Ngf

Functionⁱ

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.By similarity

GO - Molecular functionⁱ

growth factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metalloendopeptidase inhibitor activity Source: UniProtKB
nerve growth factor receptor binding Source: MGI
transmembrane receptor protein tyrosine kinase activator activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19036963

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior Source: MGI
circadian rhythm
Source: UniProtKB
Inferred from expression patternⁱ
- 23785138
extrinsic apoptotic signaling pathway in absence of ligand
Source: MGI
Inferred from direct assayⁱ
- 14623868
extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
memory Source: MGI
modulation of chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of neuron apoptotic process
Source: MGI
Inferred from genetic interactionⁱ
- 11731452
- 24270184
negative regulation of type B pancreatic cell apoptotic process Source: MGI
nerve development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nerve growth factor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 7854358
neuron apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 14623868
neuron development
Source: MGI
Inferred from direct assayⁱ
- 27655914
neuron projection development
Source: MGI
Inferred from direct assayⁱ
- 27655914
neuron projection morphogenesis
Source: MGI
Inferred from sequence orthologyⁱ
- 17724343
peripheral nervous system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 14736860
positive regulation of axon extension
Source: MGI
Inferred from direct assayⁱ
- 18052984
positive regulation of cell growth Source: MGI
positive regulation of cell proliferation Source: MGI
positive regulation of collateral sprouting
Source: MGI
Inferred from direct assayⁱ
- 18052984
positive regulation of DNA binding
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 10362258
positive regulation of DNA-binding transcription factor activity
Source: MGI
Inferred from sequence orthologyⁱ
- 19029245
positive regulation of gene expression
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 10362258
positive regulation of neuron differentiation Source: MGI
positive regulation of neuron maturation
Source: MGI
Inferred from direct assayⁱ
- 23015435
positive regulation of neuron projection development
Source: MGI
Inferred from direct assayⁱ
- 23015435
positive regulation of neurotrophin TRK receptor signaling pathway
Source: MGI
Inferred from sequence orthologyⁱ
- 19029245
positive regulation of protein autophosphorylation
Source: MGI
Inferred from sequence orthologyⁱ
- 19029245
positive regulation of protein binding Source: MGI
positive regulation of protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19036963
positive regulation of protein ubiquitination
Source: MGI
Inferred from direct assayⁱ
- 24760869
positive regulation of Ras protein signal transduction
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 11877426
positive regulation of stem cell proliferation Source: MGI
regulation of neuron differentiation
Source: MGI
Inferred from direct assayⁱ
- 16516892
regulation of neurotransmitter secretion
Source: MGI
Inferred from genetic interactionⁱ
- 16298082
regulation of release of sequestered calcium ion into cytosol
Source: MGI
Inferred from genetic interactionⁱ
- 24265601
sensory perception of pain
Source: MGI
Inferred from mutant phenotypeⁱ
- 8137419
transmembrane receptor protein tyrosine kinase signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Molecular function

Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-167060 NGF processing R-MMU-170968 Frs2-mediated activation R-MMU-170984 ARMS-mediated activation R-MMU-177504 Retrograde neurotrophin signalling R-MMU-187042 TRKA activation by NGF R-MMU-198203 PI3K/AKT activation R-MMU-205017 NFG and proNGF binds to p75NTR R-MMU-205025 NADE modulates death signalling R-MMU-205043 NRIF signals cell death from the nucleus R-MMU-209543 p75NTR recruits signalling complexes R-MMU-209560 NF-kB is activated and signals survival R-MMU-209563 Axonal growth stimulation

Reactomeⁱ

R-MMU-167060 NGF processing
R-MMU-170968 Frs2-mediated activation
R-MMU-170984 ARMS-mediated activation
R-MMU-177504 Retrograde neurotrophin signalling
R-MMU-187042 TRKA activation by NGF
R-MMU-198203 PI3K/AKT activation
R-MMU-205017 NFG and proNGF binds to p75NTR
R-MMU-205025 NADE modulates death signalling
R-MMU-205043 NRIF signals cell death from the nucleus
R-MMU-209543 p75NTR recruits signalling complexes
R-MMU-209560 NF-kB is activated and signals survival
R-MMU-209563 Axonal growth stimulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-nerve growth factor Short name: Beta-NGF
Gene namesⁱ	Name:Ngf Synonyms:Ngfb
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:97321 Ngf

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST	18
PropeptideⁱPRO_0000019601	19 – 121	1 PublicationAdd BLAST	103
ChainⁱPRO_0000019602	122 – 241	Beta-nerve growth factorAdd BLAST	120

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	69	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	136 ↔ 201
Disulfide bondⁱ	179 ↔ 229
Disulfide bondⁱ	189 ↔ 231

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01139
PaxDbⁱ	P01139
PeptideAtlas More...PeptideAtlasⁱ	P01139
PRIDEⁱ	P01139

PTM databases

PhosphoSitePlusⁱ	P01139

PhosphoSitePlusⁱ

P01139

Expressionⁱ

Inductionⁱ

Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000027859 Expressed in 62 organ(s), highest expression level in submandibular gland
CleanExⁱ	MM_NGF
ExpressionAtlasⁱ	P01139 baseline and differential
Genevisibleⁱ	P01139 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.By similarity

GO - Molecular functionⁱ

growth factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nerve growth factor receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201764, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-59840N
IntActⁱ	P01139, 4 interactors
STRINGⁱ	10090.ENSMUSP00000102538

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	127 – 130	Combined sources	4
Beta strandⁱ	133 – 136	Combined sources	4
Beta strandⁱ	138 – 144	Combined sources	7
Beta strandⁱ	148 – 151	Combined sources	4
Beta strandⁱ	156 – 159	Combined sources	4
Beta strandⁱ	161 – 165	Combined sources	5
Beta strandⁱ	168 – 171	Combined sources	4
Beta strandⁱ	174 – 180	Combined sources	7
Turnⁱ	194 – 196	Combined sources	3
Beta strandⁱ	197 – 213	Combined sources	17
Beta strandⁱ	218 – 235	Combined sources	18

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00836
ProteinModelPortalⁱ	P01139
SMRⁱ	P01139
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P01139

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NGF-beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IIPQ Eukaryota ENOG4111F87 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007725
HOVERGENⁱ	HBG006494
InParanoidⁱ	P01139
KEGG Orthology (KO) More...KOⁱ	K02582
PhylomeDBⁱ	P01139

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020408 Nerve_growth_factor-like IPR002072 Nerve_growth_factor-rel IPR020425 Nerve_growth_factor_bsu IPR020437 Nerve_growth_factor_bsu_mml IPR019846 Nerve_growth_factor_CS
PANTHERⁱ	PTHR11589 PTHR11589, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00243 NGF, 1 hit
PIRSFⁱ	PIRSF001789 NGF, 1 hit
PRINTSⁱ	PR01925 MAMLNGFBETA PR00268 NGF PR01913 NGFBETA
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002052 Nerve_growth_factor-rel, 1 hit
SMARTⁱ	View protein in SMART SM00140 NGF, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00248 NGF_1, 1 hit PS50270 NGF_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P01139-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSMLFYTLIT AFLIGVQAEP YTDSNVPEGD SVPEAHWTKL QHSLDTALRR 
        60         70         80         90        100
ARSAPTAPIA ARVTGQTRNI TVDPRLFKKR RLHSPRVLFS TQPPPTSSDT 
       110        120        130        140        150
LDLDFQAHGT IPFNRTHRSK RSSTHPVFHM GEFSVCDSVS VWVGDKTTAT 
       160        170        180        190        200
DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY 
       210        220        230        240 
CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G

Length:241

Mass (Da):27,077

Last modified:January 1, 1990 - v2

Checksum:ⁱ164465E1DC550081

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q6LDU8	Q6LDU8_MOUSE	Beta-nerve growth factor Beta-nerve growth factor (Nerve growth factor) (Nerve growth factor, beta, isoform CRA_b)	Ngf NGF, Ngfb, mCG_5471	307	Annotation score:
A0A0G2JEK0	A0A0G2JEK0_MOUSE	Beta-nerve growth factor Beta-nerve growth factor	Ngf	303	Annotation score:
A0A0G2JG51	A0A0G2JG51_MOUSE	Beta-nerve growth factor Beta-nerve growth factor	Ngf	22	Annotation score:

Sequence cautionⁱ

The sequence AAA37687 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAA39818 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAA39820 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAA39821 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAA24221 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	233 – 241	LSRKATRRG → CSAGRLQEEADLPAAPFPTC PLHTLLGPSLPQPVNYFKL in AAB26820 (PubMed:1284621).Curated		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M35075 mRNA Translation: AAA39818.1 Different initiation. V00836 mRNA Translation: CAA24221.1 Different initiation. K01759 mRNA Translation: AAA39820.1 Different initiation. M14805 mRNA Translation: AAA39821.1 Different initiation. M17298, M17296, M17297 Genomic DNA Translation: AAA37687.1 Different initiation. S62089 mRNA Translation: AAB26820.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS51025.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001106168.1, NM_001112698.2 NP_038637.1, NM_013609.3 XP_006501171.1, XM_006501108.3
UniGeneⁱ	Mm.1259

Genome annotation databases

Ensemblⁱ	ENSMUST00000035952; ENSMUSP00000040345; ENSMUSG00000027859
GeneIDⁱ	18049
KEGGⁱ	mmu:18049
UCSC genome browser More...UCSCⁱ	uc012cuz.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01139	Beta-nerve growth factor		MOUSE		307	UniRef100_P01139
UPI00001479E9		MOUSE		120
UPI0000110A30		MOUSE		110
UPI0000112CC6		MOUSE		118
UPI00001108A0		MOUSE		107

Protein	Similar proteins		Species	Score	Length	Source
P01139	Beta-nerve growth factor		RAT		241	UniRef90_P01139
Beta-nerve growth factor		MOUSE		307
Beta-nerve growth factor-like protein		CRIGR		362
Uncharacterized protein		NEOLE		295
UPI000A3165E0		MUSCR		307
+9

Protein	Similar proteins		Species	Score	Length	Source
P01139	Beta-nerve growth factor		RAT		241	UniRef50_P01139
Beta-nerve growth factor		GORGO		241
Beta-nerve growth factor		MOUSE		307
Beta-nerve growth factor-like protein		CRIGR		362
Uncharacterized protein		NEOLE		295
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M35075 mRNA Translation: AAA39818.1 Different initiation. V00836 mRNA Translation: CAA24221.1 Different initiation. K01759 mRNA Translation: AAA39820.1 Different initiation. M14805 mRNA Translation: AAA39821.1 Different initiation. M17298, M17296, M17297 Genomic DNA Translation: AAA37687.1 Different initiation. S62089 mRNA Translation: AAB26820.2
CCDSⁱ	CCDS51025.1
RefSeqⁱ	NP_001106168.1, NM_001112698.2 NP_038637.1, NM_013609.3 XP_006501171.1, XM_006501108.3
UniGeneⁱ	Mm.1259

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BET	X-ray	2.30	A	131-237	[»]
	1BTG	X-ray	2.50	A/B/C	130-239	[»]
	1SGF	X-ray	3.15	B/Y	122-239	[»]
	3IJ2	X-ray	3.75	A/B	19-241	[»]
	4EAX	X-ray	2.30	A/B/C/D	122-241	[»]
	4XPJ	X-ray	2.60	A/B	122-241	[»]
	5LSD	NMR	-	A/B	122-239	[»]
	6FFY	X-ray	3.90	B/C	122-238	[»]
DisProtⁱ	DP00836
ProteinModelPortalⁱ	P01139
SMRⁱ	P01139
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201764, 1 interactor
DIPⁱ	DIP-59840N
IntActⁱ	P01139, 4 interactors
STRINGⁱ	10090.ENSMUSP00000102538

PTM databases

PhosphoSitePlusⁱ	P01139

PhosphoSitePlusⁱ

P01139

Proteomic databases

MaxQBⁱ	P01139
PaxDbⁱ	P01139
PeptideAtlasⁱ	P01139
PRIDEⁱ	P01139

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	18049
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000035952; ENSMUSP00000040345; ENSMUSG00000027859
GeneIDⁱ	18049
KEGGⁱ	mmu:18049
UCSCⁱ	uc012cuz.2 mouse

Organism-specific databases

CTDⁱ	4803
MGIⁱ	MGI:97321 Ngf

Phylogenomic databases

eggNOGⁱ	ENOG410IIPQ Eukaryota ENOG4111F87 LUCA
GeneTreeⁱ	ENSGT00390000007725
HOVERGENⁱ	HBG006494
InParanoidⁱ	P01139
KOⁱ	K02582
PhylomeDBⁱ	P01139

Enzyme and pathway databases

Reactomeⁱ	R-MMU-167060 NGF processing R-MMU-170968 Frs2-mediated activation R-MMU-170984 ARMS-mediated activation R-MMU-177504 Retrograde neurotrophin signalling R-MMU-187042 TRKA activation by NGF R-MMU-198203 PI3K/AKT activation R-MMU-205017 NFG and proNGF binds to p75NTR R-MMU-205025 NADE modulates death signalling R-MMU-205043 NRIF signals cell death from the nucleus R-MMU-209543 p75NTR recruits signalling complexes R-MMU-209560 NF-kB is activated and signals survival R-MMU-209563 Axonal growth stimulation

Reactomeⁱ

R-MMU-167060 NGF processing
R-MMU-170968 Frs2-mediated activation
R-MMU-170984 ARMS-mediated activation
R-MMU-177504 Retrograde neurotrophin signalling
R-MMU-187042 TRKA activation by NGF
R-MMU-198203 PI3K/AKT activation
R-MMU-205017 NFG and proNGF binds to p75NTR
R-MMU-205025 NADE modulates death signalling
R-MMU-205043 NRIF signals cell death from the nucleus
R-MMU-209543 p75NTR recruits signalling complexes
R-MMU-209560 NF-kB is activated and signals survival
R-MMU-209563 Axonal growth stimulation

Miscellaneous databases

EvolutionaryTraceⁱ	P01139
Protein Ontology More...PROⁱ	PR:P01139
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027859 Expressed in 62 organ(s), highest expression level in submandibular gland
CleanExⁱ	MM_NGF
ExpressionAtlasⁱ	P01139 baseline and differential
Genevisibleⁱ	P01139 MM

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020408 Nerve_growth_factor-like IPR002072 Nerve_growth_factor-rel IPR020425 Nerve_growth_factor_bsu IPR020437 Nerve_growth_factor_bsu_mml IPR019846 Nerve_growth_factor_CS
PANTHERⁱ	PTHR11589 PTHR11589, 1 hit
Pfamⁱ	View protein in Pfam PF00243 NGF, 1 hit
PIRSFⁱ	PIRSF001789 NGF, 1 hit
PRINTSⁱ	PR01925 MAMLNGFBETA PR00268 NGF PR01913 NGFBETA
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002052 Nerve_growth_factor-rel, 1 hit
SMARTⁱ	View protein in SMART SM00140 NGF, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00248 NGF_1, 1 hit PS50270 NGF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NGF_MOUSE
Accessionⁱ	P01139Primary (citable) accession number: P01139 Secondary accession number(s): Q63864, Q6LDB7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 1, 1990
	Last modified:	November 7, 2018
	This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P01139 (NGF_MOUSE)

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Beta-nerve growth factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ