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UniProtKB - P01181 (NEU2_SHEEP)
Protein
Vasopressin-neurophysin 2-copeptin
Gene
AVP
Organism
Ovis aries (Sheep)
Status
Functioni
Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (By similarity).
By similarityMiscellaneous
X's have been placed at positions 10-12 and 108 by homology with the complete sequence of the bovine precursor.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 9 | Important for agonist activity on V1aR/AVPR1ABy similarity | 1 |
GO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
GO - Biological processi
- vasoconstriction Source: UniProtKB-KW
Keywordsi
Molecular function | Hormone, Vasoactive, Vasoconstrictor |
Names & Taxonomyi
Protein namesi | Recommended name: Vasopressin-neurophysin 2-copeptinAlternative name(s): AVP-NPII Cleaved into the following 3 chains: Alternative name(s): Arginine-vasopressin Alternative name(s): Neurophysin-III |
Gene namesi | Name:AVP |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000020527 | 1 – 9 | Arg-vasopressin | 9 | |
ChainiPRO_0000020528 | 13 – 107 | Neurophysin 2Add BLAST | 95 | |
PeptideiPRO_0000020529 | 109 – 147 | CopeptinAdd BLAST | 39 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 1 ↔ 6 | |||
Modified residuei | 9 | Glycine amide1 Publication | 1 | |
Disulfide bondi | 22 ↔ 66 | By similarity | ||
Disulfide bondi | 25 ↔ 39 | By similarity | ||
Disulfide bondi | 33 ↔ 56 | By similarity | ||
Disulfide bondi | 40 ↔ 46 | By similarity | ||
Disulfide bondi | 73 ↔ 85 | By similarity | ||
Disulfide bondi | 79 ↔ 97 | By similarity | ||
Disulfide bondi | 86 ↔ 91 | By similarity | ||
Glycosylationi | 114 | N-linked (GlcNAc...) asparagine | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity).
Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).
By similarityGO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the vasopressin/oxytocin family.Curated
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01181-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
CYFQNCPRGX XXAMSDLELR QCLPCGPGGK GRCFGPSICC GDELGCFVGT
60 70 80 90 100
AEALRCQEEI YLPSPCQSGQ KPCGSGGRCA AAGICCNDES CVTEPECREG
110 120 130 140
IGFPRRVXAS DRSNATLLDG PSGALLLRLV QLAAAPEPAE PAQPGVY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Sequence conflicti | 105 | Missing AA sequence (PubMed:1236812).Curated | 1 |
Sequence databases
PIRi | B90737, NVSH2 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | B90737, NVSH2 |
3D structure databases
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NEU2_SHEEP | |
Accessioni | P01181Primary (citable) accession number: P01181 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | October 7, 2020 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families