UniProtKB - P01216 (GLHA_MOUSE)
Protein
Glycoprotein hormones alpha chain
Gene
Cga
Organism
Mus musculus (Mouse)
Status
Functioni
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.By similarity
Caution
PubMed:6177696 sequence was originally thought to originate from rat.Curated
GO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
- hormone activity Source: MGI
GO - Biological processi
- cellular response to hormone stimulus Source: MGI
- developmental growth Source: MGI
- follicle-stimulating hormone secretion Source: MGI
- gonad development Source: MGI
- G protein-coupled receptor signaling pathway Source: UniProtKB
- luteinizing hormone secretion Source: MGI
- negative regulation of organ growth Source: MGI
- positive regulation of steroid biosynthetic process Source: UniProtKB
- regulation of signaling receptor activity Source: UniProtKB
- thyroid gland development Source: MGI
- thyroid hormone generation Source: MGI
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
Reactomei | R-MMU-193048, Androgen biosynthesis R-MMU-193993, Mineralocorticoid biosynthesis R-MMU-209822, Glycoprotein hormones R-MMU-209968, Thyroxine biosynthesis R-MMU-375281, Hormone ligand-binding receptors R-MMU-418555, G alpha (s) signalling events R-MMU-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-MMU-975578, Reactions specific to the complex N-glycan synthesis pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chainAlternative name(s): Anterior pituitary glycoprotein hormones common subunit alpha Follicle-stimulating hormone alpha chain Short name: FSH-alpha Follitropin alpha chain Luteinizing hormone alpha chain Short name: LSH-alpha Lutropin alpha chain Thyroid-stimulating hormone alpha chain Short name: TSH-alpha Thyrotropin alpha chain |
Gene namesi | Name:Cga |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88390, Cga |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
- follicle-stimulating hormone complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Add BLAST | 24 | |
ChainiPRO_0000011648 | 25 – 120 | Glycoprotein hormones alpha chainAdd BLAST | 96 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 59 | By similarity | ||
Disulfide bondi | 38 ↔ 88 | By similarity | ||
Disulfide bondi | 56 ↔ 110 | By similarity | ||
Disulfide bondi | 60 ↔ 112 | By similarity | ||
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 87 ↔ 115 | By similarity | ||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P01216 |
PeptideAtlasi | P01216 |
PRIDEi | P01216 |
ProteomicsDBi | 268832 |
PTM databases
GlyGeni | P01216, 2 sites |
iPTMneti | P01216 |
PhosphoSitePlusi | P01216 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028298, Expressed in pituitary gland and 50 other tissues |
ExpressionAtlasi | P01216, baseline and differential |
Genevisiblei | P01216, MM |
Interactioni
Subunit structurei
Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
By similarityGO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
- hormone activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000029975 |
Miscellaneous databases
RNActi | P01216, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S1PK, Eukaryota |
GeneTreei | ENSGT00390000012242 |
HOGENOMi | CLU_148106_0_0_1 |
InParanoidi | P01216 |
OMAi | STCYHHK |
OrthoDBi | 1430707at2759 |
PhylomeDBi | P01216 |
TreeFami | TF332733 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P01216-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYYRKYAAV ILVMLSMFLH ILHSLPDGDF IIQGCPECKL KENKYFSKLG
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG
110 120
NARVENHTEC HCSTCYYHKS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2AVN2 | A2AVN2_MOUSE | Glycoprotein hormones alpha chain | Cga | 117 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 – 6 | RK → KR in CAA24566 (PubMed:6177696).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00643 mRNA Translation: AAA96700.1 V01253 mRNA Translation: CAA24566.1 M22991 Genomic DNA No translation available. M22992 Genomic DNA Translation: AAA99228.1 AF307151 mRNA Translation: AAG30279.1 BC087926 mRNA Translation: AAH87926.1 |
CCDSi | CCDS18035.1 |
PIRi | A31598, TTMSA |
RefSeqi | NP_034019.1, NM_009889.2 XP_006537649.1, XM_006537586.2 |
Genome annotation databases
Ensembli | ENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298 ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298 |
GeneIDi | 12640 |
KEGGi | mmu:12640 |
UCSCi | uc008sgq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00643 mRNA Translation: AAA96700.1 V01253 mRNA Translation: CAA24566.1 M22991 Genomic DNA No translation available. M22992 Genomic DNA Translation: AAA99228.1 AF307151 mRNA Translation: AAG30279.1 BC087926 mRNA Translation: AAH87926.1 |
CCDSi | CCDS18035.1 |
PIRi | A31598, TTMSA |
RefSeqi | NP_034019.1, NM_009889.2 XP_006537649.1, XM_006537586.2 |
3D structure databases
SMRi | P01216 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000029975 |
PTM databases
GlyGeni | P01216, 2 sites |
iPTMneti | P01216 |
PhosphoSitePlusi | P01216 |
Proteomic databases
PaxDbi | P01216 |
PeptideAtlasi | P01216 |
PRIDEi | P01216 |
ProteomicsDBi | 268832 |
Protocols and materials databases
Antibodypediai | 18627, 1486 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298 ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298 |
GeneIDi | 12640 |
KEGGi | mmu:12640 |
UCSCi | uc008sgq.1, mouse |
Organism-specific databases
CTDi | 1081 |
MGIi | MGI:88390, Cga |
Phylogenomic databases
eggNOGi | ENOG502S1PK, Eukaryota |
GeneTreei | ENSGT00390000012242 |
HOGENOMi | CLU_148106_0_0_1 |
InParanoidi | P01216 |
OMAi | STCYHHK |
OrthoDBi | 1430707at2759 |
PhylomeDBi | P01216 |
TreeFami | TF332733 |
Enzyme and pathway databases
Reactomei | R-MMU-193048, Androgen biosynthesis R-MMU-193993, Mineralocorticoid biosynthesis R-MMU-209822, Glycoprotein hormones R-MMU-209968, Thyroxine biosynthesis R-MMU-375281, Hormone ligand-binding receptors R-MMU-418555, G alpha (s) signalling events R-MMU-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-MMU-975578, Reactions specific to the complex N-glycan synthesis pathway |
Miscellaneous databases
BioGRID-ORCSi | 12640, 2 hits in 52 CRISPR screens |
ChiTaRSi | Chga, mouse |
PROi | PR:P01216 |
RNActi | P01216, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028298, Expressed in pituitary gland and 50 other tissues |
ExpressionAtlasi | P01216, baseline and differential |
Genevisiblei | P01216, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA_MOUSE | |
Accessioni | P01216Primary (citable) accession number: P01216 Secondary accession number(s): P11963, Q5M8P4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families