UniProtKB - P01217 (GLHA_BOVIN)
Protein
Glycoprotein hormones alpha chain
Gene
CGA
Organism
Bos taurus (Bovine)
Status
Functioni
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity
GO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
GO - Biological processi
- cellular response to hormone stimulus Source: Ensembl
- developmental growth Source: Ensembl
- follicle-stimulating hormone secretion Source: Ensembl
- gonad development Source: Ensembl
- G protein-coupled receptor signaling pathway Source: UniProtKB
- luteinizing hormone secretion Source: Ensembl
- negative regulation of organ growth Source: Ensembl
- positive regulation of steroid biosynthetic process Source: UniProtKB
- regulation of signaling receptor activity Source: UniProtKB
- thyroid gland development Source: Ensembl
- thyroid hormone generation Source: GO_Central
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
Reactomei | R-BTA-193993, Mineralocorticoid biosynthesis R-BTA-209822, Glycoprotein hormones R-BTA-209968, Thyroxine biosynthesis R-BTA-375281, Hormone ligand-binding receptors R-BTA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-BTA-975578, Reactions specific to the complex N-glycan synthesis pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chainAlternative name(s): Anterior pituitary glycoprotein hormones common subunit alpha Follicle-stimulating hormone alpha chain Short name: FSH-alpha Follitropin alpha chain Luteinizing hormone alpha chain Short name: LSH-alpha Lutropin alpha chain Thyroid-stimulating hormone alpha chain Short name: TSH-alpha Thyrotropin alpha chain |
Gene namesi | Name:CGA |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:27257, CGA |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
- follicle-stimulating hormone complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000011633 | 25 – 120 | Glycoprotein hormones alpha chainAdd BLAST | 96 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 59 | By similarity | ||
Disulfide bondi | 38 ↔ 88 | By similarity | ||
Disulfide bondi | 56 ↔ 110 | By similarity | ||
Disulfide bondi | 60 ↔ 112 | By similarity | ||
GlycosylationiCAR_000035 | 67 | O-linked (GalNAc...) threonine | 1 | |
Glycosylationi | 80 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 87 ↔ 115 | |||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P01217 |
PTM databases
GlyConnecti | 164, 2 N-Linked glycans 193, 1 O-Linked glycan (1 site) 349, 6 N-Linked glycans 601, 37 N-Linked glycans |
iPTMneti | P01217 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000016138, Expressed in conceptus and 7 other tissues |
ExpressionAtlasi | P01217, baseline |
Interactioni
Subunit structurei
Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
By similarityGO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000021481 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S1PK, Eukaryota |
GeneTreei | ENSGT00390000012242 |
HOGENOMi | CLU_148106_0_0_1 |
InParanoidi | P01217 |
OMAi | STCYHHK |
OrthoDBi | 1430707at2759 |
TreeFami | TF332733 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01217-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYYRKYAAV ILAILSLFLQ ILHSFPDGEF TMQGCPECKL KENKYFSKPD
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG
110 120
NVRVENHTEC HCSTCYYHKS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | A → T in CAA24932 (PubMed:6688736).Curated | 1 | |
Sequence conflicti | 37 | E → Q AA sequence (PubMed:5101174).Curated | 1 | |
Sequence conflicti | 52 | P → A in CAA24932 (PubMed:6688736).Curated | 1 | |
Sequence conflicti | 84 – 87 | EATC → AZCT AA sequence (PubMed:5107231).Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00003, X00004 Genomic DNA Translation: CAA24907.1 X00050 mRNA Translation: CAA24932.1 |
PIRi | A93489, TTBOA |
RefSeqi | NP_776326.1, NM_173901.3 |
Genome annotation databases
Ensembli | ENSBTAT00000021481; ENSBTAP00000021481; ENSBTAG00000016138 ENSBTAT00000078886; ENSBTAP00000065256; ENSBTAG00000016138 |
GeneIDi | 280749 |
KEGGi | bta:280749 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00003, X00004 Genomic DNA Translation: CAA24907.1 X00050 mRNA Translation: CAA24932.1 |
PIRi | A93489, TTBOA |
RefSeqi | NP_776326.1, NM_173901.3 |
3D structure databases
SMRi | P01217 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000021481 |
PTM databases
GlyConnecti | 164, 2 N-Linked glycans 193, 1 O-Linked glycan (1 site) 349, 6 N-Linked glycans 601, 37 N-Linked glycans |
iPTMneti | P01217 |
Proteomic databases
PaxDbi | P01217 |
Genome annotation databases
Ensembli | ENSBTAT00000021481; ENSBTAP00000021481; ENSBTAG00000016138 ENSBTAT00000078886; ENSBTAP00000065256; ENSBTAG00000016138 |
GeneIDi | 280749 |
KEGGi | bta:280749 |
Organism-specific databases
CTDi | 1081 |
VGNCi | VGNC:27257, CGA |
Phylogenomic databases
eggNOGi | ENOG502S1PK, Eukaryota |
GeneTreei | ENSGT00390000012242 |
HOGENOMi | CLU_148106_0_0_1 |
InParanoidi | P01217 |
OMAi | STCYHHK |
OrthoDBi | 1430707at2759 |
TreeFami | TF332733 |
Enzyme and pathway databases
Reactomei | R-BTA-193993, Mineralocorticoid biosynthesis R-BTA-209822, Glycoprotein hormones R-BTA-209968, Thyroxine biosynthesis R-BTA-375281, Hormone ligand-binding receptors R-BTA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-BTA-975578, Reactions specific to the complex N-glycan synthesis pathway |
Gene expression databases
Bgeei | ENSBTAG00000016138, Expressed in conceptus and 7 other tissues |
ExpressionAtlasi | P01217, baseline |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA_BOVIN | |
Accessioni | P01217Primary (citable) accession number: P01217 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 23, 1986 | |
Last modified: | February 10, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families