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Protein

Proenkephalin-A

Gene

PENK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • neuropeptide hormone activity Source: ProtInc
  • opioid peptide activity Source: UniProtKB-KW
  • opioid receptor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndorphin, Neuropeptide, Opioid peptide

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-418594 G alpha (i) signalling events
R-HSA-8957275 Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01210

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.89.1.2 the dynorphin channel-forming neuropeptide (dynorphin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 8 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PENK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000181195.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8831 PENK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
131330 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01210

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5179

Open Targets

More...
OpenTargetsi
ENSG00000181195

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33176

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PENK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
129770

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000824225 – 97SynenkephalinAdd BLAST73
PeptideiPRO_0000008243100 – 104Met-enkephalin5
PeptideiPRO_0000008244107 – 111Met-enkephalin5
PeptideiPRO_0000377691114 – 133PENK(114-133)By similarityAdd BLAST20
PeptideiPRO_0000008246136 – 140Met-enkephalin5
PeptideiPRO_0000377692143 – 183PENK(143-183)By similarityAdd BLAST41
PeptideiPRO_0000008248186 – 193Met-enkephalin-Arg-Gly-Leu8
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000008249196 – 207Add BLAST12
PeptideiPRO_0000008250210 – 214Met-enkephalin5
PropeptideiPRO_0000008251217 – 227Add BLAST11
PeptideiPRO_0000008252230 – 234Leu-enkephalin5
PeptideiPRO_0000377693237 – 258PENK(237-258)By similarityAdd BLAST22
PeptideiPRO_0000008254261 – 267Met-enkephalin-Arg-Phe7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26 ↔ 481 Publication
Disulfide bondi30 ↔ 521 Publication
Disulfide bondi33 ↔ 651 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01210

PeptideAtlas

More...
PeptideAtlasi
P01210

PRoteomics IDEntifications database

More...
PRIDEi
P01210

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51344

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01210

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01210

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01210

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181195 Expressed in 187 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

More...
CleanExi
HS_PENK

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01210 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01210 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016390
HPA013138

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
OPRM1P353723EBI-6656055,EBI-2624570

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111205, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P01210, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000324248

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PLWNMR-A100-104[»]
1PLXNMR-A100-104[»]
2LWCNMR-A261-265[»]
5E33X-ray1.84B261-265[»]
5E3AX-ray2.05B230-234[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P01210

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01210

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01210

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJUY Eukaryota
ENOG4110ZYD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063761

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013003

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000063

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01210

KEGG Orthology (KO)

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KOi
K18832

Identification of Orthologs from Complete Genome Data

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OMAi
FMKKDAE

Database of Orthologous Groups

More...
OrthoDBi
1149395at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01210

TreeFam database of animal gene trees

More...
TreeFami
TF332620

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006024 Opioid_neupept
IPR000703 Proenkphlin_A

The PANTHER Classification System

More...
PANTHERi
PTHR11438 PTHR11438, 1 hit
PTHR11438:SF3 PTHR11438:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01160 Opiods_neuropep, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01028 OPIOIDPRCRSR
PR01029 PENKAPRCRSR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01252 OPIOIDS_PRECURSOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P01210-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADINFLACVM
60 70 80 90 100
ECEGKLPSLK IWETCKELLQ LSKPELPQDG TSTLRENSKP EESHLLAKRY
110 120 130 140 150
GGFMKRYGGF MKKMDELYPM EPEEEANGSE ILAKRYGGFM KKDAEEDDSL
160 170 180 190 200
ANSSDLLKEL LETGDNRERS HHQDGSDNEE EVSKRYGGFM RGLKRSPQLE
210 220 230 240 250
DEAKELQKRY GGFMRRVGRP EWWMDYQKRY GGFLKRFAEA LPSDEEGESY
260
SKEVPEMEKR YGGFMRF
Length:267
Mass (Da):30,787
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4189BA600C3FC8EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFR1E5RFR1_HUMAN
Proenkephalin-A
PENK
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIP6E5RIP6_HUMAN
Proenkephalin-A
PENK
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBT5H0YBT5_HUMAN
Proenkephalin-A
PENK
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ72E5RJ72_HUMAN
Proenkephalin-A
PENK
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119P → S in CAG46627 (Ref. 4) Curated1
Sequence conflicti152N → I in CAG46607 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04893583T → N. Corresponds to variant dbSNP:rs11998459Ensembl.1
Natural variantiVAR_014584247G → D. Corresponds to variant dbSNP:rs1800567Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00509 Genomic DNA Translation: CAA23767.1
J00123, J00122 Genomic DNA Translation: AAB59409.1
AK314908 mRNA Translation: BAG37420.1
CR541808 mRNA Translation: CAG46607.1
CR541828 mRNA Translation: CAG46627.1
CH471068 Genomic DNA Translation: EAW86785.1
BC032505 mRNA Translation: AAH32505.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6168.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A93278 EQHUA

NCBI Reference Sequences

More...
RefSeqi
NP_001129162.1, NM_001135690.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.339831

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314922; ENSP00000324248; ENSG00000181195
ENST00000451791; ENSP00000400894; ENSG00000181195

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5179

UCSC genome browser

More...
UCSCi
uc003xsz.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00509 Genomic DNA Translation: CAA23767.1
J00123, J00122 Genomic DNA Translation: AAB59409.1
AK314908 mRNA Translation: BAG37420.1
CR541808 mRNA Translation: CAG46607.1
CR541828 mRNA Translation: CAG46627.1
CH471068 Genomic DNA Translation: EAW86785.1
BC032505 mRNA Translation: AAH32505.1
CCDSiCCDS6168.1
PIRiA93278 EQHUA
RefSeqiNP_001129162.1, NM_001135690.2
UniGeneiHs.339831

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PLWNMR-A100-104[»]
1PLXNMR-A100-104[»]
2LWCNMR-A261-265[»]
5E33X-ray1.84B261-265[»]
5E3AX-ray2.05B230-234[»]
ProteinModelPortaliP01210
SMRiP01210
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111205, 8 interactors
IntActiP01210, 3 interactors
STRINGi9606.ENSP00000324248

Protein family/group databases

TCDBi1.C.89.1.2 the dynorphin channel-forming neuropeptide (dynorphin) family

PTM databases

iPTMnetiP01210
PhosphoSitePlusiP01210

Polymorphism and mutation databases

BioMutaiPENK
DMDMi129770

Proteomic databases

PaxDbiP01210
PeptideAtlasiP01210
PRIDEiP01210
ProteomicsDBi51344

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5179
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314922; ENSP00000324248; ENSG00000181195
ENST00000451791; ENSP00000400894; ENSG00000181195
GeneIDi5179
KEGGihsa:5179
UCSCiuc003xsz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5179
DisGeNETi5179
EuPathDBiHostDB:ENSG00000181195.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PENK
HGNCiHGNC:8831 PENK
HPAiCAB016390
HPA013138
MIMi131330 gene
neXtProtiNX_P01210
OpenTargetsiENSG00000181195
PharmGKBiPA33176

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJUY Eukaryota
ENOG4110ZYD LUCA
GeneTreeiENSGT00530000063761
HOGENOMiHOG000013003
HOVERGENiHBG000063
InParanoidiP01210
KOiK18832
OMAiFMKKDAE
OrthoDBi1149395at2759
PhylomeDBiP01210
TreeFamiTF332620

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-418594 G alpha (i) signalling events
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP01210

Miscellaneous databases

EvolutionaryTraceiP01210

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5179
PMAP-CutDBiP01210

Protein Ontology

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PROi
PR:P01210

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000181195 Expressed in 187 organ(s), highest expression level in caudate nucleus
CleanExiHS_PENK
ExpressionAtlasiP01210 baseline and differential
GenevisibleiP01210 HS

Family and domain databases

InterProiView protein in InterPro
IPR006024 Opioid_neupept
IPR000703 Proenkphlin_A
PANTHERiPTHR11438 PTHR11438, 1 hit
PTHR11438:SF3 PTHR11438:SF3, 1 hit
PfamiView protein in Pfam
PF01160 Opiods_neuropep, 1 hit
PRINTSiPR01028 OPIOIDPRCRSR
PR01029 PENKAPRCRSR
PROSITEiView protein in PROSITE
PS01252 OPIOIDS_PRECURSOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPENK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01210
Secondary accession number(s): B2RC23, Q6FHC6, Q6FHE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 16, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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