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Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

GO - Molecular functioni

  • calcium channel regulator activity Source: ProtInc
  • G-protein coupled receptor activity Source: ProtInc
  • G-protein coupled receptor binding Source: GO_Central
  • neuropeptide hormone activity Source: ProtInc
  • signaling receptor binding Source: ProtInc

GO - Biological processi

  • adult feeding behavior Source: HGNC
  • antibacterial humoral response Source: UniProtKB
  • antifungal humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • calcium ion transport Source: ProtInc
  • cell proliferation Source: ProtInc
  • central nervous system neuron development Source: DFLAT
  • cerebral cortex development Source: DFLAT
  • chemical synaptic transmission Source: ProtInc
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • feeding behavior Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • innate immune response Source: UniProtKB
  • neuron projection development Source: DFLAT
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of appetite Source: HGNC
  • regulation of appetite Source: GO_Central
  • regulation of blood pressure Source: Ensembl
  • response to yeast Source: UniProtKB

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP01303

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:NPY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122585.7
HGNCiHGNC:7955 NPY
MIMi162640 gene
neXtProtiNX_P01303

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4852
OpenTargetsiENSG00000122585
PharmGKBiPA255

Chemistry databases

DrugBankiDB02952 Alpha-Aminoisobutyric Acid
DB03380 L-Tyrosinamide

Polymorphism and mutation databases

BioMutaiNPY
DMDMi128117

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
PeptideiPRO_000002532129 – 64Neuropeptide YAdd BLAST36
PeptideiPRO_000002532268 – 97C-flanking peptide of NPYAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Tyrosine amide1 Publication1
Modified residuei83PhosphothreonineCombined sources1

Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei30 – 31Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP01303
PeptideAtlasiP01303
PRIDEiP01303
ProteomicsDBi51373

PTM databases

iPTMnetiP01303
PhosphoSitePlusiP01303

Miscellaneous databases

PMAP-CutDBiP01303

Expressioni

Tissue specificityi

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Gene expression databases

BgeeiENSG00000122585
CleanExiHS_NPY
ExpressionAtlasiP01303 baseline and differential
GenevisibleiP01303 HS

Organism-specific databases

HPAiCAB016733
CAB034368
HPA036636
HPA044572
HPA056798

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • neuropeptide hormone activity Source: ProtInc
  • signaling receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi110914, 7 interactors
IntActiP01303, 10 interactors
MINTiP01303
STRINGi9606.ENSP00000242152

Chemistry databases

BindingDBiP01303

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi41 – 44Combined sources4
Helixi53 – 63Combined sources11

3D structure databases

ProteinModelPortaliP01303
SMRiP01303
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01303

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC Eukaryota
ENOG41128I2 LUCA
GeneTreeiENSGT00390000010775
HOGENOMiHOG000252942
HOVERGENiHBG006485
InParanoidiP01303
KOiK05232
OMAiFEDPSMW
OrthoDBiEOG091G0ZRE
PhylomeDBiP01303
TreeFamiTF332778

Family and domain databases

CDDicd00126 PAH, 1 hit
InterProiView protein in InterPro
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS
PANTHERiPTHR10533 PTHR10533, 1 hit
PfamiView protein in Pfam
PF00159 Hormone_3, 1 hit
PRINTSiPR00278 PANCHORMONE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267 Pancreatic_hormone-like, 1 hit
SMARTiView protein in SMART
SM00309 PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGNKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS
60 70 80 90
ALRHYINLIT RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPAMW
Length:97
Mass (Da):10,851
Last modified:July 21, 1986 - v1
Checksum:i832CF124321718F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53R → G in AAA59945 (PubMed:2427515).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0145987L → P. Corresponds to variant dbSNP:rs16139EnsemblClinVar.1
Natural variantiVAR_01459922L → M. Corresponds to variant dbSNP:rs5571Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01911 mRNA Translation: AAA59944.1
M14298, M14296, M14297 Genomic DNA Translation: AAA59945.1
M15789 mRNA Translation: AAA59946.1
AC004485 Genomic DNA Translation: AAQ96843.1
BC029497 mRNA Translation: AAH29497.1
CCDSiCCDS5387.1
PIRiA25198 NYHUY
RefSeqiNP_000896.1, NM_000905.3
UniGeneiHs.1832

Genome annotation databases

EnsembliENST00000242152; ENSP00000242152; ENSG00000122585
ENST00000405982; ENSP00000385282; ENSG00000122585
ENST00000407573; ENSP00000384364; ENSG00000122585
GeneIDi4852
KEGGihsa:4852
UCSCiuc003sww.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNPY_HUMAN
AccessioniPrimary (citable) accession number: P01303
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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