UniProtKB - P01282 (VIP_HUMAN)
VIP peptides
VIP
Functioni
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
1 PublicationPHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
1 PublicationGO - Molecular functioni
- hormone activity Source: BHF-UCL
- neuropeptide hormone activity Source: GO_Central
- peptide hormone receptor binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- antibacterial humoral response Source: UniProtKB
- antifungal humoral response Source: UniProtKB
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- body fluid secretion Source: ProtInc
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
- epinephrine secretion Source: GO_Central
- G protein-coupled receptor signaling pathway Source: ProtInc
- innate immune response Source: UniProtKB
- learning or memory Source: GO_Central
- mRNA stabilization Source: AgBase
- negative regulation of apoptotic process Source: GO_Central
- negative regulation of potassium ion transport Source: GO_Central
- negative regulation of smooth muscle cell proliferation Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of endothelial cell proliferation Source: GO_Central
- positive regulation of epinephrine secretion Source: GO_Central
- positive regulation of penile erection Source: GO_Central
- positive regulation of protein catabolic process Source: BHF-UCL
- prolactin secretion Source: AgBase
- regulation of protein localization Source: BHF-UCL
- regulation of sensory perception of pain Source: GO_Central
- response to yeast Source: UniProtKB
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | P01282 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P01282 |
SIGNORi | P01282 |
Names & Taxonomyi
Protein namesi | Recommended name: VIP peptidesCleaved into the following 3 chains: Alternative name(s): Peptide histidine valine 42 Alternative name(s): Peptide histidine methioninamide 27 Alternative name(s): Vasoactive intestinal polypeptide |
Gene namesi | Name:VIP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12693, VIP |
MIMi | 192320, gene |
neXtProti | NX_P01282 |
VEuPathDBi | HostDB:ENSG00000146469 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
Other locations
- neuron projection Source: GO_Central
- perikaryon Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 7432 |
OpenTargetsi | ENSG00000146469 |
PharmGKBi | PA37312 |
Miscellaneous databases
Pharosi | P01282, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5737 |
Genetic variation databases
BioMutai | VIP |
DMDMi | 138574 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000011457 | 21 – 79 | Add BLAST | 59 | |
PeptideiPRO_0000011458 | 81 – 122 | Intestinal peptide PHV-42Add BLAST | 42 | |
PeptideiPRO_0000011459 | 81 – 107 | Intestinal peptide PHM-27Add BLAST | 27 | |
PeptideiPRO_0000011460 | 125 – 152 | Vasoactive intestinal peptideAdd BLAST | 28 | |
PropeptideiPRO_0000011461 | 156 – 170 | Add BLAST | 15 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 76 | PhosphoserineBy similarity | 1 | |
Modified residuei | 107 | Methionine amide1 Publication | 1 | |
Modified residuei | 152 | Asparagine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, PhosphoproteinProteomic databases
MassIVEi | P01282 |
PaxDbi | P01282 |
PeptideAtlasi | P01282 |
PRIDEi | P01282 |
ProteomicsDBi | 51368 [P01282-1] 51369 [P01282-2] |
PTM databases
iPTMneti | P01282 |
PhosphoSitePlusi | P01282 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146469, Expressed in vermiform appendix and 141 other tissues |
ExpressionAtlasi | P01282, baseline and differential |
Genevisiblei | P01282, HS |
Organism-specific databases
HPAi | ENSG00000146469, Tissue enhanced (intestine, lymphoid tissue) |
Interactioni
Binary interactionsi
P01282
With | #Exp. | IntAct |
---|---|---|
DPP4 [P27487] | 2 | EBI-751454,EBI-2871277 |
FAP [Q12884] | 2 | EBI-751454,EBI-4319803 |
SGTA [O43765] | 3 | EBI-751454,EBI-347996 |
Isoform 2 [P01282-2]
With | #Exp. | IntAct |
---|---|---|
CTNNA3 - isoform 2 [Q9UI47-2] | 3 | EBI-12320391,EBI-11962928 |
MGST1 [P10620] | 3 | EBI-12320391,EBI-2691601 |
UBQLN2 [Q9UHD9] | 3 | EBI-12320391,EBI-947187 |
Vasoactive intestinal peptide (PRO_0000011460)
With | #Exp. | IntAct |
---|---|---|
VIPR1 [P32241] | 2 | EBI-6656819,EBI-3917984 |
GO - Molecular functioni
- hormone activity Source: BHF-UCL
- neuropeptide hormone activity Source: GO_Central
- peptide hormone receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 113273, 16 interactors |
IntActi | P01282, 14 interactors |
MINTi | P01282 |
STRINGi | 9606.ENSP00000356213 |
Chemistry databases
BindingDBi | P01282 |
Miscellaneous databases
RNActi | P01282, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P01282 |
SMRi | P01282 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01282 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QVTA, Eukaryota |
GeneTreei | ENSGT00950000183154 |
HOGENOMi | CLU_133877_1_0_1 |
InParanoidi | P01282 |
OMAi | VSRNTRH |
OrthoDBi | 1343108at2759 |
PhylomeDBi | P01282 |
TreeFami | TF332804 |
Family and domain databases
InterProi | View protein in InterPro IPR015550, Glucagon IPR000532, Glucagon_GIP_secretin_VIP IPR015523, VIP |
PANTHERi | PTHR11213, PTHR11213, 1 hit PTHR11213:SF5, PTHR11213:SF5, 1 hit |
Pfami | View protein in Pfam PF00123, Hormone_2, 2 hits |
SMARTi | View protein in SMART SM00070, GLUCA, 2 hits |
PROSITEi | View protein in PROSITE PS00260, GLUCAGON, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDTRNKAQLL VLLTLLSVLF SQTSAWPLYR APSALRLGDR IPFEGANEPD
60 70 80 90 100
QVSLKEDIDM LQNALAENDT PYYDVSRNAR HADGVFTSDF SKLLGQLSAK
110 120 130 140 150
KYLESLMGKR VSSNISEDPV PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI
160 170
LNGKRSSEGE SPDFPEELEK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y763 | H0Y763_HUMAN | VIP peptides | VIP | 119 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 96 – 97 | QL → PP in AAA61286 (PubMed:3748844).Curated | 2 | |
Sequence conflicti | 116 | S → L in AAA61288 (PubMed:3025882).Curated | 1 | |
Sequence conflicti | 136 | R → G in AAA61288 (PubMed:3025882).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023256 | 113 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00157 , L00154, L00155, L00156 Genomic DNA Translation: AAA61289.1 M11553 , M11549, M11550, M11551, M11552 Genomic DNA Translation: AAA61284.1 M36634 mRNA Translation: AAA61287.1 M14623 , M14619, M14620, M14621, M14622 Genomic DNA Translation: AAA61288.1 M33027 Genomic DNA Translation: AAA69515.1 AL133356 Genomic DNA No translation available. BC009794 mRNA Translation: AAH09794.1 M36610 , M36606, M36607, M36608, M36609 Genomic DNA Translation: AAA61286.1 M54930 mRNA Translation: AAA63268.1 M32162, M31645 Genomic DNA Translation: AAA61285.1 |
CCDSi | CCDS5240.1 [P01282-1] CCDS5241.1 [P01282-2] |
PIRi | A23296, VRHU |
RefSeqi | NP_003372.1, NM_003381.3 [P01282-1] NP_919416.1, NM_194435.2 [P01282-2] |
Genome annotation databases
Ensembli | ENST00000367243; ENSP00000356212; ENSG00000146469 [P01282-2] ENST00000367244; ENSP00000356213; ENSG00000146469 |
GeneIDi | 7432 |
KEGGi | hsa:7432 |
MANE-Selecti | ENST00000367244.8; ENSP00000356213.3; NM_003381.4; NP_003372.1 |
UCSCi | uc003qpe.6, human [P01282-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Vasoactive intestinal peptide entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00157 , L00154, L00155, L00156 Genomic DNA Translation: AAA61289.1 M11553 , M11549, M11550, M11551, M11552 Genomic DNA Translation: AAA61284.1 M36634 mRNA Translation: AAA61287.1 M14623 , M14619, M14620, M14621, M14622 Genomic DNA Translation: AAA61288.1 M33027 Genomic DNA Translation: AAA69515.1 AL133356 Genomic DNA No translation available. BC009794 mRNA Translation: AAH09794.1 M36610 , M36606, M36607, M36608, M36609 Genomic DNA Translation: AAA61286.1 M54930 mRNA Translation: AAA63268.1 M32162, M31645 Genomic DNA Translation: AAA61285.1 |
CCDSi | CCDS5240.1 [P01282-1] CCDS5241.1 [P01282-2] |
PIRi | A23296, VRHU |
RefSeqi | NP_003372.1, NM_003381.3 [P01282-1] NP_919416.1, NM_194435.2 [P01282-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RRH | NMR | - | A | 125-153 | [»] | |
2RRI | NMR | - | A | 125-153 | [»] | |
BMRBi | P01282 | |||||
SMRi | P01282 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113273, 16 interactors |
IntActi | P01282, 14 interactors |
MINTi | P01282 |
STRINGi | 9606.ENSP00000356213 |
Chemistry databases
BindingDBi | P01282 |
ChEMBLi | CHEMBL5737 |
PTM databases
iPTMneti | P01282 |
PhosphoSitePlusi | P01282 |
Genetic variation databases
BioMutai | VIP |
DMDMi | 138574 |
Proteomic databases
MassIVEi | P01282 |
PaxDbi | P01282 |
PeptideAtlasi | P01282 |
PRIDEi | P01282 |
ProteomicsDBi | 51368 [P01282-1] 51369 [P01282-2] |
Protocols and materials databases
ABCDi | P01282, 2 sequenced antibodies |
Antibodypediai | 3435, 559 antibodies from 41 providers |
DNASUi | 7432 |
Genome annotation databases
Ensembli | ENST00000367243; ENSP00000356212; ENSG00000146469 [P01282-2] ENST00000367244; ENSP00000356213; ENSG00000146469 |
GeneIDi | 7432 |
KEGGi | hsa:7432 |
MANE-Selecti | ENST00000367244.8; ENSP00000356213.3; NM_003381.4; NP_003372.1 |
UCSCi | uc003qpe.6, human [P01282-1] |
Organism-specific databases
CTDi | 7432 |
DisGeNETi | 7432 |
GeneCardsi | VIP |
HGNCi | HGNC:12693, VIP |
HPAi | ENSG00000146469, Tissue enhanced (intestine, lymphoid tissue) |
MIMi | 192320, gene |
neXtProti | NX_P01282 |
OpenTargetsi | ENSG00000146469 |
PharmGKBi | PA37312 |
VEuPathDBi | HostDB:ENSG00000146469 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVTA, Eukaryota |
GeneTreei | ENSGT00950000183154 |
HOGENOMi | CLU_133877_1_0_1 |
InParanoidi | P01282 |
OMAi | VSRNTRH |
OrthoDBi | 1343108at2759 |
PhylomeDBi | P01282 |
TreeFami | TF332804 |
Enzyme and pathway databases
PathwayCommonsi | P01282 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P01282 |
SIGNORi | P01282 |
Miscellaneous databases
BioGRID-ORCSi | 7432, 7 hits in 1033 CRISPR screens |
EvolutionaryTracei | P01282 |
GeneWikii | Vasoactive_intestinal_peptide |
GenomeRNAii | 7432 |
Pharosi | P01282, Tbio |
PROi | PR:P01282 |
RNActi | P01282, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146469, Expressed in vermiform appendix and 141 other tissues |
ExpressionAtlasi | P01282, baseline and differential |
Genevisiblei | P01282, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015550, Glucagon IPR000532, Glucagon_GIP_secretin_VIP IPR015523, VIP |
PANTHERi | PTHR11213, PTHR11213, 1 hit PTHR11213:SF5, PTHR11213:SF5, 1 hit |
Pfami | View protein in Pfam PF00123, Hormone_2, 2 hits |
SMARTi | View protein in SMART SM00070, GLUCA, 2 hits |
PROSITEi | View protein in PROSITE PS00260, GLUCAGON, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | VIP_HUMAN | |
Accessioni | P01282Primary (citable) accession number: P01282 Secondary accession number(s): Q5TCY8, Q5TCY9, Q96QK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 205 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families