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Entry version 148 (03 Jul 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Thyroglobulin

Gene

TG

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processThyroid hormones biosynthesis

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
bovin-thyro Thyroglobulin

MEROPS protease database

More...
MEROPSi
I31.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroglobulin
Short name:
Tg
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
11790 Bos d TG

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Add BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000863520 – 2769ThyroglobulinAdd BLAST2750

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24Iodotyrosine; alternateBy similarity1
Modified residuei24Sulfotyrosine; alternateBy similarity1
Modified residuei24Thyroxine; alternateBy similarity1
Modified residuei24Triiodothyronine; alternateBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 52PROSITE-ProRule annotation
Disulfide bondi63 ↔ 70PROSITE-ProRule annotation
Disulfide bondi72 ↔ 92PROSITE-ProRule annotation
Disulfide bondi96 ↔ 120PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi110N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Disulfide bondi131 ↔ 138PROSITE-ProRule annotation
Disulfide bondi140 ↔ 160PROSITE-ProRule annotation
Modified residuei149Diiodotyrosine; alternateBy similarity1
Modified residuei149Iodotyrosine; alternateBy similarity1
Disulfide bondi164 ↔ 183PROSITE-ProRule annotation
Disulfide bondi194 ↔ 235PROSITE-ProRule annotation
Modified residuei258IodotyrosineBy similarity1
Disulfide bondi301 ↔ 319PROSITE-ProRule annotation
Disulfide bondi330 ↔ 336PROSITE-ProRule annotation
Disulfide bondi338 ↔ 358PROSITE-ProRule annotation
Glycosylationi483N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi483N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Glycosylationi495N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi495N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Disulfide bondi607 ↔ 619PROSITE-ProRule annotation
Disulfide bondi630 ↔ 635PROSITE-ProRule annotation
Disulfide bondi637 ↔ 657PROSITE-ProRule annotation
Disulfide bondi661 ↔ 686PROSITE-ProRule annotation
Disulfide bondi697 ↔ 702PROSITE-ProRule annotation
Modified residuei703Diiodotyrosine; alternateBy similarity1
Modified residuei703Iodotyrosine; alternateBy similarity1
Modified residuei703Thyroxine; alternateBy similarity1
Modified residuei703Triiodothyronine; alternateBy similarity1
Disulfide bondi704 ↔ 725PROSITE-ProRule annotation
Disulfide bondi729 ↔ 762PROSITE-ProRule annotation
Disulfide bondi773 ↔ 898PROSITE-ProRule annotation
Modified residuei784IodotyrosineBy similarity1
Glycosylationi853N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi853N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Modified residuei866Diiodotyrosine; alternateBy similarity1
Modified residuei866Iodotyrosine; alternateBy similarity1
Modified residuei883DiiodotyrosineBy similarity1
Disulfide bondi900 ↔ 921PROSITE-ProRule annotation
Glycosylationi947N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi947N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Modified residuei992Diiodotyrosine; alternateBy similarity1
Modified residuei992Iodotyrosine; alternateBy similarity1
Disulfide bondi1042 ↔ 1049PROSITE-ProRule annotation
Disulfide bondi1051 ↔ 1073PROSITE-ProRule annotation
Disulfide bondi1077 ↔ 1108PROSITE-ProRule annotation
Disulfide bondi1126 ↔ 1145PROSITE-ProRule annotation
Glycosylationi1140N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi1140N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Disulfide bondi1149 ↔ 1169PROSITE-ProRule annotation
Disulfide bondi1181 ↔ 1188PROSITE-ProRule annotation
Disulfide bondi1190 ↔ 1210PROSITE-ProRule annotation
Modified residuei1310IodotyrosineBy similarity1
Glycosylationi1365N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Modified residuei1469Diiodotyrosine; alternateBy similarity1
Modified residuei1469Iodotyrosine; alternateBy similarity1
Disulfide bondi1516 ↔ 1525PROSITE-ProRule annotation
Disulfide bondi1545 ↔ 1567PROSITE-ProRule annotation
Glycosylationi1776N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi1776N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Glycosylationi1870N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi1870N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Glycosylationi2014N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi2123N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Modified residuei2185IodotyrosineBy similarity1
Glycosylationi2251N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi2251N-linked (GlcNAc...) (hybrid) asparagine; alternate1 Publication1
Glycosylationi2296N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Modified residuei2574Diiodotyrosine; alternateBy similarity1
Modified residuei2574Iodotyrosine; alternateBy similarity1
Modified residuei2574Thyroxine; alternateBy similarity1
Modified residuei2574Triiodothyronine; alternateBy similarity1
Modified residuei2588IodotyrosineBy similarity1
Modified residuei2618IodotyrosineBy similarity1
Modified residuei2698DiiodotyrosineBy similarity1
Modified residuei2767Diiodotyrosine; alternateBy similarity1
Modified residuei2767Iodotyrosine; alternateBy similarity1
Modified residuei2767Thyroxine; alternateBy similarity1
Modified residuei2767Triiodothyronine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated tyrosines are desulfated during iodination.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei198Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Iodination, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01267

PRoteomics IDEntifications database

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PRIDEi
P01267

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
598

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P01267

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01267

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Thyroid gland specific.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000010295

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01267

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 92Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST62
Domaini93 – 160Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST68
Domaini161 – 297Thyroglobulin type-1 3PROSITE-ProRule annotationAdd BLAST137
Domaini298 – 358Thyroglobulin type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini604 – 657Thyroglobulin type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini658 – 725Thyroglobulin type-1 6PROSITE-ProRule annotationAdd BLAST68
Domaini726 – 921Thyroglobulin type-1 7PROSITE-ProRule annotationAdd BLAST196
Domaini922 – 1073Thyroglobulin type-1 8PROSITE-ProRule annotationAdd BLAST152
Domaini1074 – 1145Thyroglobulin type-1 9PROSITE-ProRule annotationAdd BLAST72
Domaini1146 – 1210Thyroglobulin type-1 10PROSITE-ProRule annotationAdd BLAST65
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1458 – 1471Type IIAdd BLAST14
Repeati1472 – 1488Type IIAdd BLAST17
Repeati1489 – 1505Type IIAdd BLAST17
Domaini1513 – 1567Thyroglobulin type-1 11PROSITE-ProRule annotationAdd BLAST55
Repeati1605 – 1725Type IIIAAdd BLAST121
Repeati1726 – 1893Type IIIBAdd BLAST168
Repeati1894 – 1996Type IIIAAdd BLAST103
Repeati1997 – 2130Type IIIBAdd BLAST134
Repeati2131 – 2188Type IIIAAdd BLAST58

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG6K Eukaryota
COG2272 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000128427

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01267

KEGG Orthology (KO)

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KOi
K10809

Database of Orthologous Groups

More...
OrthoDBi
754103at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00191 TY, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1820, 1 hit
4.10.800.10, 7 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR016324 Thyroglobulin
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00135 COesterase, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00086 Thyroglobulin_1, 10 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001831 Thyroglobulin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00211 TY, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit
SSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 9 hits
PS51162 THYROGLOBULIN_1_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01267-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALALWVFGL LDLICLASAN IFEYQVDAQP LRPCELQRER AFLKREDYVP
60 70 80 90 100
QCAEDGSFQT VQCGKDGASC WCVDADGREV PGSRQPGRPA ACLSFCQLQK
110 120 130 140 150
QQILLSSYIN STATSYLPQC QDSGDYSPVQ CDLRRRQCWC VDAEGMEVYG
160 170 180 190 200
TRQQGRPARC PRSCEIRNRR LLHGVGDRSP PQCSPDGAFR PVQCKLVNTT
210 220 230 240 250
DMMIFDLVHS YSRFPDAFVT FSSFRSRFPE VSGYCYCADS QGRELAETGL
260 270 280 290 300
ELLLDEIYDT IFAGLDLAST FAETTLYRIL QRRFLAVQLV ISGRFRCPTK
310 320 330 340 350
CEVERFAATS FRHPYVPSCH PDGEYQAAQC QQGGPCWCVD SRGQEIPGTR
360 370 380 390 400
QRGEPPSCAE DQSCPSERRR AFSRLRFGPS GYFSRRSLLL APEEGPVSQR
410 420 430 440 450
FARFTASCPP SIKELFLDSG IFQPMLQGRD TRFVAPESLK EAIRGLFPSR
460 470 480 490 500
ELARLALQFT TNAKRLQQNL FGGRFLVKVG QFNLSGALGT RGTFNFSHFF
510 520 530 540 550
QQLGLPGFQD GRALADLAKP LSVGLNSNPA SEAPKASKID VALRKPVVGS
560 570 580 590 600
FGFEVNLQEN QNALQFLSSF LELPEFLLFL QHAISVPEDI ARDLGDVMEM
610 620 630 640 650
VFSSQGCGQA PGSLFVPACT AEGSYEEVQC FAGDCWCVDA QGRELAGSRV
660 670 680 690 700
RGGRPRCPTE CEKQRARMQS LLGSQPAGSS LFVPACTSKG NFLPVQCFNS
710 720 730 740 750
ECYCVDTEGQ PIPGTRSALG EPKKCPSPCQ LQAERAFLGT VRTLVSNPST
760 770 780 790 800
LPALSSIYIP QCSASGQWSP VQCDGPPEQA FEWYERWEAQ NSAGQALTPA
810 820 830 840 850
ELLMKIMSYR EAASRNFRLF IQNLYEAGQQ GIFPGLARYS SFQDVPVSVL
860 870 880 890 900
EGNQTQPGGN VFLEPYLFWQ ILNGQLDRYP GPYSDFSAPL AHFDLRSCWC
910 920 930 940 950
VDEAGQKLEG TRNEPNKVPA CPGSCEEVKL RVLQFIREAE EIVTYSNSSR
960 970 980 990 1000
FPLGESFLAA KGIRLTDEEL AFPPLSPSRE TFLEKFLSGS DYAIRLAAQS
1010 1020 1030 1040 1050
TFDFYQRRLV TLAESPRAPS PVWSSAYLPQ CDAFGGWEPV QCHAATGHCW
1060 1070 1080 1090 1100
CVDGKGEYVP TSLTARSRQI PQCPTSCERL RASGLLSSWK QAGVQAEPSP
1110 1120 1130 1140 1150
KDLFIPTCLE TGEFARLQAS EAGTWCVDPA SGEGVPPGTN SSAQCPSLCE
1160 1170 1180 1190 1200
VLQSGVPSRR TSPGYSPACR AEDGGFSPVQ CDPAQGSCWC VLGSGEEVPG
1210 1220 1230 1240 1250
TRVAGSQPAC ESPQCPLPFS VADVAGGAIL CERASGLGAA AGQRCQLRCS
1260 1270 1280 1290 1300
QGYRSAFPPE PLLCSVQRRR WESRPPQPRA CQRPQFWQTL QTQAQFQLLL
1310 1320 1330 1340 1350
PLGKVCSADY SGLLLAFQVF LLDELTARGF CQIQVKTAGT PVSIPVCDDS
1360 1370 1380 1390 1400
SVKVECLSRE RLGVNITWKL QLVDAPPASL PDLQDVEEAL AGKYLAGRFA
1410 1420 1430 1440 1450
DLIQSGTFQL HLDSKTFSAD TSIRFLQGDR FGTSPRTQFG CLEGFGRVVA
1460 1470 1480 1490 1500
ASDASQDALG CVKCPEGSYF QDEQCIPCPA GFYQEQAGSL ACVPCPEGRT
1510 1520 1530 1540 1550
TVYAGAFSQT HCVTDCQKNE VGLQCDQDSQ YRASQRDRTS GKAFCVDGEG
1560 1570 1580 1590 1600
RRLPWTEAEA PLVDAQCLVM RKFEKLPESK VIFSADVAVM VRSEVPGSES
1610 1620 1630 1640 1650
SLMQCLADCA LDEACGFLTV STAGSEVSCD FYAWASDSIA CTTSGRSEDA
1660 1670 1680 1690 1700
LGTSQATSFG SLQCQVKVRS REGDPLAVYL KKGQEFTITG QKRFEQTGFQ
1710 1720 1730 1740 1750
SALSGMYSPV TFSASGASLA EVHLFCLLAC DHDSCCDGFI LVQVQGGPLL
1760 1770 1780 1790 1800
CGLLSSPDVL LCHVRDWRDP AEAQANASCP GVTYDQDSRQ VTLRLGGQEI
1810 1820 1830 1840 1850
RGLTPLEGTQ DTLTSFQQVY LWKDSDMGSR SESMGCRRDT EPRPASPSET
1860 1870 1880 1890 1900
DLTTGLFSPV DLIQVIVDGN VSLPSQQHWL FKHLFSLQQA NLWCLSRCAG
1910 1920 1930 1940 1950
EPSFCQLAEV TDSEPLYFTC TLYPEAQVCD DILESSPKGC RLILPRRPSA
1960 1970 1980 1990 2000
LYRKKVVLQD RVKNFYNRLP FQKLTGISIR NKVPMSDKSI SSGFFECERL
2010 2020 2030 2040 2050
CDMDPCCTGF GFLNVSQLKG GEVTCLTLNS LGLQTCSEEY GGVWRILDCG
2060 2070 2080 2090 2100
SPDTEVRTYP FGWYQKPVSP SDAPSFCPSV ALPALTENVA LDSWQSLALS
2110 2120 2130 2140 2150
SVIVDPSIRN FDVAHISTAA VGNFSAARDR CLWECSRHQD CLVTTLQTQP
2160 2170 2180 2190 2200
GAVRCMFYAD TQSCTHSLQA QNCRLLLHEE ATYIYRKPNI PLPGFGTSSP
2210 2220 2230 2240 2250
SVPIATHGQL LGRSQAIQVG TSWKPVDQFL GVPYAAPPLG EKRFRAPEHL
2260 2270 2280 2290 2300
NWTGSWEATK PRARCWQPGI RTPTPPGVSE DCLYLNVFVP QNMAPNASVL
2310 2320 2330 2340 2350
VFFHNAAEGK GSGDRPAVDG SFLAAVGNLI VVTASYRTGI FGFLSSGSSE
2360 2370 2380 2390 2400
LSGNWGLLDQ VVALTWVQTH IQAFGGDPRR VTLAADRGGA DIASIHLVTT
2410 2420 2430 2440 2450
RAANSRLFRR AVLMGGSALS PAAVIRPERA RQQAAALAKE VGCPSSSVQE
2460 2470 2480 2490 2500
MVSCLRQEPA RILNDAQTKL LAVSGPFHYW GPVVDGQYLR ETPARVLQRA
2510 2520 2530 2540 2550
PRVKVDLLIG SSQDDGLINR AKAVKQFEES QGRTSSKTAF YQALQNSLGG
2560 2570 2580 2590 2600
EAADAGVQAA ATWYYSLEHD SDDYASFSRA LEQATRDYFI ICPVIDMASH
2610 2620 2630 2640 2650
WARTVRGNVF MYHAPESYSH SSLELLTDVL YAFGLPFYPA YEGQFTLEEK
2660 2670 2680 2690 2700
SLSLKIMQYF SNFIRSGNPN YPHEFSRRAP EFAAPWPDFV PRDGAESYKE
2710 2720 2730 2740 2750
LSVLLPNRQG LKKADCSFWS KYIQSLKASA DETKDGPSAD SEEEDQPAGS
2760
GLTEDLLGLP ELASKTYSK
Length:2,769
Mass (Da):303,222
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C7F227E9101DE2A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1206S → R in CAA29457 (PubMed:3681978).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X02815 mRNA Translation: CAA26584.1
X02155 mRNA Translation: CAA26090.1
X05380 Genomic DNA Translation: CAA28971.1 Sequence problems.
X06071
, X06072, X06073, X06074, X06075 Genomic DNA Translation: CAA29457.1

Protein sequence database of the Protein Information Resource

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PIRi
A01533 UIBO

NCBI Reference Sequences

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RefSeqi
NP_776308.1, NM_173883.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
280706

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:280706

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02815 mRNA Translation: CAA26584.1
X02155 mRNA Translation: CAA26090.1
X05380 Genomic DNA Translation: CAA28971.1 Sequence problems.
X06071
, X06072, X06073, X06074, X06075 Genomic DNA Translation: CAA29457.1
PIRiA01533 UIBO
RefSeqiNP_776308.1, NM_173883.2

3D structure databases

SMRiP01267
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010295

Protein family/group databases

Allergomei11790 Bos d TG
ESTHERibovin-thyro Thyroglobulin
MEROPSiI31.950

PTM databases

GlyConnecti598
iPTMnetiP01267
UniCarbKBiP01267

Proteomic databases

PaxDbiP01267
PRIDEiP01267

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P01267
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280706
KEGGibta:280706

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7038

Phylogenomic databases

eggNOGiENOG410IG6K Eukaryota
COG2272 LUCA
HOGENOMiHOG000128427
InParanoidiP01267
KOiK10809
OrthoDBi754103at2759

Family and domain databases

CDDicd00191 TY, 8 hits
Gene3Di3.40.50.1820, 1 hit
4.10.800.10, 7 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR016324 Thyroglobulin
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00086 Thyroglobulin_1, 10 hits
PIRSFiPIRSF001831 Thyroglobulin, 1 hit
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00211 TY, 10 hits
SUPFAMiSSF53474 SSF53474, 1 hit
SSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 11 hits
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 9 hits
PS51162 THYROGLOBULIN_1_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHYG_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01267
Secondary accession number(s): O18976, Q28196, Q95478
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 3, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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