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Protein

Growth hormone variant

Gene

GH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • growth hormone receptor binding Source: GO_Central
  • hormone activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1170546 Prolactin receptor signaling
R-HSA-982772 Growth hormone receptor signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01242

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth hormone variant
Short name:
GH-V
Alternative name(s):
Growth hormone 2
Placenta-specific growth hormone
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136487.17

Human Gene Nomenclature Database

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HGNCi
HGNC:4262 GH2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
139240 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P01242

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2689

Open Targets

More...
OpenTargetsi
ENSG00000136487

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28672

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GH2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003306127 – 217Growth hormone variantAdd BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi79 ↔ 191By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei176PhosphoserineBy similarity1
Disulfide bondi208 ↔ 215By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P01242

PeptideAtlas

More...
PeptideAtlasi
P01242

PRoteomics IDEntifications database

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PRIDEi
P01242

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51357
51358 [P01242-2]
51359 [P01242-3]
51360 [P01242-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01242

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01242

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136487 Expressed in 38 organ(s), highest expression level in chorionic villus

CleanEx database of gene expression profiles

More...
CleanExi
HS_GH2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P01242 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P01242 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043715

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108956, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333157

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01242

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01242

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00730000111012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000068443

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG011318

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01242

KEGG Orthology (KO)

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KOi
K05438

Identification of Orthologs from Complete Genome Data

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OMAi
TTMTHCS

Database of Orthologous Groups

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OrthoDBi
1190548at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P01242

TreeFam database of animal gene trees

More...
TreeFami
TF332592

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11417 PTHR11417, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00103 Hormone_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00836 SOMATOTROPIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P01242-1) [UniParc]FASTAAdd to basket
Also known as: GH-V1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGSRTSLL LAFGLLCLSW LQEGSAFPTI PLSRLFDNAM LRARRLYQLA
60 70 80 90 100
YDTYQEFEEA YILKEQKYSF LQNPQTSLCF SESIPTPSNR VKTQQKSNLE
110 120 130 140 150
LLRISLLLIQ SWLEPVQLLR SVFANSLVYG ASDSNVYRHL KDLEEGIQTL
160 170 180 190 200
MWRLEDGSPR TGQIFNQSYS KFDTKSHNDD ALLKNYGLLY CFRKDMDKVE
210
TFLRIVQCRS VEGSCGF
Length:217
Mass (Da):25,000
Last modified:March 27, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B9324698E822F96
GO
Isoform 2 (identifier: P01242-2) [UniParc]FASTAAdd to basket
Also known as: GH-V2

The sequence of this isoform differs from the canonical sequence as follows:
     153-217: RLEDGSPRTG...CRSVEGSCGF → VRVAPGIPNP...ADLQSVLQQV

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,875
Checksum:i5D1C10B75BA49EC6
GO
Isoform 3 (identifier: P01242-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-72: Missing.

Show »
Length:202
Mass (Da):23,128
Checksum:i38B64D011A9197C6
GO
Isoform 4 (identifier: P01242-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-217: MWRLEDGSPR...CRSVEGSCGF → IGWKMAAPGL...VLLQCPPALS

Note: No experimental confirmation available.
Show »
Length:245
Mass (Da):27,101
Checksum:i14CC7F8CD75D91C8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXJ5A0A087WXJ5_HUMAN
Growth hormone variant
GH2
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44Missing AA sequence (PubMed:2196278).Curated1
Sequence conflicti109I → T in AAB59547 (PubMed:3379057).Curated1
Sequence conflicti109I → T in AAB59548 (PubMed:3379057).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01459190R → W. Corresponds to variant dbSNP:rs5389Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04320658 – 72Missing in isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_043480151 – 217MWRLE…GSCGF → IGWKMAAPGLGRSSISPTAS LTQNRTTMTHCSRTTGCSTA SGRTWTRSRHSCASCSAALW RAAVASSCPGGIPVTPPQCL SWSWKVLLQCPPALS in isoform 4. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_006203153 – 217RLEDG…GSCGF → VRVAPGIPNPGAPLASRDWG EKHCCPLFSSQALTQENSPY SSFPLVNPPGLSLQPGGEGG KWMNERGREQCPSAWPLLLF LHFAEAGRWQPPDWADLQSV LQQV in isoform 2. 2 PublicationsAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K00470 Genomic DNA Translation: AAA98619.1
J03756 mRNA Translation: AAB59547.1
J03756 mRNA Translation: AAB59548.1
M38451 mRNA Translation: AAA35891.1
J03071 Genomic DNA Translation: AAA52552.1
AF006060 mRNA Translation: AAB71828.1
AF006061 mRNA Translation: AAB71829.1
EU421715 Genomic DNA Translation: ABZ88719.1
EU421715 Genomic DNA Translation: ABZ88720.1
EU421715 Genomic DNA Translation: ABZ88721.1
EU421715 Genomic DNA Translation: ABZ88722.1
AK312194 mRNA Translation: BAG35127.1
AB451332 mRNA Translation: BAG70146.1
AB451477 mRNA Translation: BAG70291.1
AC040958 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94238.1
CH471109 Genomic DNA Translation: EAW94248.1
CH471109 Genomic DNA Translation: EAW94252.1
CH471109 Genomic DNA Translation: EAW94258.1
BC020760 mRNA Translation: AAH20760.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11647.1 [P01242-1]
CCDS11648.1 [P01242-2]
CCDS45757.1 [P01242-4]
CCDS45758.1 [P01242-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A28072 STHUV2
D32435 STHUV

NCBI Reference Sequences

More...
RefSeqi
NP_002050.1, NM_002059.4 [P01242-1]
NP_072050.1, NM_022556.3 [P01242-3]
NP_072051.1, NM_022557.3 [P01242-2]
NP_072052.1, NM_022558.3 [P01242-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.406754
Hs.654390

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332800; ENSP00000333157; ENSG00000136487 [P01242-2]
ENST00000423893; ENSP00000409294; ENSG00000136487 [P01242-1]
ENST00000449787; ENSP00000410618; ENSG00000136487 [P01242-3]
ENST00000456543; ENSP00000394122; ENSG00000136487 [P01242-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2689

UCSC genome browser

More...
UCSCi
uc002jcl.3 human [P01242-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00470 Genomic DNA Translation: AAA98619.1
J03756 mRNA Translation: AAB59547.1
J03756 mRNA Translation: AAB59548.1
M38451 mRNA Translation: AAA35891.1
J03071 Genomic DNA Translation: AAA52552.1
AF006060 mRNA Translation: AAB71828.1
AF006061 mRNA Translation: AAB71829.1
EU421715 Genomic DNA Translation: ABZ88719.1
EU421715 Genomic DNA Translation: ABZ88720.1
EU421715 Genomic DNA Translation: ABZ88721.1
EU421715 Genomic DNA Translation: ABZ88722.1
AK312194 mRNA Translation: BAG35127.1
AB451332 mRNA Translation: BAG70146.1
AB451477 mRNA Translation: BAG70291.1
AC040958 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94238.1
CH471109 Genomic DNA Translation: EAW94248.1
CH471109 Genomic DNA Translation: EAW94252.1
CH471109 Genomic DNA Translation: EAW94258.1
BC020760 mRNA Translation: AAH20760.1
CCDSiCCDS11647.1 [P01242-1]
CCDS11648.1 [P01242-2]
CCDS45757.1 [P01242-4]
CCDS45758.1 [P01242-3]
PIRiA28072 STHUV2
D32435 STHUV
RefSeqiNP_002050.1, NM_002059.4 [P01242-1]
NP_072050.1, NM_022556.3 [P01242-3]
NP_072051.1, NM_022557.3 [P01242-2]
NP_072052.1, NM_022558.3 [P01242-4]
UniGeneiHs.406754
Hs.654390

3D structure databases

ProteinModelPortaliP01242
SMRiP01242
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108956, 2 interactors
STRINGi9606.ENSP00000333157

PTM databases

iPTMnetiP01242
PhosphoSitePlusiP01242

Polymorphism and mutation databases

BioMutaiGH2

Proteomic databases

PaxDbiP01242
PeptideAtlasiP01242
PRIDEiP01242
ProteomicsDBi51357
51358 [P01242-2]
51359 [P01242-3]
51360 [P01242-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2689
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332800; ENSP00000333157; ENSG00000136487 [P01242-2]
ENST00000423893; ENSP00000409294; ENSG00000136487 [P01242-1]
ENST00000449787; ENSP00000410618; ENSG00000136487 [P01242-3]
ENST00000456543; ENSP00000394122; ENSG00000136487 [P01242-4]
GeneIDi2689
KEGGihsa:2689
UCSCiuc002jcl.3 human [P01242-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2689
DisGeNETi2689
EuPathDBiHostDB:ENSG00000136487.17

GeneCards: human genes, protein and diseases

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GeneCardsi
GH2
HGNCiHGNC:4262 GH2
HPAiHPA043715
MIMi139240 gene
neXtProtiNX_P01242
OpenTargetsiENSG00000136487
PharmGKBiPA28672

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00730000111012
HOGENOMiHOG000068443
HOVERGENiHBG011318
InParanoidiP01242
KOiK05438
OMAiTTMTHCS
OrthoDBi1190548at2759
PhylomeDBiP01242
TreeFamiTF332592

Enzyme and pathway databases

ReactomeiR-HSA-1170546 Prolactin receptor signaling
R-HSA-982772 Growth hormone receptor signaling
SIGNORiP01242

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GH2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Growth_hormone_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2689

Protein Ontology

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PROi
PR:P01242

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136487 Expressed in 38 organ(s), highest expression level in chorionic villus
CleanExiHS_GH2
ExpressionAtlasiP01242 baseline and differential
GenevisibleiP01242 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01242
Secondary accession number(s): B1A4H5
, B1A4H7, O14643, O14644, P09587
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 27, 2002
Last modified: January 16, 2019
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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