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UniProtKB - P01111 (RASN_HUMAN)

Protein

GTPase NRas

Gene

NRAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Miscellaneous

Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.

Activity regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18GTP1 Publication9
Nucleotide bindingi29 – 30GTP1 Publication2
Nucleotide bindingi57 – 61GTPSequence analysis5
Nucleotide bindingi116 – 119GTP1 Publication4

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • protein-containing complex binding Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-112412 SOS-mediated signalling
R-HSA-1169092 Activation of RAS in B cells
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-167044 Signalling to RAS
R-HSA-171007 p38MAPK events
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-186763 Downstream signal transduction
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-210993 Tie2 Signaling
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2424491 DAP12 signaling
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-6798695 Neutrophil degranulation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9034864 Activated NTRK3 signals through RAS
SignaLinkiP01111
SIGNORiP01111

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase NRas
Alternative name(s):
Transforming protein N-Ras
Gene namesi
Name:NRAS
Synonyms:HRAS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000213281.4
HGNCiHGNC:7989 NRAS
MIMi164790 gene
neXtProtiNX_P01111

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Leukemia, juvenile myelomonocytic (JMML)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
See also OMIM:607785
Noonan syndrome 6 (NS6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
See also OMIM:613224
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06308550T → I in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs267606921EnsemblClinVar.1
Natural variantiVAR_06308660G → E in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs267606920EnsemblClinVar.1
RAS-associated autoimmune leukoproliferative disorder (RALD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.
See also OMIM:614470
Melanocytic nevus syndrome, congenital (CMNS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip.
See also OMIM:137550
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00684761Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma. 5 PublicationsCorresponds to variant dbSNP:rs11554290EnsemblClinVar.1
Melanosis, neurocutaneous (NCMS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma.
See also OMIM:249400
Keratinocytic non-epidermolytic nevus (KNEN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionEpidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood.
See also OMIM:162900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07113034P → L in KNEN. 1 PublicationCorresponds to variant dbSNP:rs397514553EnsemblClinVar.1
Thyroid cancer, non-medullary, 2 (NMTC2)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
See also OMIM:188470

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi164R → A: Loss of GTP-binding activity. 1
Mutagenesisi181C → S: Loss of plasma membrane localization. 1 Publication1

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi4893
GeneReviewsiNRAS
MalaCardsiNRAS
MIMi137550 phenotype
162900 phenotype
188470 phenotype
249400 phenotype
607785 phenotype
613224 phenotype
614470 phenotype
OpenTargetsiENSG00000213281
Orphaneti86834 Juvenile myelomonocytic leukemia
626 Large congenital melanocytic nevus
648 Noonan syndrome
268114 RAS-associated autoimmune leukoproliferative disease
PharmGKBiPA31768

Chemistry databases

ChEMBLiCHEMBL2079845
GuidetoPHARMACOLOGYi2823

Polymorphism and mutation databases

BioMutaiNRAS
DMDMi131883

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000430061 – 186GTPase NRasAdd BLAST186
PropeptideiPRO_0000043007187 – 189Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi181S-palmitoyl cysteine3 Publications1
Modified residuei186Cysteine methyl esterBy similarity1
Lipidationi186S-farnesyl cysteine1 Publication1

Post-translational modificationi

Palmitoylated by the ZDHHC9-GOLGA7 complex (PubMed:16000296). Depalmitoylated by ABHD17A, ABHD17B and ABHD17C (PubMed:26701913). A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi (PubMed:16000296, PubMed:15705808, PubMed:2661017, PubMed:26701913).4 Publications
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiP01111
PaxDbiP01111
PeptideAtlasiP01111
PRIDEiP01111
ProteomicsDBi51320

2D gel databases

OGPiP01111

PTM databases

iPTMnetiP01111
PhosphoSitePlusiP01111
SwissPalmiP01111

Expressioni

Gene expression databases

BgeeiENSG00000213281 Expressed in 217 organ(s), highest expression level in testis
CleanExiHS_NRAS
ExpressionAtlasiP01111 baseline and differential
GenevisibleiP01111 HS

Organism-specific databases

HPAiCAB010157
HPA049830

Interactioni

Subunit structurei

Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi110952, 44 interactors
DIPiDIP-1058N
ELMiP01111
IntActiP01111, 41 interactors
MINTiP01111
STRINGi9606.ENSP00000358548

Chemistry databases

BindingDBiP01111

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01111
SMRiP01111
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01111

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 185Hypervariable regionAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP01111
KOiK07828
OMAiTIEXEQI
OrthoDBiEOG091G0UAU
PhylomeDBiP01111
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET 
        60         70         80         90        100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI 
       110        120        130        140        150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ 
       160        170        180 
GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVVM
Length:189
Mass (Da):21,229
Last modified:July 21, 1986 - v1
Checksum:i6898D3F6815B1EC7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02119412G → C in leukemia. 1 PublicationCorresponds to variant dbSNP:rs121913250EnsemblClinVar.1
Natural variantiVAR_07112912G → D in KNEN and JMML. 2 PublicationsCorresponds to variant dbSNP:rs121913237EnsemblClinVar.1
Natural variantiVAR_06308413G → D in RALD and JMML. 2 PublicationsCorresponds to variant dbSNP:rs121434596EnsemblClinVar.1
Natural variantiVAR_00684513G → R in CMNS and colorectal cancer; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs121434595EnsemblClinVar.1
Natural variantiVAR_07113034P → L in KNEN. 1 PublicationCorresponds to variant dbSNP:rs397514553EnsemblClinVar.1
Natural variantiVAR_06308550T → I in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs267606921EnsemblClinVar.1
Natural variantiVAR_06308660G → E in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs267606920EnsemblClinVar.1
Natural variantiVAR_00684661Q → K in CMNS and NCMS; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913254EnsemblClinVar.1
Natural variantiVAR_00684761Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma. 5 PublicationsCorresponds to variant dbSNP:rs11554290EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02751 mRNA Translation: CAA26529.1
X00642 Genomic DNA Translation: CAA25269.1
X00643 Genomic DNA Translation: CAA25270.1
X00644 Genomic DNA Translation: CAA25271.1
X00645 Genomic DNA Translation: CAA25272.1
L00043
, L00040, L00041, L00042 Genomic DNA Translation: AAA60255.1
AF493919 mRNA Translation: AAM12633.1
AY428630 Genomic DNA Translation: AAQ94397.1
BC005219 mRNA Translation: AAH05219.1
M25898 Genomic DNA Translation: AAA36548.1
X53291, X53292 Genomic DNA Translation: CAA37384.1
K03211, M10055 Genomic DNA Translation: AAA36556.1
X05565 Genomic DNA Translation: CAA29079.1
X07440 Genomic DNA Translation: CAA30320.1
CCDSiCCDS877.1
PIRiA90839 TVHURA
I38149
RefSeqiNP_002515.1, NM_002524.4
UniGeneiHs.486502

Genome annotation databases

EnsembliENST00000369535; ENSP00000358548; ENSG00000213281
GeneIDi4893
KEGGihsa:4893

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NRASbase

NRAS mutation db

NIEHS-SNPs
Wikipedia

RAS proteins entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02751 mRNA Translation: CAA26529.1
X00642 Genomic DNA Translation: CAA25269.1
X00643 Genomic DNA Translation: CAA25270.1
X00644 Genomic DNA Translation: CAA25271.1
X00645 Genomic DNA Translation: CAA25272.1
L00043
, L00040, L00041, L00042 Genomic DNA Translation: AAA60255.1
AF493919 mRNA Translation: AAM12633.1
AY428630 Genomic DNA Translation: AAQ94397.1
BC005219 mRNA Translation: AAH05219.1
M25898 Genomic DNA Translation: AAA36548.1
X53291, X53292 Genomic DNA Translation: CAA37384.1
K03211, M10055 Genomic DNA Translation: AAA36556.1
X05565 Genomic DNA Translation: CAA29079.1
X07440 Genomic DNA Translation: CAA30320.1
CCDSiCCDS877.1
PIRiA90839 TVHURA
I38149
RefSeqiNP_002515.1, NM_002524.4
UniGeneiHs.486502

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N9CNMR-A1-17[»]
3CONX-ray1.65A1-172[»]
5UHVX-ray1.67A1-166[»]
ProteinModelPortaliP01111
SMRiP01111
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110952, 44 interactors
DIPiDIP-1058N
ELMiP01111
IntActiP01111, 41 interactors
MINTiP01111
STRINGi9606.ENSP00000358548

Chemistry databases

BindingDBiP01111
ChEMBLiCHEMBL2079845
GuidetoPHARMACOLOGYi2823

PTM databases

iPTMnetiP01111
PhosphoSitePlusiP01111
SwissPalmiP01111

Polymorphism and mutation databases

BioMutaiNRAS
DMDMi131883

2D gel databases

OGPiP01111

Proteomic databases

EPDiP01111
PaxDbiP01111
PeptideAtlasiP01111
PRIDEiP01111
ProteomicsDBi51320

Protocols and materials databases

DNASUi4893
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369535; ENSP00000358548; ENSG00000213281
GeneIDi4893
KEGGihsa:4893

Organism-specific databases

CTDi4893
DisGeNETi4893
EuPathDBiHostDB:ENSG00000213281.4
GeneCardsiNRAS
GeneReviewsiNRAS
HGNCiHGNC:7989 NRAS
HPAiCAB010157
HPA049830
MalaCardsiNRAS
MIMi137550 phenotype
162900 phenotype
164790 gene
188470 phenotype
249400 phenotype
607785 phenotype
613224 phenotype
614470 phenotype
neXtProtiNX_P01111
OpenTargetsiENSG00000213281
Orphaneti86834 Juvenile myelomonocytic leukemia
626 Large congenital melanocytic nevus
648 Noonan syndrome
268114 RAS-associated autoimmune leukoproliferative disease
PharmGKBiPA31768
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP01111
KOiK07828
OMAiTIEXEQI
OrthoDBiEOG091G0UAU
PhylomeDBiP01111
TreeFamiTF312796

Enzyme and pathway databases

ReactomeiR-HSA-112412 SOS-mediated signalling
R-HSA-1169092 Activation of RAS in B cells
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-167044 Signalling to RAS
R-HSA-171007 p38MAPK events
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-186763 Downstream signal transduction
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-210993 Tie2 Signaling
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2424491 DAP12 signaling
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-6798695 Neutrophil degranulation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9034864 Activated NTRK3 signals through RAS
SignaLinkiP01111
SIGNORiP01111

Miscellaneous databases

ChiTaRSiNRAS human
EvolutionaryTraceiP01111
GeneWikiiNeuroblastoma_RAS_viral_oncogene_homolog
GenomeRNAii4893
PROiPR:P01111
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213281 Expressed in 217 organ(s), highest expression level in testis
CleanExiHS_NRAS
ExpressionAtlasiP01111 baseline and differential
GenevisibleiP01111 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASN_HUMAN
AccessioniPrimary (citable) accession number: P01111
Secondary accession number(s): Q14971, Q15104, Q15282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 215 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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