UniProtKB - P01131 (LDLR_BOVIN)
Low-density lipoprotein receptor
LDLR
Functioni
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
By similarityGO - Molecular functioni
- amyloid-beta binding Source: Ensembl
- calcium ion binding Source: InterPro
- identical protein binding Source: Ensembl
- low-density lipoprotein particle binding Source: Ensembl
- low-density lipoprotein particle receptor activity Source: Ensembl
- protease binding Source: Ensembl
- very-low-density lipoprotein particle receptor activity Source: Ensembl
GO - Biological processi
- amyloid-beta clearance by cellular catabolic process Source: Ensembl
- artery morphogenesis Source: Ensembl
- cellular response to fatty acid Source: Ensembl
- cellular response to low-density lipoprotein particle stimulus Source: Ensembl
- cholesterol homeostasis Source: Ensembl
- cholesterol import Source: Ensembl
- cholesterol metabolic process Source: UniProtKB-KW
- high-density lipoprotein particle clearance Source: Ensembl
- intestinal cholesterol absorption Source: Ensembl
- lipoprotein catabolic process Source: Ensembl
- long-term memory Source: Ensembl
- low-density lipoprotein particle clearance Source: Ensembl
- negative regulation of amyloid fibril formation Source: Ensembl
- negative regulation of astrocyte activation Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of low-density lipoprotein particle clearance Source: Ensembl
- negative regulation of microglial cell activation Source: Ensembl
- negative regulation of receptor recycling Source: Ensembl
- phagocytosis Source: Ensembl
- phospholipid transport Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of lysosomal protein catabolic process Source: Ensembl
- positive regulation of triglyceride biosynthetic process Source: Ensembl
- receptor-mediated endocytosis involved in cholesterol transport Source: Ensembl
- regulation of cholesterol metabolic process Source: Ensembl
- regulation of phosphatidylcholine catabolic process Source: Ensembl
- response to caloric restriction Source: Ensembl
Keywordsi
Molecular function | Receptor |
Biological process | Cholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Low-density lipoprotein receptorShort name: LDL receptor |
Gene namesi | Name:LDLR |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000012314 |
VGNCi | VGNC:55214, LDLR |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Lysosome
- Lysosome By similarity
Endosome
- Early endosome By similarity
- Late endosome By similarity
Golgi apparatus
- Golgi apparatus By similarity
Other locations
- clathrin-coated pit By similarity
Note: Rapidly endocytosed upon ligand binding.By similarity
Endosome
- early endosome Source: UniProtKB
- late endosome Source: UniProtKB
- multivesicular body Source: AgBase
- sorting endosome Source: Ensembl
Extracellular region or secreted
- low-density lipoprotein particle Source: UniProtKB-KW
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Lysosome
- lysosome Source: UniProtKB
Plasma Membrane
- basolateral plasma membrane Source: Ensembl
- caveola Source: AgBase
- clathrin-coated pit Source: UniProtKB-SubCell
- external side of plasma membrane Source: Ensembl
Other locations
- apical part of cell Source: Ensembl
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- PCSK9-LDLR complex Source: Ensembl
- receptor complex Source: Ensembl
- somatodendritic compartment Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 774 | Extracellular1 PublicationAdd BLAST | 753 | |
Transmembranei | 775 – 795 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 796 – 845 | CytoplasmicBy similarityAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, Coated pit, Endosome, Golgi apparatus, LDL, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000191075 | 22 – 845 | Low-density lipoprotein receptorAdd BLAST | 824 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 39 | PROSITE-ProRule annotation | ||
Disulfide bondi | 34 ↔ 52 | PROSITE-ProRule annotation | ||
Disulfide bondi | 46 ↔ 63 | PROSITE-ProRule annotation | ||
Disulfide bondi | 68 ↔ 82 | PROSITE-ProRule annotation | ||
Disulfide bondi | 75 ↔ 95 | PROSITE-ProRule annotation | ||
Disulfide bondi | 89 ↔ 104 | PROSITE-ProRule annotation | ||
Disulfide bondi | 109 ↔ 121 | PROSITE-ProRule annotation | ||
Disulfide bondi | 116 ↔ 134 | PROSITE-ProRule annotation | ||
Disulfide bondi | 128 ↔ 143 | PROSITE-ProRule annotation | ||
Disulfide bondi | 148 ↔ 160 | PROSITE-ProRule annotation | ||
Disulfide bondi | 155 ↔ 173 | PROSITE-ProRule annotation | ||
Disulfide bondi | 167 ↔ 184 | PROSITE-ProRule annotation | ||
Disulfide bondi | 199 ↔ 211 | PROSITE-ProRule annotation | ||
Disulfide bondi | 206 ↔ 224 | PROSITE-ProRule annotation | ||
Disulfide bondi | 218 ↔ 233 | PROSITE-ProRule annotation | ||
Disulfide bondi | 238 ↔ 250 | PROSITE-ProRule annotation | ||
Disulfide bondi | 245 ↔ 263 | PROSITE-ProRule annotation | ||
Disulfide bondi | 257 ↔ 272 | PROSITE-ProRule annotation | ||
Disulfide bondi | 278 ↔ 291 | PROSITE-ProRule annotation | ||
Disulfide bondi | 286 ↔ 304 | PROSITE-ProRule annotation | ||
Disulfide bondi | 298 ↔ 315 | PROSITE-ProRule annotation | ||
Disulfide bondi | 320 ↔ 331 | PROSITE-ProRule annotation | ||
Disulfide bondi | 327 ↔ 340 | PROSITE-ProRule annotation | ||
Disulfide bondi | 342 ↔ 354 | PROSITE-ProRule annotation | ||
Disulfide bondi | 360 ↔ 370 | PROSITE-ProRule annotation | ||
Disulfide bondi | 366 ↔ 379 | PROSITE-ProRule annotation | ||
Glycosylationi | 659 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
PaxDbi | P01131 |
PRIDEi | P01131 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000012314, Expressed in diaphragm and 97 other tissues |
ExpressionAtlasi | P01131, baseline and differential |
Interactioni
Subunit structurei
Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif.
Interacts (via NPXY motif) with LDLRAP1 (via PID domain).
Interacts with ARRB1.
Interacts with SNX17.
Interacts with the full-length immature form of PCSK9 (via C-terminus).
By similarityGO - Molecular functioni
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016342 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 64 | LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 67 – 105 | LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 108 – 144 | LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 147 – 185 | LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 198 – 234 | LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 237 – 273 | LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 277 – 316 | LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 316 – 355 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 356 – 388 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 441 – 487 | LDL-receptor class B 1PROSITE-ProRule annotationAdd BLAST | 47 | |
Repeati | 488 – 530 | LDL-receptor class B 2PROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 531 – 574 | LDL-receptor class B 3PROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 575 – 619 | LDL-receptor class B 4PROSITE-ProRule annotationAdd BLAST | 45 | |
Repeati | 620 – 660 | LDL-receptor class B 5PROSITE-ProRule annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 712 – 753 | Clustered O-linked oligosaccharidesSequence analysisAdd BLAST | 42 | |
Regioni | 717 – 765 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 796 – 845 | Required for MYLIP-triggered down-regulation of LDLRBy similarityAdd BLAST | 50 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 808 – 813 | NPXY motifBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 717 – 764 | Polar residuesSequence analysisAdd BLAST | 48 |
Domaini
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000161046 |
InParanoidi | P01131 |
OMAi | IMNEAIF |
OrthoDBi | 359795at2759 |
TreeFami | TF351700 |
Family and domain databases
CDDi | cd00112, LDLa, 6 hits |
Gene3Di | 2.120.10.30, 1 hit 4.10.400.10, 6 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR000033, LDLR_classB_rpt IPR002172, LDrepeatLR_classA_rpt |
Pfami | View protein in Pfam PF07645, EGF_CA, 1 hit PF00057, Ldl_recept_a, 7 hits PF00058, Ldl_recept_b, 5 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00179, EGF_CA, 2 hits SM00192, LDLa, 7 hits SM00135, LY, 5 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57424, SSF57424, 6 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS01186, EGF_2, 2 hits PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit PS01209, LDLRA_1, 7 hits PS50068, LDLRA_2, 7 hits PS51120, LDLRB, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MRLAGWGLRW AIALLIAVGE AAVEDNCGRN EFQCQDGKCI SYKWVCDGTA
60 70 80 90 100
ECQDGSDESQ ETCKSVTCKM GDFSCGGRVN RCISGSWRCD GQVDCENGSD
110 120 130 140 150
EEGCSPKTCS QDEFRCNDGK CIAPKFVCDL DLDCLDGSDE ASCPMPTCGP
160 170 180 190 200
ANFQCNSSMC IPQLWACDGD PDCDDGSDEW PKHCGTPHPS GPLQDNNPCS
210 220 230 240 250
ALEFHCGSGE CIHSSWHCDH DPDCKDKSDE ENCAVATCRP DEFQCSDGTC
260 270 280 290 300
IHGSRQCDRE PDCKDLSDEL GCVNVTLCEG PNKFKCQSGE CISLDKVCNS
310 320 330 340 350
VRDCRDWSDE PLKDCGTNEC LDNKGGCSHI CNDLKIGYEC LCPEGFQLVG
360 370 380 390 400
KHRCEDIDEC QNPDTCSQLC VNLEGSYKCE CEEGFRLEPL TKACKAVGTI
410 420 430 440 450
AYLFFTNRHE VRKMTLDRSE YTSLIPNLKN VVALDTEVAS NRIYWSDLSQ
460 470 480 490 500
RKIYSAQIDG APGFSSYDTV IGEDLQAPDG LAVDWIHSNI YWTDSILGTV
510 520 530 540 550
SVADTKGVKR KTLFQEEGSK PRAIVVDPVH GFMYWTDWGA PAEIKKGGLN
560 570 580 590 600
GVDVYSLVTE DIQWPNGITL DLSGGRLYWV DSKLHSISSI DVNGGNRKTV
610 620 630 640 650
LEDKKKLAHP FSLAIFEDKV FWTDVINEAI FSANRLTGSD ISLMAENLLS
660 670 680 690 700
PEDIVLFHNL TQPRGVNWCE RTALRNGGCQ YLCLPAPQIN PRSPKFTCAC
710 720 730 740 750
PDGMLLAKDM RSCLTESESA VTTRGPSTVS STAVGPKRTA SPELTTAESV
760 770 780 790 800
TMSQQGQGDI ASQADTERPG SVGALYIVLP IALLILLAFG TFLLWKNWRL
810 820 830 840
KSINSINFDN PVYQKTTEDE VHICRSQDGY TYPSRQMVSL EDDVA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1NG72 | A0A3Q1NG72_BOVIN | Low-density lipoprotein receptor | LDLR | 804 | Annotation score: | ||
A0A3Q1LYY5 | A0A3Q1LYY5_BOVIN | Low-density lipoprotein receptor | LDLR | 783 | Annotation score: | ||
A0A3Q1NKK1 | A0A3Q1NKK1_BOVIN | Low-density lipoprotein receptor | LDLR | 804 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 760 | I → V in AAA30618 (PubMed:6327078).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DAAA02019482 Genomic DNA No translation available. K01830 mRNA Translation: AAA30618.1 K01429 mRNA Translation: AAA30620.1 M29843 mRNA Translation: AAA30619.1 |
PIRi | A01384, QRBOLD |
RefSeqi | NP_001160002.1, NM_001166530.1 |
Genome annotation databases
Ensembli | ENSBTAT00000016342; ENSBTAP00000016342; ENSBTAG00000012314 |
GeneIDi | 281276 |
KEGGi | bta:281276 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DAAA02019482 Genomic DNA No translation available. K01830 mRNA Translation: AAA30618.1 K01429 mRNA Translation: AAA30620.1 M29843 mRNA Translation: AAA30619.1 |
PIRi | A01384, QRBOLD |
RefSeqi | NP_001160002.1, NM_001166530.1 |
3D structure databases
AlphaFoldDBi | P01131 |
SMRi | P01131 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000016342 |
Proteomic databases
PaxDbi | P01131 |
PRIDEi | P01131 |
Genome annotation databases
Ensembli | ENSBTAT00000016342; ENSBTAP00000016342; ENSBTAG00000012314 |
GeneIDi | 281276 |
KEGGi | bta:281276 |
Organism-specific databases
CTDi | 3949 |
VEuPathDBi | HostDB:ENSBTAG00000012314 |
VGNCi | VGNC:55214, LDLR |
Phylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000161046 |
InParanoidi | P01131 |
OMAi | IMNEAIF |
OrthoDBi | 359795at2759 |
TreeFami | TF351700 |
Gene expression databases
Bgeei | ENSBTAG00000012314, Expressed in diaphragm and 97 other tissues |
ExpressionAtlasi | P01131, baseline and differential |
Family and domain databases
CDDi | cd00112, LDLa, 6 hits |
Gene3Di | 2.120.10.30, 1 hit 4.10.400.10, 6 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR000033, LDLR_classB_rpt IPR002172, LDrepeatLR_classA_rpt |
Pfami | View protein in Pfam PF07645, EGF_CA, 1 hit PF00057, Ldl_recept_a, 7 hits PF00058, Ldl_recept_b, 5 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00179, EGF_CA, 2 hits SM00192, LDLa, 7 hits SM00135, LY, 5 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57424, SSF57424, 6 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS01186, EGF_2, 2 hits PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit PS01209, LDLRA_1, 7 hits PS50068, LDLRA_2, 7 hits PS51120, LDLRB, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LDLR_BOVIN | |
Accessioni | P01131Primary (citable) accession number: P01131 Secondary accession number(s): F1MZ58 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 30, 2016 | |
Last modified: | May 25, 2022 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families