Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - P01190 (COLI_BOVIN)

Entry version 159 (25 May 2022)
Sequence version 1 (21 Jul 1986)
Previous versions | rss
Add a publicationFeedback
Protein

Pro-opiomelanocortin

Gene

POMC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates the adrenal glands to release cortisol.

Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.

Endogenous orexigenic opiate.

Endogenous opiate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndorphin, Hormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-BTA-193048, Androgen biosynthesis
R-BTA-194002, Glucocorticoid biosynthesis
R-BTA-211976, Endogenous sterols
R-BTA-375276, Peptide ligand-binding receptors
R-BTA-418594, G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 10 chains:
NPP
Melanotropin gamma
Alternative name(s):
Gamma-MSH
Corticotropin
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Melanocyte-stimulating hormone alpha
Short name:
Alpha-MSH
Alternative name(s):
Melanotropin alpha
Corticotropin-like intermediary peptide
Short name:
CLIP
Lipotropin beta
Alternative name(s):
Beta-LPH
Lipotropin gamma
Alternative name(s):
Gamma-LPH
Melanocyte-stimulating hormone beta
Short name:
Beta-MSH
Alternative name(s):
Melanotropin beta
Beta-endorphin
Met-enkephalin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POMC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSBTAG00000007897

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:33155, POMC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26By similarityAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002494327 – 103NPPAdd BLAST77
PeptideiPRO_000002494477 – 87Melanotropin gammaAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000024945106 – 129Add BLAST24
PeptideiPRO_0000024946132 – 170CorticotropinAdd BLAST39
PeptideiPRO_0000024947132 – 144Melanocyte-stimulating hormone alphaAdd BLAST13
PeptideiPRO_0000024948150 – 170Corticotropin-like intermediary peptideAdd BLAST21
PeptideiPRO_0000024949173 – 265Lipotropin betaAdd BLAST93
PeptideiPRO_0000024950173 – 232Lipotropin gammaAdd BLAST60
PeptideiPRO_0000024951215 – 232Melanocyte-stimulating hormone betaAdd BLAST18
PeptideiPRO_0000024952235 – 265Beta-endorphinAdd BLAST31
PeptideiPRO_0000024953235 – 239Met-enkephalin5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 501 Publication
Disulfide bondi34 ↔ 461 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00020271O-linked (GalNAc...) threonine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87Phenylalanine amide1 Publication1
GlycosylationiCAR_00003491N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei132N-acetylserine; in CorticotropinBy similarity1
Modified residuei144Valine amide1 Publication1
Modified residuei162PhosphoserineBy similarity1
Modified residuei173Pyrrolidone carboxylic acid (Glu); partial1 Publication1
Modified residuei200Sulfotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01190

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		113, 12 N-Linked glycans (1 site), 4 O-Linked glycans (1 site)

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSBTAG00000007897, Expressed in neurohypophysis and 95 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9913.ENSBTAP00000010386

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P01190

Biological Magnetic Resonance Data Bank

More...BMRBi		P01190

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01190

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni89 – 138DisorderedSequence analysisAdd BLAST50
Regioni209 – 240DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 138Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi209 – 230Basic and acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RZNY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016811

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_094632_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01190

Identification of Orthologs from Complete Genome Data

More...OMAi		KMHHFRW

Database of Orthologous Groups

More...OrthoDBi		1168862at2759

TreeFam database of animal gene trees

More...TreeFami		TF333215

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013531, Mcrtin_ACTH_cent
IPR013593, Melanocortin_N
IPR013532, Opioid_neuropept
IPR001941, PMOC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00976, ACTH_domain, 3 hits
PF08384, NPP, 1 hit
PF08035, Op_neuropeptide, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00383, MELANOCORTIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01363, ACTH_domain, 3 hits
SM01364, NPP, 1 hit
SM01365, Op_neuropeptide, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01190-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRLCSSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLACIRAC 
        60         70         80         90        100
KPDLSAETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NGSSSSGVGG 
       110        120        130        140        150
AAQKREEEVA VGEGPGPRGD DAETGPREDK RSYSMEHFRW GKPVGKKRRP 
       160        170        180        190        200
VKVYPNGAED ESAQAFPLEF KRELTGERLE QARGPEAQAE SAAARAELEY 
       210        220        230        240        250
GLVAEAEAEA AEKKDSGPYK MEHFRWGSPP KDKRYGGFMT SEKSQTPLVT 
       260 
LFKNAIIKNA HKKGQ
Length:265
Mass (Da):29,260
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i303E9A0BCB073B3F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA30414 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10G → A in AAA30354 (PubMed:6249166).Curated1
Sequence conflicti139R → P in AAA30354 (PubMed:6249166).Curated1
Sequence conflicti161Missing in AAA30718 (PubMed:216007).Curated1
Sequence conflicti188Q → G AA sequence (Ref. 11) Curated1
Sequence conflicti190 – 191ES → D in AAA30718 (PubMed:216007).Curated2
Sequence conflicti196A → P in AAA30354 (PubMed:6249166).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
V00107 mRNA Translation: CAA23441.1
V00107 mRNA Translation: CAA23440.1
M25587 mRNA Translation: AAA30354.1
J00021, J00019 Genomic DNA Translation: AAB59262.1
BC122728 mRNA Translation: AAI22729.1
M23814 mRNA Translation: AAA30414.1 Different initiation.
M10723 mRNA Translation: AAA30718.1

Protein sequence database of the Protein Information Resource

More...PIRi		A93206, CTBOP

NCBI Reference Sequences

More...RefSeqi		NP_776576.1, NM_174151.1
XP_005212977.1, XM_005212920.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSBTAT00000010386; ENSBTAP00000010386; ENSBTAG00000007897

Database of genes from NCBI RefSeq genomes

More...GeneIDi		281416

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bta:281416

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00107 mRNA Translation: CAA23441.1
V00107 mRNA Translation: CAA23440.1
M25587 mRNA Translation: AAA30354.1
J00021, J00019 Genomic DNA Translation: AAB59262.1
BC122728 mRNA Translation: AAI22729.1
M23814 mRNA Translation: AAA30414.1 Different initiation.
M10723 mRNA Translation: AAA30718.1
PIRiA93206, CTBOP
RefSeqiNP_776576.1, NM_174151.1
XP_005212977.1, XM_005212920.2

3D structure databases

AlphaFoldDBiP01190
BMRBiP01190
SMRiP01190
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010386

PTM databases

GlyConnecti113, 12 N-Linked glycans (1 site), 4 O-Linked glycans (1 site)

Proteomic databases

PaxDbiP01190

Genome annotation databases

EnsembliENSBTAT00000010386; ENSBTAP00000010386; ENSBTAG00000007897
GeneIDi281416
KEGGibta:281416

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5443
VEuPathDBiHostDB:ENSBTAG00000007897
VGNCiVGNC:33155, POMC

Phylogenomic databases

eggNOGiENOG502RZNY, Eukaryota
GeneTreeiENSGT00390000016811
HOGENOMiCLU_094632_0_0_1
InParanoidiP01190
OMAiKMHHFRW
OrthoDBi1168862at2759
TreeFamiTF333215

Enzyme and pathway databases

ReactomeiR-BTA-193048, Androgen biosynthesis
R-BTA-194002, Glucocorticoid biosynthesis
R-BTA-211976, Endogenous sterols
R-BTA-375276, Peptide ligand-binding receptors
R-BTA-418594, G alpha (i) signalling events

Gene expression databases

BgeeiENSBTAG00000007897, Expressed in neurohypophysis and 95 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR013531, Mcrtin_ACTH_cent
IPR013593, Melanocortin_N
IPR013532, Opioid_neuropept
IPR001941, PMOC
PfamiView protein in Pfam
PF00976, ACTH_domain, 3 hits
PF08384, NPP, 1 hit
PF08035, Op_neuropeptide, 1 hit
PRINTSiPR00383, MELANOCORTIN
SMARTiView protein in SMART
SM01363, ACTH_domain, 3 hits
SM01364, NPP, 1 hit
SM01365, Op_neuropeptide, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOLI_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01190
Secondary accession number(s): Q05B64
, Q28166, Q28167, Q28168
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 25, 2022
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again