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UniProtKB - P01286 (SLIB_HUMAN)

Entry version 187 (23 Feb 2022)
Sequence version 1 (21 Jul 1986)
Previous versions | rss
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Protein

Somatoliberin

Gene

GHRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01286

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418555, G alpha (s) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P01286

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Somatocrinin
Somatorelin
INN: Sermorelin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GHRH
Synonyms:GHRF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4265, GHRH

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		139190, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01286

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000118702

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Can be used for targeted secretion inhibition. A construct with this protein's ligand domain inserted between the C.botulinum neurotoxin type D (BoNT/D, botD) light chain and translocation domains, when injected into rats, leads to decreased growth hormone production. The GHRH ligand domain binds to the GHRH receptor on somatotrophs where it is taken up into endosomes. There the translocation domain inserts into the membrane, releasing the light chain which cleaves synaptobrevin and inhibits growth hormone exocytosis (PubMed:24029240, PubMed:26324071).1 Publication1 Publication

<p>This subsection of the 'Pathology and Biotech' section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of growth hormone deficiency.

Organism-specific databases

DisGeNET

More...DisGeNETi		2691

Open Targets

More...OpenTargetsi		ENSG00000118702

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28675

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01286, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GHRH

Domain mapping of disease mutations (DMDM)

More...DMDMi		134521

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001143821 – 311 PublicationAdd BLAST11
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001143932 – 75SomatoliberinAdd BLAST44
PropeptideiPRO_000001144078 – 108Add BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01286

PeptideAtlas

More...PeptideAtlasi		P01286

PRoteomics IDEntifications database

More...PRIDEi		P01286

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118702, Expressed in right atrium auricular region and 65 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01286, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118702, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108958, 2 interactors

Protein interaction database and analysis system

More...IntActi		P01286, 2 interactors

Molecular INTeraction database

More...MINTi		P01286

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362716

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01286, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P01286

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01286

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S2N6, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183154

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_174932_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01286

Identification of Orthologs from Complete Genome Data

More...OMAi		RMQRYAD

Database of Orthologous Groups

More...OrthoDBi		1445692at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01286

TreeFam database of animal gene trees

More...TreeFami		TF353187

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015550, Glucagon
IPR000532, Glucagon_GIP_secretin_VIP

The PANTHER Classification System

More...PANTHERi		PTHR11213, PTHR11213, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00123, Hormone_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00070, GLUCA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00260, GLUCAGON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P01286-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLWVFFFVI LTLSNSSHCS PPPPLTLRMR RYADAIFTNS YRKVLGQLSA 
        60         70         80         90        100
RKLLQDIMSR QQGESNQERG ARARLGRQVD SMWAEQKQME LESILVALLQ 

KHSRNSQG
Length:108
Mass (Da):12,447
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i366AE05383488C53
GO
Isoform 2 (identifier: P01286-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-103: Missing.

Show »
Length:107
Mass (Da):12,360
Checksum:i74432263093C5367
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92E → D in CAA24955 (PubMed:6415488).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04918532Y → C. Corresponds to variant dbSNP:rs17787698Ensembl.1
Natural variantiVAR_02432875L → F. Corresponds to variant dbSNP:rs4988492Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023146103Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L29177 Genomic DNA No translation available.
L00137 L00136 Genomic DNA Translation: AAA52608.1
L00137 L00136 Genomic DNA Translation: AAA52609.1
AL031659 Genomic DNA No translation available.
BC098109 mRNA Translation: AAH98109.1
BC098161 mRNA Translation: AAH98161.1
BC099727 mRNA Translation: AAH99727.1
X00094 mRNA Translation: CAA24955.1
X00094 mRNA Translation: CAA24956.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13292.1 [P01286-1]
CCDS54460.1 [P01286-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A21902, RHHUS

NCBI Reference Sequences

More...RefSeqi		NP_001171660.1, NM_001184731.2 [P01286-2]
NP_066567.1, NM_021081.5 [P01286-1]
XP_011527086.1, XM_011528784.2 [P01286-1]
XP_011527090.1, XM_011528788.2 [P01286-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000237527; ENSP00000237527; ENSG00000118702
ENST00000373611; ENSP00000362713; ENSG00000118702 [P01286-2]
ENST00000373614; ENSP00000362716; ENSG00000118702

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2691

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2691

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000373614.7; ENSP00000362716.2; NM_021081.6; NP_066567.1

UCSC genome browser

More...UCSCi		uc002xgr.5, human [P01286-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Growth hormone releasing hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29177 Genomic DNA No translation available.
L00137 L00136 Genomic DNA Translation: AAA52608.1
L00137 L00136 Genomic DNA Translation: AAA52609.1
AL031659 Genomic DNA No translation available.
BC098109 mRNA Translation: AAH98109.1
BC098161 mRNA Translation: AAH98161.1
BC099727 mRNA Translation: AAH99727.1
X00094 mRNA Translation: CAA24955.1
X00094 mRNA Translation: CAA24956.1
CCDSiCCDS13292.1 [P01286-1]
CCDS54460.1 [P01286-2]
PIRiA21902, RHHUS
RefSeqiNP_001171660.1, NM_001184731.2 [P01286-2]
NP_066567.1, NM_021081.5 [P01286-1]
XP_011527086.1, XM_011528784.2 [P01286-1]
XP_011527090.1, XM_011528788.2 [P01286-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BQMX-ray3.10B/D34-73[»]
7CZ5electron microscopy2.60P32-75[»]
7V9Melectron microscopy3.29P32-75[»]
BMRBiP01286
SMRiP01286
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108958, 2 interactors
IntActiP01286, 2 interactors
MINTiP01286
STRINGi9606.ENSP00000362716

Genetic variation databases

BioMutaiGHRH
DMDMi134521

Proteomic databases

PaxDbiP01286
PeptideAtlasiP01286
PRIDEiP01286

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11938, 288 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		2691

Genome annotation databases

EnsembliENST00000237527; ENSP00000237527; ENSG00000118702
ENST00000373611; ENSP00000362713; ENSG00000118702 [P01286-2]
ENST00000373614; ENSP00000362716; ENSG00000118702
GeneIDi2691
KEGGihsa:2691
MANE-SelectiENST00000373614.7; ENSP00000362716.2; NM_021081.6; NP_066567.1
UCSCiuc002xgr.5, human [P01286-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2691
DisGeNETi2691

GeneCards: human genes, protein and diseases

More...GeneCardsi		GHRH
HGNCiHGNC:4265, GHRH
HPAiENSG00000118702, Tissue enriched (brain)
MIMi139190, gene
neXtProtiNX_P01286
OpenTargetsiENSG00000118702
PharmGKBiPA28675
VEuPathDBiHostDB:ENSG00000118702

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S2N6, Eukaryota
GeneTreeiENSGT00950000183154
HOGENOMiCLU_174932_0_0_1
InParanoidiP01286
OMAiRMQRYAD
OrthoDBi1445692at2759
PhylomeDBiP01286
TreeFamiTF353187

Enzyme and pathway databases

PathwayCommonsiP01286
ReactomeiR-HSA-418555, G alpha (s) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
SignaLinkiP01286

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2691, 5 hits in 1036 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2691
PharosiP01286, Tbio

Protein Ontology

More...PROi		PR:P01286
RNActiP01286, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118702, Expressed in right atrium auricular region and 65 other tissues
GenevisibleiP01286, HS

Family and domain databases

InterProiView protein in InterPro
IPR015550, Glucagon
IPR000532, Glucagon_GIP_secretin_VIP
PANTHERiPTHR11213, PTHR11213, 1 hit
PfamiView protein in Pfam
PF00123, Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070, GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260, GLUCAGON, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01286
Secondary accession number(s): Q4KN10, Q5JYR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 23, 2022
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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