LHB

Functionⁱ

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 10484773

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 10484773
G-protein coupled receptor signaling pathway Source: GO_Central
hormone-mediated signaling pathway Source: GO_Central
male gonad development
Source: ProtInc
Traceable author statementⁱ
- 6785294
ovulation Source: GO_Central
peptide hormone processing Source: Reactome
progesterone biosynthetic process
Source: BHF-UCL
Traceable author statementⁱ
- 14557487
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10484773

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-193048 Androgen biosynthesis R-HSA-193993 Mineralocorticoid biosynthesis R-HSA-209822 Glycoprotein hormones R-HSA-375281 Hormone ligand-binding receptors R-HSA-418555 G alpha (s) signalling events R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
SIGNORⁱ	P01229

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lutropin subunit beta Short name: Lutropin beta chain Alternative name(s): Luteinizing hormone subunit beta Short name: LH-B Short name: LSH-B Short name: LSH-beta
Gene namesⁱ	Name:LHB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104826.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6584 LHB
MIMⁱ	152780 gene
neXtProtⁱ	NX_P01229

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hypogonadotropic hypogonadism 23 without anosmia (HH23)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_003189	74	Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant dbSNP:rs5030773EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Hypogonadotropic hypogonadism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3972
MalaCards human disease database More...MalaCardsⁱ	LHB
MIMⁱ	228300 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000104826
Orphanetⁱ	325448 Leydig cell hypoplasia due to LHB deficiency
PharmGKBⁱ	PA30356

Polymorphism and mutation databases

BioMutaⁱ	LHB
DMDMⁱ	1170834

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	1 PublicationAdd BLAST		20
ChainⁱPRO_0000011726	21 – 141	Lutropin subunit betaAdd BLAST		121

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	29 ↔ 77	By similarity
Disulfide bondⁱ	43 ↔ 92	By similarity
Disulfide bondⁱ	46 ↔ 130	By similarity
GlycosylationⁱCAR_000045	50	N-linked (GlcNAc...) asparagine	1
Disulfide bondⁱ	54 ↔ 108	By similarity
Disulfide bondⁱ	58 ↔ 110	By similarity
Disulfide bondⁱ	113 ↔ 120	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P01229
PeptideAtlas More...PeptideAtlasⁱ	P01229
PRIDEⁱ	P01229
ProteomicsDBⁱ	51349

PTM databases

GlyConnectⁱ	350
UniCarbKBⁱ	P01229

Expressionⁱ

Tissue specificityⁱ

Pituitary gland.

Gene expression databases

Bgeeⁱ	ENSG00000104826 Expressed in 107 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_LHB
ExpressionAtlasⁱ	P01229 baseline and differential
Genevisibleⁱ	P01229 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022241 CAB022707 HPA038925

HPAⁱ

CAB022241
CAB022707
HPA038925

Interactionⁱ

Subunit structureⁱ

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 10484773

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P01229, 4 interactors
STRINGⁱ	9606.ENSP00000221421

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01229
SMRⁱ	P01229
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycoprotein hormones subunit beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J0DB Eukaryota ENOG4111ZSU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010115
HOGENOMⁱ	HOG000116098
HOVERGENⁱ	HBG006698
InParanoidⁱ	P01229
KEGG Orthology (KO) More...KOⁱ	K08521
OMAⁱ	TICSGHC
PhylomeDBⁱ	P01229
TreeFamⁱ	TF332940

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00069 GHB_like, 1 hit
Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR006208 Glyco_hormone_CN IPR001545 Gonadotropin_bsu IPR018245 Gonadotropin_bsu_CS
PANTHERⁱ	PTHR11515 PTHR11515, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00007 Cys_knot, 1 hit
SMARTⁱ	View protein in SMART SM00068 GHB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00261 GLYCO_HORMONE_BETA_1, 1 hit PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01229-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN 
        60         70         80         90        100
TTICAGYCPT MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV 
       110        120        130        140 
SFPVALSCRC GPCRRSTSDC GGPKDHPLTC DHPQLSGLLF L

Length:141

Mass (Da):15,345

Last modified:November 1, 1995 - v3

Checksum:ⁱE411766253113F7C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	39	E → Q AA sequence (PubMed:1191677).Curated	1
Sequence conflictⁱ	76	Missing AA sequence (PubMed:1191677).Curated	1
Sequence conflictⁱ	132 – 135	HPQL → PQH AA sequence (PubMed:1191677).Curated	4

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034098	15	M → I. Corresponds to variant dbSNP:rs34247911Ensembl.	1
Natural variantⁱVAR_015672	18	A → T More effective in stimulating IP3 but not cAMP production. 1 PublicationCorresponds to variant dbSNP:rs5030775Ensembl.	1
Natural variantⁱVAR_014589	28	W → R1 PublicationCorresponds to variant dbSNP:rs1800447EnsemblClinVar.	1
Natural variantⁱVAR_014590	35	I → T1 PublicationCorresponds to variant dbSNP:rs34349826EnsemblClinVar.	1
Natural variantⁱVAR_003189	74	Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant dbSNP:rs5030773EnsemblClinVar.	1
Natural variantⁱVAR_015673	122	G → S May be implicated in female infertility. 1 PublicationCorresponds to variant dbSNP:rs5030774EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00264 Genomic DNA Translation: CAA25067.1 S71273 Genomic DNA Translation: AAD14960.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12748.1
PIRⁱ	I37994 UTHUB
NCBI Reference Sequences More...RefSeqⁱ	NP_000885.1, NM_000894.2
UniGeneⁱ	Hs.154704

Genome annotation databases

Ensemblⁱ	ENST00000221421; ENSP00000221421; ENSG00000104826
GeneIDⁱ	3972
KEGGⁱ	hsa:3972
UCSC genome browser More...UCSCⁱ	uc002plt.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01229	Lutropin subunit beta		GORGO		141	UniRef90_P01229
Lutropin subunit beta		PANTR		141
Luteinizing hormone beta polypeptide		HUMAN		141
Luteinizing hormone (Fragment)		PAPAN		24
Luteinizing hormone beta polypeptide		PANPA		141
+9

Protein	Similar proteins		Species	Score	Length	Source
P01229	Lutropin subunit beta		PANTR		141	UniRef50_P01229
Lutropin subunit beta		GORGO		141
Lutropin subunit beta		MOUSE		141
Lutropin subunit beta		RAT		141
Lutropin subunit beta (Fragment)		PHOSU		128
+72

Cross-referencesⁱ

Web resourcesⁱ

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Luteinizing hormone entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00264 Genomic DNA Translation: CAA25067.1 S71273 Genomic DNA Translation: AAD14960.1 Sequence problems.
CCDSⁱ	CCDS12748.1
PIRⁱ	I37994 UTHUB
RefSeqⁱ	NP_000885.1, NM_000894.2
UniGeneⁱ	Hs.154704

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1M92	model	-	A	1-141	[»]
ProteinModelPortalⁱ	P01229
SMRⁱ	P01229
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P01229, 4 interactors
STRINGⁱ	9606.ENSP00000221421

PTM databases

GlyConnectⁱ	350
UniCarbKBⁱ	P01229

Polymorphism and mutation databases

BioMutaⁱ	LHB
DMDMⁱ	1170834

Proteomic databases

PaxDbⁱ	P01229
PeptideAtlasⁱ	P01229
PRIDEⁱ	P01229
ProteomicsDBⁱ	51349

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3972
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000221421; ENSP00000221421; ENSG00000104826
GeneIDⁱ	3972
KEGGⁱ	hsa:3972
UCSCⁱ	uc002plt.4 human

Organism-specific databases

CTDⁱ	3972
DisGeNETⁱ	3972
EuPathDBⁱ	HostDB:ENSG00000104826.11
GeneCardsⁱ	LHB
HGNCⁱ	HGNC:6584 LHB
HPAⁱ	CAB022241 CAB022707 HPA038925
MalaCardsⁱ	LHB
MIMⁱ	152780 gene 228300 phenotype
neXtProtⁱ	NX_P01229
OpenTargetsⁱ	ENSG00000104826
Orphanetⁱ	325448 Leydig cell hypoplasia due to LHB deficiency
PharmGKBⁱ	PA30356
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J0DB Eukaryota ENOG4111ZSU LUCA
GeneTreeⁱ	ENSGT00390000010115
HOGENOMⁱ	HOG000116098
HOVERGENⁱ	HBG006698
InParanoidⁱ	P01229
KOⁱ	K08521
OMAⁱ	TICSGHC
PhylomeDBⁱ	P01229
TreeFamⁱ	TF332940

Enzyme and pathway databases

Reactomeⁱ	R-HSA-193048 Androgen biosynthesis R-HSA-193993 Mineralocorticoid biosynthesis R-HSA-209822 Glycoprotein hormones R-HSA-375281 Hormone ligand-binding receptors R-HSA-418555 G alpha (s) signalling events R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
SIGNORⁱ	P01229

Miscellaneous databases

GeneWikiⁱ	Luteinizing_hormone_beta_polypeptide
GenomeRNAiⁱ	3972
Protein Ontology More...PROⁱ	PR:P01229
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104826 Expressed in 107 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_LHB
ExpressionAtlasⁱ	P01229 baseline and differential
Genevisibleⁱ	P01229 HS

Family and domain databases

CDDⁱ	cd00069 GHB_like, 1 hit
Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR006208 Glyco_hormone_CN IPR001545 Gonadotropin_bsu IPR018245 Gonadotropin_bsu_CS
PANTHERⁱ	PTHR11515 PTHR11515, 1 hit
Pfamⁱ	View protein in Pfam PF00007 Cys_knot, 1 hit
SMARTⁱ	View protein in SMART SM00068 GHB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00261 GLYCO_HORMONE_BETA_1, 1 hit PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LSHB_HUMAN
Accessionⁱ	P01229Primary (citable) accession number: P01229 Secondary accession number(s): Q9UDI0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	November 1, 1995
	Last modified:	September 12, 2018
	This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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UniProtKB - P01229 (LSHB_HUMAN)

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Lutropin subunit beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ