UniProtKB - P01112 (RASH_HUMAN)
GTPase HRas
HRAS
Functioni
Catalytic activityi
- EC:3.6.5.21 Publication
Activity regulationi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 13 – 18 | GTP1 Publication | 6 | |
Nucleotide bindingi | 29 – 35 | GTP1 Publication | 7 | |
Nucleotide bindingi | 59 – 60 | GTP1 Publication | 2 | |
Nucleotide bindingi | 116 – 119 | GTP1 Publication | 4 | |
Nucleotide bindingi | 145 – 147 | GTP1 Publication | 3 |
GO - Molecular functioni
- GDP binding Source: CAFA
- GTPase activity Source: WormBase
- GTP binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein C-terminus binding Source: UniProtKB
GO - Biological processi
- animal organ morphogenesis Source: ProtInc
- cell cycle arrest Source: BHF-UCL
- cell surface receptor signaling pathway Source: ProtInc
- cellular response to gamma radiation Source: CAFA
- cellular senescence Source: BHF-UCL
- chemotaxis Source: ProtInc
- defense response to protozoan Source: Ensembl
- endocytosis Source: Ensembl
- ephrin receptor signaling pathway Source: Reactome
- intrinsic apoptotic signaling pathway Source: Ensembl
- liver development Source: Ensembl
- MAPK cascade Source: Reactome
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of GTPase activity Source: BHF-UCL
- negative regulation of neuron apoptotic process Source: Ensembl
- positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of DNA replication Source: Ensembl
- positive regulation of epithelial cell proliferation Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of GTPase activity Source: BHF-UCL
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of JNK cascade Source: BHF-UCL
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of MAP kinase activity Source: BHF-UCL
- positive regulation of miRNA metabolic process Source: BHF-UCL
- positive regulation of phospholipase C activity Source: UniProtKB
- positive regulation of protein phosphorylation Source: BHF-UCL
- positive regulation of protein targeting to membrane Source: UniProtKB
- positive regulation of Ras protein signal transduction Source: Ensembl
- positive regulation of ruffle assembly Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of wound healing Source: BHF-UCL
- Ras protein signal transduction Source: BHF-UCL
- regulation of long-term neuronal synaptic plasticity Source: Ensembl
- regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Source: SynGO
- response to isolation stress Source: Ensembl
- signal transduction Source: ProtInc
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Ensembl
- T-helper 1 type immune response Source: Ensembl
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P01112 |
Reactomei | R-HSA-112412, SOS-mediated signalling R-HSA-1169092, Activation of RAS in B cells R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1250196, SHC1 events in ERBB2 signaling R-HSA-1250347, SHC1 events in ERBB4 signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-167044, Signalling to RAS R-HSA-171007, p38MAPK events R-HSA-179812, GRB2 events in EGFR signaling R-HSA-180336, SHC1 events in EGFR signaling R-HSA-186763, Downstream signal transduction R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-210993, Tie2 Signaling R-HSA-2179392, EGFR Transactivation by Gastrin R-HSA-2424491, DAP12 signaling R-HSA-2428933, SHC-related events triggered by IGF1R R-HSA-2871796, FCERI mediated MAPK activation R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-3928662, EPHB-mediated forward signaling R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5637810, Constitutive Signaling by EGFRvIII R-HSA-5654688, SHC-mediated cascade:FGFR1 R-HSA-5654693, FRS-mediated FGFR1 signaling R-HSA-5654699, SHC-mediated cascade:FGFR2 R-HSA-5654700, FRS-mediated FGFR2 signaling R-HSA-5654704, SHC-mediated cascade:FGFR3 R-HSA-5654706, FRS-mediated FGFR3 signaling R-HSA-5654712, FRS-mediated FGFR4 signaling R-HSA-5654719, SHC-mediated cascade:FGFR4 R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655291, Signaling by FGFR4 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5673000, RAF activation R-HSA-5673001, RAF/MAP kinase cascade R-HSA-5674135, MAP2K and MAPK activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802953, RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-74751, Insulin receptor signalling cascade R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8851805, MET activates RAS signaling R-HSA-8853334, Signaling by FGFR3 fusions in cancer R-HSA-8853338, Signaling by FGFR3 point mutants in cancer R-HSA-9026519, Activated NTRK2 signals through RAS R-HSA-9027284, Erythropoietin activates RAS R-HSA-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9034864, Activated NTRK3 signals through RAS R-HSA-9607240, FLT3 Signaling R-HSA-9634285, Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ R-HSA-9648002, RAS processing R-HSA-9649913, RAS GTPase cycle mutants R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9664565, Signaling by ERBB2 KD Mutants R-HSA-9665348, Signaling by ERBB2 ECD mutants R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants R-HSA-9703465, Signaling by FLT3 fusion proteins R-HSA-9703648, Signaling by FLT3 ITD and TKD mutants |
SABIO-RKi | P01112 |
SignaLinki | P01112 |
SIGNORi | P01112 |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase HRas (EC:3.6.5.21 Publication)Alternative name(s): H-Ras-1 Ha-Ras Transforming protein p21 c-H-ras p21ras Cleaved into the following chain: |
Gene namesi | Name:HRAS Synonyms:HRAS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5173, HRAS |
MIMi | 190020, gene |
neXtProti | NX_P01112 |
VEuPathDBi | HostDB:ENSG00000174775.16 |
Subcellular locationi
Plasma membrane
Golgi apparatus
Note: The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus.By similarity
Cytoplasm and Cytosol
Nucleus
Other locations
Note: Colocalizes with RACK1 to the perinuclear region.
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: Reactome
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: ProtInc
- glutamatergic synapse Source: SynGO
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Costello syndrome (CSTLO)7 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026106 | 12 | G → A in CSTLO. 3 PublicationsCorresponds to variant dbSNP:rs104894230EnsemblClinVar. | 1 | |
Natural variantiVAR_045975 | 12 | G → C in CSTLO. 2 PublicationsCorresponds to variant dbSNP:rs104894229EnsemblClinVar. | 1 | |
Natural variantiVAR_068816 | 12 | G → D in CSTLO; severe mutation. 1 PublicationCorresponds to variant dbSNP:rs104894230EnsemblClinVar. | 1 | |
Natural variantiVAR_045976 | 12 | G → E in CSTLO. 1 Publication | 1 | |
Natural variantiVAR_006837 | 12 | G → S in CSTLO and CMEMS; also found in patients with oral squamous cell carcinoma. 6 PublicationsCorresponds to variant dbSNP:rs104894229EnsemblClinVar. | 1 | |
Natural variantiVAR_006836 | 12 | G → V in CSTLO, bladder carcinoma and CMEMS; constitutively activated; interacts and recruits PLCE1 to plasma membrane. 4 PublicationsCorresponds to variant dbSNP:rs104894230EnsemblClinVar. | 1 | |
Natural variantiVAR_026107 | 13 | G → C in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs104894228EnsemblClinVar. | 1 | |
Natural variantiVAR_026108 | 13 | G → D in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs104894226EnsemblClinVar. | 1 | |
Natural variantiVAR_068818 | 37 | E → EE in CSTLO. 1 Publication | 1 | |
Natural variantiVAR_045978 | 58 | T → I in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs121917758EnsemblClinVar. | 1 | |
Natural variantiVAR_045981 | 117 | K → R in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs104894227EnsemblClinVar. | 1 | |
Natural variantiVAR_045982 | 146 | A → T in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs104894231EnsemblClinVar. | 1 | |
Natural variantiVAR_045983 | 146 | A → V in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs121917759EnsemblClinVar. | 1 |
Congenital myopathy with excess of muscle spindles (CMEMS)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006837 | 12 | G → S in CSTLO and CMEMS; also found in patients with oral squamous cell carcinoma. 6 PublicationsCorresponds to variant dbSNP:rs104894229EnsemblClinVar. | 1 | |
Natural variantiVAR_006836 | 12 | G → V in CSTLO, bladder carcinoma and CMEMS; constitutively activated; interacts and recruits PLCE1 to plasma membrane. 4 PublicationsCorresponds to variant dbSNP:rs104894230EnsemblClinVar. | 1 | |
Natural variantiVAR_045977 | 22 | Q → K in CMEMS. 1 PublicationCorresponds to variant dbSNP:rs121917757EnsemblClinVar. | 1 | |
Natural variantiVAR_045980 | 63 | E → K in CMEMS. 1 PublicationCorresponds to variant dbSNP:rs121917756EnsemblClinVar. | 1 |
Thyroid cancer, non-medullary, 2 (NMTC2)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045979 | 61 | Q → K in NMTC2; somatic mutation; increases transformation of cultured cell lines. 2 PublicationsCorresponds to variant dbSNP:rs28933406EnsemblClinVar. | 1 |
Bladder cancer (BLC)2 Publications
Schimmelpenning-Feuerstein-Mims syndrome (SFM)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068817 | 13 | G → R in SFM; somatic mutation; shows constitutive activation of the MAPK and PI3K-AKT signaling pathways. 1 PublicationCorresponds to variant dbSNP:rs104894228EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 17 | S → N: Dominant negative. Prevents PLCE1 EGF-induced recruitment to plasma membrane. No effect on subcellular location of isoform 2. 2 Publications | 1 | |
Mutagenesisi | 26 | N → G: Loss of interaction with PLCE1; when associated with V-12. 1 Publication | 1 | |
Mutagenesisi | 29 | V → A: No effect on interaction with PLCE1; when associated with V-12. 1 Publication | 1 | |
Mutagenesisi | 32 | Y → F: Loss of interaction and recruitment to plasma membrane of PLCE1; when associated with V-12. 1 Publication | 1 | |
Mutagenesisi | 34 | P → G: No effect on interaction with PLCE1; when associated with V-12. 1 Publication | 1 | |
Mutagenesisi | 35 | T → S: Loss of interaction with PLCE1; when associated with V-12. 1 Publication | 1 | |
Mutagenesisi | 37 | E → G: No effect on interaction with PLCE1; when associated with V-12. 1 Publication | 1 | |
Mutagenesisi | 38 | D → N: No effect on interaction with PLCE1; when associated with V-12. 1 Publication | 1 | |
Mutagenesisi | 39 | S → C: No effect on interaction with PLCE1; when associated with V-12. 1 Publication | 1 | |
Mutagenesisi | 59 | A → T: Loss of GTPase activity and creation of an autophosphorylation site. | 1 | |
Mutagenesisi | 61 | Q → I: Moderately increased transformation of cultured cell lines. 1 Publication | 1 | |
Mutagenesisi | 61 | Q → V: Strongly increased transformation of cultured cell lines. 1 Publication | 1 | |
Mutagenesisi | 83 | A → T: GTP-binding activity reduced by factor of 30. 1 Publication | 1 | |
Mutagenesisi | 118 | C → S: Abolishes S-nitrosylation. No stimulation of guanine nucleotide exchange. 2 Publications | 1 | |
Mutagenesisi | 119 | D → N: Loss of GTP-binding activity. 1 Publication | 1 | |
Mutagenesisi | 144 | T → I: GTP-binding activity reduced by factor of 25. 1 Publication | 1 | |
Mutagenesisi | 164 – 165 | RQ → AV: Loss of GTP-binding activity. 1 Publication | 2 | |
Mutagenesisi | 170 | K → R: Increased Ras signaling due to impaired ubiquitination. 1 Publication | 1 | |
Mutagenesisi | 181 | C → S: Exclusively localized in Golgi. Non-specifically localized on all endomembranes; when associated with S-184. 2 Publications | 1 | |
Mutagenesisi | 184 | C → S: Loss of S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine stimulation of Ras-GTPase activity. Mainly localized in Golgi. Non-specifically localized on all endomembranes; when associated with S-181. 3 Publications | 1 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 3265 |
GeneReviewsi | HRAS |
MalaCardsi | HRAS |
MIMi | 109800, phenotype 163200, phenotype 188470, phenotype 218040, phenotype |
OpenTargetsi | ENSG00000174775 |
Orphaneti | 3071, Costello syndrome 146, Differentiated thyroid carcinoma 2612, Linear nevus sebaceus syndrome 2874, Phakomatosis pigmentokeratotica 79414, Woolly hair nevus |
PharmGKBi | PA29444 |
Miscellaneous databases
Pharosi | P01112, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2167 |
DrugBanki | DB04315, Guanosine-5'-Diphosphate DB04137, Guanosine-5'-Triphosphate DB02210, Hexane-1,6-Diol DB08751, N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE DB03226, Trifluoroethanol |
DrugCentrali | P01112 |
GuidetoPHARMACOLOGYi | 2822 |
Genetic variation databases
BioMutai | HRAS |
DMDMi | 131869 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000042996 | 1 – 186 | GTPase HRasAdd BLAST | 186 | |
Initiator methioninei | Removed; alternate1 Publication | |||
ChainiPRO_0000326476 | 2 – 186 | GTPase HRas, N-terminally processedAdd BLAST | 185 | |
PropeptideiPRO_0000042997 | 187 – 189 | Removed in mature form | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine; in GTPase HRas; alternate1 Publication | 1 | |
Modified residuei | 2 | N-acetylthreonine; in GTPase HRas, N-terminally processed1 Publication | 1 | |
Glycosylationi | 35 | (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL4 Publications | 1 | |
Modified residuei | 118 | S-nitrosocysteine1 Publication | 1 | |
Cross-linki | 170 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Lipidationi | 181 | S-palmitoyl cysteine4 Publications | 1 | |
Lipidationi | 184 | S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine; alternate1 Publication | 1 | |
Lipidationi | 184 | S-palmitoyl cysteine; alternate4 Publications | 1 | |
Modified residuei | 186 | Cysteine methyl ester1 Publication | 1 | |
Lipidationi | 186 | S-farnesyl cysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Lipoprotein, Methylation, Palmitate, Prenylation, S-nitrosylation, Ubl conjugationProteomic databases
CPTACi | CPTAC-1551 CPTAC-1552 |
EPDi | P01112 |
jPOSTi | P01112 |
MassIVEi | P01112 |
PaxDbi | P01112 |
PeptideAtlasi | P01112 |
PRIDEi | P01112 |
ProteomicsDBi | 12698 [P01112-2] 51321 [P01112-1] 51322 [P01112-2] |
PTM databases
iPTMneti | P01112 |
PhosphoSitePlusi | P01112 |
SwissPalmi | P01112 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000174775, Expressed in skin of abdomen and 239 other tissues |
ExpressionAtlasi | P01112, baseline and differential |
Genevisiblei | P01112, HS |
Organism-specific databases
HPAi | ENSG00000174775, Low tissue specificity |
Interactioni
Subunit structurei
In its GTP-bound form interacts with PLCE1 (PubMed:11022048).
Interacts with TBC1D10C (PubMed:17230191).
Interacts with RGL3 (By similarity).
Interacts with HSPD1 (By similarity).
Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (By similarity).
Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity).
Forms a signaling complex with RASGRP1 and DGKZ (PubMed:11257115).
Interacts with RASSF5 (PubMed:18596699).
Interacts with PDE6D (PubMed:11980706).
Interacts with IKZF3 (PubMed:10369681).
Interacts with RACK1 (PubMed:14500341).
Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity).
Interacts with RAPGEF2 (PubMed:10608844, PubMed:11598133).
By similarity10 PublicationsBinary interactionsi
P01112
Isoform 2 [P01112-2]
With | #Exp. | IntAct |
---|---|---|
RAP1GDS1 - isoform 5 [P52306-5] | 5 | EBI-13290525,EBI-12832744 |
GO - Molecular functioni
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109501, 644 interactors |
ComplexPortali | CPX-395, GTPase HRAS - Son of sevenless homolog 1 complex |
CORUMi | P01112 |
DIPi | DIP-1050N |
ELMi | P01112 |
IntActi | P01112, 197 interactors |
MINTi | P01112 |
STRINGi | 9606.ENSP00000407586 |
Chemistry databases
BindingDBi | P01112 |
Miscellaneous databases
RNActi | P01112, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P01112 |
SMRi | P01112 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01112 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 185 | Hypervariable regionAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 32 – 40 | Effector region | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000155653 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | P01112 |
OMAi | EPDEHIC |
OrthoDBi | 743479at2759 |
PhylomeDBi | P01112 |
TreeFami | TF312796 |
Family and domain databases
DisProti | DP00153 |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL AARTVESRQA QDLARSYGIP YIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQHKLRK LNPPDESGPG CMSCKCVLS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YXG8 | A0A0J9YXG8_HUMAN | GTPase HRas | HRAS | 14 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026106 | 12 | G → A in CSTLO. 3 PublicationsCorresponds to variant dbSNP:rs104894230EnsemblClinVar. | 1 | |
Natural variantiVAR_045975 | 12 | G → C in CSTLO. 2 PublicationsCorresponds to variant dbSNP:rs104894229EnsemblClinVar. | 1 | |
Natural variantiVAR_068816 | 12 | G → D in CSTLO; severe mutation. 1 PublicationCorresponds to variant dbSNP:rs104894230EnsemblClinVar. | 1 | |
Natural variantiVAR_045976 | 12 | G → E in CSTLO. 1 Publication | 1 | |
Natural variantiVAR_006837 | 12 | G → S in CSTLO and CMEMS; also found in patients with oral squamous cell carcinoma. 6 PublicationsCorresponds to variant dbSNP:rs104894229EnsemblClinVar. | 1 | |
Natural variantiVAR_006836 | 12 | G → V in CSTLO, bladder carcinoma and CMEMS; constitutively activated; interacts and recruits PLCE1 to plasma membrane. 4 PublicationsCorresponds to variant dbSNP:rs104894230EnsemblClinVar. | 1 | |
Natural variantiVAR_026107 | 13 | G → C in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs104894228EnsemblClinVar. | 1 | |
Natural variantiVAR_026108 | 13 | G → D in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs104894226EnsemblClinVar. | 1 | |
Natural variantiVAR_068817 | 13 | G → R in SFM; somatic mutation; shows constitutive activation of the MAPK and PI3K-AKT signaling pathways. 1 PublicationCorresponds to variant dbSNP:rs104894228EnsemblClinVar. | 1 | |
Natural variantiVAR_045977 | 22 | Q → K in CMEMS. 1 PublicationCorresponds to variant dbSNP:rs121917757EnsemblClinVar. | 1 | |
Natural variantiVAR_068818 | 37 | E → EE in CSTLO. 1 Publication | 1 | |
Natural variantiVAR_045978 | 58 | T → I in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs121917758EnsemblClinVar. | 1 | |
Natural variantiVAR_045979 | 61 | Q → K in NMTC2; somatic mutation; increases transformation of cultured cell lines. 2 PublicationsCorresponds to variant dbSNP:rs28933406EnsemblClinVar. | 1 | |
Natural variantiVAR_006838 | 61 | Q → L in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines. 1 PublicationCorresponds to variant dbSNP:rs121913233EnsemblClinVar. | 1 | |
Natural variantiVAR_045980 | 63 | E → K in CMEMS. 1 PublicationCorresponds to variant dbSNP:rs121917756EnsemblClinVar. | 1 | |
Natural variantiVAR_078259 | 89 | S → C Found in a patient with severe fetal hydrops and pleural effusion; unknown pathological significance; decreased activation of Ras protein signal transduction. 1 PublicationCorresponds to variant dbSNP:rs755322824EnsemblClinVar. | 1 | |
Natural variantiVAR_045981 | 117 | K → R in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs104894227EnsemblClinVar. | 1 | |
Natural variantiVAR_045982 | 146 | A → T in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs104894231EnsemblClinVar. | 1 | |
Natural variantiVAR_045983 | 146 | A → V in CSTLO. 1 PublicationCorresponds to variant dbSNP:rs121917759EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041597 | 152 – 189 | VEDAF…KCVLS → SRSGSSSSSGTLWDPPGPM in isoform 2. 2 PublicationsAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00277 Genomic DNA Translation: AAB02605.1 AJ437024 mRNA Translation: CAD24594.1 AF493916 mRNA Translation: AAM12630.1 CR536579 mRNA Translation: CAG38816.1 CR542271 mRNA Translation: CAG47067.1 BT019421 mRNA Translation: AAV38228.1 EF015887 Genomic DNA Translation: ABI97389.1 AB451336 mRNA Translation: BAG70150.1 AB451485 mRNA Translation: BAG70299.1 CH471158 Genomic DNA Translation: EAX02337.1 CH471158 Genomic DNA Translation: EAX02338.1 BC006499 mRNA Translation: AAH06499.1 BC095471 mRNA Translation: AAH95471.1 M17232 Genomic DNA Translation: AAA35685.1 |
CCDSi | CCDS7698.1 [P01112-1] CCDS7699.1 [P01112-2] |
PIRi | A93299, TVHUH |
RefSeqi | NP_001123914.1, NM_001130442.2 [P01112-1] NP_001304983.1, NM_001318054.1 NP_005334.1, NM_005343.3 [P01112-1] NP_789765.1, NM_176795.4 [P01112-2] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00277 Genomic DNA Translation: AAB02605.1 AJ437024 mRNA Translation: CAD24594.1 AF493916 mRNA Translation: AAM12630.1 CR536579 mRNA Translation: CAG38816.1 CR542271 mRNA Translation: CAG47067.1 BT019421 mRNA Translation: AAV38228.1 EF015887 Genomic DNA Translation: ABI97389.1 AB451336 mRNA Translation: BAG70150.1 AB451485 mRNA Translation: BAG70299.1 CH471158 Genomic DNA Translation: EAX02337.1 CH471158 Genomic DNA Translation: EAX02338.1 BC006499 mRNA Translation: AAH06499.1 BC095471 mRNA Translation: AAH95471.1 M17232 Genomic DNA Translation: AAA35685.1 |
CCDSi | CCDS7698.1 [P01112-1] CCDS7699.1 [P01112-2] |
PIRi | A93299, TVHUH |
RefSeqi | NP_001123914.1, NM_001130442.2 [P01112-1] NP_001304983.1, NM_001318054.1 NP_005334.1, NM_005343.3 [P01112-1] NP_789765.1, NM_176795.4 [P01112-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
121P | X-ray | 1.54 | A | 1-166 | [»] | |
1AA9 | NMR | - | A | 1-171 | [»] | |
1AGP | X-ray | 2.30 | A | 1-166 | [»] | |
1BKD | X-ray | 2.80 | R | 1-166 | [»] | |
1CLU | X-ray | 1.70 | A | 1-166 | [»] | |
1CRP | NMR | - | A | 1-166 | [»] | |
1CRQ | NMR | - | A | 1-166 | [»] | |
1CRR | NMR | - | A | 1-166 | [»] | |
1CTQ | X-ray | 1.26 | A | 1-166 | [»] | |
1GNP | X-ray | 2.70 | A | 1-166 | [»] | |
1GNQ | X-ray | 2.50 | A | 1-166 | [»] | |
1GNR | X-ray | 1.85 | A | 1-166 | [»] | |
1HE8 | X-ray | 3.00 | B | 1-166 | [»] | |
1IAQ | X-ray | 2.90 | A/B/C | 1-166 | [»] | |
1IOZ | X-ray | 2.00 | A | 1-171 | [»] | |
1JAH | X-ray | 1.80 | A | 1-166 | [»] | |
1JAI | X-ray | 1.80 | A | 1-166 | [»] | |
1K8R | X-ray | 3.00 | A | 1-166 | [»] | |
1LF0 | X-ray | 1.70 | A | 1-166 | [»] | |
1LF5 | X-ray | 1.70 | A | 1-166 | [»] | |
1LFD | X-ray | 2.10 | B/D | 1-167 | [»] | |
1NVU | X-ray | 2.20 | Q/R | 1-166 | [»] | |
1NVV | X-ray | 2.18 | Q/R | 1-166 | [»] | |
1NVW | X-ray | 2.70 | Q/R | 1-166 | [»] | |
1NVX | X-ray | 3.20 | Q/R | 1-166 | [»] | |
1P2S | X-ray | 2.45 | A | 1-166 | [»] | |
1P2T | X-ray | 2.00 | A | 1-166 | [»] | |
1P2U | X-ray | 2.00 | A | 1-166 | [»] | |
1P2V | X-ray | 2.30 | A | 1-166 | [»] | |
1PLJ | X-ray | 2.80 | A | 1-166 | [»] | |
1PLK | X-ray | 2.80 | A | 1-166 | [»] | |
1PLL | X-ray | 2.80 | A | 1-166 | [»] | |
1Q21 | X-ray | 2.20 | A | 1-171 | [»] | |
1QRA | X-ray | 1.60 | A | 1-166 | [»] | |
1RVD | X-ray | 1.90 | A | 1-166 | [»] | |
1WQ1 | X-ray | 2.50 | R | 1-166 | [»] | |
1XCM | X-ray | 1.84 | A | 1-167 | [»] | |
1XD2 | X-ray | 2.70 | A/B | 1-166 | [»] | |
1XJ0 | X-ray | 1.70 | A | 1-166 | [»] | |
1ZVQ | X-ray | 2.00 | A | 1-166 | [»] | |
1ZW6 | X-ray | 1.50 | A | 1-166 | [»] | |
221P | X-ray | 2.30 | A | 1-166 | [»] | |
2C5L | X-ray | 1.90 | A/B | 1-166 | [»] | |
2CE2 | X-ray | 1.00 | X | 1-166 | [»] | |
2CL0 | X-ray | 1.80 | X | 1-166 | [»] | |
2CL6 | X-ray | 1.24 | X | 1-166 | [»] | |
2CL7 | X-ray | 1.25 | X | 1-166 | [»] | |
2CLC | X-ray | 1.30 | X | 1-166 | [»] | |
2CLD | X-ray | 1.22 | X | 1-166 | [»] | |
2EVW | X-ray | 1.05 | X | 1-166 | [»] | |
2GDP | model | - | A | 1-171 | [»] | |
2LCF | NMR | - | A | 1-166 | [»] | |
2LWI | NMR | - | A | 1-166 | [»] | |
2N42 | NMR | - | A | 1-166 | [»] | |
2N46 | NMR | - | A | 1-166 | [»] | |
2Q21 | X-ray | 2.20 | A | 1-171 | [»] | |
2QUZ | X-ray | 1.49 | A | 1-166 | [»] | |
2RGA | X-ray | 1.90 | A | 1-166 | [»] | |
2RGB | X-ray | 1.35 | A | 1-166 | [»] | |
2RGC | X-ray | 1.60 | A | 1-166 | [»] | |
2RGD | X-ray | 2.00 | A | 1-166 | [»] | |
2RGE | X-ray | 1.40 | A | 1-166 | [»] | |
2RGG | X-ray | 1.45 | A | 1-166 | [»] | |
2UZI | X-ray | 2.00 | R | 1-166 | [»] | |
2VH5 | X-ray | 2.70 | R | 1-166 | [»] | |
2X1V | X-ray | 1.70 | A | 1-166 | [»] | |
3DDC | X-ray | 1.80 | A | 1-166 | [»] | |
3I3S | X-ray | 1.36 | R | 1-166 | [»] | |
3K8Y | X-ray | 1.30 | A | 1-166 | [»] | |
3K9L | X-ray | 1.80 | A/B/C | 1-166 | [»] | |
3K9N | X-ray | 2.00 | A | 1-166 | [»] | |
3KKM | X-ray | 1.70 | A | 1-166 | [»] | |
3KKN | X-ray | 2.09 | A | 1-166 | [»] | |
3KUD | X-ray | 2.15 | A | 1-166 | [»] | |
3L8Y | X-ray | 2.02 | A | 1-166 | [»] | |
3L8Z | X-ray | 1.44 | A | 1-166 | [»] | |
3LBH | X-ray | 1.85 | A | 1-166 | [»] | |
3LBI | X-ray | 2.09 | A | 1-166 | [»] | |
3LBN | X-ray | 1.86 | A | 1-166 | [»] | |
3LO5 | X-ray | 2.57 | A/C/E | 1-166 | [»] | |
3OIU | X-ray | 1.32 | A | 1-166 | [»] | |
3OIV | X-ray | 1.84 | A | 1-166 | [»] | |
3OIW | X-ray | 1.30 | A | 1-166 | [»] | |
3RRY | X-ray | 1.60 | A | 1-166 | [»] | |
3RRZ | X-ray | 1.60 | A | 1-166 | [»] | |
3RS0 | X-ray | 1.40 | A | 1-166 | [»] | |
3RS2 | X-ray | 1.84 | A | 1-166 | [»] | |
3RS3 | X-ray | 1.52 | A | 1-166 | [»] | |
3RS4 | X-ray | 1.70 | A | 1-166 | [»] | |
3RS5 | X-ray | 1.68 | A | 1-166 | [»] | |
3RS7 | X-ray | 1.70 | A | 1-166 | [»] | |
3RSL | X-ray | 1.70 | A | 1-166 | [»] | |
3RSO | X-ray | 1.60 | A | 1-166 | [»] | |
3TGP | X-ray | 1.31 | A | 1-166 | [»] | |
421P | X-ray | 2.20 | A | 1-166 | [»] | |
4DLR | X-ray | 1.32 | A | 1-166 | [»] | |
4DLS | X-ray | 1.82 | A | 1-166 | [»] | |
4DLT | X-ray | 1.70 | A | 1-166 | [»] | |
4DLU | X-ray | 1.60 | A | 1-166 | [»] | |
4DLV | X-ray | 1.57 | A | 1-166 | [»] | |
4DLW | X-ray | 1.72 | A | 1-166 | [»] | |
4DLX | X-ray | 1.73 | A | 1-166 | [»] | |
4DLY | X-ray | 1.57 | A | 1-166 | [»] | |
4DLZ | X-ray | 1.66 | A | 1-166 | [»] | |
4DST | X-ray | 2.30 | A | 2-167 | [»] | |
4DSU | X-ray | 1.70 | A | 2-167 | [»] | |
4EFL | X-ray | 1.90 | A | 1-166 | [»] | |
4EFM | X-ray | 1.90 | A | 1-166 | [»] | |
4EFN | X-ray | 2.30 | A | 1-166 | [»] | |
4G0N | X-ray | 2.45 | A | 1-166 | [»] | |
4G3X | X-ray | 3.25 | A | 1-166 | [»] | |
4K81 | X-ray | 2.40 | B/D/F/H | 1-166 | [»] | |
4L9S | X-ray | 1.61 | A | 1-166 | [»] | |
4L9W | X-ray | 1.95 | A | 1-166 | [»] | |
4NYI | X-ray | 2.96 | Q/R | 1-166 | [»] | |
4NYJ | X-ray | 2.85 | Q/R | 1-166 | [»] | |
4NYM | X-ray | 3.55 | Q/R | 1-166 | [»] | |
4Q21 | X-ray | 2.00 | A | 1-189 | [»] | |
4RSG | neutron diffraction | 1.91 | A | 1-166 | [»] | |
4URU | X-ray | 2.83 | R | 1-166 | [»] | |
4URV | X-ray | 2.58 | R | 1-166 | [»] | |
4URW | X-ray | 2.76 | R | 1-166 | [»] | |
4URX | X-ray | 2.49 | R | 1-166 | [»] | |
4URY | X-ray | 2.47 | R | 1-166 | [»] | |
4URZ | X-ray | 2.24 | R | 1-166 | [»] | |
4US0 | X-ray | 2.17 | R | 1-166 | [»] | |
4US1 | X-ray | 2.65 | R | 1-166 | [»] | |
4US2 | X-ray | 2.48 | R | 1-166 | [»] | |
4XVQ | X-ray | 1.89 | A | 1-166 | [»] | |
4XVR | X-ray | 2.03 | A | 1-166 | [»] | |
521P | X-ray | 2.60 | A | 1-166 | [»] | |
5B2Z | X-ray | 1.56 | A | 1-166 | [»] | |
5B30 | X-ray | 1.60 | A | 1-166 | [»] | |
5E95 | X-ray | 1.40 | A | 1-166 | [»] | |
5P21 | X-ray | 1.35 | A | 1-166 | [»] | |
5VBE | X-ray | 1.57 | A | 1-166 | [»] | |
5VBZ | X-ray | 2.20 | A/B/C | 1-166 | [»] | |
5WDO | X-ray | 1.65 | A | 1-166 | [»] | |
5WDP | X-ray | 1.35 | A | 1-166 | [»] | |
5WDQ | X-ray | 1.25 | A | 1-166 | [»] | |
5WFO | X-ray | 1.99 | Q/R | 1-166 | [»] | |
5WFP | X-ray | 2.08 | Q/R | 1-166 | [»] | |
5WFQ | X-ray | 2.26 | Q/R | 1-166 | [»] | |
5WFR | X-ray | 2.46 | Q/R | 1-166 | [»] | |
5WPL | X-ray | 2.15 | A/D/G/J | 1-166 | [»] | |
5X9S | X-ray | 2.50 | A | 1-166 | [»] | |
5ZC6 | NMR | - | A | 1-166 | [»] | |
621P | X-ray | 2.40 | A | 1-166 | [»] | |
6AMB | X-ray | 2.50 | A | 1-168 | [»] | |
6AXG | X-ray | 3.30 | B/D/F/H/J/L | 1-166 | [»] | |
6BVI | X-ray | 1.75 | A/C | 1-166 | [»] | |
6BVJ | X-ray | 1.75 | A/C | 1-166 | [»] | |
6BVK | X-ray | 1.80 | A/C | 1-166 | [»] | |
6BVL | X-ray | 1.75 | A/C | 1-166 | [»] | |
6BVM | X-ray | 1.80 | A/C | 1-166 | [»] | |
6CUO | X-ray | 1.73 | A/C | 1-166 | [»] | |
6CUP | X-ray | 1.83 | A/C | 1-166 | [»] | |
6CUR | X-ray | 1.73 | A/C | 1-166 | [»] | |
6D55 | X-ray | 1.68 | A/C | 1-166 | [»] | |
6D56 | X-ray | 1.68 | A/C | 1-166 | [»] | |
6D59 | X-ray | 1.70 | A/C | 1-166 | [»] | |
6D5E | X-ray | 1.75 | A/C | 1-166 | [»] | |
6D5G | X-ray | 1.92 | A/C | 1-166 | [»] | |
6D5H | X-ray | 1.80 | A/C | 1-166 | [»] | |
6D5J | X-ray | 1.75 | A/C | 1-166 | [»] | |
6D5L | X-ray | 1.70 | A/C | 1-166 | [»] | |
6D5M | X-ray | 2.08 | Q/R | 1-166 | [»] | |
6D5V | X-ray | 2.04 | Q/R | 1-166 | [»] | |
6D5W | X-ray | 2.48 | Q/R | 1-166 | [»] | |
6DZH | X-ray | 1.95 | A/B/C | 1-166 | [»] | |
6E6C | X-ray | 1.90 | A | 1-166 | [»] | |
6E6P | X-ray | 1.93 | A/B/C | 1-166 | [»] | |
6MQT | X-ray | 1.50 | A/B/C/D/E/F/G/H | 1-166 | [»] | |
6NTC | X-ray | 2.90 | A | 1-166 | [»] | |
6NTD | X-ray | 3.15 | A | 1-166 | [»] | |
6Q21 | X-ray | 1.95 | A/B/C/D | 1-171 | [»] | |
6V94 | X-ray | 1.80 | A/C | 1-166 | [»] | |
6V9F | X-ray | 1.85 | A/C | 1-166 | [»] | |
6V9J | X-ray | 1.76 | A/C | 1-166 | [»] | |
6V9L | X-ray | 1.70 | A/C | 1-166 | [»] | |
6V9M | X-ray | 1.65 | A/C | 1-166 | [»] | |
6V9N | X-ray | 1.65 | A/C | 1-166 | [»] | |
6V9O | X-ray | 1.80 | A/C | 1-166 | [»] | |
6ZJ0 | X-ray | 1.76 | A | 1-166 | [»] | |
6ZL3 | X-ray | 2.03 | A | 1-166 | [»] | |
721P | X-ray | 2.00 | A | 1-166 | [»] | |
7JHP | X-ray | 2.77 | A | 1-166 | [»] | |
821P | X-ray | 1.50 | A | 1-166 | [»] | |
BMRBi | P01112 | |||||
SMRi | P01112 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109501, 644 interactors |
ComplexPortali | CPX-395, GTPase HRAS - Son of sevenless homolog 1 complex |
CORUMi | P01112 |
DIPi | DIP-1050N |
ELMi | P01112 |
IntActi | P01112, 197 interactors |
MINTi | P01112 |
STRINGi | 9606.ENSP00000407586 |
Chemistry databases
BindingDBi | P01112 |
ChEMBLi | CHEMBL2167 |
DrugBanki | DB04315, Guanosine-5'-Diphosphate DB04137, Guanosine-5'-Triphosphate DB02210, Hexane-1,6-Diol DB08751, N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE DB03226, Trifluoroethanol |
DrugCentrali | P01112 |
GuidetoPHARMACOLOGYi | 2822 |
PTM databases
iPTMneti | P01112 |
PhosphoSitePlusi | P01112 |
SwissPalmi | P01112 |
Genetic variation databases
BioMutai | HRAS |
DMDMi | 131869 |
Proteomic databases
CPTACi | CPTAC-1551 CPTAC-1552 |
EPDi | P01112 |
jPOSTi | P01112 |
MassIVEi | P01112 |
PaxDbi | P01112 |
PeptideAtlasi | P01112 |
PRIDEi | P01112 |
ProteomicsDBi | 12698 [P01112-2] 51321 [P01112-1] 51322 [P01112-2] |
Protocols and materials databases
ABCDi | P01112, 5 sequenced antibodies |
Antibodypediai | 22506, 783 antibodies |
DNASUi | 3265 |
Genome annotation databases
Organism-specific databases
CTDi | 3265 |
DisGeNETi | 3265 |
GeneCardsi | HRAS |
GeneReviewsi | HRAS |
HGNCi | HGNC:5173, HRAS |
HPAi | ENSG00000174775, Low tissue specificity |
MalaCardsi | HRAS |
MIMi | 109800, phenotype 163200, phenotype 188470, phenotype 190020, gene 218040, phenotype |
neXtProti | NX_P01112 |
OpenTargetsi | ENSG00000174775 |
Orphaneti | 3071, Costello syndrome 146, Differentiated thyroid carcinoma 2612, Linear nevus sebaceus syndrome 2874, Phakomatosis pigmentokeratotica 79414, Woolly hair nevus |
PharmGKBi | PA29444 |
VEuPathDBi | HostDB:ENSG00000174775.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000155653 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | P01112 |
OMAi | EPDEHIC |
OrthoDBi | 743479at2759 |
PhylomeDBi | P01112 |
TreeFami | TF312796 |
Enzyme and pathway databases
PathwayCommonsi | P01112 |
Reactomei | R-HSA-112412, SOS-mediated signalling R-HSA-1169092, Activation of RAS in B cells R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1250196, SHC1 events in ERBB2 signaling R-HSA-1250347, SHC1 events in ERBB4 signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-167044, Signalling to RAS R-HSA-171007, p38MAPK events R-HSA-179812, GRB2 events in EGFR signaling R-HSA-180336, SHC1 events in EGFR signaling R-HSA-186763, Downstream signal transduction R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-210993, Tie2 Signaling R-HSA-2179392, EGFR Transactivation by Gastrin R-HSA-2424491, DAP12 signaling R-HSA-2428933, SHC-related events triggered by IGF1R R-HSA-2871796, FCERI mediated MAPK activation R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-3928662, EPHB-mediated forward signaling R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5637810, Constitutive Signaling by EGFRvIII R-HSA-5654688, SHC-mediated cascade:FGFR1 R-HSA-5654693, FRS-mediated FGFR1 signaling R-HSA-5654699, SHC-mediated cascade:FGFR2 R-HSA-5654700, FRS-mediated FGFR2 signaling R-HSA-5654704, SHC-mediated cascade:FGFR3 R-HSA-5654706, FRS-mediated FGFR3 signaling R-HSA-5654712, FRS-mediated FGFR4 signaling R-HSA-5654719, SHC-mediated cascade:FGFR4 R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655291, Signaling by FGFR4 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5673000, RAF activation R-HSA-5673001, RAF/MAP kinase cascade R-HSA-5674135, MAP2K and MAPK activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802953, RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-74751, Insulin receptor signalling cascade R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8851805, MET activates RAS signaling R-HSA-8853334, Signaling by FGFR3 fusions in cancer R-HSA-8853338, Signaling by FGFR3 point mutants in cancer R-HSA-9026519, Activated NTRK2 signals through RAS R-HSA-9027284, Erythropoietin activates RAS R-HSA-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9034864, Activated NTRK3 signals through RAS R-HSA-9607240, FLT3 Signaling R-HSA-9634285, Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ R-HSA-9648002, RAS processing R-HSA-9649913, RAS GTPase cycle mutants R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9664565, Signaling by ERBB2 KD Mutants R-HSA-9665348, Signaling by ERBB2 ECD mutants R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants R-HSA-9703465, Signaling by FLT3 fusion proteins R-HSA-9703648, Signaling by FLT3 ITD and TKD mutants |
SABIO-RKi | P01112 |
SignaLinki | P01112 |
SIGNORi | P01112 |
Miscellaneous databases
BioGRID-ORCSi | 3265, 20 hits in 1001 CRISPR screens |
EvolutionaryTracei | P01112 |
GeneWikii | HRAS |
GenomeRNAii | 3265 |
Pharosi | P01112, Tchem |
PROi | PR:P01112 |
RNActi | P01112, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174775, Expressed in skin of abdomen and 239 other tissues |
ExpressionAtlasi | P01112, baseline and differential |
Genevisiblei | P01112, HS |
Family and domain databases
DisProti | DP00153 |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RASH_HUMAN | |
Accessioni | P01112Primary (citable) accession number: P01112 Secondary accession number(s): B5BUA0 Q9UCE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | April 7, 2021 | |
This is version 257 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families