UniProtKB - P01194 (COLI_RAT)
Protein
Pro-opiomelanocortin
Gene
Pomc
Organism
Rattus norvegicus (Rat)
Status
Functioni
Stimulates the adrenal glands to release cortisol.
Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Increases the pigmentation of skin by increasing melanin production in melanocytes.
Endogenous orexigenic opiate.
Endogenous opiate.
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
- hormone activity Source: RGD
- signaling receptor binding Source: RGD
- type 1 melanocortin receptor binding Source: RGD
- type 3 melanocortin receptor binding Source: RGD
- type 4 melanocortin receptor binding Source: RGD
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: RGD
- cell-cell signaling Source: RGD
- cellular pigmentation Source: RGD
- feeding behavior Source: RGD
- generation of precursor metabolites and energy Source: RGD
- glucose homeostasis Source: RGD
- killing of cells of other organism Source: RGD
- modulation of process of other organism Source: RGD
- negative regulation of tumor necrosis factor production Source: RGD
- neuropeptide signaling pathway Source: UniProtKB-KW
- positive regulation of neutrophil mediated killing of fungus Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of appetite Source: RGD
- regulation of blood pressure Source: RGD
- regulation of corticosterone secretion Source: RGD
- regulation of glycogen metabolic process Source: RGD
- signal transduction Source: RGD
Keywordsi
Molecular function | Endorphin, Hormone |
Enzyme and pathway databases
Reactomei | R-RNO-111885, Opioid Signalling R-RNO-193048, Androgen biosynthesis R-RNO-194002, Glucocorticoid biosynthesis R-RNO-202040, G-protein activation R-RNO-209952, Peptide hormone biosynthesis R-RNO-211976, Endogenous sterols R-RNO-375276, Peptide ligand-binding receptors R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-opiomelanocortinShort name: POMC Alternative name(s): Corticotropin-lipotropin Cleaved into the following 11 chains: Alternative name(s): Gamma-MSH Alternative name(s): Adrenocorticotropic hormone Short name: ACTH Alternative name(s): Melanotropin alpha Alternative name(s): Beta-LPH Alternative name(s): Gamma-LPH Alternative name(s): Melanotropin beta |
Gene namesi | Name:Pomc Synonyms:Pomc2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3366, Pomc |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Note: Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.By similarity
Extracellular region or secreted
- extracellular region Source: RGD
- extracellular space Source: RGD
Peroxisome
- peroxisomal matrix Source: RGD
Other locations
- cytoplasm Source: RGD
- secretory granule Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | By similarityAdd BLAST | 26 | |
PeptideiPRO_0000025029 | 27 – 100 | NPPAdd BLAST | 74 | |
PeptideiPRO_0000025030 | 77 – 87 | Melanotropin gammaAdd BLAST | 11 | |
PeptideiPRO_0000437245 | 101 – 123 | Potential peptideAdd BLAST | 23 | |
PeptideiPRO_0000025031 | 124 – 162 | CorticotropinAdd BLAST | 39 | |
PeptideiPRO_0000025032 | 124 – 136 | Melanocyte-stimulating hormone alphaAdd BLAST | 13 | |
PeptideiPRO_0000025033 | 142 – 162 | Corticotropin-like intermediary peptideAdd BLAST | 21 | |
PeptideiPRO_0000025034 | 165 – 235 | Lipotropin betaAdd BLAST | 71 | |
PeptideiPRO_0000025035 | 165 – 202 | Lipotropin gammaAdd BLAST | 38 | |
PeptideiPRO_0000025036 | 185 – 202 | Melanocyte-stimulating hormone betaAdd BLAST | 18 | |
PeptideiPRO_0000025037 | 205 – 235 | Beta-endorphinAdd BLAST | 31 | |
PeptideiPRO_0000025038 | 205 – 209 | Met-enkephalin | 5 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 87 | Phenylalanine amideBy similarity | 1 | |
Modified residuei | 124 | N-acetylserine; in CorticotropinBy similarity | 1 | |
Modified residuei | 136 | Valine amideBy similarity | 1 | |
Glycosylationi | 152 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Modified residuei | 154 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Keywords - PTMi
Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P01194 |
PTM databases
GlyGeni | P01194, 1 site |
Expressioni
Tissue specificityi
ACTH and MSH are produced by the pituitary gland.
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
- hormone activity Source: RGD
- signaling receptor binding Source: RGD
- type 1 melanocortin receptor binding Source: RGD
- type 3 melanocortin receptor binding Source: RGD
- type 4 melanocortin receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016976 |
Family & Domainsi
Sequence similaritiesi
Belongs to the POMC family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RZNY, Eukaryota |
InParanoidi | P01194 |
PhylomeDBi | P01194 |
Family and domain databases
InterProi | View protein in InterPro IPR013531, Mcrtin_ACTH_cent IPR013593, Melanocortin_N IPR013532, Opioid_neuropept IPR001941, PMOC |
Pfami | View protein in Pfam PF00976, ACTH_domain, 3 hits PF08384, NPP, 1 hit PF08035, Op_neuropeptide, 1 hit |
PRINTSi | PR00383, MELANOCORTIN |
SMARTi | View protein in SMART SM01363, ACTH_domain, 2 hits SM01364, NPP, 1 hit SM01365, Op_neuropeptide, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P01194-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRFCNSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC
60 70 80 90 100
RLDLSAETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGGSAQ
110 120 130 140 150
RRAEEETAGG DGRPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA
160 170 180 190 200
ENESAEAFPL EFKRELEGEQ PDGLEQVLEP DTEKADGPYR VEHFRWGNPP
210 220 230
KDKRYGGFMT SEKSQTPLVT LFKNAIIKNV HKKGQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8K422 | Q8K422_RAT | Adrenocorticotropic hormone | Pomc rCG_62237 | 235 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | N → Y in CAA26937 (PubMed:2998878).Curated | 1 | |
Sequence conflicti | 6 | N → Y in AAA41903 (PubMed:2998878).Curated | 1 | |
Sequence conflicti | 40 | E → Y (PubMed:6547437).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03176 Genomic DNA Translation: CAA26937.1 K01877 Genomic DNA No translation available. J00759, K01878 Genomic DNA Translation: AAA41903.1 |
PIRi | A91353, CTRTP |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03176 Genomic DNA Translation: CAA26937.1 K01877 Genomic DNA No translation available. J00759, K01878 Genomic DNA Translation: AAA41903.1 |
PIRi | A91353, CTRTP |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016976 |
PTM databases
GlyGeni | P01194, 1 site |
Proteomic databases
PaxDbi | P01194 |
Organism-specific databases
RGDi | 3366, Pomc |
Phylogenomic databases
eggNOGi | ENOG502RZNY, Eukaryota |
InParanoidi | P01194 |
PhylomeDBi | P01194 |
Enzyme and pathway databases
Reactomei | R-RNO-111885, Opioid Signalling R-RNO-193048, Androgen biosynthesis R-RNO-194002, Glucocorticoid biosynthesis R-RNO-202040, G-protein activation R-RNO-209952, Peptide hormone biosynthesis R-RNO-211976, Endogenous sterols R-RNO-375276, Peptide ligand-binding receptors R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:P01194 |
Family and domain databases
InterProi | View protein in InterPro IPR013531, Mcrtin_ACTH_cent IPR013593, Melanocortin_N IPR013532, Opioid_neuropept IPR001941, PMOC |
Pfami | View protein in Pfam PF00976, ACTH_domain, 3 hits PF08384, NPP, 1 hit PF08035, Op_neuropeptide, 1 hit |
PRINTSi | PR00383, MELANOCORTIN |
SMARTi | View protein in SMART SM01363, ACTH_domain, 2 hits SM01364, NPP, 1 hit SM01365, Op_neuropeptide, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COLI_RAT | |
Accessioni | P01194Primary (citable) accession number: P01194 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 1, 1988 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families