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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.1 Publication

GO - Molecular functioni

  • hormone receptor binding Source: UniProtKB
  • neuropeptide hormone activity Source: BHF-UCL
  • neuropeptide receptor binding Source: BHF-UCL
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive

Enzyme and pathway databases

ReactomeiR-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-5578768 Physiological factors
R-HSA-977225 Amyloid fiber formation
SIGNORiP01160

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
CDD-ANF
Cardiodilatin
Short name:
CDD
Cardiodilatin-related peptide
Short name:
CDP
Prepronatriodilatin
Cleaved into the following chain:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
Synonyms:ANP, PND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000175206.10
HGNCiHGNC:7939 NPPA
MIMi108780 gene
neXtProtiNX_P01160

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Atrial standstill 2 (ATRST2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm.
See also OMIM:615745
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071307150R → Q in ATRST2. 1 Publication1
Atrial fibrillation, familial, 6 (ATFB6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
See also OMIM:612201

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi123R → G: Loss of cleavage by CORIN. 1 Publication1

Keywords - Diseasei

Atrial fibrillation, Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi4878
MalaCardsiNPPA
MIMi612201 phenotype
615745 phenotype
Orphaneti1344 Atrial standstill
334 Familial atrial fibrillation
PharmGKBiPA256

Chemistry databases

ChEMBLiCHEMBL1293193

Polymorphism and mutation databases

BioMutaiNPPA
DMDMi113864

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
PropeptideiPRO_000000149326 – 123CuratedAdd BLAST98
PeptideiPRO_0000001494124 – 151Atrial natriuretic factor2 PublicationsAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi130 ↔ 1461 Publication

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.2 Publications
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei123 – 124Cleavage; by CORIN1 Publication2
Sitei130 – 131Cleavage; by MME1 Publication2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01160
PeptideAtlasiP01160
PRIDEiP01160
ProteomicsDBi51340

PTM databases

CarbonylDBiP01160
iPTMnetiP01160
PhosphoSitePlusiP01160

Expressioni

Gene expression databases

BgeeiENSG00000175206 Expressed in 188 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_NPPA
ExpressionAtlasiP01160 baseline and differential
GenevisibleiP01160 HS

Organism-specific databases

HPAiHPA058269

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110938, 50 interactors
IntActiP01160, 5 interactors
STRINGi9606.ENSP00000365663

Chemistry databases

BindingDBiP01160

Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00747
ProteinModelPortaliP01160
SMRiP01160
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01160

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW5F Eukaryota
ENOG410ZUY6 LUCA
HOGENOMiHOG000033937
HOVERGENiHBG004227
InParanoidiP01160
KOiK12334
PhylomeDBiP01160
TreeFamiTF106304

Family and domain databases

InterProiView protein in InterPro
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
IPR002407 Natriuretic_peptide_atrial
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00711 ANATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P01160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK
60 70 80 90 100
MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG
110 120 130 140 150
PWDSSDRSAL LKSKLRALLT APRSLRRSSC FGGRMDRIGA QSGLGCNSFR

YRR
Length:153
Mass (Da):16,708
Last modified:August 13, 1987 - v1
Checksum:iB38F03AA066A73EC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X094A0A087X094_HUMAN
Natriuretic peptides A
NPPA
152Annotation score:
B0ZBE8B0ZBE8_HUMAN
Natriuretic peptide A variant 1
NPPA
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65E → D in AAA35529 (PubMed:3158606).Curated1

Polymorphismi

There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01457932V → M. Corresponds to variant dbSNP:rs5063Ensembl.1
Natural variantiVAR_071307150R → Q in ATRST2. 1 Publication1
Natural variantiVAR_000594152 – 153Missing in allele 2. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02043 Genomic DNA Translation: AAB59379.1
M30262 mRNA Translation: AAA35669.1
X01470, X02558 Genomic DNA Translation: CAA25699.1
X01471 Genomic DNA Translation: CAA25700.2
M54951, M54947 Genomic DNA Translation: AAA35529.1
AL021155 Genomic DNA No translation available.
EU326308 Genomic DNA Translation: ACA05916.1
BC005893 mRNA Translation: AAH05893.1
K02399 Genomic DNA Translation: AAA35528.1
K02044 mRNA Translation: AAA51730.1
PIRiA22693 AWHU
RefSeqiNP_006163.1, NM_006172.3
UniGeneiHs.75640

Genome annotation databases

EnsembliENST00000376480; ENSP00000365663; ENSG00000175206
GeneIDi4878
KEGGihsa:4878
UCSCiuc001ati.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Atrial natriuretic peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02043 Genomic DNA Translation: AAB59379.1
M30262 mRNA Translation: AAA35669.1
X01470, X02558 Genomic DNA Translation: CAA25699.1
X01471 Genomic DNA Translation: CAA25700.2
M54951, M54947 Genomic DNA Translation: AAA35529.1
AL021155 Genomic DNA No translation available.
EU326308 Genomic DNA Translation: ACA05916.1
BC005893 mRNA Translation: AAH05893.1
K02399 Genomic DNA Translation: AAA35528.1
K02044 mRNA Translation: AAA51730.1
PIRiA22693 AWHU
RefSeqiNP_006163.1, NM_006172.3
UniGeneiHs.75640

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ANPNMR-A124-151[»]
1YK0X-ray2.40E129-149[»]
3N57X-ray3.03C/D124-151[»]
DisProtiDP00747
ProteinModelPortaliP01160
SMRiP01160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110938, 50 interactors
IntActiP01160, 5 interactors
STRINGi9606.ENSP00000365663

Chemistry databases

BindingDBiP01160
ChEMBLiCHEMBL1293193

PTM databases

CarbonylDBiP01160
iPTMnetiP01160
PhosphoSitePlusiP01160

Polymorphism and mutation databases

BioMutaiNPPA
DMDMi113864

Proteomic databases

PaxDbiP01160
PeptideAtlasiP01160
PRIDEiP01160
ProteomicsDBi51340

Protocols and materials databases

DNASUi4878
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376480; ENSP00000365663; ENSG00000175206
GeneIDi4878
KEGGihsa:4878
UCSCiuc001ati.4 human

Organism-specific databases

CTDi4878
DisGeNETi4878
EuPathDBiHostDB:ENSG00000175206.10
GeneCardsiNPPA
H-InvDBiHIX0199955
HGNCiHGNC:7939 NPPA
HPAiHPA058269
MalaCardsiNPPA
MIMi108780 gene
612201 phenotype
615745 phenotype
neXtProtiNX_P01160
Orphaneti1344 Atrial standstill
334 Familial atrial fibrillation
PharmGKBiPA256
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW5F Eukaryota
ENOG410ZUY6 LUCA
HOGENOMiHOG000033937
HOVERGENiHBG004227
InParanoidiP01160
KOiK12334
PhylomeDBiP01160
TreeFamiTF106304

Enzyme and pathway databases

ReactomeiR-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-5578768 Physiological factors
R-HSA-977225 Amyloid fiber formation
SIGNORiP01160

Miscellaneous databases

EvolutionaryTraceiP01160
GeneWikiiAtrial_natriuretic_peptide
GenomeRNAii4878
PROiPR:P01160
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175206 Expressed in 188 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_NPPA
ExpressionAtlasiP01160 baseline and differential
GenevisibleiP01160 HS

Family and domain databases

InterProiView protein in InterPro
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
IPR002407 Natriuretic_peptide_atrial
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00711 ANATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANF_HUMAN
AccessioniPrimary (citable) accession number: P01160
Secondary accession number(s): Q13766, Q5JZE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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