AVP

Functionⁱ

Neurophysin 2 specifically binds vasopressin.

Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156).1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	28	Important for agonist activity on V1aR/AVPR1A1 Publication		1

GO - Molecular functionⁱ

cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
neurohypophyseal hormone activity Source: InterPro
neuropeptide hormone activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 1740104
- 8794883
V1A vasopressin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18402937
V1B vasopressin receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 1740104
ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
generation of precursor metabolites and energy
Source: ProtInc
Traceable author statementⁱ
- 1740104
G protein-coupled receptor signaling pathway Source: Reactome
grooming behavior Source: Ensembl
hyperosmotic salinity response Source: Ensembl
locomotory behavior Source: Ensembl
maternal aggressive behavior Source: Ensembl
maternal behavior Source: Ensembl
membrane organization Source: Reactome
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
negative regulation of female receptivity Source: Ensembl
negative regulation of release of cytochrome c from mitochondria
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
negative regulation of transmission of nerve impulse Source: Ensembl
penile erection Source: Ensembl
positive regulation of cell growth Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of cellular pH reduction Source: Ensembl
positive regulation of cytosolic calcium ion concentration Source: Ensembl
positive regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 18538351
positive regulation of glutamate secretion Source: Ensembl
positive regulation of peptidyl-serine phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
positive regulation of prostaglandin biosynthetic process Source: Ensembl
positive regulation of systemic arterial blood pressure Source: Ensembl
positive regulation of vasoconstriction Source: Ensembl
protein kinase C signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
regulation of renal sodium excretion Source: Ensembl
renal water homeostasis Source: Reactome
response to ethanol Source: Ensembl
response to nicotine Source: Ensembl
response to testosterone Source: Ensembl
signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
social behavior Source: Ensembl
vasoconstriction Source: UniProtKB-KW
water transport
Source: ProtInc
Traceable author statementⁱ
- 1740104

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone, Vasoactive, Vasoconstrictor

Molecular function

Hormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-388479 Vasopressin-like receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-879518 Transport of organic anions R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
SIGNORⁱ	P01185

Reactomeⁱ

R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
R-HSA-879518 Transport of organic anions
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)

SIGNORⁱ

P01185

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vasopressin-neurophysin 2-copeptin Alternative name(s): AVP-NPII Cleaved into the following 3 chains: Arg-vasopressin Alternative name(s): Arginine-vasopressin Neurophysin 2 Alternative name(s): Neurophysin-II Copeptin
Gene namesⁱ	Name:AVP Synonyms:ARVP, VP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101200.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:894 AVP
MIMⁱ	192340 gene
neXtProtⁱ	NX_P01185

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Diabetes insipidus, neurohypophyseal (NDI)27 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	28	G → V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 42-fold decrease in affinity for V1aR/AVPR1A, 2000-fold decrease in affinity for V1bR/AVPR1B, 5-fold decrease in affinity for V2R/AVPR2 and no change in affinity for oxytocin receptor (OXTR). 1 Publication		1

Keywords - Diseaseⁱ

Diabetes insipidus, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	551
MalaCards human disease database More...MalaCardsⁱ	AVP
MIMⁱ	125700 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000101200
Orphanetⁱ	30925 Hereditary central diabetes insipidus
PharmGKBⁱ	PA25186

Polymorphism and mutation databases

BioMutaⁱ	AVP
DMDMⁱ	128083

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST	19
PeptideⁱPRO_0000020515	20 – 28	Arg-vasopressin1 Publication	9
ChainⁱPRO_0000020516	32 – 124	Neurophysin 21 PublicationAdd BLAST	93
PeptideⁱPRO_0000020517	126 – 164	Copeptin1 PublicationAdd BLAST	39

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	20 ↔ 25
Modified residueⁱ	28	Glycine amide1 Publication	1
Disulfide bondⁱ	41 ↔ 85	By similarity
Disulfide bondⁱ	44 ↔ 58	By similarity
Disulfide bondⁱ	52 ↔ 75	By similarity
Disulfide bondⁱ	59 ↔ 65	By similarity
Disulfide bondⁱ	92 ↔ 104	By similarity
Disulfide bondⁱ	98 ↔ 116	By similarity
Disulfide bondⁱ	105 ↔ 110	By similarity
Glycosylationⁱ	131	N-linked (GlcNAc...) asparagine	1

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P01185
PeptideAtlas More...PeptideAtlasⁱ	P01185
PRIDEⁱ	P01185
ProteomicsDBⁱ	51342

PTM databases

iPTMnetⁱ	P01185
PhosphoSitePlusⁱ	P01185

Miscellaneous databases

PMAP-CutDBⁱ	P01185

PMAP-CutDBⁱ

P01185

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101200 Expressed in 67 organ(s), highest expression level in hypothalamus
CleanExⁱ	HS_AVP
ExpressionAtlasⁱ	P01185 baseline and differential
Genevisibleⁱ	P01185 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025318 HPA071892

HPAⁱ

CAB025318
HPA071892

Interactionⁱ

Subunit structureⁱ

Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (PubMed:18174156). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (PubMed:18174156).1 Publication

GO - Molecular functionⁱ

neurohypophyseal hormone activity Source: InterPro
neuropeptide hormone activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18402937
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 1740104
- 8794883
V1A vasopressin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18402937
V1B vasopressin receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107032, 25 interactors
IntActⁱ	P01185, 2 interactors
STRINGⁱ	9606.ENSP00000369647

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01185
SMRⁱ	P01185
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IXM5 Eukaryota ENOG4111S8B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004511
HOGENOMⁱ	HOG000113768
HOVERGENⁱ	HBG004462
InParanoidⁱ	P01185
KEGG Orthology (KO) More...KOⁱ	K05242
OMAⁱ	GLCCNSE
Database of Orthologous Groups More...OrthoDBⁱ	1548839at2759
PhylomeDBⁱ	P01185
TreeFamⁱ	TF333018

Family and domain databases

Gene3Dⁱ	2.60.9.10, 1 hit
InterProⁱ	View protein in InterPro IPR000981 Neurhyp_horm IPR036387 Neurhyp_horm_dom_sf IPR022423 Neurohypophysial_hormone_CS
PANTHERⁱ	PTHR11681 PTHR11681, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00220 Hormone_4, 1 hit PF00184 Hormone_5, 1 hit
PIRSFⁱ	PIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSⁱ	PR00831 NEUROPHYSIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD001676 Neurhyp_horm, 1 hit
SMARTⁱ	View protein in SMART SM00003 NH, 1 hit
SUPFAMⁱ	SSF49606 SSF49606, 1 hit
PROSITEⁱ	View protein in PROSITE PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01185-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPDTMLPACF LGLLAFSSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG 
        60         70         80         90        100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAA 
       110        120        130        140        150
FGVCCNDESC VTEPECREGF HRRARASDRS NATQLDGPAG ALLLRLVQLA 
       160 
GAPEPFEPAQ PDAY

Length:164

Mass (Da):17,325

Last modified:August 1, 1992 - v2

Checksum:ⁱ8F5EF9834700B9AE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	11	L → P in AAA98772 (PubMed:2991279).Curated		1
Sequence conflictⁱ	48	G → D in AAB86629 (Ref. 5) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_004980	17	S → F in NDI. 1 Publication	1
Natural variantⁱVAR_004981	19	A → T in NDI; probably causes insufficient processing of precursor. 6 PublicationsCorresponds to variant dbSNP:rs387906511EnsemblClinVar.	1
Natural variantⁱVAR_004982	19	A → V in NDI. 2 PublicationsCorresponds to variant dbSNP:rs387906512EnsemblClinVar.	1
Natural variantⁱVAR_015262	21	Y → H in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964893EnsemblClinVar.	1
Natural variantⁱVAR_015263	26	P → L in NDI; weakly active. 1 PublicationCorresponds to variant dbSNP:rs142886338Ensembl.	1
Natural variantⁱVAR_004983	45	G → R in NDI. 1 Publication	1
Natural variantⁱVAR_004984	48	G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964883EnsemblClinVar.	1
Natural variantⁱVAR_004985	51	R → C in NDI. 1 Publication	1
Natural variantⁱVAR_015264	52	C → R in NDI.	1
Natural variantⁱVAR_015265	54	G → R in NDI. 3 PublicationsCorresponds to variant dbSNP:rs121964888EnsemblClinVar.	1
Natural variantⁱVAR_015266	54	G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964887EnsemblClinVar.	1
Natural variantⁱVAR_004986	55	P → L in NDI. 1 Publication	1
Natural variantⁱVAR_029997	58	C → F in NDI. 1 Publication	1
Natural variantⁱVAR_015267	59	C → R in NDI.	1
Natural variantⁱVAR_015268	59	C → Y in NDI. 1 Publication	1
Natural variantⁱVAR_019273	67	V → A in NDI. 1 PublicationCorresponds to variant dbSNP:rs28934878EnsemblClinVar.	1
Natural variantⁱVAR_004988	78	E → G in NDI. 2 Publications	1
Natural variantⁱVAR_004987	78	Missing in NDI. 2 Publications	1
Natural variantⁱVAR_004989	81	L → P in NDI. 1 Publication	1
Natural variantⁱVAR_011894	82	P → L. Corresponds to variant dbSNP:rs5195Ensembl.	1
Natural variantⁱVAR_015269	87	S → F in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964890EnsemblClinVar.	1
Natural variantⁱVAR_004990	88	G → R in NDI. 1 Publication	1
Natural variantⁱVAR_004991	88	G → S in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964882EnsemblClinVar.	1
Natural variantⁱVAR_004992	92	C → S in NDI. 2 Publications	1
Natural variantⁱVAR_015270	92	C → Y in NDI. 2 PublicationsCorresponds to variant dbSNP:rs121964891EnsemblClinVar.	1
Natural variantⁱVAR_004993	93	G → W in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964885EnsemblClinVar.	1
Natural variantⁱVAR_004994	96	G → C in NDI. 2 Publications	1
Natural variantⁱVAR_019274	96	G → D in NDI. 1 Publication	1
Natural variantⁱVAR_015271	96	G → V in NDI. Corresponds to variant dbSNP:rs121964886EnsemblClinVar.	1
Natural variantⁱVAR_015272	97	R → C in NDI.	1
Natural variantⁱVAR_015273	97	R → P in NDI. 1 Publication	1
Natural variantⁱVAR_015274	98	C → G in NDI. 1 Publication	1
Natural variantⁱVAR_029998	98	C → S in NDI. 1 Publication	1
Natural variantⁱVAR_029999	99	A → P in NDI. 1 Publication	1
Natural variantⁱVAR_015275	104	C → F in NDI. 1 Publication	1
Natural variantⁱVAR_019275	104	C → G in NDI. 1 Publication	1
Natural variantⁱVAR_015276	105	C → R in NDI. 1 Publication	1
Natural variantⁱVAR_015279	105	C → Y in NDI. 1 Publication	1
Natural variantⁱVAR_015277	116	C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 PublicationsCorresponds to variant dbSNP:rs74315383EnsemblClinVar.	1
Natural variantⁱVAR_015278	116	C → R in NDI. 1 Publication	1
Natural variantⁱVAR_019276	116	C → W in NDI. 1 Publication	1
Natural variantⁱVAR_011895	119	G → V1 PublicationCorresponds to variant dbSNP:rs1051744Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11166 Genomic DNA Translation: AAA98772.1 M25647 mRNA Translation: AAA61291.1 X03172 mRNA Translation: CAA26935.1 X62890 Genomic DNA Translation: CAA44681.1 AF031476 mRNA Translation: AAB86629.1 AL160414 Genomic DNA No translation available. X62891 Genomic DNA Translation: CAA44682.1 BC126196 mRNA Translation: AAI26197.1 BC126224 mRNA Translation: AAI26225.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13045.1
PIRⁱ	A39269 B94676 NVHU2
NCBI Reference Sequences More...RefSeqⁱ	NP_000481.2, NM_000490.4 XP_011527569.1, XM_011529267.1
UniGeneⁱ	Hs.89648

Genome annotation databases

Ensemblⁱ	ENST00000380293; ENSP00000369647; ENSG00000101200
GeneIDⁱ	551
KEGGⁱ	hsa:551

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01185	Arginine vasopressin (Neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) (Fragment)		HUMAN		164	UniRef100_P01185

Protein	Similar proteins		Species	Score	Length	Source
P01185	Arginine vasopressin (Neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) (Fragment)		HUMAN		164	UniRef90_P01185
vasopressin-neurophysin 2-copeptin		Florida manatee		166
Arginine vasopressin		MACMU		164
Arginine vasopressin		CHLSB		164
Arginine vasopressin		MACFA		164
+9

Protein	Similar proteins		Species	Score	Length	Source
P01185	Arginine vasopressin (Neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) (Fragment)		HUMAN		164	UniRef50_P01185
vasopressin-neurophysin 2-copeptin		Florida manatee		166
Arginine vasopressin		MACMU		164
Arginine vasopressin		CHLSB		164
Arginine vasopressin		MACFA		164
+104

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Vasopressin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11166 Genomic DNA Translation: AAA98772.1 M25647 mRNA Translation: AAA61291.1 X03172 mRNA Translation: CAA26935.1 X62890 Genomic DNA Translation: CAA44681.1 AF031476 mRNA Translation: AAB86629.1 AL160414 Genomic DNA No translation available. X62891 Genomic DNA Translation: CAA44682.1 BC126196 mRNA Translation: AAI26197.1 BC126224 mRNA Translation: AAI26225.1
CCDSⁱ	CCDS13045.1
PIRⁱ	A39269 B94676 NVHU2
RefSeqⁱ	NP_000481.2, NM_000490.4 XP_011527569.1, XM_011529267.1
UniGeneⁱ	Hs.89648

3D structure databases

ProteinModelPortalⁱ	P01185
SMRⁱ	P01185
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107032, 25 interactors
IntActⁱ	P01185, 2 interactors
STRINGⁱ	9606.ENSP00000369647

PTM databases

iPTMnetⁱ	P01185
PhosphoSitePlusⁱ	P01185

Polymorphism and mutation databases

BioMutaⁱ	AVP
DMDMⁱ	128083

Proteomic databases

PaxDbⁱ	P01185
PeptideAtlasⁱ	P01185
PRIDEⁱ	P01185
ProteomicsDBⁱ	51342

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000380293; ENSP00000369647; ENSG00000101200
GeneIDⁱ	551
KEGGⁱ	hsa:551

Organism-specific databases

CTDⁱ	551
DisGeNETⁱ	551
EuPathDBⁱ	HostDB:ENSG00000101200.5
GeneCardsⁱ	AVP
HGNCⁱ	HGNC:894 AVP
HPAⁱ	CAB025318 HPA071892
MalaCardsⁱ	AVP
MIMⁱ	125700 phenotype 192340 gene
neXtProtⁱ	NX_P01185
OpenTargetsⁱ	ENSG00000101200
Orphanetⁱ	30925 Hereditary central diabetes insipidus
PharmGKBⁱ	PA25186
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXM5 Eukaryota ENOG4111S8B LUCA
GeneTreeⁱ	ENSGT00390000004511
HOGENOMⁱ	HOG000113768
HOVERGENⁱ	HBG004462
InParanoidⁱ	P01185
KOⁱ	K05242
OMAⁱ	GLCCNSE
OrthoDBⁱ	1548839at2759
PhylomeDBⁱ	P01185
TreeFamⁱ	TF333018

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-388479 Vasopressin-like receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) R-HSA-879518 Transport of organic anions R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
SIGNORⁱ	P01185

Reactomeⁱ

R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
R-HSA-879518 Transport of organic anions
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)

SIGNORⁱ

P01185

Miscellaneous databases

GeneWikiⁱ	Vasopressin
GenomeRNAiⁱ	551
PMAP-CutDBⁱ	P01185
Protein Ontology More...PROⁱ	PR:P01185
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101200 Expressed in 67 organ(s), highest expression level in hypothalamus
CleanExⁱ	HS_AVP
ExpressionAtlasⁱ	P01185 baseline and differential
Genevisibleⁱ	P01185 HS

Family and domain databases

Gene3Dⁱ	2.60.9.10, 1 hit
InterProⁱ	View protein in InterPro IPR000981 Neurhyp_horm IPR036387 Neurhyp_horm_dom_sf IPR022423 Neurohypophysial_hormone_CS
PANTHERⁱ	PTHR11681 PTHR11681, 1 hit
Pfamⁱ	View protein in Pfam PF00220 Hormone_4, 1 hit PF00184 Hormone_5, 1 hit
PIRSFⁱ	PIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSⁱ	PR00831 NEUROPHYSIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD001676 Neurhyp_horm, 1 hit
SMARTⁱ	View protein in SMART SM00003 NH, 1 hit
SUPFAMⁱ	SSF49606 SSF49606, 1 hit
PROSITEⁱ	View protein in PROSITE PS00264 NEUROHYPOPHYS_HORM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEU2_HUMAN
Accessionⁱ	P01185Primary (citable) accession number: P01185 Secondary accession number(s): A0AV35, O14935
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	August 1, 1992
	Last modified:	January 16, 2019
	This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

UniProtKB

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UniRef

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Supporting data

UniProtKB - P01185 (NEU2_HUMAN)

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Vasopressin-neurophysin 2-copeptin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ