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UniProtKB - P01282 (VIP_HUMAN)

Entry version 205 (23 Feb 2022)
Sequence version 1 (21 Jul 1986)
Previous versions | rss
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Protein

VIP peptides

Gene

VIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

1 Publication

PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01282

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418555, G alpha (s) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P01282

SIGNOR Signaling Network Open Resource

More...SIGNORi		P01282

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 3 chains:
Intestinal peptide PHV-42
Alternative name(s):
Peptide histidine valine 42
Intestinal peptide PHM-27
Alternative name(s):
Peptide histidine methioninamide 27
Vasoactive intestinal peptide
Short name:
VIP
Alternative name(s):
Vasoactive intestinal polypeptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12693, VIP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		192320, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01282

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000146469

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7432

Open Targets

More...OpenTargetsi		ENSG00000146469

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37312

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01282, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5737

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VIP

Domain mapping of disease mutations (DMDM)

More...DMDMi		138574

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001145721 – 79Add BLAST59
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001145881 – 122Intestinal peptide PHV-42Add BLAST42
PeptideiPRO_000001145981 – 107Intestinal peptide PHM-27Add BLAST27
PeptideiPRO_0000011460125 – 152Vasoactive intestinal peptideAdd BLAST28
PropeptideiPRO_0000011461156 – 170Add BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei76PhosphoserineBy similarity1
Modified residuei107Methionine amide1 Publication1
Modified residuei152Asparagine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01282

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01282

PeptideAtlas

More...PeptideAtlasi		P01282

PRoteomics IDEntifications database

More...PRIDEi		P01282

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51368 [P01282-1]
51369 [P01282-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01282

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01282

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000146469, Expressed in vermiform appendix and 141 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P01282, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01282, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000146469, Tissue enhanced (intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113273, 16 interactors

Protein interaction database and analysis system

More...IntActi		P01282, 14 interactors

Molecular INTeraction database

More...MINTi		P01282

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356213

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P01282

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01282, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P01282

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01282

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P01282

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVTA, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183154

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_133877_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01282

Identification of Orthologs from Complete Genome Data

More...OMAi		VSRNTRH

Database of Orthologous Groups

More...OrthoDBi		1343108at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01282

TreeFam database of animal gene trees

More...TreeFami		TF332804

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015550, Glucagon
IPR000532, Glucagon_GIP_secretin_VIP
IPR015523, VIP

The PANTHER Classification System

More...PANTHERi		PTHR11213, PTHR11213, 1 hit
PTHR11213:SF5, PTHR11213:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00123, Hormone_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00070, GLUCA, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00260, GLUCAGON, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P01282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTRNKAQLL VLLTLLSVLF SQTSAWPLYR APSALRLGDR IPFEGANEPD 
        60         70         80         90        100
QVSLKEDIDM LQNALAENDT PYYDVSRNAR HADGVFTSDF SKLLGQLSAK 
       110        120        130        140        150
KYLESLMGKR VSSNISEDPV PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI 
       160        170
LNGKRSSEGE SPDFPEELEK
Length:170
Mass (Da):19,169
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93EC0177F89508FD
GO
Isoform 2 (identifier: P01282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: Missing.

Show »
Length:169
Mass (Da):19,082
Checksum:iF325BDFEF47132C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y763H0Y763_HUMAN
VIP peptides
VIP
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96 – 97QL → PP in AAA61286 (PubMed:3748844).Curated2
Sequence conflicti116S → L in AAA61288 (PubMed:3025882).Curated1
Sequence conflicti136R → G in AAA61288 (PubMed:3025882).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023256113Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L00157 L00156 Genomic DNA Translation: AAA61289.1
M11553 M11552 Genomic DNA Translation: AAA61284.1
M36634 mRNA Translation: AAA61287.1
M14623 M14622 Genomic DNA Translation: AAA61288.1
M33027 Genomic DNA Translation: AAA69515.1
AL133356 Genomic DNA No translation available.
BC009794 mRNA Translation: AAH09794.1
M36610 M36609 Genomic DNA Translation: AAA61286.1
M54930 mRNA Translation: AAA63268.1
M32162, M31645 Genomic DNA Translation: AAA61285.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5240.1 [P01282-1]
CCDS5241.1 [P01282-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A23296, VRHU

NCBI Reference Sequences

More...RefSeqi		NP_003372.1, NM_003381.3 [P01282-1]
NP_919416.1, NM_194435.2 [P01282-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367243; ENSP00000356212; ENSG00000146469 [P01282-2]
ENST00000367244; ENSP00000356213; ENSG00000146469

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7432

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7432

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000367244.8; ENSP00000356213.3; NM_003381.4; NP_003372.1

UCSC genome browser

More...UCSCi		uc003qpe.6, human [P01282-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Vasoactive intestinal peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00157 L00156 Genomic DNA Translation: AAA61289.1
M11553 M11552 Genomic DNA Translation: AAA61284.1
M36634 mRNA Translation: AAA61287.1
M14623 M14622 Genomic DNA Translation: AAA61288.1
M33027 Genomic DNA Translation: AAA69515.1
AL133356 Genomic DNA No translation available.
BC009794 mRNA Translation: AAH09794.1
M36610 M36609 Genomic DNA Translation: AAA61286.1
M54930 mRNA Translation: AAA63268.1
M32162, M31645 Genomic DNA Translation: AAA61285.1
CCDSiCCDS5240.1 [P01282-1]
CCDS5241.1 [P01282-2]
PIRiA23296, VRHU
RefSeqiNP_003372.1, NM_003381.3 [P01282-1]
NP_919416.1, NM_194435.2 [P01282-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RRHNMR-A125-153[»]
2RRINMR-A125-153[»]
BMRBiP01282
SMRiP01282
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113273, 16 interactors
IntActiP01282, 14 interactors
MINTiP01282
STRINGi9606.ENSP00000356213

Chemistry databases

BindingDBiP01282
ChEMBLiCHEMBL5737

PTM databases

iPTMnetiP01282
PhosphoSitePlusiP01282

Genetic variation databases

BioMutaiVIP
DMDMi138574

Proteomic databases

MassIVEiP01282
PaxDbiP01282
PeptideAtlasiP01282
PRIDEiP01282
ProteomicsDBi51368 [P01282-1]
51369 [P01282-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P01282, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3435, 559 antibodies from 41 providers

The DNASU plasmid repository

More...DNASUi		7432

Genome annotation databases

EnsembliENST00000367243; ENSP00000356212; ENSG00000146469 [P01282-2]
ENST00000367244; ENSP00000356213; ENSG00000146469
GeneIDi7432
KEGGihsa:7432
MANE-SelectiENST00000367244.8; ENSP00000356213.3; NM_003381.4; NP_003372.1
UCSCiuc003qpe.6, human [P01282-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7432
DisGeNETi7432

GeneCards: human genes, protein and diseases

More...GeneCardsi		VIP
HGNCiHGNC:12693, VIP
HPAiENSG00000146469, Tissue enhanced (intestine, lymphoid tissue)
MIMi192320, gene
neXtProtiNX_P01282
OpenTargetsiENSG00000146469
PharmGKBiPA37312
VEuPathDBiHostDB:ENSG00000146469

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVTA, Eukaryota
GeneTreeiENSGT00950000183154
HOGENOMiCLU_133877_1_0_1
InParanoidiP01282
OMAiVSRNTRH
OrthoDBi1343108at2759
PhylomeDBiP01282
TreeFamiTF332804

Enzyme and pathway databases

PathwayCommonsiP01282
ReactomeiR-HSA-418555, G alpha (s) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
SignaLinkiP01282
SIGNORiP01282

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7432, 7 hits in 1033 CRISPR screens
EvolutionaryTraceiP01282

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Vasoactive_intestinal_peptide

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7432
PharosiP01282, Tbio

Protein Ontology

More...PROi		PR:P01282
RNActiP01282, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000146469, Expressed in vermiform appendix and 141 other tissues
ExpressionAtlasiP01282, baseline and differential
GenevisibleiP01282, HS

Family and domain databases

InterProiView protein in InterPro
IPR015550, Glucagon
IPR000532, Glucagon_GIP_secretin_VIP
IPR015523, VIP
PANTHERiPTHR11213, PTHR11213, 1 hit
PTHR11213:SF5, PTHR11213:SF5, 1 hit
PfamiView protein in Pfam
PF00123, Hormone_2, 2 hits
SMARTiView protein in SMART
SM00070, GLUCA, 2 hits
PROSITEiView protein in PROSITE
PS00260, GLUCAGON, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVIP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01282
Secondary accession number(s): Q5TCY8, Q5TCY9, Q96QK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 23, 2022
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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