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Protein

Pancreatic prohormone

Gene

PPY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
The physiological role for the icosapeptide has not yet been elucidated.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP01298

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic prohormone
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
INN: Obinepitide
Cleaved into the following 2 chains:
Pancreatic hormone
Short name:
PH
Gene namesi
Name:PPY
Synonyms:PNP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108849.7
HGNCiHGNC:9327 PPY
MIMi167780 gene
neXtProtiNX_P01298

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity. Obinepitide is derived from pancreatic hormone by having Gln-63.

Organism-specific databases

DisGeNETi5539
OpenTargetsiENSG00000108849
PharmGKBiPA33690

Polymorphism and mutation databases

BioMutaiPPY

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
PeptideiPRO_000002536530 – 65Pancreatic hormoneAdd BLAST36
PeptideiPRO_000002536669 – 88Pancreatic icosapeptideAdd BLAST20
PropeptideiPRO_000002536789 – 957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01298
PeptideAtlasiP01298
PRIDEiP01298
ProteomicsDBi51372

PTM databases

SwissPalmiP01298

Expressioni

Gene expression databases

BgeeiENSG00000108849 Expressed in 46 organ(s), highest expression level in type B pancreatic cell
CleanExiHS_PPY
ExpressionAtlasiP01298 baseline and differential
GenevisibleiP01298 HS

Organism-specific databases

HPAiCAB016735
HPA032122

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111531, 2 interactors
IntActiP01298, 1 interactor
STRINGi9606.ENSP00000225992

Structurei

Secondary structure

195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01298
SMRiP01298
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01298

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7V9 Eukaryota
ENOG41115N2 LUCA
GeneTreeiENSGT00530000064295
HOGENOMiHOG000252942
InParanoidiP01298
KOiK05234
PhylomeDBiP01298
TreeFamiTF332778

Family and domain databases

CDDicd00126 PAH, 1 hit
InterProiView protein in InterPro
IPR015480 Pancreatic_hormone
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS
PANTHERiPTHR10533 PTHR10533, 1 hit
PTHR10533:SF2 PTHR10533:SF2, 1 hit
PfamiView protein in Pfam
PF00159 Hormone_3, 1 hit
PRINTSiPR00278 PANCHORMONE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267 Pancreatic_hormone-like, 1 hit
SMARTiView protein in SMART
SM00309 PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P01298-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAARLCLSL LLLSTCVALL LQPLLGAQGA PLEPVYPGDN ATPEQMAQYA
60 70 80 90
ADLRRYINML TRPRYGKRHK EDTLAFSEWG SPHAAVPREL SPLDL
Length:95
Mass (Da):10,445
Last modified:July 21, 1986 - v1
Checksum:i44F0265092F9C4A0
GO
Isoform 2 (identifier: P01298-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: R → RPRCVPQLGR...HSACPCCLFP

Note: No experimental confirmation available. Derived from EST data.Curated
Show »
Length:178
Mass (Da):18,786
Checksum:iF847D6246E7F608C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKP2K7EKP2_HUMAN
Pancreatic prohormone
PPY
105Annotation score:
K7EML0K7EML0_HUMAN
Pancreatic prohormone
PPY
79Annotation score:
A0A0U1RRD5A0A0U1RRD5_HUMAN
Pancreatic prohormone
PPY
132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86V → I in AAA60161 (PubMed:3753985).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05061578E → G. Corresponds to variant dbSNP:rs7215698Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05785262R → RPRCVPQLGREIPAPGTLGP LHIPGHTLSPAPAPAPSRPA LGKTGHLCSTGLDQCALGKM VPTGRYETGGLAPGHSACPC CLFP in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00491 mRNA Translation: CAA25161.1
M11726 Genomic DNA Translation: AAA60156.1
M15788 mRNA Translation: AAA60161.1
AC007993 Genomic DNA No translation available.
BC032225 mRNA Translation: AAH32225.1
BC040033 mRNA Translation: AAH40033.1
BP385720 mRNA No translation available.
CCDSiCCDS11472.1 [P01298-1]
PIRiA92498 PCHU
RefSeqiNP_002713.1, NM_002722.4 [P01298-1]
UniGeneiHs.558368
Hs.744427

Genome annotation databases

EnsembliENST00000225992; ENSP00000225992; ENSG00000108849 [P01298-1]
ENST00000591228; ENSP00000466009; ENSG00000108849 [P01298-1]
GeneIDi5539
KEGGihsa:5539
UCSCiuc002iep.4 human [P01298-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPAHO_HUMAN
AccessioniPrimary (citable) accession number: P01298
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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