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UniProtKB - P01266 (THYG_HUMAN)

Protein

Thyroglobulin

Gene

TG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • hormone biosynthetic process Source: UniProtKB-KW
  • iodide transport Source: Ensembl
  • regulation of myelination Source: Ensembl
  • signal transduction Source: ProtInc
  • thyroid gland development Source: UniProtKB
  • thyroid hormone metabolic process Source: Ensembl
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processThyroid hormones biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000042832-MONOMER
SIGNORiP01266

Protein family/group databases

ESTHERihuman-TG Thyroglobulin
MEROPSiI31.950

Names & Taxonomyi

Protein namesi
Recommended name:
ThyroglobulinCurated
Short name:
Tg
Gene namesi
Name:TGImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000042832.11
HGNCiHGNC:11764 TG
MIMi188450 gene
neXtProtiNX_P01266

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Thyroid dyshormonogenesis 3 (TDH3)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
See also OMIM:274700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063034183C → Y in TDH3. 1 Publication1
Natural variantiVAR_0102161264C → R in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076738Ensembl.1
Natural variantiVAR_0630351897C → Y in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912649EnsemblClinVar.1
Natural variantiVAR_0102191996C → S in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076739EnsemblClinVar.1
Natural variantiVAR_0630362234A → D in TDH3; reduces thyroglobulin synthesis and secretion; promotes thyroglobulin retention within the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs370991693Ensembl.1
Natural variantiVAR_0783382336 – 2768Missing in TDH3; unknown pathological significance. 1 PublicationAdd BLAST433
Natural variantiVAR_0630372336R → Q in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912650EnsemblClinVar.1
Natural variantiVAR_0630382375G → R in TDH3. 1 PublicationCorresponds to variant dbSNP:rs137854434EnsemblClinVar.1
Autoimmune thyroid disease 3 (AITD3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA complex autoimmune disorder comprising two related diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2 differentiation and activate B-cells to produce antibodies against the TSH receptor, which stimulate the thyroid and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism.
See also OMIM:608175

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNETi7038
MalaCardsiTG
MIMi274700 phenotype
608175 phenotype
OpenTargetsiENSG00000042832
Orphaneti95716 Familial thyroid dyshormonogenesis
PharmGKBiPA36479

Polymorphism and mutation databases

BioMutaiTG
DMDMi126302607

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000000863620 – 2768ThyroglobulinAdd BLAST2749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Iodotyrosine; alternate1 Publication1
Modified residuei24Sulfotyrosine; alternateBy similarity1
Modified residuei24Thyroxine; alternate1 Publication1
Modified residuei24Triiodothyronine; alternate1 Publication1
Disulfide bondi34 ↔ 52PROSITE-ProRule annotation
Disulfide bondi63 ↔ 70PROSITE-ProRule annotation
Disulfide bondi72 ↔ 92PROSITE-ProRule annotation
Glycosylationi76N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi96 ↔ 120PROSITE-ProRule annotation
Disulfide bondi131 ↔ 138PROSITE-ProRule annotation
Disulfide bondi140 ↔ 160PROSITE-ProRule annotation
Modified residuei149Diiodotyrosine; alternate1 Publication1
Modified residuei149Iodotyrosine; alternate1 Publication1
Disulfide bondi164 ↔ 183PROSITE-ProRule annotation
Disulfide bondi194 ↔ 235PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei258Iodotyrosine1 Publication1
Disulfide bondi301 ↔ 319PROSITE-ProRule annotation
Disulfide bondi330 ↔ 336PROSITE-ProRule annotation
Disulfide bondi338 ↔ 358PROSITE-ProRule annotation
Glycosylationi484N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi529N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi608 ↔ 620PROSITE-ProRule annotation
Disulfide bondi631 ↔ 636PROSITE-ProRule annotation
Disulfide bondi638 ↔ 658PROSITE-ProRule annotation
Disulfide bondi662 ↔ 687PROSITE-ProRule annotation
Disulfide bondi698 ↔ 703PROSITE-ProRule annotation
Modified residuei704Diiodotyrosine; alternate1 Publication1
Modified residuei704Iodotyrosine; alternate1 Publication1
Modified residuei704Thyroxine; alternate1 Publication1
Modified residuei704Triiodothyronine; alternate1 Publication1
Disulfide bondi705 ↔ 726PROSITE-ProRule annotation
Disulfide bondi730 ↔ 763PROSITE-ProRule annotation
Glycosylationi748N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi774 ↔ 898PROSITE-ProRule annotation
Modified residuei785Iodotyrosine1 Publication1
Glycosylationi816N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei866Diiodotyrosine; alternate1 Publication1
Modified residuei866Iodotyrosine; alternate1 Publication1
Modified residuei883Diiodotyrosine1 Publication1
Disulfide bondi900 ↔ 921PROSITE-ProRule annotation
Glycosylationi947N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei992Diiodotyrosine; alternate1 Publication1
Modified residuei992Iodotyrosine; alternate1 Publication1
Disulfide bondi1042 ↔ 1049PROSITE-ProRule annotation
Disulfide bondi1051 ↔ 1073PROSITE-ProRule annotation
Disulfide bondi1077 ↔ 1108PROSITE-ProRule annotation
Disulfide bondi1126 ↔ 1145PROSITE-ProRule annotation
Disulfide bondi1149 ↔ 1169PROSITE-ProRule annotation
Disulfide bondi1181 ↔ 1188PROSITE-ProRule annotation
Disulfide bondi1190 ↔ 1210PROSITE-ProRule annotation
Glycosylationi1220N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei1310Iodotyrosine1 Publication1
Glycosylationi1348N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1349N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1365N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei1467Diiodotyrosine; alternate1 Publication1
Modified residuei1467Iodotyrosine; alternate1 Publication1
Disulfide bondi1514 ↔ 1523PROSITE-ProRule annotation
Disulfide bondi1543 ↔ 1565PROSITE-ProRule annotation
Glycosylationi1716N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1774N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2013N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei2184Iodotyrosine1 Publication1
Glycosylationi2250N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2264 ↔ 2281PROSITE-ProRule annotation
Glycosylationi2295N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei2573Diiodotyrosine; alternate1 Publication1
Modified residuei2573Iodotyrosine; alternate1 Publication1
Modified residuei2573Thyroxine; alternate1 Publication1
Modified residuei2573Triiodothyronine; alternate1 Publication1
Glycosylationi2582N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei2587Iodotyrosine1 Publication1
Modified residuei2617Iodotyrosine1 Publication1
Modified residuei2697Diiodotyrosine1 Publication1
Glycosylationi2749O-linked (Xyl...) (chondroitin sulfate) serine1 Publication1
Modified residuei2766Diiodotyrosine; alternate1 Publication1
Modified residuei2766Iodotyrosine; alternate1 Publication1
Modified residuei2766Thyroxine; alternate1 Publication1
Modified residuei2766Triiodothyronine; alternate1 Publication1

Post-translational modificationi

Sulfated tyrosines are desulfated during iodination.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei110Not glycosylated1 Publication1
Sitei496Not glycosylated1 Publication1
Sitei1869Not glycosylated1 Publication1
Sitei2122Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Iodination, Proteoglycan, Sulfation

Proteomic databases

PaxDbiP01266
PeptideAtlasiP01266
PRIDEiP01266
ProteomicsDBi51364
51365 [P01266-2]

PTM databases

CarbonylDBiP01266
GlyConnecti600
iPTMnetiP01266
PhosphoSitePlusiP01266
UniCarbKBiP01266

Expressioni

Tissue specificityi

Thyroid gland specific.

Gene expression databases

BgeeiENSG00000042832 Expressed in 103 organ(s), highest expression level in thyroid gland
ExpressionAtlasiP01266 baseline and differential
GenevisibleiP01266 HS

Organism-specific databases

HPAiCAB000077
CAB056155
HPA002740

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112896, 3 interactors
ELMiP01266
IntActiP01266, 2 interactors
STRINGi9606.ENSP00000220616

Structurei

3D structure databases

ProteinModelPortaliP01266
SMRiP01266
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 92Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST62
Domaini93 – 160Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST68
Domaini161 – 297Thyroglobulin type-1 3PROSITE-ProRule annotationAdd BLAST137
Domaini298 – 358Thyroglobulin type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini605 – 658Thyroglobulin type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini659 – 726Thyroglobulin type-1 6PROSITE-ProRule annotationAdd BLAST68
Domaini727 – 921Thyroglobulin type-1 7PROSITE-ProRule annotationAdd BLAST195
Domaini922 – 1073Thyroglobulin type-1 8PROSITE-ProRule annotationAdd BLAST152
Domaini1074 – 1145Thyroglobulin type-1 9PROSITE-ProRule annotationAdd BLAST72
Domaini1146 – 1210Thyroglobulin type-1 10PROSITE-ProRule annotationAdd BLAST65
Repeati1456 – 1469Type II1 PublicationAdd BLAST14
Repeati1470 – 1486Type II1 PublicationAdd BLAST17
Repeati1487 – 1503Type II1 PublicationAdd BLAST17
Domaini1511 – 1565Thyroglobulin type-1 11PROSITE-ProRule annotationAdd BLAST55
Repeati1603 – 1723Type IIIA1 PublicationAdd BLAST121
Repeati1724 – 1892Type IIIB1 PublicationAdd BLAST169
Repeati1893 – 1995Type IIIA1 PublicationAdd BLAST103
Repeati1996 – 2129Type IIIB1 PublicationAdd BLAST134
Repeati2130 – 2187Type IIIA1 PublicationAdd BLAST58

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IG6K Eukaryota
COG2272 LUCA
GeneTreeiENSGT00680000100015
HOVERGENiHBG017929
InParanoidiP01266
KOiK10809
OMAiLRSCWCV
OrthoDBiEOG091G004S
PhylomeDBiP01266
TreeFamiTF351833

Family and domain databases

CDDicd00191 TY, 7 hits
Gene3Di3.40.50.1820, 1 hit
4.10.800.10, 8 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR016324 Thyroglobulin
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00086 Thyroglobulin_1, 10 hits
PIRSFiPIRSF001831 Thyroglobulin, 1 hit
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00211 TY, 10 hits
SUPFAMiSSF53474 SSF53474, 1 hit
SSF57610 SSF57610, 11 hits
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 9 hits
PS51162 THYROGLOBULIN_1_2, 11 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P01266-1) [UniParc]FASTAAdd to basket
Also known as: Major

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVLEIFTL LASICWVSAN IFEYQVDAQP LRPCELQRET AFLKQADYVP 
        60         70         80         90        100
QCAEDGSFQT VQCQNDGRSC WCVGANGSEV LGSRQPGRPV ACLSFCQLQK 
       110        120        130        140        150
QQILLSGYIN STDTSYLPQC QDSGDYAPVQ CDVQQVQCWC VDAEGMEVYG 
       160        170        180        190        200
TRQLGRPKRC PRSCEIRNRR LLHGVGDKSP PQCSAEGEFM PVQCKFVNTT 
       210        220        230        240        250
DMMIFDLVHS YNRFPDAFVT FSSFQRRFPE VSGYCHCADS QGRELAETGL 
       260        270        280        290        300
ELLLDEIYDT IFAGLDLPST FTETTLYRIL QRRFLAVQSV ISGRFRCPTK 
       310        320        330        340        350
CEVERFTATS FGHPYVPSCR RNGDYQAVQC QTEGPCWCVD AQGKEMHGTR 
       360        370        380        390        400
QQGEPPSCAE GQSCASERQQ ALSRLYFGTS GYFSQHDLFS SPEKRWASPR 
       410        420        430        440        450
VARFATSCPP TIKELFVDSG LLRPMVEGQS QQFSVSENLL KEAIRAIFPS 
       460        470        480        490        500
RGLARLALQF TTNPKRLQQN LFGGKFLVNV GQFNLSGALG TRGTFNFSQF 
       510        520        530        540        550
FQQLGLASFL NGGRQEDLAK PLSVGLDSNS STGTPEAAKK DGTMNKPTVG 
       560        570        580        590        600
SFGFEINLQE NQNALKFLAS LLELPEFLLF LQHAISVPED VARDLGDVME 
       610        620        630        640        650
TVLSSQTCEQ TPERLFVPSC TTEGSYEDVQ CFSGECWCVN SWGKELPGSR 
       660        670        680        690        700
VRGGQPRCPT DCEKQRARMQ SLMGSQPAGS TLFVPACTSE GHFLPVQCFN 
       710        720        730        740        750
SECYCVDAEG QAIPGTRSAI GKPKKCPTPC QLQSEQAFLR TVQALLSNSS 
       760        770        780        790        800
MLPTLSDTYI PQCSTDGQWR QVQCNGPPEQ VFELYQRWEA QNKGQDLTPA 
       810        820        830        840        850
KLLVKIMSYR EAASGNFSLF IQSLYEAGQQ DVFPVLSQYP SLQDVPLAAL 
       860        870        880        890        900
EGKRPQPREN ILLEPYLFWQ ILNGQLSQYP GSYSDFSTPL AHFDLRNCWC 
       910        920        930        940        950
VDEAGQELEG MRSEPSKLPT CPGSCEEAKL RVLQFIRETE EIVSASNSSR 
       960        970        980        990       1000
FPLGESFLVA KGIRLRNEDL GLPPLFPPRE AFAEQFLRGS DYAIRLAAQS 
      1010       1020       1030       1040       1050
TLSFYQRRRF SPDDSAGASA LLRSGPYMPQ CDAFGSWEPV QCHAGTGHCW 
      1060       1070       1080       1090       1100
CVDEKGGFIP GSLTARSLQI PQCPTTCEKS RTSGLLSSWK QARSQENPSP 
      1110       1120       1130       1140       1150
KDLFVPACLE TGEYARLQAS GAGTWCVDPA SGEELRPGSS SSAQCPSLCN 
      1160       1170       1180       1190       1200
VLKSGVLSRR VSPGYVPACR AEDGGFSPVQ CDQAQGSCWC VMDSGEEVPG 
      1210       1220       1230       1240       1250
TRVTGGQPAC ESPRCPLPFN ASEVVGGTIL CETISGPTGS AMQQCQLLCR 
      1260       1270       1280       1290       1300
QGSWSVFPPG PLICSLESGR WESQLPQPRA CQRPQLWQTI QTQGHFQLQL 
      1310       1320       1330       1340       1350
PPGKMCSADY ADLLQTFQVF ILDELTARGF CQIQVKTFGT LVSIPVCNNS 
      1360       1370       1380       1390       1400
SVQVGCLTRE RLGVNVTWKS RLEDIPVASL PDLHDIERAL VGKDLLGRFT 
      1410       1420       1430       1440       1450
DLIQSGSFQL HLDSKTFPAE TIRFLQGDHF GTSPRTWFGC SEGFYQVLTS 
      1460       1470       1480       1490       1500
EASQDGLGCV KCPEGSYSQD EECIPCPVGF YQEQAGSLAC VPCPVGRTTI 
      1510       1520       1530       1540       1550
SAGAFSQTHC VTDCQRNEAG LQCDQNGQYR ASQKDRGSGK AFCVDGEGRR 
      1560       1570       1580       1590       1600
LPWWETEAPL EDSQCLMMQK FEKVPESKVI FDANAPVAVR SKVPDSEFPV 
      1610       1620       1630       1640       1650
MQCLTDCTED EACSFFTVST TEPEISCDFY AWTSDNVACM TSDQKRDALG 
      1660       1670       1680       1690       1700
NSKATSFGSL RCQVKVRSHG QDSPAVYLKK GQGSTTTLQK RFEPTGFQNM 
      1710       1720       1730       1740       1750
LSGLYNPIVF SASGANLTDA HLFCLLACDR DLCCDGFVLT QVQGGAIICG 
      1760       1770       1780       1790       1800
LLSSPSVLLC NVKDWMDPSE AWANATCPGV TYDQESHQVI LRLGDQEFIK 
      1810       1820       1830       1840       1850
SLTPLEGTQD TFTNFQQVYL WKDSDMGSRP ESMGCRKDTV PRPASPTEAG 
      1860       1870       1880       1890       1900
LTTELFSPVD LNQVIVNGNQ SLSSQKHWLF KHLFSAQQAN LWCLSRCVQE 
      1910       1920       1930       1940       1950
HSFCQLAEIT ESASLYFTCT LYPEAQVCDD IMESNAQGCR LILPQMPKAL 
      1960       1970       1980       1990       2000
FRKKVILEDK VKNFYTRLPF QKLMGISIRN KVPMSEKSIS NGFFECERRC 
      2010       2020       2030       2040       2050
DADPCCTGFG FLNVSQLKGG EVTCLTLNSL GIQMCSEENG GAWRILDCGS 
      2060       2070       2080       2090       2100
PDIEVHTYPF GWYQKPIAQN NAPSFCPLVV LPSLTEKVSL DSWQSLALSS 
      2110       2120       2130       2140       2150
VVVDPSIRHF DVAHVSTAAT SNFSAVRDLC LSECSQHEAC LITTLQTQPG 
      2160       2170       2180       2190       2200
AVRCMFYADT QSCTHSLQGQ NCRLLLREEA THIYRKPGIS LLSYEASVPS 
      2210       2220       2230       2240       2250
VPISTHGRLL GRSQAIQVGT SWKQVDQFLG VPYAAPPLAE RRFQAPEPLN 
      2260       2270       2280       2290       2300
WTGSWDASKP RASCWQPGTR TSTSPGVSED CLYLNVFIPQ NVAPNASVLV 
      2310       2320       2330       2340       2350
FFHNTMDREE SEGWPAIDGS FLAAVGNLIV VTASYRVGVF GFLSSGSGEV 
      2360       2370       2380       2390       2400
SGNWGLLDQV AALTWVQTHI RGFGGDPRRV SLAADRGGAD VASIHLLTAR 
      2410       2420       2430       2440       2450
ATNSQLFRRA VLMGGSALSP AAVISHERAQ QQAIALAKEV SCPMSSSQEV 
      2460       2470       2480       2490       2500
VSCLRQKPAN VLNDAQTKLL AVSGPFHYWG PVIDGHFLRE PPARALKRSL 
      2510       2520       2530       2540       2550
WVEVDLLIGS SQDDGLINRA KAVKQFEESR GRTSSKTAFY QALQNSLGGE 
      2560       2570       2580       2590       2600
DSDARVEAAA TWYYSLEHST DDYASFSRAL ENATRDYFII CPIIDMASAW 
      2610       2620       2630       2640       2650
AKRARGNVFM YHAPENYGHG SLELLADVQF ALGLPFYPAY EGQFSLEEKS 
      2660       2670       2680       2690       2700
LSLKIMQYFS HFIRSGNPNY PYEFSRKVPT FATPWPDFVP RAGGENYKEF 
      2710       2720       2730       2740       2750
SELLPNRQGL KKADCSFWSK YISSLKTSAD GAKGGQSAES EEEELTAGSG 
      2760 
LREDLLSLQE PGSKTYSK
Length:2,768
Mass (Da):304,790
Last modified:February 20, 2007 - v5
Checksum:i69A87D935F1BAA72
GO
Isoform 2 (identifier: P01266-2) [UniParc]FASTAAdd to basket
Also known as: Minor

The sequence of this isoform differs from the canonical sequence as follows:
     1510-1567: CVTDCQRNEAGLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWWETEAPLEDSQCLM → L

Show »
Length:2,711
Mass (Da):298,383
Checksum:iEEC6895F22D55EE0
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YB42H0YB42_HUMAN
Thyroglobulin
TG
147Annotation score:
H0YBJ2H0YBJ2_HUMAN
Thyroglobulin
TG
226Annotation score:
E5RG33E5RG33_HUMAN
Thyroglobulin
TG
59Annotation score:
H0YBY1H0YBY1_HUMAN
Thyroglobulin
TG
1,224Annotation score:
E7EVM0E7EVM0_HUMAN
Thyroglobulin
TG
901Annotation score:
H0YBL4H0YBL4_HUMAN
Thyroglobulin
TG
194Annotation score:
H0YBR7H0YBR7_HUMAN
Thyroglobulin
TG
172Annotation score:
H0YBQ6H0YBQ6_HUMAN
Thyroglobulin
TG
74Annotation score:
H0YBC5H0YBC5_HUMAN
Thyroglobulin
TG
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23 – 25EYQ → GKF in CAA26527 (PubMed:2991855).Curated3
Sequence conflicti848Missing AA sequence (PubMed:8615697).Curated1
Sequence conflicti984 – 985EQ → DR in CAA29456 (PubMed:3681978).Curated2
Sequence conflicti1359 – 1360Missing AA sequence (PubMed:8615697).Curated2
Sequence conflicti1717L → A AA sequence (PubMed:8615697).Curated1
Sequence conflicti1776T → S AA sequence (PubMed:8615697).Curated1
Sequence conflicti2019G → H AA sequence (PubMed:8615697).Curated1
Sequence conflicti2287F → P AA sequence (PubMed:8615697).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010212135Q → H1 PublicationCorresponds to variant dbSNP:rs2069546Ensembl.1
Natural variantiVAR_063034183C → Y in TDH3. 1 Publication1
Natural variantiVAR_016190515Q → E1 PublicationCorresponds to variant dbSNP:rs180222EnsemblClinVar.1
Natural variantiVAR_016852604S → D Requires 2 nucleotide substitutions. 3 PublicationsCorresponds to variant dbSNP:rs2069547Ensembl.1
Natural variantiVAR_016853653G → D3 PublicationsCorresponds to variant dbSNP:rs2069548Ensembl.1
Natural variantiVAR_010213734S → A Polymorphism associated with AITD3. 3 PublicationsCorresponds to variant dbSNP:rs180223EnsemblClinVar.1
Natural variantiVAR_049077777P → L. Corresponds to variant dbSNP:rs3739274EnsemblClinVar.1
Natural variantiVAR_049078815G → R. Corresponds to variant dbSNP:rs16904774EnsemblClinVar.1
Natural variantiVAR_010214830Q → E1 PublicationCorresponds to variant dbSNP:rs2076737Ensembl.1
Natural variantiVAR_002365870Q → H1 PublicationCorresponds to variant dbSNP:rs2229843EnsemblClinVar.1
Natural variantiVAR_016854985Missing 2 Publications1
Natural variantiVAR_049079988R → P. Corresponds to variant dbSNP:rs16893332EnsemblClinVar.1
Natural variantiVAR_0102151028M → V Polymorphism associated with AITD3. 2 PublicationsCorresponds to variant dbSNP:rs853326EnsemblClinVar.1
Natural variantiVAR_0168551043H → Y2 PublicationsCorresponds to variant dbSNP:rs143983705Ensembl.1
Natural variantiVAR_0168561059I → T2 PublicationsCorresponds to variant dbSNP:rs1016185504Ensembl.1
Natural variantiVAR_0490801063L → M. Corresponds to variant dbSNP:rs11992497EnsemblClinVar.1
Natural variantiVAR_0490811222S → L. Corresponds to variant dbSNP:rs12549018Ensembl.1
Natural variantiVAR_0102161264C → R in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076738Ensembl.1
Natural variantiVAR_0102171312D → G3 PublicationsCorresponds to variant dbSNP:rs2069556EnsemblClinVar.1
Natural variantiVAR_0168571437W → R2 PublicationsCorresponds to variant dbSNP:rs2069558Ensembl.1
Natural variantiVAR_0168581463P → H2 Publications1
Natural variantiVAR_0490821740T → K. Corresponds to variant dbSNP:rs16904791Ensembl.1
Natural variantiVAR_0102181838D → N1 PublicationCorresponds to variant dbSNP:rs2069561EnsemblClinVar.1
Natural variantiVAR_0630351897C → Y in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912649EnsemblClinVar.1
Natural variantiVAR_0168591936A → T2 PublicationsCorresponds to variant dbSNP:rs2069562Ensembl.1
Natural variantiVAR_0611731974M → T. Corresponds to variant dbSNP:rs56230101EnsemblClinVar.1
Natural variantiVAR_0320131979R → W Polymorphism associated with AITD3. 1 Publication1
Natural variantiVAR_0102191996C → S in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076739EnsemblClinVar.1
Natural variantiVAR_0102201999R → W1 PublicationCorresponds to variant dbSNP:rs2076740EnsemblClinVar.1
Natural variantiVAR_0168602091D → E2 Publications1
Natural variantiVAR_0168612149P → L3 PublicationsCorresponds to variant dbSNP:rs2069564Ensembl.1
Natural variantiVAR_0168622170Q → R3 PublicationsCorresponds to variant dbSNP:rs2069565Ensembl.1
Natural variantiVAR_0630362234A → D in TDH3; reduces thyroglobulin synthesis and secretion; promotes thyroglobulin retention within the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs370991693Ensembl.1
Natural variantiVAR_0168632242R → H2 PublicationsCorresponds to variant dbSNP:rs2069566EnsemblClinVar.1
Natural variantiVAR_0783382336 – 2768Missing in TDH3; unknown pathological significance. 1 PublicationAdd BLAST433
Natural variantiVAR_0630372336R → Q in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912650EnsemblClinVar.1
Natural variantiVAR_0630382375G → R in TDH3. 1 PublicationCorresponds to variant dbSNP:rs137854434EnsemblClinVar.1
Natural variantiVAR_0490832455R → H. Corresponds to variant dbSNP:rs2272707Ensembl.1
Natural variantiVAR_0490842469L → P. Corresponds to variant dbSNP:rs2069568Ensembl.1
Natural variantiVAR_0102212501W → R1 PublicationCorresponds to variant dbSNP:rs2069569EnsemblClinVar.1
Natural variantiVAR_0490852526F → L. Corresponds to variant dbSNP:rs12114109EnsemblClinVar.1
Natural variantiVAR_0102222530R → Q1 PublicationCorresponds to variant dbSNP:rs1133076EnsemblClinVar.1
Natural variantiVAR_0490862616N → S. Corresponds to variant dbSNP:rs10091530EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126551510 – 1567CVTDC…SQCLM → L in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05615 mRNA Translation: CAA29104.1
U93033 mRNA Translation: AAC51924.1
AF230667 Genomic DNA No translation available.
AF235100 Genomic DNA No translation available.
AF230666 Genomic DNA No translation available.
AF305872 Genomic DNA No translation available.
X02154 mRNA Translation: CAA26089.1
X06059
, X06060, X06061, X06062, X06063, X06064, X06065, X06066 Genomic DNA Translation: CAA29454.1
X06067, X06068 Genomic DNA Translation: CAA29455.1
X06069, X06070 Genomic DNA Translation: CAA29456.1
X02749 Genomic DNA Translation: CAA26527.1
AH008122 Genomic DNA Translation: AAD51647.1
AH007064 Genomic DNA Translation: AAC95473.1
AF080484
, AF169654, AF169655, AF169656, AF169657, AF169658, AF169659, AF169661, AF169662, AF169663, AF169664, AF080472, AF080473, AF080474, AF080475, AF080476, AF080477, AF080478, AF080479, AF080480, AF080481, AF080482, AF080483 Genomic DNA Translation: AAD50912.2
S40807 mRNA Translation: AAB22685.1
CCDSiCCDS34944.1 [P01266-1]
PIRiA59110 UIHU
RefSeqiNP_003226.4, NM_003235.4 [P01266-1]
XP_016869284.1, XM_017013795.1 [P01266-2]
UniGeneiHs.654591

Genome annotation databases

EnsembliENST00000220616; ENSP00000220616; ENSG00000042832 [P01266-1]
GeneIDi7038
KEGGihsa:7038
UCSCiuc003ytw.4 human [P01266-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Thyroglobulin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05615 mRNA Translation: CAA29104.1
U93033 mRNA Translation: AAC51924.1
AF230667 Genomic DNA No translation available.
AF235100 Genomic DNA No translation available.
AF230666 Genomic DNA No translation available.
AF305872 Genomic DNA No translation available.
X02154 mRNA Translation: CAA26089.1
X06059
, X06060, X06061, X06062, X06063, X06064, X06065, X06066 Genomic DNA Translation: CAA29454.1
X06067, X06068 Genomic DNA Translation: CAA29455.1
X06069, X06070 Genomic DNA Translation: CAA29456.1
X02749 Genomic DNA Translation: CAA26527.1
AH008122 Genomic DNA Translation: AAD51647.1
AH007064 Genomic DNA Translation: AAC95473.1
AF080484
, AF169654, AF169655, AF169656, AF169657, AF169658, AF169659, AF169661, AF169662, AF169663, AF169664, AF080472, AF080473, AF080474, AF080475, AF080476, AF080477, AF080478, AF080479, AF080480, AF080481, AF080482, AF080483 Genomic DNA Translation: AAD50912.2
S40807 mRNA Translation: AAB22685.1
CCDSiCCDS34944.1 [P01266-1]
PIRiA59110 UIHU
RefSeqiNP_003226.4, NM_003235.4 [P01266-1]
XP_016869284.1, XM_017013795.1 [P01266-2]
UniGeneiHs.654591

3D structure databases

ProteinModelPortaliP01266
SMRiP01266
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112896, 3 interactors
ELMiP01266
IntActiP01266, 2 interactors
STRINGi9606.ENSP00000220616

Protein family/group databases

ESTHERihuman-TG Thyroglobulin
MEROPSiI31.950

PTM databases

CarbonylDBiP01266
GlyConnecti600
iPTMnetiP01266
PhosphoSitePlusiP01266
UniCarbKBiP01266

Polymorphism and mutation databases

BioMutaiTG
DMDMi126302607

Proteomic databases

PaxDbiP01266
PeptideAtlasiP01266
PRIDEiP01266
ProteomicsDBi51364
51365 [P01266-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220616; ENSP00000220616; ENSG00000042832 [P01266-1]
GeneIDi7038
KEGGihsa:7038
UCSCiuc003ytw.4 human [P01266-1]

Organism-specific databases

CTDi7038
DisGeNETi7038
EuPathDBiHostDB:ENSG00000042832.11
GeneCardsiTG
H-InvDBiHIX0034371
HGNCiHGNC:11764 TG
HPAiCAB000077
CAB056155
HPA002740
MalaCardsiTG
MIMi188450 gene
274700 phenotype
608175 phenotype
neXtProtiNX_P01266
OpenTargetsiENSG00000042832
Orphaneti95716 Familial thyroid dyshormonogenesis
PharmGKBiPA36479
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6K Eukaryota
COG2272 LUCA
GeneTreeiENSGT00680000100015
HOVERGENiHBG017929
InParanoidiP01266
KOiK10809
OMAiLRSCWCV
OrthoDBiEOG091G004S
PhylomeDBiP01266
TreeFamiTF351833

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000042832-MONOMER
SIGNORiP01266

Miscellaneous databases

ChiTaRSiTG human
GeneWikiiThyroglobulin
GenomeRNAii7038
PROiPR:P01266
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000042832 Expressed in 103 organ(s), highest expression level in thyroid gland
ExpressionAtlasiP01266 baseline and differential
GenevisibleiP01266 HS

Family and domain databases

CDDicd00191 TY, 7 hits
Gene3Di3.40.50.1820, 1 hit
4.10.800.10, 8 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR016324 Thyroglobulin
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00086 Thyroglobulin_1, 10 hits
PIRSFiPIRSF001831 Thyroglobulin, 1 hit
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00211 TY, 10 hits
SUPFAMiSSF53474 SSF53474, 1 hit
SSF57610 SSF57610, 11 hits
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 9 hits
PS51162 THYROGLOBULIN_1_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTHYG_HUMAN
AccessioniPrimary (citable) accession number: P01266
Secondary accession number(s): O15274
, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 205 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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