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Protein

Lutropin subunit beta

Gene

Lhb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-193048 Androgen biosynthesis
R-RNO-193993 Mineralocorticoid biosynthesis
R-RNO-209822 Glycoprotein hormones
R-RNO-375281 Hormone ligand-binding receptors
R-RNO-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-RNO-975578 Reactions specific to the complex N-glycan synthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Short name:
Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Gene namesi
Name:Lhb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3006 Lhb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001173321 – 141Lutropin subunit betaAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 77By similarity
Glycosylationi33N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01230

Expressioni

Gene expression databases

BgeeiENSRNOG00000047040 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiP01230 baseline and differential
GenevisibleiP01230 RN

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060360

Structurei

3D structure databases

ProteinModelPortaliP01230
SMRiP01230
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP01230
KOiK08521
OMAiTTTICAG
OrthoDBiEOG091G0XFH
PhylomeDBiP01230
TreeFamiTF332940

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01230-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERLQGLLLW LLLSPSVVWA SRGPLRPLCR PVNATLAAEN EFCPVCITFT
60 70 80 90 100
TSICAGYCPS MVRVLPAALP PVPQPVCTYR ELRFASVRLP GCPPGVDPIV
110 120 130 140
SFPVALSCRC GPCRLSSSDC GGPRTQPMTC DLPHLPGLLL F
Length:141
Mass (Da):15,177
Last modified:July 21, 1986 - v1
Checksum:i50796FB8E32F83BF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LQA4F1LQA4_RAT
Lutropin subunit beta
Lhb LOC100359572
139Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01542 mRNA Translation: CAA24783.1
J00749 Genomic DNA Translation: AAA96703.1
D00576 mRNA Translation: BAA00454.1
PIRiA01498 UTRTB
RefSeqiNP_001029147.1, NM_001033975.1
NP_036990.1, NM_012858.2
UniGeneiRn.10108
Rn.224467

Genome annotation databases

EnsembliENSRNOT00000067468; ENSRNOP00000060360; ENSRNOG00000047040
GeneIDi25329
KEGGirno:25329
UCSCiRGD:3006 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01542 mRNA Translation: CAA24783.1
J00749 Genomic DNA Translation: AAA96703.1
D00576 mRNA Translation: BAA00454.1
PIRiA01498 UTRTB
RefSeqiNP_001029147.1, NM_001033975.1
NP_036990.1, NM_012858.2
UniGeneiRn.10108
Rn.224467

3D structure databases

ProteinModelPortaliP01230
SMRiP01230
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060360

Proteomic databases

PaxDbiP01230

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067468; ENSRNOP00000060360; ENSRNOG00000047040
GeneIDi25329
KEGGirno:25329
UCSCiRGD:3006 rat

Organism-specific databases

CTDi3972
RGDi3006 Lhb

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP01230
KOiK08521
OMAiTTTICAG
OrthoDBiEOG091G0XFH
PhylomeDBiP01230
TreeFamiTF332940

Enzyme and pathway databases

ReactomeiR-RNO-193048 Androgen biosynthesis
R-RNO-193993 Mineralocorticoid biosynthesis
R-RNO-209822 Glycoprotein hormones
R-RNO-375281 Hormone ligand-binding receptors
R-RNO-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-RNO-975578 Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

PROiPR:P01230

Gene expression databases

BgeeiENSRNOG00000047040 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiP01230 baseline and differential
GenevisibleiP01230 RN

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSHB_RAT
AccessioniPrimary (citable) accession number: P01230
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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