Natriuretic peptides A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• hormone activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• hormone receptor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.15

    "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
    Bennett B.D., Bennett G.L., Vitangcol R.V., Jewett J.R., Burnier J., Henzel W., Lowe D.G.
    J. Biol. Chem. 266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: RECEPTOR-BINDING.
• neuropeptide hormone activity Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
• neuropeptide receptor binding Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.16

    "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
    Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., Goeddel D.V.
    Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.

GO - Biological processⁱ

• cardiac muscle hypertrophy in response to stress Source: Ensembl
• cell growth involved in cardiac muscle cell development Source: Ensembl
• cellular protein metabolic process Source: Reactome
• cellular response to mechanical stimulus Source: Ensembl
• cGMP biosynthetic process Source: GO_CentralInferred from direct assayⁱ
  • Ref.16

    "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
    Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., Goeddel D.V.
    Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• cGMP-mediated signaling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: UniProtKB
• negative regulation of canonical Wnt signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Central role of beta-catenin in anticancer effects of cardiac hormones."
    Skelton W.P., Skelton M., Vesely D.L.
    Anticancer Res. 33:2409-2414(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell growth Source: Ensembl
• negative regulation of collecting lymphatic vessel constriction Source: Ensembl
• negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Epidermal growth factor's activation of Ras is inhibited by four cardiac hormones."
    Sun Y., Eichelbaum E.J., Lenz A., Wang H., Vesely D.L.
    Eur. J. Clin. Invest. 40:408-413(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of systemic arterial blood pressure Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neuropeptide signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle contraction Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cGMP-mediated signaling Source: Ensembl
• positive regulation of delayed rectifier potassium channel activity Source: BHF-UCLInferred from direct assayⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
  • "Atrial natriuretic factor blocks the high-threshold Ca2+ current and increases K+ current in fetal single ventricular cells."
    Bkaily G., Perron N., Wang S., Sculptoreanu A., Jacques D., Menard D.
    J. Mol. Cell. Cardiol. 25:1305-1316(1993) [PubMed] [Europe PMC] [Abstract]
• positive regulation of heart rate Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of histamine secretion by mast cell Source: Ensembl
• positive regulation of potassium ion export across plasma membrane Source: BHF-UCLInferred from direct assayⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
  • "Atrial natriuretic factor blocks the high-threshold Ca2+ current and increases K+ current in fetal single ventricular cells."
    Bkaily G., Perron N., Wang S., Sculptoreanu A., Jacques D., Menard D.
    J. Mol. Cell. Cardiol. 25:1305-1316(1993) [PubMed] [Europe PMC] [Abstract]
• protein folding Source: CAFAInferred from direct assayⁱ
  • Ref.20

    "Structural determinants of natriuretic peptide receptor specificity and degeneracy."
    He X.-L., Dukkipati A., Garcia K.C.
    J. Mol. Biol. 361:698-714(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 129-149 IN COMPLEX WITH NPR3, DISULFIDE BOND.
• receptor guanylyl cyclase signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • Ref.16

    "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
    Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., Goeddel D.V.
    Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of blood pressure Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP)."
    Kangawa K., Matsuo H.
    Biochem. Biophys. Res. Commun. 118:131-139(1984) [PubMed] [Europe PMC] [Abstract]

    Cited for: PROTEIN SEQUENCE OF 124-151.
  • Ref.2

    "mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria."
    Nakayama K., Ohkubo H., Hirose T., Inayama S., Nakanishi S.
    Nature 310:699-701(1984) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
• regulation of blood vessel size Source: UniProtKB-KW
• regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Atrial natriuretic factor blocks the high-threshold Ca2+ current and increases K+ current in fetal single ventricular cells."
    Bkaily G., Perron N., Wang S., Sculptoreanu A., Jacques D., Menard D.
    J. Mol. Cell. Cardiol. 25:1305-1316(1993) [PubMed] [Europe PMC] [Abstract]
• regulation of cardiac conduction Source: Reactome
• regulation of high voltage-gated calcium channel activity Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Atrial natriuretic factor blocks the high-threshold Ca2+ current and increases K+ current in fetal single ventricular cells."
    Bkaily G., Perron N., Wang S., Sculptoreanu A., Jacques D., Menard D.
    J. Mol. Cell. Cardiol. 25:1305-1316(1993) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: Ensembl
• response to insulin Source: Ensembl
• response to muscle stretch Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes."
    Lonardo G., Cerbai E., Casini S., Giunti G., Bonacchi M., Battaglia F., Fiorani B., Stefano P.L., Sani G., Mugelli A.
    Cardiovasc. Res. 63:528-536(2004) [PubMed] [Europe PMC] [Abstract]
• transcription initiation from RNA polymerase II promoter Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• hormone activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• hormone receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.15

    "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
    Bennett B.D., Bennett G.L., Vitangcol R.V., Jewett J.R., Burnier J., Henzel W., Lowe D.G.
    J. Biol. Chem. 266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: RECEPTOR-BINDING.
• neuropeptide hormone activity Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
• neuropeptide receptor binding Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation."
    Abraham R.L., Yang T., Blair M., Roden D.M., Darbar D.
    J. Mol. Cell. Cardiol. 48:181-190(2010) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.16

    "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
    Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., Goeddel D.V.
    Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK 
        60         70         80         90        100
MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG 
       110        120        130        140        150
PWDSSDRSAL LKSKLRALLT APRSLRRSSC FGGRMDRIGA QSGLGCNSFR 

YRR                                                    

Experimental Info

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismⁱ

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
5. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
6. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations