UniProtKB - P01221 (GLHA1_CYPCA)
Protein
Glycoprotein hormones alpha chain 1
Gene
cgaa
Organism
Cyprinus carpio (Common carp)
Status
Functioni
Involved in gametogenesis and steroidogenesis.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- protein heterodimerization activity Source: AgBase
Keywordsi
Molecular function | Hormone |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chain 1Alternative name(s): GTH-alpha Gonadotropin alpha chain 1 |
Gene namesi | Name:cgaa |
Organismi | Cyprinus carpio (Common carp) |
Taxonomic identifieri | 7962 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Cyprininae › Cyprinus |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 1 PublicationAdd BLAST | 23 | |
ChainiPRO_0000011665 | 24 – 118 | Glycoprotein hormones alpha chain 1Add BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 58 | By similarity | ||
Disulfide bondi | 37 ↔ 87 | By similarity | ||
Disulfide bondi | 55 ↔ 108 | By similarity | ||
Disulfide bondi | 59 ↔ 110 | By similarity | ||
Glycosylationi | 79 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Disulfide bondi | 86 ↔ 113 | By similarity | ||
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineCurated | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Heterodimer of an alpha and a beta chain.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- protein heterodimerization activity Source: AgBase
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalPhylogenomic databases
OrthoDBi | 1430707at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01221-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFWTRYAGAS ILLFFMLIRL GQLYPRNDMN NFGCEECKLK ENNIFSKPGA
60 70 80 90 100
PVYQCMGCCF SRAYPTPLRS KKTMLVPKNI TSEATCCVAK EVKRVLVNDV
110
KLVNHTDCHC STCYYHKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37379 mRNA Translation: AAA49209.1 X56497 Genomic DNA Translation: CAA39852.1 |
PIRi | S20607, UTCAA |
RefSeqi | XP_018951691.1, XM_019096146.1 |
Genome annotation databases
Ensembli | ENSCCRT00015084486; ENSCCRP00015081810; ENSCCRG00015033087 |
GeneIDi | 109081150 |
KEGGi | ccar:109081150 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37379 mRNA Translation: AAA49209.1 X56497 Genomic DNA Translation: CAA39852.1 |
PIRi | S20607, UTCAA |
RefSeqi | XP_018951691.1, XM_019096146.1 |
3D structure databases
SMRi | P01221 |
ModBasei | Search... |
Genome annotation databases
Ensembli | ENSCCRT00015084486; ENSCCRP00015081810; ENSCCRG00015033087 |
GeneIDi | 109081150 |
KEGGi | ccar:109081150 |
Organism-specific databases
CTDi | 1081 |
Phylogenomic databases
OrthoDBi | 1430707at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA1_CYPCA | |
Accessioni | P01221Primary (citable) accession number: P01221 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 95 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families