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Protein

Beta-nerve growth factor

Gene

Ngf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.By similarity

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • metalloendopeptidase inhibitor activity Source: UniProtKB
  • nerve growth factor receptor binding Source: MGI
  • transmembrane receptor protein tyrosine kinase activator activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-167060 NGF processing
R-MMU-170968 Frs2-mediated activation
R-MMU-170984 ARMS-mediated activation
R-MMU-177504 Retrograde neurotrophin signalling
R-MMU-187042 TRKA activation by NGF
R-MMU-198203 PI3K/AKT activation
R-MMU-205017 NFG and proNGF binds to p75NTR
R-MMU-205025 NADE modulates death signalling
R-MMU-205043 NRIF signals cell death from the nucleus
R-MMU-209543 p75NTR recruits signalling complexes
R-MMU-209560 NF-kB is activated and signals survival
R-MMU-209563 Axonal growth stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-nerve growth factor
Short name:
Beta-NGF
Gene namesi
Name:Ngf
Synonyms:Ngfb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:97321 Ngf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001960119 – 1211 PublicationAdd BLAST103
ChainiPRO_0000019602122 – 241Beta-nerve growth factorAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 201
Disulfide bondi179 ↔ 229
Disulfide bondi189 ↔ 231

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01139
PaxDbiP01139
PeptideAtlasiP01139
PRIDEiP01139

PTM databases

PhosphoSitePlusiP01139

Expressioni

Inductioni

Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000027859 Expressed in 62 organ(s), highest expression level in submandibular gland
CleanExiMM_NGF
ExpressionAtlasiP01139 baseline and differential
GenevisibleiP01139 MM

Interactioni

Subunit structurei

Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201764, 1 interactor
DIPiDIP-59840N
IntActiP01139, 4 interactors
STRINGi10090.ENSMUSP00000102538

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00836
ProteinModelPortaliP01139
SMRiP01139
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01139

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIPQ Eukaryota
ENOG4111F87 LUCA
GeneTreeiENSGT00390000007725
HOVERGENiHBG006494
InParanoidiP01139
KOiK02582
PhylomeDBiP01139

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR020425 Nerve_growth_factor_bsu
IPR020437 Nerve_growth_factor_bsu_mml
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01925 MAMLNGFBETA
PR00268 NGF
PR01913 NGFBETA
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P01139-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMLFYTLIT AFLIGVQAEP YTDSNVPEGD SVPEAHWTKL QHSLDTALRR
60 70 80 90 100
ARSAPTAPIA ARVTGQTRNI TVDPRLFKKR RLHSPRVLFS TQPPPTSSDT
110 120 130 140 150
LDLDFQAHGT IPFNRTHRSK RSSTHPVFHM GEFSVCDSVS VWVGDKTTAT
160 170 180 190 200
DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY
210 220 230 240
CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G
Length:241
Mass (Da):27,077
Last modified:January 1, 1990 - v2
Checksum:i164465E1DC550081
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6LDU8Q6LDU8_MOUSE
Beta-nerve growth factor
Ngf NGF, Ngfb, mCG_5471
307Annotation score:
A0A0G2JEK0A0A0G2JEK0_MOUSE
Beta-nerve growth factor
Ngf
303Annotation score:
A0A0G2JG51A0A0G2JG51_MOUSE
Beta-nerve growth factor
Ngf
22Annotation score:

Sequence cautioni

The sequence AAA37687 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA39818 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA39820 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA39821 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA24221 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233 – 241LSRKATRRG → CSAGRLQEEADLPAAPFPTC PLHTLLGPSLPQPVNYFKL in AAB26820 (PubMed:1284621).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35075 mRNA Translation: AAA39818.1 Different initiation.
V00836 mRNA Translation: CAA24221.1 Different initiation.
K01759 mRNA Translation: AAA39820.1 Different initiation.
M14805 mRNA Translation: AAA39821.1 Different initiation.
M17298, M17296, M17297 Genomic DNA Translation: AAA37687.1 Different initiation.
S62089 mRNA Translation: AAB26820.2
CCDSiCCDS51025.1
RefSeqiNP_001106168.1, NM_001112698.2
NP_038637.1, NM_013609.3
XP_006501171.1, XM_006501108.3
UniGeneiMm.1259

Genome annotation databases

EnsembliENSMUST00000035952; ENSMUSP00000040345; ENSMUSG00000027859
GeneIDi18049
KEGGimmu:18049
UCSCiuc012cuz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35075 mRNA Translation: AAA39818.1 Different initiation.
V00836 mRNA Translation: CAA24221.1 Different initiation.
K01759 mRNA Translation: AAA39820.1 Different initiation.
M14805 mRNA Translation: AAA39821.1 Different initiation.
M17298, M17296, M17297 Genomic DNA Translation: AAA37687.1 Different initiation.
S62089 mRNA Translation: AAB26820.2
CCDSiCCDS51025.1
RefSeqiNP_001106168.1, NM_001112698.2
NP_038637.1, NM_013609.3
XP_006501171.1, XM_006501108.3
UniGeneiMm.1259

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BETX-ray2.30A131-237[»]
1BTGX-ray2.50A/B/C130-239[»]
1SGFX-ray3.15B/Y122-239[»]
3IJ2X-ray3.75A/B19-241[»]
4EAXX-ray2.30A/B/C/D122-241[»]
4XPJX-ray2.60A/B122-241[»]
5LSDNMR-A/B122-239[»]
6FFYX-ray3.90B/C122-238[»]
DisProtiDP00836
ProteinModelPortaliP01139
SMRiP01139
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201764, 1 interactor
DIPiDIP-59840N
IntActiP01139, 4 interactors
STRINGi10090.ENSMUSP00000102538

PTM databases

PhosphoSitePlusiP01139

Proteomic databases

MaxQBiP01139
PaxDbiP01139
PeptideAtlasiP01139
PRIDEiP01139

Protocols and materials databases

DNASUi18049
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035952; ENSMUSP00000040345; ENSMUSG00000027859
GeneIDi18049
KEGGimmu:18049
UCSCiuc012cuz.2 mouse

Organism-specific databases

CTDi4803
MGIiMGI:97321 Ngf

Phylogenomic databases

eggNOGiENOG410IIPQ Eukaryota
ENOG4111F87 LUCA
GeneTreeiENSGT00390000007725
HOVERGENiHBG006494
InParanoidiP01139
KOiK02582
PhylomeDBiP01139

Enzyme and pathway databases

ReactomeiR-MMU-167060 NGF processing
R-MMU-170968 Frs2-mediated activation
R-MMU-170984 ARMS-mediated activation
R-MMU-177504 Retrograde neurotrophin signalling
R-MMU-187042 TRKA activation by NGF
R-MMU-198203 PI3K/AKT activation
R-MMU-205017 NFG and proNGF binds to p75NTR
R-MMU-205025 NADE modulates death signalling
R-MMU-205043 NRIF signals cell death from the nucleus
R-MMU-209543 p75NTR recruits signalling complexes
R-MMU-209560 NF-kB is activated and signals survival
R-MMU-209563 Axonal growth stimulation

Miscellaneous databases

EvolutionaryTraceiP01139
PROiPR:P01139
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027859 Expressed in 62 organ(s), highest expression level in submandibular gland
CleanExiMM_NGF
ExpressionAtlasiP01139 baseline and differential
GenevisibleiP01139 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR020425 Nerve_growth_factor_bsu
IPR020437 Nerve_growth_factor_bsu_mml
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01925 MAMLNGFBETA
PR00268 NGF
PR01913 NGFBETA
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNGF_MOUSE
AccessioniPrimary (citable) accession number: P01139
Secondary accession number(s): Q63864, Q6LDB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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