UniProtKB - P01266 (THYG_HUMAN)
Protein
Thyroglobulin
Gene
TG
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030).2 Publications
Caution
The cholinesterase-like (ChEL) region lacks the Ser residue of the catalytic triad suggesting that it has no esterase activity.Curated
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- identical protein binding Source: UniProtKB
GO - Biological processi
- hormone biosynthetic process Source: UniProtKB-KW
- iodide transport Source: Ensembl
- regulation of myelination Source: Ensembl
- signal transduction Source: ProtInc
- thyroid gland development Source: UniProtKB
- thyroid hormone generation Source: UniProtKB
Keywordsi
Molecular function | Hormone, Thyroid hormone |
Biological process | Thyroid hormones biosynthesis |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000042832-MONOMER |
PathwayCommonsi | P01266 |
SIGNORi | P01266 |
Protein family/group databases
ESTHERi | human-TG, Thyroglobulin |
MEROPSi | I31.950 |
Names & Taxonomyi
Protein namesi | Recommended name: ThyroglobulinCuratedShort name: Tg |
Gene namesi | Name:TGImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11764, TG |
MIMi | 188450, gene |
neXtProti | NX_P01266 |
VEuPathDBi | HostDB:ENSG00000042832.11 |
Subcellular locationi
Extracellular region or secreted
- Secreted 3 Publications
Note: Secreted into the thyroid follicle lumen (PubMed:19509106). Localizes to colloid globules, a structure formed in the thyroid follicle lumen consisting of cross-linked TG arranged in concentric layers (PubMed:8626858, PubMed:11082042).3 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Thyroid dyshormonogenesis 3 (TDH3)6 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063034 | 183 | C → Y in TDH3. 1 Publication | 1 | |
Natural variantiVAR_010216 | 1264 | C → R in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076738Ensembl. | 1 | |
Natural variantiVAR_063035 | 1897 | C → Y in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912649EnsemblClinVar. | 1 | |
Natural variantiVAR_010219 | 1996 | C → S in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076739EnsemblClinVar. | 1 | |
Natural variantiVAR_063036 | 2234 | A → D in TDH3; reduces thyroglobulin synthesis and secretion; promotes thyroglobulin retention within the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs370991693Ensembl. | 1 | |
Natural variantiVAR_078338 | 2336 – 2768 | Missing in TDH3; unknown pathological significance. 1 PublicationAdd BLAST | 433 | |
Natural variantiVAR_063037 | 2336 | R → Q in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912650EnsemblClinVar. | 1 | |
Natural variantiVAR_063038 | 2375 | G → R in TDH3. 1 PublicationCorresponds to variant dbSNP:rs137854434EnsemblClinVar. | 1 |
Autoimmune thyroid disease 3 (AITD3)2 Publications
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA complex autoimmune disorder comprising two related diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2 differentiation and activate B-cells to produce antibodies against the TSH receptor, which stimulate the thyroid and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010215 | 1028 | M → V in AITD3; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs853326EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 24 | Y → F: Abolishes thyroxine (T4) production; when associated with F-1310, F-2573 and F-2766. 1 Publication | 1 | |
Mutagenesisi | 108 | Y → F: Severe loss of thyroxine (T4) production; when associated with F-149 or F-234, and F-2540 and F-2766. Abolishes thyroxine (T4) production; when associated with F-149, F-234, F-2540 and F-2766. 1 Publication | 1 | |
Mutagenesisi | 149 | Y → F: Severe loss of thyroxine (T4) production; when associated with F-108, F-2540 and F-2766. Abolishes thyroxine (T4) production; when associated with F-108, F-234, F-2540 and F-2766. 1 Publication | 1 | |
Mutagenesisi | 234 | Y → F: Severe loss of thyroxine (T4) production; when associated with F-108, F-2540 and F-2766. Abolishes thyroxine (T4) production; when associated with F-108, F-149, F-2540 and F-2766. 1 Publication | 1 | |
Mutagenesisi | 1309 | D → S: Abolishes thyroxine (T4) production. 1 Publication | 1 | |
Mutagenesisi | 1310 | Y → F: Abolishes thyroxine (T4) production; when associated with F-24, F-2573 and F-2766. 1 Publication | 1 | |
Mutagenesisi | 2540 | Y → F: Severe loss of thyroxine (T4) production; when associated with F-149 or F-234, and F-108 and F-2766. Abolishes thyroxine (T4) production; when associated with F-108, F-149, F-234 and F-2766. 1 Publication | 1 | |
Mutagenesisi | 2573 | Y → F: Abolishes thyroxine (T4) production; when associated with F-24, F-1310 and F-2766. 1 Publication | 1 | |
Mutagenesisi | 2766 | Y → F: Abolishes thyroxine (T4) production; when associated with F-24, F-1310 and F-2573. 1 Publication | 1 | |
Mutagenesisi | 2766 | Y → F: Severe loss of thyroxine (T4) production; when associated with F-149 or F-234, and F-108 and F-2540. Abolishes thyroxine (T4) production; when associated with F-108, F-149, F-234 and F-2540. 1 Publication | 1 |
Keywords - Diseasei
Congenital hypothyroidism, Disease variantOrganism-specific databases
DisGeNETi | 7038 |
MalaCardsi | TG |
MIMi | 274700, phenotype 608175, phenotype |
OpenTargetsi | ENSG00000042832 |
Orphaneti | 95716, Familial thyroid dyshormonogenesis |
PharmGKBi | PA36479 |
Miscellaneous databases
Pharosi | P01266, Tbio |
Chemistry databases
DrugBanki | DB05382, Iodine |
Genetic variation databases
BioMutai | TG |
DMDMi | 126302607 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | By similarityAdd BLAST | 19 | |
ChainiPRO_0000008636 | 20 – 2768 | ThyroglobulinAdd BLAST | 2749 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | Iodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 24 | Sulfotyrosine; alternateBy similarity | 1 | |
Modified residuei | 24 | Thyroxine; alternate1 Publication1 Publication | 1 | |
Modified residuei | 24 | Triiodothyronine; alternate1 Publication | 1 | |
Disulfide bondi | 34 ↔ 52 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 63 ↔ 70 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 72 ↔ 92 | PROSITE-ProRule annotation1 PublicationImported | ||
Glycosylationi | 76 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Disulfide bondi | 96 ↔ 120 | PROSITE-ProRule annotation1 PublicationImported | ||
Modified residuei | 108 | Iodotyrosine1 Publication | 1 | |
Glycosylationi | 110 | N-linked (GlcNAc...) asparagine1 PublicationImported | 1 | |
Disulfide bondi | 131 ↔ 138 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 140 ↔ 160 | PROSITE-ProRule annotation1 PublicationImported | ||
Modified residuei | 149 | Diiodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 149 | Iodotyrosine; alternate1 Publication1 Publication | 1 | |
Disulfide bondi | 164 ↔ 183 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 194 ↔ 235 | PROSITE-ProRule annotation1 PublicationImported | ||
Glycosylationi | 198 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Modified residuei | 234 | Iodotyrosine1 Publication | 1 | |
Disulfide bondi | 237 ↔ 297 | 1 PublicationImported | ||
Modified residuei | 258 | Iodotyrosine1 Publication | 1 | |
Disulfide bondi | 301 ↔ 319 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 330 ↔ 336 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 338 ↔ 358 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 364 ↔ 620 | 1 PublicationImported | ||
Disulfide bondi | 408 ↔ 608 | 1 PublicationImported | ||
Glycosylationi | 484 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Glycosylationi | 529 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 631 ↔ 636 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 638 ↔ 658 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 662 ↔ 687 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 698 ↔ 703 | PROSITE-ProRule annotation1 PublicationImported | ||
Modified residuei | 704 | Diiodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 704 | Iodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 704 | Thyroxine; alternate1 Publication | 1 | |
Modified residuei | 704 | Triiodothyronine; alternate1 Publication | 1 | |
Disulfide bondi | 705 ↔ 726 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 730 ↔ 763 | PROSITE-ProRule annotation1 PublicationImported | ||
Glycosylationi | 748 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 774 ↔ 898 | PROSITE-ProRule annotation1 PublicationImported | ||
Modified residuei | 785 | Iodotyrosine1 Publication | 1 | |
Glycosylationi | 816 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 866 | Diiodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 866 | Iodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 883 | Diiodotyrosine1 Publication | 1 | |
Disulfide bondi | 900 ↔ 921 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 925 ↔ 1031 | 1 PublicationImported | ||
Glycosylationi | 947 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Modified residuei | 992 | Diiodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 992 | Iodotyrosine; alternate1 Publication | 1 | |
Disulfide bondi | 1042 ↔ 1049 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1051 ↔ 1073 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1077 ↔ 1108 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1126 ↔ 1145 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1149 ↔ 1169 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1181 ↔ 1188 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1190 ↔ 1210 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1215 ↔ 1264 | 1 PublicationImported | ||
Glycosylationi | 1220 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Disulfide bondi | 1231 ↔ 1245 | 1 PublicationImported | ||
Disulfide bondi | 1306 ↔ 1356 | 1 PublicationImported | ||
Modified residuei | 1310 | Iodotyrosine1 Publication | 1 | |
Modified residuei | 1310 | Thyroxine1 Publication1 Publication | 1 | |
Disulfide bondi | 1331 ↔ 1347 | 1 PublicationImported | ||
Glycosylationi | 1348 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1349 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Glycosylationi | 1365 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Disulfide bondi | 1440 ↔ 1459 | 1 PublicationImported | ||
Disulfide bondi | 1462 ↔ 1473 | 1 PublicationImported | ||
Modified residuei | 1467 | Diiodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 1467 | Iodotyrosine; alternate1 Publication | 1 | |
Disulfide bondi | 1476 ↔ 1490 | 1 PublicationImported | ||
Disulfide bondi | 1493 ↔ 1510 | 1 PublicationImported | ||
Disulfide bondi | 1514 ↔ 1523 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1543 ↔ 1565 | PROSITE-ProRule annotation1 PublicationImported | ||
Disulfide bondi | 1603 ↔ 1627 | 1 PublicationImported | ||
Disulfide bondi | 1607 ↔ 1613 | 1 PublicationImported | ||
Disulfide bondi | 1639 ↔ 1662 | 1 PublicationImported | ||
Glycosylationi | 1716 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Disulfide bondi | 1724 ↔ 1749 | 1 PublicationImported | ||
Disulfide bondi | 1728 ↔ 1734 | 1 PublicationImported | ||
Disulfide bondi | 1733 ↔ 1835 | 1 PublicationImported | ||
Disulfide bondi | 1760 ↔ 1777 | 1 PublicationImported | ||
Glycosylationi | 1774 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Glycosylationi | 1869 | N-linked (GlcNAc...) asparagine1 PublicationImported | 1 | |
Disulfide bondi | 1893 ↔ 1919 | 1 PublicationImported | ||
Disulfide bondi | 1897 ↔ 1904 | 1 PublicationImported | ||
Disulfide bondi | 1928 ↔ 1939 | 1 PublicationImported | ||
Disulfide bondi | 1996 ↔ 2024 | 1 PublicationImported | ||
Disulfide bondi | 2000 ↔ 2006 | 1 PublicationImported | ||
Disulfide bondi | 2005 ↔ 2076 | 1 PublicationImported | ||
Glycosylationi | 2013 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Disulfide bondi | 2035 ↔ 2048 | 1 PublicationImported | ||
Glycosylationi | 2122 | N-linked (GlcNAc...) asparagine1 PublicationImported | 1 | |
Disulfide bondi | 2130 ↔ 2154 | 1 PublicationImported | ||
Disulfide bondi | 2134 ↔ 2140 | 1 PublicationImported | ||
Disulfide bondi | 2163 ↔ 2172 | 1 PublicationImported | ||
Modified residuei | 2184 | Iodotyrosine1 Publication | 1 | |
Glycosylationi | 2250 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Disulfide bondi | 2264 ↔ 2281 | PROSITE-ProRule annotation1 PublicationImported | ||
Glycosylationi | 2295 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Disulfide bondi | 2442 ↔ 2453 | 1 PublicationImported | ||
Modified residuei | 2540 | Iodotyrosine1 Publication | 1 | |
Modified residuei | 2573 | Diiodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 2573 | Iodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 2573 | Thyroxine; alternate1 Publication1 Publication | 1 | |
Modified residuei | 2573 | Triiodothyronine; alternate1 Publication | 1 | |
Glycosylationi | 2582 | N-linked (GlcNAc...) asparagine2 PublicationsImported | 1 | |
Modified residuei | 2587 | Iodotyrosine1 Publication | 1 | |
Disulfide bondi | 2591 ↔ 2715 | 1 PublicationImported | ||
Modified residuei | 2617 | Iodotyrosine1 Publication | 1 | |
Modified residuei | 2697 | Diiodotyrosine1 Publication | 1 | |
Glycosylationi | 2749 | O-linked (Xyl...) (chondroitin sulfate) serine1 Publication | 1 | |
Modified residuei | 2766 | Diiodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 2766 | Iodotyrosine; alternate1 Publication | 1 | |
Modified residuei | 2766 | Thyroxine; alternate1 Publication1 Publication | 1 | |
Modified residuei | 2766 | Triiodothyronine; alternate1 Publication | 1 |
Post-translational modificationi
Iodinated on tyrosine residues by TPO (PubMed:2760035, PubMed:32025030). There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2573 is coupled to donor Tyr-2540, acceptor Tyr-2766 in monomer 1 is coupled to donor Tyr-2766 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-108 in monomer 2 (PubMed:32025030).2 Publications
Sulfated tyrosines are desulfated during iodination.1 Publication
Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones. In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL. Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4. Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 110 | Not glycosylated1 Publication | 1 | |
Sitei | 496 | Not glycosylated1 Publication | 1 | |
Sitei | 1869 | Not glycosylated1 Publication | 1 | |
Sitei | 2122 | Not glycosylated1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Iodination, Proteoglycan, SulfationProteomic databases
MassIVEi | P01266 |
PaxDbi | P01266 |
PeptideAtlasi | P01266 |
PRIDEi | P01266 |
ProteomicsDBi | 51364 [P01266-1] 51365 [P01266-2] |
PTM databases
CarbonylDBi | P01266 |
GlyConnecti | 600, 21 N-Linked glycans (1 site) |
GlyGeni | P01266, 18 sites |
iPTMneti | P01266 |
PhosphoSitePlusi | P01266 |
Expressioni
Tissue specificityi
Specifically expressed in the thyroid gland.3 Publications
Gene expression databases
Bgeei | ENSG00000042832, Expressed in thyroid gland and 128 other tissues |
ExpressionAtlasi | P01266, baseline and differential |
Genevisiblei | P01266, HS |
Organism-specific databases
HPAi | ENSG00000042832, Tissue enriched (thyroid) |
Interactioni
Subunit structurei
Binary interactionsi
P01266
With | #Exp. | IntAct |
---|---|---|
SORT1 [Q99523] | 3 | EBI-2800425,EBI-1057058 |
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112896, 3 interactors |
ELMi | P01266 |
IntActi | P01266, 4 interactors |
STRINGi | 9606.ENSP00000220616 |
Miscellaneous databases
RNActi | P01266, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 92 | Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 93 – 160 | Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 161 – 297 | Thyroglobulin type-1 3PROSITE-ProRule annotationAdd BLAST | 137 | |
Domaini | 298 – 358 | Thyroglobulin type-1 4PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 605 – 658 | Thyroglobulin type-1 5PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 659 – 726 | Thyroglobulin type-1 6PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 727 – 921 | Thyroglobulin type-1 7PROSITE-ProRule annotationAdd BLAST | 195 | |
Domaini | 922 – 1073 | Thyroglobulin type-1 8PROSITE-ProRule annotationAdd BLAST | 152 | |
Domaini | 1074 – 1145 | Thyroglobulin type-1 9PROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 1146 – 1210 | Thyroglobulin type-1 10PROSITE-ProRule annotationAdd BLAST | 65 | |
Repeati | 1456 – 1469 | Type II1 PublicationAdd BLAST | 14 | |
Repeati | 1470 – 1486 | Type II1 PublicationAdd BLAST | 17 | |
Repeati | 1487 – 1503 | Type II1 PublicationAdd BLAST | 17 | |
Domaini | 1511 – 1565 | Thyroglobulin type-1 11PROSITE-ProRule annotationAdd BLAST | 55 | |
Repeati | 1603 – 1723 | Type IIIA1 PublicationAdd BLAST | 121 | |
Repeati | 1724 – 1892 | Type IIIB1 PublicationAdd BLAST | 169 | |
Repeati | 1893 – 1995 | Type IIIA1 PublicationAdd BLAST | 103 | |
Repeati | 1996 – 2129 | Type IIIB1 PublicationAdd BLAST | 134 | |
Repeati | 2130 – 2187 | Type IIIA1 PublicationAdd BLAST | 58 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2188 – 2768 | Cholinesterase-like (ChEL)By similarityAdd BLAST | 581 |
Domaini
The cholinesterase-like (ChEL) region is required for dimerization and export from the endoplasmic reticulum.By similarity
Sequence similaritiesi
Belongs to the type-B carboxylesterase/lipase family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG1214, Eukaryota |
GeneTreei | ENSGT00940000159300 |
HOGENOMi | CLU_000943_0_0_1 |
InParanoidi | P01266 |
OMAi | DEQCIPC |
OrthoDBi | 754103at2759 |
PhylomeDBi | P01266 |
TreeFami | TF351833 |
Family and domain databases
CDDi | cd00191, TY, 7 hits |
Gene3Di | 3.40.50.1820, 1 hit 4.10.800.10, 8 hits |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019819, Carboxylesterase_B_CS IPR016324, Thyroglobulin IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf IPR011641, Tyr-kin_ephrin_A/B_rcpt-like |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit PF07699, Ephrin_rec_like, 1 hit PF00086, Thyroglobulin_1, 10 hits |
PIRSFi | PIRSF001831, Thyroglobulin, 1 hit |
SMARTi | View protein in SMART SM01411, Ephrin_rec_like, 1 hit SM00211, TY, 10 hits |
SUPFAMi | SSF53474, SSF53474, 1 hit SSF57610, SSF57610, 11 hits |
PROSITEi | View protein in PROSITE PS00941, CARBOXYLESTERASE_B_2, 1 hit PS00484, THYROGLOBULIN_1_1, 9 hits PS51162, THYROGLOBULIN_1_2, 11 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P01266-1) [UniParc]FASTAAdd to basket
Also known as: Major
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALVLEIFTL LASICWVSAN IFEYQVDAQP LRPCELQRET AFLKQADYVP
60 70 80 90 100
QCAEDGSFQT VQCQNDGRSC WCVGANGSEV LGSRQPGRPV ACLSFCQLQK
110 120 130 140 150
QQILLSGYIN STDTSYLPQC QDSGDYAPVQ CDVQQVQCWC VDAEGMEVYG
160 170 180 190 200
TRQLGRPKRC PRSCEIRNRR LLHGVGDKSP PQCSAEGEFM PVQCKFVNTT
210 220 230 240 250
DMMIFDLVHS YNRFPDAFVT FSSFQRRFPE VSGYCHCADS QGRELAETGL
260 270 280 290 300
ELLLDEIYDT IFAGLDLPST FTETTLYRIL QRRFLAVQSV ISGRFRCPTK
310 320 330 340 350
CEVERFTATS FGHPYVPSCR RNGDYQAVQC QTEGPCWCVD AQGKEMHGTR
360 370 380 390 400
QQGEPPSCAE GQSCASERQQ ALSRLYFGTS GYFSQHDLFS SPEKRWASPR
410 420 430 440 450
VARFATSCPP TIKELFVDSG LLRPMVEGQS QQFSVSENLL KEAIRAIFPS
460 470 480 490 500
RGLARLALQF TTNPKRLQQN LFGGKFLVNV GQFNLSGALG TRGTFNFSQF
510 520 530 540 550
FQQLGLASFL NGGRQEDLAK PLSVGLDSNS STGTPEAAKK DGTMNKPTVG
560 570 580 590 600
SFGFEINLQE NQNALKFLAS LLELPEFLLF LQHAISVPED VARDLGDVME
610 620 630 640 650
TVLSSQTCEQ TPERLFVPSC TTEGSYEDVQ CFSGECWCVN SWGKELPGSR
660 670 680 690 700
VRGGQPRCPT DCEKQRARMQ SLMGSQPAGS TLFVPACTSE GHFLPVQCFN
710 720 730 740 750
SECYCVDAEG QAIPGTRSAI GKPKKCPTPC QLQSEQAFLR TVQALLSNSS
760 770 780 790 800
MLPTLSDTYI PQCSTDGQWR QVQCNGPPEQ VFELYQRWEA QNKGQDLTPA
810 820 830 840 850
KLLVKIMSYR EAASGNFSLF IQSLYEAGQQ DVFPVLSQYP SLQDVPLAAL
860 870 880 890 900
EGKRPQPREN ILLEPYLFWQ ILNGQLSQYP GSYSDFSTPL AHFDLRNCWC
910 920 930 940 950
VDEAGQELEG MRSEPSKLPT CPGSCEEAKL RVLQFIRETE EIVSASNSSR
960 970 980 990 1000
FPLGESFLVA KGIRLRNEDL GLPPLFPPRE AFAEQFLRGS DYAIRLAAQS
1010 1020 1030 1040 1050
TLSFYQRRRF SPDDSAGASA LLRSGPYMPQ CDAFGSWEPV QCHAGTGHCW
1060 1070 1080 1090 1100
CVDEKGGFIP GSLTARSLQI PQCPTTCEKS RTSGLLSSWK QARSQENPSP
1110 1120 1130 1140 1150
KDLFVPACLE TGEYARLQAS GAGTWCVDPA SGEELRPGSS SSAQCPSLCN
1160 1170 1180 1190 1200
VLKSGVLSRR VSPGYVPACR AEDGGFSPVQ CDQAQGSCWC VMDSGEEVPG
1210 1220 1230 1240 1250
TRVTGGQPAC ESPRCPLPFN ASEVVGGTIL CETISGPTGS AMQQCQLLCR
1260 1270 1280 1290 1300
QGSWSVFPPG PLICSLESGR WESQLPQPRA CQRPQLWQTI QTQGHFQLQL
1310 1320 1330 1340 1350
PPGKMCSADY ADLLQTFQVF ILDELTARGF CQIQVKTFGT LVSIPVCNNS
1360 1370 1380 1390 1400
SVQVGCLTRE RLGVNVTWKS RLEDIPVASL PDLHDIERAL VGKDLLGRFT
1410 1420 1430 1440 1450
DLIQSGSFQL HLDSKTFPAE TIRFLQGDHF GTSPRTWFGC SEGFYQVLTS
1460 1470 1480 1490 1500
EASQDGLGCV KCPEGSYSQD EECIPCPVGF YQEQAGSLAC VPCPVGRTTI
1510 1520 1530 1540 1550
SAGAFSQTHC VTDCQRNEAG LQCDQNGQYR ASQKDRGSGK AFCVDGEGRR
1560 1570 1580 1590 1600
LPWWETEAPL EDSQCLMMQK FEKVPESKVI FDANAPVAVR SKVPDSEFPV
1610 1620 1630 1640 1650
MQCLTDCTED EACSFFTVST TEPEISCDFY AWTSDNVACM TSDQKRDALG
1660 1670 1680 1690 1700
NSKATSFGSL RCQVKVRSHG QDSPAVYLKK GQGSTTTLQK RFEPTGFQNM
1710 1720 1730 1740 1750
LSGLYNPIVF SASGANLTDA HLFCLLACDR DLCCDGFVLT QVQGGAIICG
1760 1770 1780 1790 1800
LLSSPSVLLC NVKDWMDPSE AWANATCPGV TYDQESHQVI LRLGDQEFIK
1810 1820 1830 1840 1850
SLTPLEGTQD TFTNFQQVYL WKDSDMGSRP ESMGCRKDTV PRPASPTEAG
1860 1870 1880 1890 1900
LTTELFSPVD LNQVIVNGNQ SLSSQKHWLF KHLFSAQQAN LWCLSRCVQE
1910 1920 1930 1940 1950
HSFCQLAEIT ESASLYFTCT LYPEAQVCDD IMESNAQGCR LILPQMPKAL
1960 1970 1980 1990 2000
FRKKVILEDK VKNFYTRLPF QKLMGISIRN KVPMSEKSIS NGFFECERRC
2010 2020 2030 2040 2050
DADPCCTGFG FLNVSQLKGG EVTCLTLNSL GIQMCSEENG GAWRILDCGS
2060 2070 2080 2090 2100
PDIEVHTYPF GWYQKPIAQN NAPSFCPLVV LPSLTEKVSL DSWQSLALSS
2110 2120 2130 2140 2150
VVVDPSIRHF DVAHVSTAAT SNFSAVRDLC LSECSQHEAC LITTLQTQPG
2160 2170 2180 2190 2200
AVRCMFYADT QSCTHSLQGQ NCRLLLREEA THIYRKPGIS LLSYEASVPS
2210 2220 2230 2240 2250
VPISTHGRLL GRSQAIQVGT SWKQVDQFLG VPYAAPPLAE RRFQAPEPLN
2260 2270 2280 2290 2300
WTGSWDASKP RASCWQPGTR TSTSPGVSED CLYLNVFIPQ NVAPNASVLV
2310 2320 2330 2340 2350
FFHNTMDREE SEGWPAIDGS FLAAVGNLIV VTASYRVGVF GFLSSGSGEV
2360 2370 2380 2390 2400
SGNWGLLDQV AALTWVQTHI RGFGGDPRRV SLAADRGGAD VASIHLLTAR
2410 2420 2430 2440 2450
ATNSQLFRRA VLMGGSALSP AAVISHERAQ QQAIALAKEV SCPMSSSQEV
2460 2470 2480 2490 2500
VSCLRQKPAN VLNDAQTKLL AVSGPFHYWG PVIDGHFLRE PPARALKRSL
2510 2520 2530 2540 2550
WVEVDLLIGS SQDDGLINRA KAVKQFEESR GRTSSKTAFY QALQNSLGGE
2560 2570 2580 2590 2600
DSDARVEAAA TWYYSLEHST DDYASFSRAL ENATRDYFII CPIIDMASAW
2610 2620 2630 2640 2650
AKRARGNVFM YHAPENYGHG SLELLADVQF ALGLPFYPAY EGQFSLEEKS
2660 2670 2680 2690 2700
LSLKIMQYFS HFIRSGNPNY PYEFSRKVPT FATPWPDFVP RAGGENYKEF
2710 2720 2730 2740 2750
SELLPNRQGL KKADCSFWSK YISSLKTSAD GAKGGQSAES EEEELTAGSG
2760
LREDLLSLQE PGSKTYSK
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBJ2 | H0YBJ2_HUMAN | Thyroglobulin | TG | 226 | Annotation score: | ||
H0YB42 | H0YB42_HUMAN | Thyroglobulin | TG | 147 | Annotation score: | ||
H0YBY1 | H0YBY1_HUMAN | Thyroglobulin | TG | 1,224 | Annotation score: | ||
E5RG33 | E5RG33_HUMAN | Thyroglobulin | TG | 59 | Annotation score: | ||
E7EVM0 | E7EVM0_HUMAN | Thyroglobulin | TG | 901 | Annotation score: | ||
H0YBR7 | H0YBR7_HUMAN | Thyroglobulin | TG | 172 | Annotation score: | ||
H0YBC5 | H0YBC5_HUMAN | Thyroglobulin | TG | 62 | Annotation score: | ||
H0YBL4 | H0YBL4_HUMAN | Thyroglobulin | TG | 194 | Annotation score: | ||
H0YBQ6 | H0YBQ6_HUMAN | Thyroglobulin | TG | 74 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 – 25 | EYQ → GKF in CAA26527 (PubMed:2991855).Curated | 3 | |
Sequence conflicti | 848 | Missing AA sequence (PubMed:8615697).Curated | 1 | |
Sequence conflicti | 984 – 985 | EQ → DR in CAA29456 (PubMed:3681978).Curated | 2 | |
Sequence conflicti | 1359 – 1360 | Missing AA sequence (PubMed:8615697).Curated | 2 | |
Sequence conflicti | 1717 | L → A AA sequence (PubMed:8615697).Curated | 1 | |
Sequence conflicti | 1776 | T → S AA sequence (PubMed:8615697).Curated | 1 | |
Sequence conflicti | 2019 | G → H AA sequence (PubMed:8615697).Curated | 1 | |
Sequence conflicti | 2287 | F → P AA sequence (PubMed:8615697).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010212 | 135 | Q → H1 PublicationCorresponds to variant dbSNP:rs2069546Ensembl. | 1 | |
Natural variantiVAR_063034 | 183 | C → Y in TDH3. 1 Publication | 1 | |
Natural variantiVAR_016190 | 515 | Q → E1 PublicationCorresponds to variant dbSNP:rs180222EnsemblClinVar. | 1 | |
Natural variantiVAR_016852 | 604 | S → D Requires 2 nucleotide substitutions. 3 PublicationsCorresponds to variant dbSNP:rs2069547Ensembl. | 1 | |
Natural variantiVAR_016853 | 653 | G → D3 PublicationsCorresponds to variant dbSNP:rs2069548Ensembl. | 1 | |
Natural variantiVAR_010213 | 734 | S → A Associated with AITD3. 3 PublicationsCorresponds to variant dbSNP:rs180223EnsemblClinVar. | 1 | |
Natural variantiVAR_049077 | 777 | P → L. Corresponds to variant dbSNP:rs3739274EnsemblClinVar. | 1 | |
Natural variantiVAR_049078 | 815 | G → R. Corresponds to variant dbSNP:rs16904774EnsemblClinVar. | 1 | |
Natural variantiVAR_010214 | 830 | Q → E1 PublicationCorresponds to variant dbSNP:rs2076737Ensembl. | 1 | |
Natural variantiVAR_002365 | 870 | Q → H1 PublicationCorresponds to variant dbSNP:rs2229843EnsemblClinVar. | 1 | |
Natural variantiVAR_016854 | 985 | Missing 2 Publications | 1 | |
Natural variantiVAR_049079 | 988 | R → P. Corresponds to variant dbSNP:rs16893332EnsemblClinVar. | 1 | |
Natural variantiVAR_010215 | 1028 | M → V in AITD3; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs853326EnsemblClinVar. | 1 | |
Natural variantiVAR_016855 | 1043 | H → Y2 PublicationsCorresponds to variant dbSNP:rs143983705Ensembl. | 1 | |
Natural variantiVAR_016856 | 1059 | I → T2 PublicationsCorresponds to variant dbSNP:rs1016185504Ensembl. | 1 | |
Natural variantiVAR_049080 | 1063 | L → M. Corresponds to variant dbSNP:rs11992497EnsemblClinVar. | 1 | |
Natural variantiVAR_049081 | 1222 | S → L. Corresponds to variant dbSNP:rs12549018EnsemblClinVar. | 1 | |
Natural variantiVAR_010216 | 1264 | C → R in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076738Ensembl. | 1 | |
Natural variantiVAR_010217 | 1312 | D → G3 PublicationsCorresponds to variant dbSNP:rs2069556EnsemblClinVar. | 1 | |
Natural variantiVAR_016857 | 1437 | W → R2 PublicationsCorresponds to variant dbSNP:rs2069558Ensembl. | 1 | |
Natural variantiVAR_016858 | 1463 | P → H2 Publications | 1 | |
Natural variantiVAR_049082 | 1740 | T → K. Corresponds to variant dbSNP:rs16904791EnsemblClinVar. | 1 | |
Natural variantiVAR_010218 | 1838 | D → N1 PublicationCorresponds to variant dbSNP:rs2069561EnsemblClinVar. | 1 | |
Natural variantiVAR_063035 | 1897 | C → Y in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912649EnsemblClinVar. | 1 | |
Natural variantiVAR_016859 | 1936 | A → T2 PublicationsCorresponds to variant dbSNP:rs2069562Ensembl. | 1 | |
Natural variantiVAR_061173 | 1974 | M → T. Corresponds to variant dbSNP:rs56230101EnsemblClinVar. | 1 | |
Natural variantiVAR_010219 | 1996 | C → S in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076739EnsemblClinVar. | 1 | |
Natural variantiVAR_010220 | 1999 | R → W Benign variant. 2 PublicationsCorresponds to variant dbSNP:rs2076740EnsemblClinVar. | 1 | |
Natural variantiVAR_016860 | 2091 | D → E2 Publications | 1 | |
Natural variantiVAR_016861 | 2149 | P → L3 PublicationsCorresponds to variant dbSNP:rs2069564Ensembl. | 1 | |
Natural variantiVAR_016862 | 2170 | Q → R3 PublicationsCorresponds to variant dbSNP:rs2069565Ensembl. | 1 | |
Natural variantiVAR_063036 | 2234 | A → D in TDH3; reduces thyroglobulin synthesis and secretion; promotes thyroglobulin retention within the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs370991693Ensembl. | 1 | |
Natural variantiVAR_016863 | 2242 | R → H2 PublicationsCorresponds to variant dbSNP:rs2069566EnsemblClinVar. | 1 | |
Natural variantiVAR_078338 | 2336 – 2768 | Missing in TDH3; unknown pathological significance. 1 PublicationAdd BLAST | 433 | |
Natural variantiVAR_063037 | 2336 | R → Q in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912650EnsemblClinVar. | 1 | |
Natural variantiVAR_063038 | 2375 | G → R in TDH3. 1 PublicationCorresponds to variant dbSNP:rs137854434EnsemblClinVar. | 1 | |
Natural variantiVAR_049083 | 2455 | R → H. Corresponds to variant dbSNP:rs2272707EnsemblClinVar. | 1 | |
Natural variantiVAR_049084 | 2469 | L → P. Corresponds to variant dbSNP:rs2069568Ensembl. | 1 | |
Natural variantiVAR_010221 | 2501 | W → R1 PublicationCorresponds to variant dbSNP:rs2069569EnsemblClinVar. | 1 | |
Natural variantiVAR_049085 | 2526 | F → L. Corresponds to variant dbSNP:rs12114109EnsemblClinVar. | 1 | |
Natural variantiVAR_010222 | 2530 | R → Q1 PublicationCorresponds to variant dbSNP:rs1133076EnsemblClinVar. | 1 | |
Natural variantiVAR_049086 | 2616 | N → S. Corresponds to variant dbSNP:rs10091530EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012655 | 1510 – 1567 | CVTDC…SQCLM → L in isoform 2. 1 PublicationAdd BLAST | 58 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05615 mRNA Translation: CAA29104.1 U93033 mRNA Translation: AAC51924.1 AF230667 Genomic DNA No translation available. AF235100 Genomic DNA No translation available. AF230666 Genomic DNA No translation available. AF305872 Genomic DNA No translation available. X02154 mRNA Translation: CAA26089.1 X06059 , X06060, X06061, X06062, X06063, X06064, X06065, X06066 Genomic DNA Translation: CAA29454.1 X06067, X06068 Genomic DNA Translation: CAA29455.1 X06069, X06070 Genomic DNA Translation: CAA29456.1 X02749 Genomic DNA Translation: CAA26527.1 AH008122 Genomic DNA Translation: AAD51647.1 AH007064 Genomic DNA Translation: AAC95473.1 AF080484 , AF169654, AF169655, AF169656, AF169657, AF169658, AF169659, AF169661, AF169662, AF169663, AF169664, AF080472, AF080473, AF080474, AF080475, AF080476, AF080477, AF080478, AF080479, AF080480, AF080481, AF080482, AF080483 Genomic DNA Translation: AAD50912.2 S40807 mRNA Translation: AAB22685.1 |
CCDSi | CCDS34944.1 [P01266-1] |
PIRi | A59110, UIHU |
RefSeqi | NP_003226.4, NM_003235.4 [P01266-1] XP_016869284.1, XM_017013795.1 [P01266-2] |
Genome annotation databases
Ensembli | ENST00000220616; ENSP00000220616; ENSG00000042832 [P01266-1] |
GeneIDi | 7038 |
KEGGi | hsa:7038 |
UCSCi | uc003ytw.4, human [P01266-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Thyroglobulin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05615 mRNA Translation: CAA29104.1 U93033 mRNA Translation: AAC51924.1 AF230667 Genomic DNA No translation available. AF235100 Genomic DNA No translation available. AF230666 Genomic DNA No translation available. AF305872 Genomic DNA No translation available. X02154 mRNA Translation: CAA26089.1 X06059 , X06060, X06061, X06062, X06063, X06064, X06065, X06066 Genomic DNA Translation: CAA29454.1 X06067, X06068 Genomic DNA Translation: CAA29455.1 X06069, X06070 Genomic DNA Translation: CAA29456.1 X02749 Genomic DNA Translation: CAA26527.1 AH008122 Genomic DNA Translation: AAD51647.1 AH007064 Genomic DNA Translation: AAC95473.1 AF080484 , AF169654, AF169655, AF169656, AF169657, AF169658, AF169659, AF169661, AF169662, AF169663, AF169664, AF080472, AF080473, AF080474, AF080475, AF080476, AF080477, AF080478, AF080479, AF080480, AF080481, AF080482, AF080483 Genomic DNA Translation: AAD50912.2 S40807 mRNA Translation: AAB22685.1 |
CCDSi | CCDS34944.1 [P01266-1] |
PIRi | A59110, UIHU |
RefSeqi | NP_003226.4, NM_003235.4 [P01266-1] XP_016869284.1, XM_017013795.1 [P01266-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6SCJ | electron microscopy | 3.6 | A/B | 1-2768 | [»] | |
SMRi | P01266 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112896, 3 interactors |
ELMi | P01266 |
IntActi | P01266, 4 interactors |
STRINGi | 9606.ENSP00000220616 |
Chemistry databases
DrugBanki | DB05382, Iodine |
Protein family/group databases
ESTHERi | human-TG, Thyroglobulin |
MEROPSi | I31.950 |
PTM databases
CarbonylDBi | P01266 |
GlyConnecti | 600, 21 N-Linked glycans (1 site) |
GlyGeni | P01266, 18 sites |
iPTMneti | P01266 |
PhosphoSitePlusi | P01266 |
Genetic variation databases
BioMutai | TG |
DMDMi | 126302607 |
Proteomic databases
MassIVEi | P01266 |
PaxDbi | P01266 |
PeptideAtlasi | P01266 |
PRIDEi | P01266 |
ProteomicsDBi | 51364 [P01266-1] 51365 [P01266-2] |
Protocols and materials databases
ABCDi | P01266, 5 sequenced antibodies |
Antibodypediai | 860, 1762 antibodies |
Genome annotation databases
Ensembli | ENST00000220616; ENSP00000220616; ENSG00000042832 [P01266-1] |
GeneIDi | 7038 |
KEGGi | hsa:7038 |
UCSCi | uc003ytw.4, human [P01266-1] |
Organism-specific databases
CTDi | 7038 |
DisGeNETi | 7038 |
GeneCardsi | TG |
HGNCi | HGNC:11764, TG |
HPAi | ENSG00000042832, Tissue enriched (thyroid) |
MalaCardsi | TG |
MIMi | 188450, gene 274700, phenotype 608175, phenotype |
neXtProti | NX_P01266 |
OpenTargetsi | ENSG00000042832 |
Orphaneti | 95716, Familial thyroid dyshormonogenesis |
PharmGKBi | PA36479 |
VEuPathDBi | HostDB:ENSG00000042832.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1214, Eukaryota |
GeneTreei | ENSGT00940000159300 |
HOGENOMi | CLU_000943_0_0_1 |
InParanoidi | P01266 |
OMAi | DEQCIPC |
OrthoDBi | 754103at2759 |
PhylomeDBi | P01266 |
TreeFami | TF351833 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000042832-MONOMER |
PathwayCommonsi | P01266 |
SIGNORi | P01266 |
Miscellaneous databases
BioGRID-ORCSi | 7038, 2 hits in 875 CRISPR screens |
ChiTaRSi | TG, human |
GeneWikii | Thyroglobulin |
GenomeRNAii | 7038 |
Pharosi | P01266, Tbio |
PROi | PR:P01266 |
RNActi | P01266, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000042832, Expressed in thyroid gland and 128 other tissues |
ExpressionAtlasi | P01266, baseline and differential |
Genevisiblei | P01266, HS |
Family and domain databases
CDDi | cd00191, TY, 7 hits |
Gene3Di | 3.40.50.1820, 1 hit 4.10.800.10, 8 hits |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019819, Carboxylesterase_B_CS IPR016324, Thyroglobulin IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf IPR011641, Tyr-kin_ephrin_A/B_rcpt-like |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit PF07699, Ephrin_rec_like, 1 hit PF00086, Thyroglobulin_1, 10 hits |
PIRSFi | PIRSF001831, Thyroglobulin, 1 hit |
SMARTi | View protein in SMART SM01411, Ephrin_rec_like, 1 hit SM00211, TY, 10 hits |
SUPFAMi | SSF53474, SSF53474, 1 hit SSF57610, SSF57610, 11 hits |
PROSITEi | View protein in PROSITE PS00941, CARBOXYLESTERASE_B_2, 1 hit PS00484, THYROGLOBULIN_1_1, 9 hits PS51162, THYROGLOBULIN_1_2, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THYG_HUMAN | |
Accessioni | P01266Primary (citable) accession number: P01266 Secondary accession number(s): O15274 Q9UNY3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 219 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families