We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - P01190 (COLI_BOVIN)
Protein
Pro-opiomelanocortin
Gene
POMC
Organism
Bos taurus (Bovine)
Status
Functioni
Stimulates the adrenal glands to release cortisol.
Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Endogenous orexigenic opiate.
Endogenous opiate.
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- hormone activity Source: UniProtKB-KW
- type 1 melanocortin receptor binding Source: Ensembl
- type 3 melanocortin receptor binding Source: Ensembl
- type 4 melanocortin receptor binding Source: Ensembl
GO - Biological processi
- calcium-mediated signaling Source: Ensembl
- cell-cell signaling Source: Ensembl
- cellular pigmentation Source: Ensembl
- generation of precursor metabolites and energy Source: Ensembl
- glucose homeostasis Source: Ensembl
- negative regulation of tumor necrosis factor production Source: Ensembl
- neuropeptide signaling pathway Source: UniProtKB-KW
- positive regulation of cAMP-mediated signaling Source: Ensembl
- positive regulation of oxytocin production Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of appetite Source: Ensembl
- regulation of blood pressure Source: Ensembl
- regulation of corticosterone secretion Source: GO_Central
- regulation of glycogen metabolic process Source: Ensembl
- response to melanocyte-stimulating hormone Source: Ensembl
Keywordsi
Molecular function | Endorphin, Hormone |
Enzyme and pathway databases
Reactomei | R-BTA-193048, Androgen biosynthesis R-BTA-194002, Glucocorticoid biosynthesis R-BTA-211976, Endogenous sterols R-BTA-375276, Peptide ligand-binding receptors R-BTA-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-opiomelanocortinShort name: POMC Alternative name(s): Corticotropin-lipotropin Cleaved into the following 10 chains: Alternative name(s): Gamma-MSH Alternative name(s): Adrenocorticotropic hormone Short name: ACTH Alternative name(s): Melanotropin alpha Alternative name(s): Beta-LPH Alternative name(s): Gamma-LPH Alternative name(s): Melanotropin beta |
Gene namesi | Name:POMC |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000007897 |
VGNCi | VGNC:33155, POMC |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Note: Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- secretory granule Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | By similarityAdd BLAST | 26 | |
PeptideiPRO_0000024943 | 27 – 103 | NPPAdd BLAST | 77 | |
PeptideiPRO_0000024944 | 77 – 87 | Melanotropin gammaAdd BLAST | 11 | |
PropeptideiPRO_0000024945 | 106 – 129 | Add BLAST | 24 | |
PeptideiPRO_0000024946 | 132 – 170 | CorticotropinAdd BLAST | 39 | |
PeptideiPRO_0000024947 | 132 – 144 | Melanocyte-stimulating hormone alphaAdd BLAST | 13 | |
PeptideiPRO_0000024948 | 150 – 170 | Corticotropin-like intermediary peptideAdd BLAST | 21 | |
PeptideiPRO_0000024949 | 173 – 265 | Lipotropin betaAdd BLAST | 93 | |
PeptideiPRO_0000024950 | 173 – 232 | Lipotropin gammaAdd BLAST | 60 | |
PeptideiPRO_0000024951 | 215 – 232 | Melanocyte-stimulating hormone betaAdd BLAST | 18 | |
PeptideiPRO_0000024952 | 235 – 265 | Beta-endorphinAdd BLAST | 31 | |
PeptideiPRO_0000024953 | 235 – 239 | Met-enkephalin | 5 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 50 | 1 Publication | ||
Disulfide bondi | 34 ↔ 46 | 1 Publication | ||
GlycosylationiCAR_000202 | 71 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Modified residuei | 87 | Phenylalanine amide1 Publication | 1 | |
GlycosylationiCAR_000034 | 91 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 132 | N-acetylserine; in CorticotropinBy similarity | 1 | |
Modified residuei | 144 | Valine amide1 Publication | 1 | |
Modified residuei | 162 | PhosphoserineBy similarity | 1 | |
Modified residuei | 173 | Pyrrolidone carboxylic acid (Glu); partial1 Publication | 1 | |
Modified residuei | 200 | Sulfotyrosine1 Publication | 1 |
Post-translational modificationi
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Keywords - PTMi
Acetylation, Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid, SulfationProteomic databases
PaxDbi | P01190 |
PTM databases
GlyConnecti | 113, 12 N-Linked glycans (1 site), 4 O-Linked glycans (1 site) |
Expressioni
Tissue specificityi
ACTH and MSH are produced by the pituitary gland.
Gene expression databases
Bgeei | ENSBTAG00000007897, Expressed in neurohypophysis and 95 other tissues |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- hormone activity Source: UniProtKB-KW
- type 1 melanocortin receptor binding Source: Ensembl
- type 3 melanocortin receptor binding Source: Ensembl
- type 4 melanocortin receptor binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000010386 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 89 – 138 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 209 – 240 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 106 – 138 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 209 – 230 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the POMC family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RZNY, Eukaryota |
GeneTreei | ENSGT00390000016811 |
HOGENOMi | CLU_094632_0_0_1 |
InParanoidi | P01190 |
OMAi | KMHHFRW |
OrthoDBi | 1168862at2759 |
TreeFami | TF333215 |
Family and domain databases
InterProi | View protein in InterPro IPR013531, Mcrtin_ACTH_cent IPR013593, Melanocortin_N IPR013532, Opioid_neuropept IPR001941, PMOC |
Pfami | View protein in Pfam PF00976, ACTH_domain, 3 hits PF08384, NPP, 1 hit PF08035, Op_neuropeptide, 1 hit |
PRINTSi | PR00383, MELANOCORTIN |
SMARTi | View protein in SMART SM01363, ACTH_domain, 3 hits SM01364, NPP, 1 hit SM01365, Op_neuropeptide, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01190-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRLCSSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLACIRAC
60 70 80 90 100
KPDLSAETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NGSSSSGVGG
110 120 130 140 150
AAQKREEEVA VGEGPGPRGD DAETGPREDK RSYSMEHFRW GKPVGKKRRP
160 170 180 190 200
VKVYPNGAED ESAQAFPLEF KRELTGERLE QARGPEAQAE SAAARAELEY
210 220 230 240 250
GLVAEAEAEA AEKKDSGPYK MEHFRWGSPP KDKRYGGFMT SEKSQTPLVT
260
LFKNAIIKNA HKKGQ
Sequence cautioni
The sequence AAA30414 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | G → A in AAA30354 (PubMed:6249166).Curated | 1 | |
Sequence conflicti | 139 | R → P in AAA30354 (PubMed:6249166).Curated | 1 | |
Sequence conflicti | 161 | Missing in AAA30718 (PubMed:216007).Curated | 1 | |
Sequence conflicti | 188 | Q → G AA sequence (Ref. 11) Curated | 1 | |
Sequence conflicti | 190 – 191 | ES → D in AAA30718 (PubMed:216007).Curated | 2 | |
Sequence conflicti | 196 | A → P in AAA30354 (PubMed:6249166).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00107 mRNA Translation: CAA23441.1 V00107 mRNA Translation: CAA23440.1 M25587 mRNA Translation: AAA30354.1 J00021, J00019 Genomic DNA Translation: AAB59262.1 BC122728 mRNA Translation: AAI22729.1 M23814 mRNA Translation: AAA30414.1 Different initiation. M10723 mRNA Translation: AAA30718.1 |
PIRi | A93206, CTBOP |
RefSeqi | NP_776576.1, NM_174151.1 XP_005212977.1, XM_005212920.2 |
Genome annotation databases
Ensembli | ENSBTAT00000010386; ENSBTAP00000010386; ENSBTAG00000007897 |
GeneIDi | 281416 |
KEGGi | bta:281416 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00107 mRNA Translation: CAA23441.1 V00107 mRNA Translation: CAA23440.1 M25587 mRNA Translation: AAA30354.1 J00021, J00019 Genomic DNA Translation: AAB59262.1 BC122728 mRNA Translation: AAI22729.1 M23814 mRNA Translation: AAA30414.1 Different initiation. M10723 mRNA Translation: AAA30718.1 |
PIRi | A93206, CTBOP |
RefSeqi | NP_776576.1, NM_174151.1 XP_005212977.1, XM_005212920.2 |
3D structure databases
AlphaFoldDBi | P01190 |
BMRBi | P01190 |
SMRi | P01190 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000010386 |
PTM databases
GlyConnecti | 113, 12 N-Linked glycans (1 site), 4 O-Linked glycans (1 site) |
Proteomic databases
PaxDbi | P01190 |
Genome annotation databases
Ensembli | ENSBTAT00000010386; ENSBTAP00000010386; ENSBTAG00000007897 |
GeneIDi | 281416 |
KEGGi | bta:281416 |
Organism-specific databases
CTDi | 5443 |
VEuPathDBi | HostDB:ENSBTAG00000007897 |
VGNCi | VGNC:33155, POMC |
Phylogenomic databases
eggNOGi | ENOG502RZNY, Eukaryota |
GeneTreei | ENSGT00390000016811 |
HOGENOMi | CLU_094632_0_0_1 |
InParanoidi | P01190 |
OMAi | KMHHFRW |
OrthoDBi | 1168862at2759 |
TreeFami | TF333215 |
Enzyme and pathway databases
Reactomei | R-BTA-193048, Androgen biosynthesis R-BTA-194002, Glucocorticoid biosynthesis R-BTA-211976, Endogenous sterols R-BTA-375276, Peptide ligand-binding receptors R-BTA-418594, G alpha (i) signalling events |
Gene expression databases
Bgeei | ENSBTAG00000007897, Expressed in neurohypophysis and 95 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR013531, Mcrtin_ACTH_cent IPR013593, Melanocortin_N IPR013532, Opioid_neuropept IPR001941, PMOC |
Pfami | View protein in Pfam PF00976, ACTH_domain, 3 hits PF08384, NPP, 1 hit PF08035, Op_neuropeptide, 1 hit |
PRINTSi | PR00383, MELANOCORTIN |
SMARTi | View protein in SMART SM01363, ACTH_domain, 3 hits SM01364, NPP, 1 hit SM01365, Op_neuropeptide, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COLI_BOVIN | |
Accessioni | P01190Primary (citable) accession number: P01190 Secondary accession number(s): Q05B64 Q28168 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families