UniProtKB - P01111 (RASN_HUMAN)
Protein
GTPase NRas
Gene
NRAS
Organism
Homo sapiens (Human)
Status
Functioni
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.1 Publication
Miscellaneous
Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.
Catalytic activityi
- EC:3.6.5.2By similarity
Activity regulationi
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | GTP1 Publication | 9 | |
Nucleotide bindingi | 29 – 30 | GTP1 Publication | 2 | |
Nucleotide bindingi | 57 – 61 | GTPSequence analysis | 5 | |
Nucleotide bindingi | 116 – 119 | GTP1 Publication | 4 |
GO - Molecular functioni
- GDP binding Source: GO_Central
- GTPase activity Source: UniProtKB
- GTP binding Source: GO_Central
- protein-containing complex binding Source: MGI
GO - Biological processi
- MAPK cascade Source: Reactome
- neutrophil degranulation Source: Reactome
- positive regulation of endothelial cell proliferation Source: BHF-UCL
- Ras protein signal transduction Source: UniProtKB
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P01111 |
Reactomei | R-HSA-112412, SOS-mediated signalling R-HSA-1169092, Activation of RAS in B cells R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1250196, SHC1 events in ERBB2 signaling R-HSA-1250347, SHC1 events in ERBB4 signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-167044, Signalling to RAS R-HSA-171007, p38MAPK events R-HSA-179812, GRB2 events in EGFR signaling R-HSA-180336, SHC1 events in EGFR signaling R-HSA-186763, Downstream signal transduction R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-210993, Tie2 Signaling R-HSA-2179392, EGFR Transactivation by Gastrin R-HSA-2424491, DAP12 signaling R-HSA-2428933, SHC-related events triggered by IGF1R R-HSA-2871796, FCERI mediated MAPK activation R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5637810, Constitutive Signaling by EGFRvIII R-HSA-5654688, SHC-mediated cascade:FGFR1 R-HSA-5654693, FRS-mediated FGFR1 signaling R-HSA-5654699, SHC-mediated cascade:FGFR2 R-HSA-5654700, FRS-mediated FGFR2 signaling R-HSA-5654704, SHC-mediated cascade:FGFR3 R-HSA-5654706, FRS-mediated FGFR3 signaling R-HSA-5654712, FRS-mediated FGFR4 signaling R-HSA-5654719, SHC-mediated cascade:FGFR4 R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655291, Signaling by FGFR4 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5673000, RAF activation R-HSA-5673001, RAF/MAP kinase cascade R-HSA-5674135, MAP2K and MAPK activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6798695, Neutrophil degranulation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802953, RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-74751, Insulin receptor signalling cascade R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8851805, MET activates RAS signaling R-HSA-8853334, Signaling by FGFR3 fusions in cancer R-HSA-8853338, Signaling by FGFR3 point mutants in cancer R-HSA-9026519, Activated NTRK2 signals through RAS R-HSA-9027284, Erythropoietin activates RAS R-HSA-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9034864, Activated NTRK3 signals through RAS R-HSA-9607240, FLT3 Signaling R-HSA-9634285, Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ R-HSA-9648002, RAS processing R-HSA-9649913, RAS GTPase cycle mutants R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9664565, Signaling by ERBB2 KD Mutants R-HSA-9665348, Signaling by ERBB2 ECD mutants R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants |
SignaLinki | P01111 |
SIGNORi | P01111 |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase NRas (EC:3.6.5.2By similarity)Alternative name(s): Transforming protein N-Ras |
Gene namesi | Name:NRAS Synonyms:HRAS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000213281.4 |
HGNCi | HGNC:7989, NRAS |
MIMi | 164790, gene |
neXtProti | NX_P01111 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Lipid-anchor 2 Publications; Cytoplasmic side 2 Publications
Golgi apparatus
- Golgi apparatus membrane 2 Publications; Lipid-anchor 2 Publications
Note: Shuttles between the plasma membrane and the Golgi apparatus.2 Publications
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: CACAO
- Golgi membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- membrane Source: UniProtKB
- tertiary granule membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Leukemia, juvenile myelomonocytic (JMML)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071129 | 12 | G → D in KNEN and JMML. 2 PublicationsCorresponds to variant dbSNP:rs121913237EnsemblClinVar. | 1 | |
Natural variantiVAR_063084 | 13 | G → D in RALD and JMML. 2 PublicationsCorresponds to variant dbSNP:rs121434596EnsemblClinVar. | 1 |
Noonan syndrome 6 (NS6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063085 | 50 | T → I in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs267606921EnsemblClinVar. | 1 | |
Natural variantiVAR_063086 | 60 | G → E in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs267606920EnsemblClinVar. | 1 |
RAS-associated autoimmune leukoproliferative disorder (RALD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063084 | 13 | G → D in RALD and JMML. 2 PublicationsCorresponds to variant dbSNP:rs121434596EnsemblClinVar. | 1 |
Melanocytic nevus syndrome, congenital (CMNS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006845 | 13 | G → R in CMNS and colorectal cancer; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs121434595EnsemblClinVar. | 1 | |
Natural variantiVAR_006846 | 61 | Q → K in CMNS and NCMS; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913254EnsemblClinVar. | 1 | |
Natural variantiVAR_006847 | 61 | Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma; impaired GTP hydrolysis activity, trapping NRAS in a constitutive GTP-bound active conformation; promotes melanomagenesis. 6 PublicationsCorresponds to variant dbSNP:rs11554290EnsemblClinVar. | 1 |
Melanosis, neurocutaneous (NCMS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006846 | 61 | Q → K in CMNS and NCMS; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913254EnsemblClinVar. | 1 |
Keratinocytic non-epidermolytic nevus (KNEN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionEpidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071129 | 12 | G → D in KNEN and JMML. 2 PublicationsCorresponds to variant dbSNP:rs121913237EnsemblClinVar. | 1 | |
Natural variantiVAR_071130 | 34 | P → L in KNEN. 1 PublicationCorresponds to variant dbSNP:rs397514553EnsemblClinVar. | 1 |
Thyroid cancer, non-medullary, 2 (NMTC2)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006847 | 61 | Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma; impaired GTP hydrolysis activity, trapping NRAS in a constitutive GTP-bound active conformation; promotes melanomagenesis. 6 PublicationsCorresponds to variant dbSNP:rs11554290EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 89 | S → A: Abolished phosphorylation by STK19. 1 Publication | 1 | |
Mutagenesisi | 164 | R → A: Loss of GTP-binding activity. | 1 | |
Mutagenesisi | 181 | C → S: Loss of plasma membrane localization. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Proto-oncogeneOrganism-specific databases
DisGeNETi | 4893 |
GeneReviewsi | NRAS |
MalaCardsi | NRAS |
MIMi | 137550, phenotype 162900, phenotype 188470, phenotype 249400, phenotype 607785, phenotype 613224, phenotype 614470, phenotype |
OpenTargetsi | ENSG00000213281 |
Orphaneti | 146, Differentiated thyroid carcinoma 86834, Juvenile myelomonocytic leukemia 626, Large congenital melanocytic nevus 2612, Linear nevus sebaceus syndrome 411533, NON RARE IN EUROPE: Melanoma 648, Noonan syndrome 268114, RAS-associated autoimmune leukoproliferative disease 357194, Selection of therapeutic option in colorectal cancer 544260, Selection of therapeutic option in melanoma |
PharmGKBi | PA31768 |
Miscellaneous databases
Pharosi | P01111, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2079845 |
GuidetoPHARMACOLOGYi | 2823 |
Polymorphism and mutation databases
BioMutai | NRAS |
DMDMi | 131883 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000043006 | 1 – 186 | GTPase NRasAdd BLAST | 186 | |
PropeptideiPRO_0000043007 | 187 – 189 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 35 | (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL1 Publication | 1 | |
Modified residuei | 89 | Phosphoserine; by STK191 Publication | 1 | |
Cross-linki | 170 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Lipidationi | 181 | S-palmitoyl cysteine3 Publications | 1 | |
Lipidationi | 186 | S-farnesyl cysteine1 Publication | 1 |
Post-translational modificationi
Palmitoylated by the ZDHHC9-GOLGA7 complex (PubMed:16000296). Depalmitoylated by ABHD17A, ABHD17B and ABHD17C (PubMed:26701913). A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi (PubMed:16000296, PubMed:15705808, PubMed:2661017, PubMed:26701913).4 Publications
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).By similarity
Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.1 Publication
Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.1 Publication
(Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.1 Publication
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation, Ubl conjugationProteomic databases
CPTACi | CPTAC-1549 |
EPDi | P01111 |
jPOSTi | P01111 |
MassIVEi | P01111 |
PaxDbi | P01111 |
PeptideAtlasi | P01111 |
PRIDEi | P01111 |
ProteomicsDBi | 51320 |
2D gel databases
OGPi | P01111 |
PTM databases
iPTMneti | P01111 |
MetOSitei | P01111 |
PhosphoSitePlusi | P01111 |
SwissPalmi | P01111 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213281, Expressed in testis and 233 other tissues |
ExpressionAtlasi | P01111, baseline and differential |
Genevisiblei | P01111, HS |
Organism-specific databases
HPAi | ENSG00000213281, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (active GTP-bound form preferentially) with RGS14 (By similarity).
Interacts (active GTP-bound form) with RASSF7 (PubMed:21278800).
By similarity1 PublicationBinary interactionsi
Hide detailsP01111
Protein-protein interaction databases
BioGRIDi | 110952, 630 interactors |
DIPi | DIP-1058N |
ELMi | P01111 |
IntActi | P01111, 61 interactors |
MINTi | P01111 |
STRINGi | 9606.ENSP00000358548 |
Chemistry databases
BindingDBi | P01111 |
Miscellaneous databases
RNActi | P01111, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P01111 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01111 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 185 | Hypervariable regionAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 32 – 40 | Effector region | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000158947 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | P01111 |
OMAi | RIPCKLM |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P01111 |
TreeFami | TF312796 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01111-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVVM
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021194 | 12 | G → C in leukemia. 1 PublicationCorresponds to variant dbSNP:rs121913250EnsemblClinVar. | 1 | |
Natural variantiVAR_071129 | 12 | G → D in KNEN and JMML. 2 PublicationsCorresponds to variant dbSNP:rs121913237EnsemblClinVar. | 1 | |
Natural variantiVAR_063084 | 13 | G → D in RALD and JMML. 2 PublicationsCorresponds to variant dbSNP:rs121434596EnsemblClinVar. | 1 | |
Natural variantiVAR_006845 | 13 | G → R in CMNS and colorectal cancer; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs121434595EnsemblClinVar. | 1 | |
Natural variantiVAR_071130 | 34 | P → L in KNEN. 1 PublicationCorresponds to variant dbSNP:rs397514553EnsemblClinVar. | 1 | |
Natural variantiVAR_063085 | 50 | T → I in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs267606921EnsemblClinVar. | 1 | |
Natural variantiVAR_063086 | 60 | G → E in NS6; hypermorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs267606920EnsemblClinVar. | 1 | |
Natural variantiVAR_006846 | 61 | Q → K in CMNS and NCMS; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913254EnsemblClinVar. | 1 | |
Natural variantiVAR_006847 | 61 | Q → R in CMNS, NCMS, KNEN and NMTC2; also found in lung carcinoma cell and melanoma; impaired GTP hydrolysis activity, trapping NRAS in a constitutive GTP-bound active conformation; promotes melanomagenesis. 6 PublicationsCorresponds to variant dbSNP:rs11554290EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02751 mRNA Translation: CAA26529.1 X00642 Genomic DNA Translation: CAA25269.1 X00643 Genomic DNA Translation: CAA25270.1 X00644 Genomic DNA Translation: CAA25271.1 X00645 Genomic DNA Translation: CAA25272.1 L00043 , L00040, L00041, L00042 Genomic DNA Translation: AAA60255.1 AF493919 mRNA Translation: AAM12633.1 AY428630 Genomic DNA Translation: AAQ94397.1 BC005219 mRNA Translation: AAH05219.1 M25898 Genomic DNA Translation: AAA36548.1 X53291, X53292 Genomic DNA Translation: CAA37384.1 K03211, M10055 Genomic DNA Translation: AAA36556.1 X05565 Genomic DNA Translation: CAA29079.1 X07440 Genomic DNA Translation: CAA30320.1 |
CCDSi | CCDS877.1 |
PIRi | A90839, TVHURA I38149 |
RefSeqi | NP_002515.1, NM_002524.4 |
Genome annotation databases
Ensembli | ENST00000369535; ENSP00000358548; ENSG00000213281 |
GeneIDi | 4893 |
KEGGi | hsa:4893 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NRASbase NRAS mutation db |
NIEHS-SNPs |
Wikipedia RAS proteins entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02751 mRNA Translation: CAA26529.1 X00642 Genomic DNA Translation: CAA25269.1 X00643 Genomic DNA Translation: CAA25270.1 X00644 Genomic DNA Translation: CAA25271.1 X00645 Genomic DNA Translation: CAA25272.1 L00043 , L00040, L00041, L00042 Genomic DNA Translation: AAA60255.1 AF493919 mRNA Translation: AAM12633.1 AY428630 Genomic DNA Translation: AAQ94397.1 BC005219 mRNA Translation: AAH05219.1 M25898 Genomic DNA Translation: AAA36548.1 X53291, X53292 Genomic DNA Translation: CAA37384.1 K03211, M10055 Genomic DNA Translation: AAA36556.1 X05565 Genomic DNA Translation: CAA29079.1 X07440 Genomic DNA Translation: CAA30320.1 |
CCDSi | CCDS877.1 |
PIRi | A90839, TVHURA I38149 |
RefSeqi | NP_002515.1, NM_002524.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2N9C | NMR | - | A | 1-17 | [»] | |
3CON | X-ray | 1.65 | A | 1-172 | [»] | |
5UHV | X-ray | 1.67 | A | 1-166 | [»] | |
6E6H | X-ray | 1.99 | A | 1-166 | [»] | |
6MPP | NMR | - | B | 55-64 | [»] | |
6ULI | X-ray | 1.88 | C | 10-18 | [»] | |
6ULK | X-ray | 1.90 | C | 10-19 | [»] | |
6ULN | X-ray | 2.01 | C | 10-18 | [»] | |
6ULR | X-ray | 3.20 | C | 10-18 | [»] | |
6UON | X-ray | 3.50 | C/F | 10-19 | [»] | |
6WGH | X-ray | 1.65 | A/B | 1-170 | [»] | |
6ZIO | X-ray | 1.55 | A/B | 1-172 | [»] | |
6ZIR | X-ray | 1.90 | A | 1-172 | [»] | |
6ZIZ | X-ray | 1.78 | A/B | 1-172 | [»] | |
SMRi | P01111 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110952, 630 interactors |
DIPi | DIP-1058N |
ELMi | P01111 |
IntActi | P01111, 61 interactors |
MINTi | P01111 |
STRINGi | 9606.ENSP00000358548 |
Chemistry databases
BindingDBi | P01111 |
ChEMBLi | CHEMBL2079845 |
GuidetoPHARMACOLOGYi | 2823 |
PTM databases
iPTMneti | P01111 |
MetOSitei | P01111 |
PhosphoSitePlusi | P01111 |
SwissPalmi | P01111 |
Polymorphism and mutation databases
BioMutai | NRAS |
DMDMi | 131883 |
2D gel databases
OGPi | P01111 |
Proteomic databases
CPTACi | CPTAC-1549 |
EPDi | P01111 |
jPOSTi | P01111 |
MassIVEi | P01111 |
PaxDbi | P01111 |
PeptideAtlasi | P01111 |
PRIDEi | P01111 |
ProteomicsDBi | 51320 |
Protocols and materials databases
ABCDi | P01111, 1 sequenced antibody |
Antibodypediai | 4118, 550 antibodies |
DNASUi | 4893 |
Genome annotation databases
Ensembli | ENST00000369535; ENSP00000358548; ENSG00000213281 |
GeneIDi | 4893 |
KEGGi | hsa:4893 |
Organism-specific databases
CTDi | 4893 |
DisGeNETi | 4893 |
EuPathDBi | HostDB:ENSG00000213281.4 |
GeneCardsi | NRAS |
GeneReviewsi | NRAS |
HGNCi | HGNC:7989, NRAS |
HPAi | ENSG00000213281, Low tissue specificity |
MalaCardsi | NRAS |
MIMi | 137550, phenotype 162900, phenotype 164790, gene 188470, phenotype 249400, phenotype 607785, phenotype 613224, phenotype 614470, phenotype |
neXtProti | NX_P01111 |
OpenTargetsi | ENSG00000213281 |
Orphaneti | 146, Differentiated thyroid carcinoma 86834, Juvenile myelomonocytic leukemia 626, Large congenital melanocytic nevus 2612, Linear nevus sebaceus syndrome 411533, NON RARE IN EUROPE: Melanoma 648, Noonan syndrome 268114, RAS-associated autoimmune leukoproliferative disease 357194, Selection of therapeutic option in colorectal cancer 544260, Selection of therapeutic option in melanoma |
PharmGKBi | PA31768 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000158947 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | P01111 |
OMAi | RIPCKLM |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P01111 |
TreeFami | TF312796 |
Enzyme and pathway databases
PathwayCommonsi | P01111 |
Reactomei | R-HSA-112412, SOS-mediated signalling R-HSA-1169092, Activation of RAS in B cells R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1250196, SHC1 events in ERBB2 signaling R-HSA-1250347, SHC1 events in ERBB4 signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-167044, Signalling to RAS R-HSA-171007, p38MAPK events R-HSA-179812, GRB2 events in EGFR signaling R-HSA-180336, SHC1 events in EGFR signaling R-HSA-186763, Downstream signal transduction R-HSA-1963640, GRB2 events in ERBB2 signaling R-HSA-210993, Tie2 Signaling R-HSA-2179392, EGFR Transactivation by Gastrin R-HSA-2424491, DAP12 signaling R-HSA-2428933, SHC-related events triggered by IGF1R R-HSA-2871796, FCERI mediated MAPK activation R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5637810, Constitutive Signaling by EGFRvIII R-HSA-5654688, SHC-mediated cascade:FGFR1 R-HSA-5654693, FRS-mediated FGFR1 signaling R-HSA-5654699, SHC-mediated cascade:FGFR2 R-HSA-5654700, FRS-mediated FGFR2 signaling R-HSA-5654704, SHC-mediated cascade:FGFR3 R-HSA-5654706, FRS-mediated FGFR3 signaling R-HSA-5654712, FRS-mediated FGFR4 signaling R-HSA-5654719, SHC-mediated cascade:FGFR4 R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655291, Signaling by FGFR4 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5673000, RAF activation R-HSA-5673001, RAF/MAP kinase cascade R-HSA-5674135, MAP2K and MAPK activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6798695, Neutrophil degranulation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802953, RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-74751, Insulin receptor signalling cascade R-HSA-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8851805, MET activates RAS signaling R-HSA-8853334, Signaling by FGFR3 fusions in cancer R-HSA-8853338, Signaling by FGFR3 point mutants in cancer R-HSA-9026519, Activated NTRK2 signals through RAS R-HSA-9027284, Erythropoietin activates RAS R-HSA-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9034864, Activated NTRK3 signals through RAS R-HSA-9607240, FLT3 Signaling R-HSA-9634285, Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ R-HSA-9648002, RAS processing R-HSA-9649913, RAS GTPase cycle mutants R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9664565, Signaling by ERBB2 KD Mutants R-HSA-9665348, Signaling by ERBB2 ECD mutants R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants |
SignaLinki | P01111 |
SIGNORi | P01111 |
Miscellaneous databases
BioGRID-ORCSi | 4893, 61 hits in 850 CRISPR screens |
ChiTaRSi | NRAS, human |
EvolutionaryTracei | P01111 |
GeneWikii | Neuroblastoma_RAS_viral_oncogene_homolog |
GenomeRNAii | 4893 |
Pharosi | P01111, Tchem |
PROi | PR:P01111 |
RNActi | P01111, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213281, Expressed in testis and 233 other tissues |
ExpressionAtlasi | P01111, baseline and differential |
Genevisiblei | P01111, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RASN_HUMAN | |
Accessioni | P01111Primary (citable) accession number: P01111 Secondary accession number(s): Q14971, Q15104, Q15282 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | December 2, 2020 | |
This is version 233 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations