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Protein

Calcitonin

Gene

CALCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.

GO - Molecular functioni

  • calcitonin receptor binding Source: UniProtKB
  • hormone activity Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-977225 Amyloid fiber formation

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Cleaved into the following 2 chains:
Alternative name(s):
Calcitonin carboxyl-terminal peptide
Short name:
CCP
PDN-21
Gene namesi
Name:CALCA
Synonyms:CALC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110680.12
HGNCiHGNC:1437 CALCA
MIMi114130 gene
neXtProtiNX_P01258

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi796
OpenTargetsiENSG00000110680
PharmGKBiPA26029

Polymorphism and mutation databases

BioMutaiCYP2R1
DMDMi322510018

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000405026 – 82Add BLAST57
PeptideiPRO_000000405185 – 116Calcitonin1 PublicationAdd BLAST32
PeptideiPRO_0000004052121 – 141KatacalcinAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Disulfide bondi85 ↔ 911 Publication
Modified residuei116Proline amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP01258
PeptideAtlasiP01258
PRIDEiP01258
ProteomicsDBi51362
51363 [P01258-2]
TopDownProteomicsiP01258-1 [P01258-1]

PTM databases

iPTMnetiP01258
PhosphoSitePlusiP01258

Expressioni

Gene expression databases

BgeeiENSG00000110680 Expressed in 110 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_CALCA
ExpressionAtlasiP01258 baseline and differential
GenevisibleiP01258 HS

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107247, 11 interactors
IntActiP01258, 4 interactors
MINTiP01258
STRINGi9606.ENSP00000331746

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01258
SMRiP01258
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01258

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7S Eukaryota
ENOG4111KS6 LUCA
HOGENOMiHOG000038203
HOVERGENiHBG031362
InParanoidiP01258
KOiK12332
OrthoDBiEOG091G0RF5
PhylomeDBiP01258
TreeFamiTF333069

Family and domain databases

InterProiView protein in InterPro
IPR021118 Calcitonin
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00270 CALCITONINA
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P01258-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL
60 70 80 90 100
LAALVQDYVQ MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF
110 120 130 140
NKFHTFPQTA IGVGAPGKKR DMSSDLERDH RPHVSMPQNA N
Length:141
Mass (Da):15,467
Last modified:September 12, 2018 - v3
Checksum:i99622305DD8B286F
GO
Isoform 2 (identifier: P01258-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-141: VSMPQNAN → NHCPEESL

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:141
Mass (Da):15,535
Checksum:i421A4C481D831C29
GO
Isoform 3 (identifier: P06881-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P06881.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):13,899
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92M → I in AAA51913 (PubMed:3872459).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0252712G → R1 PublicationCorresponds to variant dbSNP:rs34587547Ensembl.1
Natural variantiVAR_01459257D → N. Corresponds to variant dbSNP:rs5239Ensembl.1
Natural variantiVAR_02527267E → K1 PublicationCorresponds to variant dbSNP:rs34164367Ensembl.1
Natural variantiVAR_01459376S → R1 PublicationCorresponds to variant dbSNP:rs5241Ensembl.1
Natural variantiVAR_025273123S → T1 PublicationCorresponds to variant dbSNP:rs34414857Ensembl.1
Natural variantiVAR_025274138Q → P1 PublicationCorresponds to variant dbSNP:rs13306224Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000709134 – 141VSMPQNAN → NHCPEESL in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00356 mRNA Translation: CAA25103.1
M12666, M12664, M12665 Genomic DNA Translation: AAA51913.1
M26095 mRNA Translation: AAA35501.1
X03662 mRNA Translation: CAA27299.1
M64486 mRNA Translation: AAA58403.1
DQ080435 Genomic DNA Translation: AAY68212.1
AC090835 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68468.1
BC069684 mRNA Translation: AAH69684.1
BC069704 mRNA Translation: AAH69704.1
BC069760 mRNA Translation: AAH69760.1
BC069778 mRNA Translation: AAH69778.1
BC093753 mRNA Translation: AAH93753.1
BC101599 mRNA Translation: AAI01600.1
BC143562 mRNA Translation: AAI43563.1
K03513 mRNA Translation: AAA52124.1
X02330 mRNA Translation: CAA26189.1
CCDSiCCDS7819.1 [P01258-1]
PIRiA41716
S07643 TCHU
RefSeqiNP_001029124.1, NM_001033952.2
NP_001732.1, NM_001741.2
XP_016873772.1, XM_017018283.1
XP_016873773.1, XM_017018284.1
UniGeneiHs.37058

Genome annotation databases

EnsembliENST00000331587; ENSP00000331746; ENSG00000110680 [P01258-1]
ENST00000396372; ENSP00000379657; ENSG00000110680 [P01258-1]
ENST00000469608; ENSP00000420618; ENSG00000110680 [P01258-2]
GeneIDi796
KEGGihsa:796
UCSCiuc001mlv.2 human [P01258-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Calcitonin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00356 mRNA Translation: CAA25103.1
M12666, M12664, M12665 Genomic DNA Translation: AAA51913.1
M26095 mRNA Translation: AAA35501.1
X03662 mRNA Translation: CAA27299.1
M64486 mRNA Translation: AAA58403.1
DQ080435 Genomic DNA Translation: AAY68212.1
AC090835 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68468.1
BC069684 mRNA Translation: AAH69684.1
BC069704 mRNA Translation: AAH69704.1
BC069760 mRNA Translation: AAH69760.1
BC069778 mRNA Translation: AAH69778.1
BC093753 mRNA Translation: AAH93753.1
BC101599 mRNA Translation: AAI01600.1
BC143562 mRNA Translation: AAI43563.1
K03513 mRNA Translation: AAA52124.1
X02330 mRNA Translation: CAA26189.1
CCDSiCCDS7819.1 [P01258-1]
PIRiA41716
S07643 TCHU
RefSeqiNP_001029124.1, NM_001033952.2
NP_001732.1, NM_001741.2
XP_016873772.1, XM_017018283.1
XP_016873773.1, XM_017018284.1
UniGeneiHs.37058

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JXZNMR-A85-116[»]
ProteinModelPortaliP01258
SMRiP01258
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107247, 11 interactors
IntActiP01258, 4 interactors
MINTiP01258
STRINGi9606.ENSP00000331746

PTM databases

iPTMnetiP01258
PhosphoSitePlusiP01258

Polymorphism and mutation databases

BioMutaiCYP2R1
DMDMi322510018

Proteomic databases

PaxDbiP01258
PeptideAtlasiP01258
PRIDEiP01258
ProteomicsDBi51362
51363 [P01258-2]
TopDownProteomicsiP01258-1 [P01258-1]

Protocols and materials databases

DNASUi796
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331587; ENSP00000331746; ENSG00000110680 [P01258-1]
ENST00000396372; ENSP00000379657; ENSG00000110680 [P01258-1]
ENST00000469608; ENSP00000420618; ENSG00000110680 [P01258-2]
GeneIDi796
KEGGihsa:796
UCSCiuc001mlv.2 human [P01258-1]

Organism-specific databases

CTDi796
DisGeNETi796
EuPathDBiHostDB:ENSG00000110680.12
GeneCardsiCALCA
HGNCiHGNC:1437 CALCA
MIMi114130 gene
neXtProtiNX_P01258
OpenTargetsiENSG00000110680
PharmGKBiPA26029
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7S Eukaryota
ENOG4111KS6 LUCA
HOGENOMiHOG000038203
HOVERGENiHBG031362
InParanoidiP01258
KOiK12332
OrthoDBiEOG091G0RF5
PhylomeDBiP01258
TreeFamiTF333069

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

EvolutionaryTraceiP01258
GeneWikiiCalcitonin
GenomeRNAii796
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110680 Expressed in 110 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_CALCA
ExpressionAtlasiP01258 baseline and differential
GenevisibleiP01258 HS

Family and domain databases

InterProiView protein in InterPro
IPR021118 Calcitonin
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00270 CALCITONINA
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCALC_HUMAN
AccessioniPrimary (citable) accession number: P01258
Secondary accession number(s): B7ZL39
, Q13935, Q13937, Q52LX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 12, 2018
Last modified: October 10, 2018
This is version 180 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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