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Protein

Calcitonin

Gene

CALCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcitonin receptor binding Source: UniProtKB
  • hormone activity Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-977225 Amyloid fiber formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcitonin
Cleaved into the following 2 chains:
Alternative name(s):
Calcitonin carboxyl-terminal peptide
Short name:
CCP
PDN-21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CALCA
Synonyms:CALC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110680.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1437 CALCA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
114130 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01258

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
796

Open Targets

More...
OpenTargetsi
ENSG00000110680

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26029

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP2R1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000405026 – 82Add BLAST57
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000405185 – 116Calcitonin1 PublicationAdd BLAST32
PeptideiPRO_0000004052121 – 141KatacalcinAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei43PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi85 ↔ 911 Publication
Modified residuei116Proline amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01258

PeptideAtlas

More...
PeptideAtlasi
P01258

PRoteomics IDEntifications database

More...
PRIDEi
P01258

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51362
51363 [P01258-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P01258-1 [P01258-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01258

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01258

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110680 Expressed in 110 organ(s), highest expression level in dorsal root ganglion

CleanEx database of gene expression profiles

More...
CleanExi
HS_CALCA

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01258 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01258 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107247, 11 interactors

Protein interaction database and analysis system

More...
IntActi
P01258, 4 interactors

Molecular INTeraction database

More...
MINTi
P01258

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331746

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P01258

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01258

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01258

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IX7S Eukaryota
ENOG4111KS6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162876

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038203

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG031362

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01258

KEGG Orthology (KO)

More...
KOi
K12332

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0RF5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01258

TreeFam database of animal gene trees

More...
TreeFami
TF333069

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021118 Calcitonin
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like

The PANTHER Classification System

More...
PANTHERi
PTHR10505 PTHR10505, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00270 CALCITONINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00113 CALCITONIN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00258 CALCITONIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P01258-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL
60 70 80 90 100
LAALVQDYVQ MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF
110 120 130 140
NKFHTFPQTA IGVGAPGKKR DMSSDLERDH RPHVSMPQNA N
Length:141
Mass (Da):15,467
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99622305DD8B286F
GO
Isoform 2 (identifier: P01258-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-141: VSMPQNAN → NHCPEESL

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:141
Mass (Da):15,535
Checksum:i421A4C481D831C29
GO
Isoform 3 (identifier: P06881-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P06881.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):13,899
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92M → I in AAA51913 (PubMed:3872459).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0252712G → R1 PublicationCorresponds to variant dbSNP:rs34587547Ensembl.1
Natural variantiVAR_01459257D → N. Corresponds to variant dbSNP:rs5239Ensembl.1
Natural variantiVAR_02527267E → K1 PublicationCorresponds to variant dbSNP:rs34164367Ensembl.1
Natural variantiVAR_01459376S → R1 PublicationCorresponds to variant dbSNP:rs5241Ensembl.1
Natural variantiVAR_025273123S → T1 PublicationCorresponds to variant dbSNP:rs34414857Ensembl.1
Natural variantiVAR_025274138Q → P1 PublicationCorresponds to variant dbSNP:rs13306224Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000709134 – 141VSMPQNAN → NHCPEESL in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X00356 mRNA Translation: CAA25103.1
M12666, M12664, M12665 Genomic DNA Translation: AAA51913.1
M26095 mRNA Translation: AAA35501.1
X03662 mRNA Translation: CAA27299.1
M64486 mRNA Translation: AAA58403.1
DQ080435 Genomic DNA Translation: AAY68212.1
AC090835 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68468.1
BC069684 mRNA Translation: AAH69684.1
BC069704 mRNA Translation: AAH69704.1
BC069760 mRNA Translation: AAH69760.1
BC069778 mRNA Translation: AAH69778.1
BC093753 mRNA Translation: AAH93753.1
BC101599 mRNA Translation: AAI01600.1
BC143562 mRNA Translation: AAI43563.1
K03513 mRNA Translation: AAA52124.1
X02330 mRNA Translation: CAA26189.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7819.1 [P01258-1]

Protein sequence database of the Protein Information Resource

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PIRi
A41716
S07643 TCHU

NCBI Reference Sequences

More...
RefSeqi
NP_001029124.1, NM_001033952.2 [P01258-1]
NP_001732.1, NM_001741.2 [P01258-1]
XP_016873772.1, XM_017018283.1 [P01258-1]
XP_016873773.1, XM_017018284.1 [P01258-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.37058

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331587; ENSP00000331746; ENSG00000110680 [P01258-1]
ENST00000396372; ENSP00000379657; ENSG00000110680 [P01258-1]
ENST00000469608; ENSP00000420618; ENSG00000110680 [P01258-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
796

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:796

UCSC genome browser

More...
UCSCi
uc001mlv.2 human [P01258-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Calcitonin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00356 mRNA Translation: CAA25103.1
M12666, M12664, M12665 Genomic DNA Translation: AAA51913.1
M26095 mRNA Translation: AAA35501.1
X03662 mRNA Translation: CAA27299.1
M64486 mRNA Translation: AAA58403.1
DQ080435 Genomic DNA Translation: AAY68212.1
AC090835 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68468.1
BC069684 mRNA Translation: AAH69684.1
BC069704 mRNA Translation: AAH69704.1
BC069760 mRNA Translation: AAH69760.1
BC069778 mRNA Translation: AAH69778.1
BC093753 mRNA Translation: AAH93753.1
BC101599 mRNA Translation: AAI01600.1
BC143562 mRNA Translation: AAI43563.1
K03513 mRNA Translation: AAA52124.1
X02330 mRNA Translation: CAA26189.1
CCDSiCCDS7819.1 [P01258-1]
PIRiA41716
S07643 TCHU
RefSeqiNP_001029124.1, NM_001033952.2 [P01258-1]
NP_001732.1, NM_001741.2 [P01258-1]
XP_016873772.1, XM_017018283.1 [P01258-1]
XP_016873773.1, XM_017018284.1 [P01258-1]
UniGeneiHs.37058

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JXZNMR-A85-116[»]
ProteinModelPortaliP01258
SMRiP01258
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107247, 11 interactors
IntActiP01258, 4 interactors
MINTiP01258
STRINGi9606.ENSP00000331746

PTM databases

iPTMnetiP01258
PhosphoSitePlusiP01258

Polymorphism and mutation databases

BioMutaiCYP2R1
DMDMi322510018

Proteomic databases

PaxDbiP01258
PeptideAtlasiP01258
PRIDEiP01258
ProteomicsDBi51362
51363 [P01258-2]
TopDownProteomicsiP01258-1 [P01258-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
796
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331587; ENSP00000331746; ENSG00000110680 [P01258-1]
ENST00000396372; ENSP00000379657; ENSG00000110680 [P01258-1]
ENST00000469608; ENSP00000420618; ENSG00000110680 [P01258-2]
GeneIDi796
KEGGihsa:796
UCSCiuc001mlv.2 human [P01258-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
796
DisGeNETi796
EuPathDBiHostDB:ENSG00000110680.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CALCA
HGNCiHGNC:1437 CALCA
MIMi114130 gene
neXtProtiNX_P01258
OpenTargetsiENSG00000110680
PharmGKBiPA26029

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IX7S Eukaryota
ENOG4111KS6 LUCA
GeneTreeiENSGT00940000162876
HOGENOMiHOG000038203
HOVERGENiHBG031362
InParanoidiP01258
KOiK12332
OrthoDBiEOG091G0RF5
PhylomeDBiP01258
TreeFamiTF333069

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

EvolutionaryTraceiP01258

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Calcitonin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
796

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110680 Expressed in 110 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_CALCA
ExpressionAtlasiP01258 baseline and differential
GenevisibleiP01258 HS

Family and domain databases

InterProiView protein in InterPro
IPR021118 Calcitonin
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00270 CALCITONINA
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCALC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01258
Secondary accession number(s): B7ZL39
, Q13935, Q13937, Q52LX7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 12, 2018
Last modified: December 5, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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