Myc proto-oncogene protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activating transcription factor binding Source: MGI
• cis-regulatory region sequence-specific DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation."
    Armstrong L., Lako M., van Herpe I., Evans J., Saretzki G., Hole N.
    Mech. Dev. 121:1509-1522(2004) [PubMed] [Europe PMC] [Abstract]
• core promoter sequence-specific DNA binding Source: MGI
• DNA binding Source: MGIInferred from direct assayⁱ
  • "Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis."
    Hurlin P.J., Zhou Z.Q., Toyo-oka K., Ota S., Walker W.L., Hirotsune S., Wynshaw-Boris A.
    EMBO J 22:4584-4596(2003) [PubMed] [Europe PMC] [Abstract]
  • "Miz1 is required for early embryonic development during gastrulation."
    Adhikary S., Peukert K., Karsunky H., Beuger V., Lutz W., Elsaesser H.-P., Moeroey T., Eilers M.
    Mol. Cell. Biol. 23:7648-7657(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity Source: UniProtKB
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
• double-stranded DNA binding Source: MGI
• E-box binding Source: UniProtKB
• protein-containing complex binding Source: UniProtKB
• protein dimerization activity Source: InterPro
• repressing transcription factor binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma."
    Bonetti P., Davoli T., Sironi C., Amati B., Pelicci P.G., Colombo E.
    J Cell Biol 182:19-26(2008) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGI
• transcription factor binding Source: MGI
• ubiquitin protein ligase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.11

    "TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells."
    Sato T., Okumura F., Ariga T., Hatakeyama S.
    J. Cell Sci. 125:1544-1555(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: MUTAGENESIS OF THR-58 AND SER-62, INTERACTION WITH TRIM6, UBIQUITINATION.

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGIInferred from direct assayⁱ
  • "c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL."
    Maclean K.H., Keller U.B., Rodriguez-Galindo C., Nilsson J.A., Cleveland J.L.
    Mol Cell Biol 23:7256-7270(2003) [PubMed] [Europe PMC] [Abstract]
• amino acid transport Source: MGI
• B cell apoptotic process Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death."
    de Alboran I.M., Baena E., Martinez-A C.
    Cell Death Differ 11:61-68(2004) [PubMed] [Europe PMC] [Abstract]
• branching involved in ureteric bud morphogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "C-myc as a modulator of renal stem/progenitor cell population."
    Couillard M., Trudel M.
    Dev Dyn 238:405-414(2009) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Myc deletion rescues Apc deficiency in the small intestine."
    Sansom O.J., Meniel V.S., Muncan V., Phesse T.J., Wilkins J.A., Reed K.R., Vass J.K., Athineos D., Clevers H., Clarke A.R.
    Nature 446:676-679(2007) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Myc deletion rescues Apc deficiency in the small intestine."
    Sansom O.J., Meniel V.S., Muncan V., Phesse T.J., Wilkins J.A., Reed K.R., Vass J.K., Athineos D., Clevers H., Clarke A.R.
    Nature 446:676-679(2007) [PubMed] [Europe PMC] [Abstract]
• cell cycle arrest Source: MGI
• cell population proliferation Source: MGI
• cellular iron ion homeostasis Source: UniProtKB
• cellular response to DNA damage stimulus Source: MGIInferred from direct assayⁱ
  • "p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication."
    Cannell I.G., Kong Y.W., Johnston S.J., Chen M.L., Collins H.M., Dobbyn H.C., Elia A., Kress T.R., Dickens M., Clemens M.J., Heery D.M., Gaestel M., Eilers M., Willis A.E., Bushell M.
    Proc Natl Acad Sci U S A 107:5375-5380(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to drug Source: UniProtKBInferred from direct assayⁱ
  • "Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine."
    Hoglund A., Nilsson L.M., Forshell L.P., Maclean K.H., Nilsson J.A.
    Blood 113:4281-4288(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: MGI
• cellular response to interferon-alpha Source: MGIInferred from direct assayⁱ
  • "Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-alpha-induced stress response."
    Ehninger A., Boch T., Uckelmann H., Essers M.A., Mudder K., Sleckman B.P., Trumpp A.
    Blood 123:3909-3913(2014) [PubMed] [Europe PMC] [Abstract]
• chromatin remodeling Source: UniProtKB
• chromosome organization Source: UniProtKB
• detection of mechanical stimulus involved in sensory perception of sound Source: MGIInferred from mutant phenotypeⁱ
  • "Neural crest cell deficiency of c-myc causes skull and hearing defects."
    Wei K., Chen J., Akrami K., Galbraith G.C., Lopez I.A., Chen F.
    Genesis 45:382-390(2007) [PubMed] [Europe PMC] [Abstract]
• DNA-templated transcription, initiation Source: MGI
• ERK1 and ERK2 cascade Source: MGI
• glucose metabolic process Source: MGI
• inner mitochondrial membrane organization Source: MGI
• intrinsic apoptotic signaling pathway in response to DNA damage Source: MGIInferred from direct assayⁱ
  • "c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL."
    Maclean K.H., Keller U.B., Rodriguez-Galindo C., Nilsson J.A., Cleveland J.L.
    Mol Cell Biol 23:7256-7270(2003) [PubMed] [Europe PMC] [Abstract]
• lactic acid secretion Source: MGI
• MAPK cascade Source: UniProtKB
• middle ear morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Neural crest cell deficiency of c-myc causes skull and hearing defects."
    Wei K., Chen J., Akrami K., Galbraith G.C., Lopez I.A., Chen F.
    Genesis 45:382-390(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell death Source: MGI
• negative regulation of cell division Source: UniProtKB
• negative regulation of fibroblast proliferation Source: MGI
• negative regulation of gene expression Source: MGI
• negative regulation of glucose import Source: MGI
• negative regulation of monocyte differentiation Source: UniProtKB
• negative regulation of protein binding Source: MGIInferred from direct assayⁱ
  • "Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc."
    Alter-Koltunoff M., Goren S., Nousbeck J., Feng C.G., Sher A., Ozato K., Azriel A., Levi B.Z.
    J Biol Chem 283:2724-2733(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "c-Myc represses the murine Nramp1 promoter."
    Bowen H., Biggs T.E., Baker S.T., Phillips E., Perry V.H., Mann D.A., Barton C.H.
    Biochem Soc Trans 30:774-777(2002) [PubMed] [Europe PMC] [Abstract]
• pigmentation Source: MGIInferred from mutant phenotypeⁱ
  • "Neural crest cell deficiency of c-myc causes skull and hearing defects."
    Wei K., Chen J., Akrami K., Galbraith G.C., Lopez I.A., Chen F.
    Genesis 45:382-390(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic signaling pathway Source: MGIInferred from direct assayⁱ
  • "c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL."
    Maclean K.H., Keller U.B., Rodriguez-Galindo C., Nilsson J.A., Cleveland J.L.
    Mol Cell Biol 23:7256-7270(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ATP biosynthetic process Source: MGI
• positive regulation of B cell apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis."
    Eischen C.M., Roussel M.F., Korsmeyer S.J., Cleveland J.L.
    Mol Cell Biol 21:7653-7662(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of catalytic activity Source: MGIInferred from mutant phenotypeⁱ
  • "c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells."
    Hou Y., Okamoto C., Okada K., Kawao N., Kawata S., Ueshima S., Matsuo O.
    Cardiovasc Res 75:186-194(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell cycle Source: MGI
• positive regulation of cell population proliferation Source: MGIInferred from direct assayⁱ
  • "Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor."
    Widlund H.R., Horstmann M.A., Price E.R., Cui J., Lessnick S.L., Wu M., He X., Fisher D.E.
    J Cell Biol 158:1079-1087(2002) [PubMed] [Europe PMC] [Abstract]
  • "c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL."
    Maclean K.H., Keller U.B., Rodriguez-Galindo C., Nilsson J.A., Cleveland J.L.
    Mol Cell Biol 23:7256-7270(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cellular respiration Source: MGI
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
• positive regulation of DNA binding Source: MGI
• positive regulation of DNA biosynthetic process Source: UniProtKB
• positive regulation of DNA methylation Source: MGI
• positive regulation of epithelial cell proliferation Source: UniProtKB
• positive regulation of fibroblast proliferation Source: UniProtKB
• positive regulation of gene expression Source: MGI
• positive regulation of glial cell proliferation Source: MGI
• positive regulation of glycolytic process Source: MGI
• positive regulation of mesenchymal cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "C-myc as a modulator of renal stem/progenitor cell population."
    Couillard M., Trudel M.
    Dev Dyn 238:405-414(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of metanephric cap mesenchymal cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "C-myc as a modulator of renal stem/progenitor cell population."
    Couillard M., Trudel M.
    Dev Dyn 238:405-414(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitochondrial membrane potential Source: MGI
• positive regulation of oxidative phosphorylation Source: MGI
• positive regulation of response to DNA damage stimulus Source: UniProtKB
• positive regulation of smooth muscle cell migration Source: MGI
• positive regulation of smooth muscle cell proliferation Source: MGI
• positive regulation of telomerase activity Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Myc activates telomerase."
    Wang J., Xie L.Y., Allan S., Beach D., Hannon G.J.
    Genes Dev 12:1769-1774(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • "Myc activates telomerase."
    Wang J., Xie L.Y., Allan S., Beach D., Hannon G.J.
    Genes Dev 12:1769-1774(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity."
    Zhang Q., Spears E., Boone D.N., Li Z., Gregory M.A., Hann S.R.
    Proc Natl Acad Sci U S A 110:978-983(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription initiation from RNA polymerase II promoter Source: CACAOInferred from direct assayⁱ
  • "Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors."
    Yang Z., Augustin J., Hu J., Jiang H.
    PLoS One 10:e0145336-e0145336(2015) [PubMed] [Europe PMC] [Abstract]
• protein-DNA complex disassembly Source: MGI
• protein processing Source: MGIInferred from mutant phenotypeⁱ
  • "c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death."
    de Alboran I.M., Baena E., Martinez-A C.
    Cell Death Differ 11:61-68(2004) [PubMed] [Europe PMC] [Abstract]
• pyruvate transport Source: MGI
• re-entry into mitotic cell cycle Source: MGI
• regulation of apoptotic process Source: MGIInferred from direct assayⁱ
  • "Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor."
    Widlund H.R., Horstmann M.A., Price E.R., Cui J., Lessnick S.L., Wu M., He X., Fisher D.E.
    J Cell Biol 158:1079-1087(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: MGIInferred from direct assayⁱ
  • "Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis."
    Eischen C.M., Woo D., Roussel M.F., Cleveland J.L.
    Mol Cell Biol 21:5063-5070(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of mitotic cell cycle Source: MGI
• regulation of oxidative phosphorylation Source: MGI
• regulation of somatic stem cell population maintenance Source: UniProtKBInferred from direct assayⁱ
  • Ref.13

    "TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network."
    Seruggia D., Oti M., Tripathi P., Canver M.C., LeBlanc L., Di Giammartino D.C., Bullen M.J., Nefzger C.M., Sun Y.B.Y., Farouni R., Polo J.M., Pinello L., Apostolou E., Kim J., Orkin S.H., Das P.P.
    Mol. Cell 74:1148.E7-1163.E7(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• regulation of telomere maintenance Source: UniProtKB
• regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.13

    "TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network."
    Seruggia D., Oti M., Tripathi P., Canver M.C., LeBlanc L., Di Giammartino D.C., Bullen M.J., Nefzger C.M., Sun Y.B.Y., Farouni R., Polo J.M., Pinello L., Apostolou E., Kim J., Orkin S.H., Das P.P.
    Mol. Cell 74:1148.E7-1163.E7(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to alkaloid Source: MGIInferred from mutant phenotypeⁱ
  • "c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death."
    de Alboran I.M., Baena E., Martinez-A C.
    Cell Death Differ 11:61-68(2004) [PubMed] [Europe PMC] [Abstract]
• response to gamma radiation Source: UniProtKB
• response to radiation Source: MGIInferred from direct assayⁱ
  • "c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL."
    Maclean K.H., Keller U.B., Rodriguez-Galindo C., Nilsson J.A., Cleveland J.L.
    Mol Cell Biol 23:7256-7270(2003) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation."
    Rajan S., Chu Pham Dang H., Djambazian H., Zuzan H., Fedyshyn Y., Ketela T., Moffat J., Hudson T.J., Sladek R.
    Physiol Genomics 44:183-197(2012) [PubMed] [Europe PMC] [Abstract]
• skeletal system morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Neural crest cell deficiency of c-myc causes skull and hearing defects."
    Wei K., Chen J., Akrami K., Galbraith G.C., Lopez I.A., Chen F.
    Genesis 45:382-390(2007) [PubMed] [Europe PMC] [Abstract]
• transcription, DNA-templated Source: MGI
• transcription by RNA polymerase II Source: MGI
• transformation of host cell by virus Source: MGI
• Wnt signaling pathway Source: MGIInferred from direct assayⁱ
  • "A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors."
    Miranda-Carboni G.A., Krum S.A., Yee K., Nava M., Deng Q.E., Pervin S., Collado-Hidalgo A., Galic Z., Zack J.A., Nakayama K., Nakayama K.I., Lane T.F.
    Genes Dev 22:3121-3134(2008) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological useⁱ

Mutagenesis

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• activating transcription factor binding Source: MGI
• protein dimerization activity Source: InterPro
• repressing transcription factor binding Source: MGI
• transcription factor binding Source: MGI
• ubiquitin protein ligase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.11

    "TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells."
    Sato T., Okumura F., Ariga T., Hatakeyama S.
    J. Cell Sci. 125:1544-1555(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: MUTAGENESIS OF THR-58 AND SER-62, INTERACTION WITH TRIM6, UBIQUITINATION.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MPLNVNFTNR NYDLDYDSVQ PYFICDEEEN FYHQQQQSEL QPPAPSEDIW 
        60         70         80         90        100
KKFELLPTPP LSPSRRSGLC SPSYVAVATS FSPREDDDGG GGNFSTADQL 
       110        120        130        140        150
EMMTELLGGD MVNQSFICDP DDETFIKNII IQDCMWSGFS AAAKLVSEKL 
       160        170        180        190        200
ASYQAARKDS TSLSPARGHS VCSTSSLYLQ DLTAAASECI DPSVVFPYPL 
       210        220        230        240        250
NDSSSPKSCT SSDSTAFSPS SDSLLSSESS PRASPEPLVL HEETPPTTSS 
       260        270        280        290        300
DSEEEQEDEE EIDVVSVEKR QTPAKRSESG SSPSRGHSKP PHSPLVLKRC 
       310        320        330        340        350
HVSTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCSSPRSSDT 
       360        370        380        390        400
EENDKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT 
       410        420        430 
AYILSIQADE HKLTSEKDLL RKRREQLKHK LEQLRNSGA             

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot