[»]
2WRWX-ray2.41A90-110[»]
B25-50[»]
2WRXX-ray1.50A/C90-110[»]
B/D25-54[»]
2WS0X-ray2.10A90-110[»]
B25-54[»]
2WS1X-ray1.60A90-110[»]
B25-54[»]
2WS4X-ray1.90A90-110[»]
B25-50[»]
2WS6X-ray1.50A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
2WS7X-ray2.59A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-50[»]
3AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
3BXQX-ray1.30A/C90-110[»]
B/D25-54[»]
3E7YX-ray1.60A/C90-110[»]
B/D25-53[»]
3E7ZX-ray1.70A/C90-110[»]
B/D25-53[»]
3EXXX-ray1.35A/C90-110[»]
B/D25-54[»]
3FQ9X-ray1.35A/C91-110[»]
B/D25-54[»]
3HYDX-ray1.00A35-41[»]
3I3ZX-ray1.60A90-110[»]
B25-54[»]
3I40X-ray1.85A90-110[»]
B25-54[»]
3ILGX-ray1.90A/C90-110[»]
B/D25-54[»]
3INCX-ray1.85A/C90-110[»]
B/D25-54[»]
3IR0X-ray2.20A/C/E/G/I/K/M/O/R/T/V/X90-110[»]
B/D/F/H/J/L/N/P/S/U/W/Y25-54[»]
3JSDX-ray2.50A/C90-110[»]
B/D25-54[»]
3KQ6X-ray1.90A/C90-110[»]
B/D25-54[»]
3P2XX-ray2.00A/C90-110[»]
B/D25-54[»]
3P33X-ray2.30A/C/E/G90-110[»]
B/D/F/H25-54[»]
3Q6EX-ray2.05A/C90-110[»]
B/D25-54[»]
3ROVX-ray2.30A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
3TT8X-ray1.12A/C90-110[»]
B/D25-54[»]
3U4NX-ray1.98A90-110[»]
B25-53[»]
3UTQX-ray1.67C15-24[»]
3UTSX-ray2.71C/H15-24[»]
3UTTX-ray2.60C/H15-24[»]
3V19X-ray2.00A/C90-110[»]
B/D25-54[»]
3V1GX-ray2.20A/C90-110[»]
B/D25-54[»]
3W11X-ray3.90A90-110[»]
B25-54[»]
3W12X-ray4.30A90-110[»]
B25-50[»]
3W13X-ray4.30A90-110[»]
B25-50[»]
3W7YX-ray0.92A/C90-110[»]
B/D25-54[»]
3W7ZX-ray1.15A/C90-110[»]
B/D25-54[»]
3W80X-ray1.40A/C/E/G90-110[»]
B/D/F/H25-54[»]
3ZI3X-ray1.70A90-110[»]
B25-54[»]
3ZQRX-ray1.90A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
3ZS2X-ray1.97A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
3ZU1X-ray1.60A/C90-110[»]
B/D25-54[»]
4AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
4AJXX-ray1.20A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-53[»]
4AJZX-ray1.80A/C90-110[»]
B/D25-53[»]
4AK0X-ray2.28A90-110[»]
B25-53[»]
4AKJX-ray2.01A/C90-110[»]
B/D25-53[»]
4CXLX-ray1.50A90-110[»]
B25-54[»]
4CXNX-ray1.70A90-110[»]
B25-54[»]
4CY7X-ray1.40A/C90-110[»]
B/D25-54[»]
4EFXX-ray1.98A/C90-110[»]
B/D25-52[»]
4EWWX-ray2.30A/C90-110[»]
B/D25-54[»]
4EWXX-ray2.20A/C90-110[»]
B/D25-54[»]
4EWZX-ray1.79A/C90-110[»]
B/D25-54[»]
4EX0X-ray1.86A/C90-110[»]
B/D25-54[»]
4EX1X-ray1.66A/C90-110[»]
B/D25-54[»]
4EXXX-ray1.55A/C90-110[»]
B/D25-54[»]
4EY1X-ray1.47A/C90-110[»]
B/D25-54[»]
4EY9X-ray1.47A/C90-110[»]
B/D25-54[»]
4EYDX-ray1.47A/C90-110[»]
B/D25-54[»]
4EYNX-ray1.53A/C90-110[»]
B/D25-54[»]
4EYPX-ray1.59A/C90-110[»]
B/D25-54[»]
4F0NX-ray1.68A/C90-110[»]
B/D25-54[»]
4F0OX-ray1.67A/C90-110[»]
B/D25-54[»]
4F1AX-ray1.80A/C90-110[»]
B/D25-54[»]
4F1BX-ray1.59A/C90-110[»]
B/D25-54[»]
4F1CX-ray1.70A/C90-110[»]
B/D25-54[»]
4F1DX-ray1.64A/C90-110[»]
B/D25-54[»]
4F1FX-ray1.68A/C90-110[»]
B/D25-54[»]
4F1GX-ray1.64A/C90-110[»]
B/D25-54[»]
4F4TX-ray1.64A/C90-110[»]
B/D25-54[»]
4F4VX-ray1.64A/C90-110[»]
B/D25-54[»]
4F51X-ray1.64A/C90-110[»]
B/D25-54[»]
4F8FX-ray1.68A/C90-110[»]
B/D25-54[»]
4FG3X-ray2.00A/C90-110[»]
B/D25-54[»]
4FKAX-ray1.08A/C90-110[»]
B/D25-54[»]
4GBCX-ray1.78A/C90-110[»]
B/D25-54[»]
4GBIX-ray2.50A/C90-110[»]
B/D25-54[»]
4GBKX-ray2.40A/C90-110[»]
B/D25-54[»]
4GBLX-ray2.50A/C90-110[»]
B/D25-54[»]
4GBNX-ray1.87A/C90-110[»]
B/D25-54[»]
4IUZX-ray1.60A90-110[»]
B25-54[»]
4IYDX-ray1.66A90-109[»]
B25-53[»]
4IYFX-ray1.80A90-109[»]
B25-53[»]
4NIBX-ray1.40A90-110[»]
B25-54[»]
4OGAX-ray3.50A90-110[»]
B25-54[»]
4P65X-ray1.50A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
4RXWX-ray1.73A/C90-110[»]
B/D25-54[»]
4UNEX-ray1.59A/C90-110[»]
B/D25-54[»]
4UNGX-ray1.81A/C90-110[»]
B/D25-54[»]
4UNHX-ray2.75A90-110[»]
B25-54[»]
4WDIX-ray2.31C/F39-47[»]
4XC4X-ray1.50A/C90-110[»]
B/D25-54[»]
4Y19X-ray2.50C75-90[»]
4Y1AX-ray4.00C75-90[»]
4Z76X-ray1.88C/F39-46[»]
4Z77X-ray1.85C/F39-47[»]
4Z78X-ray2.30C/F/I39-48[»]
5AIYNMR-A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
5BOQX-ray1.70A/C/E/G90-110[»]
B/D/F/H25-54[»]
5BPOX-ray1.90A/C90-110[»]
B/D25-54[»]
5BQQX-ray1.54A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-50[»]
5BTSX-ray1.77A90-110[»]
B25-54[»]
5C0DX-ray1.68C15-24[»]
5CJOX-ray3.29a90-109[»]
5CNYX-ray1.70A/C90-110[»]
B/D25-54[»]
5CO2X-ray1.70A/C90-110[»]
B/D25-54[»]
5CO6X-ray1.80A/C90-110[»]
B/D25-54[»]
5CO9X-ray1.92A/C90-110[»]
B/D25-54[»]
5E7WX-ray0.95A/C90-110[»]
B/D25-54[»]
5EMSX-ray2.30A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-52[»]
5EN9X-ray1.50A90-110[»]
B25-54[»]
5ENAX-ray1.35A90-110[»]
B25-54[»]
5HPRX-ray1.33A90-110[»]
B25-54[»]
5HPUX-ray2.20A/C90-110[»]
B/D25-54[»]
5HQIX-ray0.97A90-110[»]
B25-54[»]
5HRQX-ray1.28A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
5HYJX-ray3.06C/H15-24[»]
5MAMX-ray2.200/2/4/A/C/E/G/I/K/M/O/Q/S/U/W/Y90-110[»]
1/3/5/B/D/F/H/J/L/N/P/R/T/V/X/Z25-54[»]
5MHDNMR-A90-110[»]
B25-55[»]
5MT3X-ray2.02A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e90-110[»]
B/D/F/H/J/L/N/P/R/T/V/X/Z/b/d/f25-54[»]
5MT9X-ray1.88A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e90-110[»]
B/D/F/H/J/L/N/P/R/T/V/X/Z/b/d/f25-54[»]
5MWQNMR-A90-110[»]
B25-56[»]
5T7RX-ray1.55A/C90-110[»]
B/D25-54[»]
5UDPX-ray1.35A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
5UOZX-ray1.17A90-110[»]
B25-54[»]
5UQAX-ray1.31A/C/E/G/I/K90-110[»]
B/D/F/H/J/L25-54[»]
5URTX-ray1.18A90-110[»]
B25-54[»]
5URUX-ray2.41A/C/E/G90-110[»]
B/D/F/H25-54[»]
5USPX-ray1.17A90-110[»]
B25-54[»]
5USSX-ray2.06A/C90-110[»]
B/D25-54[»]
5USVX-ray1.30A90-110[»]
B25-54[»]
5UU2X-ray1.22A90-110[»]
B25-54[»]
5UU3X-ray2.25A/C/E/G/I/K/M/O/Q/S/U/W90-110[»]
B/D/F/H/J/L/N/P/R/T/V/X25-54[»]
5UU4X-ray1.97A/C90-110[»]
B/D25-54[»]
5VIZX-ray1.70A90-109[»]
B25-53[»]
5WBTNMR-A25-54[»]
A90-110[»]
5WDMX-ray2.80A/B/C/D/E/F25-110[»]
5WOBX-ray3.95a/b/c/d/e/f/g/h90-109[»]
6B3Qelectron microscopy3.70a/b1-110[»]
6B70electron microscopy3.70a/c1-110[»]
6BFCelectron microscopy3.70a/b1-110[»]
6CE7electron microscopy7.40N90-110[»]
6CE9electron microscopy4.30K/N90-110[»]
6CEBelectron microscopy4.70K/N90-110[»]
6CK2X-ray2.25A/C90-110[»]
B/D25-54[»]
6GNQX-ray2.20A/C/E/G/I/K/M/O/Q/S/U/W90-110[»]
B/D/F/H/J/L/N/P/R/T/V/X25-54[»]
6GV0X-ray1.26B/D25-54[»]
G/I90-110[»]
6H3MX-ray1.82A/C/E/G/I/K/N/R90-110[»]
B/D/F/H/J/L/P/Q25-54[»]
6HN5electron microscopy3.20A90-110[»]
B25-54[»]
6P4ZX-ray1.80A/C90-110[»]
B/D25-54[»]
6S34X-ray1.35A90-110[»]
B25-54[»]
SMRiP01308
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109842, 14 interactors
DIPiDIP-6024N
IntActiP01308, 17 interactors
MINTiP01308
STRINGi9606.ENSP00000380432

Chemistry databases

ChEMBLiCHEMBL5881
DrugBankiDB01776 M-Cresol
DB08231 Myristic acid
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Protein family/group databases

Allergomei2121 Hom s Insulin

PTM databases

CarbonylDBiP01308
iPTMnetiP01308
PhosphoSitePlusiP01308

Polymorphism and mutation databases

BioMutaiINS
DMDMi124617

Proteomic databases

EPDiP01308
jPOSTiP01308
MassIVEiP01308
PaxDbiP01308
PeptideAtlasiP01308
PRIDEiP01308
ProteomicsDBi51374 [P01308-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P01308

The DNASU plasmid repository

More...DNASUi		3630

Genome annotation databases

EnsembliENST00000250971; ENSP00000250971; ENSG00000254647 [P01308-1]
ENST00000381330; ENSP00000370731; ENSG00000254647 [P01308-1]
ENST00000397262; ENSP00000380432; ENSG00000254647 [P01308-1]
GeneIDi3630
KEGGihsa:3630
UCSCiuc001lvn.3 human [P01308-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3630
DisGeNETi3630
EuPathDBiHostDB:ENSG00000254647.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		INS
GeneReviewsiINS
HGNCiHGNC:6081 INS
HPAiCAB000048
CAB012098
CAB053843
HPA004932
MalaCardsiINS
MIMi125852 phenotype
176730 gene
606176 phenotype
613370 phenotype
616214 phenotype
neXtProtiNX_P01308
OpenTargetsiENSG00000254647
Orphaneti552 MODY
99885 Permanent neonatal diabetes mellitus
PharmGKBiPA201

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
InParanoidiP01308
KOiK04526
OMAiAPPQHLC
OrthoDBi1438615at2759
PhylomeDBiP01308
TreeFamiTF332820

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16190
ReactomeiR-HSA-210745 Regulation of gene expression in beta cells
R-HSA-264876 Insulin processing
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
R-HSA-422356 Regulation of insulin secretion
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-77387 Insulin receptor recycling
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-977225 Amyloid fiber formation
SignaLinkiP01308
SIGNORiP01308

Miscellaneous databases

EvolutionaryTraceiP01308

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Insulin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3630
PharosiP01308 Tbio

Protein Ontology

More...PROi		PR:P01308
RNActiP01308 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000254647 Expressed in 72 organ(s), highest expression level in type B pancreatic cell
ExpressionAtlasiP01308 baseline and differential
GenevisibleiP01308 HS

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PANTHERiPTHR11454 PTHR11454, 1 hit
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01308
Secondary accession number(s): Q5EEX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 11, 2019
This is version 252 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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