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UniProtKB - P01229 (LSHB_HUMAN)

Entry version 202 (25 May 2022)
Sequence version 3 (01 Nov 1995)
Previous versions | rss
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Protein

Lutropin subunit beta

Gene

LHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01229

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193048, Androgen biosynthesis
R-HSA-193993, Mineralocorticoid biosynthesis
R-HSA-209822, Glycoprotein hormones
R-HSA-375281, Hormone ligand-binding receptors
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-975578, Reactions specific to the complex N-glycan synthesis pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P01229

SIGNOR Signaling Network Open Resource

More...SIGNORi		P01229

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lutropin subunit beta
Short name:
Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LHB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6584, LHB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		152780, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01229

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000104826

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypogonadotropic hypogonadism 23 with or without anosmia (HH23)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00318974Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant dbSNP:rs5030773EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Hypogonadotropic hypogonadism

Organism-specific databases

DisGeNET

More...DisGeNETi		3972

MalaCards human disease database

More...MalaCardsi		LHB
MIMi228300, phenotype

Open Targets

More...OpenTargetsi		ENSG00000104826

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		325448, Leydig cell hypoplasia due to LHB deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30356

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01229, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LHB

Domain mapping of disease mutations (DMDM)

More...DMDMi		1170834

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001172621 – 141Lutropin subunit betaAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 77By similarity
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00004550N-linked (GlcNAc...) asparagine1
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01229

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01229

PeptideAtlas

More...PeptideAtlasi		P01229

PRoteomics IDEntifications database

More...PRIDEi		P01229

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51349

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		350, 18 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P01229, 1 site, 32 N-linked glycans (1 site)

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Pituitary gland.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104826, Expressed in adenohypophysis and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P01229, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01229, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104826, Tissue enriched (pituitary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110160, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6097, Luteinizing hormone complex

Protein interaction database and analysis system

More...IntActi		P01229, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000221421

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01229, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P01229

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01229

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycoprotein hormones subunit beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S49V, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163162

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_126319_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01229

Identification of Orthologs from Complete Genome Data

More...OMAi		NSICAGY

Database of Orthologous Groups

More...OrthoDBi		1362225at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01229

TreeFam database of animal gene trees

More...TreeFami		TF332940

Family and domain databases

Conserved Domains Database

More...CDDi		cd00069, GHB_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR006208, Glyco_hormone_CN
IPR001545, Gonadotropin_bsu
IPR018245, Gonadotropin_bsu_CS

The PANTHER Classification System

More...PANTHERi		PTHR11515, PTHR11515, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00007, Cys_knot, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00068, GHB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57501, SSF57501, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00261, GLYCO_HORMONE_BETA_1, 1 hit
PS00689, GLYCO_HORMONE_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01229-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN 
        60         70         80         90        100
TTICAGYCPT MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV 
       110        120        130        140 
SFPVALSCRC GPCRRSTSDC GGPKDHPLTC DHPQLSGLLF L
Length:141
Mass (Da):15,345
Last modified:November 1, 1995 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE411766253113F7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39E → Q AA sequence (PubMed:1191677).Curated1
Sequence conflicti76Missing AA sequence (PubMed:1191677).Curated1
Sequence conflicti132 – 135HPQL → PQH AA sequence (PubMed:1191677).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03409815M → I. Corresponds to variant dbSNP:rs34247911Ensembl.1
Natural variantiVAR_01567218A → T More effective in stimulating IP3 but not cAMP production. 1 PublicationCorresponds to variant dbSNP:rs5030775Ensembl.1
Natural variantiVAR_01458928W → R1 PublicationCorresponds to variant dbSNP:rs1800447EnsemblClinVar.1
Natural variantiVAR_01459035I → T1 PublicationCorresponds to variant dbSNP:rs34349826EnsemblClinVar.1
Natural variantiVAR_00318974Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant dbSNP:rs5030773EnsemblClinVar.1
Natural variantiVAR_015673122G → S May be implicated in female infertility. 1 PublicationCorresponds to variant dbSNP:rs5030774EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X00264 Genomic DNA Translation: CAA25067.1
S71273 Genomic DNA Translation: AAD14960.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12748.1

Protein sequence database of the Protein Information Resource

More...PIRi		I37994, UTHUB

NCBI Reference Sequences

More...RefSeqi		NP_000885.1, NM_000894.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000649238.3; ENSP00000497294.2; ENSG00000104826.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3972

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3972

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000649238.3; ENSP00000497294.2; NM_000894.3; NP_000885.1

UCSC genome browser

More...UCSCi		uc002plt.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Luteinizing hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00264 Genomic DNA Translation: CAA25067.1
S71273 Genomic DNA Translation: AAD14960.1 Sequence problems.
CCDSiCCDS12748.1
PIRiI37994, UTHUB
RefSeqiNP_000885.1, NM_000894.2

3D structure databases

AlphaFoldDBiP01229
SMRiP01229
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110160, 4 interactors
ComplexPortaliCPX-6097, Luteinizing hormone complex
IntActiP01229, 4 interactors
STRINGi9606.ENSP00000221421

PTM databases

GlyConnecti350, 18 N-Linked glycans (1 site)
GlyGeniP01229, 1 site, 32 N-linked glycans (1 site)

Genetic variation databases

BioMutaiLHB
DMDMi1170834

Proteomic databases

MassIVEiP01229
PaxDbiP01229
PeptideAtlasiP01229
PRIDEiP01229
ProteomicsDBi51349

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18479, 801 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		3972

Genome annotation databases

EnsembliENST00000649238.3; ENSP00000497294.2; ENSG00000104826.15
GeneIDi3972
KEGGihsa:3972
MANE-SelectiENST00000649238.3; ENSP00000497294.2; NM_000894.3; NP_000885.1
UCSCiuc002plt.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3972
DisGeNETi3972

GeneCards: human genes, protein and diseases

More...GeneCardsi		LHB
HGNCiHGNC:6584, LHB
HPAiENSG00000104826, Tissue enriched (pituitary)
MalaCardsiLHB
MIMi152780, gene
228300, phenotype
neXtProtiNX_P01229
OpenTargetsiENSG00000104826
Orphaneti325448, Leydig cell hypoplasia due to LHB deficiency
PharmGKBiPA30356
VEuPathDBiHostDB:ENSG00000104826

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S49V, Eukaryota
GeneTreeiENSGT00940000163162
HOGENOMiCLU_126319_0_0_1
InParanoidiP01229
OMAiNSICAGY
OrthoDBi1362225at2759
PhylomeDBiP01229
TreeFamiTF332940

Enzyme and pathway databases

PathwayCommonsiP01229
ReactomeiR-HSA-193048, Androgen biosynthesis
R-HSA-193993, Mineralocorticoid biosynthesis
R-HSA-209822, Glycoprotein hormones
R-HSA-375281, Hormone ligand-binding receptors
R-HSA-418555, G alpha (s) signalling events
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-975578, Reactions specific to the complex N-glycan synthesis pathway
SignaLinkiP01229
SIGNORiP01229

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3972, 7 hits in 1061 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Luteinizing_hormone_beta_polypeptide

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3972
PharosiP01229, Tbio

Protein Ontology

More...PROi		PR:P01229
RNActiP01229, protein

The Stanford Online Universal Resource for Clones and ESTs

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Gene expression databases

BgeeiENSG00000104826, Expressed in adenohypophysis and 144 other tissues
ExpressionAtlasiP01229, baseline and differential
GenevisibleiP01229, HS

Family and domain databases

CDDicd00069, GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR006208, Glyco_hormone_CN
IPR001545, Gonadotropin_bsu
IPR018245, Gonadotropin_bsu_CS
PANTHERiPTHR11515, PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007, Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068, GHB, 1 hit
SUPFAMiSSF57501, SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261, GLYCO_HORMONE_BETA_1, 1 hit
PS00689, GLYCO_HORMONE_BETA_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLSHB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01229
Secondary accession number(s): Q9UDI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: May 25, 2022
This is version 202 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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