UniProtKB - P01229 (LSHB_HUMAN)
Protein
Lutropin subunit beta
Gene
LHB
Organism
Homo sapiens (Human)
Status
Functioni
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- signaling receptor binding Source: ProtInc
GO - Biological processi
- cell-cell signaling Source: ProtInc
- G protein-coupled receptor signaling pathway Source: GO_Central
- hormone-mediated signaling pathway Source: GO_Central
- male gonad development Source: ProtInc
- peptide hormone processing Source: Reactome
- progesterone biosynthetic process Source: BHF-UCL
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | P01229 |
Reactomei | R-HSA-193048, Androgen biosynthesis R-HSA-193993, Mineralocorticoid biosynthesis R-HSA-209822, Glycoprotein hormones R-HSA-375281, Hormone ligand-binding receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-975578, Reactions specific to the complex N-glycan synthesis pathway |
SIGNORi | P01229 |
Names & Taxonomyi
Protein namesi | Recommended name: Lutropin subunit betaShort name: Lutropin beta chain Alternative name(s): Luteinizing hormone subunit beta Short name: LH-B Short name: LSH-B Short name: LSH-beta |
Gene namesi | Name:LHB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6584, LHB |
MIMi | 152780, gene |
neXtProti | NX_P01229 |
VEuPathDBi | HostDB:ENSG00000104826.11 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi lumen Source: Reactome
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Hypogonadotropic hypogonadism 23 without anosmia (HH23)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003189 | 74 | Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant dbSNP:rs5030773Ensembl. | 1 |
Keywords - Diseasei
Disease variant, Hypogonadotropic hypogonadismOrganism-specific databases
DisGeNETi | 3972 |
MalaCardsi | LHB |
MIMi | 228300, phenotype |
OpenTargetsi | ENSG00000104826 |
Orphaneti | 325448, Leydig cell hypoplasia due to LHB deficiency |
PharmGKBi | PA30356 |
Miscellaneous databases
Pharosi | P01229, Tbio |
Genetic variation databases
BioMutai | LHB |
DMDMi | 1170834 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000011726 | 21 – 141 | Lutropin subunit betaAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 77 | By similarity | ||
Disulfide bondi | 43 ↔ 92 | By similarity | ||
Disulfide bondi | 46 ↔ 130 | By similarity | ||
GlycosylationiCAR_000045 | 50 | N-linked (GlcNAc...) asparagine | 1 | |
Disulfide bondi | 54 ↔ 108 | By similarity | ||
Disulfide bondi | 58 ↔ 110 | By similarity | ||
Disulfide bondi | 113 ↔ 120 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P01229 |
PaxDbi | P01229 |
PeptideAtlasi | P01229 |
PRIDEi | P01229 |
ProteomicsDBi | 51349 |
PTM databases
GlyConnecti | 350, 18 N-Linked glycans (1 site) |
GlyGeni | P01229, 1 site, 18 N-linked glycans (1 site) |
Expressioni
Tissue specificityi
Pituitary gland.
Gene expression databases
Bgeei | ENSG00000104826, Expressed in adenohypophysis and 143 other tissues |
ExpressionAtlasi | P01229, baseline and differential |
Genevisiblei | P01229, HS |
Organism-specific databases
HPAi | ENSG00000104826, Tissue enriched (pituitary) |
Interactioni
Subunit structurei
Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
Binary interactionsi
Hide detailsP01229
With | #Exp. | IntAct |
---|---|---|
FHL3 [Q13643] | 3 | EBI-11659791,EBI-741101 |
NTM - isoform 3 [Q9P121-3] | 3 | EBI-11659791,EBI-12027160 |
SGTB [Q96EQ0] | 3 | EBI-11659791,EBI-744081 |
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- signaling receptor binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 110160, 3 interactors |
ComplexPortali | CPX-6097, Luteinizing hormone complex |
IntActi | P01229, 4 interactors |
STRINGi | 9606.ENSP00000221421 |
Miscellaneous databases
RNActi | P01229, protein |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S49V, Eukaryota |
GeneTreei | ENSGT00940000163162 |
HOGENOMi | CLU_126319_0_0_1 |
InParanoidi | P01229 |
OMAi | NSICAGY |
OrthoDBi | 1362225at2759 |
PhylomeDBi | P01229 |
TreeFami | TF332940 |
Family and domain databases
CDDi | cd00069, GHB_like, 1 hit |
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR006208, Glyco_hormone_CN IPR001545, Gonadotropin_bsu IPR018245, Gonadotropin_bsu_CS |
PANTHERi | PTHR11515, PTHR11515, 1 hit |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit |
SMARTi | View protein in SMART SM00068, GHB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00261, GLYCO_HORMONE_BETA_1, 1 hit PS00689, GLYCO_HORMONE_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01229-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN
60 70 80 90 100
TTICAGYCPT MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV
110 120 130 140
SFPVALSCRC GPCRRSTSDC GGPKDHPLTC DHPQLSGLLF L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | E → Q AA sequence (PubMed:1191677).Curated | 1 | |
Sequence conflicti | 76 | Missing AA sequence (PubMed:1191677).Curated | 1 | |
Sequence conflicti | 132 – 135 | HPQL → PQH AA sequence (PubMed:1191677).Curated | 4 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034098 | 15 | M → I. Corresponds to variant dbSNP:rs34247911Ensembl. | 1 | |
Natural variantiVAR_015672 | 18 | A → T More effective in stimulating IP3 but not cAMP production. 1 PublicationCorresponds to variant dbSNP:rs5030775Ensembl. | 1 | |
Natural variantiVAR_014589 | 28 | W → R1 PublicationCorresponds to variant dbSNP:rs1800447EnsemblClinVar. | 1 | |
Natural variantiVAR_014590 | 35 | I → T1 PublicationCorresponds to variant dbSNP:rs34349826EnsemblClinVar. | 1 | |
Natural variantiVAR_003189 | 74 | Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant dbSNP:rs5030773Ensembl. | 1 | |
Natural variantiVAR_015673 | 122 | G → S May be implicated in female infertility. 1 PublicationCorresponds to variant dbSNP:rs5030774EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00264 Genomic DNA Translation: CAA25067.1 S71273 Genomic DNA Translation: AAD14960.1 Sequence problems. |
CCDSi | CCDS12748.1 |
PIRi | I37994, UTHUB |
RefSeqi | NP_000885.1, NM_000894.2 |
Genome annotation databases
Ensembli | ENST00000649238; ENSP00000497294; ENSG00000104826 |
GeneIDi | 3972 |
KEGGi | hsa:3972 |
UCSCi | uc002plt.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Luteinizing hormone entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00264 Genomic DNA Translation: CAA25067.1 S71273 Genomic DNA Translation: AAD14960.1 Sequence problems. |
CCDSi | CCDS12748.1 |
PIRi | I37994, UTHUB |
RefSeqi | NP_000885.1, NM_000894.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1M92 | model | - | A | 1-141 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110160, 3 interactors |
ComplexPortali | CPX-6097, Luteinizing hormone complex |
IntActi | P01229, 4 interactors |
STRINGi | 9606.ENSP00000221421 |
PTM databases
GlyConnecti | 350, 18 N-Linked glycans (1 site) |
GlyGeni | P01229, 1 site, 18 N-linked glycans (1 site) |
Genetic variation databases
BioMutai | LHB |
DMDMi | 1170834 |
Proteomic databases
MassIVEi | P01229 |
PaxDbi | P01229 |
PeptideAtlasi | P01229 |
PRIDEi | P01229 |
ProteomicsDBi | 51349 |
Protocols and materials databases
Antibodypediai | 18479, 777 antibodies |
DNASUi | 3972 |
Genome annotation databases
Ensembli | ENST00000649238; ENSP00000497294; ENSG00000104826 |
GeneIDi | 3972 |
KEGGi | hsa:3972 |
UCSCi | uc002plt.4, human |
Organism-specific databases
CTDi | 3972 |
DisGeNETi | 3972 |
GeneCardsi | LHB |
HGNCi | HGNC:6584, LHB |
HPAi | ENSG00000104826, Tissue enriched (pituitary) |
MalaCardsi | LHB |
MIMi | 152780, gene 228300, phenotype |
neXtProti | NX_P01229 |
OpenTargetsi | ENSG00000104826 |
Orphaneti | 325448, Leydig cell hypoplasia due to LHB deficiency |
PharmGKBi | PA30356 |
VEuPathDBi | HostDB:ENSG00000104826.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S49V, Eukaryota |
GeneTreei | ENSGT00940000163162 |
HOGENOMi | CLU_126319_0_0_1 |
InParanoidi | P01229 |
OMAi | NSICAGY |
OrthoDBi | 1362225at2759 |
PhylomeDBi | P01229 |
TreeFami | TF332940 |
Enzyme and pathway databases
PathwayCommonsi | P01229 |
Reactomei | R-HSA-193048, Androgen biosynthesis R-HSA-193993, Mineralocorticoid biosynthesis R-HSA-209822, Glycoprotein hormones R-HSA-375281, Hormone ligand-binding receptors R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-975578, Reactions specific to the complex N-glycan synthesis pathway |
SIGNORi | P01229 |
Miscellaneous databases
BioGRID-ORCSi | 3972, 5 hits in 871 CRISPR screens |
GeneWikii | Luteinizing_hormone_beta_polypeptide |
GenomeRNAii | 3972 |
Pharosi | P01229, Tbio |
PROi | PR:P01229 |
RNActi | P01229, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104826, Expressed in adenohypophysis and 143 other tissues |
ExpressionAtlasi | P01229, baseline and differential |
Genevisiblei | P01229, HS |
Family and domain databases
CDDi | cd00069, GHB_like, 1 hit |
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR006208, Glyco_hormone_CN IPR001545, Gonadotropin_bsu IPR018245, Gonadotropin_bsu_CS |
PANTHERi | PTHR11515, PTHR11515, 1 hit |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit |
SMARTi | View protein in SMART SM00068, GHB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00261, GLYCO_HORMONE_BETA_1, 1 hit PS00689, GLYCO_HORMONE_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LSHB_HUMAN | |
Accessioni | P01229Primary (citable) accession number: P01229 Secondary accession number(s): Q9UDI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families