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Entry version 200 (13 Feb 2019)
Sequence version 2 (01 Aug 1992)
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Protein

Vasopressin-neurophysin 2-copeptin

Gene

AVP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei28Important for agonist activity on V1aR/AVPR1A1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
R-HSA-879518 Transport of organic anions
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01185

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AVP
Synonyms:ARVP, VP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101200.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:894 AVP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
192340 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01185

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diabetes insipidus, neurohypophyseal (NDI)27 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood.
See also OMIM:125700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00498017S → F in NDI. 1 Publication1
Natural variantiVAR_00498119A → T in NDI; probably causes insufficient processing of precursor. 6 PublicationsCorresponds to variant dbSNP:rs387906511EnsemblClinVar.1
Natural variantiVAR_00498219A → V in NDI. 2 PublicationsCorresponds to variant dbSNP:rs387906512EnsemblClinVar.1
Natural variantiVAR_01526221Y → H in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964893EnsemblClinVar.1
Natural variantiVAR_01526326P → L in NDI; weakly active. 1 PublicationCorresponds to variant dbSNP:rs142886338Ensembl.1
Natural variantiVAR_00498345G → R in NDI. 1 Publication1
Natural variantiVAR_00498448G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964883EnsemblClinVar.1
Natural variantiVAR_00498551R → C in NDI. 1 Publication1
Natural variantiVAR_01526452C → R in NDI. 1
Natural variantiVAR_01526554G → R in NDI. 3 PublicationsCorresponds to variant dbSNP:rs121964888EnsemblClinVar.1
Natural variantiVAR_01526654G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964887EnsemblClinVar.1
Natural variantiVAR_00498655P → L in NDI. 1 Publication1
Natural variantiVAR_02999758C → F in NDI. 1 Publication1
Natural variantiVAR_01526759C → R in NDI. 1
Natural variantiVAR_01526859C → Y in NDI. 1 Publication1
Natural variantiVAR_01927367V → A in NDI. 1 PublicationCorresponds to variant dbSNP:rs28934878EnsemblClinVar.1
Natural variantiVAR_00498878E → G in NDI. 2 Publications1
Natural variantiVAR_00498778Missing in NDI. 2 Publications1
Natural variantiVAR_00498981L → P in NDI. 1 Publication1
Natural variantiVAR_01526987S → F in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964890EnsemblClinVar.1
Natural variantiVAR_00499088G → R in NDI. 1 Publication1
Natural variantiVAR_00499188G → S in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964882EnsemblClinVar.1
Natural variantiVAR_00499292C → S in NDI. 2 Publications1
Natural variantiVAR_01527092C → Y in NDI. 2 PublicationsCorresponds to variant dbSNP:rs121964891EnsemblClinVar.1
Natural variantiVAR_00499393G → W in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964885EnsemblClinVar.1
Natural variantiVAR_00499496G → C in NDI. 2 Publications1
Natural variantiVAR_01927496G → D in NDI. 1 Publication1
Natural variantiVAR_01527196G → V in NDI. Corresponds to variant dbSNP:rs121964886EnsemblClinVar.1
Natural variantiVAR_01527297R → C in NDI. 1
Natural variantiVAR_01527397R → P in NDI. 1 Publication1
Natural variantiVAR_01527498C → G in NDI. 1 Publication1
Natural variantiVAR_02999898C → S in NDI. 1 Publication1
Natural variantiVAR_02999999A → P in NDI. 1 Publication1
Natural variantiVAR_015275104C → F in NDI. 1 Publication1
Natural variantiVAR_019275104C → G in NDI. 1 Publication1
Natural variantiVAR_015276105C → R in NDI. 1 Publication1
Natural variantiVAR_015279105C → Y in NDI. 1 Publication1
Natural variantiVAR_015277116C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 PublicationsCorresponds to variant dbSNP:rs74315383EnsemblClinVar.1
Natural variantiVAR_015278116C → R in NDI. 1 Publication1
Natural variantiVAR_019276116C → W in NDI. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28G → V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 42-fold decrease in affinity for V1aR/AVPR1A, 2000-fold decrease in affinity for V1bR/AVPR1B, 5-fold decrease in affinity for V2R/AVPR2 and no change in affinity for oxytocin receptor (OXTR). 1 Publication1

Keywords - Diseasei

Diabetes insipidus, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
551

MalaCards human disease database

More...
MalaCardsi
AVP
MIMi125700 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000101200

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
30925 Hereditary central diabetes insipidus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25186

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AVP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
128083

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002051520 – 28Arg-vasopressin1 Publication9
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002051632 – 124Neurophysin 21 PublicationAdd BLAST93
PeptideiPRO_0000020517126 – 164Copeptin1 PublicationAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi20 ↔ 25
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28Glycine amide1 Publication1
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi131N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P01185

PeptideAtlas

More...
PeptideAtlasi
P01185

PRoteomics IDEntifications database

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PRIDEi
P01185

ProteomicsDB human proteome resource

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ProteomicsDBi
51342

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01185

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01185

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01185

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101200 Expressed in 67 organ(s), highest expression level in hypothalamus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P01185 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025318
HPA071892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (PubMed:18174156). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (PubMed:18174156).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107032, 25 interactors

Protein interaction database and analysis system

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IntActi
P01185, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000369647

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01185

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01185

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXM5 Eukaryota
ENOG4111S8B LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000004511

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113768

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004462

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01185

KEGG Orthology (KO)

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KOi
K05242

Identification of Orthologs from Complete Genome Data

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OMAi
GLCCNSE

Database of Orthologous Groups

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OrthoDBi
1548839at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P01185

TreeFam database of animal gene trees

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TreeFami
TF333018

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.9.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11681 PTHR11681, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001815 Nonapeptide_hormone_precursor, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00831 NEUROPHYSIN

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00003 NH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49606 SSF49606, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01185-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDTMLPACF LGLLAFSSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAA
110 120 130 140 150
FGVCCNDESC VTEPECREGF HRRARASDRS NATQLDGPAG ALLLRLVQLA
160
GAPEPFEPAQ PDAY
Length:164
Mass (Da):17,325
Last modified:August 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F5EF9834700B9AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11L → P in AAA98772 (PubMed:2991279).Curated1
Sequence conflicti48G → D in AAB86629 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00498017S → F in NDI. 1 Publication1
Natural variantiVAR_00498119A → T in NDI; probably causes insufficient processing of precursor. 6 PublicationsCorresponds to variant dbSNP:rs387906511EnsemblClinVar.1
Natural variantiVAR_00498219A → V in NDI. 2 PublicationsCorresponds to variant dbSNP:rs387906512EnsemblClinVar.1
Natural variantiVAR_01526221Y → H in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964893EnsemblClinVar.1
Natural variantiVAR_01526326P → L in NDI; weakly active. 1 PublicationCorresponds to variant dbSNP:rs142886338Ensembl.1
Natural variantiVAR_00498345G → R in NDI. 1 Publication1
Natural variantiVAR_00498448G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964883EnsemblClinVar.1
Natural variantiVAR_00498551R → C in NDI. 1 Publication1
Natural variantiVAR_01526452C → R in NDI. 1
Natural variantiVAR_01526554G → R in NDI. 3 PublicationsCorresponds to variant dbSNP:rs121964888EnsemblClinVar.1
Natural variantiVAR_01526654G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964887EnsemblClinVar.1
Natural variantiVAR_00498655P → L in NDI. 1 Publication1
Natural variantiVAR_02999758C → F in NDI. 1 Publication1
Natural variantiVAR_01526759C → R in NDI. 1
Natural variantiVAR_01526859C → Y in NDI. 1 Publication1
Natural variantiVAR_01927367V → A in NDI. 1 PublicationCorresponds to variant dbSNP:rs28934878EnsemblClinVar.1
Natural variantiVAR_00498878E → G in NDI. 2 Publications1
Natural variantiVAR_00498778Missing in NDI. 2 Publications1
Natural variantiVAR_00498981L → P in NDI. 1 Publication1
Natural variantiVAR_01189482P → L. Corresponds to variant dbSNP:rs5195Ensembl.1
Natural variantiVAR_01526987S → F in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964890EnsemblClinVar.1
Natural variantiVAR_00499088G → R in NDI. 1 Publication1
Natural variantiVAR_00499188G → S in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964882EnsemblClinVar.1
Natural variantiVAR_00499292C → S in NDI. 2 Publications1
Natural variantiVAR_01527092C → Y in NDI. 2 PublicationsCorresponds to variant dbSNP:rs121964891EnsemblClinVar.1
Natural variantiVAR_00499393G → W in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964885EnsemblClinVar.1
Natural variantiVAR_00499496G → C in NDI. 2 Publications1
Natural variantiVAR_01927496G → D in NDI. 1 Publication1
Natural variantiVAR_01527196G → V in NDI. Corresponds to variant dbSNP:rs121964886EnsemblClinVar.1
Natural variantiVAR_01527297R → C in NDI. 1
Natural variantiVAR_01527397R → P in NDI. 1 Publication1
Natural variantiVAR_01527498C → G in NDI. 1 Publication1
Natural variantiVAR_02999898C → S in NDI. 1 Publication1
Natural variantiVAR_02999999A → P in NDI. 1 Publication1
Natural variantiVAR_015275104C → F in NDI. 1 Publication1
Natural variantiVAR_019275104C → G in NDI. 1 Publication1
Natural variantiVAR_015276105C → R in NDI. 1 Publication1
Natural variantiVAR_015279105C → Y in NDI. 1 Publication1
Natural variantiVAR_015277116C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 PublicationsCorresponds to variant dbSNP:rs74315383EnsemblClinVar.1
Natural variantiVAR_015278116C → R in NDI. 1 Publication1
Natural variantiVAR_019276116C → W in NDI. 1 Publication1
Natural variantiVAR_011895119G → V1 PublicationCorresponds to variant dbSNP:rs1051744Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M11166 Genomic DNA Translation: AAA98772.1
M25647 mRNA Translation: AAA61291.1
X03172 mRNA Translation: CAA26935.1
X62890 Genomic DNA Translation: CAA44681.1
AF031476 mRNA Translation: AAB86629.1
AL160414 Genomic DNA No translation available.
X62891 Genomic DNA Translation: CAA44682.1
BC126196 mRNA Translation: AAI26197.1
BC126224 mRNA Translation: AAI26225.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13045.1

Protein sequence database of the Protein Information Resource

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PIRi
A39269
B94676 NVHU2

NCBI Reference Sequences

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RefSeqi
NP_000481.2, NM_000490.4
XP_011527569.1, XM_011529267.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.89648

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000380293; ENSP00000369647; ENSG00000101200

Database of genes from NCBI RefSeq genomes

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GeneIDi
551

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:551

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Vasopressin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11166 Genomic DNA Translation: AAA98772.1
M25647 mRNA Translation: AAA61291.1
X03172 mRNA Translation: CAA26935.1
X62890 Genomic DNA Translation: CAA44681.1
AF031476 mRNA Translation: AAB86629.1
AL160414 Genomic DNA No translation available.
X62891 Genomic DNA Translation: CAA44682.1
BC126196 mRNA Translation: AAI26197.1
BC126224 mRNA Translation: AAI26225.1
CCDSiCCDS13045.1
PIRiA39269
B94676 NVHU2
RefSeqiNP_000481.2, NM_000490.4
XP_011527569.1, XM_011529267.1
UniGeneiHs.89648

3D structure databases

ProteinModelPortaliP01185
SMRiP01185
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107032, 25 interactors
IntActiP01185, 2 interactors
STRINGi9606.ENSP00000369647

PTM databases

iPTMnetiP01185
PhosphoSitePlusiP01185

Polymorphism and mutation databases

BioMutaiAVP
DMDMi128083

Proteomic databases

PaxDbiP01185
PeptideAtlasiP01185
PRIDEiP01185
ProteomicsDBi51342

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380293; ENSP00000369647; ENSG00000101200
GeneIDi551
KEGGihsa:551

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
551
DisGeNETi551
EuPathDBiHostDB:ENSG00000101200.5

GeneCards: human genes, protein and diseases

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GeneCardsi
AVP
HGNCiHGNC:894 AVP
HPAiCAB025318
HPA071892
MalaCardsiAVP
MIMi125700 phenotype
192340 gene
neXtProtiNX_P01185
OpenTargetsiENSG00000101200
Orphaneti30925 Hereditary central diabetes insipidus
PharmGKBiPA25186

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXM5 Eukaryota
ENOG4111S8B LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP01185
KOiK05242
OMAiGLCCNSE
OrthoDBi1548839at2759
PhylomeDBiP01185
TreeFamiTF333018

Enzyme and pathway databases

ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
R-HSA-879518 Transport of organic anions
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
SIGNORiP01185

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Vasopressin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
551
PMAP-CutDBiP01185

Protein Ontology

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PROi
PR:P01185

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101200 Expressed in 67 organ(s), highest expression level in hypothalamus
GenevisibleiP01185 HS

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEU2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01185
Secondary accession number(s): A0AV35, O14935
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: February 13, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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