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UniProtKB - P01193 (COLI_MOUSE)
Protein
Pro-opiomelanocortin
Gene
Pomc
Organism
Mus musculus (Mouse)
Status
Functioni
Stimulates the adrenal glands to release cortisol.
Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Increases the pigmentation of skin by increasing melanin production in melanocytes.
Endogenous orexigenic opiate.
Endogenous opiate.
GO - Molecular functioni
- G protein-coupled receptor binding Source: UniProtKB
- hormone activity Source: MGI
- signaling receptor binding Source: MGI
- type 1 melanocortin receptor binding Source: UniProtKB
- type 3 melanocortin receptor binding Source: MGI
- type 4 melanocortin receptor binding Source: MGI
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
- calcium-mediated signaling Source: ARUK-UCL
- cell-cell signaling Source: UniProtKB
- cellular pigmentation Source: UniProtKB
- generation of precursor metabolites and energy Source: UniProtKB
- glucose homeostasis Source: MGI
- killing of cells of other organism Source: MGI
- modulation of process of other organism Source: MGI
- negative regulation of tumor necrosis factor production Source: UniProtKB
- neuropeptide signaling pathway Source: UniProtKB-KW
- positive regulation of cAMP-mediated signaling Source: ARUK-UCL
- positive regulation of neutrophil mediated killing of fungus Source: MGI
- positive regulation of oxytocin production Source: ARUK-UCL
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of appetite Source: UniProtKB
- regulation of blood pressure Source: MGI
- regulation of corticosterone secretion Source: MGI
- regulation of glycogen metabolic process Source: MGI
- response to melanocyte-stimulating hormone Source: ARUK-UCL
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | Endorphin, Hormone |
Enzyme and pathway databases
Reactomei | R-MMU-111885, Opioid Signalling R-MMU-193048, Androgen biosynthesis R-MMU-194002, Glucocorticoid biosynthesis R-MMU-202040, G-protein activation R-MMU-209952, Peptide hormone biosynthesis R-MMU-211976, Endogenous sterols R-MMU-375276, Peptide ligand-binding receptors R-MMU-418555, G alpha (s) signalling events R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-opiomelanocortinShort name: POMC Alternative name(s): Corticotropin-lipotropin Cleaved into the following 10 chains: Alternative name(s): Gamma-MSH Alternative name(s): Adrenocorticotropic hormone Short name: ACTH Alternative name(s): Melanotropin alpha Alternative name(s): Beta-LPH Alternative name(s): Gamma-LPH Alternative name(s): Melanotropin beta |
Gene namesi | Name:Pomc Synonyms:Pomc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97742, Pomc |
VEuPathDBi | HostDB:ENSMUSG00000020660 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Note: Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.1 Publication
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: MGI
Peroxisome
- peroxisomal matrix Source: MGI
Other locations
- cytoplasm Source: MGI
- secretory granule Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | By similarityAdd BLAST | 26 | |
PeptideiPRO_0000024996 | 27 – 100 | NPPAdd BLAST | 74 | |
PeptideiPRO_0000024997 | 77 – 87 | Melanotropin gammaAdd BLAST | 11 | |
PropeptideiPRO_0000024998 | 103 – 121 | Add BLAST | 19 | |
PeptideiPRO_0000024999 | 124 – 162 | CorticotropinAdd BLAST | 39 | |
PeptideiPRO_0000025000 | 124 – 136 | Melanocyte-stimulating hormone alphaAdd BLAST | 13 | |
PeptideiPRO_0000025001 | 142 – 162 | Corticotropin-like intermediary peptideAdd BLAST | 21 | |
PeptideiPRO_0000025002 | 165 – 235 | Lipotropin betaAdd BLAST | 71 | |
PeptideiPRO_0000025003 | 165 – 202 | Lipotropin gammaAdd BLAST | 38 | |
PeptideiPRO_0000025004 | 185 – 202 | Melanocyte-stimulating hormone betaAdd BLAST | 18 | |
PeptideiPRO_0000025005 | 205 – 235 | Beta-endorphinAdd BLAST | 31 | |
PeptideiPRO_0000025006 | 205 – 209 | Met-enkephalin | 5 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 87 | Phenylalanine amideBy similarity | 1 | |
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 124 | N-acetylserine; in CorticotropinBy similarity | 1 | |
Modified residuei | 136 | Valine amideBy similarity | 1 | |
Glycosylationi | 152 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 154 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Keywords - PTMi
Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-4026 |
PaxDbi | P01193 |
PeptideAtlasi | P01193 |
PRIDEi | P01193 |
ProteomicsDBi | 283426 |
PTM databases
GlyConnecti | 112, 5 N-Linked glycans (1 site) |
GlyGeni | P01193, 3 sites, 8 N-linked glycans (2 sites) |
PhosphoSitePlusi | P01193 |
Expressioni
Tissue specificityi
ACTH and MSH are produced by the pituitary gland.
Inductioni
In hypothalamic paraventricular nucleus (PVN), up-regulated by cannabinoids, including the CNR1/CB1R agonist arachidonyl-29-chloroethylamide (ACEA) (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000020660, Expressed in pituitary gland and 174 other tissues |
ExpressionAtlasi | P01193, baseline and differential |
Genevisiblei | P01193, MM |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: UniProtKB
- hormone activity Source: MGI
- signaling receptor binding Source: MGI
- type 1 melanocortin receptor binding Source: UniProtKB
- type 3 melanocortin receptor binding Source: MGI
- type 4 melanocortin receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202295, 1 interactor |
ELMi | P01193 |
STRINGi | 10090.ENSMUSP00000020990 |
Miscellaneous databases
RNActi | P01193, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 88 – 126 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 179 – 210 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 179 – 200 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the POMC family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RZNY, Eukaryota |
GeneTreei | ENSGT00390000016811 |
HOGENOMi | CLU_094632_0_0_1 |
InParanoidi | P01193 |
OMAi | QVSMEVR |
OrthoDBi | 1168862at2759 |
PhylomeDBi | P01193 |
TreeFami | TF333215 |
Family and domain databases
InterProi | View protein in InterPro IPR013531, Mcrtin_ACTH_cent IPR013593, Melanocortin_N IPR013532, Opioid_neuropept IPR001941, PMOC |
Pfami | View protein in Pfam PF00976, ACTH_domain, 3 hits PF08384, NPP, 1 hit PF08035, Op_neuropeptide, 1 hit |
PRINTSi | PR00383, MELANOCORTIN |
SMARTi | View protein in SMART SM01363, ACTH_domain, 2 hits SM01364, NPP, 1 hit SM01365, Op_neuropeptide, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P01193-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC
60 70 80 90 100
KLDLSLETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ
110 120 130 140 150
RRAEEEAVWG DGSPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA
160 170 180 190 200
ENESAEAFPL EFKRELEGER PLGLEQVLES DAEKDDGPYR VEHFRWSNPP
210 220 230
KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P7R2 | A0A1W2P7R2_MOUSE | Pro-opiomelanocortin | Pomc | 79 | Annotation score: | ||
A0A1W2P724 | A0A1W2P724_MOUSE | Pro-opiomelanocortin | Pomc | 44 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 176 | Q → H in CAA24770 (PubMed:6308009).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00612, J00611 Genomic DNA Translation: AAB59729.1 V01528 Genomic DNA Translation: CAA24769.1 V01529 Genomic DNA Translation: CAA24770.1 AK017492 mRNA Translation: BAB30771.1 AK017581 mRNA Translation: BAB30818.1 AK030714 mRNA Translation: BAC27095.1 AK077426 mRNA Translation: BAC36795.1 AK133592 mRNA Translation: BAE21739.1 AK133646 mRNA Translation: BAE21764.1 AK133740 mRNA Translation: BAE21815.1 AK133776 mRNA Translation: BAE21833.1 AK133800 mRNA Translation: BAE21850.1 BC061215 mRNA Translation: AAH61215.1 M30489 mRNA Translation: AAA37169.1 V00831 mRNA No translation available. |
CCDSi | CCDS25785.1 |
PIRi | A91312, CTMSP |
RefSeqi | NP_001265510.1, NM_001278581.1 NP_001265511.1, NM_001278582.1 NP_001265512.1, NM_001278583.1 NP_001265513.1, NM_001278584.1 NP_032921.1, NM_008895.4 |
Genome annotation databases
Ensembli | ENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660 ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660 ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660 |
GeneIDi | 18976 |
KEGGi | mmu:18976 |
UCSCi | uc007mxe.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00612, J00611 Genomic DNA Translation: AAB59729.1 V01528 Genomic DNA Translation: CAA24769.1 V01529 Genomic DNA Translation: CAA24770.1 AK017492 mRNA Translation: BAB30771.1 AK017581 mRNA Translation: BAB30818.1 AK030714 mRNA Translation: BAC27095.1 AK077426 mRNA Translation: BAC36795.1 AK133592 mRNA Translation: BAE21739.1 AK133646 mRNA Translation: BAE21764.1 AK133740 mRNA Translation: BAE21815.1 AK133776 mRNA Translation: BAE21833.1 AK133800 mRNA Translation: BAE21850.1 BC061215 mRNA Translation: AAH61215.1 M30489 mRNA Translation: AAA37169.1 V00831 mRNA No translation available. |
CCDSi | CCDS25785.1 |
PIRi | A91312, CTMSP |
RefSeqi | NP_001265510.1, NM_001278581.1 NP_001265511.1, NM_001278582.1 NP_001265512.1, NM_001278583.1 NP_001265513.1, NM_001278584.1 NP_032921.1, NM_008895.4 |
3D structure databases
BMRBi | P01193 |
SMRi | P01193 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202295, 1 interactor |
ELMi | P01193 |
STRINGi | 10090.ENSMUSP00000020990 |
PTM databases
GlyConnecti | 112, 5 N-Linked glycans (1 site) |
GlyGeni | P01193, 3 sites, 8 N-linked glycans (2 sites) |
PhosphoSitePlusi | P01193 |
Proteomic databases
CPTACi | non-CPTAC-4026 |
PaxDbi | P01193 |
PeptideAtlasi | P01193 |
PRIDEi | P01193 |
ProteomicsDBi | 283426 |
Protocols and materials databases
Antibodypediai | 3452, 2395 antibodies from 43 providers |
DNASUi | 18976 |
Genome annotation databases
Ensembli | ENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660 ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660 ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660 |
GeneIDi | 18976 |
KEGGi | mmu:18976 |
UCSCi | uc007mxe.2, mouse |
Organism-specific databases
CTDi | 5443 |
MGIi | MGI:97742, Pomc |
VEuPathDBi | HostDB:ENSMUSG00000020660 |
Phylogenomic databases
eggNOGi | ENOG502RZNY, Eukaryota |
GeneTreei | ENSGT00390000016811 |
HOGENOMi | CLU_094632_0_0_1 |
InParanoidi | P01193 |
OMAi | QVSMEVR |
OrthoDBi | 1168862at2759 |
PhylomeDBi | P01193 |
TreeFami | TF333215 |
Enzyme and pathway databases
Reactomei | R-MMU-111885, Opioid Signalling R-MMU-193048, Androgen biosynthesis R-MMU-194002, Glucocorticoid biosynthesis R-MMU-202040, G-protein activation R-MMU-209952, Peptide hormone biosynthesis R-MMU-211976, Endogenous sterols R-MMU-375276, Peptide ligand-binding receptors R-MMU-418555, G alpha (s) signalling events R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 18976, 3 hits in 69 CRISPR screens |
ChiTaRSi | Pomc, mouse |
PROi | PR:P01193 |
RNActi | P01193, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020660, Expressed in pituitary gland and 174 other tissues |
ExpressionAtlasi | P01193, baseline and differential |
Genevisiblei | P01193, MM |
Family and domain databases
InterProi | View protein in InterPro IPR013531, Mcrtin_ACTH_cent IPR013593, Melanocortin_N IPR013532, Opioid_neuropept IPR001941, PMOC |
Pfami | View protein in Pfam PF00976, ACTH_domain, 3 hits PF08384, NPP, 1 hit PF08035, Op_neuropeptide, 1 hit |
PRINTSi | PR00383, MELANOCORTIN |
SMARTi | View protein in SMART SM01363, ACTH_domain, 2 hits SM01364, NPP, 1 hit SM01365, Op_neuropeptide, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COLI_MOUSE | |
Accessioni | P01193Primary (citable) accession number: P01193 Secondary accession number(s): P01200, Q544U4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families