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Protein

Lutropin subunit beta

Gene

LHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-193048 Androgen biosynthesis
R-HSA-193993 Mineralocorticoid biosynthesis
R-HSA-209822 Glycoprotein hormones
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
SIGNORiP01229

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Short name:
Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Gene namesi
Name:LHB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104826.11
HGNCiHGNC:6584 LHB
MIMi152780 gene
neXtProtiNX_P01229

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 23 without anosmia (HH23)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.
See also OMIM:228300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00318974Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant dbSNP:rs5030773EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism

Organism-specific databases

DisGeNETi3972
MalaCardsiLHB
MIMi228300 phenotype
OpenTargetsiENSG00000104826
Orphaneti325448 Leydig cell hypoplasia due to LHB deficiency
PharmGKBiPA30356

Polymorphism and mutation databases

BioMutaiLHB
DMDMi1170834

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001172621 – 141Lutropin subunit betaAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 77By similarity
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
GlycosylationiCAR_00004550N-linked (GlcNAc...) asparagine1
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01229
PeptideAtlasiP01229
PRIDEiP01229
ProteomicsDBi51349

PTM databases

GlyConnecti350
UniCarbKBiP01229

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

BgeeiENSG00000104826 Expressed in 107 organ(s), highest expression level in adenohypophysis
CleanExiHS_LHB
ExpressionAtlasiP01229 baseline and differential
GenevisibleiP01229 HS

Organism-specific databases

HPAiCAB022241
CAB022707
HPA038925

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01229, 4 interactors
STRINGi9606.ENSP00000221421

Structurei

3D structure databases

ProteinModelPortaliP01229
SMRiP01229
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP01229
KOiK08521
OMAiTICSGHC
PhylomeDBiP01229
TreeFamiTF332940

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01229-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN
60 70 80 90 100
TTICAGYCPT MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV
110 120 130 140
SFPVALSCRC GPCRRSTSDC GGPKDHPLTC DHPQLSGLLF L
Length:141
Mass (Da):15,345
Last modified:November 1, 1995 - v3
Checksum:iE411766253113F7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39E → Q AA sequence (PubMed:1191677).Curated1
Sequence conflicti76Missing AA sequence (PubMed:1191677).Curated1
Sequence conflicti132 – 135HPQL → PQH AA sequence (PubMed:1191677).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03409815M → I. Corresponds to variant dbSNP:rs34247911Ensembl.1
Natural variantiVAR_01567218A → T More effective in stimulating IP3 but not cAMP production. 1 PublicationCorresponds to variant dbSNP:rs5030775Ensembl.1
Natural variantiVAR_01458928W → R1 PublicationCorresponds to variant dbSNP:rs1800447EnsemblClinVar.1
Natural variantiVAR_01459035I → T1 PublicationCorresponds to variant dbSNP:rs34349826EnsemblClinVar.1
Natural variantiVAR_00318974Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant dbSNP:rs5030773EnsemblClinVar.1
Natural variantiVAR_015673122G → S May be implicated in female infertility. 1 PublicationCorresponds to variant dbSNP:rs5030774EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00264 Genomic DNA Translation: CAA25067.1
S71273 Genomic DNA Translation: AAD14960.1 Sequence problems.
CCDSiCCDS12748.1
PIRiI37994 UTHUB
RefSeqiNP_000885.1, NM_000894.2
UniGeneiHs.154704

Genome annotation databases

EnsembliENST00000221421; ENSP00000221421; ENSG00000104826
GeneIDi3972
KEGGihsa:3972
UCSCiuc002plt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Luteinizing hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00264 Genomic DNA Translation: CAA25067.1
S71273 Genomic DNA Translation: AAD14960.1 Sequence problems.
CCDSiCCDS12748.1
PIRiI37994 UTHUB
RefSeqiNP_000885.1, NM_000894.2
UniGeneiHs.154704

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M92model-A1-141[»]
ProteinModelPortaliP01229
SMRiP01229
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01229, 4 interactors
STRINGi9606.ENSP00000221421

PTM databases

GlyConnecti350
UniCarbKBiP01229

Polymorphism and mutation databases

BioMutaiLHB
DMDMi1170834

Proteomic databases

PaxDbiP01229
PeptideAtlasiP01229
PRIDEiP01229
ProteomicsDBi51349

Protocols and materials databases

DNASUi3972
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221421; ENSP00000221421; ENSG00000104826
GeneIDi3972
KEGGihsa:3972
UCSCiuc002plt.4 human

Organism-specific databases

CTDi3972
DisGeNETi3972
EuPathDBiHostDB:ENSG00000104826.11
GeneCardsiLHB
HGNCiHGNC:6584 LHB
HPAiCAB022241
CAB022707
HPA038925
MalaCardsiLHB
MIMi152780 gene
228300 phenotype
neXtProtiNX_P01229
OpenTargetsiENSG00000104826
Orphaneti325448 Leydig cell hypoplasia due to LHB deficiency
PharmGKBiPA30356
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0DB Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP01229
KOiK08521
OMAiTICSGHC
PhylomeDBiP01229
TreeFamiTF332940

Enzyme and pathway databases

ReactomeiR-HSA-193048 Androgen biosynthesis
R-HSA-193993 Mineralocorticoid biosynthesis
R-HSA-209822 Glycoprotein hormones
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
SIGNORiP01229

Miscellaneous databases

GeneWikiiLuteinizing_hormone_beta_polypeptide
GenomeRNAii3972
PROiPR:P01229
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104826 Expressed in 107 organ(s), highest expression level in adenohypophysis
CleanExiHS_LHB
ExpressionAtlasiP01229 baseline and differential
GenevisibleiP01229 HS

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSHB_HUMAN
AccessioniPrimary (citable) accession number: P01229
Secondary accession number(s): Q9UDI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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