CGA

Functionⁱ

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity

GO - Molecular functionⁱ

follicle-stimulating hormone activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G protein-coupled receptor signaling pathway Source: UniProtKB
positive regulation of steroid biosynthetic process Source: UniProtKB
regulation of signaling receptor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycoprotein hormones alpha chain Alternative name(s): Anterior pituitary glycoprotein hormones common subunit alpha Follicle-stimulating hormone alpha chain Short name: FSH-alpha Follitropin alpha chain Luteinizing hormone alpha chain Short name: LSH-alpha Lutropin alpha chain Thyroid-stimulating hormone alpha chain Short name: TSH-alpha Thyrotropin alpha chain
Gene namesⁱ	Name:CGA
Organismⁱ	Equus caballus (Horse)
Taxonomic identifierⁱ	9796 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus
Proteomesⁱ	UP000002281 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Add BLAST		24
ChainⁱPRO_0000011639	25 – 120	Glycoprotein hormones alpha chainAdd BLAST		96

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	35 ↔ 59	By similarity
Disulfide bondⁱ	38 ↔ 88	By similarity
Disulfide bondⁱ	56 ↔ 110	By similarity
Disulfide bondⁱ	60 ↔ 112	By similarity
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	87 ↔ 115	By similarity
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

PTM databases

UniCarbKBⁱ	P01220

UniCarbKBⁱ

P01220

Interactionⁱ

Subunit structureⁱ

Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.By similarity

GO - Molecular functionⁱ

follicle-stimulating hormone activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01220
SMRⁱ	P01220
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycoprotein hormones subunit alpha family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

HOGENOMⁱ	HOG000232008
HOVERGENⁱ	HBG000452
InParanoidⁱ	P01220
KEGG Orthology (KO) More...KOⁱ	K08522

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000476 Glyco_hormone
PANTHERⁱ	PTHR11509 PTHR11509, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00236 Hormone_6, 1 hit
PRINTSⁱ	PR00274 GLYCOHORMONE
SMARTⁱ	View protein in SMART SM00067 GHA, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01220-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDYYRKHAAV ILATLSVFLH ILHSFPDGEF TTQDCPECKL RENKYFFKLG 
        60         70         80         90        100
VPIYQCKGCC FSRAYPTPAR SRKTMLVPKN ITSESTCCVA KAFIRVTVMG 
       110        120
NIKLENHTQC YCSTCYHHKI

Length:120

Mass (Da):13,809

Last modified:July 15, 1998 - v3

Checksum:ⁱ8A633823F93ACFA6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	43	N → D AA sequence (PubMed:670201).Curated	1
Sequence conflictⁱ	57	K → M AA sequence (PubMed:670201).Curated	1
Sequence conflictⁱ	94	I → T AA sequence (PubMed:670201).Curated	1
Sequence conflictⁱ	104	L → S AA sequence (PubMed:670201).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000200 mRNA Translation: BAA19068.1 M27462 mRNA Translation: AAA57252.1
PIRⁱ	A28576 TTHOA
NCBI Reference Sequences More...RefSeqⁱ	NP_001093233.1, NM_001099763.1 XP_005596847.1, XM_005596790.2 XP_005596848.1, XM_005596791.2
UniGeneⁱ	Eca.10683

Genome annotation databases

GeneIDⁱ	100034174
KEGGⁱ	ecb:100034174

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01220	Glycoprotein hormones alpha chain		HORSE		120	UniRef100_P01220

Protein	Similar proteins		Species	Score	Length	Source
P01220	Glycoprotein hormones alpha chain		EQUAS		120	UniRef90_P01220
Glycoprotein hormones alpha chain		EQUBU		120
Glycoprotein hormones alpha chain		HORSE		120
UPI0004BDB6FD		EQUPR		120
Glycoprotein hormones alpha chain		HORSE		116

Protein	Similar proteins		Species	Score	Length	Source
P01220	Glycoprotein hormones alpha chain		MACFA		120	UniRef50_Q9BEH3
Glycoprotein hormones alpha chain		MACMU		120
Glycoprotein hormones alpha chain		CALJA		120
Glycoprotein hormones alpha chain		CLAGA		116
Glycoprotein hormones alpha chain		ICTPU		116
+74

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000200 mRNA Translation: BAA19068.1 M27462 mRNA Translation: AAA57252.1
PIRⁱ	A28576 TTHOA
RefSeqⁱ	NP_001093233.1, NM_001099763.1 XP_005596847.1, XM_005596790.2 XP_005596848.1, XM_005596791.2
UniGeneⁱ	Eca.10683

3D structure databases

ProteinModelPortalⁱ	P01220
SMRⁱ	P01220
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

UniCarbKBⁱ	P01220

UniCarbKBⁱ

P01220

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	100034174
KEGGⁱ	ecb:100034174

Organism-specific databases

CTDⁱ	1081

CTDⁱ

1081

Phylogenomic databases

HOGENOMⁱ	HOG000232008
HOVERGENⁱ	HBG000452
InParanoidⁱ	P01220
KOⁱ	K08522

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000476 Glyco_hormone
PANTHERⁱ	PTHR11509 PTHR11509, 1 hit
Pfamⁱ	View protein in Pfam PF00236 Hormone_6, 1 hit
PRINTSⁱ	PR00274 GLYCOHORMONE
SMARTⁱ	View protein in SMART SM00067 GHA, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLHA_HORSE
Accessionⁱ	P01220Primary (citable) accession number: P01220
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 15, 1998
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniParc

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Supporting data

UniProtKB - P01220 (GLHA_HORSE)

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Glycoprotein hormones alpha chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ