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UniProtKB - P01266 (THYG_HUMAN)

Entry version 219 (10 Feb 2021)
Sequence version 5 (20 Feb 2007)
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Protein

Thyroglobulin

Gene

TG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030).2 Publications

Caution

The cholinesterase-like (ChEL) region lacks the Ser residue of the catalytic triad suggesting that it has no esterase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processThyroid hormones biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000042832-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01266

SIGNOR Signaling Network Open Resource

More...SIGNORi		P01266

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-TG, Thyroglobulin

MEROPS protease database

More...MEROPSi		I31.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ThyroglobulinCurated
Short name:
Tg
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TGImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11764, TG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		188450, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01266

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000042832.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Thyroid dyshormonogenesis 3 (TDH3)6 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063034183C → Y in TDH3. 1 Publication1
Natural variantiVAR_0102161264C → R in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076738Ensembl.1
Natural variantiVAR_0630351897C → Y in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912649EnsemblClinVar.1
Natural variantiVAR_0102191996C → S in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076739EnsemblClinVar.1
Natural variantiVAR_0630362234A → D in TDH3; reduces thyroglobulin synthesis and secretion; promotes thyroglobulin retention within the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs370991693Ensembl.1
Natural variantiVAR_0783382336 – 2768Missing in TDH3; unknown pathological significance. 1 PublicationAdd BLAST433
Natural variantiVAR_0630372336R → Q in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912650EnsemblClinVar.1
Natural variantiVAR_0630382375G → R in TDH3. 1 PublicationCorresponds to variant dbSNP:rs137854434EnsemblClinVar.1
Autoimmune thyroid disease 3 (AITD3)2 Publications
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA complex autoimmune disorder comprising two related diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2 differentiation and activate B-cells to produce antibodies against the TSH receptor, which stimulate the thyroid and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0102151028M → V in AITD3; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs853326EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24Y → F: Abolishes thyroxine (T4) production; when associated with F-1310, F-2573 and F-2766. 1 Publication1
Mutagenesisi108Y → F: Severe loss of thyroxine (T4) production; when associated with F-149 or F-234, and F-2540 and F-2766. Abolishes thyroxine (T4) production; when associated with F-149, F-234, F-2540 and F-2766. 1 Publication1
Mutagenesisi149Y → F: Severe loss of thyroxine (T4) production; when associated with F-108, F-2540 and F-2766. Abolishes thyroxine (T4) production; when associated with F-108, F-234, F-2540 and F-2766. 1 Publication1
Mutagenesisi234Y → F: Severe loss of thyroxine (T4) production; when associated with F-108, F-2540 and F-2766. Abolishes thyroxine (T4) production; when associated with F-108, F-149, F-2540 and F-2766. 1 Publication1
Mutagenesisi1309D → S: Abolishes thyroxine (T4) production. 1 Publication1
Mutagenesisi1310Y → F: Abolishes thyroxine (T4) production; when associated with F-24, F-2573 and F-2766. 1 Publication1
Mutagenesisi2540Y → F: Severe loss of thyroxine (T4) production; when associated with F-149 or F-234, and F-108 and F-2766. Abolishes thyroxine (T4) production; when associated with F-108, F-149, F-234 and F-2766. 1 Publication1
Mutagenesisi2573Y → F: Abolishes thyroxine (T4) production; when associated with F-24, F-1310 and F-2766. 1 Publication1
Mutagenesisi2766Y → F: Abolishes thyroxine (T4) production; when associated with F-24, F-1310 and F-2573. 1 Publication1
Mutagenesisi2766Y → F: Severe loss of thyroxine (T4) production; when associated with F-149 or F-234, and F-108 and F-2540. Abolishes thyroxine (T4) production; when associated with F-108, F-149, F-234 and F-2540. 1 Publication1

Keywords - Diseasei

Congenital hypothyroidism, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		7038

MalaCards human disease database

More...MalaCardsi		TG
MIMi274700, phenotype
608175, phenotype

Open Targets

More...OpenTargetsi		ENSG00000042832

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		95716, Familial thyroid dyshormonogenesis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36479

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01266, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB05382, Iodine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TG

Domain mapping of disease mutations (DMDM)

More...DMDMi		126302607

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000863620 – 2768ThyroglobulinAdd BLAST2749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24Iodotyrosine; alternate1 Publication1
Modified residuei24Sulfotyrosine; alternateBy similarity1
Modified residuei24Thyroxine; alternate1 Publication1 Publication1
Modified residuei24Triiodothyronine; alternate1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 52PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi63 ↔ 70PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi72 ↔ 92PROSITE-ProRule annotation1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi76N-linked (GlcNAc...) asparagine2 PublicationsImported1
Disulfide bondi96 ↔ 120PROSITE-ProRule annotation1 PublicationImported
Modified residuei108Iodotyrosine1 Publication1
Glycosylationi110N-linked (GlcNAc...) asparagine1 PublicationImported1
Disulfide bondi131 ↔ 138PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi140 ↔ 160PROSITE-ProRule annotation1 PublicationImported
Modified residuei149Diiodotyrosine; alternate1 Publication1
Modified residuei149Iodotyrosine; alternate1 Publication1 Publication1
Disulfide bondi164 ↔ 183PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi194 ↔ 235PROSITE-ProRule annotation1 PublicationImported
Glycosylationi198N-linked (GlcNAc...) asparagine2 PublicationsImported1
Modified residuei234Iodotyrosine1 Publication1
Disulfide bondi237 ↔ 2971 PublicationImported
Modified residuei258Iodotyrosine1 Publication1
Disulfide bondi301 ↔ 319PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi330 ↔ 336PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi338 ↔ 358PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi364 ↔ 6201 PublicationImported
Disulfide bondi408 ↔ 6081 PublicationImported
Glycosylationi484N-linked (GlcNAc...) asparagine2 PublicationsImported1
Glycosylationi529N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi631 ↔ 636PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi638 ↔ 658PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi662 ↔ 687PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi698 ↔ 703PROSITE-ProRule annotation1 PublicationImported
Modified residuei704Diiodotyrosine; alternate1 Publication1
Modified residuei704Iodotyrosine; alternate1 Publication1
Modified residuei704Thyroxine; alternate1 Publication1
Modified residuei704Triiodothyronine; alternate1 Publication1
Disulfide bondi705 ↔ 726PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi730 ↔ 763PROSITE-ProRule annotation1 PublicationImported
Glycosylationi748N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi774 ↔ 898PROSITE-ProRule annotation1 PublicationImported
Modified residuei785Iodotyrosine1 Publication1
Glycosylationi816N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei866Diiodotyrosine; alternate1 Publication1
Modified residuei866Iodotyrosine; alternate1 Publication1
Modified residuei883Diiodotyrosine1 Publication1
Disulfide bondi900 ↔ 921PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi925 ↔ 10311 PublicationImported
Glycosylationi947N-linked (GlcNAc...) asparagine2 PublicationsImported1
Modified residuei992Diiodotyrosine; alternate1 Publication1
Modified residuei992Iodotyrosine; alternate1 Publication1
Disulfide bondi1042 ↔ 1049PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1051 ↔ 1073PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1077 ↔ 1108PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1126 ↔ 1145PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1149 ↔ 1169PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1181 ↔ 1188PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1190 ↔ 1210PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1215 ↔ 12641 PublicationImported
Glycosylationi1220N-linked (GlcNAc...) asparagine2 PublicationsImported1
Disulfide bondi1231 ↔ 12451 PublicationImported
Disulfide bondi1306 ↔ 13561 PublicationImported
Modified residuei1310Iodotyrosine1 Publication1
Modified residuei1310Thyroxine1 Publication1 Publication1
Disulfide bondi1331 ↔ 13471 PublicationImported
Glycosylationi1348N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1349N-linked (GlcNAc...) asparagine2 PublicationsImported1
Glycosylationi1365N-linked (GlcNAc...) asparagine2 PublicationsImported1
Disulfide bondi1440 ↔ 14591 PublicationImported
Disulfide bondi1462 ↔ 14731 PublicationImported
Modified residuei1467Diiodotyrosine; alternate1 Publication1
Modified residuei1467Iodotyrosine; alternate1 Publication1
Disulfide bondi1476 ↔ 14901 PublicationImported
Disulfide bondi1493 ↔ 15101 PublicationImported
Disulfide bondi1514 ↔ 1523PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1543 ↔ 1565PROSITE-ProRule annotation1 PublicationImported
Disulfide bondi1603 ↔ 16271 PublicationImported
Disulfide bondi1607 ↔ 16131 PublicationImported
Disulfide bondi1639 ↔ 16621 PublicationImported
Glycosylationi1716N-linked (GlcNAc...) asparagine2 PublicationsImported1
Disulfide bondi1724 ↔ 17491 PublicationImported
Disulfide bondi1728 ↔ 17341 PublicationImported
Disulfide bondi1733 ↔ 18351 PublicationImported
Disulfide bondi1760 ↔ 17771 PublicationImported
Glycosylationi1774N-linked (GlcNAc...) asparagine2 PublicationsImported1
Glycosylationi1869N-linked (GlcNAc...) asparagine1 PublicationImported1
Disulfide bondi1893 ↔ 19191 PublicationImported
Disulfide bondi1897 ↔ 19041 PublicationImported
Disulfide bondi1928 ↔ 19391 PublicationImported
Disulfide bondi1996 ↔ 20241 PublicationImported
Disulfide bondi2000 ↔ 20061 PublicationImported
Disulfide bondi2005 ↔ 20761 PublicationImported
Glycosylationi2013N-linked (GlcNAc...) asparagine2 PublicationsImported1
Disulfide bondi2035 ↔ 20481 PublicationImported
Glycosylationi2122N-linked (GlcNAc...) asparagine1 PublicationImported1
Disulfide bondi2130 ↔ 21541 PublicationImported
Disulfide bondi2134 ↔ 21401 PublicationImported
Disulfide bondi2163 ↔ 21721 PublicationImported
Modified residuei2184Iodotyrosine1 Publication1
Glycosylationi2250N-linked (GlcNAc...) asparagine2 PublicationsImported1
Disulfide bondi2264 ↔ 2281PROSITE-ProRule annotation1 PublicationImported
Glycosylationi2295N-linked (GlcNAc...) asparagine2 PublicationsImported1
Disulfide bondi2442 ↔ 24531 PublicationImported
Modified residuei2540Iodotyrosine1 Publication1
Modified residuei2573Diiodotyrosine; alternate1 Publication1
Modified residuei2573Iodotyrosine; alternate1 Publication1
Modified residuei2573Thyroxine; alternate1 Publication1 Publication1
Modified residuei2573Triiodothyronine; alternate1 Publication1
Glycosylationi2582N-linked (GlcNAc...) asparagine2 PublicationsImported1
Modified residuei2587Iodotyrosine1 Publication1
Disulfide bondi2591 ↔ 27151 PublicationImported
Modified residuei2617Iodotyrosine1 Publication1
Modified residuei2697Diiodotyrosine1 Publication1
Glycosylationi2749O-linked (Xyl...) (chondroitin sulfate) serine1 Publication1
Modified residuei2766Diiodotyrosine; alternate1 Publication1
Modified residuei2766Iodotyrosine; alternate1 Publication1
Modified residuei2766Thyroxine; alternate1 Publication1 Publication1
Modified residuei2766Triiodothyronine; alternate1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Iodinated on tyrosine residues by TPO (PubMed:2760035, PubMed:32025030). There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2573 is coupled to donor Tyr-2540, acceptor Tyr-2766 in monomer 1 is coupled to donor Tyr-2766 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-108 in monomer 2 (PubMed:32025030).2 Publications
Sulfated tyrosines are desulfated during iodination.1 Publication
Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones. In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL. Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4. Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei110Not glycosylated1 Publication1
Sitei496Not glycosylated1 Publication1
Sitei1869Not glycosylated1 Publication1
Sitei2122Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Iodination, Proteoglycan, Sulfation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01266

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01266

PeptideAtlas

More...PeptideAtlasi		P01266

PRoteomics IDEntifications database

More...PRIDEi		P01266

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51364 [P01266-1]
51365 [P01266-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P01266

GlyConnect protein glycosylation platform

More...GlyConnecti		600, 21 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P01266, 18 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01266

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01266

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in the thyroid gland.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000042832, Expressed in thyroid gland and 128 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P01266, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01266, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000042832, Tissue enriched (thyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:32025030). Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus (PubMed:32025030). Homooligomer; disulfide-linked; stored in this form in the thyroid follicle lumen (PubMed:8626858).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112896, 3 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P01266

Protein interaction database and analysis system

More...IntActi		P01266, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000220616

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01266, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01266

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 92Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST62
Domaini93 – 160Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST68
Domaini161 – 297Thyroglobulin type-1 3PROSITE-ProRule annotationAdd BLAST137
Domaini298 – 358Thyroglobulin type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini605 – 658Thyroglobulin type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini659 – 726Thyroglobulin type-1 6PROSITE-ProRule annotationAdd BLAST68
Domaini727 – 921Thyroglobulin type-1 7PROSITE-ProRule annotationAdd BLAST195
Domaini922 – 1073Thyroglobulin type-1 8PROSITE-ProRule annotationAdd BLAST152
Domaini1074 – 1145Thyroglobulin type-1 9PROSITE-ProRule annotationAdd BLAST72
Domaini1146 – 1210Thyroglobulin type-1 10PROSITE-ProRule annotationAdd BLAST65
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1456 – 1469Type II1 PublicationAdd BLAST14
Repeati1470 – 1486Type II1 PublicationAdd BLAST17
Repeati1487 – 1503Type II1 PublicationAdd BLAST17
Domaini1511 – 1565Thyroglobulin type-1 11PROSITE-ProRule annotationAdd BLAST55
Repeati1603 – 1723Type IIIA1 PublicationAdd BLAST121
Repeati1724 – 1892Type IIIB1 PublicationAdd BLAST169
Repeati1893 – 1995Type IIIA1 PublicationAdd BLAST103
Repeati1996 – 2129Type IIIB1 PublicationAdd BLAST134
Repeati2130 – 2187Type IIIA1 PublicationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2188 – 2768Cholinesterase-like (ChEL)By similarityAdd BLAST581

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cholinesterase-like (ChEL) region is required for dimerization and export from the endoplasmic reticulum.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1214, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159300

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000943_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01266

Identification of Orthologs from Complete Genome Data

More...OMAi		DEQCIPC

Database of Orthologous Groups

More...OrthoDBi		754103at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01266

TreeFam database of animal gene trees

More...TreeFami		TF351833

Family and domain databases

Conserved Domains Database

More...CDDi		cd00191, TY, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit
4.10.800.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019819, Carboxylesterase_B_CS
IPR016324, Thyroglobulin
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00135, COesterase, 1 hit
PF07699, Ephrin_rec_like, 1 hit
PF00086, Thyroglobulin_1, 10 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001831, Thyroglobulin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01411, Ephrin_rec_like, 1 hit
SM00211, TY, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit
SSF57610, SSF57610, 11 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00941, CARBOXYLESTERASE_B_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 9 hits
PS51162, THYROGLOBULIN_1_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P01266-1) [UniParc]FASTAAdd to basket
Also known as: Major

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVLEIFTL LASICWVSAN IFEYQVDAQP LRPCELQRET AFLKQADYVP 
        60         70         80         90        100
QCAEDGSFQT VQCQNDGRSC WCVGANGSEV LGSRQPGRPV ACLSFCQLQK 
       110        120        130        140        150
QQILLSGYIN STDTSYLPQC QDSGDYAPVQ CDVQQVQCWC VDAEGMEVYG 
       160        170        180        190        200
TRQLGRPKRC PRSCEIRNRR LLHGVGDKSP PQCSAEGEFM PVQCKFVNTT 
       210        220        230        240        250
DMMIFDLVHS YNRFPDAFVT FSSFQRRFPE VSGYCHCADS QGRELAETGL 
       260        270        280        290        300
ELLLDEIYDT IFAGLDLPST FTETTLYRIL QRRFLAVQSV ISGRFRCPTK 
       310        320        330        340        350
CEVERFTATS FGHPYVPSCR RNGDYQAVQC QTEGPCWCVD AQGKEMHGTR 
       360        370        380        390        400
QQGEPPSCAE GQSCASERQQ ALSRLYFGTS GYFSQHDLFS SPEKRWASPR 
       410        420        430        440        450
VARFATSCPP TIKELFVDSG LLRPMVEGQS QQFSVSENLL KEAIRAIFPS 
       460        470        480        490        500
RGLARLALQF TTNPKRLQQN LFGGKFLVNV GQFNLSGALG TRGTFNFSQF 
       510        520        530        540        550
FQQLGLASFL NGGRQEDLAK PLSVGLDSNS STGTPEAAKK DGTMNKPTVG 
       560        570        580        590        600
SFGFEINLQE NQNALKFLAS LLELPEFLLF LQHAISVPED VARDLGDVME 
       610        620        630        640        650
TVLSSQTCEQ TPERLFVPSC TTEGSYEDVQ CFSGECWCVN SWGKELPGSR 
       660        670        680        690        700
VRGGQPRCPT DCEKQRARMQ SLMGSQPAGS TLFVPACTSE GHFLPVQCFN 
       710        720        730        740        750
SECYCVDAEG QAIPGTRSAI GKPKKCPTPC QLQSEQAFLR TVQALLSNSS 
       760        770        780        790        800
MLPTLSDTYI PQCSTDGQWR QVQCNGPPEQ VFELYQRWEA QNKGQDLTPA 
       810        820        830        840        850
KLLVKIMSYR EAASGNFSLF IQSLYEAGQQ DVFPVLSQYP SLQDVPLAAL 
       860        870        880        890        900
EGKRPQPREN ILLEPYLFWQ ILNGQLSQYP GSYSDFSTPL AHFDLRNCWC 
       910        920        930        940        950
VDEAGQELEG MRSEPSKLPT CPGSCEEAKL RVLQFIRETE EIVSASNSSR 
       960        970        980        990       1000
FPLGESFLVA KGIRLRNEDL GLPPLFPPRE AFAEQFLRGS DYAIRLAAQS 
      1010       1020       1030       1040       1050
TLSFYQRRRF SPDDSAGASA LLRSGPYMPQ CDAFGSWEPV QCHAGTGHCW 
      1060       1070       1080       1090       1100
CVDEKGGFIP GSLTARSLQI PQCPTTCEKS RTSGLLSSWK QARSQENPSP 
      1110       1120       1130       1140       1150
KDLFVPACLE TGEYARLQAS GAGTWCVDPA SGEELRPGSS SSAQCPSLCN 
      1160       1170       1180       1190       1200
VLKSGVLSRR VSPGYVPACR AEDGGFSPVQ CDQAQGSCWC VMDSGEEVPG 
      1210       1220       1230       1240       1250
TRVTGGQPAC ESPRCPLPFN ASEVVGGTIL CETISGPTGS AMQQCQLLCR 
      1260       1270       1280       1290       1300
QGSWSVFPPG PLICSLESGR WESQLPQPRA CQRPQLWQTI QTQGHFQLQL 
      1310       1320       1330       1340       1350
PPGKMCSADY ADLLQTFQVF ILDELTARGF CQIQVKTFGT LVSIPVCNNS 
      1360       1370       1380       1390       1400
SVQVGCLTRE RLGVNVTWKS RLEDIPVASL PDLHDIERAL VGKDLLGRFT 
      1410       1420       1430       1440       1450
DLIQSGSFQL HLDSKTFPAE TIRFLQGDHF GTSPRTWFGC SEGFYQVLTS 
      1460       1470       1480       1490       1500
EASQDGLGCV KCPEGSYSQD EECIPCPVGF YQEQAGSLAC VPCPVGRTTI 
      1510       1520       1530       1540       1550
SAGAFSQTHC VTDCQRNEAG LQCDQNGQYR ASQKDRGSGK AFCVDGEGRR 
      1560       1570       1580       1590       1600
LPWWETEAPL EDSQCLMMQK FEKVPESKVI FDANAPVAVR SKVPDSEFPV 
      1610       1620       1630       1640       1650
MQCLTDCTED EACSFFTVST TEPEISCDFY AWTSDNVACM TSDQKRDALG 
      1660       1670       1680       1690       1700
NSKATSFGSL RCQVKVRSHG QDSPAVYLKK GQGSTTTLQK RFEPTGFQNM 
      1710       1720       1730       1740       1750
LSGLYNPIVF SASGANLTDA HLFCLLACDR DLCCDGFVLT QVQGGAIICG 
      1760       1770       1780       1790       1800
LLSSPSVLLC NVKDWMDPSE AWANATCPGV TYDQESHQVI LRLGDQEFIK 
      1810       1820       1830       1840       1850
SLTPLEGTQD TFTNFQQVYL WKDSDMGSRP ESMGCRKDTV PRPASPTEAG 
      1860       1870       1880       1890       1900
LTTELFSPVD LNQVIVNGNQ SLSSQKHWLF KHLFSAQQAN LWCLSRCVQE 
      1910       1920       1930       1940       1950
HSFCQLAEIT ESASLYFTCT LYPEAQVCDD IMESNAQGCR LILPQMPKAL 
      1960       1970       1980       1990       2000
FRKKVILEDK VKNFYTRLPF QKLMGISIRN KVPMSEKSIS NGFFECERRC 
      2010       2020       2030       2040       2050
DADPCCTGFG FLNVSQLKGG EVTCLTLNSL GIQMCSEENG GAWRILDCGS 
      2060       2070       2080       2090       2100
PDIEVHTYPF GWYQKPIAQN NAPSFCPLVV LPSLTEKVSL DSWQSLALSS 
      2110       2120       2130       2140       2150
VVVDPSIRHF DVAHVSTAAT SNFSAVRDLC LSECSQHEAC LITTLQTQPG 
      2160       2170       2180       2190       2200
AVRCMFYADT QSCTHSLQGQ NCRLLLREEA THIYRKPGIS LLSYEASVPS 
      2210       2220       2230       2240       2250
VPISTHGRLL GRSQAIQVGT SWKQVDQFLG VPYAAPPLAE RRFQAPEPLN 
      2260       2270       2280       2290       2300
WTGSWDASKP RASCWQPGTR TSTSPGVSED CLYLNVFIPQ NVAPNASVLV 
      2310       2320       2330       2340       2350
FFHNTMDREE SEGWPAIDGS FLAAVGNLIV VTASYRVGVF GFLSSGSGEV 
      2360       2370       2380       2390       2400
SGNWGLLDQV AALTWVQTHI RGFGGDPRRV SLAADRGGAD VASIHLLTAR 
      2410       2420       2430       2440       2450
ATNSQLFRRA VLMGGSALSP AAVISHERAQ QQAIALAKEV SCPMSSSQEV 
      2460       2470       2480       2490       2500
VSCLRQKPAN VLNDAQTKLL AVSGPFHYWG PVIDGHFLRE PPARALKRSL 
      2510       2520       2530       2540       2550
WVEVDLLIGS SQDDGLINRA KAVKQFEESR GRTSSKTAFY QALQNSLGGE 
      2560       2570       2580       2590       2600
DSDARVEAAA TWYYSLEHST DDYASFSRAL ENATRDYFII CPIIDMASAW 
      2610       2620       2630       2640       2650
AKRARGNVFM YHAPENYGHG SLELLADVQF ALGLPFYPAY EGQFSLEEKS 
      2660       2670       2680       2690       2700
LSLKIMQYFS HFIRSGNPNY PYEFSRKVPT FATPWPDFVP RAGGENYKEF 
      2710       2720       2730       2740       2750
SELLPNRQGL KKADCSFWSK YISSLKTSAD GAKGGQSAES EEEELTAGSG 
      2760 
LREDLLSLQE PGSKTYSK
Length:2,768
Mass (Da):304,790
Last modified:February 20, 2007 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69A87D935F1BAA72
GO
Isoform 2 (identifier: P01266-2) [UniParc]FASTAAdd to basket
Also known as: Minor

The sequence of this isoform differs from the canonical sequence as follows:
     1510-1567: CVTDCQRNEAGLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWWETEAPLEDSQCLM → L

Show »
Length:2,711
Mass (Da):298,383
Checksum:iEEC6895F22D55EE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBJ2H0YBJ2_HUMAN
Thyroglobulin
TG
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB42H0YB42_HUMAN
Thyroglobulin
TG
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBY1H0YBY1_HUMAN
Thyroglobulin
TG
1,224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG33E5RG33_HUMAN
Thyroglobulin
TG
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVM0E7EVM0_HUMAN
Thyroglobulin
TG
901Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBR7H0YBR7_HUMAN
Thyroglobulin
TG
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBC5H0YBC5_HUMAN
Thyroglobulin
TG
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBL4H0YBL4_HUMAN
Thyroglobulin
TG
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBQ6H0YBQ6_HUMAN
Thyroglobulin
TG
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23 – 25EYQ → GKF in CAA26527 (PubMed:2991855).Curated3
Sequence conflicti848Missing AA sequence (PubMed:8615697).Curated1
Sequence conflicti984 – 985EQ → DR in CAA29456 (PubMed:3681978).Curated2
Sequence conflicti1359 – 1360Missing AA sequence (PubMed:8615697).Curated2
Sequence conflicti1717L → A AA sequence (PubMed:8615697).Curated1
Sequence conflicti1776T → S AA sequence (PubMed:8615697).Curated1
Sequence conflicti2019G → H AA sequence (PubMed:8615697).Curated1
Sequence conflicti2287F → P AA sequence (PubMed:8615697).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010212135Q → H1 PublicationCorresponds to variant dbSNP:rs2069546Ensembl.1
Natural variantiVAR_063034183C → Y in TDH3. 1 Publication1
Natural variantiVAR_016190515Q → E1 PublicationCorresponds to variant dbSNP:rs180222EnsemblClinVar.1
Natural variantiVAR_016852604S → D Requires 2 nucleotide substitutions. 3 PublicationsCorresponds to variant dbSNP:rs2069547Ensembl.1
Natural variantiVAR_016853653G → D3 PublicationsCorresponds to variant dbSNP:rs2069548Ensembl.1
Natural variantiVAR_010213734S → A Associated with AITD3. 3 PublicationsCorresponds to variant dbSNP:rs180223EnsemblClinVar.1
Natural variantiVAR_049077777P → L. Corresponds to variant dbSNP:rs3739274EnsemblClinVar.1
Natural variantiVAR_049078815G → R. Corresponds to variant dbSNP:rs16904774EnsemblClinVar.1
Natural variantiVAR_010214830Q → E1 PublicationCorresponds to variant dbSNP:rs2076737Ensembl.1
Natural variantiVAR_002365870Q → H1 PublicationCorresponds to variant dbSNP:rs2229843EnsemblClinVar.1
Natural variantiVAR_016854985Missing 2 Publications1
Natural variantiVAR_049079988R → P. Corresponds to variant dbSNP:rs16893332EnsemblClinVar.1
Natural variantiVAR_0102151028M → V in AITD3; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs853326EnsemblClinVar.1
Natural variantiVAR_0168551043H → Y2 PublicationsCorresponds to variant dbSNP:rs143983705Ensembl.1
Natural variantiVAR_0168561059I → T2 PublicationsCorresponds to variant dbSNP:rs1016185504Ensembl.1
Natural variantiVAR_0490801063L → M. Corresponds to variant dbSNP:rs11992497EnsemblClinVar.1
Natural variantiVAR_0490811222S → L. Corresponds to variant dbSNP:rs12549018EnsemblClinVar.1
Natural variantiVAR_0102161264C → R in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076738Ensembl.1
Natural variantiVAR_0102171312D → G3 PublicationsCorresponds to variant dbSNP:rs2069556EnsemblClinVar.1
Natural variantiVAR_0168571437W → R2 PublicationsCorresponds to variant dbSNP:rs2069558Ensembl.1
Natural variantiVAR_0168581463P → H2 Publications1
Natural variantiVAR_0490821740T → K. Corresponds to variant dbSNP:rs16904791EnsemblClinVar.1
Natural variantiVAR_0102181838D → N1 PublicationCorresponds to variant dbSNP:rs2069561EnsemblClinVar.1
Natural variantiVAR_0630351897C → Y in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912649EnsemblClinVar.1
Natural variantiVAR_0168591936A → T2 PublicationsCorresponds to variant dbSNP:rs2069562Ensembl.1
Natural variantiVAR_0611731974M → T. Corresponds to variant dbSNP:rs56230101EnsemblClinVar.1
Natural variantiVAR_0102191996C → S in TDH3; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs2076739EnsemblClinVar.1
Natural variantiVAR_0102201999R → W Benign variant. 2 PublicationsCorresponds to variant dbSNP:rs2076740EnsemblClinVar.1
Natural variantiVAR_0168602091D → E2 Publications1
Natural variantiVAR_0168612149P → L3 PublicationsCorresponds to variant dbSNP:rs2069564Ensembl.1
Natural variantiVAR_0168622170Q → R3 PublicationsCorresponds to variant dbSNP:rs2069565Ensembl.1
Natural variantiVAR_0630362234A → D in TDH3; reduces thyroglobulin synthesis and secretion; promotes thyroglobulin retention within the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs370991693Ensembl.1
Natural variantiVAR_0168632242R → H2 PublicationsCorresponds to variant dbSNP:rs2069566EnsemblClinVar.1
Natural variantiVAR_0783382336 – 2768Missing in TDH3; unknown pathological significance. 1 PublicationAdd BLAST433
Natural variantiVAR_0630372336R → Q in TDH3. 1 PublicationCorresponds to variant dbSNP:rs121912650EnsemblClinVar.1
Natural variantiVAR_0630382375G → R in TDH3. 1 PublicationCorresponds to variant dbSNP:rs137854434EnsemblClinVar.1
Natural variantiVAR_0490832455R → H. Corresponds to variant dbSNP:rs2272707EnsemblClinVar.1
Natural variantiVAR_0490842469L → P. Corresponds to variant dbSNP:rs2069568Ensembl.1
Natural variantiVAR_0102212501W → R1 PublicationCorresponds to variant dbSNP:rs2069569EnsemblClinVar.1
Natural variantiVAR_0490852526F → L. Corresponds to variant dbSNP:rs12114109EnsemblClinVar.1
Natural variantiVAR_0102222530R → Q1 PublicationCorresponds to variant dbSNP:rs1133076EnsemblClinVar.1
Natural variantiVAR_0490862616N → S. Corresponds to variant dbSNP:rs10091530EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0126551510 – 1567CVTDC…SQCLM → L in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X05615 mRNA Translation: CAA29104.1
U93033 mRNA Translation: AAC51924.1
AF230667 Genomic DNA No translation available.
AF235100 Genomic DNA No translation available.
AF230666 Genomic DNA No translation available.
AF305872 Genomic DNA No translation available.
X02154 mRNA Translation: CAA26089.1
X06059 X06066 Genomic DNA Translation: CAA29454.1
X06067, X06068 Genomic DNA Translation: CAA29455.1
X06069, X06070 Genomic DNA Translation: CAA29456.1
X02749 Genomic DNA Translation: CAA26527.1
AH008122 Genomic DNA Translation: AAD51647.1
AH007064 Genomic DNA Translation: AAC95473.1
AF080484 AF080483 Genomic DNA Translation: AAD50912.2
S40807 mRNA Translation: AAB22685.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34944.1 [P01266-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A59110, UIHU

NCBI Reference Sequences

More...RefSeqi		NP_003226.4, NM_003235.4 [P01266-1]
XP_016869284.1, XM_017013795.1 [P01266-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000220616; ENSP00000220616; ENSG00000042832 [P01266-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7038

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7038

UCSC genome browser

More...UCSCi		uc003ytw.4, human [P01266-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Thyroglobulin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05615 mRNA Translation: CAA29104.1
U93033 mRNA Translation: AAC51924.1
AF230667 Genomic DNA No translation available.
AF235100 Genomic DNA No translation available.
AF230666 Genomic DNA No translation available.
AF305872 Genomic DNA No translation available.
X02154 mRNA Translation: CAA26089.1
X06059 X06066 Genomic DNA Translation: CAA29454.1
X06067, X06068 Genomic DNA Translation: CAA29455.1
X06069, X06070 Genomic DNA Translation: CAA29456.1
X02749 Genomic DNA Translation: CAA26527.1
AH008122 Genomic DNA Translation: AAD51647.1
AH007064 Genomic DNA Translation: AAC95473.1
AF080484 AF080483 Genomic DNA Translation: AAD50912.2
S40807 mRNA Translation: AAB22685.1
CCDSiCCDS34944.1 [P01266-1]
PIRiA59110, UIHU
RefSeqiNP_003226.4, NM_003235.4 [P01266-1]
XP_016869284.1, XM_017013795.1 [P01266-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6SCJelectron microscopy3.6A/B1-2768[»]
SMRiP01266
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112896, 3 interactors
ELMiP01266
IntActiP01266, 4 interactors
STRINGi9606.ENSP00000220616

Chemistry databases

DrugBankiDB05382, Iodine

Protein family/group databases

ESTHERihuman-TG, Thyroglobulin
MEROPSiI31.950

PTM databases

CarbonylDBiP01266
GlyConnecti600, 21 N-Linked glycans (1 site)
GlyGeniP01266, 18 sites
iPTMnetiP01266
PhosphoSitePlusiP01266

Genetic variation databases

BioMutaiTG
DMDMi126302607

Proteomic databases

MassIVEiP01266
PaxDbiP01266
PeptideAtlasiP01266
PRIDEiP01266
ProteomicsDBi51364 [P01266-1]
51365 [P01266-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P01266, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		860, 1762 antibodies

Genome annotation databases

EnsembliENST00000220616; ENSP00000220616; ENSG00000042832 [P01266-1]
GeneIDi7038
KEGGihsa:7038
UCSCiuc003ytw.4, human [P01266-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7038
DisGeNETi7038

GeneCards: human genes, protein and diseases

More...GeneCardsi		TG
HGNCiHGNC:11764, TG
HPAiENSG00000042832, Tissue enriched (thyroid)
MalaCardsiTG
MIMi188450, gene
274700, phenotype
608175, phenotype
neXtProtiNX_P01266
OpenTargetsiENSG00000042832
Orphaneti95716, Familial thyroid dyshormonogenesis
PharmGKBiPA36479
VEuPathDBiHostDB:ENSG00000042832.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1214, Eukaryota
GeneTreeiENSGT00940000159300
HOGENOMiCLU_000943_0_0_1
InParanoidiP01266
OMAiDEQCIPC
OrthoDBi754103at2759
PhylomeDBiP01266
TreeFamiTF351833

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000042832-MONOMER
PathwayCommonsiP01266
SIGNORiP01266

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7038, 2 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TG, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Thyroglobulin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7038
PharosiP01266, Tbio

Protein Ontology

More...PROi		PR:P01266
RNActiP01266, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000042832, Expressed in thyroid gland and 128 other tissues
ExpressionAtlasiP01266, baseline and differential
GenevisibleiP01266, HS

Family and domain databases

CDDicd00191, TY, 7 hits
Gene3Di3.40.50.1820, 1 hit
4.10.800.10, 8 hits
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019819, Carboxylesterase_B_CS
IPR016324, Thyroglobulin
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00135, COesterase, 1 hit
PF07699, Ephrin_rec_like, 1 hit
PF00086, Thyroglobulin_1, 10 hits
PIRSFiPIRSF001831, Thyroglobulin, 1 hit
SMARTiView protein in SMART
SM01411, Ephrin_rec_like, 1 hit
SM00211, TY, 10 hits
SUPFAMiSSF53474, SSF53474, 1 hit
SSF57610, SSF57610, 11 hits
PROSITEiView protein in PROSITE
PS00941, CARBOXYLESTERASE_B_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 9 hits
PS51162, THYROGLOBULIN_1_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHYG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01266
Secondary accession number(s): O15274
, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 20, 2007
Last modified: February 10, 2021
This is version 219 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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