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Entry version 200 (18 Sep 2019)
Sequence version 2 (01 Oct 1989)
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Protein

Follitropin subunit beta

Gene

FSHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-209822 Glycoprotein hormones
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P01225

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01225

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Follitropin subunit beta
Alternative name(s):
Follicle-stimulating hormone beta subunit
Short name:
FSH-B
Short name:
FSH-beta
Follitropin beta chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FSHB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3964 FSHB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
136530 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01225

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypogonadotropic hypogonadism 24 without anosmia (HH24)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH24 is characterized by primary amenorrhea in women, oligo or azoospermia with low to normal testosterone levels in men, and infertility.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03301569C → G in HH24. 1 PublicationCorresponds to variant dbSNP:rs5030776EnsemblClinVar.1

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi78T → E: Increased activation of the follicle-stimulating hormone signaling pathway. 1 Publication1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism

Organism-specific databases

DisGeNET

More...
DisGeNETi
2488

MalaCards human disease database

More...
MalaCardsi
FSHB
MIMi229070 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000131808

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
52901 Isolated follicle stimulating hormone deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28382

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P01225

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FSHB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
120552

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001171119 – 129Follitropin subunit betaAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi21 ↔ 69Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Disulfide bondi35 ↔ 84Combined sources1 Publication
Disulfide bondi38 ↔ 122Combined sources1 Publication
Glycosylationi42N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Disulfide bondi46 ↔ 100Combined sources1 Publication
Disulfide bondi50 ↔ 102Combined sources1 Publication
Disulfide bondi105 ↔ 112Combined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P01225

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01225

PeptideAtlas

More...
PeptideAtlasi
P01225

PRoteomics IDEntifications database

More...
PRIDEi
P01225

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51348

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
165

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01225

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01225

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P01225

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01225

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131808 Expressed in 38 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01225 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01225 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB023410
HPA069703

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CGAP012154EBI-1030645,EBI-718913

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108766, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-35604N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P01225

Protein interaction database and analysis system

More...
IntActi
P01225, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000416606

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01225

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01225

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWHY Eukaryota
ENOG4111ZSU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116098

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01225

KEGG Orthology (KO)

More...
KOi
K05250

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVEKEEC

Database of Orthologous Groups

More...
OrthoDBi
101221at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01225

TreeFam database of animal gene trees

More...
TreeFami
TF332940

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00069 GHB_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11515 PTHR11515, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00007 Cys_knot, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00068 GHB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01225-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLQFFFLF CCWKAICCNS CELTNITIAI EKEECRFCIS INTTWCAGYC
60 70 80 90 100
YTRDLVYKDP ARPKIQKTCT FKELVYETVR VPGCAHHADS LYTYPVATQC
110 120
HCGKCDSDST DCTVRGLGPS YCSFGEMKE
Length:129
Mass (Da):14,700
Last modified:October 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D2AF00DD76B8E2B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01204720S → I1 PublicationCorresponds to variant dbSNP:rs6170EnsemblClinVar.1
Natural variantiVAR_03301569C → G in HH24. 1 PublicationCorresponds to variant dbSNP:rs5030776EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M16647, M16646 Genomic DNA Translation: AAA52476.1
M24540, M24539 Genomic DNA Translation: AAA52470.1
M54914, M54913 Genomic DNA Translation: AAB02868.1
EF198021 Genomic DNA Translation: ABM88373.1
EF585489 mRNA Translation: ABQ57401.1
EF585490 Genomic DNA Translation: ABQ57402.1
EU081884 Genomic DNA Translation: ABU96749.1
EU081885 Genomic DNA Translation: ABU96750.1
AL358944 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68260.1
BC113488 mRNA Translation: AAI13489.1
BC113490 mRNA Translation: AAI13491.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7868.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40920 FTHUB

NCBI Reference Sequences

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RefSeqi
NP_000501.1, NM_000510.2
NP_001018090.1, NM_001018080.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254122; ENSP00000254122; ENSG00000131808
ENST00000417547; ENSP00000416606; ENSG00000131808
ENST00000533718; ENSP00000433424; ENSG00000131808

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2488

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2488

UCSC genome browser

More...
UCSCi
uc001msl.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Follicle-stimulating hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16647, M16646 Genomic DNA Translation: AAA52476.1
M24540, M24539 Genomic DNA Translation: AAA52470.1
M54914, M54913 Genomic DNA Translation: AAB02868.1
EF198021 Genomic DNA Translation: ABM88373.1
EF585489 mRNA Translation: ABQ57401.1
EF585490 Genomic DNA Translation: ABQ57402.1
EU081884 Genomic DNA Translation: ABU96749.1
EU081885 Genomic DNA Translation: ABU96750.1
AL358944 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68260.1
BC113488 mRNA Translation: AAI13489.1
BC113490 mRNA Translation: AAI13491.1
CCDSiCCDS7868.1
PIRiA40920 FTHUB
RefSeqiNP_000501.1, NM_000510.2
NP_001018090.1, NM_001018080.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FL7X-ray3.00B/D19-129[»]
1XWDX-ray2.92B/E19-129[»]
4AY9X-ray2.50B/E/H19-129[»]
4MQWX-ray2.90B/E/H19-129[»]
SMRiP01225
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108766, 1 interactor
DIPiDIP-35604N
ELMiP01225
IntActiP01225, 3 interactors
STRINGi9606.ENSP00000416606

PTM databases

GlyConnecti165
iPTMnetiP01225
PhosphoSitePlusiP01225
SwissPalmiP01225
UniCarbKBiP01225

Polymorphism and mutation databases

BioMutaiFSHB
DMDMi120552

Proteomic databases

MassIVEiP01225
PaxDbiP01225
PeptideAtlasiP01225
PRIDEiP01225
ProteomicsDBi51348

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2488

Genome annotation databases

EnsembliENST00000254122; ENSP00000254122; ENSG00000131808
ENST00000417547; ENSP00000416606; ENSG00000131808
ENST00000533718; ENSP00000433424; ENSG00000131808
GeneIDi2488
KEGGihsa:2488
UCSCiuc001msl.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2488
DisGeNETi2488

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FSHB
HGNCiHGNC:3964 FSHB
HPAiCAB023410
HPA069703
MalaCardsiFSHB
MIMi136530 gene
229070 phenotype
neXtProtiNX_P01225
OpenTargetsiENSG00000131808
Orphaneti52901 Isolated follicle stimulating hormone deficiency
PharmGKBiPA28382

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWHY Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00940000160051
HOGENOMiHOG000116098
InParanoidiP01225
KOiK05250
OMAiAVEKEEC
OrthoDBi101221at2759
PhylomeDBiP01225
TreeFamiTF332940

Enzyme and pathway databases

ReactomeiR-HSA-209822 Glycoprotein hormones
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
SABIO-RKiP01225
SIGNORiP01225

Miscellaneous databases

EvolutionaryTraceiP01225

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FSHB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2488
PharosiP01225

Protein Ontology

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PROi
PR:P01225

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000131808 Expressed in 38 organ(s), highest expression level in pituitary gland
ExpressionAtlasiP01225 baseline and differential
GenevisibleiP01225 HS

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSHB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01225
Secondary accession number(s): A2TF08, A5JVV3, Q14D61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1989
Last modified: September 18, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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