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Protein

Vasopressin-neurophysin 2-copeptin

Gene

AVP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (PubMed:18174156).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei28Important for agonist activity on V1aR/AVPR1A1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5619099 Defective AVP causes neurohypophyseal diabetes insipidus (NDI)
R-HSA-879518 Transport of organic anions
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP causes neurohypophyseal diabetes insipidus (NDI)
SIGNORiP01185

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-II
Gene namesi
Name:AVP
Synonyms:ARVP, VP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101200.5
HGNCiHGNC:894 AVP
MIMi192340 gene
neXtProtiNX_P01185

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Diabetes insipidus, neurohypophyseal (NDI)27 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood.
See also OMIM:125700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00498017S → F in NDI. 1 Publication1
Natural variantiVAR_00498119A → T in NDI; probably causes insufficient processing of precursor. 6 PublicationsCorresponds to variant dbSNP:rs387906511EnsemblClinVar.1
Natural variantiVAR_00498219A → V in NDI. 2 PublicationsCorresponds to variant dbSNP:rs387906512EnsemblClinVar.1
Natural variantiVAR_01526221Y → H in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964893EnsemblClinVar.1
Natural variantiVAR_01526326P → L in NDI; weakly active. 1 PublicationCorresponds to variant dbSNP:rs142886338Ensembl.1
Natural variantiVAR_00498345G → R in NDI. 1 Publication1
Natural variantiVAR_00498448G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964883EnsemblClinVar.1
Natural variantiVAR_00498551R → C in NDI. 1 Publication1
Natural variantiVAR_01526452C → R in NDI. 1
Natural variantiVAR_01526554G → R in NDI. 3 PublicationsCorresponds to variant dbSNP:rs121964888EnsemblClinVar.1
Natural variantiVAR_01526654G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964887EnsemblClinVar.1
Natural variantiVAR_00498655P → L in NDI. 1 Publication1
Natural variantiVAR_02999758C → F in NDI. 1 Publication1
Natural variantiVAR_01526759C → R in NDI. 1
Natural variantiVAR_01526859C → Y in NDI. 1 Publication1
Natural variantiVAR_01927367V → A in NDI. 1 PublicationCorresponds to variant dbSNP:rs28934878EnsemblClinVar.1
Natural variantiVAR_00498878E → G in NDI. 2 Publications1
Natural variantiVAR_00498778Missing in NDI. 2 Publications1
Natural variantiVAR_00498981L → P in NDI. 1 Publication1
Natural variantiVAR_01526987S → F in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964890EnsemblClinVar.1
Natural variantiVAR_00499088G → R in NDI. 1 Publication1
Natural variantiVAR_00499188G → S in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964882EnsemblClinVar.1
Natural variantiVAR_00499292C → S in NDI. 2 Publications1
Natural variantiVAR_01527092C → Y in NDI. 2 PublicationsCorresponds to variant dbSNP:rs121964891EnsemblClinVar.1
Natural variantiVAR_00499393G → W in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964885EnsemblClinVar.1
Natural variantiVAR_00499496G → C in NDI. 2 Publications1
Natural variantiVAR_01927496G → D in NDI. 1 Publication1
Natural variantiVAR_01527196G → V in NDI. Corresponds to variant dbSNP:rs121964886EnsemblClinVar.1
Natural variantiVAR_01527297R → C in NDI. 1
Natural variantiVAR_01527397R → P in NDI. 1 Publication1
Natural variantiVAR_01527498C → G in NDI. 1 Publication1
Natural variantiVAR_02999898C → S in NDI. 1 Publication1
Natural variantiVAR_02999999A → P in NDI. 1 Publication1
Natural variantiVAR_015275104C → F in NDI. 1 Publication1
Natural variantiVAR_019275104C → G in NDI. 1 Publication1
Natural variantiVAR_015276105C → R in NDI. 1 Publication1
Natural variantiVAR_015279105C → Y in NDI. 1 Publication1
Natural variantiVAR_015277116C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 PublicationsCorresponds to variant dbSNP:rs74315383EnsemblClinVar.1
Natural variantiVAR_015278116C → R in NDI. 1 Publication1
Natural variantiVAR_019276116C → W in NDI. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28G → V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 42-fold decrease in affinity for V1aR/AVPR1A, 2000-fold decrease in affinity for V1bR/AVPR1B, 5-fold decrease in affinity for V2R/AVPR2 and no change in affinity for oxytocin receptor (OXTR). 1 Publication1

Keywords - Diseasei

Diabetes insipidus, Disease mutation

Organism-specific databases

DisGeNETi551
MalaCardsiAVP
MIMi125700 phenotype
OpenTargetsiENSG00000101200
Orphaneti30925 Hereditary central diabetes insipidus
PharmGKBiPA25186

Polymorphism and mutation databases

BioMutaiAVP
DMDMi128083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
PeptideiPRO_000002051520 – 28Arg-vasopressin1 Publication9
ChainiPRO_000002051632 – 124Neurophysin 21 PublicationAdd BLAST93
PeptideiPRO_0000020517126 – 164Copeptin1 PublicationAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 25
Modified residuei28Glycine amide1 Publication1
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity
Glycosylationi131N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01185
PeptideAtlasiP01185
PRIDEiP01185
ProteomicsDBi51342

PTM databases

iPTMnetiP01185
PhosphoSitePlusiP01185

Miscellaneous databases

PMAP-CutDBiP01185

Expressioni

Gene expression databases

BgeeiENSG00000101200 Expressed in 67 organ(s), highest expression level in hypothalamus
CleanExiHS_AVP
ExpressionAtlasiP01185 baseline and differential
GenevisibleiP01185 HS

Organism-specific databases

HPAiCAB025318
HPA071892

Interactioni

Subunit structurei

Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (PubMed:18174156). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (PubMed:18174156).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107032, 25 interactors
IntActiP01185, 2 interactors
STRINGi9606.ENSP00000369647

Structurei

3D structure databases

ProteinModelPortaliP01185
SMRiP01185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXM5 Eukaryota
ENOG4111S8B LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP01185
KOiK05242
OMAiGLCCNSE
OrthoDBiEOG091G0V8Z
PhylomeDBiP01185
TreeFamiTF333018

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01185-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDTMLPACF LGLLAFSSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAA
110 120 130 140 150
FGVCCNDESC VTEPECREGF HRRARASDRS NATQLDGPAG ALLLRLVQLA
160
GAPEPFEPAQ PDAY
Length:164
Mass (Da):17,325
Last modified:August 1, 1992 - v2
Checksum:i8F5EF9834700B9AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11L → P in AAA98772 (PubMed:2991279).Curated1
Sequence conflicti48G → D in AAB86629 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00498017S → F in NDI. 1 Publication1
Natural variantiVAR_00498119A → T in NDI; probably causes insufficient processing of precursor. 6 PublicationsCorresponds to variant dbSNP:rs387906511EnsemblClinVar.1
Natural variantiVAR_00498219A → V in NDI. 2 PublicationsCorresponds to variant dbSNP:rs387906512EnsemblClinVar.1
Natural variantiVAR_01526221Y → H in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964893EnsemblClinVar.1
Natural variantiVAR_01526326P → L in NDI; weakly active. 1 PublicationCorresponds to variant dbSNP:rs142886338Ensembl.1
Natural variantiVAR_00498345G → R in NDI. 1 Publication1
Natural variantiVAR_00498448G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964883EnsemblClinVar.1
Natural variantiVAR_00498551R → C in NDI. 1 Publication1
Natural variantiVAR_01526452C → R in NDI. 1
Natural variantiVAR_01526554G → R in NDI. 3 PublicationsCorresponds to variant dbSNP:rs121964888EnsemblClinVar.1
Natural variantiVAR_01526654G → V in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964887EnsemblClinVar.1
Natural variantiVAR_00498655P → L in NDI. 1 Publication1
Natural variantiVAR_02999758C → F in NDI. 1 Publication1
Natural variantiVAR_01526759C → R in NDI. 1
Natural variantiVAR_01526859C → Y in NDI. 1 Publication1
Natural variantiVAR_01927367V → A in NDI. 1 PublicationCorresponds to variant dbSNP:rs28934878EnsemblClinVar.1
Natural variantiVAR_00498878E → G in NDI. 2 Publications1
Natural variantiVAR_00498778Missing in NDI. 2 Publications1
Natural variantiVAR_00498981L → P in NDI. 1 Publication1
Natural variantiVAR_01189482P → L. Corresponds to variant dbSNP:rs5195Ensembl.1
Natural variantiVAR_01526987S → F in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964890EnsemblClinVar.1
Natural variantiVAR_00499088G → R in NDI. 1 Publication1
Natural variantiVAR_00499188G → S in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964882EnsemblClinVar.1
Natural variantiVAR_00499292C → S in NDI. 2 Publications1
Natural variantiVAR_01527092C → Y in NDI. 2 PublicationsCorresponds to variant dbSNP:rs121964891EnsemblClinVar.1
Natural variantiVAR_00499393G → W in NDI. 1 PublicationCorresponds to variant dbSNP:rs121964885EnsemblClinVar.1
Natural variantiVAR_00499496G → C in NDI. 2 Publications1
Natural variantiVAR_01927496G → D in NDI. 1 Publication1
Natural variantiVAR_01527196G → V in NDI. Corresponds to variant dbSNP:rs121964886EnsemblClinVar.1
Natural variantiVAR_01527297R → C in NDI. 1
Natural variantiVAR_01527397R → P in NDI. 1 Publication1
Natural variantiVAR_01527498C → G in NDI. 1 Publication1
Natural variantiVAR_02999898C → S in NDI. 1 Publication1
Natural variantiVAR_02999999A → P in NDI. 1 Publication1
Natural variantiVAR_015275104C → F in NDI. 1 Publication1
Natural variantiVAR_019275104C → G in NDI. 1 Publication1
Natural variantiVAR_015276105C → R in NDI. 1 Publication1
Natural variantiVAR_015279105C → Y in NDI. 1 Publication1
Natural variantiVAR_015277116C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 PublicationsCorresponds to variant dbSNP:rs74315383EnsemblClinVar.1
Natural variantiVAR_015278116C → R in NDI. 1 Publication1
Natural variantiVAR_019276116C → W in NDI. 1 Publication1
Natural variantiVAR_011895119G → V1 PublicationCorresponds to variant dbSNP:rs1051744Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11166 Genomic DNA Translation: AAA98772.1
M25647 mRNA Translation: AAA61291.1
X03172 mRNA Translation: CAA26935.1
X62890 Genomic DNA Translation: CAA44681.1
AF031476 mRNA Translation: AAB86629.1
AL160414 Genomic DNA No translation available.
X62891 Genomic DNA Translation: CAA44682.1
BC126196 mRNA Translation: AAI26197.1
BC126224 mRNA Translation: AAI26225.1
CCDSiCCDS13045.1
PIRiA39269
B94676 NVHU2
RefSeqiNP_000481.2, NM_000490.4
XP_011527569.1, XM_011529267.1
UniGeneiHs.89648

Genome annotation databases

EnsembliENST00000380293; ENSP00000369647; ENSG00000101200
GeneIDi551
KEGGihsa:551

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Vasopressin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11166 Genomic DNA Translation: AAA98772.1
M25647 mRNA Translation: AAA61291.1
X03172 mRNA Translation: CAA26935.1
X62890 Genomic DNA Translation: CAA44681.1
AF031476 mRNA Translation: AAB86629.1
AL160414 Genomic DNA No translation available.
X62891 Genomic DNA Translation: CAA44682.1
BC126196 mRNA Translation: AAI26197.1
BC126224 mRNA Translation: AAI26225.1
CCDSiCCDS13045.1
PIRiA39269
B94676 NVHU2
RefSeqiNP_000481.2, NM_000490.4
XP_011527569.1, XM_011529267.1
UniGeneiHs.89648

3D structure databases

ProteinModelPortaliP01185
SMRiP01185
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107032, 25 interactors
IntActiP01185, 2 interactors
STRINGi9606.ENSP00000369647

PTM databases

iPTMnetiP01185
PhosphoSitePlusiP01185

Polymorphism and mutation databases

BioMutaiAVP
DMDMi128083

Proteomic databases

PaxDbiP01185
PeptideAtlasiP01185
PRIDEiP01185
ProteomicsDBi51342

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380293; ENSP00000369647; ENSG00000101200
GeneIDi551
KEGGihsa:551

Organism-specific databases

CTDi551
DisGeNETi551
EuPathDBiHostDB:ENSG00000101200.5
GeneCardsiAVP
HGNCiHGNC:894 AVP
HPAiCAB025318
HPA071892
MalaCardsiAVP
MIMi125700 phenotype
192340 gene
neXtProtiNX_P01185
OpenTargetsiENSG00000101200
Orphaneti30925 Hereditary central diabetes insipidus
PharmGKBiPA25186
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXM5 Eukaryota
ENOG4111S8B LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP01185
KOiK05242
OMAiGLCCNSE
OrthoDBiEOG091G0V8Z
PhylomeDBiP01185
TreeFamiTF333018

Enzyme and pathway databases

ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5619099 Defective AVP causes neurohypophyseal diabetes insipidus (NDI)
R-HSA-879518 Transport of organic anions
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9036092 Defective AVP causes neurohypophyseal diabetes insipidus (NDI)
SIGNORiP01185

Miscellaneous databases

GeneWikiiVasopressin
GenomeRNAii551
PMAP-CutDBiP01185
PROiPR:P01185
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101200 Expressed in 67 organ(s), highest expression level in hypothalamus
CleanExiHS_AVP
ExpressionAtlasiP01185 baseline and differential
GenevisibleiP01185 HS

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEU2_HUMAN
AccessioniPrimary (citable) accession number: P01185
Secondary accession number(s): A0AV35, O14935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 197 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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