UniProtKB - P01185 (NEU2_HUMAN)
Protein
Vasopressin-neurophysin 2-copeptin
Gene
AVP
Organism
Homo sapiens (Human)
Status
Functioni
Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156).1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 28 | Important for agonist activity on V1aR/AVPR1A1 Publication | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
- neurohypophyseal hormone activity Source: InterPro
- neuropeptide hormone activity Source: UniProtKB
- protein kinase activity Source: UniProtKB
- signaling receptor binding Source: ProtInc
- V1A vasopressin receptor binding Source: UniProtKB
- V1B vasopressin receptor binding Source: Ensembl
GO - Biological processi
- cell-cell signaling Source: ProtInc
- ERK1 and ERK2 cascade Source: UniProtKB
- generation of precursor metabolites and energy Source: ProtInc
- G protein-coupled receptor signaling pathway Source: Reactome
- grooming behavior Source: Ensembl
- hyperosmotic salinity response Source: Ensembl
- locomotory behavior Source: Ensembl
- maternal aggressive behavior Source: Ensembl
- maternal behavior Source: Ensembl
- membrane organization Source: Reactome
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- negative regulation of female receptivity Source: Ensembl
- negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
- negative regulation of transmission of nerve impulse Source: Ensembl
- penile erection Source: Ensembl
- positive regulation of cell growth Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cellular pH reduction Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of gene expression Source: UniProtKB
- positive regulation of glutamate secretion Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of prostaglandin biosynthetic process Source: Ensembl
- positive regulation of systemic arterial blood pressure Source: Ensembl
- positive regulation of vasoconstriction Source: Ensembl
- protein kinase C signaling Source: UniProtKB
- regulation of renal sodium excretion Source: Ensembl
- renal water homeostasis Source: Reactome
- response to ethanol Source: Ensembl
- response to nicotine Source: Ensembl
- response to testosterone Source: Ensembl
- signal transduction Source: UniProtKB
- social behavior Source: Ensembl
- vasoconstriction Source: UniProtKB-KW
- water transport Source: ProtInc
Keywordsi
Molecular function | Hormone, Vasoactive, Vasoconstrictor |
Enzyme and pathway databases
PathwayCommonsi | P01185 |
Reactomei | R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-388479, Vasopressin-like receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418555, G alpha (s) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5619099, Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-879518, Transport of organic anions R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9036092, Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SIGNORi | P01185 |
Names & Taxonomyi
Protein namesi | Recommended name: Vasopressin-neurophysin 2-copeptinAlternative name(s): AVP-NPII Cleaved into the following 3 chains: Alternative name(s): Arginine-vasopressin Alternative name(s): Neurophysin-II |
Gene namesi | Name:AVP Synonyms:ARVP, VP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101200.5 |
HGNCi | HGNC:894, AVP |
MIMi | 192340, gene |
neXtProti | NX_P01185 |
Subcellular locationi
Extracellular region or secreted
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- clathrin-coated vesicle membrane Source: Reactome
- dendrite Source: Ensembl
- secretory granule Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Diabetes insipidus, neurohypophyseal (NDI)27 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004980 | 17 | S → F in NDI. 1 Publication | 1 | |
Natural variantiVAR_004981 | 19 | A → T in NDI; probably causes insufficient processing of precursor. 6 PublicationsCorresponds to variant dbSNP:rs387906511EnsemblClinVar. | 1 | |
Natural variantiVAR_004982 | 19 | A → V in NDI. 2 PublicationsCorresponds to variant dbSNP:rs387906512EnsemblClinVar. | 1 | |
Natural variantiVAR_015262 | 21 | Y → H in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964893EnsemblClinVar. | 1 | |
Natural variantiVAR_015263 | 26 | P → L in NDI; weakly active. 1 PublicationCorresponds to variant dbSNP:rs142886338Ensembl. | 1 | |
Natural variantiVAR_004983 | 45 | G → R in NDI. 1 Publication | 1 | |
Natural variantiVAR_004984 | 48 | G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964883EnsemblClinVar. | 1 | |
Natural variantiVAR_004985 | 51 | R → C in NDI. 1 Publication | 1 | |
Natural variantiVAR_015264 | 52 | C → R in NDI. | 1 | |
Natural variantiVAR_015265 | 54 | G → R in NDI. 3 PublicationsCorresponds to variant dbSNP:rs121964888EnsemblClinVar. | 1 | |
Natural variantiVAR_015266 | 54 | G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964887EnsemblClinVar. | 1 | |
Natural variantiVAR_004986 | 55 | P → L in NDI. 1 Publication | 1 | |
Natural variantiVAR_029997 | 58 | C → F in NDI. 1 Publication | 1 | |
Natural variantiVAR_015267 | 59 | C → R in NDI. | 1 | |
Natural variantiVAR_015268 | 59 | C → Y in NDI. 1 Publication | 1 | |
Natural variantiVAR_019273 | 67 | V → A in NDI. 1 PublicationCorresponds to variant dbSNP:rs28934878EnsemblClinVar. | 1 | |
Natural variantiVAR_004988 | 78 | E → G in NDI. 2 Publications | 1 | |
Natural variantiVAR_004987 | 78 | Missing in NDI. 2 Publications | 1 | |
Natural variantiVAR_004989 | 81 | L → P in NDI. 1 Publication | 1 | |
Natural variantiVAR_015269 | 87 | S → F in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964890EnsemblClinVar. | 1 | |
Natural variantiVAR_004990 | 88 | G → R in NDI. 1 Publication | 1 | |
Natural variantiVAR_004991 | 88 | G → S in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964882EnsemblClinVar. | 1 | |
Natural variantiVAR_004992 | 92 | C → S in NDI. 2 Publications | 1 | |
Natural variantiVAR_015270 | 92 | C → Y in NDI. 2 PublicationsCorresponds to variant dbSNP:rs121964891EnsemblClinVar. | 1 | |
Natural variantiVAR_004993 | 93 | G → W in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964885EnsemblClinVar. | 1 | |
Natural variantiVAR_004994 | 96 | G → C in NDI. 2 Publications | 1 | |
Natural variantiVAR_019274 | 96 | G → D in NDI. 1 Publication | 1 | |
Natural variantiVAR_015271 | 96 | G → V in NDI. Corresponds to variant dbSNP:rs121964886EnsemblClinVar. | 1 | |
Natural variantiVAR_015272 | 97 | R → C in NDI. | 1 | |
Natural variantiVAR_015273 | 97 | R → P in NDI. 1 Publication | 1 | |
Natural variantiVAR_015274 | 98 | C → G in NDI. 1 Publication | 1 | |
Natural variantiVAR_029998 | 98 | C → S in NDI. 1 Publication | 1 | |
Natural variantiVAR_029999 | 99 | A → P in NDI. 1 Publication | 1 | |
Natural variantiVAR_015275 | 104 | C → F in NDI. 1 Publication | 1 | |
Natural variantiVAR_019275 | 104 | C → G in NDI. 1 Publication | 1 | |
Natural variantiVAR_015276 | 105 | C → R in NDI. 1 Publication | 1 | |
Natural variantiVAR_015279 | 105 | C → Y in NDI. 1 Publication | 1 | |
Natural variantiVAR_015277 | 116 | C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 PublicationsCorresponds to variant dbSNP:rs74315383EnsemblClinVar. | 1 | |
Natural variantiVAR_015278 | 116 | C → R in NDI. 1 Publication | 1 | |
Natural variantiVAR_019276 | 116 | C → W in NDI. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 | G → V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 42-fold decrease in affinity for V1aR/AVPR1A, 2000-fold decrease in affinity for V1bR/AVPR1B, 5-fold decrease in affinity for V2R/AVPR2 and no change in affinity for oxytocin receptor (OXTR). 1 Publication | 1 |
Keywords - Diseasei
Diabetes insipidus, Disease mutationOrganism-specific databases
DisGeNETi | 551 |
MalaCardsi | AVP |
MIMi | 125700, phenotype |
OpenTargetsi | ENSG00000101200 |
Orphaneti | 30925, Hereditary central diabetes insipidus |
PharmGKBi | PA25186 |
Miscellaneous databases
Pharosi | P01185, Tbio |
Polymorphism and mutation databases
BioMutai | AVP |
DMDMi | 128083 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
PeptideiPRO_0000020515 | 20 – 28 | Arg-vasopressin1 Publication | 9 | |
ChainiPRO_0000020516 | 32 – 124 | Neurophysin 21 PublicationAdd BLAST | 93 | |
PeptideiPRO_0000020517 | 126 – 164 | Copeptin1 PublicationAdd BLAST | 39 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 20 ↔ 25 | |||
Modified residuei | 28 | Glycine amide1 Publication | 1 | |
Disulfide bondi | 41 ↔ 85 | By similarity | ||
Disulfide bondi | 44 ↔ 58 | By similarity | ||
Disulfide bondi | 52 ↔ 75 | By similarity | ||
Disulfide bondi | 59 ↔ 65 | By similarity | ||
Disulfide bondi | 92 ↔ 104 | By similarity | ||
Disulfide bondi | 98 ↔ 116 | By similarity | ||
Disulfide bondi | 105 ↔ 110 | By similarity | ||
Glycosylationi | 131 | N-linked (GlcNAc...) asparagine | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P01185 |
PaxDbi | P01185 |
PeptideAtlasi | P01185 |
PRIDEi | P01185 |
ProteomicsDBi | 51342 |
PTM databases
GlyGeni | P01185, 1 site |
iPTMneti | P01185 |
PhosphoSitePlusi | P01185 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101200, Expressed in hypothalamus and 87 other tissues |
ExpressionAtlasi | P01185, baseline and differential |
Genevisiblei | P01185, HS |
Organism-specific databases
HPAi | ENSG00000101200, Tissue enriched (brain) |
Interactioni
Subunit structurei
Binary interactionsi
P01185
With | #Exp. | IntAct |
---|---|---|
PRKAB2 [O43741] | 3 | EBI-6858021,EBI-1053424 |
GO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
- neuropeptide hormone activity Source: UniProtKB
- signaling receptor binding Source: ProtInc
- V1A vasopressin receptor binding Source: UniProtKB
- V1B vasopressin receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107032, 26 interactors |
IntActi | P01185, 21 interactors |
STRINGi | 9606.ENSP00000369647 |
Miscellaneous databases
RNActi | P01185, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the vasopressin/oxytocin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S21K, Eukaryota |
GeneTreei | ENSGT00390000004511 |
HOGENOMi | CLU_125770_0_0_1 |
InParanoidi | P01185 |
OMAi | CVTEPEC |
OrthoDBi | 1548839at2759 |
PhylomeDBi | P01185 |
TreeFami | TF333018 |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01185-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDTMLPACF LGLLAFSSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAA
110 120 130 140 150
FGVCCNDESC VTEPECREGF HRRARASDRS NATQLDGPAG ALLLRLVQLA
160
GAPEPFEPAQ PDAY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | L → P in AAA98772 (PubMed:2991279).Curated | 1 | |
Sequence conflicti | 48 | G → D in AAB86629 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004980 | 17 | S → F in NDI. 1 Publication | 1 | |
Natural variantiVAR_004981 | 19 | A → T in NDI; probably causes insufficient processing of precursor. 6 PublicationsCorresponds to variant dbSNP:rs387906511EnsemblClinVar. | 1 | |
Natural variantiVAR_004982 | 19 | A → V in NDI. 2 PublicationsCorresponds to variant dbSNP:rs387906512EnsemblClinVar. | 1 | |
Natural variantiVAR_015262 | 21 | Y → H in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964893EnsemblClinVar. | 1 | |
Natural variantiVAR_015263 | 26 | P → L in NDI; weakly active. 1 PublicationCorresponds to variant dbSNP:rs142886338Ensembl. | 1 | |
Natural variantiVAR_004983 | 45 | G → R in NDI. 1 Publication | 1 | |
Natural variantiVAR_004984 | 48 | G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964883EnsemblClinVar. | 1 | |
Natural variantiVAR_004985 | 51 | R → C in NDI. 1 Publication | 1 | |
Natural variantiVAR_015264 | 52 | C → R in NDI. | 1 | |
Natural variantiVAR_015265 | 54 | G → R in NDI. 3 PublicationsCorresponds to variant dbSNP:rs121964888EnsemblClinVar. | 1 | |
Natural variantiVAR_015266 | 54 | G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964887EnsemblClinVar. | 1 | |
Natural variantiVAR_004986 | 55 | P → L in NDI. 1 Publication | 1 | |
Natural variantiVAR_029997 | 58 | C → F in NDI. 1 Publication | 1 | |
Natural variantiVAR_015267 | 59 | C → R in NDI. | 1 | |
Natural variantiVAR_015268 | 59 | C → Y in NDI. 1 Publication | 1 | |
Natural variantiVAR_019273 | 67 | V → A in NDI. 1 PublicationCorresponds to variant dbSNP:rs28934878EnsemblClinVar. | 1 | |
Natural variantiVAR_004988 | 78 | E → G in NDI. 2 Publications | 1 | |
Natural variantiVAR_004987 | 78 | Missing in NDI. 2 Publications | 1 | |
Natural variantiVAR_004989 | 81 | L → P in NDI. 1 Publication | 1 | |
Natural variantiVAR_011894 | 82 | P → L. Corresponds to variant dbSNP:rs5195EnsemblClinVar. | 1 | |
Natural variantiVAR_015269 | 87 | S → F in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964890EnsemblClinVar. | 1 | |
Natural variantiVAR_004990 | 88 | G → R in NDI. 1 Publication | 1 | |
Natural variantiVAR_004991 | 88 | G → S in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964882EnsemblClinVar. | 1 | |
Natural variantiVAR_004992 | 92 | C → S in NDI. 2 Publications | 1 | |
Natural variantiVAR_015270 | 92 | C → Y in NDI. 2 PublicationsCorresponds to variant dbSNP:rs121964891EnsemblClinVar. | 1 | |
Natural variantiVAR_004993 | 93 | G → W in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964885EnsemblClinVar. | 1 | |
Natural variantiVAR_004994 | 96 | G → C in NDI. 2 Publications | 1 | |
Natural variantiVAR_019274 | 96 | G → D in NDI. 1 Publication | 1 | |
Natural variantiVAR_015271 | 96 | G → V in NDI. Corresponds to variant dbSNP:rs121964886EnsemblClinVar. | 1 | |
Natural variantiVAR_015272 | 97 | R → C in NDI. | 1 | |
Natural variantiVAR_015273 | 97 | R → P in NDI. 1 Publication | 1 | |
Natural variantiVAR_015274 | 98 | C → G in NDI. 1 Publication | 1 | |
Natural variantiVAR_029998 | 98 | C → S in NDI. 1 Publication | 1 | |
Natural variantiVAR_029999 | 99 | A → P in NDI. 1 Publication | 1 | |
Natural variantiVAR_015275 | 104 | C → F in NDI. 1 Publication | 1 | |
Natural variantiVAR_019275 | 104 | C → G in NDI. 1 Publication | 1 | |
Natural variantiVAR_015276 | 105 | C → R in NDI. 1 Publication | 1 | |
Natural variantiVAR_015279 | 105 | C → Y in NDI. 1 Publication | 1 | |
Natural variantiVAR_015277 | 116 | C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 PublicationsCorresponds to variant dbSNP:rs74315383EnsemblClinVar. | 1 | |
Natural variantiVAR_015278 | 116 | C → R in NDI. 1 Publication | 1 | |
Natural variantiVAR_019276 | 116 | C → W in NDI. 1 Publication | 1 | |
Natural variantiVAR_011895 | 119 | G → V1 PublicationCorresponds to variant dbSNP:rs1051744Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11166 Genomic DNA Translation: AAA98772.1 M25647 mRNA Translation: AAA61291.1 X03172 mRNA Translation: CAA26935.1 X62890 Genomic DNA Translation: CAA44681.1 AF031476 mRNA Translation: AAB86629.1 AL160414 Genomic DNA No translation available. X62891 Genomic DNA Translation: CAA44682.1 BC126196 mRNA Translation: AAI26197.1 BC126224 mRNA Translation: AAI26225.1 |
CCDSi | CCDS13045.1 |
PIRi | A39269 B94676, NVHU2 |
RefSeqi | NP_000481.2, NM_000490.4 XP_011527569.1, XM_011529267.1 |
Genome annotation databases
Ensembli | ENST00000380293; ENSP00000369647; ENSG00000101200 |
GeneIDi | 551 |
KEGGi | hsa:551 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Vasopressin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11166 Genomic DNA Translation: AAA98772.1 M25647 mRNA Translation: AAA61291.1 X03172 mRNA Translation: CAA26935.1 X62890 Genomic DNA Translation: CAA44681.1 AF031476 mRNA Translation: AAB86629.1 AL160414 Genomic DNA No translation available. X62891 Genomic DNA Translation: CAA44682.1 BC126196 mRNA Translation: AAI26197.1 BC126224 mRNA Translation: AAI26225.1 |
CCDSi | CCDS13045.1 |
PIRi | A39269 B94676, NVHU2 |
RefSeqi | NP_000481.2, NM_000490.4 XP_011527569.1, XM_011529267.1 |
3D structure databases
SMRi | P01185 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107032, 26 interactors |
IntActi | P01185, 21 interactors |
STRINGi | 9606.ENSP00000369647 |
PTM databases
GlyGeni | P01185, 1 site |
iPTMneti | P01185 |
PhosphoSitePlusi | P01185 |
Polymorphism and mutation databases
BioMutai | AVP |
DMDMi | 128083 |
Proteomic databases
MassIVEi | P01185 |
PaxDbi | P01185 |
PeptideAtlasi | P01185 |
PRIDEi | P01185 |
ProteomicsDBi | 51342 |
Protocols and materials databases
Antibodypediai | 7264, 303 antibodies |
Genome annotation databases
Ensembli | ENST00000380293; ENSP00000369647; ENSG00000101200 |
GeneIDi | 551 |
KEGGi | hsa:551 |
Organism-specific databases
CTDi | 551 |
DisGeNETi | 551 |
EuPathDBi | HostDB:ENSG00000101200.5 |
GeneCardsi | AVP |
HGNCi | HGNC:894, AVP |
HPAi | ENSG00000101200, Tissue enriched (brain) |
MalaCardsi | AVP |
MIMi | 125700, phenotype 192340, gene |
neXtProti | NX_P01185 |
OpenTargetsi | ENSG00000101200 |
Orphaneti | 30925, Hereditary central diabetes insipidus |
PharmGKBi | PA25186 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S21K, Eukaryota |
GeneTreei | ENSGT00390000004511 |
HOGENOMi | CLU_125770_0_0_1 |
InParanoidi | P01185 |
OMAi | CVTEPEC |
OrthoDBi | 1548839at2759 |
PhylomeDBi | P01185 |
TreeFami | TF333018 |
Enzyme and pathway databases
PathwayCommonsi | P01185 |
Reactomei | R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-388479, Vasopressin-like receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418555, G alpha (s) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5619099, Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-879518, Transport of organic anions R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9036092, Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SIGNORi | P01185 |
Miscellaneous databases
BioGRID-ORCSi | 551, 7 hits in 841 CRISPR screens |
GeneWikii | Vasopressin |
GenomeRNAii | 551 |
Pharosi | P01185, Tbio |
PROi | PR:P01185 |
RNActi | P01185, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101200, Expressed in hypothalamus and 87 other tissues |
ExpressionAtlasi | P01185, baseline and differential |
Genevisiblei | P01185, HS |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NEU2_HUMAN | |
Accessioni | P01185Primary (citable) accession number: P01185 Secondary accession number(s): A0AV35, O14935 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | August 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 212 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations