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Entry version 203 (13 Feb 2019)
Sequence version 3 (21 Mar 2006)
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Protein

Beta-nerve growth factor

Gene

NGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cysteine-type endopeptidase activator activity involved in apoptotic process Source: ARUK-UCL
  • death receptor agonist activity Source: ARUK-UCL
  • growth factor activity Source: GO_Central
  • metalloendopeptidase inhibitor activity Source: UniProtKB
  • nerve growth factor receptor binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-167021 PLC-gamma1 signalling
R-HSA-167044 Signalling to RAS
R-HSA-167060 NGF processing
R-HSA-170968 Frs2-mediated activation
R-HSA-170984 ARMS-mediated activation
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-187042 TRKA activation by NGF
R-HSA-187706 Signalling to p38 via RIT and RIN
R-HSA-193648 NRAGE signals death through JNK
R-HSA-193670 p75NTR negatively regulates cell cycle via SC1
R-HSA-193681 Ceramide signalling
R-HSA-198203 PI3K/AKT activation
R-HSA-198745 Signalling to STAT3
R-HSA-205017 NFG and proNGF binds to p75NTR
R-HSA-205025 NADE modulates death signalling
R-HSA-205043 NRIF signals cell death from the nucleus
R-HSA-209543 p75NTR recruits signalling complexes
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-209563 Axonal growth stimulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P01138

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-nerve growth factor
Short name:
Beta-NGF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NGF
Synonyms:NGFB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134259.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7808 NGF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
162030 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01138

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neuropathy, hereditary sensory and autonomic, 5 (HSAN5)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.
See also OMIM:608654
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068478162E → EGE in HSAN5; uncertain pathological significance. 1 Publication1
Natural variantiVAR_030659221R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor. 2 PublicationsCorresponds to variant dbSNP:rs11466112EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
4803

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
NGF

MalaCards human disease database

More...
MalaCardsi
NGF
MIMi608654 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134259

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
64752 Hereditary sensory and autonomic neuropathy type 5

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397475

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1649058

Drug and drug target database

More...
DrugBanki
DB01407 Clenbuterol
DB05892 RI 624

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NGF

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001959919 – 121Add BLAST103
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000019600122 – 241Beta-nerve growth factorAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi136 ↔ 2011 Publication
Disulfide bondi179 ↔ 2291 Publication
Disulfide bondi189 ↔ 2311 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01138

PeptideAtlas

More...
PeptideAtlasi
P01138

PRoteomics IDEntifications database

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PRIDEi
P01138

ProteomicsDB human proteome resource

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ProteomicsDBi
51338

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01138

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01138

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01138

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134259 Expressed in 96 organ(s), highest expression level in cartilage tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P01138 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110869, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P01138

Database of interacting proteins

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DIPi
DIP-5712N

Protein interaction database and analysis system

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IntActi
P01138, 5 interactors

Molecular INTeraction database

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MINTi
P01138

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358525

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SG1X-ray2.40A/B122-241[»]
1WWWX-ray2.20V/W122-241[»]
2IFGX-ray3.40E/F122-241[»]
4EDWX-ray2.48V122-241[»]
4EDXX-ray2.50V/W122-241[»]
4ZBNX-ray2.45A/B122-241[»]
5JZ7X-ray3.40A/B/E/F128-237[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01138

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01138

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01138

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIPQ Eukaryota
ENOG4111F87 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157754

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231516

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006494

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01138

KEGG Orthology (KO)

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KOi
K02582

Identification of Orthologs from Complete Genome Data

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OMAi
RTKRTAH

Database of Orthologous Groups

More...
OrthoDBi
1156054at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01138

TreeFam database of animal gene trees

More...
TreeFami
TF106463

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR020425 Nerve_growth_factor_bsu
IPR020437 Nerve_growth_factor_bsu_mml
IPR019846 Nerve_growth_factor_CS

The PANTHER Classification System

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PANTHERi
PTHR11589 PTHR11589, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00243 NGF, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001789 NGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01925 MAMLNGFBETA
PR00268 NGF
PR01913 NGFBETA

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00140 NGF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01138-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR
60 70 80 90 100
ARSAPAAAIA ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT
110 120 130 140 150
QDLDFEVGGA APFNRTHRSK RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT
160 170 180 190 200
DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY
210 220 230 240
CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A
Length:241
Mass (Da):26,959
Last modified:March 21, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i619DFC65EB3BD671
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32517 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164N → S in AAL05874 (Ref. 6) Curated1
Sequence conflicti230V → M in AAL05874 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01378335A → V7 PublicationsCorresponds to variant dbSNP:rs6330EnsemblClinVar.1
Natural variantiVAR_02555372V → M. Corresponds to variant dbSNP:rs11466110EnsemblClinVar.1
Natural variantiVAR_02555480R → Q. Corresponds to variant dbSNP:rs11466111EnsemblClinVar.1
Natural variantiVAR_068478162E → EGE in HSAN5; uncertain pathological significance. 1 Publication1
Natural variantiVAR_068479187S → N Found in a patient with congenital insensitivity to pain; uncertain pathological significance. 1 Publication1
Natural variantiVAR_030659221R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor. 2 PublicationsCorresponds to variant dbSNP:rs11466112EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V01511 Genomic DNA Translation: CAA24755.1
M21062 Genomic DNA Translation: AAA59931.1
AF150960 Genomic DNA Translation: AAD55975.1
AB037517 Genomic DNA Translation: BAA90437.1
AF411526 mRNA Translation: AAL05874.1
CR541855 mRNA Translation: CAG46653.1
BT019733 mRNA Translation: AAV38538.1
AL049825 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56629.1
BC032517 mRNA Translation: AAH32517.2 Different initiation.
BC126148 mRNA Translation: AAI26149.1
BC126150 mRNA Translation: AAI26151.1
X52599 mRNA Translation: CAA36832.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS882.1

Protein sequence database of the Protein Information Resource

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PIRi
A01399 NGHUBM

NCBI Reference Sequences

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RefSeqi
NP_002497.2, NM_002506.2
XP_006710726.1, XM_006710663.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2561

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369512; ENSP00000358525; ENSG00000134259

Database of genes from NCBI RefSeq genomes

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GeneIDi
4803

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4803

UCSC genome browser

More...
UCSCi
uc001efu.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Nerve growth factor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01511 Genomic DNA Translation: CAA24755.1
M21062 Genomic DNA Translation: AAA59931.1
AF150960 Genomic DNA Translation: AAD55975.1
AB037517 Genomic DNA Translation: BAA90437.1
AF411526 mRNA Translation: AAL05874.1
CR541855 mRNA Translation: CAG46653.1
BT019733 mRNA Translation: AAV38538.1
AL049825 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56629.1
BC032517 mRNA Translation: AAH32517.2 Different initiation.
BC126148 mRNA Translation: AAI26149.1
BC126150 mRNA Translation: AAI26151.1
X52599 mRNA Translation: CAA36832.1
CCDSiCCDS882.1
PIRiA01399 NGHUBM
RefSeqiNP_002497.2, NM_002506.2
XP_006710726.1, XM_006710663.3
UniGeneiHs.2561

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SG1X-ray2.40A/B122-241[»]
1WWWX-ray2.20V/W122-241[»]
2IFGX-ray3.40E/F122-241[»]
4EDWX-ray2.48V122-241[»]
4EDXX-ray2.50V/W122-241[»]
4ZBNX-ray2.45A/B122-241[»]
5JZ7X-ray3.40A/B/E/F128-237[»]
ProteinModelPortaliP01138
SMRiP01138
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110869, 6 interactors
CORUMiP01138
DIPiDIP-5712N
IntActiP01138, 5 interactors
MINTiP01138
STRINGi9606.ENSP00000358525

Chemistry databases

ChEMBLiCHEMBL1649058
DrugBankiDB01407 Clenbuterol
DB05892 RI 624

PTM databases

iPTMnetiP01138
PhosphoSitePlusiP01138

Polymorphism and mutation databases

BioMutaiNGF

Proteomic databases

PaxDbiP01138
PeptideAtlasiP01138
PRIDEiP01138
ProteomicsDBi51338

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4803
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369512; ENSP00000358525; ENSG00000134259
GeneIDi4803
KEGGihsa:4803
UCSCiuc001efu.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4803
DisGeNETi4803
EuPathDBiHostDB:ENSG00000134259.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NGF
GeneReviewsiNGF
HGNCiHGNC:7808 NGF
MalaCardsiNGF
MIMi162030 gene
608654 phenotype
neXtProtiNX_P01138
OpenTargetsiENSG00000134259
Orphaneti64752 Hereditary sensory and autonomic neuropathy type 5
PharmGKBiPA162397475

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIPQ Eukaryota
ENOG4111F87 LUCA
GeneTreeiENSGT00940000157754
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP01138
KOiK02582
OMAiRTKRTAH
OrthoDBi1156054at2759
PhylomeDBiP01138
TreeFamiTF106463

Enzyme and pathway databases

ReactomeiR-HSA-167021 PLC-gamma1 signalling
R-HSA-167044 Signalling to RAS
R-HSA-167060 NGF processing
R-HSA-170968 Frs2-mediated activation
R-HSA-170984 ARMS-mediated activation
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-187042 TRKA activation by NGF
R-HSA-187706 Signalling to p38 via RIT and RIN
R-HSA-193648 NRAGE signals death through JNK
R-HSA-193670 p75NTR negatively regulates cell cycle via SC1
R-HSA-193681 Ceramide signalling
R-HSA-198203 PI3K/AKT activation
R-HSA-198745 Signalling to STAT3
R-HSA-205017 NFG and proNGF binds to p75NTR
R-HSA-205025 NADE modulates death signalling
R-HSA-205043 NRIF signals cell death from the nucleus
R-HSA-209543 p75NTR recruits signalling complexes
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-209563 Axonal growth stimulation
SignaLinkiP01138
SIGNORiP01138

Miscellaneous databases

EvolutionaryTraceiP01138

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Nerve_growth_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4803
PMAP-CutDBiP01138

Protein Ontology

More...
PROi
PR:P01138

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134259 Expressed in 96 organ(s), highest expression level in cartilage tissue
GenevisibleiP01138 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR020425 Nerve_growth_factor_bsu
IPR020437 Nerve_growth_factor_bsu_mml
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01925 MAMLNGFBETA
PR00268 NGF
PR01913 NGFBETA
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNGF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01138
Secondary accession number(s): A1A4E5
, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 21, 2006
Last modified: February 13, 2019
This is version 203 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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