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UniProtKB - P01138 (NGF_HUMAN)

Entry version 217 (10 Feb 2021)
Sequence version 3 (21 Mar 2006)
Previous versions | rss
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Protein

Beta-nerve growth factor

Gene

NGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).By similarity2 Publications3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei173a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol); via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei209a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol); shared with dimeric partnerBy similarity1
Binding sitei209a 1-acyl-sn-glycero-3-phospho-L-serine; shared with dimeric partnerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01138

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-167021, PLC-gamma1 signalling
R-HSA-167044, Signalling to RAS
R-HSA-167060, NGF processing
R-HSA-170968, Frs2-mediated activation
R-HSA-170984, ARMS-mediated activation
R-HSA-177504, Retrograde neurotrophin signalling
R-HSA-187042, TRKA activation by NGF
R-HSA-187706, Signalling to p38 via RIT and RIN
R-HSA-193648, NRAGE signals death through JNK
R-HSA-193670, p75NTR negatively regulates cell cycle via SC1
R-HSA-193681, Ceramide signalling
R-HSA-198203, PI3K/AKT activation
R-HSA-198745, Signalling to STAT3
R-HSA-205017, NFG and proNGF binds to p75NTR
R-HSA-205025, NADE modulates death signalling
R-HSA-205043, NRIF signals cell death from the nucleus
R-HSA-209543, p75NTR recruits signalling complexes
R-HSA-209560, NF-kB is activated and signals survival
R-HSA-209563, Axonal growth stimulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P01138

SIGNOR Signaling Network Open Resource

More...SIGNORi		P01138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-nerve growth factor1 Publication
Short name:
Beta-NGF1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NGF
Synonyms:NGFB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7808, NGF

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		162030, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01138

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134259.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neuropathy, hereditary sensory and autonomic, 5 (HSAN5)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068478162E → EGE in HSAN5; uncertain pathological significance. 1 Publication1
Natural variantiVAR_030659221R → W in HSAN5; impaired processing of the precursor to mature NGF; nearly abolishes secretion; loss of function in stimulating cell differentiation; loss of the ability to activate the NTRK1 receptor. 2 PublicationsCorresponds to variant dbSNP:rs11466112EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		4803

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		NGF

MalaCards human disease database

More...MalaCardsi		NGF
MIMi608654, phenotype

Open Targets

More...OpenTargetsi		ENSG00000134259

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		64752, Hereditary sensory and autonomic neuropathy type 5

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162397475

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01138, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1649058

Drug and drug target database

More...DrugBanki		DB01407, Clenbuterol
DB09221, Polaprezinc
DB05892, RI 624

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NGF

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001959919 – 121Add BLAST103
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000019600122 – 241Beta-nerve growth factorAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi136 ↔ 201Combined sources1 Publication
Disulfide bondi179 ↔ 229Combined sources1 Publication
Disulfide bondi189 ↔ 231Combined sources1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01138

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01138

PeptideAtlas

More...PeptideAtlasi		P01138

PRoteomics IDEntifications database

More...PRIDEi		P01138

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51338

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P01138, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01138

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01138

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134259, Expressed in cartilage tissue and 120 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01138, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134259, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:10490030, PubMed:15131306, PubMed:17196528). The homodimer interacts with a single NTRK1 chain (PubMed:10490030, PubMed:17196528). The homodimer interacts with a single NGFR chain (PubMed:15131306). The NGF dimer interacts with a single SORCS2 chain (via extracellular domain) (By similarity). The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis. Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains) (By similarity). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF. The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (By similarity).

Interacts with ADAM10 in a divalent cation-dependent manner (PubMed:20164177).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110869, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P01138

Database of interacting proteins

More...DIPi		DIP-5712N

Protein interaction database and analysis system

More...IntActi		P01138, 7 interactors

Molecular INTeraction database

More...MINTi		P01138

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358525

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P01138

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01138, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01138

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P01138

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RYPU, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007725

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059942_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01138

Identification of Orthologs from Complete Genome Data

More...OMAi		YCTNSHT

Database of Orthologous Groups

More...OrthoDBi		1156054at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01138

TreeFam database of animal gene trees

More...TreeFami		TF106463

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR020408, Nerve_growth_factor-like
IPR002072, Nerve_growth_factor-rel
IPR020425, Nerve_growth_factor_bsu
IPR020437, Nerve_growth_factor_bsu_mml
IPR019846, Nerve_growth_factor_CS

The PANTHER Classification System

More...PANTHERi		PTHR11589, PTHR11589, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00243, NGF, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001789, NGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01925, MAMLNGFBETA
PR00268, NGF
PR01913, NGFBETA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00140, NGF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57501, SSF57501, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00248, NGF_1, 1 hit
PS50270, NGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01138-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR 
        60         70         80         90        100
ARSAPAAAIA ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT 
       110        120        130        140        150
QDLDFEVGGA APFNRTHRSK RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT 
       160        170        180        190        200
DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY 
       210        220        230        240 
CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A
Length:241
Mass (Da):26,959
Last modified:March 21, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i619DFC65EB3BD671
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32517 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164N → S in AAL05874 (Ref. 6) Curated1
Sequence conflicti230V → M in AAL05874 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01378335A → V7 PublicationsCorresponds to variant dbSNP:rs6330EnsemblClinVar.1
Natural variantiVAR_02555372V → M. Corresponds to variant dbSNP:rs11466110EnsemblClinVar.1
Natural variantiVAR_02555480R → Q. Corresponds to variant dbSNP:rs11466111EnsemblClinVar.1
Natural variantiVAR_068478162E → EGE in HSAN5; uncertain pathological significance. 1 Publication1
Natural variantiVAR_068479187S → N Found in a patient with congenital insensitivity to pain; uncertain pathological significance. 1 Publication1
Natural variantiVAR_030659221R → W in HSAN5; impaired processing of the precursor to mature NGF; nearly abolishes secretion; loss of function in stimulating cell differentiation; loss of the ability to activate the NTRK1 receptor. 2 PublicationsCorresponds to variant dbSNP:rs11466112EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
V01511 Genomic DNA Translation: CAA24755.1
M21062 Genomic DNA Translation: AAA59931.1
AF150960 Genomic DNA Translation: AAD55975.1
AB037517 Genomic DNA Translation: BAA90437.1
AF411526 mRNA Translation: AAL05874.1
CR541855 mRNA Translation: CAG46653.1
BT019733 mRNA Translation: AAV38538.1
AL049825 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56629.1
BC032517 mRNA Translation: AAH32517.2 Different initiation.
BC126148 mRNA Translation: AAI26149.1
BC126150 mRNA Translation: AAI26151.1
X52599 mRNA Translation: CAA36832.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS882.1

Protein sequence database of the Protein Information Resource

More...PIRi		A01399, NGHUBM

NCBI Reference Sequences

More...RefSeqi		NP_002497.2, NM_002506.2
XP_006710726.1, XM_006710663.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369512; ENSP00000358525; ENSG00000134259
ENST00000675637; ENSP00000502831; ENSG00000134259
ENST00000676038; ENSP00000502380; ENSG00000134259

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4803

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4803

UCSC genome browser

More...UCSCi		uc001efu.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Nerve growth factor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01511 Genomic DNA Translation: CAA24755.1
M21062 Genomic DNA Translation: AAA59931.1
AF150960 Genomic DNA Translation: AAD55975.1
AB037517 Genomic DNA Translation: BAA90437.1
AF411526 mRNA Translation: AAL05874.1
CR541855 mRNA Translation: CAG46653.1
BT019733 mRNA Translation: AAV38538.1
AL049825 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56629.1
BC032517 mRNA Translation: AAH32517.2 Different initiation.
BC126148 mRNA Translation: AAI26149.1
BC126150 mRNA Translation: AAI26151.1
X52599 mRNA Translation: CAA36832.1
CCDSiCCDS882.1
PIRiA01399, NGHUBM
RefSeqiNP_002497.2, NM_002506.2
XP_006710726.1, XM_006710663.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SG1X-ray2.40A/B122-241[»]
1WWWX-ray2.20V/W122-241[»]
2IFGX-ray3.40E/F122-241[»]
4EDWX-ray2.48V122-241[»]
4EDXX-ray2.50V/W122-241[»]
4ZBNX-ray2.45A/B122-241[»]
5JZ7X-ray3.40A/B/E/F128-237[»]
SMRiP01138
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110869, 8 interactors
CORUMiP01138
DIPiDIP-5712N
IntActiP01138, 7 interactors
MINTiP01138
STRINGi9606.ENSP00000358525

Chemistry databases

BindingDBiP01138
ChEMBLiCHEMBL1649058
DrugBankiDB01407, Clenbuterol
DB09221, Polaprezinc
DB05892, RI 624

PTM databases

GlyGeniP01138, 2 sites
iPTMnetiP01138
PhosphoSitePlusiP01138

Genetic variation databases

BioMutaiNGF

Proteomic databases

MassIVEiP01138
PaxDbiP01138
PeptideAtlasiP01138
PRIDEiP01138
ProteomicsDBi51338

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P01138, 71 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20173, 1058 antibodies

The DNASU plasmid repository

More...DNASUi		4803

Genome annotation databases

EnsembliENST00000369512; ENSP00000358525; ENSG00000134259
ENST00000675637; ENSP00000502831; ENSG00000134259
ENST00000676038; ENSP00000502380; ENSG00000134259
GeneIDi4803
KEGGihsa:4803
UCSCiuc001efu.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4803
DisGeNETi4803

GeneCards: human genes, protein and diseases

More...GeneCardsi		NGF
GeneReviewsiNGF
HGNCiHGNC:7808, NGF
HPAiENSG00000134259, Low tissue specificity
MalaCardsiNGF
MIMi162030, gene
608654, phenotype
neXtProtiNX_P01138
OpenTargetsiENSG00000134259
Orphaneti64752, Hereditary sensory and autonomic neuropathy type 5
PharmGKBiPA162397475
VEuPathDBiHostDB:ENSG00000134259.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RYPU, Eukaryota
GeneTreeiENSGT00390000007725
HOGENOMiCLU_059942_1_1_1
InParanoidiP01138
OMAiYCTNSHT
OrthoDBi1156054at2759
PhylomeDBiP01138
TreeFamiTF106463

Enzyme and pathway databases

PathwayCommonsiP01138
ReactomeiR-HSA-167021, PLC-gamma1 signalling
R-HSA-167044, Signalling to RAS
R-HSA-167060, NGF processing
R-HSA-170968, Frs2-mediated activation
R-HSA-170984, ARMS-mediated activation
R-HSA-177504, Retrograde neurotrophin signalling
R-HSA-187042, TRKA activation by NGF
R-HSA-187706, Signalling to p38 via RIT and RIN
R-HSA-193648, NRAGE signals death through JNK
R-HSA-193670, p75NTR negatively regulates cell cycle via SC1
R-HSA-193681, Ceramide signalling
R-HSA-198203, PI3K/AKT activation
R-HSA-198745, Signalling to STAT3
R-HSA-205017, NFG and proNGF binds to p75NTR
R-HSA-205025, NADE modulates death signalling
R-HSA-205043, NRIF signals cell death from the nucleus
R-HSA-209543, p75NTR recruits signalling complexes
R-HSA-209560, NF-kB is activated and signals survival
R-HSA-209563, Axonal growth stimulation
SignaLinkiP01138
SIGNORiP01138

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4803, 4 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NGF, human
EvolutionaryTraceiP01138

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Nerve_growth_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4803
PharosiP01138, Tchem

Protein Ontology

More...PROi		PR:P01138
RNActiP01138, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134259, Expressed in cartilage tissue and 120 other tissues
GenevisibleiP01138, HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR020408, Nerve_growth_factor-like
IPR002072, Nerve_growth_factor-rel
IPR020425, Nerve_growth_factor_bsu
IPR020437, Nerve_growth_factor_bsu_mml
IPR019846, Nerve_growth_factor_CS
PANTHERiPTHR11589, PTHR11589, 1 hit
PfamiView protein in Pfam
PF00243, NGF, 1 hit
PIRSFiPIRSF001789, NGF, 1 hit
PRINTSiPR01925, MAMLNGFBETA
PR00268, NGF
PR01913, NGFBETA
SMARTiView protein in SMART
SM00140, NGF, 1 hit
SUPFAMiSSF57501, SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248, NGF_1, 1 hit
PS50270, NGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNGF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01138
Secondary accession number(s): A1A4E5
, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 21, 2006
Last modified: February 10, 2021
This is version 217 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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