UniProtKB - P01308 (INS_HUMAN)
Insulin
INS
Functioni
GO - Molecular functioni
- hormone activity Source: BHF-UCL
- identical protein binding Source: IntAct
- insulin-like growth factor receptor binding Source: BHF-UCL
- insulin receptor binding Source: UniProtKB
- protease binding Source: UniProtKB
GO - Biological processi
- activation of protein kinase B activity Source: BHF-UCL
- acute-phase response Source: BHF-UCL
- alpha-beta T cell activation Source: UniProtKB
- cell-cell signaling Source: UniProtKB
- cellular protein metabolic process Source: Reactome
- cognition Source: ARUK-UCL
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- fatty acid homeostasis Source: BHF-UCL
- glucose homeostasis Source: BHF-UCL
- glucose metabolic process Source: UniProtKB-KW
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- insulin receptor signaling pathway Source: BHF-UCL
- negative regulation of acute inflammatory response Source: BHF-UCL
- negative regulation of blood vessel diameter Source: UniProtKB
- negative regulation of fatty acid metabolic process Source: BHF-UCL
- negative regulation of feeding behavior Source: DFLAT
- negative regulation of gluconeogenesis Source: BHF-UCL
- negative regulation of glycogen catabolic process Source: BHF-UCL
- negative regulation of lipid catabolic process Source: AgBase
- negative regulation of NAD(P)H oxidase activity Source: BHF-UCL
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of protein catabolic process Source: UniProtKB
- negative regulation of protein secretion Source: BHF-UCL
- negative regulation of proteolysis Source: BHF-UCL
- negative regulation of reactive oxygen species biosynthetic process Source: ARUK-UCL
- negative regulation of respiratory burst involved in inflammatory response Source: BHF-UCL
- neuron projection maintenance Source: ARUK-UCL
- positive regulation of blood vessel diameter Source: UniProtKB
- positive regulation of brown fat cell differentiation Source: BHF-UCL
- positive regulation of cell differentiation Source: BHF-UCL
- positive regulation of cell growth Source: BHF-UCL
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of cellular protein metabolic process Source: BHF-UCL
- positive regulation of cytokine production Source: UniProtKB
- positive regulation of dendritic spine maintenance Source: ARUK-UCL
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of glucose import Source: UniProtKB
- positive regulation of glycogen biosynthetic process Source: BHF-UCL
- positive regulation of glycolytic process Source: BHF-UCL
- positive regulation of insulin receptor signaling pathway Source: UniProtKB
- positive regulation of lipid biosynthetic process Source: BHF-UCL
- positive regulation of long-term synaptic potentiation Source: ARUK-UCL
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of mitotic nuclear division Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
- positive regulation of nitric oxide mediated signal transduction Source: UniProtKB
- positive regulation of nitric-oxide synthase activity Source: UniProtKB
- positive regulation of peptide hormone secretion Source: BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of protein autophosphorylation Source: BHF-UCL
- positive regulation of protein kinase B signaling Source: BHF-UCL
- positive regulation of protein localization to nucleus Source: BHF-UCL
- positive regulation of respiratory burst Source: BHF-UCL
- regulation of cellular amino acid metabolic process Source: BHF-UCL
- regulation of protein localization Source: BHF-UCL
- regulation of protein localization to plasma membrane Source: ARUK-UCL
- regulation of protein secretion Source: UniProtKB
- regulation of synaptic plasticity Source: ARUK-UCL
- regulation of transcription, DNA-templated Source: BHF-UCL
- regulation of transmembrane transporter activity Source: BHF-UCL
- wound healing Source: BHF-UCL
Keywordsi
Molecular function | Hormone |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-16190 |
PathwayCommonsi | P01308 |
Reactomei | R-HSA-210745, Regulation of gene expression in beta cells R-HSA-264876, Insulin processing R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin R-HSA-422356, Regulation of insulin secretion R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-74713, IRS activation R-HSA-74749, Signal attenuation R-HSA-74751, Insulin receptor signalling cascade R-HSA-74752, Signaling by Insulin receptor R-HSA-77387, Insulin receptor recycling R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-977225, Amyloid fiber formation |
SignaLinki | P01308 |
SIGNORi | P01308 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:INS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6081, INS |
MIMi | 176730, gene |
neXtProti | NX_P01308 |
VEuPathDBi | HostDB:ENSG00000254647.6 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Endosome
- endosome lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi lumen Source: Reactome
- Golgi membrane Source: Reactome
Other locations
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
- secretory granule lumen Source: Reactome
- transport vesicle Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Hyperproinsulinemia (HPRI)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003971 | 34 | H → D in HPRI; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918101EnsemblClinVar. | 1 | |
Natural variantiVAR_003974 | 89 | R → H in HPRI; impairs post-translational cleavage. 2 PublicationsCorresponds to variant dbSNP:rs28933985EnsemblClinVar. | 1 | |
Natural variantiVAR_003975 | 89 | R → L in HPRI; Kyoto. 1 PublicationCorresponds to variant dbSNP:rs28933985EnsemblClinVar. | 1 |
Diabetes mellitus, insulin-dependent, 2 (IDDM2)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063732 | 55 | R → C in IDDM2. 1 PublicationCorresponds to variant dbSNP:rs121908261EnsemblClinVar. | 1 |
Diabetes mellitus, permanent neonatal 4 (PNDM4)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063723 | 24 | A → D in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356663EnsemblClinVar. | 1 | |
Natural variantiVAR_063724 | 29 | H → D in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs121908272EnsemblClinVar. | 1 | |
Natural variantiVAR_063725 | 32 | G → R in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar. | 1 | |
Natural variantiVAR_063726 | 32 | G → S in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar. | 1 | |
Natural variantiVAR_063727 | 35 | L → P in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs121908273EnsemblClinVar. | 1 | |
Natural variantiVAR_063728 | 43 | C → G in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356666EnsemblClinVar. | 1 | |
Natural variantiVAR_063730 | 47 | G → V in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356667EnsemblClinVar. | 1 | |
Natural variantiVAR_063731 | 48 | F → C in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar. | 1 | |
Natural variantiVAR_063734 | 84 | G → R in PNDM4; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121908274EnsemblClinVar. | 1 | |
Natural variantiVAR_063735 | 89 | R → C in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356669EnsemblClinVar. | 1 | |
Natural variantiVAR_063736 | 90 | G → C in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356670EnsemblClinVar. | 1 | |
Natural variantiVAR_063737 | 96 | C → S in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs80356671EnsemblClinVar. | 1 | |
Natural variantiVAR_063738 | 96 | C → Y in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356671EnsemblClinVar. | 1 | |
Natural variantiVAR_063739 | 101 | S → C in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs121908276EnsemblClinVar. | 1 | |
Natural variantiVAR_063740 | 103 | Y → C in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs121908277EnsemblClinVar. | 1 | |
Natural variantiVAR_063741 | 108 | Y → C in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356672EnsemblClinVar. | 1 |
Maturity-onset diabetes of the young 10 (MODY10)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063721 | 6 | R → C in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908278EnsemblClinVar. | 1 | |
Natural variantiVAR_063722 | 6 | R → H in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908259EnsemblClinVar. | 1 | |
Natural variantiVAR_063729 | 46 | R → Q in MODY10; reduces binding affinity to INSR; reduces biological activity; reduces folding properties. 3 PublicationsCorresponds to variant dbSNP:rs121908260EnsemblClinVar. | 1 |
Pharmaceutical usei
Keywords - Diseasei
Diabetes mellitus, Disease variantOrganism-specific databases
DisGeNETi | 3630 |
GeneReviewsi | INS |
MalaCardsi | INS |
MIMi | 125852, phenotype 613370, phenotype 616214, phenotype 618858, phenotype |
OpenTargetsi | ENSG00000254647 |
Orphaneti | 552, MODY 99885, Permanent neonatal diabetes mellitus |
PharmGKBi | PA201 |
Miscellaneous databases
Pharosi | P01308, Tbio |
Protein family/group databases
Allergomei | 2121, Hom s Insulin |
Chemistry databases
ChEMBLi | CHEMBL5881 |
DrugBanki | DB01776, M-Cresol DB08231, Myristic acid DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | INS |
DMDMi | 124617 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_0000015819 | 25 – 54 | Insulin B chainAdd BLAST | 30 | |
PropeptideiPRO_0000015820 | 57 – 87 | C peptideAdd BLAST | 31 | |
PeptideiPRO_0000015821 | 90 – 110 | Insulin A chainAdd BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 96 | Interchain (between B and A chains)Combined sources3 Publications | ||
Disulfide bondi | 43 ↔ 109 | Interchain (between B and A chains)Combined sources3 Publications | ||
Disulfide bondi | 95 ↔ 100 | Combined sources5 Publications |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
EPDi | P01308 |
jPOSTi | P01308 |
MassIVEi | P01308 |
PaxDbi | P01308 |
PeptideAtlasi | P01308 |
PRIDEi | P01308 |
ProteomicsDBi | 51374 [P01308-1] |
PTM databases
CarbonylDBi | P01308 |
iPTMneti | P01308 |
PhosphoSitePlusi | P01308 |
Expressioni
Gene expression databases
Bgeei | ENSG00000254647, Expressed in type B pancreatic cell and 95 other tissues |
ExpressionAtlasi | P01308, baseline and differential |
Genevisiblei | P01308, HS |
Organism-specific databases
HPAi | ENSG00000254647, Tissue enriched (pancreas) |
Interactioni
Subunit structurei
Heterodimer of a B chain and an A chain linked by two disulfide bonds (PubMed:25423173).
1 PublicationBinary interactionsi
Hide detailsP01308
P01308 (PRO_0000015820)
With | #Exp. | IntAct |
---|---|---|
HSPA8 [P11142] | 2 | EBI-20765227,EBI-351896 |
GO - Molecular functioni
- hormone activity Source: BHF-UCL
- identical protein binding Source: IntAct
- insulin-like growth factor receptor binding Source: BHF-UCL
- insulin receptor binding Source: UniProtKB
- protease binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109842, 24 interactors |
DIPi | DIP-6024N |
IntActi | P01308, 18 interactors |
MINTi | P01308 |
STRINGi | 9606.ENSP00000380432 |
Miscellaneous databases
RNActi | P01308, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P01308 |
PCDDBi | P01308 |
SASBDBi | P01308 |
SMRi | P01308 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01308 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S5P5, Eukaryota |
GeneTreei | ENSGT00390000015440 |
InParanoidi | P01308 |
OMAi | APPQHLC |
PhylomeDBi | P01308 |
TreeFami | TF332820 |
Family and domain databases
CDDi | cd04367, IlGF_insulin_like, 1 hit |
InterProi | View protein in InterPro IPR004825, Insulin IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR022353, Insulin_CS IPR022352, Insulin_family |
PANTHERi | PTHR11454, PTHR11454, 1 hit |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
PRINTSi | PR00277, INSULIN PR00276, INSULINFAMLY |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC
110
SLYQLENYCN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6XGL2 | A6XGL2_HUMAN | Insulin | INS | 98 | Annotation score: | ||
C9JNR5 | C9JNR5_HUMAN | Insulin | INS | 92 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063721 | 6 | R → C in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908278EnsemblClinVar. | 1 | |
Natural variantiVAR_063722 | 6 | R → H in MODY10. 1 PublicationCorresponds to variant dbSNP:rs121908259EnsemblClinVar. | 1 | |
Natural variantiVAR_063723 | 24 | A → D in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356663EnsemblClinVar. | 1 | |
Natural variantiVAR_063724 | 29 | H → D in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs121908272EnsemblClinVar. | 1 | |
Natural variantiVAR_063725 | 32 | G → R in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar. | 1 | |
Natural variantiVAR_063726 | 32 | G → S in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356664EnsemblClinVar. | 1 | |
Natural variantiVAR_003971 | 34 | H → D in HPRI; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918101EnsemblClinVar. | 1 | |
Natural variantiVAR_063727 | 35 | L → P in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs121908273EnsemblClinVar. | 1 | |
Natural variantiVAR_063728 | 43 | C → G in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356666EnsemblClinVar. | 1 | |
Natural variantiVAR_063729 | 46 | R → Q in MODY10; reduces binding affinity to INSR; reduces biological activity; reduces folding properties. 3 PublicationsCorresponds to variant dbSNP:rs121908260EnsemblClinVar. | 1 | |
Natural variantiVAR_063730 | 47 | G → V in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356667EnsemblClinVar. | 1 | |
Natural variantiVAR_063731 | 48 | F → C in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar. | 1 | |
Natural variantiVAR_003972 | 48 | F → S Associated with diabetes mellitus type-II; Los-Angeles. 3 PublicationsCorresponds to variant dbSNP:rs80356668EnsemblClinVar. | 1 | |
Natural variantiVAR_003973 | 49 | F → L in Chicago. 1 PublicationCorresponds to variant dbSNP:rs148685531EnsemblClinVar. | 1 | |
Natural variantiVAR_063732 | 55 | R → C in IDDM2. 1 PublicationCorresponds to variant dbSNP:rs121908261EnsemblClinVar. | 1 | |
Natural variantiVAR_063733 | 68 | L → M1 PublicationCorresponds to variant dbSNP:rs121908279EnsemblClinVar. | 1 | |
Natural variantiVAR_063734 | 84 | G → R in PNDM4; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121908274EnsemblClinVar. | 1 | |
Natural variantiVAR_063735 | 89 | R → C in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356669EnsemblClinVar. | 1 | |
Natural variantiVAR_003974 | 89 | R → H in HPRI; impairs post-translational cleavage. 2 PublicationsCorresponds to variant dbSNP:rs28933985EnsemblClinVar. | 1 | |
Natural variantiVAR_003975 | 89 | R → L in HPRI; Kyoto. 1 PublicationCorresponds to variant dbSNP:rs28933985EnsemblClinVar. | 1 | |
Natural variantiVAR_063736 | 90 | G → C in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356670EnsemblClinVar. | 1 | |
Natural variantiVAR_003976 | 92 | V → L in Wakayama. 1 PublicationCorresponds to variant dbSNP:rs121918102EnsemblClinVar. | 1 | |
Natural variantiVAR_063737 | 96 | C → S in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs80356671EnsemblClinVar. | 1 | |
Natural variantiVAR_063738 | 96 | C → Y in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356671EnsemblClinVar. | 1 | |
Natural variantiVAR_063739 | 101 | S → C in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs121908276EnsemblClinVar. | 1 | |
Natural variantiVAR_063740 | 103 | Y → C in PNDM4. 1 PublicationCorresponds to variant dbSNP:rs121908277EnsemblClinVar. | 1 | |
Natural variantiVAR_063741 | 108 | Y → C in PNDM4. 2 PublicationsCorresponds to variant dbSNP:rs80356672EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00565 Genomic DNA Translation: CAA23828.1 M10039 Genomic DNA Translation: AAA59173.1 J00265 Genomic DNA Translation: AAA59172.1 X70508 mRNA Translation: CAA49913.1 L15440 Genomic DNA Translation: AAA59179.1 Sequence problems. AY899304 mRNA Translation: AAW83741.1 AY138590 Genomic DNA Translation: AAN39451.1 BT006808 mRNA Translation: AAP35454.1 CH471158 Genomic DNA Translation: EAX02488.1 BC005255 mRNA Translation: AAH05255.1 AJ009655 Genomic DNA Translation: CAA08766.1 |
CCDSi | CCDS7729.1 [P01308-1] |
PIRi | A93222, IPHU |
RefSeqi | NP_000198.1, NM_000207.2 [P01308-1] NP_001172026.1, NM_001185097.1 [P01308-1] NP_001172027.1, NM_001185098.1 [P01308-1] NP_001278826.1, NM_001291897.1 [P01308-1] |
Genome annotation databases
Ensembli | ENST00000250971; ENSP00000250971; ENSG00000254647 [P01308-1] ENST00000381330; ENSP00000370731; ENSG00000254647 [P01308-1] ENST00000397262; ENSP00000380432; ENSG00000254647 [P01308-1] |
GeneIDi | 3630 |
KEGGi | hsa:3630 |
UCSCi | uc001lvn.3, human [P01308-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Insulin at Eli Lilly Clinical information on Eli Lilly insulin products |
Protein Spotlight Protein of the 20th century - Issue 9 of April 2001 |
Wikipedia Insulin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00565 Genomic DNA Translation: CAA23828.1 M10039 Genomic DNA Translation: AAA59173.1 J00265 Genomic DNA Translation: AAA59172.1 X70508 mRNA Translation: CAA49913.1 L15440 Genomic DNA Translation: AAA59179.1 Sequence problems. AY899304 mRNA Translation: AAW83741.1 AY138590 Genomic DNA Translation: AAN39451.1 BT006808 mRNA Translation: AAP35454.1 CH471158 Genomic DNA Translation: EAX02488.1 BC005255 mRNA Translation: AAH05255.1 AJ009655 Genomic DNA Translation: CAA08766.1 |
CCDSi | CCDS7729.1 [P01308-1] |
PIRi | A93222, IPHU |
RefSeqi | NP_000198.1, NM_000207.2 [P01308-1] NP_001172026.1, NM_001185097.1 [P01308-1] NP_001172027.1, NM_001185098.1 [P01308-1] NP_001278826.1, NM_001291897.1 [P01308-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A7F | NMR | - | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
1AI0 | NMR | - | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
1AIY | NMR | - | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
1B9E | X-ray | 2.50 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1BEN | X-ray | 1.40 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1EFE | NMR | - | A | 25-54 | [»] | |
A | 90-110 | [»] | ||||
1EV3 | X-ray | 1.78 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1EV6 | X-ray | 1.90 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
1EVR | X-ray | 1.90 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
1FU2 | X-ray | 3.24 | A/C/E/G | 90-110 | [»] | |
B/D/F/H | 25-54 | [»] | ||||
1FUB | X-ray | 3.09 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1G7A | X-ray | 1.20 | A/C/E/G | 90-110 | [»] | |
B/D/F/H | 25-54 | [»] | ||||
1G7B | X-ray | 1.30 | A/C/E/G | 90-110 | [»] | |
B/D/F/H | 25-54 | [»] | ||||
1GUJ | X-ray | 1.62 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1HIQ | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1HIS | NMR | - | A | 90-110 | [»] | |
B | 25-49 | [»] | ||||
1HIT | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1HLS | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1HTV | X-ray | 1.90 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-51 | [»] | ||||
1HUI | NMR | - | A | 90-110 | [»] | |
B | 26-53 | [»] | ||||
1IOG | NMR | - | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
1IOH | NMR | - | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
1J73 | X-ray | 2.00 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1JCA | X-ray | 2.50 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1JCO | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1JK8 | X-ray | 2.40 | C | 35-47 | [»] | |
1K3M | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1KMF | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1LKQ | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1LPH | X-ray | 2.30 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1MHI | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1MHJ | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1MSO | X-ray | 1.00 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1OS3 | X-ray | 1.95 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1OS4 | X-ray | 2.25 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
1Q4V | X-ray | 2.00 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1QIY | X-ray | 2.30 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
1QIZ | X-ray | 2.00 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
1QJ0 | X-ray | 2.40 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1RWE | X-ray | 1.80 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1SF1 | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1SJT | NMR | - | A | 90-110 | [»] | |
B | 25-51 | [»] | ||||
1SJU | NMR | - | A | 25-110 | [»] | |
1T0C | NMR | - | A | 57-87 | [»] | |
1T1K | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1T1P | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1T1Q | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1TRZ | X-ray | 1.60 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1TYL | X-ray | 1.90 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1TYM | X-ray | 1.90 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1UZ9 | X-ray | 1.60 | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
1VKT | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1W8P | X-ray | 2.08 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
1XDA | X-ray | 1.80 | A/C/E/G | 90-110 | [»] | |
B/D/F/H | 25-53 | [»] | ||||
1XGL | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
1XW7 | X-ray | 2.30 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1ZEG | X-ray | 1.60 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1ZEH | X-ray | 1.50 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
1ZNJ | X-ray | 2.00 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
2AIY | NMR | - | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
2C8Q | X-ray | 1.95 | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
2C8R | X-ray | 1.50 | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
2CEU | X-ray | 1.80 | A/C | 90-110 | [»] | |
B/D | 25-49 | [»] | ||||
2G54 | X-ray | 2.25 | C/D | 25-54 | [»] | |
2G56 | X-ray | 2.20 | C/D | 25-54 | [»] | |
2H67 | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2HH4 | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2HHO | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2HIU | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2JMN | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2JUM | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2JUU | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2JUV | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2JV1 | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2JZQ | NMR | - | A | 25-54 | [»] | |
A | 90-110 | [»] | ||||
2K91 | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2K9R | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2KJJ | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2KJU | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2KQP | NMR | - | A | 25-110 | [»] | |
2KQQ | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2KXK | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2L1Y | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2L1Z | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2LGB | NMR | - | A | 90-110 | [»] | |
B | 25-55 | [»] | ||||
2LWZ | NMR | - | A | 25-54 | [»] | |
A | 89-110 | [»] | ||||
2M1D | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2M1E | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2M2M | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2M2N | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2M2O | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2M2P | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2MLI | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2MPG | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2MPI | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2MVC | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2MVD | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2N2V | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2N2W | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2N2X | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2OLY | X-ray | 1.70 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
2OLZ | X-ray | 1.70 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
2OM0 | X-ray | 2.05 | 1/3/A/C/E/G/I/K/Q/S/U/X/a/c/e/g/i/k | 90-110 | [»] | |
2/4/B/D/F/H/J/L/R/T/V/Y/b/d/f/h/j/l | 25-54 | [»] | ||||
2OM1 | X-ray | 1.97 | 1/3/A/C/E/G/I/K/Q/S/U/X/a/c/e/g/i/k | 90-110 | [»] | |
2/4/B/D/F/H/J/L/R/T/V/Y/b/d/f/h/j/l | 25-54 | [»] | ||||
2OMG | X-ray | 1.52 | A/C/E | 90-110 | [»] | |
B/D/F | 25-54 | [»] | ||||
2OMH | X-ray | 1.36 | A/C/E | 90-110 | [»] | |
B/D/F | 25-54 | [»] | ||||
2OMI | X-ray | 2.24 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
2OMQ | X-ray | 2.00 | A/B/C/D | 36-41 | [»] | |
2QIU | X-ray | 2.00 | A/C | 89-110 | [»] | |
B/D | 25-54 | [»] | ||||
2R34 | X-ray | 2.25 | A/C | 89-110 | [»] | |
B/D | 25-54 | [»] | ||||
2R35 | X-ray | 2.08 | A/C | 89-110 | [»] | |
B/D | 25-54 | [»] | ||||
2R36 | X-ray | 2.00 | A/C | 89-110 | [»] | |
B/D | 25-54 | [»] | ||||
2RN5 | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2VJZ | X-ray | 1.80 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
2VK0 | X-ray | 2.20 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
2W44 | X-ray | 2.00 | A/C/E | 94-110 | [»] | |
B/D/F | 25-53 | [»] | ||||
2WBY | X-ray | 2.60 | C/E | 90-109 | [»] | |
D/F | 25-43 | [»] | ||||
2WC0 | X-ray | 2.80 | C/E | 90-110 | [»] | |
D/F | 25-54 | [»] | ||||
2WRU | X-ray | 1.57 | A | 90-110 | [»] | |
B | 25-50 | [»] | ||||
2WRV | X-ray | 2.15 | A | 90-110 | [»] | |
B | 25-50 | [»] | ||||
2WRW | X-ray | 2.41 | A | 90-110 | [»] | |
B | 25-50 | [»] | ||||
2WRX | X-ray | 1.50 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
2WS0 | X-ray | 2.10 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2WS1 | X-ray | 1.60 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
2WS4 | X-ray | 1.90 | A | 90-110 | [»] | |
B | 25-50 | [»] | ||||
2WS6 | X-ray | 1.50 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
2WS7 | X-ray | 2.59 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-50 | [»] | ||||
3AIY | NMR | - | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
3BXQ | X-ray | 1.30 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3E7Y | X-ray | 1.60 | A/C | 90-110 | [»] | |
B/D | 25-53 | [»] | ||||
3E7Z | X-ray | 1.70 | A/C | 90-110 | [»] | |
B/D | 25-53 | [»] | ||||
3EXX | X-ray | 1.35 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3FQ9 | X-ray | 1.35 | A/C | 91-110 | [»] | |
B/D | 25-54 | [»] | ||||
3HYD | X-ray | 1.00 | A | 35-41 | [»] | |
3I3Z | X-ray | 1.60 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
3I40 | X-ray | 1.85 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
3ILG | X-ray | 1.90 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3INC | X-ray | 1.85 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3IR0 | X-ray | 2.20 | A/C/E/G/I/K/M/O/R/T/V/X | 90-110 | [»] | |
B/D/F/H/J/L/N/P/S/U/W/Y | 25-54 | [»] | ||||
3JSD | X-ray | 2.50 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3KQ6 | X-ray | 1.90 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3P2X | X-ray | 2.00 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3P33 | X-ray | 2.30 | A/C/E/G | 90-110 | [»] | |
B/D/F/H | 25-54 | [»] | ||||
3Q6E | X-ray | 2.05 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3ROV | X-ray | 2.30 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
3TT8 | X-ray | 1.12 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3U4N | X-ray | 1.98 | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
3UTQ | X-ray | 1.67 | C | 15-24 | [»] | |
3UTS | X-ray | 2.71 | C/H | 15-24 | [»] | |
3UTT | X-ray | 2.60 | C/H | 15-24 | [»] | |
3V19 | X-ray | 2.00 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3V1G | X-ray | 2.20 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3W11 | X-ray | 3.90 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
3W12 | X-ray | 4.30 | A | 90-110 | [»] | |
B | 25-50 | [»] | ||||
3W13 | X-ray | 4.30 | A | 90-110 | [»] | |
B | 25-50 | [»] | ||||
3W7Y | X-ray | 0.92 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3W7Z | X-ray | 1.15 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
3W80 | X-ray | 1.40 | A/C/E/G | 90-110 | [»] | |
B/D/F/H | 25-54 | [»] | ||||
3ZI3 | X-ray | 1.70 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
3ZQR | X-ray | 1.90 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
3ZS2 | X-ray | 1.97 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
3ZU1 | X-ray | 1.60 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4AIY | NMR | - | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
4AJX | X-ray | 1.20 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-53 | [»] | ||||
4AJZ | X-ray | 1.80 | A/C | 90-110 | [»] | |
B/D | 25-53 | [»] | ||||
4AK0 | X-ray | 2.28 | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
4AKJ | X-ray | 2.01 | A/C | 90-110 | [»] | |
B/D | 25-53 | [»] | ||||
4CXL | X-ray | 1.50 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
4CXN | X-ray | 1.70 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
4CY7 | X-ray | 1.40 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EFX | X-ray | 1.98 | A/C | 90-110 | [»] | |
B/D | 25-52 | [»] | ||||
4EWW | X-ray | 2.30 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EWX | X-ray | 2.20 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EWZ | X-ray | 1.79 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EX0 | X-ray | 1.86 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EX1 | X-ray | 1.66 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EXX | X-ray | 1.55 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EY1 | X-ray | 1.47 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EY9 | X-ray | 1.47 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EYD | X-ray | 1.47 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EYN | X-ray | 1.53 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4EYP | X-ray | 1.59 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F0N | X-ray | 1.68 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F0O | X-ray | 1.67 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F1A | X-ray | 1.80 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F1B | X-ray | 1.59 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F1C | X-ray | 1.70 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F1D | X-ray | 1.64 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F1F | X-ray | 1.68 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F1G | X-ray | 1.64 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F4T | X-ray | 1.64 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F4V | X-ray | 1.64 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F51 | X-ray | 1.64 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4F8F | X-ray | 1.68 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4FG3 | X-ray | 2.00 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4FKA | X-ray | 1.08 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4GBC | X-ray | 1.78 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4GBI | X-ray | 2.50 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4GBK | X-ray | 2.40 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4GBL | X-ray | 2.50 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4GBN | X-ray | 1.87 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4IUZ | X-ray | 1.60 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
4IYD | X-ray | 1.66 | A | 90-109 | [»] | |
B | 25-53 | [»] | ||||
4IYF | X-ray | 1.80 | A | 90-109 | [»] | |
B | 25-53 | [»] | ||||
4NIB | X-ray | 1.40 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
4OGA | X-ray | 3.50 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
4P65 | X-ray | 1.50 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
4RXW | X-ray | 1.73 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4UNE | X-ray | 1.59 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4UNG | X-ray | 1.81 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4UNH | X-ray | 2.75 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
4WDI | X-ray | 2.31 | C/F | 39-47 | [»] | |
4XC4 | X-ray | 1.50 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
4Y19 | X-ray | 2.50 | C | 75-90 | [»] | |
4Y1A | X-ray | 4.00 | C | 75-90 | [»] | |
4Z76 | X-ray | 1.88 | C/F | 39-46 | [»] | |
4Z77 | X-ray | 1.85 | C/F | 39-47 | [»] | |
4Z78 | X-ray | 2.30 | C/F/I | 39-48 | [»] | |
5AIY | NMR | - | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
5BOQ | X-ray | 1.70 | A/C/E/G | 90-110 | [»] | |
B/D/F/H | 25-54 | [»] | ||||
5BPO | X-ray | 1.90 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5BQQ | X-ray | 1.54 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-50 | [»] | ||||
5BTS | X-ray | 1.77 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5C0D | X-ray | 1.68 | C | 15-24 | [»] | |
5CJO | X-ray | 3.29 | a | 90-109 | [»] | |
5CNY | X-ray | 1.70 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5CO2 | X-ray | 1.70 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5CO6 | X-ray | 1.80 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5CO9 | X-ray | 1.92 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5E7W | X-ray | 0.95 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5EMS | X-ray | 2.30 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-52 | [»] | ||||
5EN9 | X-ray | 1.50 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5ENA | X-ray | 1.35 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5HPR | X-ray | 1.33 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5HPU | X-ray | 2.20 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5HQI | X-ray | 0.97 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5HRQ | X-ray | 1.28 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
5HYJ | X-ray | 3.06 | C/H | 15-24 | [»] | |
5MAM | X-ray | 2.20 | 0/2/4/A/C/E/G/I/K/M/O/Q/S/U/W/Y | 90-110 | [»] | |
1/3/5/B/D/F/H/J/L/N/P/R/T/V/X/Z | 25-54 | [»] | ||||
5MHD | NMR | - | A | 90-110 | [»] | |
B | 25-55 | [»] | ||||
5MT3 | X-ray | 2.02 | A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e | 90-110 | [»] | |
B/D/F/H/J/L/N/P/R/T/V/X/Z/b/d/f | 25-54 | [»] | ||||
5MT9 | X-ray | 1.88 | A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e | 90-110 | [»] | |
B/D/F/H/J/L/N/P/R/T/V/X/Z/b/d/f | 25-54 | [»] | ||||
5MWQ | NMR | - | A | 90-110 | [»] | |
B | 25-56 | [»] | ||||
5T7R | X-ray | 1.55 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5UDP | X-ray | 1.35 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
5UOZ | X-ray | 1.17 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5UQA | X-ray | 1.31 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
5URT | X-ray | 1.18 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5URU | X-ray | 2.41 | A/C/E/G | 90-110 | [»] | |
B/D/F/H | 25-54 | [»] | ||||
5USP | X-ray | 1.17 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5USS | X-ray | 2.06 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5USV | X-ray | 1.30 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5UU2 | X-ray | 1.22 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
5UU3 | X-ray | 2.25 | A/C/E/G/I/K/M/O/Q/S/U/W | 90-110 | [»] | |
B/D/F/H/J/L/N/P/R/T/V/X | 25-54 | [»] | ||||
5UU4 | X-ray | 1.97 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
5VIZ | X-ray | 1.70 | A | 90-109 | [»] | |
B | 25-53 | [»] | ||||
5WBT | NMR | - | A | 25-54 | [»] | |
A | 90-110 | [»] | ||||
5WDM | X-ray | 2.80 | A/B/C/D/E/F | 25-110 | [»] | |
5WOB | X-ray | 3.95 | a/b/c/d/e/f/g/h | 90-109 | [»] | |
6B3Q | electron microscopy | 3.70 | a/b | 1-110 | [»] | |
6B70 | electron microscopy | 3.70 | a/c | 1-110 | [»] | |
6BFC | electron microscopy | 3.70 | a/b | 1-110 | [»] | |
6CE7 | electron microscopy | 7.40 | N | 90-110 | [»] | |
6CE9 | electron microscopy | 4.30 | K/N | 90-110 | [»] | |
6CEB | electron microscopy | 4.70 | K/N | 90-110 | [»] | |
6CK2 | X-ray | 2.25 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
6GNQ | X-ray | 2.20 | A/C/E/G/I/K/M/O/Q/S/U/W | 90-110 | [»] | |
B/D/F/H/J/L/N/P/R/T/V/X | 25-54 | [»] | ||||
6GV0 | X-ray | 1.26 | B/D | 25-54 | [»] | |
G/I | 90-110 | [»] | ||||
6H3M | X-ray | 1.82 | A/C/E/G/I/K/N/R | 90-110 | [»] | |
B/D/F/H/J/L/P/Q | 25-54 | [»] | ||||
6HN5 | electron microscopy | 3.20 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
6JK8 | electron microscopy | 4.70 | C/D | 1-110 | [»] | |
6JR3 | electron microscopy | 14.50 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
6K59 | NMR | - | A | 90-109 | [»] | |
B | 25-56 | [»] | ||||
6NWV | X-ray | 1.60 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
6O17 | X-ray | 1.58 | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
6P4Z | X-ray | 1.80 | A/C | 90-110 | [»] | |
B/D | 25-54 | [»] | ||||
6S34 | X-ray | 1.35 | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
6S4I | X-ray | 1.51 | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
6S4J | X-ray | 1.50 | A | 90-110 | [»] | |
B | 25-53 | [»] | ||||
6SOF | electron microscopy | 4.30 | E/G/I/K | 90-110 | [»] | |
F/H/J/L | 25-54 | [»] | ||||
6TYH | X-ray | 1.60 | A/C/E/G/I/K | 90-110 | [»] | |
B/D/F/H/J/L | 25-54 | [»] | ||||
6U46 | NMR | - | A | 25-109 | [»] | |
6VEP | X-ray | 2.90 | A/G/M/S | 90-110 | [»] | |
B/H/N/T | 25-54 | [»] | ||||
6VET | X-ray | 1.46 | A/C/E | 90-110 | [»] | |
B/D/F | 25-46 | [»] | ||||
6X4X | NMR | - | A | 90-110 | [»] | |
B | 25-54 | [»] | ||||
BMRBi | P01308 | |||||
PCDDBi | P01308 | |||||
SASBDBi | P01308 | |||||
SMRi | P01308 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109842, 24 interactors |
DIPi | DIP-6024N |
IntActi | P01308, 18 interactors |
MINTi | P01308 |
STRINGi | 9606.ENSP00000380432 |
Chemistry databases
ChEMBLi | CHEMBL5881 |
DrugBanki | DB01776, M-Cresol DB08231, Myristic acid DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Protein family/group databases
Allergomei | 2121, Hom s Insulin |
PTM databases
CarbonylDBi | P01308 |
iPTMneti | P01308 |
PhosphoSitePlusi | P01308 |
Genetic variation databases
BioMutai | INS |
DMDMi | 124617 |
Proteomic databases
EPDi | P01308 |
jPOSTi | P01308 |
MassIVEi | P01308 |
PaxDbi | P01308 |
PeptideAtlasi | P01308 |
PRIDEi | P01308 |
ProteomicsDBi | 51374 [P01308-1] |
Protocols and materials databases
ABCDi | P01308, 35 sequenced antibodies |
Antibodypediai | 56056, 3386 antibodies |
DNASUi | 3630 |
Genome annotation databases
Ensembli | ENST00000250971; ENSP00000250971; ENSG00000254647 [P01308-1] ENST00000381330; ENSP00000370731; ENSG00000254647 [P01308-1] ENST00000397262; ENSP00000380432; ENSG00000254647 [P01308-1] |
GeneIDi | 3630 |
KEGGi | hsa:3630 |
UCSCi | uc001lvn.3, human [P01308-1] |
Organism-specific databases
CTDi | 3630 |
DisGeNETi | 3630 |
GeneCardsi | INS |
GeneReviewsi | INS |
HGNCi | HGNC:6081, INS |
HPAi | ENSG00000254647, Tissue enriched (pancreas) |
MalaCardsi | INS |
MIMi | 125852, phenotype 176730, gene 613370, phenotype 616214, phenotype 618858, phenotype |
neXtProti | NX_P01308 |
OpenTargetsi | ENSG00000254647 |
Orphaneti | 552, MODY 99885, Permanent neonatal diabetes mellitus |
PharmGKBi | PA201 |
VEuPathDBi | HostDB:ENSG00000254647.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5P5, Eukaryota |
GeneTreei | ENSGT00390000015440 |
InParanoidi | P01308 |
OMAi | APPQHLC |
PhylomeDBi | P01308 |
TreeFami | TF332820 |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-16190 |
PathwayCommonsi | P01308 |
Reactomei | R-HSA-210745, Regulation of gene expression in beta cells R-HSA-264876, Insulin processing R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin R-HSA-422356, Regulation of insulin secretion R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-74713, IRS activation R-HSA-74749, Signal attenuation R-HSA-74751, Insulin receptor signalling cascade R-HSA-74752, Signaling by Insulin receptor R-HSA-77387, Insulin receptor recycling R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-977225, Amyloid fiber formation |
SignaLinki | P01308 |
SIGNORi | P01308 |
Miscellaneous databases
BioGRID-ORCSi | 3630, 369 hits in 865 CRISPR screens |
EvolutionaryTracei | P01308 |
GeneWikii | Insulin |
GenomeRNAii | 3630 |
Pharosi | P01308, Tbio |
PROi | PR:P01308 |
RNActi | P01308, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000254647, Expressed in type B pancreatic cell and 95 other tissues |
ExpressionAtlasi | P01308, baseline and differential |
Genevisiblei | P01308, HS |
Family and domain databases
CDDi | cd04367, IlGF_insulin_like, 1 hit |
InterProi | View protein in InterPro IPR004825, Insulin IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR022353, Insulin_CS IPR022352, Insulin_family |
PANTHERi | PTHR11454, PTHR11454, 1 hit |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
PRINTSi | PR00277, INSULIN PR00276, INSULINFAMLY |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INS_HUMAN | |
Accessioni | P01308Primary (citable) accession number: P01308 Secondary accession number(s): Q5EEX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 10, 2021 | |
This is version 259 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries