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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • follicle-stimulating hormone activity Source: UniProtKB
  • hormone activity Source: AgBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193048 Androgen biosynthesis
R-HSA-193993 Mineralocorticoid biosynthesis
R-HSA-209822 Glycoprotein hormones
R-HSA-209968 Thyroxine biosynthesis
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P01215

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01215

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Choriogonadotropin alpha chain
Chorionic gonadotrophin subunit alpha
Short name:
CG-alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CGA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135346.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1885 CGA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
118850 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01215

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi76N → D: Increases from 1 to 3 the number of FSH binding a single FSHR receptor. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1081

Open Targets

More...
OpenTargetsi
ENSG00000135346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26433

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2146305

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CGA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121312

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 244 PublicationsAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001164025 – 116Glycoprotein hormones alpha chainAdd BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 55Combined sources3 Publications
Disulfide bondi34 ↔ 84Combined sources3 Publications
Disulfide bondi52 ↔ 106Combined sources3 Publications
Disulfide bondi56 ↔ 108Combined sources3 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00003676N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Disulfide bondi83 ↔ 111Combined sources3 Publications
GlycosylationiCAR_000037102N-linked (GlcNAc...) asparagineCombined sources2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P01215

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01215

PeptideAtlas

More...
PeptideAtlasi
P01215

PRoteomics IDEntifications database

More...
PRIDEi
P01215

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51346

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
165
194
88

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01215

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01215

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01215

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135346 Expressed in 91 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_CGA

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01215 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01215 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB023350
HPA029698

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FSHBP012254EBI-718913,EBI-1030645

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107507, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-6182N

Protein interaction database and analysis system

More...
IntActi
P01215, 3 interactors

Molecular INTeraction database

More...
MINTi
P01215

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358595

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DZ7NMR-A25-116[»]
1E9JNMR-A25-116[»]
1FL7X-ray3.00A/C25-116[»]
1HCNX-ray2.60A25-116[»]
1HD4NMR-A25-116[»]
1HRPX-ray3.00A25-116[»]
1QFWX-ray3.50A25-116[»]
1XULmodel-A25-116[»]
1XWDX-ray2.92A/D25-116[»]
4AY9X-ray2.50A/D/G25-116[»]
4MQWX-ray2.90A/D/G25-116[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01215

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01215

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01215

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWI0 Eukaryota
ENOG4111Q75 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232008

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000452

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01215

KEGG Orthology (KO)

More...
KOi
K08522

Database of Orthologous Groups

More...
OrthoDBi
913381at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01215

TreeFam database of animal gene trees

More...
TreeFami
TF332733

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone

The PANTHER Classification System

More...
PANTHERi
PTHR11509 PTHR11509, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00236 Hormone_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00274 GLYCOHORMONE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00067 GHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P01215-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL
60 70 80 90 100
QCMGCCFSRA YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV
110
ENHTACHCST CYYHKS
Length:116
Mass (Da):13,075
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0623CD8CC90CFCD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYZ4A0A087WYZ4_HUMAN
Glycoprotein hormones alpha chain
CGA
147Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SGA7A0A0D9SGA7_HUMAN
Glycoprotein hormones alpha chain
CGA hCG_33165
101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFJ6A0A0D9SFJ6_HUMAN
Glycoprotein hormones alpha chain
CGA
62Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2F0A0A0R4J2F0_HUMAN
Glycoprotein hormones alpha chain
CGA
116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29Q → E AA sequence (PubMed:1158880).Curated1
Sequence conflicti108 – 109CS → SC AA sequence (PubMed:890569).Curated2
Sequence conflicti108 – 109CS → SC AA sequence (PubMed:5065401).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J00152, J00150, J00151 Genomic DNA Translation: AAD13690.1
S70585, S70583, S70584 Genomic DNA Translation: AAB30827.1
BC020782 mRNA Translation: AAH20782.1
BC055080 mRNA Translation: AAH55080.1
V00518 mRNA Translation: CAA23777.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5007.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A93213 TTHUAP

NCBI Reference Sequences

More...
RefSeqi
NP_000726.1, NM_000735.3
NP_001239312.1, NM_001252383.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.119689

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000627148; ENSP00000486024; ENSG00000135346

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1081

UCSC genome browser

More...
UCSCi
uc063pyi.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Proteic grace - Issue 77 of December 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00152, J00150, J00151 Genomic DNA Translation: AAD13690.1
S70585, S70583, S70584 Genomic DNA Translation: AAB30827.1
BC020782 mRNA Translation: AAH20782.1
BC055080 mRNA Translation: AAH55080.1
V00518 mRNA Translation: CAA23777.1
CCDSiCCDS5007.1
PIRiA93213 TTHUAP
RefSeqiNP_000726.1, NM_000735.3
NP_001239312.1, NM_001252383.1
UniGeneiHs.119689

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DZ7NMR-A25-116[»]
1E9JNMR-A25-116[»]
1FL7X-ray3.00A/C25-116[»]
1HCNX-ray2.60A25-116[»]
1HD4NMR-A25-116[»]
1HRPX-ray3.00A25-116[»]
1QFWX-ray3.50A25-116[»]
1XULmodel-A25-116[»]
1XWDX-ray2.92A/D25-116[»]
4AY9X-ray2.50A/D/G25-116[»]
4MQWX-ray2.90A/D/G25-116[»]
ProteinModelPortaliP01215
SMRiP01215
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107507, 6 interactors
DIPiDIP-6182N
IntActiP01215, 3 interactors
MINTiP01215
STRINGi9606.ENSP00000358595

Chemistry databases

ChEMBLiCHEMBL2146305

PTM databases

GlyConnecti165
194
88
iPTMnetiP01215
PhosphoSitePlusiP01215
UniCarbKBiP01215

Polymorphism and mutation databases

BioMutaiCGA
DMDMi121312

Proteomic databases

jPOSTiP01215
PaxDbiP01215
PeptideAtlasiP01215
PRIDEiP01215
ProteomicsDBi51346

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1081
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000627148; ENSP00000486024; ENSG00000135346
GeneIDi1081
KEGGihsa:1081
UCSCiuc063pyi.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1081
DisGeNETi1081
EuPathDBiHostDB:ENSG00000135346.8

GeneCards: human genes, protein and diseases

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GeneCardsi
CGA
HGNCiHGNC:1885 CGA
HPAiCAB023350
HPA029698
MIMi118850 gene
neXtProtiNX_P01215
OpenTargetsiENSG00000135346
PharmGKBiPA26433

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IWI0 Eukaryota
ENOG4111Q75 LUCA
GeneTreeiENSGT00390000012242
HOGENOMiHOG000232008
HOVERGENiHBG000452
InParanoidiP01215
KOiK08522
OrthoDBi913381at2759
PhylomeDBiP01215
TreeFamiTF332733

Enzyme and pathway databases

ReactomeiR-HSA-193048 Androgen biosynthesis
R-HSA-193993 Mineralocorticoid biosynthesis
R-HSA-209822 Glycoprotein hormones
R-HSA-209968 Thyroxine biosynthesis
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway
SABIO-RKiP01215
SIGNORiP01215

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CGA human
EvolutionaryTraceiP01215

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Chorionic_gonadotropin_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1081

Protein Ontology

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PROi
PR:P01215

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135346 Expressed in 91 organ(s), highest expression level in placenta
CleanExiHS_CGA
ExpressionAtlasiP01215 baseline and differential
GenevisibleiP01215 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLHA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01215
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 16, 2019
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
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