OXT

Functionⁱ

Neurophysin 1 specifically binds oxytocin.

Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156).

1 Publication

GO - Molecular functionⁱ

neurohypophyseal hormone activity Source: InterPro
neuropeptide hormone activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
oxytocin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

drinking behavior Source: Ensembl
eating behavior Source: Ensembl
female pregnancy Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
grooming behavior Source: Ensembl
heart development Source: Ensembl
hyperosmotic salinity response Source: Ensembl
male mating behavior Source: Ensembl
maternal aggressive behavior Source: Ensembl
maternal behavior Source: Ensembl
memory Source: Ensembl
negative regulation of blood pressure Source: Ensembl
negative regulation of gastric acid secretion Source: Ensembl
negative regulation of urine volume Source: Ensembl
positive regulation of blood pressure Source: Ensembl
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- "Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure."
  Kasahara Y., Takayanagi Y., Kawada T., Itoi K., Nishimori K.
  Biosci Biotechnol Biochem 71:3122-3126(2007) [PubMed] [Europe PMC] [Abstract]
positive regulation of cytosolic calcium ion concentration Source: Ensembl
positive regulation of female receptivity Source: Ensembl
positive regulation of hindgut contraction Source: Ensembl
positive regulation of norepinephrine secretion Source: Ensembl
positive regulation of ossification Source: Ensembl
positive regulation of penile erection Source: Ensembl
positive regulation of prostaglandin secretion Source: Ensembl
positive regulation of renal sodium excretion Source: Ensembl
positive regulation of synapse assembly Source: Ensembl
positive regulation of synaptic transmission Source: Ensembl
positive regulation of uterine smooth muscle contraction Source: Ensembl
regulation of heart rate Source: Ensembl
regulation of sensory perception of pain Source: Ensembl
response to activity Source: Ensembl
response to amphetamine Source: Ensembl
response to cAMP Source: Ensembl
response to cocaine Source: Ensembl
response to electrical stimulus Source: Ensembl
response to estradiol Source: Ensembl
response to ether Source: Ensembl
response to food Source: Ensembl
response to glucocorticoid Source: Ensembl
response to peptide hormone Source: Ensembl
response to progesterone Source: Ensembl
response to prostaglandin E Source: Ensembl
response to retinoic acid Source: Ensembl
response to sucrose Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- "Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway."
  Copland J.A., Jeng Y.J., Strakova Z., Ives K.L., Hellmich M.R., Soloff M.S.
  Endocrinology 140:2258-2267(1999) [PubMed] [Europe PMC] [Abstract]
sleep Source: Ensembl
social behavior Source: Ensembl
sperm ejaculation Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

PathwayCommonsⁱ	P01178
Reactomeⁱ	R-HSA-388479, Vasopressin-like receptors R-HSA-416476, G alpha (q) signalling events
SIGNORⁱ	P01178

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oxytocin-neurophysin 1 Short name: OT-NPI Cleaved into the following 2 chains: Oxytocin Alternative name(s): Ocytocin Neurophysin 1
Gene namesⁱ	Name:OXT Synonyms:OT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8528, OXT
MIMⁱ	167050, gene
neXtProtⁱ	NX_P01178
VEuPathDBⁱ	HostDB:ENSG00000101405.3

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Pharmaceutical useⁱ

Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	28	G → V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 310-fold decrease in affinity for oxytocin receptor (OXTR), 13-fold decrease in affinity for V1aR/AVPR1A, and complete loss of affinity for V1bR/AVPR1B and V2R/AVPR2. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5020
Open Targets More...OpenTargetsⁱ	ENSG00000101405
PharmGKBⁱ	PA32857

Miscellaneous databases

Pharosⁱ	P01178, Tbio

Pharosⁱ

P01178, Tbio

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00107, Oxytocin
DrugCentral More...DrugCentralⁱ	P01178

Genetic variation databases

BioMutaⁱ	OXT
DMDMⁱ	128071

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST	19
PeptideⁱPRO_0000020495	20 – 28	Oxytocin1 Publication	9
ChainⁱPRO_0000020496	32 – 125	Neurophysin 12 PublicationsAdd BLAST	94

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	20 ↔ 25
Modified residueⁱ	28	Glycine amide1 Publication	1
Disulfide bondⁱ	41 ↔ 85	By similarity
Disulfide bondⁱ	44 ↔ 58	By similarity
Disulfide bondⁱ	52 ↔ 75	By similarity
Disulfide bondⁱ	59 ↔ 65	By similarity
Disulfide bondⁱ	92 ↔ 104	By similarity
Disulfide bondⁱ	98 ↔ 116	By similarity
Disulfide bondⁱ	105 ↔ 110	By similarity

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MassIVEⁱ	P01178
PaxDbⁱ	P01178
PeptideAtlas More...PeptideAtlasⁱ	P01178
PRIDEⁱ	P01178
ProteomicsDBⁱ	51341

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101405, Expressed in hypothalamus and 102 other tissues
ExpressionAtlasⁱ	P01178, baseline and differential
Genevisibleⁱ	P01178, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000101405, Tissue enriched (brain)

HPAⁱ

ENSG00000101405, Tissue enriched (brain)

Interactionⁱ

Subunit structureⁱ

Interacts with oxytocin receptor (Ki=1.5 nM) (PubMed:18174156).

Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM) and V2R/AVPR2 receptors (Ki=823 nM) (PubMed:18174156).

1 Publication

Binary interactionsⁱ

P01178

With	#Exp.	IntAct
DCDC2 [Q9UHG0]	3	EBI-1762651,EBI-10303987

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	111060, 17 interactors
IntActⁱ	P01178, 7 interactors
STRINGⁱ	9606.ENSP00000217386

Miscellaneous databases

RNActⁱ	P01178, protein

RNActⁱ

P01178, protein

Structureⁱ

3D structure databases

SMRⁱ	P01178
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG502S2CT, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004511
HOGENOMⁱ	CLU_125770_1_0_1
InParanoidⁱ	P01178
OMAⁱ	DMRKCLP
Database of Orthologous Groups More...OrthoDBⁱ	1548839at2759
PhylomeDBⁱ	P01178
TreeFamⁱ	TF333018

Family and domain databases

Gene3Dⁱ	2.60.9.10, 1 hit
InterProⁱ	View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS
PANTHERⁱ	PTHR11681, PTHR11681, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit
PIRSFⁱ	PIRSF001815, Nonapeptide_hormone_precursor, 1 hit
PRINTSⁱ	PR00831, NEUROPHYSIN
SMARTⁱ	View protein in SMART SM00003, NH, 1 hit
SUPFAMⁱ	SSF49606, SSF49606, 1 hit
PROSITEⁱ	View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01178-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG 
        60         70         80         90        100
RCFGPNICCA EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV 
       110        120 
LGLCCSPDGC HADPACDAEA TFSQR

Length:125

Mass (Da):12,722

Last modified:January 1, 1988 - v1

Checksum:ⁱC65BB544731A0E7C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	94	S → G in AAA59979 (PubMed:2249637).Curated	1
Sequence conflictⁱ	100 – 101	VL → AA AA sequence (PubMed:7262323).Curated	2
Sequence conflictⁱ	100	Missing in AAA98806 (PubMed:2991279).Curated	1
Sequence conflictⁱ	124	Q → L AA sequence (PubMed:7262323).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25650 mRNA Translation: AAA59977.1 M11186 Genomic DNA Translation: AAA98806.1 AY082910 Genomic DNA Translation: AAL92860.1 AL160414 Genomic DNA No translation available. BC069144 mRNA Translation: AAH69144.1 BC101841 mRNA Translation: AAI01842.1 BC101843 mRNA Translation: AAI01844.1 X03173 mRNA Translation: CAA26936.1 M62611 mRNA Translation: AAA59979.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13044.1
PIRⁱ	A94676, NFHU1
NCBI Reference Sequences More...RefSeqⁱ	NP_000906.1, NM_000915.3 XP_011527540.1, XM_011529238.1

Genome annotation databases

Ensemblⁱ	ENST00000217386; ENSP00000217386; ENSG00000101405
GeneIDⁱ	5020
KEGGⁱ	hsa:5020

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01178	Oxytocin, prepro-(Neurophysin I) (Fragment)		HUMAN		125	UniRef100_P01178

Protein	Similar proteins		Species	Score	Length	Source
P01178	Oxytocin-neurophysin 1 (Fragment)		PAPHA		85	UniRef90_P01178
Oxytocin, prepro-(Neurophysin I) (Fragment)		HUMAN		125
Oxytocin/neurophysin I prepropeptide		PAPAN		153
Uncharacterized protein		RHIBE		153
Oxytocin/neurophysin I prepropeptide		PANTR		125
+45

Protein	Similar proteins		Species	Score	Length	Source
P01178	Vasopressin-neurophysin 2-copeptin		RAT		168	UniRef50_P01186
Vasopressin-neurophysin 2-copeptin		MOUSE		168
Oxytocin-neurophysin 1		PIG		125
Oxytocin-neurophysin 1		SHEEP		125
Oxytocin-neurophysin 1 (Fragment)		PAPHA		85
+165

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Oxytocin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25650 mRNA Translation: AAA59977.1 M11186 Genomic DNA Translation: AAA98806.1 AY082910 Genomic DNA Translation: AAL92860.1 AL160414 Genomic DNA No translation available. BC069144 mRNA Translation: AAH69144.1 BC101841 mRNA Translation: AAI01842.1 BC101843 mRNA Translation: AAI01844.1 X03173 mRNA Translation: CAA26936.1 M62611 mRNA Translation: AAA59979.1
CCDSⁱ	CCDS13044.1
PIRⁱ	A94676, NFHU1
RefSeqⁱ	NP_000906.1, NM_000915.3 XP_011527540.1, XM_011529238.1

3D structure databases

SMRⁱ	P01178
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111060, 17 interactors
IntActⁱ	P01178, 7 interactors
STRINGⁱ	9606.ENSP00000217386

Chemistry databases

DrugBankⁱ	DB00107, Oxytocin
DrugCentralⁱ	P01178

Genetic variation databases

BioMutaⁱ	OXT
DMDMⁱ	128071

Proteomic databases

MassIVEⁱ	P01178
PaxDbⁱ	P01178
PeptideAtlasⁱ	P01178
PRIDEⁱ	P01178
ProteomicsDBⁱ	51341

Protocols and materials databases

Antibodypediaⁱ	7257, 250 antibodies
The DNASU plasmid repository More...DNASUⁱ	5020

Genome annotation databases

Ensemblⁱ	ENST00000217386; ENSP00000217386; ENSG00000101405
GeneIDⁱ	5020
KEGGⁱ	hsa:5020

Organism-specific databases

CTDⁱ	5020
DisGeNETⁱ	5020
GeneCardsⁱ	OXT
HGNCⁱ	HGNC:8528, OXT
HPAⁱ	ENSG00000101405, Tissue enriched (brain)
MIMⁱ	167050, gene
neXtProtⁱ	NX_P01178
OpenTargetsⁱ	ENSG00000101405
PharmGKBⁱ	PA32857
VEuPathDBⁱ	HostDB:ENSG00000101405.3
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502S2CT, Eukaryota
GeneTreeⁱ	ENSGT00390000004511
HOGENOMⁱ	CLU_125770_1_0_1
InParanoidⁱ	P01178
OMAⁱ	DMRKCLP
OrthoDBⁱ	1548839at2759
PhylomeDBⁱ	P01178
TreeFamⁱ	TF333018

Enzyme and pathway databases

PathwayCommonsⁱ	P01178
Reactomeⁱ	R-HSA-388479, Vasopressin-like receptors R-HSA-416476, G alpha (q) signalling events
SIGNORⁱ	P01178

Miscellaneous databases

BioGRID-ORCSⁱ	5020, 3 hits in 982 CRISPR screens
GeneWikiⁱ	Neurophysin_I Oxytocin
GenomeRNAiⁱ	5020
Pharosⁱ	P01178, Tbio
Protein Ontology More...PROⁱ	PR:P01178
RNActⁱ	P01178, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101405, Expressed in hypothalamus and 102 other tissues
ExpressionAtlasⁱ	P01178, baseline and differential
Genevisibleⁱ	P01178, HS

Family and domain databases

Gene3Dⁱ	2.60.9.10, 1 hit
InterProⁱ	View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS
PANTHERⁱ	PTHR11681, PTHR11681, 1 hit
Pfamⁱ	View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit
PIRSFⁱ	PIRSF001815, Nonapeptide_hormone_precursor, 1 hit
PRINTSⁱ	PR00831, NEUROPHYSIN
SMARTⁱ	View protein in SMART SM00003, NH, 1 hit
SUPFAMⁱ	SSF49606, SSF49606, 1 hit
PROSITEⁱ	View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEU1_HUMAN
Accessionⁱ	P01178Primary (citable) accession number: P01178 Secondary accession number(s): Q3MIG0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 1, 1988
	Last modified:	June 2, 2021
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P01178 (NEU1_HUMAN)

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Oxytocin-neurophysin 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P01178

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ