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Protein

Glycoprotein hormones alpha chain

Gene

Cga

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity

Caution

PubMed:6177696 sequence was originally thought to originate from rat.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-193048 Androgen biosynthesis
R-MMU-193993 Mineralocorticoid biosynthesis
R-MMU-209822 Glycoprotein hormones
R-MMU-209968 Thyroxine biosynthesis
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-MMU-975578 Reactions specific to the complex N-glycan synthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:Cga
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88390 Cga

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001164825 – 120Glycoprotein hormones alpha chainAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi87 ↔ 115By similarity
Glycosylationi106N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01216
PeptideAtlasiP01216
PRIDEiP01216

PTM databases

iPTMnetiP01216
PhosphoSitePlusiP01216

Expressioni

Gene expression databases

BgeeiENSMUSG00000028298 Expressed in 42 organ(s), highest expression level in pituitary gland
CleanExiMM_CGA
ExpressionAtlasiP01216 baseline and differential
GenevisibleiP01216 MM

Interactioni

Subunit structurei

Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029975

Structurei

3D structure databases

ProteinModelPortaliP01216
SMRiP01216
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWI0 Eukaryota
ENOG4111Q75 LUCA
GeneTreeiENSGT00390000012242
HOGENOMiHOG000232008
HOVERGENiHBG000452
InParanoidiP01216
KOiK08522
OMAiDGEFTMQ
OrthoDBiEOG091G0TRG
PhylomeDBiP01216
TreeFamiTF332733

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01216-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYYRKYAAV ILVMLSMFLH ILHSLPDGDF IIQGCPECKL KENKYFSKLG
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG
110 120
NARVENHTEC HCSTCYYHKS
Length:120
Mass (Da):13,565
Last modified:July 21, 1986 - v1
Checksum:iF2FA2E4632716DBC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AVN2A2AVN2_MOUSE
Glycoprotein hormones alpha chain
Cga
117Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 6RK → KR in CAA24566 (PubMed:6177696).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00643 mRNA Translation: AAA96700.1
V01253 mRNA Translation: CAA24566.1
M22991 Genomic DNA No translation available.
M22992 Genomic DNA Translation: AAA99228.1
AF307151 mRNA Translation: AAG30279.1
BC087926 mRNA Translation: AAH87926.1
CCDSiCCDS18035.1
PIRiA31598 TTMSA
RefSeqiNP_034019.1, NM_009889.2
XP_006537649.1, XM_006537586.2
UniGeneiMm.1361

Genome annotation databases

EnsembliENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298
ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298
GeneIDi12640
KEGGimmu:12640
UCSCiuc008sgq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00643 mRNA Translation: AAA96700.1
V01253 mRNA Translation: CAA24566.1
M22991 Genomic DNA No translation available.
M22992 Genomic DNA Translation: AAA99228.1
AF307151 mRNA Translation: AAG30279.1
BC087926 mRNA Translation: AAH87926.1
CCDSiCCDS18035.1
PIRiA31598 TTMSA
RefSeqiNP_034019.1, NM_009889.2
XP_006537649.1, XM_006537586.2
UniGeneiMm.1361

3D structure databases

ProteinModelPortaliP01216
SMRiP01216
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029975

PTM databases

iPTMnetiP01216
PhosphoSitePlusiP01216

Proteomic databases

PaxDbiP01216
PeptideAtlasiP01216
PRIDEiP01216

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298
ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298
GeneIDi12640
KEGGimmu:12640
UCSCiuc008sgq.1 mouse

Organism-specific databases

CTDi1081
MGIiMGI:88390 Cga

Phylogenomic databases

eggNOGiENOG410IWI0 Eukaryota
ENOG4111Q75 LUCA
GeneTreeiENSGT00390000012242
HOGENOMiHOG000232008
HOVERGENiHBG000452
InParanoidiP01216
KOiK08522
OMAiDGEFTMQ
OrthoDBiEOG091G0TRG
PhylomeDBiP01216
TreeFamiTF332733

Enzyme and pathway databases

ReactomeiR-MMU-193048 Androgen biosynthesis
R-MMU-193993 Mineralocorticoid biosynthesis
R-MMU-209822 Glycoprotein hormones
R-MMU-209968 Thyroxine biosynthesis
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-MMU-975578 Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

PROiPR:P01216
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028298 Expressed in 42 organ(s), highest expression level in pituitary gland
CleanExiMM_CGA
ExpressionAtlasiP01216 baseline and differential
GenevisibleiP01216 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLHA_MOUSE
AccessioniPrimary (citable) accession number: P01216
Secondary accession number(s): P11963, Q5M8P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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