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Protein

Somatoliberin

Gene

GHRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

GO - Molecular functioni

  • growth hormone-releasing hormone activity Source: BHF-UCL
  • growth hormone-releasing hormone receptor binding Source: BHF-UCL
  • neuropeptide hormone activity Source: GO_Central
  • peptide hormone receptor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Somatocrinin
Somatorelin
INN: Sermorelin
Gene namesi
Name:GHRH
Synonyms:GHRF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000118702.9
HGNCiHGNC:4265 GHRH
MIMi139190 gene
neXtProtiNX_P01286

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Biotechnological usei

Can be used for targeted secretion inhibition. A construct with this protein's ligand domain inserted between the C.botulinum neurotoxin type D (BoNT/D, botD) light chain and translocation domains, when injected into rats, leads to decreased growth hormone production. The GHRH ligand domain binds to the GHRH receptor on somatotrophs where it is taken up into endosomes. There the translocation domain inserts into the membrane, releasing the light chain which cleaves synaptobrevin and inhibits growth hormone exocytosis (PubMed:24029240, PubMed:26324071).1 Publication1 Publication

Pharmaceutical usei

Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of growth hormone deficiency.

Organism-specific databases

DisGeNETi2691
OpenTargetsiENSG00000118702
PharmGKBiPA28675

Polymorphism and mutation databases

BioMutaiGHRH
DMDMi134521

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000001143821 – 311 PublicationAdd BLAST11
PeptideiPRO_000001143932 – 75SomatoliberinAdd BLAST44
PropeptideiPRO_000001144078 – 108Add BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01286
PRIDEiP01286
ProteomicsDBi51370
51371 [P01286-2]

Expressioni

Gene expression databases

BgeeiENSG00000118702 Expressed in 42 organ(s), highest expression level in right atrium auricular region
CleanExiHS_GHRH
GenevisibleiP01286 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108958, 3 interactors
IntActiP01286, 2 interactors
MINTiP01286
STRINGi9606.ENSP00000237527

Structurei

3D structure databases

ProteinModelPortaliP01286
SMRiP01286
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XI Eukaryota
ENOG410ZCJQ LUCA
GeneTreeiENSGT00390000008103
HOGENOMiHOG000115417
HOVERGENiHBG004478
InParanoidiP01286
KOiK05260
OMAiRQVDSVW
OrthoDBiEOG091G11MO
PhylomeDBiP01286
TreeFamiTF353187

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P01286-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLWVFFFVI LTLSNSSHCS PPPPLTLRMR RYADAIFTNS YRKVLGQLSA
60 70 80 90 100
RKLLQDIMSR QQGESNQERG ARARLGRQVD SMWAEQKQME LESILVALLQ

KHSRNSQG
Length:108
Mass (Da):12,447
Last modified:July 21, 1986 - v1
Checksum:i366AE05383488C53
GO
Isoform 2 (identifier: P01286-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-103: Missing.

Show »
Length:107
Mass (Da):12,360
Checksum:i74432263093C5367
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92E → D in CAA24955 (PubMed:6415488).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04918532Y → C. Corresponds to variant dbSNP:rs17787698Ensembl.1
Natural variantiVAR_02432875L → F. Corresponds to variant dbSNP:rs4988492Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023146103Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29177 Genomic DNA No translation available.
L00137
, L00134, L00135, L00136 Genomic DNA Translation: AAA52608.1
L00137
, L00134, L00135, L00136 Genomic DNA Translation: AAA52609.1
AL031659 Genomic DNA No translation available.
BC098109 mRNA Translation: AAH98109.1
BC098161 mRNA Translation: AAH98161.1
BC099727 mRNA Translation: AAH99727.1
X00094 mRNA Translation: CAA24955.1
X00094 mRNA Translation: CAA24956.1
CCDSiCCDS13292.1 [P01286-1]
CCDS54460.1 [P01286-2]
PIRiA21902 RHHUS
RefSeqiNP_001171660.1, NM_001184731.2 [P01286-2]
NP_066567.1, NM_021081.5 [P01286-1]
XP_011527086.1, XM_011528784.2 [P01286-1]
XP_011527090.1, XM_011528788.2 [P01286-2]
UniGeneiHs.37023

Genome annotation databases

EnsembliENST00000237527; ENSP00000237527; ENSG00000118702 [P01286-1]
ENST00000373611; ENSP00000362713; ENSG00000118702 [P01286-2]
ENST00000373614; ENSP00000362716; ENSG00000118702 [P01286-1]
GeneIDi2691
KEGGihsa:2691
UCSCiuc002xgr.5 human [P01286-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Growth hormone releasing hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29177 Genomic DNA No translation available.
L00137
, L00134, L00135, L00136 Genomic DNA Translation: AAA52608.1
L00137
, L00134, L00135, L00136 Genomic DNA Translation: AAA52609.1
AL031659 Genomic DNA No translation available.
BC098109 mRNA Translation: AAH98109.1
BC098161 mRNA Translation: AAH98161.1
BC099727 mRNA Translation: AAH99727.1
X00094 mRNA Translation: CAA24955.1
X00094 mRNA Translation: CAA24956.1
CCDSiCCDS13292.1 [P01286-1]
CCDS54460.1 [P01286-2]
PIRiA21902 RHHUS
RefSeqiNP_001171660.1, NM_001184731.2 [P01286-2]
NP_066567.1, NM_021081.5 [P01286-1]
XP_011527086.1, XM_011528784.2 [P01286-1]
XP_011527090.1, XM_011528788.2 [P01286-2]
UniGeneiHs.37023

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BQMX-ray3.10B/D34-73[»]
ProteinModelPortaliP01286
SMRiP01286
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108958, 3 interactors
IntActiP01286, 2 interactors
MINTiP01286
STRINGi9606.ENSP00000237527

Polymorphism and mutation databases

BioMutaiGHRH
DMDMi134521

Proteomic databases

PaxDbiP01286
PRIDEiP01286
ProteomicsDBi51370
51371 [P01286-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237527; ENSP00000237527; ENSG00000118702 [P01286-1]
ENST00000373611; ENSP00000362713; ENSG00000118702 [P01286-2]
ENST00000373614; ENSP00000362716; ENSG00000118702 [P01286-1]
GeneIDi2691
KEGGihsa:2691
UCSCiuc002xgr.5 human [P01286-1]

Organism-specific databases

CTDi2691
DisGeNETi2691
EuPathDBiHostDB:ENSG00000118702.9
GeneCardsiGHRH
HGNCiHGNC:4265 GHRH
MIMi139190 gene
neXtProtiNX_P01286
OpenTargetsiENSG00000118702
PharmGKBiPA28675
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1XI Eukaryota
ENOG410ZCJQ LUCA
GeneTreeiENSGT00390000008103
HOGENOMiHOG000115417
HOVERGENiHBG004478
InParanoidiP01286
KOiK05260
OMAiRQVDSVW
OrthoDBiEOG091G11MO
PhylomeDBiP01286
TreeFamiTF353187

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Miscellaneous databases

GenomeRNAii2691
PROiPR:P01286
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118702 Expressed in 42 organ(s), highest expression level in right atrium auricular region
CleanExiHS_GHRH
GenevisibleiP01286 HS

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLIB_HUMAN
AccessioniPrimary (citable) accession number: P01286
Secondary accession number(s): Q4KN10, Q5JYR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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