Pomc

Functionⁱ

Corticotropin: Stimulates the adrenal glands to release cortisol.

Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.

Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.

Beta-endorphin: Endogenous orexigenic opiate.

Met-enkephalin: Endogenous opiate.

GO - Molecular functionⁱ

G protein-coupled receptor binding Source: UniProtKB
hormone activity
Source: MGI
Inferred from direct assayⁱ
- 15467755
signaling receptor binding Source: MGI
type 1 melanocortin receptor binding Source: UniProtKB
type 3 melanocortin receptor binding Source: MGI
type 4 melanocortin receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell signaling Source: UniProtKB
cellular pigmentation Source: UniProtKB
generation of precursor metabolites and energy Source: UniProtKB
glucose homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 21184805
negative regulation of tumor necrosis factor production Source: UniProtKB
neuropeptide signaling pathway Source: UniProtKB-KW
positive regulation of transcription by RNA polymerase II Source: UniProtKB
regulation of appetite Source: UniProtKB
regulation of blood pressure
Source: MGI
Inferred from genetic interactionⁱ
- 16243970
regulation of corticosterone secretion
Source: MGI
Inferred from mutant phenotypeⁱ
- 21184805
regulation of glycogen metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 21184805
signal transduction Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Endorphin, Hormone

Molecular function

Endorphin, Hormone

Enzyme and pathway databases

Reactomeⁱ	R-MMU-111885 Opioid Signalling R-MMU-193048 Androgen biosynthesis R-MMU-194002 Glucocorticoid biosynthesis R-MMU-202040 G-protein activation R-MMU-209952 Peptide hormone biosynthesis R-MMU-211976 Endogenous sterols R-MMU-375276 Peptide ligand-binding receptors R-MMU-418555 G alpha (s) signalling events R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-111885 Opioid Signalling
R-MMU-193048 Androgen biosynthesis
R-MMU-194002 Glucocorticoid biosynthesis
R-MMU-202040 G-protein activation
R-MMU-209952 Peptide hormone biosynthesis
R-MMU-211976 Endogenous sterols
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pro-opiomelanocortin Short name: POMC Alternative name(s): Corticotropin-lipotropin Cleaved into the following 10 chains: NPP Melanotropin gamma Alternative name(s): Gamma-MSH Corticotropin Alternative name(s): Adrenocorticotropic hormone Short name: ACTH Melanocyte-stimulating hormone alpha Short name: Alpha-MSH Alternative name(s): Melanotropin alpha Corticotropin-like intermediary peptide Short name: CLIP Lipotropin beta Alternative name(s): Beta-LPH Lipotropin gamma Alternative name(s): Gamma-LPH Melanocyte-stimulating hormone beta Short name: Beta-MSH Alternative name(s): Melanotropin beta Beta-endorphin Met-enkephalin
Gene namesⁱ	Name:Pomc Synonyms:Pomc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:97742 Pomc

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 26	By similarityAdd BLAST	26
PeptideⁱPRO_0000024996	27 – 100	NPPAdd BLAST	74
PeptideⁱPRO_0000024997	77 – 87	Melanotropin gammaAdd BLAST	11
PropeptideⁱPRO_0000024998	103 – 121	Add BLAST	19
PeptideⁱPRO_0000024999	124 – 162	CorticotropinAdd BLAST	39
PeptideⁱPRO_0000025000	124 – 136	Melanocyte-stimulating hormone alphaAdd BLAST	13
PeptideⁱPRO_0000025001	142 – 162	Corticotropin-like intermediary peptideAdd BLAST	21
PeptideⁱPRO_0000025002	165 – 235	Lipotropin betaAdd BLAST	71
PeptideⁱPRO_0000025003	165 – 202	Lipotropin gammaAdd BLAST	38
PeptideⁱPRO_0000025004	185 – 202	Melanocyte-stimulating hormone betaAdd BLAST	18
PeptideⁱPRO_0000025005	205 – 235	Beta-endorphinAdd BLAST	31
PeptideⁱPRO_0000025006	205 – 209	Met-enkephalin	5

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	87	Phenylalanine amideBy similarity	1
Glycosylationⁱ	91	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	124	N-acetylserine; in CorticotropinBy similarity	1
Modified residueⁱ	136	Valine amideBy similarity	1
Glycosylationⁱ	152	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	154	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMⁱ

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P01193
PeptideAtlas More...PeptideAtlasⁱ	P01193
PRIDEⁱ	P01193

PTM databases

GlyConnectⁱ	112
PhosphoSitePlusⁱ	P01193
UniCarbKBⁱ	P01193

Miscellaneous databases

PMAP-CutDBⁱ	P01193

PMAP-CutDBⁱ

P01193

Expressionⁱ

Tissue specificityⁱ

ACTH and MSH are produced by the pituitary gland.

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020660 Expressed in 132 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_POMC
ExpressionAtlasⁱ	P01193 baseline and differential
Genevisibleⁱ	P01193 MM

Interactionⁱ

GO - Molecular functionⁱ

G protein-coupled receptor binding Source: UniProtKB
hormone activity
Source: MGI
Inferred from direct assayⁱ
- 15467755
signaling receptor binding Source: MGI
type 1 melanocortin receptor binding Source: UniProtKB
type 3 melanocortin receptor binding Source: MGI
type 4 melanocortin receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ELMⁱ	P01193
STRINGⁱ	10090.ENSMUSP00000020990

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01193
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the POMC family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IKR5 Eukaryota ENOG410Z5R4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016811
HOGENOMⁱ	HOG000111887
HOVERGENⁱ	HBG004341
InParanoidⁱ	P01193
KEGG Orthology (KO) More...KOⁱ	K05228
OMAⁱ	VMSHFRW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0V3J
PhylomeDBⁱ	P01193
TreeFamⁱ	TF333215

Family and domain databases

InterProⁱ	View protein in InterPro IPR013531 Mcrtin_ACTH_cent IPR013593 Melanocortin_N IPR013532 Opioid_neuropept IPR001941 PMOC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00976 ACTH_domain, 3 hits PF08384 NPP, 1 hit PF08035 Op_neuropeptide, 1 hit
PRINTSⁱ	PR00383 MELANOCORTIN
SMARTⁱ	View protein in SMART SM01363 ACTH_domain, 2 hits SM01364 NPP, 1 hit SM01365 Op_neuropeptide, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P01193-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC 
        60         70         80         90        100
KLDLSLETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ 
       110        120        130        140        150
RRAEEEAVWG DGSPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA 
       160        170        180        190        200
ENESAEAFPL EFKRELEGER PLGLEQVLES DAEKDDGPYR VEHFRWSNPP 
       210        220        230 
KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ

Length:235

Mass (Da):26,707

Last modified:July 21, 1986 - v1

Checksum:ⁱEF98C0A95D6B4991

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1W2P7R2	A0A1W2P7R2_MOUSE	Pro-opiomelanocortin Pro-opiomelanocortin (Pro-opiomelanocortin-alpha, isoform CRA_b)	Pomc Pomc1, mCG_7946	79	Annotation score:
A0A1W2P724	A0A1W2P724_MOUSE	Pro-opiomelanocortin Pro-opiomelanocortin	Pomc	44	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	176	Q → H in CAA24770 (PubMed:6308009).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00612, J00611 Genomic DNA Translation: AAB59729.1 V01528 Genomic DNA Translation: CAA24769.1 V01529 Genomic DNA Translation: CAA24770.1 AK017492 mRNA Translation: BAB30771.1 AK017581 mRNA Translation: BAB30818.1 AK030714 mRNA Translation: BAC27095.1 AK077426 mRNA Translation: BAC36795.1 AK133592 mRNA Translation: BAE21739.1 AK133646 mRNA Translation: BAE21764.1 AK133740 mRNA Translation: BAE21815.1 AK133776 mRNA Translation: BAE21833.1 AK133800 mRNA Translation: BAE21850.1 BC061215 mRNA Translation: AAH61215.1 M30489 mRNA Translation: AAA37169.1 V00831 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25785.1
PIRⁱ	A91312 CTMSP
NCBI Reference Sequences More...RefSeqⁱ	NP_001265510.1, NM_001278581.1 NP_001265511.1, NM_001278582.1 NP_001265512.1, NM_001278583.1 NP_001265513.1, NM_001278584.1 NP_032921.1, NM_008895.4
UniGeneⁱ	Mm.277996

Genome annotation databases

Ensemblⁱ	ENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660 ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660 ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660
GeneIDⁱ	18976
KEGGⁱ	mmu:18976
UCSC genome browser More...UCSCⁱ	uc007mxe.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01193	Pro-opiomelanocortin (Fragment)		MOUSE		79	UniRef100_P01193
Pro-opiomelanocortin (Fragment)		MOUSE		44

Protein	Similar proteins		Species	Score	Length	Source
P01193	Pro-opiomelanocortin (Fragment)		MOUSE		79	UniRef90_P01193
UPI000A3199B8		MUSCR		235
Pro-opiomelanocortin (Fragment)		MOUSE		44

Protein	Similar proteins		Species	Score	Length	Source
P01193	Pro-opiomelanocortin		RAT		235	UniRef50_P01193
Pro-opiomelanocortin (Fragment)		RABIT		39
Pro-opiomelanocortin (Fragment)		MOUSE		79
Proopiomelanocortin (Fragment)		Phrynomantis microps		200
Proopiomelanocortin		COLLI		220
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00612, J00611 Genomic DNA Translation: AAB59729.1 V01528 Genomic DNA Translation: CAA24769.1 V01529 Genomic DNA Translation: CAA24770.1 AK017492 mRNA Translation: BAB30771.1 AK017581 mRNA Translation: BAB30818.1 AK030714 mRNA Translation: BAC27095.1 AK077426 mRNA Translation: BAC36795.1 AK133592 mRNA Translation: BAE21739.1 AK133646 mRNA Translation: BAE21764.1 AK133740 mRNA Translation: BAE21815.1 AK133776 mRNA Translation: BAE21833.1 AK133800 mRNA Translation: BAE21850.1 BC061215 mRNA Translation: AAH61215.1 M30489 mRNA Translation: AAA37169.1 V00831 mRNA No translation available.
CCDSⁱ	CCDS25785.1
PIRⁱ	A91312 CTMSP
RefSeqⁱ	NP_001265510.1, NM_001278581.1 NP_001265511.1, NM_001278582.1 NP_001265512.1, NM_001278583.1 NP_001265513.1, NM_001278584.1 NP_032921.1, NM_008895.4
UniGeneⁱ	Mm.277996

3D structure databases

ProteinModelPortalⁱ	P01193
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ELMⁱ	P01193
STRINGⁱ	10090.ENSMUSP00000020990

PTM databases

GlyConnectⁱ	112
PhosphoSitePlusⁱ	P01193
UniCarbKBⁱ	P01193

Proteomic databases

PaxDbⁱ	P01193
PeptideAtlasⁱ	P01193
PRIDEⁱ	P01193

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660 ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660 ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660
GeneIDⁱ	18976
KEGGⁱ	mmu:18976
UCSCⁱ	uc007mxe.2 mouse

Organism-specific databases

CTDⁱ	5443
MGIⁱ	MGI:97742 Pomc

Phylogenomic databases

eggNOGⁱ	ENOG410IKR5 Eukaryota ENOG410Z5R4 LUCA
GeneTreeⁱ	ENSGT00390000016811
HOGENOMⁱ	HOG000111887
HOVERGENⁱ	HBG004341
InParanoidⁱ	P01193
KOⁱ	K05228
OMAⁱ	VMSHFRW
OrthoDBⁱ	EOG091G0V3J
PhylomeDBⁱ	P01193
TreeFamⁱ	TF333215

Enzyme and pathway databases

Reactomeⁱ	R-MMU-111885 Opioid Signalling R-MMU-193048 Androgen biosynthesis R-MMU-194002 Glucocorticoid biosynthesis R-MMU-202040 G-protein activation R-MMU-209952 Peptide hormone biosynthesis R-MMU-211976 Endogenous sterols R-MMU-375276 Peptide ligand-binding receptors R-MMU-418555 G alpha (s) signalling events R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-111885 Opioid Signalling
R-MMU-193048 Androgen biosynthesis
R-MMU-194002 Glucocorticoid biosynthesis
R-MMU-202040 G-protein activation
R-MMU-209952 Peptide hormone biosynthesis
R-MMU-211976 Endogenous sterols
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSⁱ	Pomc mouse
PMAP-CutDBⁱ	P01193
Protein Ontology More...PROⁱ	PR:P01193
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020660 Expressed in 132 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_POMC
ExpressionAtlasⁱ	P01193 baseline and differential
Genevisibleⁱ	P01193 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR013531 Mcrtin_ACTH_cent IPR013593 Melanocortin_N IPR013532 Opioid_neuropept IPR001941 PMOC
Pfamⁱ	View protein in Pfam PF00976 ACTH_domain, 3 hits PF08384 NPP, 1 hit PF08035 Op_neuropeptide, 1 hit
PRINTSⁱ	PR00383 MELANOCORTIN
SMARTⁱ	View protein in SMART SM01363 ACTH_domain, 2 hits SM01364 NPP, 1 hit SM01365 Op_neuropeptide, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COLI_MOUSE
Accessionⁱ	P01193Primary (citable) accession number: P01193 Secondary accession number(s): P01200, Q544U4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01193 (COLI_MOUSE)

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Pro-opiomelanocortin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ