Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - P01210 (PENK_HUMAN)

Entry version 183 (23 Feb 2022)
Sequence version 1 (21 Jul 1986)
Previous versions | rss
Add a publicationFeedback
Protein

Proenkephalin-A

Gene

PENK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.

Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.

Increases glutamate release in the striatum and decreases GABA concentration in the striatum.

By similarity

Increases glutamate release in the striatum.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndorphin, Neuropeptide, Opioid peptide

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01210

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276, Peptide ligand-binding receptors
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-418594, G alpha (i) signalling events
R-HSA-8957275, Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P01210

SIGNOR Signaling Network Open Resource

More...SIGNORi		P01210

Protein family/group databases

Transport Classification Database

More...TCDBi		1.C.89.1.2, the dynorphin channel-forming neuropeptide (dynorphin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proenkephalin-ACurated
Cleaved into the following 8 chains:
Synenkephalin
Met-enkephalin
Alternative name(s):
Opioid growth factor
Short name:
OGF
PENK(114-133)
PENK(143-183)
Met-enkephalin-Arg-Gly-Leu
Leu-enkephalin
PENK(237-258)
Met-enkephalin-Arg-Phe
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PENKImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8831, PENK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		131330, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01210

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000181195

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5179

Open Targets

More...OpenTargetsi		ENSG00000181195

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33176

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01210, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PENK

Domain mapping of disease mutations (DMDM)

More...DMDMi		129770

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000824225 – 97SynenkephalinAdd BLAST73
PeptideiPRO_0000008243100 – 104Met-enkephalin5
PeptideiPRO_0000008244107 – 111Met-enkephalin5
PeptideiPRO_0000377691114 – 133PENK(114-133)By similarityAdd BLAST20
PeptideiPRO_0000008246136 – 140Met-enkephalin5
PeptideiPRO_0000377692143 – 183PENK(143-183)By similarityAdd BLAST41
PeptideiPRO_0000008248186 – 193Met-enkephalin-Arg-Gly-Leu8
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000008249196 – 207Add BLAST12
PeptideiPRO_0000008250210 – 214Met-enkephalin5
PropeptideiPRO_0000008251217 – 227Add BLAST11
PeptideiPRO_0000008252230 – 234Leu-enkephalin5
PeptideiPRO_0000377693237 – 258PENK(237-258)By similarityAdd BLAST22
PeptideiPRO_0000008254261 – 267Met-enkephalin-Arg-Phe7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26 ↔ 481 Publication
Disulfide bondi30 ↔ 521 Publication
Disulfide bondi33 ↔ 651 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei111 – 112Cleavage; by CTSLBy similarity2
Sitei112 – 113Cleavage; by CTSLBy similarity2
Sitei133 – 134Cleavage; by CTSLBy similarity2
Sitei214 – 215Cleavage; by CTSLBy similarity2
Sitei215 – 216Cleavage; by CTSLBy similarity2
Sitei218 – 219Cleavage; by CTSLBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P01210

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01210

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01210

PeptideAtlas

More...PeptideAtlasi		P01210

PRoteomics IDEntifications database

More...PRIDEi		P01210

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51344

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01210

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01210

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000181195, Expressed in caudate nucleus and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P01210, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01210, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000181195, Group enriched (adrenal gland, brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111205, 8 interactors

Protein interaction database and analysis system

More...IntActi		P01210, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000324248

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01210, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01210

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P01210

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni163 – 182DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the opioid neuropeptide precursor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWWK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183149

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070973_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01210

Identification of Orthologs from Complete Genome Data

More...OMAi		DELYPVE

Database of Orthologous Groups

More...OrthoDBi		1149395at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01210

TreeFam database of animal gene trees

More...TreeFami		TF332620

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006024, Opioid_neupept
IPR000703, Proenkphlin_A

The PANTHER Classification System

More...PANTHERi		PTHR11438, PTHR11438, 1 hit
PTHR11438:SF3, PTHR11438:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01160, Opiods_neuropep, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01028, OPIOIDPRCRSR
PR01029, PENKAPRCRSR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01252, OPIOIDS_PRECURSOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P01210-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADINFLACVM 
        60         70         80         90        100
ECEGKLPSLK IWETCKELLQ LSKPELPQDG TSTLRENSKP EESHLLAKRY 
       110        120        130        140        150
GGFMKRYGGF MKKMDELYPM EPEEEANGSE ILAKRYGGFM KKDAEEDDSL 
       160        170        180        190        200
ANSSDLLKEL LETGDNRERS HHQDGSDNEE EVSKRYGGFM RGLKRSPQLE 
       210        220        230        240        250
DEAKELQKRY GGFMRRVGRP EWWMDYQKRY GGFLKRFAEA LPSDEEGESY 
       260 
SKEVPEMEKR YGGFMRF
Length:267
Mass (Da):30,787
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4189BA600C3FC8EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFR1E5RFR1_HUMAN
Proenkephalin-A
PENK
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIP6E5RIP6_HUMAN
Proenkephalin-A
PENK
79Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ72E5RJ72_HUMAN
Proenkephalin-A
PENK
92Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBT5H0YBT5_HUMAN
Proenkephalin-A
PENK
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119P → S in CAG46627 (Ref. 4) Curated1
Sequence conflicti152N → I in CAG46607 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04893583T → N. Corresponds to variant dbSNP:rs11998459EnsemblClinVar.1
Natural variantiVAR_014584247G → D. Corresponds to variant dbSNP:rs1800567Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
V00509 Genomic DNA Translation: CAA23767.1
J00123, J00122 Genomic DNA Translation: AAB59409.1
AK314908 mRNA Translation: BAG37420.1
CR541808 mRNA Translation: CAG46607.1
CR541828 mRNA Translation: CAG46627.1
CH471068 Genomic DNA Translation: EAW86785.1
BC032505 mRNA Translation: AAH32505.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6168.1

Protein sequence database of the Protein Information Resource

More...PIRi		A93278, EQHUA

NCBI Reference Sequences

More...RefSeqi		NP_001129162.1, NM_001135690.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000314922; ENSP00000324248; ENSG00000181195
ENST00000451791; ENSP00000400894; ENSG00000181195

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5179

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000451791.7; ENSP00000400894.2; NM_001135690.3; NP_001129162.1

UCSC genome browser

More...UCSCi		uc003xsz.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00509 Genomic DNA Translation: CAA23767.1
J00123, J00122 Genomic DNA Translation: AAB59409.1
AK314908 mRNA Translation: BAG37420.1
CR541808 mRNA Translation: CAG46607.1
CR541828 mRNA Translation: CAG46627.1
CH471068 Genomic DNA Translation: EAW86785.1
BC032505 mRNA Translation: AAH32505.1
CCDSiCCDS6168.1
PIRiA93278, EQHUA
RefSeqiNP_001129162.1, NM_001135690.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PLWNMR-A100-104[»]
1PLXNMR-A100-104[»]
2LWCNMR-A261-265[»]
5E33X-ray1.84B261-265[»]
5E3AX-ray2.05B230-234[»]
SMRiP01210
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111205, 8 interactors
IntActiP01210, 9 interactors
STRINGi9606.ENSP00000324248

Protein family/group databases

TCDBi1.C.89.1.2, the dynorphin channel-forming neuropeptide (dynorphin) family

PTM databases

iPTMnetiP01210
PhosphoSitePlusiP01210

Genetic variation databases

BioMutaiPENK
DMDMi129770

Proteomic databases

jPOSTiP01210
MassIVEiP01210
PaxDbiP01210
PeptideAtlasiP01210
PRIDEiP01210
ProteomicsDBi51344

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2211, 394 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		5179

Genome annotation databases

EnsembliENST00000314922; ENSP00000324248; ENSG00000181195
ENST00000451791; ENSP00000400894; ENSG00000181195
GeneIDi5179
KEGGihsa:5179
MANE-SelectiENST00000451791.7; ENSP00000400894.2; NM_001135690.3; NP_001129162.1
UCSCiuc003xsz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5179
DisGeNETi5179

GeneCards: human genes, protein and diseases

More...GeneCardsi		PENK
HGNCiHGNC:8831, PENK
HPAiENSG00000181195, Group enriched (adrenal gland, brain, testis)
MIMi131330, gene
neXtProtiNX_P01210
OpenTargetsiENSG00000181195
PharmGKBiPA33176
VEuPathDBiHostDB:ENSG00000181195

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWWK, Eukaryota
GeneTreeiENSGT00950000183149
HOGENOMiCLU_070973_0_0_1
InParanoidiP01210
OMAiDELYPVE
OrthoDBi1149395at2759
PhylomeDBiP01210
TreeFamiTF332620

Enzyme and pathway databases

PathwayCommonsiP01210
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-418594, G alpha (i) signalling events
R-HSA-8957275, Post-translational protein phosphorylation
SignaLinkiP01210
SIGNORiP01210

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5179, 1 hit in 1032 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PENK, human
EvolutionaryTraceiP01210

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5179
PharosiP01210, Tbio

Protein Ontology

More...PROi		PR:P01210
RNActiP01210, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000181195, Expressed in caudate nucleus and 205 other tissues
ExpressionAtlasiP01210, baseline and differential
GenevisibleiP01210, HS

Family and domain databases

InterProiView protein in InterPro
IPR006024, Opioid_neupept
IPR000703, Proenkphlin_A
PANTHERiPTHR11438, PTHR11438, 1 hit
PTHR11438:SF3, PTHR11438:SF3, 1 hit
PfamiView protein in Pfam
PF01160, Opiods_neuropep, 1 hit
PRINTSiPR01028, OPIOIDPRCRSR
PR01029, PENKAPRCRSR
PROSITEiView protein in PROSITE
PS01252, OPIOIDS_PRECURSOR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPENK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01210
Secondary accession number(s): B2RC23, Q6FHC6, Q6FHE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 23, 2022
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again