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Protein

Parathyroid hormone

Gene

PTH

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-SSC-373080 Class B/2 (Secretin family receptors)
R-SSC-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Alternative name(s):
Parathyrin
Gene namesi
Name:PTH
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
PropeptideiPRO_000002325326 – 311 Publication6
ChainiPRO_000002325432 – 115Parathyroid hormoneAdd BLAST84

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01269
PRIDEiP01269

Expressioni

Gene expression databases

ExpressionAtlasiP01269 baseline
GenevisibleiP01269 SS

Interactioni

Subunit structurei

Interacts with PTH1R (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014236

Structurei

3D structure databases

ProteinModelPortaliP01269
SMRiP01269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 69Important for receptor bindingBy similarityAdd BLAST19

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J02X Eukaryota
ENOG410ZH2H LUCA
GeneTreeiENSGT00390000018603
HOGENOMiHOG000033707
HOVERGENiHBG008319
InParanoidiP01269
KOiK05261
OrthoDBiEOG091G13ZF

Family and domain databases

InterProiView protein in InterPro
IPR003625 PTH
IPR001415 PTH/PTH-rel
PANTHERiPTHR10541:SF2 PTHR10541:SF2, 1 hit
PfamiView protein in Pfam
PF01279 Parathyroid, 1 hit
PIRSFiPIRSF001832 PTH, 1 hit
SMARTiView protein in SMART
SM00087 PTH, 1 hit
PROSITEiView protein in PROSITE
PS00335 PARATHYROID, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSAKDTVKV MVVMLAICFL ARSDGKPIKK RSVSEIQLMH NLGKHLSSLE
60 70 80 90 100
RVEWLRKKLQ DVHNFVALGA SIVHRDGGSQ RPRKKEDNVL VESHQKSLGE
110
ADKAAVDVLI KAKPQ
Length:115
Mass (Da):12,852
Last modified:January 1, 1988 - v1
Checksum:i9FE8BCDE614BAC16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05722 mRNA Translation: CAA29193.1
PIRiB26806 PTPG
RefSeqiNP_999566.1, NM_214401.1
UniGeneiSsc.668

Genome annotation databases

EnsembliENSSSCT00000014631; ENSSSCP00000014236; ENSSSCG00000013394
GeneIDi399502
KEGGissc:399502

Similar proteinsi

Entry informationi

Entry nameiPTHY_PIG
AccessioniPrimary (citable) accession number: P01269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: July 18, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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