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Entry version 236 (16 Oct 2019)
Sequence version 1 (21 Jul 1986)
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Protein

GTPase KRas

Gene

KRAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).Curated3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interaction with SOS1 promotes exchange of bound GDP by GTP.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 18GTP2 Publications9
Nucleotide bindingi29 – 35GTP2 Publications7
Nucleotide bindingi59 – 60GTP2 Publications2
Nucleotide bindingi116 – 119GTP2 Publications4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-112412 SOS-mediated signalling
R-HSA-1169092 Activation of RAS in B cells
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-167044 Signalling to RAS
R-HSA-171007 p38MAPK events
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-186763 Downstream signal transduction
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-210993 Tie2 Signaling
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2424491 DAP12 signaling
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-8951936 RUNX3 regulates p14-ARF
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9607240 FLT3 Signaling
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P01116

SIGNOR Signaling Network Open Resource

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SIGNORi
P01116

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTPase KRas
Alternative name(s):
K-Ras 2
Ki-Ras
c-K-ras
c-Ki-ras
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRAS
Synonyms:KRAS2, RASK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6407 KRAS

Online Mendelian Inheritance in Man (OMIM)

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MIMi
190070 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P01116

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukemia, acute myelogenous (AML)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03460110G → GG in AML; expression in 3T3 cell causes cellular transformation; expression in COS cells activates the Ras-MAPK signaling pathway; lower GTPase activity; faster GDP dissociation rate. 1 Publication1
Leukemia, juvenile myelomonocytic (JMML)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01602612G → D in GASC and JMML; also found in pancreatic carcinoma and lung carcinoma; somatic mutation. 5 PublicationsCorresponds to variant dbSNP:rs121913529EnsemblClinVar.1
Natural variantiVAR_01602812G → S in GASC and JMML; also found in lung carcinoma; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs121913530EnsemblClinVar.1
Natural variantiVAR_01602913G → D in GASC and JMML; also found in a breast carcinoma cell line; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs112445441EnsemblClinVar.1
Noonan syndrome 3 (NS3)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0651445K → E in NS3. 1 PublicationCorresponds to variant dbSNP:rs193929331EnsemblClinVar.1
Natural variantiVAR_02610914V → I in NS3; affects activity and impairs responsiveness to GTPase activating proteins; characterized by a strong increase of both intrinsic and guanine nucleotide exchanged factor-catalyzed nucleotide exchange leading to an increased level of the activated state. 1 PublicationCorresponds to variant dbSNP:rs104894365EnsemblClinVar.1
Natural variantiVAR_06485122Q → R in NS3; impairs GTPase-activating protein stimulated GTP hydrolysis with unaffected intrinsic functions and a virtually functional effector interaction. Corresponds to variant dbSNP:rs727503110EnsemblClinVar.1
Natural variantiVAR_06485234P → L in NS3; characterized by a defective GTPase-activating protein sensitivity and a strongly reduced interaction with effectors. Corresponds to variant dbSNP:rs104894366EnsemblClinVar.1
Natural variantiVAR_06485334P → Q in NS3. 1
Natural variantiVAR_06485436I → M in NS3. Corresponds to variant dbSNP:rs727503109EnsemblClinVar.1
Natural variantiVAR_02611158T → I in NS3; affects activity and impairs responsiveness to GTPase activating proteins; exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein. 2 PublicationsCorresponds to variant dbSNP:rs104894364EnsemblClinVar.1
Natural variantiVAR_06514660G → S in NS3. 1 PublicationCorresponds to variant dbSNP:rs104894359EnsemblClinVar.1
Isoform 2B (identifier: P01116-2)
Natural varianti152V → G in NS3. 1
Natural varianti153D → V in CFC2 and NS3, exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein. 1
Gastric cancer (GASC)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0648495K → N in GASC; found also in a patient with Costello syndrome; exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein. 1 PublicationCorresponds to variant dbSNP:rs104894361EnsemblClinVar.1
Natural variantiVAR_01602612G → D in GASC and JMML; also found in pancreatic carcinoma and lung carcinoma; somatic mutation. 5 PublicationsCorresponds to variant dbSNP:rs121913529EnsemblClinVar.1
Natural variantiVAR_01602812G → S in GASC and JMML; also found in lung carcinoma; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs121913530EnsemblClinVar.1
Natural variantiVAR_00684012G → V in GASC; also found in lung carcinoma, pancreatic carcinoma and colon cancer; somatic mutation; it is constitutively activated and stimulates transcription activation of tumor suppressor genes in non-transformed fibroblasts. 8 PublicationsCorresponds to variant dbSNP:rs121913529EnsemblClinVar.1
Natural variantiVAR_01602913G → D in GASC and JMML; also found in a breast carcinoma cell line; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs112445441EnsemblClinVar.1
Natural variantiVAR_01603059A → T in GASC; also found in bladder cancer; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs121913528EnsemblClinVar.1
Defects in KRAS are a cause of pylocytic astrocytoma (PA). Pylocytic astrocytomas are neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors.1 Publication
Cardiofaciocutaneous syndrome 2 (CFC2)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. CFC2 patients often do not have the skin abnormalities, such as ichthyosis, hyperkeratosis, and hemangioma observed in CFC1.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06485022Q → E in CFC2; exhibits an increase in intrinsic and guanine nucleotide exchange factor catalyzed nucleotide exchange in combination with an impaired GTPase-activating protein-stimulated GTP hydrolysis but functional in interaction with effectors. 2 Publications1
Natural variantiVAR_02611034P → R in CFC2; characterized by a defective GTPase-activating protein sensitivity and a strongly reduced interaction with effectors. 2 PublicationsCorresponds to variant dbSNP:rs104894366EnsemblClinVar.1
Natural variantiVAR_02611260G → R in CFC2; characterized by a defective GTPase-activating protein sensitivity and a strongly reduced interaction with effectors. 2 PublicationsCorresponds to variant dbSNP:rs104894359EnsemblClinVar.1
Natural variantiVAR_06978471Y → H in CFC2. 1 PublicationCorresponds to variant dbSNP:rs387907205EnsemblClinVar.1
Natural variantiVAR_069785147K → E in CFC2. 1 PublicationCorresponds to variant dbSNP:rs387907206EnsemblClinVar.1
Isoform 2B (identifier: P01116-2)
Natural varianti153D → V in CFC2 and NS3, exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein. 1
KRAS mutations are involved in cancer development.9 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi164R → A: Loss of GTP-binding activity. 1

Keywords - Diseasei

Cardiomyopathy, Deafness, Disease mutation, Ectodermal dysplasia, Mental retardation, Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
3845

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
KRAS

MalaCards human disease database

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MalaCardsi
KRAS
MIMi601626 phenotype
607785 phenotype
609942 phenotype
613659 phenotype
615278 phenotype

Open Targets

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OpenTargetsi
ENSG00000133703

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
1340 Cardiofaciocutaneous syndrome
146 Differentiated thyroid carcinoma
2396 Encephalocraniocutaneous lipomatosis
1333 Familial pancreatic carcinoma
86834 Juvenile myelomonocytic leukemia
2612 Linear nevus sebaceus syndrome
144 Lynch syndrome
648 Noonan syndrome
251615 Pilomyxoid astrocytoma
268114 RAS-associated autoimmune leukoproliferative disease
357194 Selection of therapeutic option in colorectal cancer
357191 Selection of therapeutic option in non-small cell lung carcinoma
3339 Toriello-Lacassie-Droste syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30196

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P01116

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2189121

Drug and drug target database

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DrugBanki
DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
DB07780 Farnesyl diphosphate

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2824

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KRAS

Domain mapping of disease mutations (DMDM)

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DMDMi
131875

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000826411 – 186GTPase KRasAdd BLAST186
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternate1 Publication
ChainiPRO_00003264802 – 186GTPase KRas, N-terminally processedAdd BLAST185
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000281291187 – 189Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine; in GTPase KRas; alternate1 Publication1
Modified residuei2N-acetylthreonine; in GTPase KRas, N-terminally processed1 Publication1
Modified residuei104N6-acetyllysine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi180S-palmitoyl cysteineBy similarity1
Modified residuei186Cysteine methyl esterCombined sources1 Publication1
Lipidationi186S-farnesyl cysteineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).2 Publications
Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Methylation, Palmitate, Prenylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P01116

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P01116

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P01116

MaxQB - The MaxQuant DataBase

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MaxQBi
P01116

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P01116

PeptideAtlas

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PeptideAtlasi
P01116

PRoteomics IDEntifications database

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PRIDEi
P01116

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51323 [P01116-1]
51324 [P01116-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P01116-2 [P01116-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P01116

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P01116

SwissPalm database of S-palmitoylation events

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SwissPalmi
P01116

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000133703 Expressed in 243 organ(s), highest expression level in colon

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P01116 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P01116 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA049830

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PHLPP.

Interacts (active GTP-bound form preferentially) with RGS14 (By similarity).

Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (PubMed:23698361).

Interacts with SOS1 (PubMed:22431598).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110043, 968 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P01116

Database of interacting proteins

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DIPi
DIP-33951N

Protein interaction database and analysis system

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IntActi
P01116, 72 interactors

Molecular INTeraction database

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MINTi
P01116

STRING: functional protein association networks

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STRINGi
9606.ENSP00000256078

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P01116

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01116

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P01116

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni166 – 185Hypervariable regionAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi32 – 40Effector region9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0395 Eukaryota
COG1100 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233973

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01116

KEGG Orthology (KO)

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KOi
K07827

Identification of Orthologs from Complete Genome Data

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OMAi
PTVENCY

Database of Orthologous Groups

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OrthoDBi
1586678at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P01116

TreeFam database of animal gene trees

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TreeFami
TF312796

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type

The PANTHER Classification System

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PANTHERi
PTHR24070 PTHR24070, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00071 Ras, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00231 small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51421 RAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms differ in the C-terminal region which is encoded by two alternative exons (IVA and IVB).

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2A (identifier: P01116-1) [UniParc]FASTAAdd to basket
Also known as: K-Ras4A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI
110 120 130 140 150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QDLARSYGIP FIETSAKTRQ
160 170 180
RVEDAFYTLV REIRQYRLKK ISKEEKTPGC VKIKKCIIM
Length:189
Mass (Da):21,656
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i973547B2E11C2C81
GO
Isoform 2B (identifier: P01116-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: K-Ras4B

The sequence of this isoform differs from the canonical sequence as follows:
     151-153: RVE → GVD
     165-189: QYRLKKISKEEKTPGCVKIKKCIIM → KHKEKMSKDGKKKKKKSKTKCVIM

Show »
Length:188
Mass (Da):21,425
Checksum:iB1B6D189BB259861
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5T7G3V5T7_HUMAN
GTPase KRas
KRAS
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4K2G3V4K2_HUMAN
GTPase KRas
KRAS
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0651445K → E in NS3. 1 PublicationCorresponds to variant dbSNP:rs193929331EnsemblClinVar.1
Natural variantiVAR_0648495K → N in GASC; found also in a patient with Costello syndrome; exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein. 1 PublicationCorresponds to variant dbSNP:rs104894361EnsemblClinVar.1
Natural variantiVAR_03460110G → GG in AML; expression in 3T3 cell causes cellular transformation; expression in COS cells activates the Ras-MAPK signaling pathway; lower GTPase activity; faster GDP dissociation rate. 1 Publication1
Natural variantiVAR_03630512G → A in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913529EnsemblClinVar.1
Natural variantiVAR_00683912G → C in lung carcinoma; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs121913530EnsemblClinVar.1
Natural variantiVAR_01602612G → D in GASC and JMML; also found in pancreatic carcinoma and lung carcinoma; somatic mutation. 5 PublicationsCorresponds to variant dbSNP:rs121913529EnsemblClinVar.1
Natural variantiVAR_01602712G → R in lung cancer and bladder cancer; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913530EnsemblClinVar.1
Natural variantiVAR_01602812G → S in GASC and JMML; also found in lung carcinoma; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs121913530EnsemblClinVar.1
Natural variantiVAR_00684012G → V in GASC; also found in lung carcinoma, pancreatic carcinoma and colon cancer; somatic mutation; it is constitutively activated and stimulates transcription activation of tumor suppressor genes in non-transformed fibroblasts. 8 PublicationsCorresponds to variant dbSNP:rs121913529EnsemblClinVar.1
Natural variantiVAR_01602913G → D in GASC and JMML; also found in a breast carcinoma cell line; somatic mutation. 4 PublicationsCorresponds to variant dbSNP:rs112445441EnsemblClinVar.1
Natural variantiVAR_06514513G → R in pylocytic astrocytoma; somatic mutation; increase activation of the Ras pathway. 1 PublicationCorresponds to variant dbSNP:rs121913535EnsemblClinVar.1
Natural variantiVAR_02610914V → I in NS3; affects activity and impairs responsiveness to GTPase activating proteins; characterized by a strong increase of both intrinsic and guanine nucleotide exchanged factor-catalyzed nucleotide exchange leading to an increased level of the activated state. 1 PublicationCorresponds to variant dbSNP:rs104894365EnsemblClinVar.1
Natural variantiVAR_06485022Q → E in CFC2; exhibits an increase in intrinsic and guanine nucleotide exchange factor catalyzed nucleotide exchange in combination with an impaired GTPase-activating protein-stimulated GTP hydrolysis but functional in interaction with effectors. 2 Publications1
Natural variantiVAR_06485122Q → R in NS3; impairs GTPase-activating protein stimulated GTP hydrolysis with unaffected intrinsic functions and a virtually functional effector interaction. Corresponds to variant dbSNP:rs727503110EnsemblClinVar.1
Natural variantiVAR_06485234P → L in NS3; characterized by a defective GTPase-activating protein sensitivity and a strongly reduced interaction with effectors. Corresponds to variant dbSNP:rs104894366EnsemblClinVar.1
Natural variantiVAR_06485334P → Q in NS3. 1
Natural variantiVAR_02611034P → R in CFC2; characterized by a defective GTPase-activating protein sensitivity and a strongly reduced interaction with effectors. 2 PublicationsCorresponds to variant dbSNP:rs104894366EnsemblClinVar.1
Natural variantiVAR_06485436I → M in NS3. Corresponds to variant dbSNP:rs727503109EnsemblClinVar.1
Natural variantiVAR_02611158T → I in NS3; affects activity and impairs responsiveness to GTPase activating proteins; exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein. 2 PublicationsCorresponds to variant dbSNP:rs104894364EnsemblClinVar.1
Natural variantiVAR_01603059A → T in GASC; also found in bladder cancer; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs121913528EnsemblClinVar.1
Natural variantiVAR_02611260G → R in CFC2; characterized by a defective GTPase-activating protein sensitivity and a strongly reduced interaction with effectors. 2 PublicationsCorresponds to variant dbSNP:rs104894359EnsemblClinVar.1
Natural variantiVAR_06514660G → S in NS3. 1 PublicationCorresponds to variant dbSNP:rs104894359EnsemblClinVar.1
Natural variantiVAR_00684161Q → H in lung carcinoma. 3 PublicationsCorresponds to variant dbSNP:rs17851045EnsemblClinVar.1
Natural variantiVAR_03630661Q → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913240EnsemblClinVar.1
Natural variantiVAR_06978471Y → H in CFC2. 1 PublicationCorresponds to variant dbSNP:rs387907205EnsemblClinVar.1
Natural variantiVAR_036307117K → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs770248150EnsemblClinVar.1
Natural variantiVAR_036308146A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913527EnsemblClinVar.1
Natural variantiVAR_069785147K → E in CFC2. 1 PublicationCorresponds to variant dbSNP:rs387907206EnsemblClinVar.1
Isoform 2B (identifier: P01116-2)
Natural varianti152V → G in NS3. 1
Natural varianti153D → V in CFC2 and NS3, exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein. 1
Natural varianti156F → I in NS3/CFC2. 1
Natural varianti156F → L Found in a patient with Costello syndrome, exhibits an increase in intrinsic and guanine nucleotide exchange factor catalyzed nucleotide exchange in combination with an impaired GTPase-activating protein-stimulated GTP hydrolysis but functional in interaction with effectors. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011140151 – 153RVE → GVD in isoform 2B. 5 Publications3
Alternative sequenceiVSP_011141165 – 189QYRLK…KCIIM → KHKEKMSKDGKKKKKKSKTK CVIM in isoform 2B. 5 PublicationsAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L00049
, L00045, L00046, L00047 Genomic DNA Translation: AAB59444.1
L00048
, L00045, L00046, L00047 Genomic DNA Translation: AAB59445.1
M54968 mRNA Translation: AAB41942.1
AF493917 mRNA Translation: AAM12631.1
BT007153 mRNA Translation: AAP35817.1
AK292510 mRNA Translation: BAF85199.1
CH471094 Genomic DNA Translation: EAW96511.1
CH471094 Genomic DNA Translation: EAW96512.1
EU332849 Genomic DNA Translation: ABY87538.1
BC013572 mRNA Translation: AAH13572.1
K01519 Genomic DNA No translation available.
K01520 Genomic DNA No translation available.
M25876 Genomic DNA Translation: AAA35683.1
M34904 Genomic DNA Translation: AAA36149.1
M30539 Genomic DNA Translation: AAA36557.1
X01669 Genomic DNA Translation: CAA25828.1
X02825 Genomic DNA Translation: CAA26593.1
K03210, K03209 Genomic DNA Translation: AAA36554.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8702.1 [P01116-2]
CCDS8703.1 [P01116-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A93311 TVHUK
B93311 TVHU2K

NCBI Reference Sequences

More...
RefSeqi
NP_004976.2, NM_004985.4 [P01116-2]
NP_203524.1, NM_033360.3 [P01116-1]
XP_006719132.1, XM_006719069.3
XP_011518955.1, XM_011520653.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000256078; ENSP00000256078; ENSG00000133703 [P01116-1]
ENST00000311936; ENSP00000308495; ENSG00000133703 [P01116-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3845

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3845

UCSC genome browser

More...
UCSCi
uc001rgp.3 human [P01116-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00049
, L00045, L00046, L00047 Genomic DNA Translation: AAB59444.1
L00048
, L00045, L00046, L00047 Genomic DNA Translation: AAB59445.1
M54968 mRNA Translation: AAB41942.1
AF493917 mRNA Translation: AAM12631.1
BT007153 mRNA Translation: AAP35817.1
AK292510 mRNA Translation: BAF85199.1
CH471094 Genomic DNA Translation: EAW96511.1
CH471094 Genomic DNA Translation: EAW96512.1
EU332849 Genomic DNA Translation: ABY87538.1
BC013572 mRNA Translation: AAH13572.1
K01519 Genomic DNA No translation available.
K01520 Genomic DNA No translation available.
M25876 Genomic DNA Translation: AAA35683.1
M34904 Genomic DNA Translation: AAA36149.1
M30539 Genomic DNA Translation: AAA36557.1
X01669 Genomic DNA Translation: CAA25828.1
X02825 Genomic DNA Translation: CAA26593.1
K03210, K03209 Genomic DNA Translation: AAA36554.1
CCDSiCCDS8702.1 [P01116-2]
CCDS8703.1 [P01116-1]
PIRiA93311 TVHUK
B93311 TVHU2K
RefSeqiNP_004976.2, NM_004985.4 [P01116-2]
NP_203524.1, NM_033360.3 [P01116-1]
XP_006719132.1, XM_006719069.3
XP_011518955.1, XM_011520653.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D8DX-ray2.00P178-188[»]
1D8EX-ray3.00P178-188[»]
1KZOX-ray2.20C169-173[»]
1KZPX-ray2.10C169-173[»]
1N4PX-ray2.65M/N185-189[»]
1N4QX-ray2.40M/N/O/P/Q/R185-189[»]
1N4RX-ray2.80M/N/O/P/Q/R185-189[»]
1N4SX-ray2.60M/N/O/P/Q/R185-189[»]
3GFTX-ray2.27A/B/C/D/E/F1-164[»]
4DSNX-ray2.03A2-164[»]
4DSOX-ray1.85A2-164[»]
4EPRX-ray2.00A1-164[»]
4EPTX-ray2.00A1-164[»]
4EPVX-ray1.35A1-164[»]
4EPWX-ray1.70A1-164[»]
4EPXX-ray1.76A1-164[»]
4EPYX-ray1.80A1-164[»]
4L8GX-ray1.52A1-169[»]
4LDJX-ray1.15A1-164[»]
4LPKX-ray1.50A/B1-169[»]
4LRWX-ray2.15A/B1-169[»]
4LUCX-ray1.29A/B1-169[»]
4LV6X-ray1.50A/B1-169[»]
4LYFX-ray1.57A/B/C1-169[»]
4LYHX-ray1.37A/B/C1-169[»]
4LYJX-ray1.93A1-169[»]
4M1OX-ray1.57A/B/C1-169[»]
4M1SX-ray1.55A/B/C1-169[»]
4M1TX-ray1.70A/B/C1-169[»]
4M1WX-ray1.58A/B/C1-169[»]
4M1YX-ray1.49A/B/C1-169[»]
4M21X-ray1.94A/B/C1-169[»]
4M22X-ray2.09A/B/C1-169[»]
4NMMX-ray1.89A1-164[»]
4OBEX-ray1.24A/B1-164[»]
4PZYX-ray1.88A/B1-164[»]
4PZZX-ray1.40A1-164[»]
4Q01X-ray1.29A/B1-164[»]
4Q02X-ray1.70A1-164[»]
4Q03X-ray1.20A1-164[»]
4QL3X-ray1.04A1-11[»]
A13-164[»]
4TQ9X-ray1.49A/B1-164[»]
4TQAX-ray1.13A/B1-164[»]
4WA7X-ray1.99A1-164[»]
5F2EX-ray1.40A1-169[»]
5KYKX-ray2.70A/B/C1-167[»]
5MLAX-ray2.19A1-166[»]
5MLBX-ray3.22A/C/E/G1-166[»]
5O2SX-ray3.22A/C/E/G1-166[»]
5O2TX-ray2.19A1-166[»]
5OCGX-ray1.48A2-189[»]
5OCOX-ray1.66A/B/C/D/E/F1-169[»]
5OCTX-ray2.07A/B/C/D/E/F1-169[»]
5TARX-ray1.90A2-164[»]
5TB5X-ray2.00A/C2-164[»]
5UFEX-ray2.30A1-166[»]
5UFQX-ray2.20A/B1-166[»]
5UK9X-ray1.89A/B1-166[»]
5UQWX-ray1.50A/B1-164[»]
5US4X-ray1.83A/B1-164[»]
5USJX-ray1.94A/B/C/D/E/F1-164[»]
5V6SX-ray1.70A1-169[»]
5V6VX-ray1.72A/B1-169[»]
5V71X-ray2.23A/B/C/D/E/F1-167[»]
5V9LX-ray1.98A/B/C1-167[»]
5V9OX-ray1.56A1-167[»]
5V9UX-ray1.38A/B1-169[»]
5VBMX-ray1.49A1-169[»]
5VP7X-ray1.70A/F1-169[»]
5VPIX-ray1.62A/B1-169[»]
5VPYX-ray2.00A/B1-169[»]
5VPZX-ray1.85A/B1-169[»]
5VQ0X-ray2.30A/B1-169[»]
5VQ1X-ray1.78A/B1-169[»]
5VQ2X-ray1.96A/B1-169[»]
5VQ6X-ray1.99A/B1-169[»]
5VQ8X-ray2.30A/B1-169[»]
5W22X-ray1.76A/B1-169[»]
5WHAX-ray2.04A/D/G/J1-166[»]
5WHBX-ray2.18A/D/G/J1-166[»]
5WHDX-ray1.64A/B/C/D1-166[»]
5WHEX-ray1.91A/D/G/J1-166[»]
5WLBX-ray1.72A/D1-166[»]
5WPMX-ray1.72A1-166[»]
5XCOX-ray1.25A1-169[»]
5YXZX-ray1.70A1-169[»]
5YY1X-ray1.69A1-169[»]
6ARKX-ray1.75A1-169[»]
6ASAX-ray2.54A1-167[»]
6ASEX-ray1.55A1-169[»]
6B0VX-ray1.29A/B1-169[»]
6B0YX-ray1.43A/B1-169[»]
6BOFX-ray1.40A/B2-169[»]
6BP1X-ray2.00A1-169[»]
6CC9NMR-B1-186[»]
6CCHNMR-B1-186[»]
6CCXNMR-B1-186[»]
6E6FX-ray3.40A/B1-166[»]
6E6GX-ray1.93A1-166[»]
6EPLX-ray2.55R1-169[»]
6EPMX-ray2.50R1-169[»]
6EPNX-ray2.50R1-169[»]
6EPOX-ray2.40R1-169[»]
6EPPX-ray2.40R1-169[»]
6F76X-ray2.20A/B/C/D/E/F1-169[»]
6FA1X-ray1.97A/C/D/F1-167[»]
B/E1-169[»]
6FA2X-ray2.60A/B/C/D/E/F1-167[»]
6FA3X-ray1.82A/B/C/D/E/F1-167[»]
6FA4X-ray2.02A/B/C/D/E/F1-169[»]
6GJ5X-ray1.50A/B1-169[»]
6GJ6X-ray1.76A1-169[»]
6GJ7X-ray1.67A1-169[»]
6GJ8X-ray1.65A1-167[»]
6GODX-ray1.71A2-173[»]
6GOEX-ray1.60A2-169[»]
6GOFX-ray1.98A2-173[»]
6GOGX-ray2.05A/B/C/D/E/F1-169[»]
6GOMX-ray1.63A/B/C/D/E/F1-167[»]
6GQTX-ray1.69A/B/C/D/E/F1-167[»]
6GQWX-ray2.80A/B/C/D/E/F1-167[»]
6GQXX-ray2.20A/B/C/D/E/F1-167[»]
6GQYX-ray2.75A/B/C/D/E/F1-167[»]
6H46X-ray2.22A1-166[»]
6H47X-ray1.70A1-166[»]
6M9WX-ray1.50A2-169[»]
6MBQX-ray1.35A2-166[»]
6MBTX-ray1.45A/B1-169[»]
6MBUX-ray1.45A/B1-169[»]
6MQGX-ray1.50A3-169[»]
6MQNX-ray1.60A/B/C1-169[»]
6N2JX-ray1.80A1-169[»]
6N2KX-ray1.72A1-169[»]
6P0ZX-ray1.01A/B2-169[»]
6P8WX-ray2.10A/B1-169[»]
6P8XX-ray2.11A/B/C/D1-169[»]
6P8YX-ray2.31A/B1-169[»]
6P8ZX-ray1.65A/B1-169[»]
6QUUX-ray1.48A/B1-169[»]
6QUVX-ray1.48A/B1-169[»]
6QUWX-ray1.24A/B1-169[»]
6QUXX-ray1.62A/B1-169[»]
SMRiP01116
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110043, 968 interactors
CORUMiP01116
DIPiDIP-33951N
IntActiP01116, 72 interactors
MINTiP01116
STRINGi9606.ENSP00000256078

Chemistry databases

BindingDBiP01116
ChEMBLiCHEMBL2189121
DrugBankiDB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
DB07780 Farnesyl diphosphate
GuidetoPHARMACOLOGYi2824

PTM databases

iPTMnetiP01116
PhosphoSitePlusiP01116
SwissPalmiP01116

Polymorphism and mutation databases

BioMutaiKRAS
DMDMi131875

Proteomic databases

EPDiP01116
jPOSTiP01116
MassIVEiP01116
MaxQBiP01116
PaxDbiP01116
PeptideAtlasiP01116
PRIDEiP01116
ProteomicsDBi51323 [P01116-1]
51324 [P01116-2]
TopDownProteomicsiP01116-2 [P01116-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3845

Genome annotation databases

EnsembliENST00000256078; ENSP00000256078; ENSG00000133703 [P01116-1]
ENST00000311936; ENSP00000308495; ENSG00000133703 [P01116-2]
GeneIDi3845
KEGGihsa:3845
UCSCiuc001rgp.3 human [P01116-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3845
DisGeNETi3845

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRAS
GeneReviewsiKRAS
HGNCiHGNC:6407 KRAS
HPAiHPA049830
MalaCardsiKRAS
MIMi190070 gene
601626 phenotype
607785 phenotype
609942 phenotype
613659 phenotype
615278 phenotype
neXtProtiNX_P01116
OpenTargetsiENSG00000133703
Orphaneti1340 Cardiofaciocutaneous syndrome
146 Differentiated thyroid carcinoma
2396 Encephalocraniocutaneous lipomatosis
1333 Familial pancreatic carcinoma
86834 Juvenile myelomonocytic leukemia
2612 Linear nevus sebaceus syndrome
144 Lynch syndrome
648 Noonan syndrome
251615 Pilomyxoid astrocytoma
268114 RAS-associated autoimmune leukoproliferative disease
357194 Selection of therapeutic option in colorectal cancer
357191 Selection of therapeutic option in non-small cell lung carcinoma
3339 Toriello-Lacassie-Droste syndrome
PharmGKBiPA30196

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00940000155871
HOGENOMiHOG000233973
InParanoidiP01116
KOiK07827
OMAiPTVENCY
OrthoDBi1586678at2759
PhylomeDBiP01116
TreeFamiTF312796

Enzyme and pathway databases

ReactomeiR-HSA-112412 SOS-mediated signalling
R-HSA-1169092 Activation of RAS in B cells
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-167044 Signalling to RAS
R-HSA-171007 p38MAPK events
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-186763 Downstream signal transduction
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-210993 Tie2 Signaling
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2424491 DAP12 signaling
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-8951936 RUNX3 regulates p14-ARF
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9607240 FLT3 Signaling
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ
SignaLinkiP01116
SIGNORiP01116

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRAS human
EvolutionaryTraceiP01116

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KRAS

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3845
PharosiP01116

Protein Ontology

More...
PROi
PR:P01116

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133703 Expressed in 243 organ(s), highest expression level in colon
ExpressionAtlasiP01116 baseline and differential
GenevisibleiP01116 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01116
Secondary accession number(s): A8K8Z5
, B0LPF9, P01118, Q96D10
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2019
This is version 236 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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