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Protein

Growth hormone variant

Gene

GH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • growth hormone receptor binding Source: GO_Central
  • hormone activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-1170546 Prolactin receptor signaling
R-HSA-982772 Growth hormone receptor signaling
SIGNORiP01242

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone variant
Short name:
GH-V
Alternative name(s):
Growth hormone 2
Placenta-specific growth hormone
Gene namesi
Name:GH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000136487.17
HGNCiHGNC:4262 GH2
MIMi139240 gene
neXtProtiNX_P01242

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2689
OpenTargetsiENSG00000136487
PharmGKBiPA28672

Polymorphism and mutation databases

BioMutaiGH2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000003306127 – 217Growth hormone variantAdd BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 191By similarity
Modified residuei132PhosphoserineBy similarity1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei176PhosphoserineBy similarity1
Disulfide bondi208 ↔ 215By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01242
PeptideAtlasiP01242
PRIDEiP01242
ProteomicsDBi51357
51358 [P01242-2]
51359 [P01242-3]
51360 [P01242-4]

PTM databases

iPTMnetiP01242
PhosphoSitePlusiP01242

Expressioni

Tissue specificityi

Expressed in the placenta.

Gene expression databases

BgeeiENSG00000136487 Expressed in 38 organ(s), highest expression level in chorionic villus
CleanExiHS_GH2
ExpressionAtlasiP01242 baseline and differential
GenevisibleiP01242 HS

Organism-specific databases

HPAiHPA043715

Interactioni

Subunit structurei

Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108956, 2 interactors
STRINGi9606.ENSP00000333157

Structurei

3D structure databases

ProteinModelPortaliP01242
SMRiP01242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000111012
HOGENOMiHOG000068443
HOVERGENiHBG011318
InParanoidiP01242
KOiK05438
OMAiTTMTHCS
OrthoDBiEOG091G0HM9
PhylomeDBiP01242
TreeFamiTF332592

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P01242-1) [UniParc]FASTAAdd to basket
Also known as: GH-V1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGSRTSLL LAFGLLCLSW LQEGSAFPTI PLSRLFDNAM LRARRLYQLA
60 70 80 90 100
YDTYQEFEEA YILKEQKYSF LQNPQTSLCF SESIPTPSNR VKTQQKSNLE
110 120 130 140 150
LLRISLLLIQ SWLEPVQLLR SVFANSLVYG ASDSNVYRHL KDLEEGIQTL
160 170 180 190 200
MWRLEDGSPR TGQIFNQSYS KFDTKSHNDD ALLKNYGLLY CFRKDMDKVE
210
TFLRIVQCRS VEGSCGF
Length:217
Mass (Da):25,000
Last modified:March 27, 2002 - v3
Checksum:i7B9324698E822F96
GO
Isoform 2 (identifier: P01242-2) [UniParc]FASTAAdd to basket
Also known as: GH-V2

The sequence of this isoform differs from the canonical sequence as follows:
     153-217: RLEDGSPRTG...CRSVEGSCGF → VRVAPGIPNP...ADLQSVLQQV

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,875
Checksum:i5D1C10B75BA49EC6
GO
Isoform 3 (identifier: P01242-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-72: Missing.

Show »
Length:202
Mass (Da):23,128
Checksum:i38B64D011A9197C6
GO
Isoform 4 (identifier: P01242-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-217: MWRLEDGSPR...CRSVEGSCGF → IGWKMAAPGL...VLLQCPPALS

Note: No experimental confirmation available.
Show »
Length:245
Mass (Da):27,101
Checksum:i14CC7F8CD75D91C8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXJ5A0A087WXJ5_HUMAN
Growth hormone variant
GH2
177Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44Missing AA sequence (PubMed:2196278).Curated1
Sequence conflicti109I → T in AAB59547 (PubMed:3379057).Curated1
Sequence conflicti109I → T in AAB59548 (PubMed:3379057).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01459190R → W. Corresponds to variant dbSNP:rs5389Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04320658 – 72Missing in isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_043480151 – 217MWRLE…GSCGF → IGWKMAAPGLGRSSISPTAS LTQNRTTMTHCSRTTGCSTA SGRTWTRSRHSCASCSAALW RAAVASSCPGGIPVTPPQCL SWSWKVLLQCPPALS in isoform 4. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_006203153 – 217RLEDG…GSCGF → VRVAPGIPNPGAPLASRDWG EKHCCPLFSSQALTQENSPY SSFPLVNPPGLSLQPGGEGG KWMNERGREQCPSAWPLLLF LHFAEAGRWQPPDWADLQSV LQQV in isoform 2. 2 PublicationsAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00470 Genomic DNA Translation: AAA98619.1
J03756 mRNA Translation: AAB59547.1
J03756 mRNA Translation: AAB59548.1
M38451 mRNA Translation: AAA35891.1
J03071 Genomic DNA Translation: AAA52552.1
AF006060 mRNA Translation: AAB71828.1
AF006061 mRNA Translation: AAB71829.1
EU421715 Genomic DNA Translation: ABZ88719.1
EU421715 Genomic DNA Translation: ABZ88720.1
EU421715 Genomic DNA Translation: ABZ88721.1
EU421715 Genomic DNA Translation: ABZ88722.1
AK312194 mRNA Translation: BAG35127.1
AB451332 mRNA Translation: BAG70146.1
AB451477 mRNA Translation: BAG70291.1
AC040958 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94238.1
CH471109 Genomic DNA Translation: EAW94248.1
CH471109 Genomic DNA Translation: EAW94252.1
CH471109 Genomic DNA Translation: EAW94258.1
BC020760 mRNA Translation: AAH20760.1
CCDSiCCDS11647.1 [P01242-1]
CCDS11648.1 [P01242-2]
CCDS45757.1 [P01242-4]
CCDS45758.1 [P01242-3]
PIRiA28072 STHUV2
D32435 STHUV
RefSeqiNP_002050.1, NM_002059.4 [P01242-1]
NP_072050.1, NM_022556.3 [P01242-3]
NP_072051.1, NM_022557.3 [P01242-2]
NP_072052.1, NM_022558.3 [P01242-4]
UniGeneiHs.406754
Hs.654390

Genome annotation databases

EnsembliENST00000332800; ENSP00000333157; ENSG00000136487 [P01242-2]
ENST00000423893; ENSP00000409294; ENSG00000136487 [P01242-1]
ENST00000449787; ENSP00000410618; ENSG00000136487 [P01242-3]
ENST00000456543; ENSP00000394122; ENSG00000136487 [P01242-4]
GeneIDi2689
KEGGihsa:2689
UCSCiuc002jcl.3 human [P01242-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00470 Genomic DNA Translation: AAA98619.1
J03756 mRNA Translation: AAB59547.1
J03756 mRNA Translation: AAB59548.1
M38451 mRNA Translation: AAA35891.1
J03071 Genomic DNA Translation: AAA52552.1
AF006060 mRNA Translation: AAB71828.1
AF006061 mRNA Translation: AAB71829.1
EU421715 Genomic DNA Translation: ABZ88719.1
EU421715 Genomic DNA Translation: ABZ88720.1
EU421715 Genomic DNA Translation: ABZ88721.1
EU421715 Genomic DNA Translation: ABZ88722.1
AK312194 mRNA Translation: BAG35127.1
AB451332 mRNA Translation: BAG70146.1
AB451477 mRNA Translation: BAG70291.1
AC040958 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94238.1
CH471109 Genomic DNA Translation: EAW94248.1
CH471109 Genomic DNA Translation: EAW94252.1
CH471109 Genomic DNA Translation: EAW94258.1
BC020760 mRNA Translation: AAH20760.1
CCDSiCCDS11647.1 [P01242-1]
CCDS11648.1 [P01242-2]
CCDS45757.1 [P01242-4]
CCDS45758.1 [P01242-3]
PIRiA28072 STHUV2
D32435 STHUV
RefSeqiNP_002050.1, NM_002059.4 [P01242-1]
NP_072050.1, NM_022556.3 [P01242-3]
NP_072051.1, NM_022557.3 [P01242-2]
NP_072052.1, NM_022558.3 [P01242-4]
UniGeneiHs.406754
Hs.654390

3D structure databases

ProteinModelPortaliP01242
SMRiP01242
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108956, 2 interactors
STRINGi9606.ENSP00000333157

PTM databases

iPTMnetiP01242
PhosphoSitePlusiP01242

Polymorphism and mutation databases

BioMutaiGH2

Proteomic databases

PaxDbiP01242
PeptideAtlasiP01242
PRIDEiP01242
ProteomicsDBi51357
51358 [P01242-2]
51359 [P01242-3]
51360 [P01242-4]

Protocols and materials databases

DNASUi2689
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332800; ENSP00000333157; ENSG00000136487 [P01242-2]
ENST00000423893; ENSP00000409294; ENSG00000136487 [P01242-1]
ENST00000449787; ENSP00000410618; ENSG00000136487 [P01242-3]
ENST00000456543; ENSP00000394122; ENSG00000136487 [P01242-4]
GeneIDi2689
KEGGihsa:2689
UCSCiuc002jcl.3 human [P01242-1]

Organism-specific databases

CTDi2689
DisGeNETi2689
EuPathDBiHostDB:ENSG00000136487.17
GeneCardsiGH2
HGNCiHGNC:4262 GH2
HPAiHPA043715
MIMi139240 gene
neXtProtiNX_P01242
OpenTargetsiENSG00000136487
PharmGKBiPA28672
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111012
HOGENOMiHOG000068443
HOVERGENiHBG011318
InParanoidiP01242
KOiK05438
OMAiTTMTHCS
OrthoDBiEOG091G0HM9
PhylomeDBiP01242
TreeFamiTF332592

Enzyme and pathway databases

ReactomeiR-HSA-1170546 Prolactin receptor signaling
R-HSA-982772 Growth hormone receptor signaling
SIGNORiP01242

Miscellaneous databases

ChiTaRSiGH2 human
GeneWikiiGrowth_hormone_2
GenomeRNAii2689
PROiPR:P01242
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136487 Expressed in 38 organ(s), highest expression level in chorionic villus
CleanExiHS_GH2
ExpressionAtlasiP01242 baseline and differential
GenevisibleiP01242 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOM2_HUMAN
AccessioniPrimary (citable) accession number: P01242
Secondary accession number(s): B1A4H5
, B1A4H7, O14643, O14644, P09587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 27, 2002
Last modified: November 7, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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