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UniProtKB - P01193 (COLI_MOUSE)

Entry version 175 (23 Feb 2022)
Sequence version 1 (21 Jul 1986)
Previous versions | rss
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Protein

Pro-opiomelanocortin

Gene

Pomc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates the adrenal glands to release cortisol.

Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.

Increases the pigmentation of skin by increasing melanin production in melanocytes.

Endogenous orexigenic opiate.

Endogenous opiate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndorphin, Hormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-111885, Opioid Signalling
R-MMU-193048, Androgen biosynthesis
R-MMU-194002, Glucocorticoid biosynthesis
R-MMU-202040, G-protein activation
R-MMU-209952, Peptide hormone biosynthesis
R-MMU-211976, Endogenous sterols
R-MMU-375276, Peptide ligand-binding receptors
R-MMU-418555, G alpha (s) signalling events
R-MMU-418594, G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 10 chains:
NPP
Melanotropin gamma
Alternative name(s):
Gamma-MSH
Corticotropin
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Melanocyte-stimulating hormone alpha
Short name:
Alpha-MSH
Alternative name(s):
Melanotropin alpha
Corticotropin-like intermediary peptide
Short name:
CLIP
Lipotropin beta
Alternative name(s):
Beta-LPH
Lipotropin gamma
Alternative name(s):
Gamma-LPH
Melanocyte-stimulating hormone beta
Short name:
Beta-MSH
Alternative name(s):
Melanotropin beta
Beta-endorphin
Met-enkephalin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pomc
Synonyms:Pomc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:97742, Pomc

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000020660

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26By similarityAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002499627 – 100NPPAdd BLAST74
PeptideiPRO_000002499777 – 87Melanotropin gammaAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000024998103 – 121Add BLAST19
PeptideiPRO_0000024999124 – 162CorticotropinAdd BLAST39
PeptideiPRO_0000025000124 – 136Melanocyte-stimulating hormone alphaAdd BLAST13
PeptideiPRO_0000025001142 – 162Corticotropin-like intermediary peptideAdd BLAST21
PeptideiPRO_0000025002165 – 235Lipotropin betaAdd BLAST71
PeptideiPRO_0000025003165 – 202Lipotropin gammaAdd BLAST38
PeptideiPRO_0000025004185 – 202Melanocyte-stimulating hormone betaAdd BLAST18
PeptideiPRO_0000025005205 – 235Beta-endorphinAdd BLAST31
PeptideiPRO_0000025006205 – 209Met-enkephalin5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87Phenylalanine amideBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei124N-acetylserine; in CorticotropinBy similarity1
Modified residuei136Valine amideBy similarity1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei154PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-4026

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01193

PeptideAtlas

More...PeptideAtlasi		P01193

PRoteomics IDEntifications database

More...PRIDEi		P01193

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		283426

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		112, 5 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P01193, 3 sites, 8 N-linked glycans (2 sites)

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01193

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In hypothalamic paraventricular nucleus (PVN), up-regulated by cannabinoids, including the CNR1/CB1R agonist arachidonyl-29-chloroethylamide (ACEA) (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000020660, Expressed in pituitary gland and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P01193, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01193, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		202295, 1 interactor

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P01193

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000020990

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01193, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P01193

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01193

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni88 – 126DisorderedSequence analysisAdd BLAST39
Regioni179 – 210DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi179 – 200Basic and acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RZNY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016811

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_094632_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01193

Identification of Orthologs from Complete Genome Data

More...OMAi		QVSMEVR

Database of Orthologous Groups

More...OrthoDBi		1168862at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01193

TreeFam database of animal gene trees

More...TreeFami		TF333215

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013531, Mcrtin_ACTH_cent
IPR013593, Melanocortin_N
IPR013532, Opioid_neuropept
IPR001941, PMOC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00976, ACTH_domain, 3 hits
PF08384, NPP, 1 hit
PF08035, Op_neuropeptide, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00383, MELANOCORTIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01363, ACTH_domain, 2 hits
SM01364, NPP, 1 hit
SM01365, Op_neuropeptide, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P01193-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC 
        60         70         80         90        100
KLDLSLETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ 
       110        120        130        140        150
RRAEEEAVWG DGSPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA 
       160        170        180        190        200
ENESAEAFPL EFKRELEGER PLGLEQVLES DAEKDDGPYR VEHFRWSNPP 
       210        220        230 
KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ
Length:235
Mass (Da):26,707
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF98C0A95D6B4991
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7R2A0A1W2P7R2_MOUSE
Pro-opiomelanocortin
Pomc
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P724A0A1W2P724_MOUSE
Pro-opiomelanocortin
Pomc
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176Q → H in CAA24770 (PubMed:6308009).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J00612, J00611 Genomic DNA Translation: AAB59729.1
V01528 Genomic DNA Translation: CAA24769.1
V01529 Genomic DNA Translation: CAA24770.1
AK017492 mRNA Translation: BAB30771.1
AK017581 mRNA Translation: BAB30818.1
AK030714 mRNA Translation: BAC27095.1
AK077426 mRNA Translation: BAC36795.1
AK133592 mRNA Translation: BAE21739.1
AK133646 mRNA Translation: BAE21764.1
AK133740 mRNA Translation: BAE21815.1
AK133776 mRNA Translation: BAE21833.1
AK133800 mRNA Translation: BAE21850.1
BC061215 mRNA Translation: AAH61215.1
M30489 mRNA Translation: AAA37169.1
V00831 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS25785.1

Protein sequence database of the Protein Information Resource

More...PIRi		A91312, CTMSP

NCBI Reference Sequences

More...RefSeqi		NP_001265510.1, NM_001278581.1
NP_001265511.1, NM_001278582.1
NP_001265512.1, NM_001278583.1
NP_001265513.1, NM_001278584.1
NP_032921.1, NM_008895.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660
ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660
ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18976

UCSC genome browser

More...UCSCi		uc007mxe.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00612, J00611 Genomic DNA Translation: AAB59729.1
V01528 Genomic DNA Translation: CAA24769.1
V01529 Genomic DNA Translation: CAA24770.1
AK017492 mRNA Translation: BAB30771.1
AK017581 mRNA Translation: BAB30818.1
AK030714 mRNA Translation: BAC27095.1
AK077426 mRNA Translation: BAC36795.1
AK133592 mRNA Translation: BAE21739.1
AK133646 mRNA Translation: BAE21764.1
AK133740 mRNA Translation: BAE21815.1
AK133776 mRNA Translation: BAE21833.1
AK133800 mRNA Translation: BAE21850.1
BC061215 mRNA Translation: AAH61215.1
M30489 mRNA Translation: AAA37169.1
V00831 mRNA No translation available.
CCDSiCCDS25785.1
PIRiA91312, CTMSP
RefSeqiNP_001265510.1, NM_001278581.1
NP_001265511.1, NM_001278582.1
NP_001265512.1, NM_001278583.1
NP_001265513.1, NM_001278584.1
NP_032921.1, NM_008895.4

3D structure databases

BMRBiP01193
SMRiP01193
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202295, 1 interactor
ELMiP01193
STRINGi10090.ENSMUSP00000020990

PTM databases

GlyConnecti112, 5 N-Linked glycans (1 site)
GlyGeniP01193, 3 sites, 8 N-linked glycans (2 sites)
PhosphoSitePlusiP01193

Proteomic databases

CPTACinon-CPTAC-4026
PaxDbiP01193
PeptideAtlasiP01193
PRIDEiP01193
ProteomicsDBi283426

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3452, 2395 antibodies from 43 providers

The DNASU plasmid repository

More...DNASUi		18976

Genome annotation databases

EnsembliENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660
ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660
ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660
GeneIDi18976
KEGGimmu:18976
UCSCiuc007mxe.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5443
MGIiMGI:97742, Pomc
VEuPathDBiHostDB:ENSMUSG00000020660

Phylogenomic databases

eggNOGiENOG502RZNY, Eukaryota
GeneTreeiENSGT00390000016811
HOGENOMiCLU_094632_0_0_1
InParanoidiP01193
OMAiQVSMEVR
OrthoDBi1168862at2759
PhylomeDBiP01193
TreeFamiTF333215

Enzyme and pathway databases

ReactomeiR-MMU-111885, Opioid Signalling
R-MMU-193048, Androgen biosynthesis
R-MMU-194002, Glucocorticoid biosynthesis
R-MMU-202040, G-protein activation
R-MMU-209952, Peptide hormone biosynthesis
R-MMU-211976, Endogenous sterols
R-MMU-375276, Peptide ligand-binding receptors
R-MMU-418555, G alpha (s) signalling events
R-MMU-418594, G alpha (i) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18976, 3 hits in 69 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pomc, mouse

Protein Ontology

More...PROi		PR:P01193
RNActiP01193, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000020660, Expressed in pituitary gland and 174 other tissues
ExpressionAtlasiP01193, baseline and differential
GenevisibleiP01193, MM

Family and domain databases

InterProiView protein in InterPro
IPR013531, Mcrtin_ACTH_cent
IPR013593, Melanocortin_N
IPR013532, Opioid_neuropept
IPR001941, PMOC
PfamiView protein in Pfam
PF00976, ACTH_domain, 3 hits
PF08384, NPP, 1 hit
PF08035, Op_neuropeptide, 1 hit
PRINTSiPR00383, MELANOCORTIN
SMARTiView protein in SMART
SM01363, ACTH_domain, 2 hits
SM01364, NPP, 1 hit
SM01365, Op_neuropeptide, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOLI_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01193
Secondary accession number(s): P01200, Q544U4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 23, 2022
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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