NGF

Functionⁱ

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).1 Publication

GO - Molecular functionⁱ

cysteine-type endopeptidase activator activity involved in apoptotic process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 11927634
death receptor agonist activity
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 11927634
growth factor activity Source: GO_Central
metalloendopeptidase inhibitor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20164177
nerve growth factor receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14985763

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 11927634
activation of MAPKK activity Source: Reactome
cell-cell signaling Source: GO_Central
extrinsic apoptotic signaling pathway via death domain receptors
Source: BHF-UCL
Inferred from direct assayⁱ
- 14985763
negative regulation of apoptotic process Source: Reactome
negative regulation of cell proliferation
Source: ARUK-UCL
Traceable author statementⁱ
- 10362258
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
negative regulation of neuron apoptotic process Source: GO_Central
nerve growth factor processing Source: Reactome
neuron apoptotic process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 11927634
neuron projection morphogenesis
Source: MGI
Inferred from direct assayⁱ
- 17724343
neurotrophin TRK receptor signaling pathway Source: Reactome
phosphatidylinositol-mediated signaling Source: Reactome
positive regulation of apoptotic process Source: Reactome
positive regulation of axonogenesis Source: Reactome
positive regulation of DNA binding
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 10362258
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16153003
positive regulation of neuron differentiation
Source: ARUK-UCL
Traceable author statementⁱ
- 10362258
positive regulation of Ras protein signal transduction Source: ParkinsonsUK-UCL
regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
regulation of neuron differentiation Source: GO_Central
transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Molecular function

Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167021 PLC-gamma1 signalling R-HSA-167044 Signalling to RAS R-HSA-167060 NGF processing R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177504 Retrograde neurotrophin signalling R-HSA-187042 TRKA activation by NGF R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-193648 NRAGE signals death through JNK R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 R-HSA-193681 Ceramide signalling R-HSA-198203 PI3K/AKT activation R-HSA-198745 Signalling to STAT3 R-HSA-205017 NFG and proNGF binds to p75NTR R-HSA-205025 NADE modulates death signalling R-HSA-205043 NRIF signals cell death from the nucleus R-HSA-209543 p75NTR recruits signalling complexes R-HSA-209560 NF-kB is activated and signals survival R-HSA-209563 Axonal growth stimulation
SignaLinkⁱ	P01138
SIGNORⁱ	P01138

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-nerve growth factor Short name: Beta-NGF
Gene namesⁱ	Name:NGF Synonyms:NGFB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134259.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7808 NGF
MIMⁱ	162030 gene
neXtProtⁱ	NX_P01138

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Neuropathy, hereditary sensory and autonomic, 5 (HSAN5)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_068478	162	E → EGE in HSAN5; uncertain pathological significance. 1 Publication		1
Natural variantⁱVAR_030659	221	R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor. 2 PublicationsCorresponds to variant dbSNP:rs11466112EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4803
MalaCards human disease database More...MalaCardsⁱ	NGF
MIMⁱ	608654 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000134259
Orphanetⁱ	64752 Hereditary sensory and autonomic neuropathy type 5
PharmGKBⁱ	PA162397475

Chemistry databases

ChEMBLⁱ	CHEMBL1649058
Drug and drug target database More...DrugBankⁱ	DB01407 Clenbuterol DB05892 RI 624

Polymorphism and mutation databases

BioMutaⁱ	NGF

BioMutaⁱ

NGF

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST	18
PropeptideⁱPRO_0000019599	19 – 121	Add BLAST	103
ChainⁱPRO_0000019600	122 – 241	Beta-nerve growth factorAdd BLAST	120

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	69	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	136 ↔ 201	1 Publication
Disulfide bondⁱ	179 ↔ 229	1 Publication
Disulfide bondⁱ	189 ↔ 231	1 Publication

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P01138
PeptideAtlas More...PeptideAtlasⁱ	P01138
PRIDEⁱ	P01138
ProteomicsDBⁱ	51338

PTM databases

iPTMnetⁱ	P01138
PhosphoSitePlusⁱ	P01138

Miscellaneous databases

PMAP-CutDBⁱ	P01138

PMAP-CutDBⁱ

P01138

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134259
CleanExⁱ	HS_NGF
Genevisibleⁱ	P01138 HS

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NGFR	P08138	2	EBI-1028250,EBI-1387782
Ngfr	P07174	3	EBI-1028250,EBI-1038810	From Rattus norvegicus.
NTRK1	P04629	3	EBI-1028250,EBI-1028226
SORCS3	Q9UPU3	3	EBI-1028250,EBI-7484437
SORT1	Q99523	5	EBI-1028250,EBI-1057058

Show more details

GO - Molecular functionⁱ

death receptor agonist activity
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 11927634
growth factor activity Source: GO_Central
nerve growth factor receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14985763

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110869, 6 interactors
CORUMⁱ	P01138
Database of interacting proteins More...DIPⁱ	DIP-5712N
IntActⁱ	P01138, 6 interactors
Molecular INTeraction database More...MINTⁱ	P01138
STRINGⁱ	9606.ENSP00000358525

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	127 – 130	Combined sources	4
Beta strandⁱ	133 – 136	Combined sources	4
Beta strandⁱ	138 – 143	Combined sources	6
Beta strandⁱ	148 – 151	Combined sources	4
Beta strandⁱ	156 – 159	Combined sources	4
Beta strandⁱ	161 – 171	Combined sources	11
Beta strandⁱ	174 – 179	Combined sources	6
Beta strandⁱ	190 – 192	Combined sources	3
Turnⁱ	194 – 196	Combined sources	3
Beta strandⁱ	197 – 213	Combined sources	17
Beta strandⁱ	215 – 235	Combined sources	21

3D structure databases

ProteinModelPortalⁱ	P01138
SMRⁱ	P01138
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P01138

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NGF-beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IIPQ Eukaryota ENOG4111F87 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007725
HOGENOMⁱ	HOG000231516
HOVERGENⁱ	HBG006494
InParanoidⁱ	P01138
KEGG Orthology (KO) More...KOⁱ	K02582
OMAⁱ	NNVFKQY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GHL
PhylomeDBⁱ	P01138
TreeFamⁱ	TF106463

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020408 Nerve_growth_factor-like IPR002072 Nerve_growth_factor-rel IPR020425 Nerve_growth_factor_bsu IPR020437 Nerve_growth_factor_bsu_mml IPR019846 Nerve_growth_factor_CS
PANTHERⁱ	PTHR11589 PTHR11589, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00243 NGF, 1 hit
PIRSFⁱ	PIRSF001789 NGF, 1 hit
PRINTSⁱ	PR01925 MAMLNGFBETA PR00268 NGF PR01913 NGFBETA
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002052 Nerve_growth_factor-rel, 1 hit
SMARTⁱ	View protein in SMART SM00140 NGF, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00248 NGF_1, 1 hit PS50270 NGF_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01138-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR 
        60         70         80         90        100
ARSAPAAAIA ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT 
       110        120        130        140        150
QDLDFEVGGA APFNRTHRSK RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT 
       160        170        180        190        200
DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY 
       210        220        230        240 
CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A

Length:241

Mass (Da):26,959

Last modified:March 21, 2006 - v3

Checksum:ⁱ619DFC65EB3BD671

GO

Sequence cautionⁱ

The sequence AAH32517 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	164	N → S in AAL05874 (Ref. 6) Curated		1
Sequence conflictⁱ	230	V → M in AAL05874 (Ref. 6) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013783	35	A → V7 PublicationsCorresponds to variant dbSNP:rs6330EnsemblClinVar.	1
Natural variantⁱVAR_025553	72	V → M. Corresponds to variant dbSNP:rs11466110EnsemblClinVar.	1
Natural variantⁱVAR_025554	80	R → Q. Corresponds to variant dbSNP:rs11466111EnsemblClinVar.	1
Natural variantⁱVAR_068478	162	E → EGE in HSAN5; uncertain pathological significance. 1 Publication	1
Natural variantⁱVAR_068479	187	S → N Found in a patient with congenital insensitivity to pain; uncertain pathological significance. 1 Publication	1
Natural variantⁱVAR_030659	221	R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor. 2 PublicationsCorresponds to variant dbSNP:rs11466112EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V01511 Genomic DNA Translation: CAA24755.1 M21062 Genomic DNA Translation: AAA59931.1 AF150960 Genomic DNA Translation: AAD55975.1 AB037517 Genomic DNA Translation: BAA90437.1 AF411526 mRNA Translation: AAL05874.1 CR541855 mRNA Translation: CAG46653.1 BT019733 mRNA Translation: AAV38538.1 AL049825 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56629.1 BC032517 mRNA Translation: AAH32517.2 Different initiation. BC126148 mRNA Translation: AAI26149.1 BC126150 mRNA Translation: AAI26151.1 X52599 mRNA Translation: CAA36832.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS882.1
PIRⁱ	A01399 NGHUBM
NCBI Reference Sequences More...RefSeqⁱ	NP_002497.2, NM_002506.2 XP_006710726.1, XM_006710663.3
UniGeneⁱ	Hs.2561

Genome annotation databases

Ensemblⁱ	ENST00000369512; ENSP00000358525; ENSG00000134259
GeneIDⁱ	4803
KEGGⁱ	hsa:4803
UCSC genome browser More...UCSCⁱ	uc001efu.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P01138	UPI0005D00584		HUMAN		296
UPI00045E51FE		CHLSB		296
UPI00083C046A		RHIBE		294
Nerve growth factor		FELCA		294
UPI00072DDF9E		ACIJB		223
+19

Protein	Similar proteins		Species	Score	Length
P01138	UPI0005D00584		HUMAN		296
UPI00045E51FE		CHLSB		296
UPI00083C046A		RHIBE		294
Nerve growth factor		FELCA		294
UPI00072DDF9E		ACIJB		223
+351

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Nerve growth factor entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V01511 Genomic DNA Translation: CAA24755.1 M21062 Genomic DNA Translation: AAA59931.1 AF150960 Genomic DNA Translation: AAD55975.1 AB037517 Genomic DNA Translation: BAA90437.1 AF411526 mRNA Translation: AAL05874.1 CR541855 mRNA Translation: CAG46653.1 BT019733 mRNA Translation: AAV38538.1 AL049825 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56629.1 BC032517 mRNA Translation: AAH32517.2 Different initiation. BC126148 mRNA Translation: AAI26149.1 BC126150 mRNA Translation: AAI26151.1 X52599 mRNA Translation: CAA36832.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS882.1
PIRⁱ	A01399 NGHUBM
NCBI Reference Sequences More...RefSeqⁱ	NP_002497.2, NM_002506.2 XP_006710726.1, XM_006710663.3
UniGeneⁱ	Hs.2561

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1SG1	X-ray	2.40	A/B	122-241	[»]
	1WWW	X-ray	2.20	V/W	122-241	[»]
	2IFG	X-ray	3.40	E/F	122-241	[»]
	4EDW	X-ray	2.48	V	122-241	[»]
	4EDX	X-ray	2.50	V/W	122-241	[»]
	4ZBN	X-ray	2.45	A/B	122-241	[»]
	5JZ7	X-ray	3.40	A/B/E/F	128-237	[»]
ProteinModelPortalⁱ	P01138
SMRⁱ	P01138
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110869, 6 interactors
CORUMⁱ	P01138
Database of interacting proteins More...DIPⁱ	DIP-5712N
IntActⁱ	P01138, 6 interactors
Molecular INTeraction database More...MINTⁱ	P01138
STRINGⁱ	9606.ENSP00000358525

Chemistry databases

ChEMBLⁱ	CHEMBL1649058
Drug and drug target database More...DrugBankⁱ	DB01407 Clenbuterol DB05892 RI 624

PTM databases

iPTMnetⁱ	P01138
PhosphoSitePlusⁱ	P01138

Polymorphism and mutation databases

BioMutaⁱ	NGF

BioMutaⁱ

NGF

Proteomic databases

PaxDbⁱ	P01138
PeptideAtlas More...PeptideAtlasⁱ	P01138
PRIDEⁱ	P01138
ProteomicsDBⁱ	51338

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4803
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369512; ENSP00000358525; ENSG00000134259
GeneIDⁱ	4803
KEGGⁱ	hsa:4803
UCSC genome browser More...UCSCⁱ	uc001efu.2 human

Organism-specific databases

CTDⁱ	4803
DisGeNET More...DisGeNETⁱ	4803
EuPathDBⁱ	HostDB:ENSG00000134259.3
GeneCardsⁱ	NGF
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7808 NGF
MalaCards human disease database More...MalaCardsⁱ	NGF
MIMⁱ	162030 gene 608654 phenotype
neXtProtⁱ	NX_P01138
Open Targets More...OpenTargetsⁱ	ENSG00000134259
Orphanetⁱ	64752 Hereditary sensory and autonomic neuropathy type 5
PharmGKBⁱ	PA162397475
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIPQ Eukaryota ENOG4111F87 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007725
HOGENOMⁱ	HOG000231516
HOVERGENⁱ	HBG006494
InParanoidⁱ	P01138
KEGG Orthology (KO) More...KOⁱ	K02582
OMAⁱ	NNVFKQY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GHL
PhylomeDBⁱ	P01138
TreeFamⁱ	TF106463

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167021 PLC-gamma1 signalling R-HSA-167044 Signalling to RAS R-HSA-167060 NGF processing R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177504 Retrograde neurotrophin signalling R-HSA-187042 TRKA activation by NGF R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-193648 NRAGE signals death through JNK R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 R-HSA-193681 Ceramide signalling R-HSA-198203 PI3K/AKT activation R-HSA-198745 Signalling to STAT3 R-HSA-205017 NFG and proNGF binds to p75NTR R-HSA-205025 NADE modulates death signalling R-HSA-205043 NRIF signals cell death from the nucleus R-HSA-209543 p75NTR recruits signalling complexes R-HSA-209560 NF-kB is activated and signals survival R-HSA-209563 Axonal growth stimulation
SignaLinkⁱ	P01138
SIGNORⁱ	P01138

Miscellaneous databases

EvolutionaryTraceⁱ	P01138
GeneWikiⁱ	Nerve_growth_factor
GenomeRNAiⁱ	4803
PMAP-CutDBⁱ	P01138
Protein Ontology More...PROⁱ	PR:P01138
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134259
CleanExⁱ	HS_NGF
Genevisibleⁱ	P01138 HS

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020408 Nerve_growth_factor-like IPR002072 Nerve_growth_factor-rel IPR020425 Nerve_growth_factor_bsu IPR020437 Nerve_growth_factor_bsu_mml IPR019846 Nerve_growth_factor_CS
PANTHERⁱ	PTHR11589 PTHR11589, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00243 NGF, 1 hit
PIRSFⁱ	PIRSF001789 NGF, 1 hit
PRINTSⁱ	PR01925 MAMLNGFBETA PR00268 NGF PR01913 NGFBETA
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002052 Nerve_growth_factor-rel, 1 hit
SMARTⁱ	View protein in SMART SM00140 NGF, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00248 NGF_1, 1 hit PS50270 NGF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NGF_HUMAN
Accessionⁱ	P01138Primary (citable) accession number: P01138 Secondary accession number(s): A1A4E5 , Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	March 21, 2006
	Last modified:	July 18, 2018
	This is version 198 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01138 (NGF_HUMAN)

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Beta-nerve growth factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endosome

Extracellular region or secreted

Golgi apparatus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ