UniProtKB - P01160 (ANF_HUMAN)
Protein
Natriuretic peptides A
Gene
NPPA
Organism
Homo sapiens (Human)
Status
Functioni
Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (PubMed:8653797, PubMed:7595132, PubMed:2825692, PubMed:7720651, PubMed:8087923, PubMed:2532366, PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263, PubMed:16875975). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (PubMed:25401746, PubMed:9893117, PubMed:1672777, PubMed:1660465, PubMed:2162527, PubMed:2825692, PubMed:7720651, PubMed:22307324, PubMed:8384600). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (PubMed:8653797, PubMed:7595132, PubMed:2825692, PubMed:7720651, PubMed:2532366, PubMed:8087923). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (PubMed:16875975). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263). This includes upregulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (PubMed:22307324, PubMed:18835931, PubMed:21672517, PubMed:15741263). Binds the clearance receptor NPR3 which removes the hormone from circulation (PubMed:1672777).By similarity17 Publications
May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis (PubMed:8653797, PubMed:7955907, PubMed:8087923, PubMed:2825692, PubMed:7595132, PubMed:2532366). In vitro, promotes the production of cGMP and induces vasodilation (PubMed:2825692). May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (PubMed:7720651). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator (PubMed:2162527, PubMed:2825692). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (PubMed:11145122).By similarity9 Publications
May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation (PubMed:8653797, PubMed:7955907, PubMed:8087923, PubMed:2532366, PubMed:7595132). In vitro, promotes the production of cGMP and induces vasodilation (PubMed:2825692). May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (PubMed:7720651, PubMed:7595132). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (PubMed:7831500). Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides (PubMed:2162527, PubMed:2825692). Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption (PubMed:11145122).10 Publications
May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis (PubMed:8087923, PubMed:2825692, PubMed:7595132). In vitro, promotes the production of cGMP and induces vasodilation (PubMed:2825692). May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (PubMed:7720651, PubMed:7595132). May have a role in potassium excretion but not sodium excretion (natriuresis) (PubMed:8087923). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (PubMed:11145122).5 Publications
Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis (PubMed:8351194, PubMed:8853410, PubMed:8779891). Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance (PubMed:2528951, PubMed:8351194, PubMed:8853410, PubMed:8779891). Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1 (PubMed:8384600, PubMed:9893117). Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney (PubMed:8779891, PubMed:8384600).6 Publications
May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.By similarity
May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.By similarity
May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.By similarity
May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.By similarity
May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.By similarity
Caution
Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (PubMed:2825692, PubMed:7720651). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).By similarity2 Publications
Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (PubMed:2825692, PubMed:7720651, PubMed:7595132). However, a heterologous expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (PubMed:7831500).4 Publications
GO - Molecular functioni
- hormone activity Source: GO_Central
- hormone receptor binding Source: UniProtKB
- neuropeptide hormone activity Source: BHF-UCL
- neuropeptide receptor binding Source: BHF-UCL
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- cardiac muscle hypertrophy in response to stress Source: Ensembl
- cell growth involved in cardiac muscle cell development Source: Ensembl
- cellular protein metabolic process Source: Reactome
- cellular response to mechanical stimulus Source: Ensembl
- cGMP biosynthetic process Source: GO_Central
- cGMP-mediated signaling Source: GO_Central
- female pregnancy Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of cell growth Source: Ensembl
- negative regulation of collecting lymphatic vessel constriction Source: Ensembl
- negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
- negative regulation of JUN kinase activity Source: UniProtKB
- negative regulation of systemic arterial blood pressure Source: GO_Central
- neuropeptide signaling pathway Source: BHF-UCL
- positive regulation of cardiac muscle contraction Source: BHF-UCL
- positive regulation of cGMP-mediated signaling Source: Ensembl
- positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
- positive regulation of heart rate Source: BHF-UCL
- positive regulation of histamine secretion by mast cell Source: Ensembl
- positive regulation of potassium ion export across plasma membrane Source: BHF-UCL
- protein folding Source: CAFA
- receptor guanylyl cyclase signaling pathway Source: UniProtKB
- regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCL
- regulation of blood pressure Source: UniProtKB
- regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: BHF-UCL
- regulation of cardiac conduction Source: Reactome
- regulation of high voltage-gated calcium channel activity Source: BHF-UCL
- response to hypoxia Source: Ensembl
- response to insulin Source: Ensembl
- response to muscle stretch Source: BHF-UCL
- transcription initiation from RNA polymerase II promoter Source: Reactome
- vasodilation Source: UniProtKB-KW
Keywordsi
Molecular function | Hormone, Vasoactive, Vasodilator |
Enzyme and pathway databases
PathwayCommonsi | P01160 |
Reactomei | R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-5578768, Physiological factors R-HSA-977225, Amyloid fiber formation |
SIGNORi | P01160 |
Names & Taxonomyi
Protein namesi | Recommended name: Natriuretic peptides ACuratedAlternative name(s): Atrial natriuretic factor prohormone1 Publication Short name: proANF1 Publication Atrial natriuretic peptide prohormone1 Publication Short name: preproANP1 Publication Short name: proANPCurated Atriopeptigen1 Publication Cardiodilatin1 Publication Short name: CDD1 Publication preproCDD-ANF1 Publication Cleaved into the following 12 chains: Alternative name(s): Long-acting natriuretic hormoneCurated Short name: LANHCurated Pro atrial natriuretic factor 1-301 Publication Short name: proANF 1-301 Publication Pro atrial natriuretic peptide 1-30Curated Short name: proANP 1-30Curated Alternative name(s): Pro atrial natriuretic factor 31-671 Publication Short name: proANF 31-671 Publication Pro atrial natriuretic peptide 31-67Curated Short name: proANP 31-67Curated Alternative name(s): Pro atrial natriuretic factor 79-981 Publication Short name: proANF 79-981 Publication Pro atrial natriuretic peptide 79-98Curated Short name: proANP 79-98Curated Alternative name(s): CDD 95-1261 Publication CDD-ANP (95-126)1 Publication Pro atrial natriuretic peptide 95-1261 Publication Short name: proANP 95-1261 Publication Auriculin-CCurated Alternative name(s): Atrial natriuretic factor 1-33By similarity Short name: ANF 1-33By similarity Auriculin-DCurated Alternative name(s): Atrial natriuretic factor 3-33By similarity Short name: ANF 3-33By similarity Alternative name(s): Alpha-atrial natriuretic peptide1 Publication Alpha-hANP1 Publication Atrial natriuretic factor1 Publication Short name: ANF1 Publication CDD-ANF1 Publication CDD-ANP (99-126)1 Publication CardionatrinBy similarity Pro atrial natriuretic factor 99-1261 Publication Short name: proANF 99-1261 Publication Auriculin-BCurated Alternative name(s): Atrial natriuretic factor 8-33By similarity Short name: ANF 8-33By similarity Auriculin-ABy similarity Atriopeptin-1By similarity Alternative name(s): Atriopeptin IBy similarity Atriopeptin-2By similarity Alternative name(s): Atriopeptin IIBy similarity Atriopeptin-3By similarity Alternative name(s): Atriopeptin IIIBy similarity |
Gene namesi | Name:NPPA Synonyms:ANP, PND |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175206.10 |
HGNCi | HGNC:7939, NPPA |
MIMi | 108780, gene |
neXtProti | NX_P01160 |
Subcellular locationi
Extracellular region or secreted
- Secreted 4 Publications
Note: Detected in blood.4 Publications
Extracellular region or secreted
- Secreted 4 Publications
Note: Detected in blood.4 Publications
Extracellular region or secreted
- Secreted 1 Publication
Note: Detected in blood.1 Publication
Extracellular region or secreted
- Secreted 6 Publications
Note: Detected in urine (PubMed:2972874, PubMed:9794555, PubMed:8351194, PubMed:8779891). Not detected in blood (PubMed:8351194). Increased electrolytes, osmolality and intracellular cAMP levels increase peptide secretion/excretion (PubMed:9893117, PubMed:8853410, PubMed:8351194, PubMed:8779891).6 Publications
Extracellular region or secreted
- Secreted 10 Publications
Other locations
- Perikaryon 1 Publication
- Cell projection 1 Publication
Note: Detected in blood (PubMed:8351194, PubMed:8779891, PubMed:7955907, PubMed:8653797, PubMed:15741263, PubMed:18835931, PubMed:2532366, PubMed:7984506). Detected in urine in one study (PubMed:8351194). However, in another study, was not detected in urine (PubMed:7984506). Detected in cytoplasmic bodies and neuronal processes of pyramidal neurons (layers II-VI) (PubMed:30534047). Increased secretion in response to the vasopressin AVP (By similarity). Likely to be secreted in response to an increase in atrial pressure or atrial stretch (PubMed:2532366). In kidney cells, secretion increases in response to activated guanylyl cyclases and increased intracellular cAMP levels (PubMed:9893117). Plasma levels increase 15 mins after a high-salt meal, and decrease back to normal plasma levels 1 hr later (PubMed:8779891).By similarity10 Publications
Extracellular region or secreted
- Secreted By similarity
Note: Detected in blood. Slight increase in secretion in response to the vasopressin AVP.By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Lysosome
- mast cell granule Source: Ensembl
Nucleus
- nucleus Source: GO_Central
Other locations
- brush border Source: Ensembl
- cell projection Source: UniProtKB-SubCell
- cytoplasm Source: GO_Central
- perikaryon Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: Ensembl
- protein-containing complex Source: CAFA
Keywords - Cellular componenti
Cell projection, SecretedPathology & Biotechi
Involvement in diseasei
Atrial standstill 2 (ATRST2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071307 | 150 | R → Q in ATRST2. 1 PublicationCorresponds to variant dbSNP:rs202102042EnsemblClinVar. | 1 |
Atrial fibrillation, familial, 6 (ATFB6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 123 | R → G: Loss of cleavage by CORIN. 1 Publication | 1 |
Keywords - Diseasei
Atrial fibrillation, Cardiomyopathy, Disease mutationOrganism-specific databases
DisGeNETi | 4878 |
MalaCardsi | NPPA |
MIMi | 612201, phenotype 615745, phenotype |
OpenTargetsi | ENSG00000175206 |
Orphaneti | 1344, Atrial standstill 334, Familial atrial fibrillation |
PharmGKBi | PA256 |
Miscellaneous databases
Pharosi | P01160, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1293193 |
Polymorphism and mutation databases
BioMutai | NPPA |
DMDMi | 113864 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | By similarityAdd BLAST | 25 | |
ChainiPRO_0000449721 | 26 – 151 | Natriuretic peptides A1 PublicationAdd BLAST | 126 | |
PeptideiPRO_0000449722 | 26 – 55 | Long-acting natriuretic peptide3 PublicationsAdd BLAST | 30 | |
PeptideiPRO_0000449723 | 56 – 92 | Vessel dilator3 PublicationsAdd BLAST | 37 | |
PropeptideiPRO_0000449724 | 93 – 103 | CuratedAdd BLAST | 11 | |
PeptideiPRO_0000449725 | 104 – 123 | Kaliuretic peptide3 PublicationsAdd BLAST | 20 | |
PeptideiPRO_0000449726 | 119 – 151 | Auriculin-CBy similarityAdd BLAST | 33 | |
PeptideiPRO_0000449727 | 120 – 151 | Urodilatin1 PublicationAdd BLAST | 32 | |
PeptideiPRO_0000449728 | 121 – 145 | Auriculin-DBy similarityAdd BLAST | 25 | |
PeptideiPRO_0000449729 | 124 – 151 | Atrial natriuretic peptide5 PublicationsAdd BLAST | 28 | |
PeptideiPRO_0000449730 | 127 – 151 | Auriculin-BBy similarityAdd BLAST | 25 | |
PeptideiPRO_0000449731 | 127 – 150 | Auriculin-ABy similarityAdd BLAST | 24 | |
PeptideiPRO_0000449732 | 128 – 151 | Atriopeptin-3By similarityAdd BLAST | 24 | |
PeptideiPRO_0000449733 | 128 – 150 | Atriopeptin-2By similarityAdd BLAST | 23 | |
PeptideiPRO_0000449734 | 128 – 148 | Atriopeptin-1By similarityAdd BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 129 | Phosphoserine1 Publication | 1 | |
Disulfide bondi | 130 ↔ 146 | 2 Publications |
Post-translational modificationi
The precursor molecule is proteolytically cleaved by CORIN at Arg-123 to produce atrial natriuretic peptide (PubMed:10880574, PubMed:14559895, PubMed:7984506). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (PubMed:2532366, PubMed:7955907, PubMed:7984506). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (PubMed:2972874, PubMed:8351194, PubMed:9794555).By similarity8 Publications
Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulates its activity.1 Publication
Phosphorylation on Ser-129 decreases vasorelaxant activity.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 123 – 124 | Cleavage; by CORIN1 Publication | 2 | |
Sitei | 130 – 131 | Cleavage; by MME1 Publication | 2 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
MassIVEi | P01160 |
PaxDbi | P01160 |
PeptideAtlasi | P01160 |
PRIDEi | P01160 |
ProteomicsDBi | 51340 |
PTM databases
CarbonylDBi | P01160 |
GlyGeni | P01160, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P01160 |
PhosphoSitePlusi | P01160 |
Expressioni
Tissue specificityi
Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555, PubMed:8384600). Present in urine (at protein level) (PubMed:2972874, PubMed:9794555, PubMed:8351194, PubMed:8779891).5 Publications
Detected in atrial and ventricular plasma samples, and in adipocytes (at protein level) (PubMed:22291141, PubMed:21672517). Detected in urine in one study (PubMed:8351194). However, was not detected in urine in another study (PubMed:7984506). In the brain, predominantly expressed in the gray matter with very weak expression in the white matter (at protein level) (PubMed:30534047). Localizes to astrocyte-like structures throughout the white matter, and in the cerebral vessels detected in the leptomeningeal and parenchymal vessels, and endothelium and smooth muscle layers (at protein level) (PubMed:30534047). Relatively low levels of expression in the kidneys compared to urodilatin (at protein level) (PubMed:9794555, PubMed:8384600).7 Publications
Gene expression databases
Bgeei | ENSG00000175206, Expressed in cardiac muscle of right atrium and 203 other tissues |
ExpressionAtlasi | P01160, baseline and differential |
Genevisiblei | P01160, HS |
Organism-specific databases
HPAi | ENSG00000175206, Tissue enriched (heart) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP01160
With | #Exp. | IntAct |
---|---|---|
HSF2BP [O75031] | 3 | EBI-953859,EBI-7116203 |
MAGEA12 [P43365] | 6 | EBI-953859,EBI-749530 |
UBQLN1 [Q9UMX0] | 3 | EBI-953859,EBI-741480 |
UBQLN2 [Q9UHD9] | 3 | EBI-953859,EBI-947187 |
GO - Molecular functioni
- hormone activity Source: GO_Central
- hormone receptor binding Source: UniProtKB
- neuropeptide hormone activity Source: BHF-UCL
- neuropeptide receptor binding Source: BHF-UCL
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110938, 52 interactors |
IntActi | P01160, 39 interactors |
STRINGi | 9606.ENSP00000365663 |
Miscellaneous databases
RNActi | P01160, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P01160 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01160 |
Family & Domainsi
Sequence similaritiesi
Belongs to the natriuretic peptide family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S9RQ, Eukaryota |
GeneTreei | ENSGT00940000154513 |
InParanoidi | P01160 |
OMAi | LSEVPPW |
OrthoDBi | 1596502at2759 |
PhylomeDBi | P01160 |
TreeFami | TF106304 |
Family and domain databases
DisProti | DP00747 |
InterProi | View protein in InterPro IPR000663, Natr_peptide IPR030480, Natr_peptide_CS IPR002407, Natriuretic_peptide_atrial |
Pfami | View protein in Pfam PF00212, ANP, 1 hit |
PRINTSi | PR00711, ANATPEPTIDE PR00710, NATPEPTIDES |
SMARTi | View protein in SMART SM00183, NAT_PEP, 1 hit |
PROSITEi | View protein in PROSITE PS00263, NATRIURETIC_PEPTIDE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P01160-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK
60 70 80 90 100
MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG
110 120 130 140 150
PWDSSDRSAL LKSKLRALLT APRSLRRSSC FGGRMDRIGA QSGLGCNSFR
Y
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X094 | A0A087X094_HUMAN | Atrial natriuretic factor | NPPA | 152 | Annotation score: | ||
B0ZBE8 | B0ZBE8_HUMAN | Atrial natriuretic factor | NPPA | 101 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | E → D in AAA35529 (PubMed:3158606).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014579 | 32 | V → M. Corresponds to variant dbSNP:rs5063Ensembl. | 1 | |
Natural variantiVAR_071307 | 150 | R → Q in ATRST2. 1 PublicationCorresponds to variant dbSNP:rs202102042EnsemblClinVar. | 1 | |
Natural variantiVAR_082651 | 151 | Y → YRR2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02043 Genomic DNA Translation: AAB59379.1 M30262 mRNA Translation: AAA35669.1 X01470, X02558 Genomic DNA Translation: CAA25699.1 X01471 Genomic DNA Translation: CAA25700.2 M54951, M54947 Genomic DNA Translation: AAA35529.1 AL021155 Genomic DNA No translation available. EU326308 Genomic DNA Translation: ACA05916.1 BC005893 mRNA Translation: AAH05893.1 K02399 Genomic DNA Translation: AAA35528.1 K02044 mRNA Translation: AAA51730.1 |
CCDSi | CCDS139.1 |
PIRi | A22693, AWHU |
RefSeqi | NP_006163.1, NM_006172.3 |
Genome annotation databases
Ensembli | ENST00000376480; ENSP00000365663; ENSG00000175206 |
GeneIDi | 4878 |
KEGGi | hsa:4878 |
UCSCi | uc001ati.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Atrial natriuretic peptide entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02043 Genomic DNA Translation: AAB59379.1 M30262 mRNA Translation: AAA35669.1 X01470, X02558 Genomic DNA Translation: CAA25699.1 X01471 Genomic DNA Translation: CAA25700.2 M54951, M54947 Genomic DNA Translation: AAA35529.1 AL021155 Genomic DNA No translation available. EU326308 Genomic DNA Translation: ACA05916.1 BC005893 mRNA Translation: AAH05893.1 K02399 Genomic DNA Translation: AAA35528.1 K02044 mRNA Translation: AAA51730.1 |
CCDSi | CCDS139.1 |
PIRi | A22693, AWHU |
RefSeqi | NP_006163.1, NM_006172.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ANP | NMR | - | A | 124-151 | [»] | |
1YK0 | X-ray | 2.40 | E | 129-149 | [»] | |
3N57 | X-ray | 3.03 | C/D | 124-151 | [»] | |
SMRi | P01160 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110938, 52 interactors |
IntActi | P01160, 39 interactors |
STRINGi | 9606.ENSP00000365663 |
Chemistry databases
ChEMBLi | CHEMBL1293193 |
PTM databases
CarbonylDBi | P01160 |
GlyGeni | P01160, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P01160 |
PhosphoSitePlusi | P01160 |
Polymorphism and mutation databases
BioMutai | NPPA |
DMDMi | 113864 |
Proteomic databases
MassIVEi | P01160 |
PaxDbi | P01160 |
PeptideAtlasi | P01160 |
PRIDEi | P01160 |
ProteomicsDBi | 51340 |
Protocols and materials databases
Antibodypediai | 13911, 727 antibodies |
DNASUi | 4878 |
Genome annotation databases
Ensembli | ENST00000376480; ENSP00000365663; ENSG00000175206 |
GeneIDi | 4878 |
KEGGi | hsa:4878 |
UCSCi | uc001ati.4, human |
Organism-specific databases
CTDi | 4878 |
DisGeNETi | 4878 |
EuPathDBi | HostDB:ENSG00000175206.10 |
GeneCardsi | NPPA |
HGNCi | HGNC:7939, NPPA |
HPAi | ENSG00000175206, Tissue enriched (heart) |
MalaCardsi | NPPA |
MIMi | 108780, gene 612201, phenotype 615745, phenotype |
neXtProti | NX_P01160 |
OpenTargetsi | ENSG00000175206 |
Orphaneti | 1344, Atrial standstill 334, Familial atrial fibrillation |
PharmGKBi | PA256 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9RQ, Eukaryota |
GeneTreei | ENSGT00940000154513 |
InParanoidi | P01160 |
OMAi | LSEVPPW |
OrthoDBi | 1596502at2759 |
PhylomeDBi | P01160 |
TreeFami | TF106304 |
Enzyme and pathway databases
PathwayCommonsi | P01160 |
Reactomei | R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-5578768, Physiological factors R-HSA-977225, Amyloid fiber formation |
SIGNORi | P01160 |
Miscellaneous databases
BioGRID-ORCSi | 4878, 5 hits in 841 CRISPR screens |
EvolutionaryTracei | P01160 |
GeneWikii | Atrial_natriuretic_peptide |
GenomeRNAii | 4878 |
Pharosi | P01160, Tchem |
PROi | PR:P01160 |
RNActi | P01160, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175206, Expressed in cardiac muscle of right atrium and 203 other tissues |
ExpressionAtlasi | P01160, baseline and differential |
Genevisiblei | P01160, HS |
Family and domain databases
DisProti | DP00747 |
InterProi | View protein in InterPro IPR000663, Natr_peptide IPR030480, Natr_peptide_CS IPR002407, Natriuretic_peptide_atrial |
Pfami | View protein in Pfam PF00212, ANP, 1 hit |
PRINTSi | PR00711, ANATPEPTIDE PR00710, NATPEPTIDES |
SMARTi | View protein in SMART SM00183, NAT_PEP, 1 hit |
PROSITEi | View protein in PROSITE PS00263, NATRIURETIC_PEPTIDE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANF_HUMAN | |
Accessioni | P01160Primary (citable) accession number: P01160 Secondary accession number(s): Q13766, Q5JZE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 211 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations