UniProtKB - P01133 (EGF_HUMAN)
Pro-epidermal growth factor
EGF
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
- epidermal growth factor receptor binding Source: UniProtKB
- growth factor activity Source: HGNC-UCL
- Ras guanyl-nucleotide exchange factor activity Source: UniProtKB
- transmembrane receptor protein tyrosine kinase activator activity Source: UniProtKB
GO - Biological processi
- activation of MAPK activity Source: Ensembl
- activation of MAPKK activity Source: Ensembl
- angiogenesis Source: HGNC-UCL
- branching morphogenesis of an epithelial tube Source: Ensembl
- epidermal growth factor receptor signaling pathway Source: BHF-UCL
- ERBB2 signaling pathway Source: Reactome
- ERK1 and ERK2 cascade Source: UniProtKB
- mammary gland alveolus development Source: Ensembl
- MAPK cascade Source: Reactome
- membrane organization Source: Reactome
- negative regulation of cholesterol efflux Source: Ensembl
- negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
- negative regulation of ERBB signaling pathway Source: Reactome
- negative regulation of Notch signaling pathway Source: Reactome
- negative regulation of secretion Source: BHF-UCL
- peptidyl-tyrosine phosphorylation Source: Ensembl
- platelet degranulation Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: HGNC-UCL
- positive regulation of cerebellar granule cell precursor proliferation Source: Ensembl
- positive regulation of DNA binding Source: UniProtKB
- positive regulation of DNA replication Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: BHF-UCL
- positive regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
- positive regulation of epithelial tube formation Source: BHF-UCL
- positive regulation of gene expression Source: UniProtKB
- positive regulation of hyaluronan biosynthetic process Source: UniProtKB
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of MAP kinase activity Source: HGNC-UCL
- positive regulation of mitotic nuclear division Source: HGNC-UCL
- positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of phosphorylation Source: HGNC-UCL
- positive regulation of protein kinase B signaling Source: BHF-UCL
- positive regulation of protein localization to early endosome Source: UniProtKB
- positive regulation of receptor internalization Source: ParkinsonsUK-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of ubiquitin-dependent protein catabolic process Source: Ensembl
- regulation of calcium ion import Source: BHF-UCL
- regulation of cell motility Source: Reactome
- regulation of protein localization to cell surface Source: BHF-UCL
- regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
- signal transduction Source: Reactome
Keywordsi
Molecular function | Growth factor |
Enzyme and pathway databases
PathwayCommonsi | P01133 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1227986, Signaling by ERBB2 R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236394, Signaling by ERBB4 R-HSA-1250196, SHC1 events in ERBB2 signaling R-HSA-1251932, PLCG1 events in ERBB2 signaling R-HSA-1257604, PIP3 activates AKT signaling R-HSA-177929, Signaling by EGFR R-HSA-179812, GRB2 events in EGFR signaling R-HSA-180292, GAB1 signalosome R-HSA-180336, SHC1 events in EGFR signaling R-HSA-182971, EGFR downregulation R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-1963642, PI3K events in ERBB2 signaling R-HSA-212718, EGFR interacts with phospholipase C-gamma R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5637810, Constitutive Signaling by EGFRvIII R-HSA-5638303, Inhibition of Signaling by Overexpressed EGFR R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785631, ERBB2 Regulates Cell Motility R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8847993, ERBB2 Activates PTK6 Signaling R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8863795, Downregulation of ERBB2 signaling R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9664565, Signaling by ERBB2 KD Mutants R-HSA-9665348, Signaling by ERBB2 ECD mutants R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants |
SignaLinki | P01133 |
SIGNORi | P01133 |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-epidermal growth factorShort name: EGF Cleaved into the following chain: Alternative name(s): Urogastrone |
Gene namesi | Name:EGF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138798.11 |
HGNCi | HGNC:3229, EGF |
MIMi | 131530, gene |
neXtProti | NX_P01133 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- clathrin-coated vesicle membrane Source: Reactome
- integral component of membrane Source: UniProtKB-KW
- platelet alpha granule lumen Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 1032 | ExtracellularSequence analysisAdd BLAST | 1010 | |
Transmembranei | 1033 – 1053 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1054 – 1207 | CytoplasmicSequence analysisAdd BLAST | 154 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Hypomagnesemia 4 (HOMG4)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039474 | 1070 | P → L in HOMG4; affects basolateral sorting of pro-EGF preventing the hormone to stimulate EGFR; lack of TRPM6 activation. 1 PublicationCorresponds to variant dbSNP:rs121434567EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutation, Primary hypomagnesemiaOrganism-specific databases
DisGeNETi | 1950 |
MalaCardsi | EGF |
MIMi | 611718, phenotype |
OpenTargetsi | ENSG00000138798 |
Orphaneti | 210159, Adult hepatocellular carcinoma 34527, Familial primary hypomagnesemia with normocalciuria and normocalcemia |
PharmGKBi | PA27664 |
Miscellaneous databases
Pharosi | P01133, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5734 |
DrugBanki | DB04454, Alpha-Aminobutyric Acid DB08862, Cholecystokinin DB00364, Sucralfate DB11973, Tesevatinib |
Polymorphism and mutation databases
BioMutai | EGF |
DMDMi | 251757262 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000007540 | 23 – 1207 | Pro-epidermal growth factorAdd BLAST | 1185 | |
ChainiPRO_0000007541 | 971 – 1023 | Epidermal growth factorAdd BLAST | 53 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 318 ↔ 330 | PROSITE-ProRule annotation | ||
Glycosylationi | 324 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 325 ↔ 339 | PROSITE-ProRule annotation | ||
Disulfide bondi | 341 ↔ 354 | PROSITE-ProRule annotation | ||
Disulfide bondi | 360 ↔ 371 | PROSITE-ProRule annotation | ||
Disulfide bondi | 367 ↔ 380 | PROSITE-ProRule annotation | ||
Disulfide bondi | 382 ↔ 395 | PROSITE-ProRule annotation | ||
Disulfide bondi | 401 ↔ 412 | PROSITE-ProRule annotation | ||
Glycosylationi | 404 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 408 ↔ 421 | PROSITE-ProRule annotation | ||
Disulfide bondi | 423 ↔ 436 | PROSITE-ProRule annotation | ||
Disulfide bondi | 439 ↔ 451 | PROSITE-ProRule annotation | ||
Disulfide bondi | 447 ↔ 461 | PROSITE-ProRule annotation | ||
Disulfide bondi | 463 ↔ 476 | PROSITE-ProRule annotation | ||
Glycosylationi | 596 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 745 ↔ 756 | PROSITE-ProRule annotation | ||
Disulfide bondi | 752 ↔ 765 | PROSITE-ProRule annotation | ||
Disulfide bondi | 767 ↔ 780 | PROSITE-ProRule annotation | ||
Glycosylationi | 815 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 835 ↔ 846 | PROSITE-ProRule annotation | ||
Disulfide bondi | 840 ↔ 855 | PROSITE-ProRule annotation | ||
Disulfide bondi | 857 ↔ 868 | PROSITE-ProRule annotation | ||
Disulfide bondi | 874 ↔ 888 | PROSITE-ProRule annotation | ||
Disulfide bondi | 881 ↔ 897 | PROSITE-ProRule annotation | ||
Disulfide bondi | 899 ↔ 910 | PROSITE-ProRule annotation | ||
Disulfide bondi | 916 ↔ 929 | PROSITE-ProRule annotation | ||
Disulfide bondi | 923 ↔ 938 | PROSITE-ProRule annotation | ||
Glycosylationi | 926 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 940 ↔ 951 | PROSITE-ProRule annotation | ||
Disulfide bondi | 976 ↔ 990 | |||
Disulfide bondi | 984 ↔ 1001 | |||
Disulfide bondi | 1003 ↔ 1012 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P01133 |
MassIVEi | P01133 |
PaxDbi | P01133 |
PeptideAtlasi | P01133 |
PRIDEi | P01133 |
ProteomicsDBi | 12632 [P01133-2] 18615 51330 [P01133-1] 51331 [P01133-2] |
PTM databases
GlyConnecti | 709, 2 N-Linked glycans (1 site) |
GlyGeni | P01133, 13 sites, 2 O-linked glycans (4 sites) |
iPTMneti | P01133 |
PhosphoSitePlusi | P01133 |
UniCarbKBi | P01133 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000138798, Expressed in renal medulla and 170 other tissues |
ExpressionAtlasi | P01133, baseline and differential |
Genevisiblei | P01133, HS |
Organism-specific databases
HPAi | ENSG00000138798, Group enriched (kidney, pancreas, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with EGFR and promotes EGFR dimerization.
Interacts with RHBDF2 (By similarity).
Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).
By similarity5 PublicationsBinary interactionsi
Hide detailsP01133
With | #Exp. | IntAct |
---|---|---|
EGFR [P00533] | 29 | EBI-640857,EBI-297353 |
MGST1 [P10620] | 3 | EBI-640857,EBI-2691601 |
Egfr [Q01279] from Mus musculus. | 3 | EBI-640857,EBI-6296235 |
Epidermal growth factor (PRO_0000007541)
With | #Exp. | IntAct |
---|---|---|
P28300 (PRO_0000018520) | 2 | EBI-9076336,EBI-20724846 |
GO - Molecular functioni
- epidermal growth factor receptor binding Source: UniProtKB
- growth factor activity Source: HGNC-UCL
- Ras guanyl-nucleotide exchange factor activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108270, 20 interactors |
DIPi | DIP-5767N |
IntActi | P01133, 13 interactors |
MINTi | P01133 |
STRINGi | 9606.ENSP00000265171 |
Chemistry databases
BindingDBi | P01133 |
Miscellaneous databases
RNActi | P01133, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P01133 |
SMRi | P01133 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01133 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 86 – 127 | LDL-receptor class B 1Add BLAST | 42 | |
Repeati | 128 – 169 | LDL-receptor class B 2Add BLAST | 42 | |
Repeati | 170 – 211 | LDL-receptor class B 3Add BLAST | 42 | |
Repeati | 212 – 258 | LDL-receptor class B 4Add BLAST | 47 | |
Domaini | 314 – 355 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 356 – 396 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 397 – 437 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 435 – 477 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 483 – 523 | LDL-receptor class B 5Add BLAST | 41 | |
Repeati | 524 – 566 | LDL-receptor class B 6Add BLAST | 43 | |
Repeati | 567 – 609 | LDL-receptor class B 7Add BLAST | 43 | |
Repeati | 610 – 653 | LDL-receptor class B 8Add BLAST | 44 | |
Repeati | 654 – 696 | LDL-receptor class B 9Add BLAST | 43 | |
Domaini | 741 – 781 | EGF-like 5PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 831 – 869 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 870 – 911 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 912 – 952 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 972 – 1013 | EGF-like 9PROSITE-ProRule annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 801 – 807 | O-glycosylated at one site | 7 |
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000158366 |
HOGENOMi | CLU_007857_0_0_1 |
InParanoidi | P01133 |
OMAi | CSHGCVL |
OrthoDBi | 1174178at2759 |
PhylomeDBi | P01133 |
TreeFami | TF315253 |
Family and domain databases
Gene3Di | 2.120.10.30, 2 hits |
IDEALi | IID00263 |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR000033, LDLR_classB_rpt IPR016317, Pro-epidermal_GF |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF07645, EGF_CA, 3 hits PF00058, Ldl_recept_b, 4 hits |
PIRSFi | PIRSF001778, Pro-epidermal_growth_factor, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 9 hits SM00179, EGF_CA, 5 hits SM00135, LY, 9 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 3 hits PS00022, EGF_1, 1 hit PS01186, EGF_2, 7 hits PS50026, EGF_3, 5 hits PS01187, EGF_CA, 3 hits PS51120, LDLRB, 9 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLTLIILLP VVSKFSFVSL SAPQHWSCPE GTLAGNGNST CVGPAPFLIF
60 70 80 90 100
SHGNSIFRID TEGTNYEQLV VDAGVSVIMD FHYNEKRIYW VDLERQLLQR
110 120 130 140 150
VFLNGSRQER VCNIEKNVSG MAINWINEEV IWSNQQEGII TVTDMKGNNS
160 170 180 190 200
HILLSALKYP ANVAVDPVER FIFWSSEVAG SLYRADLDGV GVKALLETSE
210 220 230 240 250
KITAVSLDVL DKRLFWIQYN REGSNSLICS CDYDGGSVHI SKHPTQHNLF
260 270 280 290 300
AMSLFGDRIF YSTWKMKTIW IANKHTGKDM VRINLHSSFV PLGELKVVHP
310 320 330 340 350
LAQPKAEDDT WEPEQKLCKL RKGNCSSTVC GQDLQSHLCM CAEGYALSRD
360 370 380 390 400
RKYCEDVNEC AFWNHGCTLG CKNTPGSYYC TCPVGFVLLP DGKRCHQLVS
410 420 430 440 450
CPRNVSECSH DCVLTSEGPL CFCPEGSVLE RDGKTCSGCS SPDNGGCSQL
460 470 480 490 500
CVPLSPVSWE CDCFPGYDLQ LDEKSCAASG PQPFLLFANS QDIRHMHFDG
510 520 530 540 550
TDYGTLLSQQ MGMVYALDHD PVENKIYFAH TALKWIERAN MDGSQRERLI
560 570 580 590 600
EEGVDVPEGL AVDWIGRRFY WTDRGKSLIG RSDLNGKRSK IITKENISQP
610 620 630 640 650
RGIAVHPMAK RLFWTDTGIN PRIESSSLQG LGRLVIASSD LIWPSGITID
660 670 680 690 700
FLTDKLYWCD AKQSVIEMAN LDGSKRRRLT QNDVGHPFAV AVFEDYVWFS
710 720 730 740 750
DWAMPSVMRV NKRTGKDRVR LQGSMLKPSS LVVVHPLAKP GADPCLYQNG
760 770 780 790 800
GCEHICKKRL GTAWCSCREG FMKASDGKTC LALDGHQLLA GGEVDLKNQV
810 820 830 840 850
TPLDILSKTR VSEDNITESQ HMLVAEIMVS DQDDCAPVGC SMYARCISEG
860 870 880 890 900
EDATCQCLKG FAGDGKLCSD IDECEMGVPV CPPASSKCIN TEGGYVCRCS
910 920 930 940 950
EGYQGDGIHC LDIDECQLGE HSCGENASCT NTEGGYTCMC AGRLSEPGLI
960 970 980 990 1000
CPDSTPPPHL REDDHHYSVR NSDSECPLSH DGYCLHDGVC MYIEALDKYA
1010 1020 1030 1040 1050
CNCVVGYIGE RCQYRDLKWW ELRHAGHGQQ QKVIVVAVCV VVLVMLLLLS
1060 1070 1080 1090 1100
LWGAHYYRTQ KLLSKNPKNP YEESSRDVRS RRPADTEDGM SSCPQPWFVV
1110 1120 1130 1140 1150
IKEHQDLKNG GQPVAGEDGQ AADGSMQPTS WRQEPQLCGM GTEQGCWIPV
1160 1170 1180 1190 1200
SSDKGSCPQV MERSFHMPSY GTQTLEGGVE KPHSLLSANP LWQQRALDPP
HQMELTQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494C018 | A0A494C018_HUMAN | Pro-epidermal growth factor | EGF | 1,010 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 302 | A → T in BAG61319 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020161 | 16 | S → R1 PublicationCorresponds to variant dbSNP:rs11568849EnsemblClinVar. | 1 | |
Natural variantiVAR_033825 | 151 | H → Y. Corresponds to variant dbSNP:rs9991664EnsemblClinVar. | 1 | |
Natural variantiVAR_020968 | 257 | D → H1 PublicationCorresponds to variant dbSNP:rs11568911EnsemblClinVar. | 1 | |
Natural variantiVAR_033826 | 292 | L → H. Corresponds to variant dbSNP:rs35191533EnsemblClinVar. | 1 | |
Natural variantiVAR_020162 | 431 | R → K1 PublicationCorresponds to variant dbSNP:rs11568943EnsemblClinVar. | 1 | |
Natural variantiVAR_020969 | 638 | S → R1 PublicationCorresponds to variant dbSNP:rs11568992EnsemblClinVar. | 1 | |
Natural variantiVAR_002275 | 708 | M → I1 PublicationCorresponds to variant dbSNP:rs2237051EnsemblClinVar. | 1 | |
Natural variantiVAR_020163 | 723 | G → R. Corresponds to variant dbSNP:rs6413481Ensembl. | 1 | |
Natural variantiVAR_020164 | 784 | D → V1 PublicationCorresponds to variant dbSNP:rs11569017EnsemblClinVar. | 1 | |
Natural variantiVAR_020165 | 842 | M → T1 PublicationCorresponds to variant dbSNP:rs11569046EnsemblClinVar. | 1 | |
Natural variantiVAR_020970 | 920 | E → V2 PublicationsCorresponds to variant dbSNP:rs4698803EnsemblClinVar. | 1 | |
Natural variantiVAR_020971 | 981 | D → E1 PublicationCorresponds to variant dbSNP:rs11569086Ensembl. | 1 | |
Natural variantiVAR_020166 | 1043 | L → F1 PublicationCorresponds to variant dbSNP:rs11569098EnsemblClinVar. | 1 | |
Natural variantiVAR_039474 | 1070 | P → L in HOMG4; affects basolateral sorting of pro-EGF preventing the hormone to stimulate EGFR; lack of TRPM6 activation. 1 PublicationCorresponds to variant dbSNP:rs121434567EnsemblClinVar. | 1 | |
Natural variantiVAR_020972 | 1084 | A → G1 PublicationCorresponds to variant dbSNP:rs11569111EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041586 | 314 – 355 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_047190 | 912 – 952 | Missing in isoform 3. CuratedAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04571 mRNA Translation: CAA28240.1 AY506357 Genomic DNA Translation: AAR84237.1 Sequence problems. AK299306 mRNA Translation: BAG61319.1 AC004050 Genomic DNA No translation available. AC005509 Genomic DNA No translation available. BC093731 mRNA Translation: AAH93731.1 BC113461 mRNA Translation: AAI13462.1 |
CCDSi | CCDS3689.1 [P01133-1] CCDS54794.1 [P01133-3] CCDS54795.1 [P01133-2] |
PIRi | A25531, EGHU |
RefSeqi | NP_001171601.1, NM_001178130.2 [P01133-3] NP_001171602.1, NM_001178131.2 [P01133-2] NP_001954.2, NM_001963.5 [P01133-1] |
Genome annotation databases
Ensembli | ENST00000265171; ENSP00000265171; ENSG00000138798 [P01133-1] ENST00000503392; ENSP00000421384; ENSG00000138798 [P01133-3] ENST00000509793; ENSP00000424316; ENSG00000138798 [P01133-2] |
GeneIDi | 1950 |
KEGGi | hsa:1950 |
UCSCi | uc003hzy.5, human [P01133-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Epidermal growth factor entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04571 mRNA Translation: CAA28240.1 AY506357 Genomic DNA Translation: AAR84237.1 Sequence problems. AK299306 mRNA Translation: BAG61319.1 AC004050 Genomic DNA No translation available. AC005509 Genomic DNA No translation available. BC093731 mRNA Translation: AAH93731.1 BC113461 mRNA Translation: AAI13462.1 |
CCDSi | CCDS3689.1 [P01133-1] CCDS54794.1 [P01133-3] CCDS54795.1 [P01133-2] |
PIRi | A25531, EGHU |
RefSeqi | NP_001171601.1, NM_001178130.2 [P01133-3] NP_001171602.1, NM_001178131.2 [P01133-2] NP_001954.2, NM_001963.5 [P01133-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IVO | X-ray | 3.30 | C/D | 971-1023 | [»] | |
1JL9 | X-ray | 3.00 | A/B | 971-1021 | [»] | |
1NQL | X-ray | 2.80 | B | 971-1023 | [»] | |
1P9J | NMR | - | A | 976-1022 | [»] | |
2KV4 | NMR | - | A | 971-1023 | [»] | |
3NJP | X-ray | 3.30 | C/D | 975-1021 | [»] | |
BMRBi | P01133 | |||||
SMRi | P01133 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108270, 20 interactors |
DIPi | DIP-5767N |
IntActi | P01133, 13 interactors |
MINTi | P01133 |
STRINGi | 9606.ENSP00000265171 |
Chemistry databases
BindingDBi | P01133 |
ChEMBLi | CHEMBL5734 |
DrugBanki | DB04454, Alpha-Aminobutyric Acid DB08862, Cholecystokinin DB00364, Sucralfate DB11973, Tesevatinib |
PTM databases
GlyConnecti | 709, 2 N-Linked glycans (1 site) |
GlyGeni | P01133, 13 sites, 2 O-linked glycans (4 sites) |
iPTMneti | P01133 |
PhosphoSitePlusi | P01133 |
UniCarbKBi | P01133 |
Polymorphism and mutation databases
BioMutai | EGF |
DMDMi | 251757262 |
Proteomic databases
jPOSTi | P01133 |
MassIVEi | P01133 |
PaxDbi | P01133 |
PeptideAtlasi | P01133 |
PRIDEi | P01133 |
ProteomicsDBi | 12632 [P01133-2] 18615 51330 [P01133-1] 51331 [P01133-2] |
Protocols and materials databases
Antibodypediai | 4510, 1360 antibodies |
Genome annotation databases
Ensembli | ENST00000265171; ENSP00000265171; ENSG00000138798 [P01133-1] ENST00000503392; ENSP00000421384; ENSG00000138798 [P01133-3] ENST00000509793; ENSP00000424316; ENSG00000138798 [P01133-2] |
GeneIDi | 1950 |
KEGGi | hsa:1950 |
UCSCi | uc003hzy.5, human [P01133-1] |
Organism-specific databases
CTDi | 1950 |
DisGeNETi | 1950 |
EuPathDBi | HostDB:ENSG00000138798.11 |
GeneCardsi | EGF |
HGNCi | HGNC:3229, EGF |
HPAi | ENSG00000138798, Group enriched (kidney, pancreas, skeletal muscle) |
MalaCardsi | EGF |
MIMi | 131530, gene 611718, phenotype |
neXtProti | NX_P01133 |
OpenTargetsi | ENSG00000138798 |
Orphaneti | 210159, Adult hepatocellular carcinoma 34527, Familial primary hypomagnesemia with normocalciuria and normocalcemia |
PharmGKBi | PA27664 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000158366 |
HOGENOMi | CLU_007857_0_0_1 |
InParanoidi | P01133 |
OMAi | CSHGCVL |
OrthoDBi | 1174178at2759 |
PhylomeDBi | P01133 |
TreeFami | TF315253 |
Enzyme and pathway databases
PathwayCommonsi | P01133 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1227986, Signaling by ERBB2 R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236394, Signaling by ERBB4 R-HSA-1250196, SHC1 events in ERBB2 signaling R-HSA-1251932, PLCG1 events in ERBB2 signaling R-HSA-1257604, PIP3 activates AKT signaling R-HSA-177929, Signaling by EGFR R-HSA-179812, GRB2 events in EGFR signaling R-HSA-180292, GAB1 signalosome R-HSA-180336, SHC1 events in EGFR signaling R-HSA-182971, EGFR downregulation R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-1963642, PI3K events in ERBB2 signaling R-HSA-212718, EGFR interacts with phospholipase C-gamma R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5637810, Constitutive Signaling by EGFRvIII R-HSA-5638303, Inhibition of Signaling by Overexpressed EGFR R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785631, ERBB2 Regulates Cell Motility R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8847993, ERBB2 Activates PTK6 Signaling R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8863795, Downregulation of ERBB2 signaling R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9664565, Signaling by ERBB2 KD Mutants R-HSA-9665348, Signaling by ERBB2 ECD mutants R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants |
SignaLinki | P01133 |
SIGNORi | P01133 |
Miscellaneous databases
BioGRID-ORCSi | 1950, 7 hits in 846 CRISPR screens |
ChiTaRSi | EGF, human |
EvolutionaryTracei | P01133 |
GeneWikii | Epidermal_growth_factor |
GenomeRNAii | 1950 |
Pharosi | P01133, Tbio |
PROi | PR:P01133 |
RNActi | P01133, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138798, Expressed in renal medulla and 170 other tissues |
ExpressionAtlasi | P01133, baseline and differential |
Genevisiblei | P01133, HS |
Family and domain databases
Gene3Di | 2.120.10.30, 2 hits |
IDEALi | IID00263 |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR000033, LDLR_classB_rpt IPR016317, Pro-epidermal_GF |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF07645, EGF_CA, 3 hits PF00058, Ldl_recept_b, 4 hits |
PIRSFi | PIRSF001778, Pro-epidermal_growth_factor, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 9 hits SM00179, EGF_CA, 5 hits SM00135, LY, 9 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 3 hits PS00022, EGF_1, 1 hit PS01186, EGF_2, 7 hits PS50026, EGF_3, 5 hits PS01187, EGF_CA, 3 hits PS51120, LDLRB, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EGF_HUMAN | |
Accessioni | P01133Primary (citable) accession number: P01133 Secondary accession number(s): B4DRK7 Q52LZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 7, 2009 | |
Last modified: | December 2, 2020 | |
This is version 224 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations