UniProtKB - P01108 (MYC_MOUSE)
Myc proto-oncogene protein
Myc
Functioni
GO - Molecular functioni
- activating transcription factor binding Source: MGI
- cis-regulatory region sequence-specific DNA binding Source: MGI
- core promoter sequence-specific DNA binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- double-stranded DNA binding Source: MGI
- E-box binding Source: UniProtKB
- protein-containing complex binding Source: UniProtKB
- protein dimerization activity Source: InterPro
- repressing transcription factor binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- transcription factor binding Source: MGI
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- amino acid transport Source: MGI
- B cell apoptotic process Source: MGI
- branching involved in ureteric bud morphogenesis Source: UniProtKB
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
- cell cycle arrest Source: MGI
- cell population proliferation Source: MGI
- cellular iron ion homeostasis Source: UniProtKB
- cellular response to DNA damage stimulus Source: MGI
- cellular response to drug Source: UniProtKB
- cellular response to hypoxia Source: MGI
- cellular response to interferon-alpha Source: MGI
- chromatin remodeling Source: UniProtKB
- chromosome organization Source: UniProtKB
- detection of mechanical stimulus involved in sensory perception of sound Source: MGI
- DNA-templated transcription, initiation Source: MGI
- ERK1 and ERK2 cascade Source: MGI
- glucose metabolic process Source: MGI
- inner mitochondrial membrane organization Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- lactic acid secretion Source: MGI
- MAPK cascade Source: UniProtKB
- middle ear morphogenesis Source: MGI
- negative regulation of cell death Source: MGI
- negative regulation of cell division Source: UniProtKB
- negative regulation of fibroblast proliferation Source: MGI
- negative regulation of gene expression Source: MGI
- negative regulation of glucose import Source: MGI
- negative regulation of monocyte differentiation Source: UniProtKB
- negative regulation of protein binding Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- pigmentation Source: MGI
- positive regulation of apoptotic signaling pathway Source: MGI
- positive regulation of ATP biosynthetic process Source: MGI
- positive regulation of B cell apoptotic process Source: MGI
- positive regulation of catalytic activity Source: MGI
- positive regulation of cell cycle Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cellular respiration Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- positive regulation of DNA binding Source: MGI
- positive regulation of DNA biosynthetic process Source: UniProtKB
- positive regulation of DNA methylation Source: MGI
- positive regulation of epithelial cell proliferation Source: UniProtKB
- positive regulation of fibroblast proliferation Source: UniProtKB
- positive regulation of gene expression Source: MGI
- positive regulation of glial cell proliferation Source: MGI
- positive regulation of glycolytic process Source: MGI
- positive regulation of mesenchymal cell proliferation Source: UniProtKB
- positive regulation of metanephric cap mesenchymal cell proliferation Source: UniProtKB
- positive regulation of mitochondrial membrane potential Source: MGI
- positive regulation of oxidative phosphorylation Source: MGI
- positive regulation of response to DNA damage stimulus Source: UniProtKB
- positive regulation of smooth muscle cell migration Source: MGI
- positive regulation of smooth muscle cell proliferation Source: MGI
- positive regulation of telomerase activity Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription initiation from RNA polymerase II promoter Source: CACAO
- protein-DNA complex disassembly Source: MGI
- protein processing Source: MGI
- pyruvate transport Source: MGI
- re-entry into mitotic cell cycle Source: MGI
- regulation of apoptotic process Source: MGI
- regulation of gene expression Source: MGI
- regulation of mitotic cell cycle Source: MGI
- regulation of oxidative phosphorylation Source: MGI
- regulation of somatic stem cell population maintenance Source: UniProtKB
- regulation of telomere maintenance Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- response to alkaloid Source: MGI
- response to gamma radiation Source: UniProtKB
- response to radiation Source: MGI
- skeletal muscle cell differentiation Source: MGI
- skeletal system morphogenesis Source: MGI
- transcription, DNA-templated Source: MGI
- transcription by RNA polymerase II Source: MGI
- transformation of host cell by virus Source: MGI
- Wnt signaling pathway Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-5689880, Ub-specific processing proteases R-MMU-8866911, TFAP2 (AP-2) family regulates transcription of cell cycle factors R-MMU-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: Myc proto-oncogene proteinAlternative name(s): Proto-oncogene c-Myc Transcription factor p64 |
Gene namesi | Name:Myc |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97250, Myc |
Subcellular locationi
Nucleus
- nucleoplasm By similarity
- nucleolus By similarity
Cytoskeleton
- spindle Source: MGI
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nuclear body Source: MGI
- nuclear chromatin Source: MGI
- nuclear euchromatin Source: BHF-UCL
- nucleolus Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- axon Source: MGI
- cytoplasm Source: MGI
- perinuclear region of cytoplasm Source: UniProtKB
- protein-containing complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Biotechnological usei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 58 | T → A: Does not affect interaction with TRIM6. 1 Publication | 1 | |
Mutagenesisi | 62 | S → A: Does not affect interaction with TRIM6. 1 Publication | 1 | |
Mutagenesisi | 329 | S → A: Reduces phosphorylation by PIM2 by 60%, and decreases the transcriptional activity of MYC. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogenePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127296 | 1 – 439 | Myc proto-oncogene proteinAdd BLAST | 439 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 52 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 58 | Phosphothreonine; by GSK3; alternateBy similarity | 1 | |
Glycosylationi | 58 | O-linked (GlcNAc) threonine; alternateBy similarity | 1 | |
Modified residuei | 62 | Phosphoserine; by DYRK2, GSK3 and CDK2By similarity | 1 | |
Modified residuei | 71 | PhosphoserineBy similarity | 1 | |
Modified residuei | 144 | N6-acetyllysine; by PCAF; alternateBy similarity | 1 | |
Cross-linki | 144 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 149 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 149 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 158 | N6-acetyllysine; by PCAFBy similarity | 1 | |
Modified residuei | 162 | PhosphoserineBy similarity | 1 | |
Modified residuei | 275 | N6-acetyllysine; by PCAFBy similarity | 1 | |
Modified residuei | 293 | PhosphoserineBy similarity | 1 | |
Cross-linki | 298 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 317 | N6-acetyllysine; by PCAFBy similarity | 1 | |
Modified residuei | 323 | N6-acetyllysine; by PCAFBy similarity | 1 | |
Modified residuei | 329 | Phosphoserine; by PIM2; in vitro1 Publication | 1 | |
Modified residuei | 371 | N6-acetyllysine; by PCAFBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P01108 |
MaxQBi | P01108 |
PaxDbi | P01108 |
PeptideAtlasi | P01108 |
PRIDEi | P01108 |
PTM databases
GlyGeni | P01108, 1 site |
iPTMneti | P01108 |
PhosphoSitePlusi | P01108 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000022346, Expressed in ectoplacental cone and 298 other tissues |
ExpressionAtlasi | P01108, baseline and differential |
Genevisiblei | P01108, MM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).
Interacts with TAF1C and SPAG9.
Interacts with PARP10.
Interacts with KDM5A and KDM5B.
Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7.
Interacts with PIM2 (PubMed:18438430).
Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity (By similarity).
Interacts with TRIM6 (PubMed:22328504).
Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity).
Interacts with CIP2A; leading to the stabilization of MYC (By similarity).
By similarity3 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- activating transcription factor binding Source: MGI
- protein dimerization activity Source: InterPro
- repressing transcription factor binding Source: MGI
- transcription factor binding Source: MGI
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 201635, 32 interactors |
ComplexPortali | CPX-1144, FOXO3-MYC complex CPX-744, c-MYC-BIN1 complex CPX-97, Transcriptional activator Myc-Max complex |
CORUMi | P01108 |
DIPi | DIP-1064N |
IntActi | P01108, 17 interactors |
STRINGi | 10090.ENSMUSP00000022971 |
Miscellaneous databases
RNActi | P01108, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 354 – 406 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 413 – 434 | Leucine-zipperAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 37 | Poly-Gln | 4 | |
Compositional biasi | 89 – 92 | Poly-Gly | 4 |
Phylogenomic databases
eggNOGi | KOG2483, Eukaryota |
GeneTreei | ENSGT00940000155285 |
HOGENOMi | CLU_052560_0_0_1 |
InParanoidi | P01108 |
OMAi | IHNDMER |
PhylomeDBi | P01108 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003327, Myc-LZ IPR002418, Tscrpt_reg_Myc IPR012682, Tscrpt_reg_Myc_N |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF02344, Myc-LZ, 1 hit PF01056, Myc_N, 1 hit |
PIRSFi | PIRSF001705, Myc_protein, 1 hit |
PRINTSi | PR00044, LEUZIPPRMYC |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPLNVNFTNR NYDLDYDSVQ PYFICDEEEN FYHQQQQSEL QPPAPSEDIW
60 70 80 90 100
KKFELLPTPP LSPSRRSGLC SPSYVAVATS FSPREDDDGG GGNFSTADQL
110 120 130 140 150
EMMTELLGGD MVNQSFICDP DDETFIKNII IQDCMWSGFS AAAKLVSEKL
160 170 180 190 200
ASYQAARKDS TSLSPARGHS VCSTSSLYLQ DLTAAASECI DPSVVFPYPL
210 220 230 240 250
NDSSSPKSCT SSDSTAFSPS SDSLLSSESS PRASPEPLVL HEETPPTTSS
260 270 280 290 300
DSEEEQEDEE EIDVVSVEKR QTPAKRSESG SSPSRGHSKP PHSPLVLKRC
310 320 330 340 350
HVSTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCSSPRSSDT
360 370 380 390 400
EENDKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT
410 420 430
AYILSIQADE HKLTSEKDLL RKRREQLKHK LEQLRNSGA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WID3 | F8WID3_MOUSE | Myc proto-oncogene protein | Myc | 454 | Annotation score: | ||
A0A087WSQ0 | A0A087WSQ0_MOUSE | Myc proto-oncogene protein | Myc | 453 | Annotation score: | ||
F6PX41 | F6PX41_MOUSE | Myc proto-oncogene protein | Myc | 453 | Annotation score: | ||
E0CZD1 | E0CZD1_MOUSE | Myc proto-oncogene protein | Myc | 32 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | E → D in K00683 (PubMed:6412145).Curated | 1 | |
Sequence conflicti | 101 | E → Q in AAB59728 (PubMed:6321164).Curated | 1 | |
Sequence conflicti | 284 | S → F in AAB59728 (PubMed:6321164).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00039, L00038 Genomic DNA Translation: AAB59728.1 X01023 mRNA Translation: CAA25508.1 AK087961 mRNA Translation: BAC40060.1 AK133952 mRNA Translation: BAE21948.1 AK145084 mRNA Translation: BAE26228.1 BC006728 mRNA Translation: AAH06728.2 Different initiation. K00683 Genomic DNA No translation available. |
CCDSi | CCDS49615.1 |
PIRi | A93337, TVMS |
RefSeqi | NP_001170823.1, NM_001177352.1 NP_001170824.1, NM_001177353.1 NP_001170825.1, NM_001177354.1 |
Genome annotation databases
Ensembli | ENSMUST00000159327; ENSMUSP00000124758; ENSMUSG00000022346 ENSMUST00000160009; ENSMUSP00000123852; ENSMUSG00000022346 ENSMUST00000161976; ENSMUSP00000123821; ENSMUSG00000022346 |
GeneIDi | 17869 |
KEGGi | mmu:17869 |
UCSCi | uc007vyh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00039, L00038 Genomic DNA Translation: AAB59728.1 X01023 mRNA Translation: CAA25508.1 AK087961 mRNA Translation: BAC40060.1 AK133952 mRNA Translation: BAE21948.1 AK145084 mRNA Translation: BAE26228.1 BC006728 mRNA Translation: AAH06728.2 Different initiation. K00683 Genomic DNA No translation available. |
CCDSi | CCDS49615.1 |
PIRi | A93337, TVMS |
RefSeqi | NP_001170823.1, NM_001177352.1 NP_001170824.1, NM_001177353.1 NP_001170825.1, NM_001177354.1 |
3D structure databases
SMRi | P01108 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201635, 32 interactors |
ComplexPortali | CPX-1144, FOXO3-MYC complex CPX-744, c-MYC-BIN1 complex CPX-97, Transcriptional activator Myc-Max complex |
CORUMi | P01108 |
DIPi | DIP-1064N |
IntActi | P01108, 17 interactors |
STRINGi | 10090.ENSMUSP00000022971 |
PTM databases
GlyGeni | P01108, 1 site |
iPTMneti | P01108 |
PhosphoSitePlusi | P01108 |
Proteomic databases
EPDi | P01108 |
MaxQBi | P01108 |
PaxDbi | P01108 |
PeptideAtlasi | P01108 |
PRIDEi | P01108 |
Protocols and materials databases
Antibodypediai | 3520, 4059 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000159327; ENSMUSP00000124758; ENSMUSG00000022346 ENSMUST00000160009; ENSMUSP00000123852; ENSMUSG00000022346 ENSMUST00000161976; ENSMUSP00000123821; ENSMUSG00000022346 |
GeneIDi | 17869 |
KEGGi | mmu:17869 |
UCSCi | uc007vyh.2, mouse |
Organism-specific databases
CTDi | 4609 |
MGIi | MGI:97250, Myc |
Phylogenomic databases
eggNOGi | KOG2483, Eukaryota |
GeneTreei | ENSGT00940000155285 |
HOGENOMi | CLU_052560_0_0_1 |
InParanoidi | P01108 |
OMAi | IHNDMER |
PhylomeDBi | P01108 |
Enzyme and pathway databases
Reactomei | R-MMU-5689880, Ub-specific processing proteases R-MMU-8866911, TFAP2 (AP-2) family regulates transcription of cell cycle factors R-MMU-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
BioGRID-ORCSi | 17869, 7 hits in 19 CRISPR screens |
ChiTaRSi | Myc, mouse |
PROi | PR:P01108 |
RNActi | P01108, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022346, Expressed in ectoplacental cone and 298 other tissues |
ExpressionAtlasi | P01108, baseline and differential |
Genevisiblei | P01108, MM |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003327, Myc-LZ IPR002418, Tscrpt_reg_Myc IPR012682, Tscrpt_reg_Myc_N |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF02344, Myc-LZ, 1 hit PF01056, Myc_N, 1 hit |
PIRSFi | PIRSF001705, Myc_protein, 1 hit |
PRINTSi | PR00044, LEUZIPPRMYC |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYC_MOUSE | |
Accessioni | P01108Primary (citable) accession number: P01108 Secondary accession number(s): P70247, Q3UM70, Q61422 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | December 2, 2020 | |
This is version 210 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot