GHRH

Functionⁱ

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

GO - Molecular functionⁱ

growth hormone-releasing hormone activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18329818
- 8421089
growth hormone-releasing hormone receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 1333056
- 7680413
neuropeptide hormone activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide hormone receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenohypophysis development Source: BHF-UCL
adenylate cyclase-activating G protein-coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 1333056
- 7680413
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 6192430
cellular response to calcium ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to interleukin-6
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
circadian sleep/wake cycle, non-REM sleep
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: Reactome
growth hormone secretion
Source: MGI
Inferred from direct assayⁱ
- 2857452
negative regulation of cardiac muscle cell apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 12867592
positive regulation of circadian sleep/wake cycle, non-REM sleep
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of circadian sleep/wake cycle, REM sleep
Source: BHF-UCL
Non-traceable author statementⁱ
- 18329818
positive regulation of cytosolic calcium ion concentration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of growth hormone secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 18329818
- 8421089
positive regulation of insulin-like growth factor receptor signaling pathway
Source: BHF-UCL
Non-traceable author statementⁱ
- 11773624
positive regulation of insulin secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of lactation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of multicellular organism growth
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 8421089
positive regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to dexamethasone
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to food Source: BHF-UCL
response to hypoxia
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to leptin
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418555 G alpha (s) signalling events R-HSA-420092 Glucagon-type ligand receptors

Reactomeⁱ

R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Somatoliberin Alternative name(s): Growth hormone-releasing factor Short name: GRF Growth hormone-releasing hormone Short name: GHRH Somatocrinin Somatorelin INN: Sermorelin
Gene namesⁱ	Name:GHRH Synonyms:GHRF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118702.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4265 GHRH
MIMⁱ	139190 gene
neXtProtⁱ	NX_P01286

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Biotechnological useⁱ

Can be used for targeted secretion inhibition. A construct with this protein's ligand domain inserted between the C.botulinum neurotoxin type D (BoNT/D, botD) light chain and translocation domains, when injected into rats, leads to decreased growth hormone production. The GHRH ligand domain binds to the GHRH receptor on somatotrophs where it is taken up into endosomes. There the translocation domain inserts into the membrane, releasing the light chain which cleaves synaptobrevin and inhibits growth hormone exocytosis (PubMed:24029240, PubMed:26324071).1 Publication1 Publication

Pharmaceutical useⁱ

Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of growth hormone deficiency.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2691
Open Targets More...OpenTargetsⁱ	ENSG00000118702
PharmGKBⁱ	PA28675

Polymorphism and mutation databases

BioMutaⁱ	GHRH
DMDMⁱ	134521

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST	20
PropeptideⁱPRO_0000011438	21 – 31	1 PublicationAdd BLAST	11
PeptideⁱPRO_0000011439	32 – 75	SomatoliberinAdd BLAST	44
PropeptideⁱPRO_0000011440	78 – 108	Add BLAST	31

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	75	Leucine amide1 Publication		1

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbⁱ	P01286
PRIDEⁱ	P01286
ProteomicsDBⁱ	51370 51371 [P01286-2]

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000118702 Expressed in 42 organ(s), highest expression level in right atrium auricular region
CleanExⁱ	HS_GHRH
Genevisibleⁱ	P01286 HS

Interactionⁱ

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108958, 3 interactors
IntActⁱ	P01286, 2 interactors
Molecular INTeraction database More...MINTⁱ	P01286
STRINGⁱ	9606.ENSP00000237527

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01286
SMRⁱ	P01286
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glucagon family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J1XI Eukaryota ENOG410ZCJQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008103
HOGENOMⁱ	HOG000115417
HOVERGENⁱ	HBG004478
InParanoidⁱ	P01286
KEGG Orthology (KO) More...KOⁱ	K05260
OMAⁱ	RQVDSVW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11MO
PhylomeDBⁱ	P01286
TreeFamⁱ	TF353187

Family and domain databases

InterProⁱ	View protein in InterPro IPR000532 Glucagon_GIP_secretin_VIP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00123 Hormone_2, 1 hit
SMARTⁱ	View protein in SMART SM00070 GLUCA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00260 GLUCAGON, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P01286-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLWVFFFVI LTLSNSSHCS PPPPLTLRMR RYADAIFTNS YRKVLGQLSA 
        60         70         80         90        100
RKLLQDIMSR QQGESNQERG ARARLGRQVD SMWAEQKQME LESILVALLQ 

KHSRNSQG

Length:108

Mass (Da):12,447

Last modified:July 21, 1986 - v1

Checksum:ⁱ366AE05383488C53

GO

Isoform 2 (identifier: P01286-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
103-103: Missing.

« Hide

        10         20         30         40         50
MPLWVFFFVI LTLSNSSHCS PPPPLTLRMR RYADAIFTNS YRKVLGQLSA 
        60         70         80         90        100
RKLLQDIMSR QQGESNQERG ARARLGRQVD SMWAEQKQME LESILVALLQ 

KHRNSQG

Show »

Length:107

Mass (Da):12,360

Checksum:ⁱ74432263093C5367

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	92	E → D in CAA24955 (PubMed:6415488).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049185	32	Y → C. Corresponds to variant dbSNP:rs17787698Ensembl.		1
Natural variantⁱVAR_024328	75	L → F. Corresponds to variant dbSNP:rs4988492Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_023146	103	Missing in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L29177 Genomic DNA No translation available. L00137 , L00134, L00135, L00136 Genomic DNA Translation: AAA52608.1 L00137 , L00134, L00135, L00136 Genomic DNA Translation: AAA52609.1 AL031659 Genomic DNA No translation available. BC098109 mRNA Translation: AAH98109.1 BC098161 mRNA Translation: AAH98161.1 BC099727 mRNA Translation: AAH99727.1 X00094 mRNA Translation: CAA24955.1 X00094 mRNA Translation: CAA24956.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13292.1 [P01286-1] CCDS54460.1 [P01286-2]
PIRⁱ	A21902 RHHUS
NCBI Reference Sequences More...RefSeqⁱ	NP_001171660.1, NM_001184731.2 [P01286-2] NP_066567.1, NM_021081.5 [P01286-1] XP_011527086.1, XM_011528784.2 [P01286-1] XP_011527090.1, XM_011528788.2 [P01286-2]
UniGeneⁱ	Hs.37023

Genome annotation databases

Ensemblⁱ	ENST00000237527; ENSP00000237527; ENSG00000118702 [P01286-1] ENST00000373611; ENSP00000362713; ENSG00000118702 [P01286-2] ENST00000373614; ENSP00000362716; ENSG00000118702 [P01286-1]
GeneIDⁱ	2691
KEGGⁱ	hsa:2691
UCSC genome browser More...UCSCⁱ	uc002xgr.5 human [P01286-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01286	GHRH isoform 1		PANTR		108	UniRef90_P01286
Uncharacterized protein		PANPA		108
GHRH isoform 1		PONAB		108
Uncharacterized protein		NOMLE		108
Uncharacterized protein		CERAT		108
+11

Protein	Similar proteins		Species	Score	Length	Source
P01286	Somatoliberin		RAT		104	UniRef50_P01286
Somatoliberin		BOVIN		106
Somatoliberin		SHEEP		44
Somatoliberin		CAPHI		44
Somatoliberin		MESAU		107
+132

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Growth hormone releasing hormone entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L29177 Genomic DNA No translation available. L00137 , L00134, L00135, L00136 Genomic DNA Translation: AAA52608.1 L00137 , L00134, L00135, L00136 Genomic DNA Translation: AAA52609.1 AL031659 Genomic DNA No translation available. BC098109 mRNA Translation: AAH98109.1 BC098161 mRNA Translation: AAH98161.1 BC099727 mRNA Translation: AAH99727.1 X00094 mRNA Translation: CAA24955.1 X00094 mRNA Translation: CAA24956.1
CCDSⁱ	CCDS13292.1 [P01286-1] CCDS54460.1 [P01286-2]
PIRⁱ	A21902 RHHUS
RefSeqⁱ	NP_001171660.1, NM_001184731.2 [P01286-2] NP_066567.1, NM_021081.5 [P01286-1] XP_011527086.1, XM_011528784.2 [P01286-1] XP_011527090.1, XM_011528788.2 [P01286-2]
UniGeneⁱ	Hs.37023

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5BQM	X-ray	3.10	B/D	34-73	[»]
ProteinModelPortalⁱ	P01286
SMRⁱ	P01286
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108958, 3 interactors
IntActⁱ	P01286, 2 interactors
MINTⁱ	P01286
STRINGⁱ	9606.ENSP00000237527

Polymorphism and mutation databases

BioMutaⁱ	GHRH
DMDMⁱ	134521

Proteomic databases

PaxDbⁱ	P01286
PRIDEⁱ	P01286
ProteomicsDBⁱ	51370 51371 [P01286-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000237527; ENSP00000237527; ENSG00000118702 [P01286-1] ENST00000373611; ENSP00000362713; ENSG00000118702 [P01286-2] ENST00000373614; ENSP00000362716; ENSG00000118702 [P01286-1]
GeneIDⁱ	2691
KEGGⁱ	hsa:2691
UCSCⁱ	uc002xgr.5 human [P01286-1]

Organism-specific databases

CTDⁱ	2691
DisGeNETⁱ	2691
EuPathDBⁱ	HostDB:ENSG00000118702.9
GeneCardsⁱ	GHRH
HGNCⁱ	HGNC:4265 GHRH
MIMⁱ	139190 gene
neXtProtⁱ	NX_P01286
OpenTargetsⁱ	ENSG00000118702
PharmGKBⁱ	PA28675
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J1XI Eukaryota ENOG410ZCJQ LUCA
GeneTreeⁱ	ENSGT00390000008103
HOGENOMⁱ	HOG000115417
HOVERGENⁱ	HBG004478
InParanoidⁱ	P01286
KOⁱ	K05260
OMAⁱ	RQVDSVW
OrthoDBⁱ	EOG091G11MO
PhylomeDBⁱ	P01286
TreeFamⁱ	TF353187

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418555 G alpha (s) signalling events R-HSA-420092 Glucagon-type ligand receptors

Reactomeⁱ

R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Miscellaneous databases

GenomeRNAiⁱ	2691
Protein Ontology More...PROⁱ	PR:P01286
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118702 Expressed in 42 organ(s), highest expression level in right atrium auricular region
CleanExⁱ	HS_GHRH
Genevisibleⁱ	P01286 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000532 Glucagon_GIP_secretin_VIP
Pfamⁱ	View protein in Pfam PF00123 Hormone_2, 1 hit
SMARTⁱ	View protein in SMART SM00070 GLUCA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00260 GLUCAGON, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SLIB_HUMAN
Accessionⁱ	P01286Primary (citable) accession number: P01286 Secondary accession number(s): Q4KN10, Q5JYR1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P01286 (SLIB_HUMAN)

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Somatoliberin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Biotechnological useⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ