NPPA

Functionⁱ

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.1 Publication

GO - Molecular functionⁱ

hormone receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 1660465
neuropeptide hormone activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19646991
neuropeptide receptor binding
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19646991
signaling receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1672777

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac muscle hypertrophy in response to stress Source: Ensembl
cell growth involved in cardiac muscle cell development Source: Ensembl
cellular protein metabolic process Source: Reactome
cellular response to mechanical stimulus Source: Ensembl
cGMP biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 1672777
cGMP-mediated signaling Source: Ensembl
female pregnancy Source: UniProtKB
negative regulation of cell growth Source: Ensembl
negative regulation of collecting lymphatic vessel constriction Source: Ensembl
negative regulation of systemic arterial blood pressure Source: Ensembl
neuropeptide signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 19646991
positive regulation of cardiac muscle contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19646991
positive regulation of cGMP-mediated signaling Source: Ensembl
positive regulation of delayed rectifier potassium channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19646991
- 8301666
positive regulation of heart rate
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19646991
positive regulation of histamine secretion by mast cell Source: Ensembl
positive regulation of potassium ion export across plasma membrane
Source: BHF-UCL
Inferred from direct assayⁱ
- 19646991
- 8301666
protein folding
Source: CAFA
Inferred from direct assayⁱ
- 16870210
receptor guanylyl cyclase signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 1672777
regulation of atrial cardiac muscle cell membrane repolarization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19646991
regulation of blood pressure
Source: UniProtKB
Inferred from direct assayⁱ
- 6230082
- 6547996
regulation of blood vessel size Source: UniProtKB-KW
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 8301666
regulation of cardiac conduction Source: Reactome
regulation of high voltage-gated calcium channel activity
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 8301666
response to hypoxia Source: Ensembl
response to insulin Source: Ensembl
response to muscle stretch
Source: BHF-UCL
Traceable author statementⁱ
- 15276478
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone, Vasoactive

Molecular function

Hormone, Vasoactive

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-5578768 Physiological factors R-HSA-977225 Amyloid fiber formation
SIGNORⁱ	P01160

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Natriuretic peptides A Alternative name(s): CDD-ANF Cardiodilatin Short name: CDD Cardiodilatin-related peptide Short name: CDP Prepronatriodilatin Cleaved into the following chain: Atrial natriuretic factor Short name: ANF Alternative name(s): Atrial natriuretic peptide Short name: ANP
Gene namesⁱ	Name:NPPA Synonyms:ANP, PND
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175206.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7939 NPPA
MIMⁱ	108780 gene
neXtProtⁱ	NX_P01160

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Atrial standstill 2 (ATRST2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071307	150	R → Q in ATRST2. 1 Publication		1

Atrial fibrillation, familial, 6 (ATFB6)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	123	R → G: Loss of cleavage by CORIN. 1 Publication		1

Keywords - Diseaseⁱ

Atrial fibrillation, Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4878
MalaCards human disease database More...MalaCardsⁱ	NPPA
MIMⁱ	612201 phenotype 615745 phenotype
Orphanetⁱ	1344 Atrial standstill 334 Familial atrial fibrillation
PharmGKBⁱ	PA256

Chemistry databases

ChEMBLⁱ	CHEMBL1293193

ChEMBLⁱ

CHEMBL1293193

Polymorphism and mutation databases

BioMutaⁱ	NPPA
DMDMⁱ	113864

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 25	By similarityAdd BLAST	25
PropeptideⁱPRO_0000001493	26 – 123	CuratedAdd BLAST	98
PeptideⁱPRO_0000001494	124 – 151	Atrial natriuretic factor2 PublicationsAdd BLAST	28

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	130 ↔ 146	1 Publication

Post-translational modificationⁱ

Cleaved by CORIN upon secretion to produce the functional hormone.2 Publications

Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	123 – 124	Cleavage; by CORIN1 Publication		2
Siteⁱ	130 – 131	Cleavage; by MME1 Publication		2

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	P01160
PeptideAtlas More...PeptideAtlasⁱ	P01160
PRIDEⁱ	P01160
ProteomicsDBⁱ	51340

PTM databases

CarbonylDBⁱ	P01160
iPTMnetⁱ	P01160
PhosphoSitePlusⁱ	P01160

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000175206 Expressed in 188 organ(s), highest expression level in cardiac muscle of right atrium
CleanExⁱ	HS_NPPA
ExpressionAtlasⁱ	P01160 baseline and differential
Genevisibleⁱ	P01160 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058269

HPAⁱ

HPA058269

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MAGEA12	P43365	5	EBI-953859,EBI-749530
UBQLN1	Q9UMX0	3	EBI-953859,EBI-741480

GO - Molecular functionⁱ

hormone receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 1660465
neuropeptide hormone activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19646991
neuropeptide receptor binding
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19646991
signaling receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1672777

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110938, 50 interactors
IntActⁱ	P01160, 5 interactors
STRINGⁱ	9606.ENSP00000365663

Chemistry databases

BindingDBⁱ

P01160

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	139 – 141	Combined sources		3

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00747
ProteinModelPortalⁱ	P01160
SMRⁱ	P01160
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P01160

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the natriuretic peptide family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IW5F Eukaryota ENOG410ZUY6 LUCA
HOGENOMⁱ	HOG000033937
HOVERGENⁱ	HBG004227
InParanoidⁱ	P01160
KEGG Orthology (KO) More...KOⁱ	K12334
PhylomeDBⁱ	P01160
TreeFamⁱ	TF106304

Family and domain databases

InterProⁱ	View protein in InterPro IPR000663 Natr_peptide IPR030480 Natr_peptide_CS IPR002407 Natriuretic_peptide_atrial
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00212 ANP, 1 hit
PRINTSⁱ	PR00711 ANATPEPTIDE PR00710 NATPEPTIDES
SMARTⁱ	View protein in SMART SM00183 NAT_PEP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P01160-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK 
        60         70         80         90        100
MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG 
       110        120        130        140        150
PWDSSDRSAL LKSKLRALLT APRSLRRSSC FGGRMDRIGA QSGLGCNSFR 

YRR

Length:153

Mass (Da):16,708

Last modified:August 13, 1987 - v1

Checksum:ⁱB38F03AA066A73EC

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X094	A0A087X094_HUMAN	Natriuretic peptides A Natriuretic peptides A	NPPA	152	Annotation score:
B0ZBE8	B0ZBE8_HUMAN	Natriuretic peptide A variant 1 Natriuretic peptide A variant 1 (Natriuretic peptides A)	NPPA	101	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	65	E → D in AAA35529 (PubMed:3158606).Curated		1

Polymorphismⁱ

There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014579	32	V → M. Corresponds to variant dbSNP:rs5063Ensembl.	1
Natural variantⁱVAR_071307	150	R → Q in ATRST2. 1 Publication	1
Natural variantⁱVAR_000594	152 – 153	Missing in allele 2.	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K02043 Genomic DNA Translation: AAB59379.1 M30262 mRNA Translation: AAA35669.1 X01470, X02558 Genomic DNA Translation: CAA25699.1 X01471 Genomic DNA Translation: CAA25700.2 M54951, M54947 Genomic DNA Translation: AAA35529.1 AL021155 Genomic DNA No translation available. EU326308 Genomic DNA Translation: ACA05916.1 BC005893 mRNA Translation: AAH05893.1 K02399 Genomic DNA Translation: AAA35528.1 K02044 mRNA Translation: AAA51730.1
PIRⁱ	A22693 AWHU
NCBI Reference Sequences More...RefSeqⁱ	NP_006163.1, NM_006172.3
UniGeneⁱ	Hs.75640

Genome annotation databases

Ensemblⁱ	ENST00000376480; ENSP00000365663; ENSG00000175206
GeneIDⁱ	4878
KEGGⁱ	hsa:4878
UCSC genome browser More...UCSCⁱ	uc001ati.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01160	NPPA isoform 2		PANTR		153	UniRef100_P01160
Natriuretic peptides A		HUMAN		152
Atrial natriuretic peptide (Fragment)		CANLF		77
NPPA isoform 3 (Fragment)		PANTR		152
Natriuretic peptide A variant 1		HUMAN		101
+3

Protein	Similar proteins		Species	Score	Length	Source
P01160	NPPA isoform 2		PANTR		153	UniRef90_P01160
Natriuretic peptides A		HUMAN		152
Atrial natriuretic peptide (Fragment)		CANLF		77
Uncharacterized protein		AOTNA		161
Natriuretic peptide A		SAIBB		153
+26

Protein	Similar proteins		Species	Score	Length	Source
P01160	Natriuretic peptides A		HORSE		153	UniRef50_P01160
Natriuretic peptides A	)	RAT		152
Natriuretic peptides A		RABIT		153
Natriuretic peptides A		MOUSE		152
Natriuretic peptides A (Fragment)		CAVPO		128
+86

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Atrial natriuretic peptide entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K02043 Genomic DNA Translation: AAB59379.1 M30262 mRNA Translation: AAA35669.1 X01470, X02558 Genomic DNA Translation: CAA25699.1 X01471 Genomic DNA Translation: CAA25700.2 M54951, M54947 Genomic DNA Translation: AAA35529.1 AL021155 Genomic DNA No translation available. EU326308 Genomic DNA Translation: ACA05916.1 BC005893 mRNA Translation: AAH05893.1 K02399 Genomic DNA Translation: AAA35528.1 K02044 mRNA Translation: AAA51730.1
PIRⁱ	A22693 AWHU
RefSeqⁱ	NP_006163.1, NM_006172.3
UniGeneⁱ	Hs.75640

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ANP	NMR	-	A	124-151	[»]
	1YK0	X-ray	2.40	E	129-149	[»]
	3N57	X-ray	3.03	C/D	124-151	[»]
DisProtⁱ	DP00747
ProteinModelPortalⁱ	P01160
SMRⁱ	P01160
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110938, 50 interactors
IntActⁱ	P01160, 5 interactors
STRINGⁱ	9606.ENSP00000365663

Chemistry databases

BindingDBⁱ	P01160
ChEMBLⁱ	CHEMBL1293193

PTM databases

CarbonylDBⁱ	P01160
iPTMnetⁱ	P01160
PhosphoSitePlusⁱ	P01160

Polymorphism and mutation databases

BioMutaⁱ	NPPA
DMDMⁱ	113864

Proteomic databases

PaxDbⁱ	P01160
PeptideAtlasⁱ	P01160
PRIDEⁱ	P01160
ProteomicsDBⁱ	51340

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4878
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000376480; ENSP00000365663; ENSG00000175206
GeneIDⁱ	4878
KEGGⁱ	hsa:4878
UCSCⁱ	uc001ati.4 human

Organism-specific databases

CTDⁱ	4878
DisGeNETⁱ	4878
EuPathDBⁱ	HostDB:ENSG00000175206.10
GeneCardsⁱ	NPPA
H-InvDBⁱ	HIX0199955
HGNCⁱ	HGNC:7939 NPPA
HPAⁱ	HPA058269
MalaCardsⁱ	NPPA
MIMⁱ	108780 gene 612201 phenotype 615745 phenotype
neXtProtⁱ	NX_P01160
Orphanetⁱ	1344 Atrial standstill 334 Familial atrial fibrillation
PharmGKBⁱ	PA256
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IW5F Eukaryota ENOG410ZUY6 LUCA
HOGENOMⁱ	HOG000033937
HOVERGENⁱ	HBG004227
InParanoidⁱ	P01160
KOⁱ	K12334
PhylomeDBⁱ	P01160
TreeFamⁱ	TF106304

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-5578768 Physiological factors R-HSA-977225 Amyloid fiber formation
SIGNORⁱ	P01160

Miscellaneous databases

EvolutionaryTraceⁱ	P01160
GeneWikiⁱ	Atrial_natriuretic_peptide
GenomeRNAiⁱ	4878
Protein Ontology More...PROⁱ	PR:P01160
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175206 Expressed in 188 organ(s), highest expression level in cardiac muscle of right atrium
CleanExⁱ	HS_NPPA
ExpressionAtlasⁱ	P01160 baseline and differential
Genevisibleⁱ	P01160 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000663 Natr_peptide IPR030480 Natr_peptide_CS IPR002407 Natriuretic_peptide_atrial
Pfamⁱ	View protein in Pfam PF00212 ANP, 1 hit
PRINTSⁱ	PR00711 ANATPEPTIDE PR00710 NATPEPTIDES
SMARTⁱ	View protein in SMART SM00183 NAT_PEP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00263 NATRIURETIC_PEPTIDE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANF_HUMAN
Accessionⁱ	P01160Primary (citable) accession number: P01160 Secondary accession number(s): Q13766, Q5JZE1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	August 13, 1987
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P01160 (ANF_HUMAN)

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Natriuretic peptides A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Lysosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ