UniProtKB - P01178 (NEU1_HUMAN)
Protein
Oxytocin-neurophysin 1
Gene
OXT
Organism
Homo sapiens (Human)
Status
Functioni
Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156).1 Publication
GO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
- neuropeptide hormone activity Source: GO_Central
- oxytocin receptor binding Source: GO_Central
GO - Biological processi
- drinking behavior Source: Ensembl
- eating behavior Source: Ensembl
- female pregnancy Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- grooming behavior Source: Ensembl
- heart development Source: Ensembl
- hyperosmotic salinity response Source: Ensembl
- male mating behavior Source: Ensembl
- maternal aggressive behavior Source: Ensembl
- maternal behavior Source: Ensembl
- memory Source: Ensembl
- negative regulation of blood pressure Source: Ensembl
- negative regulation of gastric acid secretion Source: Ensembl
- negative regulation of urine volume Source: Ensembl
- positive regulation of blood pressure Source: Ensembl
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of female receptivity Source: Ensembl
- positive regulation of hindgut contraction Source: Ensembl
- positive regulation of norepinephrine secretion Source: Ensembl
- positive regulation of ossification Source: Ensembl
- positive regulation of penile erection Source: Ensembl
- positive regulation of prostaglandin secretion Source: Ensembl
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of synapse assembly Source: Ensembl
- positive regulation of synaptic transmission Source: Ensembl
- positive regulation of uterine smooth muscle contraction Source: Ensembl
- regulation of heart rate Source: Ensembl
- regulation of sensory perception of pain Source: Ensembl
- response to activity Source: Ensembl
- response to amphetamine Source: Ensembl
- response to cAMP Source: Ensembl
- response to cocaine Source: Ensembl
- response to electrical stimulus Source: Ensembl
- response to estradiol Source: Ensembl
- response to ether Source: Ensembl
- response to food Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to peptide hormone Source: Ensembl
- response to progesterone Source: Ensembl
- response to prostaglandin E Source: Ensembl
- response to retinoic acid Source: Ensembl
- response to sucrose Source: Ensembl
- signal transduction Source: ProtInc
- sleep Source: Ensembl
- social behavior Source: Ensembl
- sperm ejaculation Source: Ensembl
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | P01178 |
Reactomei | R-HSA-388479, Vasopressin-like receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P01178 |
Names & Taxonomyi
Protein namesi | Recommended name: Oxytocin-neurophysin 1Short name: OT-NPI Cleaved into the following 2 chains: |
Gene namesi | Name:OXT Synonyms:OT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8528, OXT |
MIMi | 167050, gene |
neXtProti | NX_P01178 |
VEuPathDBi | HostDB:ENSG00000101405.3 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- secretory granule Source: GO_Central
- terminal bouton Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Pharmaceutical usei
Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 | G → V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 310-fold decrease in affinity for oxytocin receptor (OXTR), 13-fold decrease in affinity for V1aR/AVPR1A, and complete loss of affinity for V1bR/AVPR1B and V2R/AVPR2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5020 |
OpenTargetsi | ENSG00000101405 |
PharmGKBi | PA32857 |
Miscellaneous databases
Pharosi | P01178, Tbio |
Chemistry databases
DrugBanki | DB00107, Oxytocin |
DrugCentrali | P01178 |
Genetic variation databases
BioMutai | OXT |
DMDMi | 128071 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
PeptideiPRO_0000020495 | 20 – 28 | Oxytocin1 Publication | 9 | |
ChainiPRO_0000020496 | 32 – 125 | Neurophysin 12 PublicationsAdd BLAST | 94 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 20 ↔ 25 | |||
Modified residuei | 28 | Glycine amide1 Publication | 1 | |
Disulfide bondi | 41 ↔ 85 | By similarity | ||
Disulfide bondi | 44 ↔ 58 | By similarity | ||
Disulfide bondi | 52 ↔ 75 | By similarity | ||
Disulfide bondi | 59 ↔ 65 | By similarity | ||
Disulfide bondi | 92 ↔ 104 | By similarity | ||
Disulfide bondi | 98 ↔ 116 | By similarity | ||
Disulfide bondi | 105 ↔ 110 | By similarity |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bondProteomic databases
PaxDbi | P01178 |
PeptideAtlasi | P01178 |
PRIDEi | P01178 |
ProteomicsDBi | 51341 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101405, Expressed in hypothalamus and 100 other tissues |
ExpressionAtlasi | P01178, baseline and differential |
Genevisiblei | P01178, HS |
Organism-specific databases
HPAi | ENSG00000101405, Tissue enriched (brain) |
Interactioni
Subunit structurei
Binary interactionsi
P01178
With | #Exp. | IntAct |
---|---|---|
DCDC2 [Q9UHG0] | 3 | EBI-1762651,EBI-10303987 |
GO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
- neuropeptide hormone activity Source: GO_Central
- oxytocin receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 111060, 17 interactors |
IntActi | P01178, 7 interactors |
STRINGi | 9606.ENSP00000217386 |
Miscellaneous databases
RNActi | P01178, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the vasopressin/oxytocin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S2CT, Eukaryota |
GeneTreei | ENSGT00390000004511 |
HOGENOMi | CLU_125770_1_0_1 |
InParanoidi | P01178 |
OMAi | DMRKCLP |
OrthoDBi | 1548839at2759 |
PhylomeDBi | P01178 |
TreeFami | TF333018 |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01178-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG
60 70 80 90 100
RCFGPNICCA EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV
110 120
LGLCCSPDGC HADPACDAEA TFSQR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 94 | S → G in AAA59979 (PubMed:2249637).Curated | 1 | |
Sequence conflicti | 100 – 101 | VL → AA AA sequence (PubMed:7262323).Curated | 2 | |
Sequence conflicti | 100 | Missing in AAA98806 (PubMed:2991279).Curated | 1 | |
Sequence conflicti | 124 | Q → L AA sequence (PubMed:7262323).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25650 mRNA Translation: AAA59977.1 M11186 Genomic DNA Translation: AAA98806.1 AY082910 Genomic DNA Translation: AAL92860.1 AL160414 Genomic DNA No translation available. BC069144 mRNA Translation: AAH69144.1 BC101841 mRNA Translation: AAI01842.1 BC101843 mRNA Translation: AAI01844.1 X03173 mRNA Translation: CAA26936.1 M62611 mRNA Translation: AAA59979.1 |
CCDSi | CCDS13044.1 |
PIRi | A94676, NFHU1 |
RefSeqi | NP_000906.1, NM_000915.3 XP_011527540.1, XM_011529238.1 |
Genome annotation databases
Ensembli | ENST00000217386; ENSP00000217386; ENSG00000101405 |
GeneIDi | 5020 |
KEGGi | hsa:5020 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Oxytocin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25650 mRNA Translation: AAA59977.1 M11186 Genomic DNA Translation: AAA98806.1 AY082910 Genomic DNA Translation: AAL92860.1 AL160414 Genomic DNA No translation available. BC069144 mRNA Translation: AAH69144.1 BC101841 mRNA Translation: AAI01842.1 BC101843 mRNA Translation: AAI01844.1 X03173 mRNA Translation: CAA26936.1 M62611 mRNA Translation: AAA59979.1 |
CCDSi | CCDS13044.1 |
PIRi | A94676, NFHU1 |
RefSeqi | NP_000906.1, NM_000915.3 XP_011527540.1, XM_011529238.1 |
3D structure databases
SMRi | P01178 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111060, 17 interactors |
IntActi | P01178, 7 interactors |
STRINGi | 9606.ENSP00000217386 |
Chemistry databases
DrugBanki | DB00107, Oxytocin |
DrugCentrali | P01178 |
Genetic variation databases
BioMutai | OXT |
DMDMi | 128071 |
Proteomic databases
PaxDbi | P01178 |
PeptideAtlasi | P01178 |
PRIDEi | P01178 |
ProteomicsDBi | 51341 |
Protocols and materials databases
Antibodypediai | 7257, 241 antibodies |
Genome annotation databases
Ensembli | ENST00000217386; ENSP00000217386; ENSG00000101405 |
GeneIDi | 5020 |
KEGGi | hsa:5020 |
Organism-specific databases
CTDi | 5020 |
DisGeNETi | 5020 |
GeneCardsi | OXT |
HGNCi | HGNC:8528, OXT |
HPAi | ENSG00000101405, Tissue enriched (brain) |
MIMi | 167050, gene |
neXtProti | NX_P01178 |
OpenTargetsi | ENSG00000101405 |
PharmGKBi | PA32857 |
VEuPathDBi | HostDB:ENSG00000101405.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2CT, Eukaryota |
GeneTreei | ENSGT00390000004511 |
HOGENOMi | CLU_125770_1_0_1 |
InParanoidi | P01178 |
OMAi | DMRKCLP |
OrthoDBi | 1548839at2759 |
PhylomeDBi | P01178 |
TreeFami | TF333018 |
Enzyme and pathway databases
PathwayCommonsi | P01178 |
Reactomei | R-HSA-388479, Vasopressin-like receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P01178 |
Miscellaneous databases
BioGRID-ORCSi | 5020, 3 hits in 870 CRISPR screens |
GeneWikii | Neurophysin_I Oxytocin |
GenomeRNAii | 5020 |
Pharosi | P01178, Tbio |
PROi | PR:P01178 |
RNActi | P01178, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101405, Expressed in hypothalamus and 100 other tissues |
ExpressionAtlasi | P01178, baseline and differential |
Genevisiblei | P01178, HS |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NEU1_HUMAN | |
Accessioni | P01178Primary (citable) accession number: P01178 Secondary accession number(s): Q3MIG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 1, 1988 | |
Last modified: | February 10, 2021 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Pharmaceutical, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM