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Protein

Natriuretic peptides A

Gene

Nppa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

  • hormone activity Source: RGD
  • hormone receptor binding Source: Ensembl
  • neuropeptide hormone activity Source: Ensembl
  • neuropeptide receptor binding Source: Ensembl
  • signaling receptor binding Source: RGD

GO - Biological processi

  • cardiac muscle hypertrophy in response to stress Source: Ensembl
  • cell growth involved in cardiac muscle cell development Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • cGMP biosynthetic process Source: Ensembl
  • female pregnancy Source: UniProtKB
  • heart development Source: UniProtKB
  • multicellular organismal water homeostasis Source: RGD
  • negative regulation of cell growth Source: RGD
  • negative regulation of collecting lymphatic vessel constriction Source: RGD
  • negative regulation of systemic arterial blood pressure Source: RGD
  • neuropeptide signaling pathway Source: Ensembl
  • positive regulation of cardiac muscle contraction Source: Ensembl
  • positive regulation of cGMP-mediated signaling Source: RGD
  • positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
  • positive regulation of heart rate Source: Ensembl
  • positive regulation of histamine secretion by mast cell Source: UniProtKB
  • positive regulation of potassium ion export across plasma membrane Source: BHF-UCL
  • protein folding Source: Ensembl
  • receptor guanylyl cyclase signaling pathway Source: MGI
  • regulation of atrial cardiac muscle cell membrane repolarization Source: Ensembl
  • regulation of blood pressure Source: UniProtKB
  • regulation of blood vessel size Source: UniProtKB-KW
  • regulation of body fluid levels Source: RGD
  • regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
  • regulation of high voltage-gated calcium channel activity Source: BHF-UCL
  • response to hypoxia Source: RGD
  • response to insulin Source: RGD

Keywordsi

Molecular functionHormone, Vasoactive

Enzyme and pathway databases

ReactomeiR-RNO-5578768 Physiological factors

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
Prepronatriodilatin
Cleaved into the following 6 chains:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Alternative name(s):
Atriopeptin I
Alternative name(s):
Atriopeptin II
Alternative name(s):
Atriopeptin III
Gene namesi
Name:Nppa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi3193 Nppa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4287

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PropeptideiPRO_000000150525 – 122CuratedAdd BLAST98
PeptideiPRO_0000391785123 – 150Atrial natriuretic factorBy similarityAdd BLAST28
PeptideiPRO_0000001506126 – 150Auriculin-B1 PublicationAdd BLAST25
PeptideiPRO_0000001507126 – 149Auriculin-A1 PublicationAdd BLAST24
PeptideiPRO_0000001508127 – 150Atriopeptin-31 PublicationAdd BLAST24
PeptideiPRO_0000001509127 – 149Atriopeptin-21 PublicationAdd BLAST23
PeptideiPRO_0000001510127 – 147Atriopeptin-11 PublicationAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi129 ↔ 1451 Publication

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone (By similarity).By similarity
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei122 – 123Cleavage; by CORINBy similarity2
Sitei129 – 130Cleavage; by MME1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01161
PRIDEiP01161

PTM databases

iPTMnetiP01161
PhosphoSitePlusiP01161

Miscellaneous databases

PMAP-CutDBiP01161

Expressioni

Gene expression databases

BgeeiENSRNOG00000008176
ExpressionAtlasiP01161 baseline and differential
GenevisibleiP01161 RN

Interactioni

Subunit structurei

Interacts with NPR1.1 Publication

GO - Molecular functioni

  • hormone activity Source: RGD
  • hormone receptor binding Source: Ensembl
  • neuropeptide hormone activity Source: Ensembl
  • neuropeptide receptor binding Source: Ensembl
  • signaling receptor binding Source: RGD

Protein-protein interaction databases

IntActiP01161, 1 interactor
STRINGi10116.ENSRNOP00000011005

Chemistry databases

BindingDBiP01161

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni136 – 139Combined sources4

3D structure databases

SMRiP01161
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01161

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW5F Eukaryota
ENOG410ZUY6 LUCA
GeneTreeiENSGT00510000048659
HOGENOMiHOG000033937
HOVERGENiHBG004227
InParanoidiP01161
KOiK12334
OMAiCNSFRYR
OrthoDBiEOG091G0SV3
PhylomeDBiP01161
TreeFamiTF106304

Family and domain databases

InterProiView protein in InterPro
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
IPR002407 Natriuretic_peptide_atrial
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00711 ANATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFSITKGF FLFLAFWLPG HIGANPVYSA VSNTDLMDFK NLLDHLEEKM
60 70 80 90 100
PVEDEVMPPQ ALSEQTDEAG AALSSLSEVP PWTGEVNPSQ RDGGALGRGP
110 120 130 140 150
WDPSDRSALL KSKLRALLAG PRSLRRSSCF GGRIDRIGAQ SGLGCNSFRY

RR
Length:152
Mass (Da):16,556
Last modified:July 21, 1986 - v1
Checksum:iD8AAB2191E29519F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15868 mRNA Translation: AAA40736.1
X00665 mRNA Translation: CAA25285.1
K02062 Genomic DNA Translation: AAA40735.1
X01118 mRNA Translation: CAA25586.1
M27498 mRNA Translation: AAA40737.1
PIRiA22570 AWRT
RefSeqiNP_036744.1, NM_012612.2
UniGeneiRn.2004

Genome annotation databases

EnsembliENSRNOT00000011005; ENSRNOP00000011005; ENSRNOG00000008176
GeneIDi24602
KEGGirno:24602
UCSCiRGD:3193 rat

Similar proteinsi

Entry informationi

Entry nameiANF_RAT
AccessioniPrimary (citable) accession number: P01161
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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