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UniProtKB - P01286 (SLIB_HUMAN)
Protein
Somatoliberin
Gene
GHRH
Organism
Homo sapiens (Human)
Status
Functioni
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
GO - Molecular functioni
- growth hormone-releasing hormone activity Source: BHF-UCL
- growth hormone-releasing hormone receptor binding Source: BHF-UCL
- neuropeptide hormone activity Source: GO_Central
- peptide hormone receptor binding Source: GO_Central
GO - Biological processi
- adenohypophysis development Source: BHF-UCL
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- cell-cell signaling Source: ProtInc
- growth hormone secretion Source: MGI
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of circadian sleep/wake cycle, REM sleep Source: BHF-UCL
- positive regulation of growth hormone secretion Source: BHF-UCL
- positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of multicellular organism growth Source: BHF-UCL
- response to food Source: BHF-UCL
Enzyme and pathway databases
PathwayCommonsi | P01286 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P01286 |
Names & Taxonomyi
Protein namesi | Recommended name: SomatoliberinAlternative name(s): Growth hormone-releasing factor Short name: GRF Growth hormone-releasing hormone Short name: GHRH Somatocrinin Somatorelin INN: Sermorelin |
Gene namesi | Name:GHRH Synonyms:GHRF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4265, GHRH |
MIMi | 139190, gene |
neXtProti | NX_P01286 |
VEuPathDBi | HostDB:ENSG00000118702 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Other locations
- perikaryon Source: GO_Central
- terminal bouton Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Biotechnological usei
Can be used for targeted secretion inhibition. A construct with this protein's ligand domain inserted between the C.botulinum neurotoxin type D (BoNT/D, botD) light chain and translocation domains, when injected into rats, leads to decreased growth hormone production. The GHRH ligand domain binds to the GHRH receptor on somatotrophs where it is taken up into endosomes. There the translocation domain inserts into the membrane, releasing the light chain which cleaves synaptobrevin and inhibits growth hormone exocytosis (PubMed:24029240, PubMed:26324071).1 Publication1 Publication
Pharmaceutical usei
Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of growth hormone deficiency.
Organism-specific databases
DisGeNETi | 2691 |
OpenTargetsi | ENSG00000118702 |
PharmGKBi | PA28675 |
Miscellaneous databases
Pharosi | P01286, Tbio |
Genetic variation databases
BioMutai | GHRH |
DMDMi | 134521 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000011438 | 21 – 31 | 1 PublicationAdd BLAST | 11 | |
PeptideiPRO_0000011439 | 32 – 75 | SomatoliberinAdd BLAST | 44 | |
PropeptideiPRO_0000011440 | 78 – 108 | Add BLAST | 31 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 75 | Leucine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residuesProteomic databases
PaxDbi | P01286 |
PeptideAtlasi | P01286 |
PRIDEi | P01286 |
Expressioni
Gene expression databases
Bgeei | ENSG00000118702, Expressed in right atrium auricular region and 65 other tissues |
Genevisiblei | P01286, HS |
Organism-specific databases
HPAi | ENSG00000118702, Tissue enriched (brain) |
Interactioni
GO - Molecular functioni
- growth hormone-releasing hormone activity Source: BHF-UCL
- growth hormone-releasing hormone receptor binding Source: BHF-UCL
- neuropeptide hormone activity Source: GO_Central
- peptide hormone receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108958, 2 interactors |
IntActi | P01286, 2 interactors |
MINTi | P01286 |
STRINGi | 9606.ENSP00000362716 |
Miscellaneous databases
RNActi | P01286, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P01286 |
SMRi | P01286 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the glucagon family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S2N6, Eukaryota |
GeneTreei | ENSGT00950000183154 |
HOGENOMi | CLU_174932_0_0_1 |
InParanoidi | P01286 |
OMAi | RMQRYAD |
OrthoDBi | 1445692at2759 |
PhylomeDBi | P01286 |
TreeFami | TF353187 |
Family and domain databases
InterProi | View protein in InterPro IPR015550, Glucagon IPR000532, Glucagon_GIP_secretin_VIP |
PANTHERi | PTHR11213, PTHR11213, 1 hit |
Pfami | View protein in Pfam PF00123, Hormone_2, 1 hit |
SMARTi | View protein in SMART SM00070, GLUCA, 1 hit |
PROSITEi | View protein in PROSITE PS00260, GLUCAGON, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P01286-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLWVFFFVI LTLSNSSHCS PPPPLTLRMR RYADAIFTNS YRKVLGQLSA
60 70 80 90 100
RKLLQDIMSR QQGESNQERG ARARLGRQVD SMWAEQKQME LESILVALLQ
KHSRNSQG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | E → D in CAA24955 (PubMed:6415488).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049185 | 32 | Y → C. Corresponds to variant dbSNP:rs17787698Ensembl. | 1 | |
Natural variantiVAR_024328 | 75 | L → F. Corresponds to variant dbSNP:rs4988492Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023146 | 103 | Missing in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29177 Genomic DNA No translation available. L00137 , L00134, L00135, L00136 Genomic DNA Translation: AAA52608.1 L00137 , L00134, L00135, L00136 Genomic DNA Translation: AAA52609.1 AL031659 Genomic DNA No translation available. BC098109 mRNA Translation: AAH98109.1 BC098161 mRNA Translation: AAH98161.1 BC099727 mRNA Translation: AAH99727.1 X00094 mRNA Translation: CAA24955.1 X00094 mRNA Translation: CAA24956.1 |
CCDSi | CCDS13292.1 [P01286-1] CCDS54460.1 [P01286-2] |
PIRi | A21902, RHHUS |
RefSeqi | NP_001171660.1, NM_001184731.2 [P01286-2] NP_066567.1, NM_021081.5 [P01286-1] XP_011527086.1, XM_011528784.2 [P01286-1] XP_011527090.1, XM_011528788.2 [P01286-2] |
Genome annotation databases
Ensembli | ENST00000237527; ENSP00000237527; ENSG00000118702 ENST00000373611; ENSP00000362713; ENSG00000118702 [P01286-2] ENST00000373614; ENSP00000362716; ENSG00000118702 |
GeneIDi | 2691 |
KEGGi | hsa:2691 |
MANE-Selecti | ENST00000373614.7; ENSP00000362716.2; NM_021081.6; NP_066567.1 |
UCSCi | uc002xgr.5, human [P01286-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Growth hormone releasing hormone entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29177 Genomic DNA No translation available. L00137 , L00134, L00135, L00136 Genomic DNA Translation: AAA52608.1 L00137 , L00134, L00135, L00136 Genomic DNA Translation: AAA52609.1 AL031659 Genomic DNA No translation available. BC098109 mRNA Translation: AAH98109.1 BC098161 mRNA Translation: AAH98161.1 BC099727 mRNA Translation: AAH99727.1 X00094 mRNA Translation: CAA24955.1 X00094 mRNA Translation: CAA24956.1 |
CCDSi | CCDS13292.1 [P01286-1] CCDS54460.1 [P01286-2] |
PIRi | A21902, RHHUS |
RefSeqi | NP_001171660.1, NM_001184731.2 [P01286-2] NP_066567.1, NM_021081.5 [P01286-1] XP_011527086.1, XM_011528784.2 [P01286-1] XP_011527090.1, XM_011528788.2 [P01286-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5BQM | X-ray | 3.10 | B/D | 34-73 | [»] | |
7CZ5 | electron microscopy | 2.60 | P | 32-75 | [»] | |
7V9M | electron microscopy | 3.29 | P | 32-75 | [»] | |
BMRBi | P01286 | |||||
SMRi | P01286 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108958, 2 interactors |
IntActi | P01286, 2 interactors |
MINTi | P01286 |
STRINGi | 9606.ENSP00000362716 |
Genetic variation databases
BioMutai | GHRH |
DMDMi | 134521 |
Proteomic databases
PaxDbi | P01286 |
PeptideAtlasi | P01286 |
PRIDEi | P01286 |
Protocols and materials databases
Antibodypediai | 11938, 288 antibodies from 25 providers |
DNASUi | 2691 |
Genome annotation databases
Ensembli | ENST00000237527; ENSP00000237527; ENSG00000118702 ENST00000373611; ENSP00000362713; ENSG00000118702 [P01286-2] ENST00000373614; ENSP00000362716; ENSG00000118702 |
GeneIDi | 2691 |
KEGGi | hsa:2691 |
MANE-Selecti | ENST00000373614.7; ENSP00000362716.2; NM_021081.6; NP_066567.1 |
UCSCi | uc002xgr.5, human [P01286-1] |
Organism-specific databases
CTDi | 2691 |
DisGeNETi | 2691 |
GeneCardsi | GHRH |
HGNCi | HGNC:4265, GHRH |
HPAi | ENSG00000118702, Tissue enriched (brain) |
MIMi | 139190, gene |
neXtProti | NX_P01286 |
OpenTargetsi | ENSG00000118702 |
PharmGKBi | PA28675 |
VEuPathDBi | HostDB:ENSG00000118702 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2N6, Eukaryota |
GeneTreei | ENSGT00950000183154 |
HOGENOMi | CLU_174932_0_0_1 |
InParanoidi | P01286 |
OMAi | RMQRYAD |
OrthoDBi | 1445692at2759 |
PhylomeDBi | P01286 |
TreeFami | TF353187 |
Enzyme and pathway databases
PathwayCommonsi | P01286 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P01286 |
Miscellaneous databases
BioGRID-ORCSi | 2691, 5 hits in 1036 CRISPR screens |
GenomeRNAii | 2691 |
Pharosi | P01286, Tbio |
PROi | PR:P01286 |
RNActi | P01286, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118702, Expressed in right atrium auricular region and 65 other tissues |
Genevisiblei | P01286, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015550, Glucagon IPR000532, Glucagon_GIP_secretin_VIP |
PANTHERi | PTHR11213, PTHR11213, 1 hit |
Pfami | View protein in Pfam PF00123, Hormone_2, 1 hit |
SMARTi | View protein in SMART SM00070, GLUCA, 1 hit |
PROSITEi | View protein in PROSITE PS00260, GLUCAGON, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SLIB_HUMAN | |
Accessioni | P01286Primary (citable) accession number: P01286 Secondary accession number(s): Q4KN10, Q5JYR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families