UniProtKB - P01241 (SOMA_HUMAN)
Somatotropin
GH1
Functioni
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 44 | ZincBy similarity | 1 | |
Metal bindingi | 200 | ZincBy similarity | 1 |
GO - Molecular functioni
- growth factor activity Source: BHF-UCL
- growth hormone receptor binding Source: MGI
- hormone activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- prolactin receptor binding Source: AgBase
GO - Biological processi
- animal organ development Source: GO_Central
- bone maturation Source: BHF-UCL
- growth hormone receptor signaling pathway Source: BHF-UCL
- positive regulation of activation of Janus kinase activity Source: BHF-UCL
- positive regulation of glucose transmembrane transport Source: MGI
- positive regulation of growth Source: GO_Central
- positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of MAP kinase activity Source: BHF-UCL
- positive regulation of multicellular organism growth Source: BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of receptor signaling pathway via JAK-STAT Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- receptor signaling pathway via JAK-STAT Source: BHF-UCL
- response to estradiol Source: BHF-UCL
- response to nutrient levels Source: GO_Central
Keywordsi
Molecular function | Hormone |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P01241 |
Reactomei | R-HSA-1170546, Prolactin receptor signaling R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin R-HSA-982772, Growth hormone receptor signaling |
SABIO-RKi | P01241 |
SignaLinki | P01241 |
SIGNORi | P01241 |
Names & Taxonomyi
Protein namesi | Recommended name: SomatotropinAlternative name(s): Growth hormone Short name: GH Short name: GH-N Growth hormone 1 Pituitary growth hormone |
Gene namesi | Name:GH1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4261, GH1 |
MIMi | 139250, gene |
neXtProti | NX_P01241 |
VEuPathDBi | HostDB:ENSG00000259384 |
Subcellular locationi
Extracellular region or secreted
Endosome
- endosome lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Other locations
- growth hormone receptor complex Source: CAFA
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Growth hormone deficiency, isolated, 1A (IGHD1A)1 Publication
Growth hormone deficiency, isolated, 1B (IGHD1B)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015801 | 16 | L → P in IGHD1B; suppresses secretion. 1 Publication | 1 | |
Natural variantiVAR_015802 | 37 | D → N in IGHD1B. 1 Publication | 1 | |
Natural variantiVAR_015803 | 42 | R → C in IGHD1B; reduced secretion. 1 PublicationCorresponds to variant dbSNP:rs71640273EnsemblClinVar. | 1 | |
Natural variantiVAR_015804 | 53 | T → I in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_015805 | 67 | K → R in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_015806 | 73 | N → D in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 PublicationCorresponds to variant dbSNP:rs71640276EnsemblClinVar. | 1 | |
Natural variantiVAR_015807 | 97 | S → F in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_015808 | 100 | E → K in IGHD1B. 1 Publication | 1 | |
Natural variantiVAR_015810 | 117 | Q → L in IGHD1B; reduced secretion. 1 Publication | 1 | |
Natural variantiVAR_015811 | 134 | S → C in IGHD1B. 1 Publication | 1 | |
Natural variantiVAR_015812 | 134 | S → R in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_015814 | 201 | T → A in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 |
Kowarski syndrome (KWKS)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015809 | 103 | R → C in KWKS; no effect on GHR signaling pathway; does not affect interaction with GHR; results in a stronger interaction with GHBP; does not affect subcellular location. 2 PublicationsCorresponds to variant dbSNP:rs137853220EnsemblClinVar. | 1 | |
Natural variantiVAR_015813 | 138 | D → G in KWKS; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853221EnsemblClinVar. | 1 |
Growth hormone deficiency, isolated, 2 (IGHD2)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015815 | 209 | R → H in IGHD2. 2 PublicationsCorresponds to variant dbSNP:rs137853223EnsemblClinVar. | 1 |
Pharmaceutical usei
Keywords - Diseasei
Disease variant, DwarfismOrganism-specific databases
DisGeNETi | 2688 |
MalaCardsi | GH1 |
MIMi | 173100, phenotype 262400, phenotype 262650, phenotype 612781, phenotype |
OpenTargetsi | ENSG00000259384 |
Orphaneti | 231662, Isolated growth hormone deficiency type IA 231671, Isolated growth hormone deficiency type IB 231679, Isolated growth hormone deficiency type II 629, Short stature due to growth hormone qualitative anomaly |
PharmGKBi | PA171 |
Miscellaneous databases
Pharosi | P01241, Tbio |
Genetic variation databases
BioMutai | GH1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 3 PublicationsAdd BLAST | 26 | |
ChainiPRO_0000032988 | 27 – 217 | SomatotropinAdd BLAST | 191 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 79 ↔ 191 | 1 Publication | ||
Modified residuei | 132 | Phosphoserine1 Publication | 1 | |
Modified residuei | 163 | Deamidated glutamine; by deterioration1 Publication | 1 | |
Modified residuei | 176 | Phosphoserine1 Publication | 1 | |
Modified residuei | 178 | Deamidated asparagine; by deterioration1 Publication | 1 | |
Disulfide bondi | 208 ↔ 215 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
MassIVEi | P01241 |
PaxDbi | P01241 |
PeptideAtlasi | P01241 |
PRIDEi | P01241 |
ProteomicsDBi | 51353 [P01241-1] 51354 [P01241-2] 51355 [P01241-3] 51356 [P01241-4] 982 |
PTM databases
iPTMneti | P01241 |
MetOSitei | P01241 |
PhosphoSitePlusi | P01241 |
Expressioni
Gene expression databases
Bgeei | ENSG00000259384, Expressed in adenohypophysis and 105 other tissues |
ExpressionAtlasi | P01241, baseline and differential |
Genevisiblei | P01241, HS |
Organism-specific databases
HPAi | ENSG00000259384, Tissue enriched (pituitary) |
Interactioni
Subunit structurei
Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homomeric and heteromeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.
Binary interactionsi
P01241
With | #Exp. | IntAct |
---|---|---|
GHR [P10912] | 4 | EBI-1026046,EBI-286316 |
GO - Molecular functioni
- growth factor activity Source: BHF-UCL
- growth hormone receptor binding Source: MGI
- hormone activity Source: GO_Central
- prolactin receptor binding Source: AgBase
Protein-protein interaction databases
BioGRIDi | 108955, 11 interactors |
DIPi | DIP-1022N |
IntActi | P01241, 5 interactors |
STRINGi | 9606.ENSP00000312673 |
Miscellaneous databases
RNActi | P01241, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P01241 |
SASBDBi | P01241 |
SMRi | P01241 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01241 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502R5GJ, Eukaryota |
GeneTreei | ENSGT00950000182818 |
HOGENOMi | CLU_088274_2_1_1 |
InParanoidi | P01241 |
OMAi | NSQVAFC |
PhylomeDBi | P01241 |
TreeFami | TF332592 |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR001400, Somatotropin/Prolactin IPR018116, Somatotropin_CS |
PANTHERi | PTHR11417, PTHR11417, 1 hit |
Pfami | View protein in Pfam PF00103, Hormone_1, 1 hit |
PRINTSi | PR00836, SOMATOTROPIN |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00266, SOMATOTROPIN_1, 1 hit PS00338, SOMATOTROPIN_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA
60 70 80 90 100
FDTYQEFEEA YIPKEQKYSF LQNPQTSLCF SESIPTPSNR EETQQKSNLE
110 120 130 140 150
LLRISLLLIQ SWLEPVQFLR SVFANSLVYG ASDSNVYDLL KDLEEGIQTL
160 170 180 190 200
MGRLEDGSPR TGQIFKQTYS KFDTNSHNDD ALLKNYGLLY CFRKDMDKVE
210
TFLRIVQCRS VEGSCGF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1A4G9 | B1A4G9_HUMAN | Growth hormone 1 isoform 4 | GH1 hCG_1749481 | 122 | Annotation score: | ||
A6NFB4 | A6NFB4_HUMAN | Chorionic somatomammotropin hormone... | CSH1 hCG_1749481 | 256 | Annotation score: | ||
H0YM39 | H0YM39_HUMAN | Chorionic somatomammotropin hormone... | CSH2 | 160 | Annotation score: | ||
B1A4H2 | B1A4H2_HUMAN | Chorionic somatomammotropin hormone... | CSH1 hCG_1749481 | 122 | Annotation score: | ||
A0A087WUG6 | A0A087WUG6_HUMAN | Chorionic somatomammotropin hormone... | CSH1 CSH2 | 128 | Annotation score: | ||
B1A4H0 | B1A4H0_HUMAN | Growth hormone 1 isoform 5 | GH1 | 30 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 35 | L → P in CAA23778 (PubMed:386281).Curated | 1 | |
Sequence conflicti | 40 | M → S in CAA23779 (PubMed:6269091).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011917 | 3 | T → A Found in patients with isolated growth hormone deficiency. 3 PublicationsCorresponds to variant dbSNP:rs2001345EnsemblClinVar. | 1 | |
Natural variantiVAR_015801 | 16 | L → P in IGHD1B; suppresses secretion. 1 Publication | 1 | |
Natural variantiVAR_015802 | 37 | D → N in IGHD1B. 1 Publication | 1 | |
Natural variantiVAR_015803 | 42 | R → C in IGHD1B; reduced secretion. 1 PublicationCorresponds to variant dbSNP:rs71640273EnsemblClinVar. | 1 | |
Natural variantiVAR_015804 | 53 | T → I in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_015805 | 67 | K → R in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_015806 | 73 | N → D in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 PublicationCorresponds to variant dbSNP:rs71640276EnsemblClinVar. | 1 | |
Natural variantiVAR_032702 | 79 | C → S in short stature; idiopathic autosomal; affects binding affinity of GH for GHR and the potency of GH to activate the JAK2/STAT5 signaling pathway. 1 PublicationCorresponds to variant dbSNP:rs137853222EnsemblClinVar. | 1 | |
Natural variantiVAR_015807 | 97 | S → F in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_015808 | 100 | E → K in IGHD1B. 1 Publication | 1 | |
Natural variantiVAR_015809 | 103 | R → C in KWKS; no effect on GHR signaling pathway; does not affect interaction with GHR; results in a stronger interaction with GHBP; does not affect subcellular location. 2 PublicationsCorresponds to variant dbSNP:rs137853220EnsemblClinVar. | 1 | |
Natural variantiVAR_011918 | 105 | S → C1 PublicationCorresponds to variant dbSNP:rs6174Ensembl. | 1 | |
Natural variantiVAR_015810 | 117 | Q → L in IGHD1B; reduced secretion. 1 Publication | 1 | |
Natural variantiVAR_015811 | 134 | S → C in IGHD1B. 1 Publication | 1 | |
Natural variantiVAR_015812 | 134 | S → R in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_011919 | 136 | V → I2 PublicationsCorresponds to variant dbSNP:rs5388EnsemblClinVar. | 1 | |
Natural variantiVAR_015813 | 138 | D → G in KWKS; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853221EnsemblClinVar. | 1 | |
Natural variantiVAR_015814 | 201 | T → A in IGHD1B; reduced ability to activate the JAK/STAT pathway. 1 Publication | 1 | |
Natural variantiVAR_032703 | 205 | I → M in short stature; idiopathic autosomal. 1 PublicationCorresponds to variant dbSNP:rs148474991EnsemblClinVar. | 1 | |
Natural variantiVAR_015815 | 209 | R → H in IGHD2. 2 PublicationsCorresponds to variant dbSNP:rs137853223EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045642 | 58 – 97 | Missing in isoform 5. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_006200 | 58 – 72 | Missing in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_006201 | 111 – 148 | Missing in isoform 3. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_006202 | 117 – 162 | Missing in isoform 4. 1 PublicationAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00519 mRNA Translation: CAA23778.1 V00520 Genomic DNA Translation: CAA23779.1 M13438 Genomic DNA Translation: AAA98618.1 J03071 Genomic DNA Translation: AAA52549.1 AF185611 mRNA Translation: AAG09699.1 AF110644 mRNA Translation: AAD48584.1 EU421712 Genomic DNA Translation: ABZ88713.1 AC127029 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94233.1 BC062475 mRNA Translation: AAH62475.1 BC075012 mRNA Translation: AAH75012.1 BC075013 mRNA Translation: AAH75013.1 BC090045 mRNA Translation: AAH90045.1 CD106566 mRNA No translation available. M14398 mRNA Translation: AAA52554.1 |
CCDSi | CCDS11653.1 [P01241-1] CCDS11654.1 [P01241-5] CCDS45760.1 [P01241-2] |
PIRi | A93731, STHU |
RefSeqi | NP_000506.2, NM_000515.4 [P01241-1] NP_072053.1, NM_022559.3 [P01241-2] NP_072054.1, NM_022560.3 [P01241-5] |
Genome annotation databases
Ensembli | ENST00000323322; ENSP00000312673; ENSG00000259384 ENST00000351388; ENSP00000343791; ENSG00000259384 [P01241-5] ENST00000458650; ENSP00000408486; ENSG00000259384 [P01241-2] |
GeneIDi | 2688 |
KEGGi | hsa:2688 |
MANE-Selecti | ENST00000323322.10; ENSP00000312673.5; NM_000515.5; NP_000506.2 |
UCSCi | uc002jdi.4, human [P01241-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Growth hormone entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00519 mRNA Translation: CAA23778.1 V00520 Genomic DNA Translation: CAA23779.1 M13438 Genomic DNA Translation: AAA98618.1 J03071 Genomic DNA Translation: AAA52549.1 AF185611 mRNA Translation: AAG09699.1 AF110644 mRNA Translation: AAD48584.1 EU421712 Genomic DNA Translation: ABZ88713.1 AC127029 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94233.1 BC062475 mRNA Translation: AAH62475.1 BC075012 mRNA Translation: AAH75012.1 BC075013 mRNA Translation: AAH75013.1 BC090045 mRNA Translation: AAH90045.1 CD106566 mRNA No translation available. M14398 mRNA Translation: AAA52554.1 |
CCDSi | CCDS11653.1 [P01241-1] CCDS11654.1 [P01241-5] CCDS45760.1 [P01241-2] |
PIRi | A93731, STHU |
RefSeqi | NP_000506.2, NM_000515.4 [P01241-1] NP_072053.1, NM_022559.3 [P01241-2] NP_072054.1, NM_022560.3 [P01241-5] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A22 | X-ray | 2.60 | A | 27-217 | [»] | |
1AXI | X-ray | 2.10 | A | 27-217 | [»] | |
1BP3 | X-ray | 2.90 | A | 27-217 | [»] | |
1HGU | X-ray | 2.50 | A | 27-217 | [»] | |
1HUW | X-ray | 2.00 | A | 27-217 | [»] | |
1HWG | X-ray | 2.50 | A | 27-217 | [»] | |
1HWH | X-ray | 2.90 | A | 27-217 | [»] | |
1KF9 | X-ray | 2.60 | A/D | 27-217 | [»] | |
3HHR | X-ray | 2.80 | A | 27-216 | [»] | |
6QIO | X-ray | 1.95 | D | 27-217 | [»] | |
BMRBi | P01241 | |||||
SASBDBi | P01241 | |||||
SMRi | P01241 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108955, 11 interactors |
DIPi | DIP-1022N |
IntActi | P01241, 5 interactors |
STRINGi | 9606.ENSP00000312673 |
PTM databases
iPTMneti | P01241 |
MetOSitei | P01241 |
PhosphoSitePlusi | P01241 |
Genetic variation databases
BioMutai | GH1 |
Proteomic databases
MassIVEi | P01241 |
PaxDbi | P01241 |
PeptideAtlasi | P01241 |
PRIDEi | P01241 |
ProteomicsDBi | 51353 [P01241-1] 51354 [P01241-2] 51355 [P01241-3] 51356 [P01241-4] 982 |
Protocols and materials databases
Antibodypediai | 52672, 1349 antibodies from 37 providers |
DNASUi | 2688 |
Genome annotation databases
Ensembli | ENST00000323322; ENSP00000312673; ENSG00000259384 ENST00000351388; ENSP00000343791; ENSG00000259384 [P01241-5] ENST00000458650; ENSP00000408486; ENSG00000259384 [P01241-2] |
GeneIDi | 2688 |
KEGGi | hsa:2688 |
MANE-Selecti | ENST00000323322.10; ENSP00000312673.5; NM_000515.5; NP_000506.2 |
UCSCi | uc002jdi.4, human [P01241-1] |
Organism-specific databases
CTDi | 2688 |
DisGeNETi | 2688 |
GeneCardsi | GH1 |
HGNCi | HGNC:4261, GH1 |
HPAi | ENSG00000259384, Tissue enriched (pituitary) |
MalaCardsi | GH1 |
MIMi | 139250, gene 173100, phenotype 262400, phenotype 262650, phenotype 612781, phenotype |
neXtProti | NX_P01241 |
OpenTargetsi | ENSG00000259384 |
Orphaneti | 231662, Isolated growth hormone deficiency type IA 231671, Isolated growth hormone deficiency type IB 231679, Isolated growth hormone deficiency type II 629, Short stature due to growth hormone qualitative anomaly |
PharmGKBi | PA171 |
VEuPathDBi | HostDB:ENSG00000259384 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R5GJ, Eukaryota |
GeneTreei | ENSGT00950000182818 |
HOGENOMi | CLU_088274_2_1_1 |
InParanoidi | P01241 |
OMAi | NSQVAFC |
PhylomeDBi | P01241 |
TreeFami | TF332592 |
Enzyme and pathway databases
PathwayCommonsi | P01241 |
Reactomei | R-HSA-1170546, Prolactin receptor signaling R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin R-HSA-982772, Growth hormone receptor signaling |
SABIO-RKi | P01241 |
SignaLinki | P01241 |
SIGNORi | P01241 |
Miscellaneous databases
BioGRID-ORCSi | 2688, 4 hits in 1004 CRISPR screens |
ChiTaRSi | GH1, human |
EvolutionaryTracei | P01241 |
GenomeRNAii | 2688 |
Pharosi | P01241, Tbio |
PROi | PR:P01241 |
RNActi | P01241, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000259384, Expressed in adenohypophysis and 105 other tissues |
ExpressionAtlasi | P01241, baseline and differential |
Genevisiblei | P01241, HS |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR001400, Somatotropin/Prolactin IPR018116, Somatotropin_CS |
PANTHERi | PTHR11417, PTHR11417, 1 hit |
Pfami | View protein in Pfam PF00103, Hormone_1, 1 hit |
PRINTSi | PR00836, SOMATOTROPIN |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00266, SOMATOTROPIN_1, 1 hit PS00338, SOMATOTROPIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SOMA_HUMAN | |
Accessioni | P01241Primary (citable) accession number: P01241 Secondary accession number(s): A6NEF6 Q9UNL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 235 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Pharmaceutical, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families