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Entry version 192 (18 Sep 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01303

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPY
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7955 NPY

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
162640 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01303

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4852

Open Targets

More...
OpenTargetsi
ENSG00000122585

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA255

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02952 Alpha-Aminoisobutyric Acid
DB03380 L-tyrosinamide
DB00191 Phentermine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NPY

Domain mapping of disease mutations (DMDM)

More...
DMDMi
128117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 281 PublicationAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002532129 – 64Neuropeptide YAdd BLAST36
PeptideiPRO_000002532268 – 97C-flanking peptide of NPYAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64Tyrosine amide1 Publication1
Modified residuei83PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei30 – 31Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1287
CPTAC-1288
CPTAC-1289
CPTAC-1290
CPTAC-1291

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P01303

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01303

PeptideAtlas

More...
PeptideAtlasi
P01303

PRoteomics IDEntifications database

More...
PRIDEi
P01303

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51373

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01303

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01303

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01303

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122585 Expressed in 133 organ(s), highest expression level in prostate gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01303 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01303 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016733
CAB034368
HPA036636
HPA044572
HPA056798

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110914, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P01303, 10 interactors

Molecular INTeraction database

More...
MINTi
P01303

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384364

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P01303

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01303

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01303

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0KC Eukaryota
ENOG41128I2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156475

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252942

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01303

KEGG Orthology (KO)

More...
KOi
K05232

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEDPSMW

Database of Orthologous Groups

More...
OrthoDBi
1542445at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01303

TreeFam database of animal gene trees

More...
TreeFami
TF332778

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00126 PAH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10533 PTHR10533, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00159 Hormone_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00278 PANCHORMONE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00309 PAH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01303-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGNKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS
60 70 80 90
ALRHYINLIT RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPAMW
Length:97
Mass (Da):10,851
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i832CF124321718F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53R → G in AAA59945 (PubMed:2427515).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0145987L → P. Corresponds to variant dbSNP:rs16139EnsemblClinVar.1
Natural variantiVAR_01459922L → M. Corresponds to variant dbSNP:rs5571Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K01911 mRNA Translation: AAA59944.1
M14298, M14296, M14297 Genomic DNA Translation: AAA59945.1
M15789 mRNA Translation: AAA59946.1
AC004485 Genomic DNA Translation: AAQ96843.1
BC029497 mRNA Translation: AAH29497.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5387.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A25198 NYHUY

NCBI Reference Sequences

More...
RefSeqi
NP_000896.1, NM_000905.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000242152; ENSP00000242152; ENSG00000122585
ENST00000405982; ENSP00000385282; ENSG00000122585
ENST00000407573; ENSP00000384364; ENSG00000122585

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4852

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4852

UCSC genome browser

More...
UCSCi
uc003sww.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Neuropeptide Y entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01911 mRNA Translation: AAA59944.1
M14298, M14296, M14297 Genomic DNA Translation: AAA59945.1
M15789 mRNA Translation: AAA59946.1
AC004485 Genomic DNA Translation: AAQ96843.1
BC029497 mRNA Translation: AAH29497.1
CCDSiCCDS5387.1
PIRiA25198 NYHUY
RefSeqiNP_000896.1, NM_000905.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QFANMR-A52-64[»]
1RONNMR-A29-64[»]
SMRiP01303
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110914, 7 interactors
IntActiP01303, 10 interactors
MINTiP01303
STRINGi9606.ENSP00000384364

Chemistry databases

BindingDBiP01303
DrugBankiDB02952 Alpha-Aminoisobutyric Acid
DB03380 L-tyrosinamide
DB00191 Phentermine

PTM databases

iPTMnetiP01303
PhosphoSitePlusiP01303

Polymorphism and mutation databases

BioMutaiNPY
DMDMi128117

Proteomic databases

CPTACiCPTAC-1287
CPTAC-1288
CPTAC-1289
CPTAC-1290
CPTAC-1291
MassIVEiP01303
PaxDbiP01303
PeptideAtlasiP01303
PRIDEiP01303
ProteomicsDBi51373

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4852
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242152; ENSP00000242152; ENSG00000122585
ENST00000405982; ENSP00000385282; ENSG00000122585
ENST00000407573; ENSP00000384364; ENSG00000122585
GeneIDi4852
KEGGihsa:4852
UCSCiuc003sww.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4852
DisGeNETi4852

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NPY
HGNCiHGNC:7955 NPY
HPAiCAB016733
CAB034368
HPA036636
HPA044572
HPA056798
MIMi162640 gene
neXtProtiNX_P01303
OpenTargetsiENSG00000122585
PharmGKBiPA255

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0KC Eukaryota
ENOG41128I2 LUCA
GeneTreeiENSGT00940000156475
HOGENOMiHOG000252942
InParanoidiP01303
KOiK05232
OMAiFEDPSMW
OrthoDBi1542445at2759
PhylomeDBiP01303
TreeFamiTF332778

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
SIGNORiP01303

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NPY human
EvolutionaryTraceiP01303

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Neuropeptide_Y

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4852

Pharos

More...
Pharosi
P01303
PMAP-CutDBiP01303

Protein Ontology

More...
PROi
PR:P01303

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122585 Expressed in 133 organ(s), highest expression level in prostate gland
ExpressionAtlasiP01303 baseline and differential
GenevisibleiP01303 HS

Family and domain databases

CDDicd00126 PAH, 1 hit
InterProiView protein in InterPro
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS
PANTHERiPTHR10533 PTHR10533, 1 hit
PfamiView protein in Pfam
PF00159 Hormone_3, 1 hit
PRINTSiPR00278 PANCHORMONE
SMARTiView protein in SMART
SM00309 PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPY_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01303
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 18, 2019
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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