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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:CGA
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001163925 – 120Glycoprotein hormones alpha chainAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi87 ↔ 115By similarity
Glycosylationi106N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

UniCarbKBiP01220

Interactioni

Subunit structurei

Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP01220
SMRiP01220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000232008
HOVERGENiHBG000452
InParanoidiP01220
KOiK08522

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01220-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYYRKHAAV ILATLSVFLH ILHSFPDGEF TTQDCPECKL RENKYFFKLG
60 70 80 90 100
VPIYQCKGCC FSRAYPTPAR SRKTMLVPKN ITSESTCCVA KAFIRVTVMG
110 120
NIKLENHTQC YCSTCYHHKI
Length:120
Mass (Da):13,809
Last modified:July 15, 1998 - v3
Checksum:i8A633823F93ACFA6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43N → D AA sequence (PubMed:670201).Curated1
Sequence conflicti57K → M AA sequence (PubMed:670201).Curated1
Sequence conflicti94I → T AA sequence (PubMed:670201).Curated1
Sequence conflicti104L → S AA sequence (PubMed:670201).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000200 mRNA Translation: BAA19068.1
M27462 mRNA Translation: AAA57252.1
PIRiA28576 TTHOA
RefSeqiNP_001093233.1, NM_001099763.1
XP_005596847.1, XM_005596790.2
XP_005596848.1, XM_005596791.2
UniGeneiEca.10683

Genome annotation databases

GeneIDi100034174
KEGGiecb:100034174

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000200 mRNA Translation: BAA19068.1
M27462 mRNA Translation: AAA57252.1
PIRiA28576 TTHOA
RefSeqiNP_001093233.1, NM_001099763.1
XP_005596847.1, XM_005596790.2
XP_005596848.1, XM_005596791.2
UniGeneiEca.10683

3D structure databases

ProteinModelPortaliP01220
SMRiP01220
ModBaseiSearch...
MobiDBiSearch...

PTM databases

UniCarbKBiP01220

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100034174
KEGGiecb:100034174

Organism-specific databases

CTDi1081

Phylogenomic databases

HOGENOMiHOG000232008
HOVERGENiHBG000452
InParanoidiP01220
KOiK08522

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLHA_HORSE
AccessioniPrimary (citable) accession number: P01220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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