UniProtKB - P01220 (GLHA_HORSE)
Protein
Glycoprotein hormones alpha chain
Gene
CGA
Organism
Equus caballus (Horse)
Status
Functioni
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity
GO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of steroid biosynthetic process Source: UniProtKB
- regulation of signaling receptor activity Source: UniProtKB
- thyroid hormone generation Source: GO_Central
Keywordsi
Molecular function | Hormone |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chainAlternative name(s): Anterior pituitary glycoprotein hormones common subunit alpha Follicle-stimulating hormone alpha chain Short name: FSH-alpha Follitropin alpha chain Luteinizing hormone alpha chain Short name: LSH-alpha Lutropin alpha chain Thyroid-stimulating hormone alpha chain Short name: TSH-alpha Thyrotropin alpha chain |
Gene namesi | Name:CGA |
Organismi | Equus caballus (Horse) |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
- follicle-stimulating hormone complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Add BLAST | 24 | |
ChainiPRO_0000011639 | 25 – 120 | Glycoprotein hormones alpha chainAdd BLAST | 96 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 59 | By similarity | ||
Disulfide bondi | 38 ↔ 88 | By similarity | ||
Disulfide bondi | 56 ↔ 110 | By similarity | ||
Disulfide bondi | 60 ↔ 112 | By similarity | ||
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 87 ↔ 115 | By similarity | ||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
By similarityGO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalPhylogenomic databases
InParanoidi | P01220 |
OrthoDBi | 1430707at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01220-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYYRKHAAV ILATLSVFLH ILHSFPDGEF TTQDCPECKL RENKYFFKLG
60 70 80 90 100
VPIYQCKGCC FSRAYPTPAR SRKTMLVPKN ITSESTCCVA KAFIRVTVMG
110 120
NIKLENHTQC YCSTCYHHKI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 43 | N → D AA sequence (PubMed:670201).Curated | 1 | |
Sequence conflicti | 57 | K → M AA sequence (PubMed:670201).Curated | 1 | |
Sequence conflicti | 94 | I → T AA sequence (PubMed:670201).Curated | 1 | |
Sequence conflicti | 104 | L → S AA sequence (PubMed:670201).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB000200 mRNA Translation: BAA19068.1 M27462 mRNA Translation: AAA57252.1 |
PIRi | A28576, TTHOA |
RefSeqi | NP_001093233.1, NM_001099763.1 XP_005596847.1, XM_005596790.2 XP_005596848.1, XM_005596791.2 |
Genome annotation databases
GeneIDi | 100034174 |
KEGGi | ecb:100034174 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB000200 mRNA Translation: BAA19068.1 M27462 mRNA Translation: AAA57252.1 |
PIRi | A28576, TTHOA |
RefSeqi | NP_001093233.1, NM_001099763.1 XP_005596847.1, XM_005596790.2 XP_005596848.1, XM_005596791.2 |
3D structure databases
SMRi | P01220 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 100034174 |
KEGGi | ecb:100034174 |
Organism-specific databases
CTDi | 1081 |
Phylogenomic databases
InParanoidi | P01220 |
OrthoDBi | 1430707at2759 |
Gene expression databases
ExpressionAtlasi | P01220, baseline |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA_HORSE | |
Accessioni | P01220Primary (citable) accession number: P01220 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 15, 1998 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families