Cga

Functionⁱ

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity

Caution

PubMed:6177696 sequence was originally thought to originate from rat.Curated

GO - Molecular functionⁱ

follicle-stimulating hormone activity Source: UniProtKB
hormone activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hormone stimulus
Source: MGI
Inferred from mutant phenotypeⁱ
- 12114718
developmental growth
Source: MGI
Inferred from mutant phenotypeⁱ
- 12114718
follicle-stimulating hormone secretion
Source: MGI
Inferred from mutant phenotypeⁱ
- 12114718
gonad development
Source: MGI
Inferred from mutant phenotypeⁱ
- 12114718
G protein-coupled receptor signaling pathway Source: UniProtKB
luteinizing hormone secretion
Source: MGI
Inferred from mutant phenotypeⁱ
- 12114718
negative regulation of organ growth
Source: MGI
Inferred from mutant phenotypeⁱ
- 12114718
positive regulation of steroid biosynthetic process Source: UniProtKB
regulation of signaling receptor activity Source: UniProtKB
thyroid gland development
Source: MGI
Inferred from mutant phenotypeⁱ
- 12114718
thyroid hormone generation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12114718

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-MMU-193048 Androgen biosynthesis R-MMU-193993 Mineralocorticoid biosynthesis R-MMU-209822 Glycoprotein hormones R-MMU-209968 Thyroxine biosynthesis R-MMU-375281 Hormone ligand-binding receptors R-MMU-418555 G alpha (s) signalling events R-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-MMU-975578 Reactions specific to the complex N-glycan synthesis pathway

Reactomeⁱ

R-MMU-193048 Androgen biosynthesis
R-MMU-193993 Mineralocorticoid biosynthesis
R-MMU-209822 Glycoprotein hormones
R-MMU-209968 Thyroxine biosynthesis
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-MMU-975578 Reactions specific to the complex N-glycan synthesis pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycoprotein hormones alpha chain Alternative name(s): Anterior pituitary glycoprotein hormones common subunit alpha Follicle-stimulating hormone alpha chain Short name: FSH-alpha Follitropin alpha chain Luteinizing hormone alpha chain Short name: LSH-alpha Lutropin alpha chain Thyroid-stimulating hormone alpha chain Short name: TSH-alpha Thyrotropin alpha chain
Gene namesⁱ	Name:Cga
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:88390 Cga

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Add BLAST		24
ChainⁱPRO_0000011648	25 – 120	Glycoprotein hormones alpha chainAdd BLAST		96

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	35 ↔ 59	By similarity
Disulfide bondⁱ	38 ↔ 88	By similarity
Disulfide bondⁱ	56 ↔ 110	By similarity
Disulfide bondⁱ	60 ↔ 112	By similarity
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	87 ↔ 115	By similarity
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P01216
PeptideAtlas More...PeptideAtlasⁱ	P01216
PRIDEⁱ	P01216

PTM databases

iPTMnetⁱ	P01216
PhosphoSitePlusⁱ	P01216

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028298 Expressed in 42 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_CGA
ExpressionAtlasⁱ	P01216 baseline and differential
Genevisibleⁱ	P01216 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.By similarity

GO - Molecular functionⁱ

follicle-stimulating hormone activity Source: UniProtKB
hormone activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000029975

STRINGⁱ

10090.ENSMUSP00000029975

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01216
SMRⁱ	P01216
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycoprotein hormones subunit alpha family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IWI0 Eukaryota ENOG4111Q75 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012242
HOGENOMⁱ	HOG000232008
HOVERGENⁱ	HBG000452
InParanoidⁱ	P01216
KEGG Orthology (KO) More...KOⁱ	K08522
OMAⁱ	DGEFTMQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TRG
PhylomeDBⁱ	P01216
TreeFamⁱ	TF332733

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000476 Glyco_hormone
PANTHERⁱ	PTHR11509 PTHR11509, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00236 Hormone_6, 1 hit
PRINTSⁱ	PR00274 GLYCOHORMONE
SMARTⁱ	View protein in SMART SM00067 GHA, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P01216-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDYYRKYAAV ILVMLSMFLH ILHSLPDGDF IIQGCPECKL KENKYFSKLG 
        60         70         80         90        100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG 
       110        120
NARVENHTEC HCSTCYYHKS

Length:120

Mass (Da):13,565

Last modified:July 21, 1986 - v1

Checksum:ⁱF2FA2E4632716DBC

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2AVN2	A2AVN2_MOUSE		Glycoprotein hormones alpha chain Glycoprotein hormones alpha chain	Cga	117	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	5 – 6	RK → KR in CAA24566 (PubMed:6177696).Curated		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00643 mRNA Translation: AAA96700.1 V01253 mRNA Translation: CAA24566.1 M22991 Genomic DNA No translation available. M22992 Genomic DNA Translation: AAA99228.1 AF307151 mRNA Translation: AAG30279.1 BC087926 mRNA Translation: AAH87926.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18035.1
PIRⁱ	A31598 TTMSA
NCBI Reference Sequences More...RefSeqⁱ	NP_034019.1, NM_009889.2 XP_006537649.1, XM_006537586.2
UniGeneⁱ	Mm.1361

Genome annotation databases

Ensemblⁱ	ENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298 ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298
GeneIDⁱ	12640
KEGGⁱ	mmu:12640
UCSC genome browser More...UCSCⁱ	uc008sgq.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01216	Glycoprotein hormones alpha chain		MOUSE		120	UniRef100_P01216
Glycoprotein hormones alpha chain (Fragment)		MOUSE		117

Protein	Similar proteins		Species	Score	Length	Source
P01216	Glycoprotein hormones alpha chain		PIG		120	UniRef90_P01216
Glycoprotein hormones alpha chain		PANTA		120
Glycoprotein hormones alpha chain		RABIT		120
Glycoprotein hormones alpha chain		SHEEP		120
Glycoprotein hormones alpha chain		MESAU		120
+81

Protein	Similar proteins		Species	Score	Length	Source
P01216	Glycoprotein hormones alpha chain		MESAU		120	UniRef50_P01216
Glycoprotein hormones alpha chain		FELCA		120
Glycoprotein hormones alpha chain		PIG		120
Glycoprotein hormones alpha chain		AILFU		120
Glycoprotein hormones alpha chain		MONDO		120
+203

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00643 mRNA Translation: AAA96700.1 V01253 mRNA Translation: CAA24566.1 M22991 Genomic DNA No translation available. M22992 Genomic DNA Translation: AAA99228.1 AF307151 mRNA Translation: AAG30279.1 BC087926 mRNA Translation: AAH87926.1
CCDSⁱ	CCDS18035.1
PIRⁱ	A31598 TTMSA
RefSeqⁱ	NP_034019.1, NM_009889.2 XP_006537649.1, XM_006537586.2
UniGeneⁱ	Mm.1361

3D structure databases

ProteinModelPortalⁱ	P01216
SMRⁱ	P01216
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000029975

STRINGⁱ

10090.ENSMUSP00000029975

PTM databases

iPTMnetⁱ	P01216
PhosphoSitePlusⁱ	P01216

Proteomic databases

PaxDbⁱ	P01216
PeptideAtlasⁱ	P01216
PRIDEⁱ	P01216

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298 ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298
GeneIDⁱ	12640
KEGGⁱ	mmu:12640
UCSCⁱ	uc008sgq.1 mouse

Organism-specific databases

CTDⁱ	1081
MGIⁱ	MGI:88390 Cga

Phylogenomic databases

eggNOGⁱ	ENOG410IWI0 Eukaryota ENOG4111Q75 LUCA
GeneTreeⁱ	ENSGT00390000012242
HOGENOMⁱ	HOG000232008
HOVERGENⁱ	HBG000452
InParanoidⁱ	P01216
KOⁱ	K08522
OMAⁱ	DGEFTMQ
OrthoDBⁱ	EOG091G0TRG
PhylomeDBⁱ	P01216
TreeFamⁱ	TF332733

Enzyme and pathway databases

Reactomeⁱ	R-MMU-193048 Androgen biosynthesis R-MMU-193993 Mineralocorticoid biosynthesis R-MMU-209822 Glycoprotein hormones R-MMU-209968 Thyroxine biosynthesis R-MMU-375281 Hormone ligand-binding receptors R-MMU-418555 G alpha (s) signalling events R-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-MMU-975578 Reactions specific to the complex N-glycan synthesis pathway

Reactomeⁱ

R-MMU-193048 Androgen biosynthesis
R-MMU-193993 Mineralocorticoid biosynthesis
R-MMU-209822 Glycoprotein hormones
R-MMU-209968 Thyroxine biosynthesis
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-MMU-975578 Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P01216
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028298 Expressed in 42 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_CGA
ExpressionAtlasⁱ	P01216 baseline and differential
Genevisibleⁱ	P01216 MM

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000476 Glyco_hormone
PANTHERⁱ	PTHR11509 PTHR11509, 1 hit
Pfamⁱ	View protein in Pfam PF00236 Hormone_6, 1 hit
PRINTSⁱ	PR00274 GLYCOHORMONE
SMARTⁱ	View protein in SMART SM00067 GHA, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLHA_MOUSE
Accessionⁱ	P01216Primary (citable) accession number: P01216 Secondary accession number(s): P11963, Q5M8P4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01216 (GLHA_MOUSE)

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Glycoprotein hormones alpha chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ