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Protein

Platelet-derived growth factor subunit B

Gene

PDGFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei108Involved in receptor binding1
Sitei111Involved in receptor binding1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-186763 Downstream signal transduction
R-HSA-186797 Signaling by PDGF
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P01127

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01127

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet-derived growth factor subunit B
Short name:
PDGF subunit B
Alternative name(s):
PDGF-2
Platelet-derived growth factor B chain
Platelet-derived growth factor beta polypeptide
Proto-oncogene c-Sis
INN: Becaplermin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDGFB
Synonyms:PDGF2, SIS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100311.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8800 PDGFB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
190040 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01127

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Basal ganglia calcification, idiopathic, 5 (IBGC5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
See also OMIM:615483
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0708709L → R in IBGC5; loss of protein expression. 2 Publications1
Natural variantiVAR_070871119L → P in IBGC5; loss of protein expression. 2 PublicationsCorresponds to variant dbSNP:rs397515632EnsemblClinVar.1
A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.1 Publication

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the name Regranex (Ortho-McNeil). Used to promote healing in diabetic neuropathic foot ulcers.

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
5155

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PDGFB

MalaCards human disease database

More...
MalaCardsi
PDGFB
MIMi607907 phenotype
615483 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100311

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1980 Bilateral striopallidodentate calcinosis
31112 Dermatofibrosarcoma protuberans
263662 Familial multiple meningioma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33145

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3108633

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDGFB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
129724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Add BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002337121 – 81Removed in mature formAdd BLAST61
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002337282 – 190Platelet-derived growth factor subunit BAdd BLAST109
PropeptideiPRO_0000023373191 – 241Removed in mature formAdd BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi97 ↔ 1411 Publication
Disulfide bondi124Interchain1 Publication
Disulfide bondi130 ↔ 1781 Publication
Disulfide bondi133Interchain1 Publication
Disulfide bondi134 ↔ 1801 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P01127

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01127

PeptideAtlas

More...
PeptideAtlasi
P01127

PRoteomics IDEntifications database

More...
PRIDEi
P01127

ProteomicsDB human proteome resource

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ProteomicsDBi
12691
51325

Consortium for Top Down Proteomics

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TopDownProteomicsi
P01127-2 [P01127-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
754

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01127

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01127

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01127

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01127

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100311 Expressed in 215 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_PDGFB

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01127 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01127 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011604
CAB018341
HPA011972

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111181, 92 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1875 Platelet-derived growth factor AB complex
CPX-1876 Platelet-derived growth factor BB complex
CPX-2882 PDGF receptor beta - PDGF-BB complex
CPX-2883 PDGF receptor alpha-beta - PDGF-BB complex
CPX-2884 PDGF receptor alpha - PDGF-BB complex
CPX-2885 PDGF receptor alpha - PDGF-AB complex
CPX-2886 PDGF receptor beta - PDGF-AB complex
CPX-2892 PDGF receptor alpha-beta - PDGF-AB complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P01127

Database of interacting proteins

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DIPi
DIP-5737N

Protein interaction database and analysis system

More...
IntActi
P01127, 7 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000330382

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P01127

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PDGX-ray3.00A/B/C82-190[»]
3MJGX-ray2.30A/B21-185[»]
4HQUX-ray2.20A82-190[»]
4HQXX-ray2.30A82-183[»]
4QCIX-ray2.30C/D82-190[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P01127

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01127

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01127

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ45 Eukaryota
ENOG410XWTB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157367

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000286027

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053546

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01127

KEGG Orthology (KO)

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KOi
K17386

Identification of Orthologs from Complete Genome Data

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OMAi
TRTEVFQ

Database of Orthologous Groups

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OrthoDBi
1439735at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01127

TreeFam database of animal gene trees

More...
TreeFami
TF319554

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00135 PDGF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
IPR015583 PDGF_suB

The PANTHER Classification System

More...
PANTHERi
PTHR11633:SF2 PTHR11633:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00141 PDGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P01127-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG
60 70 80 90 100
DPGEEDGAEL DLNMTRSHSG GELESLARGR RSLGSLTIAE PAMIAECKTR
110 120 130 140 150
TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP
160 170 180 190 200
VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT RSPGGSQEQR
210 220 230 240
AKTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG A
Length:241
Mass (Da):27,283
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F9A3474CE203C0B
GO
Isoform 2 (identifier: P01127-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MNRCWALFLSLCCYLRLVSAE → MFIMGL

Show »
Length:226
Mass (Da):25,502
Checksum:i523AC7394E29C0D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9UJN9A9UJN9_HUMAN
Platelet-derived growth factor subu...
PDGFB
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A9UJP0A9UJP0_HUMAN
Platelet-derived growth factor subu...
PDGFB
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101T → E AA sequence (PubMed:6844921).Curated1
Sequence conflicti105E → C AA sequence (PubMed:6844921).Curated1
Sequence conflicti107S → C AA sequence (PubMed:6844921).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0708709L → R in IBGC5; loss of protein expression. 2 Publications1
Natural variantiVAR_01457888I → V. Corresponds to variant dbSNP:rs17565Ensembl.1
Natural variantiVAR_070871119L → P in IBGC5; loss of protein expression. 2 PublicationsCorresponds to variant dbSNP:rs397515632EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449131 – 21MNRCW…LVSAE → MFIMGL in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
K01401
, K01918, J00121, K01398, K01399, K01400 Genomic DNA Translation: AAA60552.1
X02811 mRNA Translation: CAA26579.1
X02744 mRNA Translation: CAA26524.1
M12783 mRNA Translation: AAA60553.1
CR456538 mRNA Translation: CAG30424.1
Z81010 Genomic DNA No translation available.
CR541807 mRNA Translation: CAG46606.1
CH471095 Genomic DNA Translation: EAW60306.1
CH471095 Genomic DNA Translation: EAW60307.1
BC029822 mRNA Translation: AAH29822.1
BC077725 mRNA Translation: AAH77725.1
X83705 mRNA Translation: CAA58679.1
X98706 Genomic DNA Translation: CAA67262.1
K01917
, K01913, K01914, K01915, K01916 Genomic DNA Translation: AAA98793.1
X03702 mRNA Translation: CAA27333.1
X00561 Genomic DNA Translation: CAA25228.1
X00561 Genomic DNA Translation: CAA25229.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13987.1 [P01127-1]
CCDS33650.1 [P01127-2]

Protein sequence database of the Protein Information Resource

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PIRi
A94276 PFHUG2

NCBI Reference Sequences

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RefSeqi
NP_002599.1, NM_002608.3 [P01127-1]
NP_148937.1, NM_033016.3 [P01127-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.1976

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000331163; ENSP00000330382; ENSG00000100311 [P01127-1]
ENST00000381551; ENSP00000370963; ENSG00000100311 [P01127-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5155

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5155

UCSC genome browser

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UCSCi
uc003axe.4 human [P01127-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01401
, K01918, J00121, K01398, K01399, K01400 Genomic DNA Translation: AAA60552.1
X02811 mRNA Translation: CAA26579.1
X02744 mRNA Translation: CAA26524.1
M12783 mRNA Translation: AAA60553.1
CR456538 mRNA Translation: CAG30424.1
Z81010 Genomic DNA No translation available.
CR541807 mRNA Translation: CAG46606.1
CH471095 Genomic DNA Translation: EAW60306.1
CH471095 Genomic DNA Translation: EAW60307.1
BC029822 mRNA Translation: AAH29822.1
BC077725 mRNA Translation: AAH77725.1
X83705 mRNA Translation: CAA58679.1
X98706 Genomic DNA Translation: CAA67262.1
K01917
, K01913, K01914, K01915, K01916 Genomic DNA Translation: AAA98793.1
X03702 mRNA Translation: CAA27333.1
X00561 Genomic DNA Translation: CAA25228.1
X00561 Genomic DNA Translation: CAA25229.1
CCDSiCCDS13987.1 [P01127-1]
CCDS33650.1 [P01127-2]
PIRiA94276 PFHUG2
RefSeqiNP_002599.1, NM_002608.3 [P01127-1]
NP_148937.1, NM_033016.3 [P01127-2]
UniGeneiHs.1976

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PDGX-ray3.00A/B/C82-190[»]
3MJGX-ray2.30A/B21-185[»]
4HQUX-ray2.20A82-190[»]
4HQXX-ray2.30A82-183[»]
4QCIX-ray2.30C/D82-190[»]
ProteinModelPortaliP01127
SMRiP01127
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111181, 92 interactors
ComplexPortaliCPX-1875 Platelet-derived growth factor AB complex
CPX-1876 Platelet-derived growth factor BB complex
CPX-2882 PDGF receptor beta - PDGF-BB complex
CPX-2883 PDGF receptor alpha-beta - PDGF-BB complex
CPX-2884 PDGF receptor alpha - PDGF-BB complex
CPX-2885 PDGF receptor alpha - PDGF-AB complex
CPX-2886 PDGF receptor beta - PDGF-AB complex
CPX-2892 PDGF receptor alpha-beta - PDGF-AB complex
CORUMiP01127
DIPiDIP-5737N
IntActiP01127, 7 interactors
STRINGi9606.ENSP00000330382

Chemistry databases

BindingDBiP01127
ChEMBLiCHEMBL3108633

PTM databases

GlyConnecti754
iPTMnetiP01127
PhosphoSitePlusiP01127
UniCarbKBiP01127

Polymorphism and mutation databases

BioMutaiPDGFB
DMDMi129724

Proteomic databases

jPOSTiP01127
PaxDbiP01127
PeptideAtlasiP01127
PRIDEiP01127
ProteomicsDBi12691
51325
TopDownProteomicsiP01127-2 [P01127-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5155
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331163; ENSP00000330382; ENSG00000100311 [P01127-1]
ENST00000381551; ENSP00000370963; ENSG00000100311 [P01127-2]
GeneIDi5155
KEGGihsa:5155
UCSCiuc003axe.4 human [P01127-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5155
DisGeNETi5155
EuPathDBiHostDB:ENSG00000100311.16

GeneCards: human genes, protein and diseases

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GeneCardsi
PDGFB
GeneReviewsiPDGFB
HGNCiHGNC:8800 PDGFB
HPAiCAB011604
CAB018341
HPA011972
MalaCardsiPDGFB
MIMi190040 gene
607907 phenotype
615483 phenotype
neXtProtiNX_P01127
OpenTargetsiENSG00000100311
Orphaneti1980 Bilateral striopallidodentate calcinosis
31112 Dermatofibrosarcoma protuberans
263662 Familial multiple meningioma
PharmGKBiPA33145

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ45 Eukaryota
ENOG410XWTB LUCA
GeneTreeiENSGT00940000157367
HOGENOMiHOG000286027
HOVERGENiHBG053546
InParanoidiP01127
KOiK17386
OMAiTRTEVFQ
OrthoDBi1439735at2759
PhylomeDBiP01127
TreeFamiTF319554

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-186763 Downstream signal transduction
R-HSA-186797 Signaling by PDGF
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP01127
SIGNORiP01127

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PDGFB human
EvolutionaryTraceiP01127

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PDGFB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5155
PMAP-CutDBiP01127

Protein Ontology

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PROi
PR:P01127

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100311 Expressed in 215 organ(s), highest expression level in placenta
CleanExiHS_PDGFB
ExpressionAtlasiP01127 baseline and differential
GenevisibleiP01127 HS

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
IPR015583 PDGF_suB
PANTHERiPTHR11633:SF2 PTHR11633:SF2, 1 hit
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDGFB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01127
Secondary accession number(s): G3XAG8
, P78431, Q15354, Q6FHE7, Q9UF23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 16, 2019
This is version 224 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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