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Protein

Pro-opiomelanocortin

Gene

Pomc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Corticotropin: Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin: Endogenous orexigenic opiate.
Met-enkephalin: Endogenous opiate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndorphin, Hormone

Enzyme and pathway databases

ReactomeiR-MMU-111885 Opioid Signalling
R-MMU-193048 Androgen biosynthesis
R-MMU-194002 Glucocorticoid biosynthesis
R-MMU-202040 G-protein activation
R-MMU-209952 Peptide hormone biosynthesis
R-MMU-211976 Endogenous sterols
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 10 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Melanotropin alpha
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Melanotropin beta
Gene namesi
Name:Pomc
Synonyms:Pomc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:97742 Pomc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
PeptideiPRO_000002499627 – 100NPPAdd BLAST74
PeptideiPRO_000002499777 – 87Melanotropin gammaAdd BLAST11
PropeptideiPRO_0000024998103 – 121Add BLAST19
PeptideiPRO_0000024999124 – 162CorticotropinAdd BLAST39
PeptideiPRO_0000025000124 – 136Melanocyte-stimulating hormone alphaAdd BLAST13
PeptideiPRO_0000025001142 – 162Corticotropin-like intermediary peptideAdd BLAST21
PeptideiPRO_0000025002165 – 235Lipotropin betaAdd BLAST71
PeptideiPRO_0000025003165 – 202Lipotropin gammaAdd BLAST38
PeptideiPRO_0000025004185 – 202Melanocyte-stimulating hormone betaAdd BLAST18
PeptideiPRO_0000025005205 – 235Beta-endorphinAdd BLAST31
PeptideiPRO_0000025006205 – 209Met-enkephalin5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87Phenylalanine amideBy similarity1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei124N-acetylserine; in CorticotropinBy similarity1
Modified residuei136Valine amideBy similarity1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei154PhosphoserineBy similarity1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01193
PeptideAtlasiP01193
PRIDEiP01193

PTM databases

GlyConnecti112
PhosphoSitePlusiP01193
UniCarbKBiP01193

Miscellaneous databases

PMAP-CutDBiP01193

Expressioni

Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Inductioni

Beta-endorphin: In hypothalamic paraventricular nucleus (PVN), up-regulated by cannabinoids, including the CNR1/CB1R agonist arachidonyl-29-chloroethylamide (ACEA) (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000020660 Expressed in 132 organ(s), highest expression level in pituitary gland
CleanExiMM_POMC
ExpressionAtlasiP01193 baseline and differential
GenevisibleiP01193 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ELMiP01193
STRINGi10090.ENSMUSP00000020990

Structurei

3D structure databases

ProteinModelPortaliP01193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKR5 Eukaryota
ENOG410Z5R4 LUCA
GeneTreeiENSGT00390000016811
HOGENOMiHOG000111887
HOVERGENiHBG004341
InParanoidiP01193
KOiK05228
OMAiVMSHFRW
OrthoDBiEOG091G0V3J
PhylomeDBiP01193
TreeFamiTF333215

Family and domain databases

InterProiView protein in InterPro
IPR013531 Mcrtin_ACTH_cent
IPR013593 Melanocortin_N
IPR013532 Opioid_neuropept
IPR001941 PMOC
PfamiView protein in Pfam
PF00976 ACTH_domain, 3 hits
PF08384 NPP, 1 hit
PF08035 Op_neuropeptide, 1 hit
PRINTSiPR00383 MELANOCORTIN
SMARTiView protein in SMART
SM01363 ACTH_domain, 2 hits
SM01364 NPP, 1 hit
SM01365 Op_neuropeptide, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P01193-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC
60 70 80 90 100
KLDLSLETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ
110 120 130 140 150
RRAEEEAVWG DGSPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA
160 170 180 190 200
ENESAEAFPL EFKRELEGER PLGLEQVLES DAEKDDGPYR VEHFRWSNPP
210 220 230
KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ
Length:235
Mass (Da):26,707
Last modified:July 21, 1986 - v1
Checksum:iEF98C0A95D6B4991
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7R2A0A1W2P7R2_MOUSE
Pro-opiomelanocortin
Pomc Pomc1, mCG_7946
79Annotation score:
A0A1W2P724A0A1W2P724_MOUSE
Pro-opiomelanocortin
Pomc
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176Q → H in CAA24770 (PubMed:6308009).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00612, J00611 Genomic DNA Translation: AAB59729.1
V01528 Genomic DNA Translation: CAA24769.1
V01529 Genomic DNA Translation: CAA24770.1
AK017492 mRNA Translation: BAB30771.1
AK017581 mRNA Translation: BAB30818.1
AK030714 mRNA Translation: BAC27095.1
AK077426 mRNA Translation: BAC36795.1
AK133592 mRNA Translation: BAE21739.1
AK133646 mRNA Translation: BAE21764.1
AK133740 mRNA Translation: BAE21815.1
AK133776 mRNA Translation: BAE21833.1
AK133800 mRNA Translation: BAE21850.1
BC061215 mRNA Translation: AAH61215.1
M30489 mRNA Translation: AAA37169.1
V00831 mRNA No translation available.
CCDSiCCDS25785.1
PIRiA91312 CTMSP
RefSeqiNP_001265510.1, NM_001278581.1
NP_001265511.1, NM_001278582.1
NP_001265512.1, NM_001278583.1
NP_001265513.1, NM_001278584.1
NP_032921.1, NM_008895.4
UniGeneiMm.277996

Genome annotation databases

EnsembliENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660
ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660
ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660
GeneIDi18976
KEGGimmu:18976
UCSCiuc007mxe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00612, J00611 Genomic DNA Translation: AAB59729.1
V01528 Genomic DNA Translation: CAA24769.1
V01529 Genomic DNA Translation: CAA24770.1
AK017492 mRNA Translation: BAB30771.1
AK017581 mRNA Translation: BAB30818.1
AK030714 mRNA Translation: BAC27095.1
AK077426 mRNA Translation: BAC36795.1
AK133592 mRNA Translation: BAE21739.1
AK133646 mRNA Translation: BAE21764.1
AK133740 mRNA Translation: BAE21815.1
AK133776 mRNA Translation: BAE21833.1
AK133800 mRNA Translation: BAE21850.1
BC061215 mRNA Translation: AAH61215.1
M30489 mRNA Translation: AAA37169.1
V00831 mRNA No translation available.
CCDSiCCDS25785.1
PIRiA91312 CTMSP
RefSeqiNP_001265510.1, NM_001278581.1
NP_001265511.1, NM_001278582.1
NP_001265512.1, NM_001278583.1
NP_001265513.1, NM_001278584.1
NP_032921.1, NM_008895.4
UniGeneiMm.277996

3D structure databases

ProteinModelPortaliP01193
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP01193
STRINGi10090.ENSMUSP00000020990

PTM databases

GlyConnecti112
PhosphoSitePlusiP01193
UniCarbKBiP01193

Proteomic databases

PaxDbiP01193
PeptideAtlasiP01193
PRIDEiP01193

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660
ENSMUST00000218089; ENSMUSP00000151367; ENSMUSG00000020660
ENSMUST00000219543; ENSMUSP00000151504; ENSMUSG00000020660
GeneIDi18976
KEGGimmu:18976
UCSCiuc007mxe.2 mouse

Organism-specific databases

CTDi5443
MGIiMGI:97742 Pomc

Phylogenomic databases

eggNOGiENOG410IKR5 Eukaryota
ENOG410Z5R4 LUCA
GeneTreeiENSGT00390000016811
HOGENOMiHOG000111887
HOVERGENiHBG004341
InParanoidiP01193
KOiK05228
OMAiVMSHFRW
OrthoDBiEOG091G0V3J
PhylomeDBiP01193
TreeFamiTF333215

Enzyme and pathway databases

ReactomeiR-MMU-111885 Opioid Signalling
R-MMU-193048 Androgen biosynthesis
R-MMU-194002 Glucocorticoid biosynthesis
R-MMU-202040 G-protein activation
R-MMU-209952 Peptide hormone biosynthesis
R-MMU-211976 Endogenous sterols
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiPomc mouse
PMAP-CutDBiP01193
PROiPR:P01193
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020660 Expressed in 132 organ(s), highest expression level in pituitary gland
CleanExiMM_POMC
ExpressionAtlasiP01193 baseline and differential
GenevisibleiP01193 MM

Family and domain databases

InterProiView protein in InterPro
IPR013531 Mcrtin_ACTH_cent
IPR013593 Melanocortin_N
IPR013532 Opioid_neuropept
IPR001941 PMOC
PfamiView protein in Pfam
PF00976 ACTH_domain, 3 hits
PF08384 NPP, 1 hit
PF08035 Op_neuropeptide, 1 hit
PRINTSiPR00383 MELANOCORTIN
SMARTiView protein in SMART
SM01363 ACTH_domain, 2 hits
SM01364 NPP, 1 hit
SM01365 Op_neuropeptide, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOLI_MOUSE
AccessioniPrimary (citable) accession number: P01193
Secondary accession number(s): P01200, Q544U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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