UniProtKB - P01106 (MYC_HUMAN)
Protein
Myc proto-oncogene protein
Gene
MYC
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).2 Publications
GO - Molecular functioni
- activating transcription factor binding Source: CAFA
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
- E-box binding Source: UniProtKB
- protein-containing complex binding Source: UniProtKB
- protein dimerization activity Source: InterPro
- proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- repressing transcription factor binding Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- transcription factor binding Source: UniProtKB
GO - Biological processi
- beta-catenin-TCF complex assembly Source: Reactome
- branching involved in ureteric bud morphogenesis Source: UniProtKB
- cell cycle arrest Source: UniProtKB
- cellular iron ion homeostasis Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to drug Source: UniProtKB
- cellular response to hypoxia Source: CAFA
- cellular response to UV Source: UniProtKB
- chromatin remodeling Source: UniProtKB
- chromosome organization Source: UniProtKB
- cytokine-mediated signaling pathway Source: Reactome
- energy reserve metabolic process Source: UniProtKB
- ERK1 and ERK2 cascade Source: CAFA
- fibroblast apoptotic process Source: UniProtKB
- G1/S transition of mitotic cell cycle Source: Reactome
- MAPK cascade Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cell division Source: UniProtKB
- negative regulation of fibroblast proliferation Source: UniProtKB
- negative regulation of monocyte differentiation Source: UniProtKB
- negative regulation of stress-activated MAPK cascade Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- Notch signaling pathway Source: Reactome
- oxygen transport Source: UniProtKB
- positive regulation of cell proliferation Source: CAFA
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- positive regulation of DNA biosynthetic process Source: UniProtKB
- positive regulation of DNA methylation Source: BHF-UCL
- positive regulation of epithelial cell proliferation Source: UniProtKB
- positive regulation of fibroblast proliferation Source: UniProtKB
- positive regulation of gene expression Source: CAFA
- positive regulation of mesenchymal cell proliferation Source: UniProtKB
- positive regulation of metanephric cap mesenchymal cell proliferation Source: UniProtKB
- positive regulation of response to DNA damage stimulus Source: UniProtKB
- positive regulation of telomerase activity Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- protein deubiquitination Source: Reactome
- protein-DNA complex disassembly Source: CAFA
- regulation of gene expression Source: MGI
- regulation of telomere maintenance Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: Reactome
- response to drug Source: UniProtKB
- response to gamma radiation Source: UniProtKB
- response to growth factor Source: UniProtKB
Keywordsi
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
| BioCyci | MetaCyc:ENSG00000136997-MONOMER |
| Reactomei | R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689880 Ub-specific processing proteases R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-9018519 Estrogen-dependent gene expression |
| SignaLinki | P01106 |
| SIGNORi | P01106 |
Names & Taxonomyi
| Protein namesi | Recommended name: Myc proto-oncogene proteinAlternative name(s): Class E basic helix-loop-helix protein 39 Short name: bHLHe39 Proto-oncogene c-Myc Transcription factor p64 |
| Gene namesi | Name:MYC Synonyms:BHLHE39 |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000136997.15 |
| HGNCi | HGNC:7553 MYC |
| MIMi | 190080 gene |
| neXtProti | NX_P01106 |
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.1 Publication
Burkitt lymphoma (BL)2 Publications
The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
Disease descriptionA form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass.
See also OMIM:113970Biotechnological usei
POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 58 | T → A: Impairs interaction with FBXW7 and subsequent degradation by the proteasome. Normal inhibition of Ras-induced senescence. 4 Publications | 1 | |
| Mutagenesisi | 62 | S → A: Impairs interaction with FBXW7 and subsequent degradation by the proteasome. Impaired inhibition of Ras-induced senescence. Abolishes phosphorylation by DYRK2, and subsequent phosphorylation by GSK3B at Thr-58. 5 Publications | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
| DisGeNETi | 4609 |
| MalaCardsi | MYC |
| MIMi | 113970 phenotype |
| OpenTargetsi | ENSG00000136997 |
| Orphaneti | 543 Burkitt lymphoma 480541 High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement 99861 Precursor T-cell acute lymphoblastic leukemia |
| PharmGKBi | PA31353 |
Chemistry databases
| ChEMBLi | CHEMBL1250348 |
| DrugBanki | DB08813 Nadroparin |
Polymorphism and mutation databases
| BioMutai | MYC |
| DMDMi | 127619 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000127293 | 1 – 439 | Myc proto-oncogene proteinAdd BLAST | 439 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 6 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 8 | Phosphothreonine; by RAF; in vitro1 Publication | 1 | |
| Cross-linki | 52 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
| Modified residuei | 58 | Phosphothreonine; by GSK3; alternateCombined sources3 Publications | 1 | |
| GlycosylationiCAR_000033 | 58 | O-linked (GlcNAc) threonine; alternate1 Publication | 1 | |
| Modified residuei | 62 | Phosphoserine; by DYRK2, GSK3 and CDK2Combined sources6 Publications | 1 | |
| Modified residuei | 71 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 143 | N6-acetyllysine; by PCAF; alternate1 Publication | 1 | |
| Cross-linki | 143 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
| Modified residuei | 148 | N6-acetyllysine; alternateCombined sources | 1 | |
| Cross-linki | 148 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
| Modified residuei | 157 | N6-acetyllysine; by PCAF1 Publication | 1 | |
| Modified residuei | 161 | PhosphoserineCombined sources | 1 | |
| Modified residuei | 275 | N6-acetyllysine; by PCAF1 Publication | 1 | |
| Modified residuei | 293 | PhosphoserineCombined sources | 1 | |
| Cross-linki | 298 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
| Modified residuei | 317 | N6-acetyllysine; by PCAF1 Publication | 1 | |
| Modified residuei | 323 | N6-acetyllysine; by PCAF1 Publication | 1 | |
| Modified residuei | 329 | Phosphoserine; by PIM2; in vitroBy similarity | 1 | |
| Modified residuei | 371 | N6-acetyllysine; by PCAF1 Publication | 1 |
Post-translational modificationi
Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.By similarity6 Publications
Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:25775507,PubMed:17558397). Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).By similarity7 Publications
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
| EPDi | P01106 |
| MaxQBi | P01106 |
| PaxDbi | P01106 |
| PeptideAtlasi | P01106 |
| PRIDEi | P01106 |
| ProteomicsDBi | 51318 51319 [P01106-2] |
2D gel databases
| SWISS-2DPAGEi | P01106 |
PTM databases
| GlyConnecti | 426 |
| iPTMneti | P01106 |
| PhosphoSitePlusi | P01106 |
| UniCarbKBi | P01106 |
Expressioni
Gene expression databases
| Bgeei | ENSG00000136997 Expressed in 216 organ(s), highest expression level in thoracic mammary gland |
| CleanExi | HS_MYC |
| ExpressionAtlasi | P01106 baseline and differential |
| Genevisiblei | P01106 HS |
Organism-specific databases
| HPAi | CAB000084 CAB010307 HPA055893 HPA066556 |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (PubMed:9680483). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7(PubMed:25775507, PubMed:17558397). Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (PubMed:25956029). Interacts with CIP2A; leading to the stabilization of MYC (PubMed:17632056).By similarity11 Publications
Binary interactionsi
GO - Molecular functioni
- activating transcription factor binding Source: CAFA
- protein dimerization activity Source: InterPro
- repressing transcription factor binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
| BioGridi | 110694, 621 interactors |
| ComplexPortali | CPX-1123 FOXO3-MYC complex CPX-514 c-MYC-BIN1 complex CPX-91 Transcriptional activator Myc-Max complex |
| CORUMi | P01106 |
| DIPi | DIP-28143N |
| IntActi | P01106, 717 interactors |
| MINTi | P01106 |
| STRINGi | 9606.ENSP00000367207 |
Chemistry databases
| BindingDBi | P01106 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| DisProti | DP00260 |
| ProteinModelPortali | P01106 |
| SMRi | P01106 |
| ModBasei | Search... |
| MobiDBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | P01106 |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 354 – 406 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 413 – 434 | Leucine-zipperAdd BLAST | 22 |
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Compositional biasi | 33 – 37 | Poly-Gln | 5 | |
| Compositional biasi | 88 – 91 | Poly-Gly | 4 |
Phylogenomic databases
| eggNOGi | ENOG410IFSM Eukaryota ENOG41124Q3 LUCA |
| GeneTreei | ENSGT00510000046414 |
| HOGENOMi | HOG000043075 |
| HOVERGENi | HBG000472 |
| InParanoidi | P01106 |
| KOi | K04377 |
| PhylomeDBi | P01106 |
| TreeFami | TF106001 |
Family and domain databases
| CDDi | cd00083 HLH, 1 hit |
| Gene3Di | 4.10.280.10, 1 hit |
| InterProi | View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003327 Myc-LZ IPR002418 Tscrpt_reg_Myc IPR012682 Tscrpt_reg_Myc_N |
| Pfami | View protein in Pfam PF00010 HLH, 1 hit PF02344 Myc-LZ, 1 hit PF01056 Myc_N, 1 hit |
| PIRSFi | PIRSF001705 Myc_protein, 1 hit |
| PRINTSi | PR00044 LEUZIPPRMYC |
| SMARTi | View protein in SMART SM00353 HLH, 1 hit |
| SUPFAMi | SSF47459 SSF47459, 1 hit |
| PROSITEi | View protein in PROSITE PS50888 BHLH, 1 hit |
Sequences (2+)i
Sequence statusi: Complete.
This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P01106-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW
60 70 80 90 100
KKFELLPTPP LSPSRRSGLC SPSYVAVTPF SLRGDNDGGG GSFSTADQLE
110 120 130 140 150
MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA
160 170 180 190 200
SYQAARKDSG SPNPARGHSV CSTSSLYLQD LSAAASECID PSVVFPYPLN
210 220 230 240 250
DSSSPKSCAS QDSSAFSPSS DSLLSSTESS PQGSPEPLVL HEETPPTTSS
260 270 280 290 300
DSEEEQEDEE EIDVVSVEKR QAPGKRSESG SPSAGGHSKP PHSPLVLKRC
310 320 330 340 350
HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT
360 370 380 390 400
EENVKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT
410 420 430
AYILSVQAEE QKLISEEDLL RKRREQLKHK LEQLRNSCA
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| A0A087WUS5 | A0A087WUS5_HUMAN | Myc proto-oncogene protein | MYC | 454 | Annotation score: | ||
| Q14899 | Q14899_HUMAN | Myc proto-oncogene protein | MYC MRTL | 114 | Annotation score: | ||
| H0YBT0 | H0YBT0_HUMAN | Myc proto-oncogene protein | MYC | 453 | Annotation score: | ||
| A0A087WVR4 | A0A087WVR4_HUMAN | Myc proto-oncogene protein | MYC | 454 | Annotation score: | ||
| A0A0B4J1R1 | A0A0B4J1R1_HUMAN | Myc proto-oncogene protein | MYC hCG_15917 | 257 | Annotation score: | ||
| H0YBG3 | H0YBG3_HUMAN | Myc proto-oncogene protein | MYC | 184 | Annotation score: | ||
| E5RGD7 | E5RGD7_HUMAN | Myc proto-oncogene protein | MYC | 59 | Annotation score: | ||
| Q16591 | Q16591_HUMAN | Myc protein | MYC | 188 | Annotation score: |
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
|---|---|---|---|---|---|
| Sequence conflicti | 6 – 7 | SF → TI no nucleotide entry (PubMed:6419122).Curated | 2 | ||
| Sequence conflicti | 10 | R → K no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 56 | L → LL no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 62 | S → P in CAA25288 (PubMed:6547209).Curated | 1 | ||
| Sequence conflicti | 88 | G → D no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 92 | S → N no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 114 | S → N no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 120 | D → G no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 171 | C → S no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 203 | S → R no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 230 | S → A no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 240 | L → F no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Sequence conflicti | 245 | P → S no nucleotide entry (PubMed:6419122).Curated | 1 | ||
| Isoform 2 (identifier: P01106-2) | |||||
| Sequence conflicti | 2 | D → N in BAA01374 (PubMed:6547209).Curated | 1 | ||
| Sequence conflicti | 6 | V → E in BAA01374 (PubMed:6547209).Curated | 1 | ||
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_016327 | 11 | N → S1 PublicationCorresponds to variant dbSNP:rs4645959Ensembl. | 1 | |
| Natural variantiVAR_063384 | 39 | E → D in a Burkitt lymphoma symple. 2 PublicationsCorresponds to variant dbSNP:rs121918684Ensembl. | 1 | |
| Natural variantiVAR_063385 | 57 | P → S in a Burkitt lymphoma sample. 1 PublicationCorresponds to variant dbSNP:rs28933407Ensembl. | 1 | |
| Natural variantiVAR_063386 | 59 | P → A in a Burkitt lymphoma sample. 1 PublicationCorresponds to variant dbSNP:rs121918685Ensembl. | 1 | |
| Natural variantiVAR_063387 | 86 | N → T in a Burkitt lymphoma sample. 1 PublicationCorresponds to variant dbSNP:rs121918683Ensembl. | 1 | |
| Natural variantiVAR_016328 | 160 | G → C1 PublicationCorresponds to variant dbSNP:rs4645960Ensembl. | 1 | |
| Natural variantiVAR_016329 | 170 | V → I1 PublicationCorresponds to variant dbSNP:rs4645961Ensembl. | 1 | |
| Natural variantiVAR_016330 | 322 | A → V1 PublicationCorresponds to variant dbSNP:rs4645968Ensembl. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_037813 | 1 | M → MDFFRVVENQQPPATM in isoform 2. 1 Publication | 1 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00058, L00057 Genomic DNA Translation: AAA59882.1 K00535, K00534 Genomic DNA Translation: AAA59880.1 K00535, K00534 Genomic DNA Translation: ABW69847.1 X00196, X00198 Genomic DNA Translation: CAA25015.2 X00364 Genomic DNA Translation: CAA25106.1 V00568 mRNA Translation: CAA23831.1 K01906, K01905 Genomic DNA Translation: AAA59881.1 K02276 mRNA Translation: AAA36340.1 X00676 Genomic DNA Translation: CAA25288.1 D10493 Genomic DNA Translation: BAA01374.2 D10493 Genomic DNA Translation: BAA01375.1 BT019768 mRNA Translation: AAV38573.1 AY214166 Genomic DNA Translation: AAO21131.1 AK312883 mRNA Translation: BAG35731.1 AC103819 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92098.1 BC000141 mRNA Translation: AAH00141.2 BC000917 mRNA Translation: AAH00917.2 BC058901 mRNA Translation: AAH58901.2 M13929 mRNA Translation: AAA88092.1 |
| CCDSi | CCDS6359.2 [P01106-2] |
| PIRi | A01349 TVHUM A01350 TVHUT |
| RefSeqi | NP_002458.2, NM_002467.4 [P01106-2] |
| UniGenei | Hs.202453 |
Genome annotation databases
| Ensembli | ENST00000377970; ENSP00000367207; ENSG00000136997 [P01106-1] ENST00000613283; ENSP00000479618; ENSG00000136997 [P01106-2] |
| GeneIDi | 4609 |
| KEGGi | hsa:4609 |
| UCSCi | uc064qdj.1 human [P01106-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangement, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
| Atlas of Genetics and Cytogenetics in Oncology and Haematology |
| NIEHS-SNPs |
| Wikipedia Myc entry |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00058, L00057 Genomic DNA Translation: AAA59882.1 K00535, K00534 Genomic DNA Translation: AAA59880.1 K00535, K00534 Genomic DNA Translation: ABW69847.1 X00196, X00198 Genomic DNA Translation: CAA25015.2 X00364 Genomic DNA Translation: CAA25106.1 V00568 mRNA Translation: CAA23831.1 K01906, K01905 Genomic DNA Translation: AAA59881.1 K02276 mRNA Translation: AAA36340.1 X00676 Genomic DNA Translation: CAA25288.1 D10493 Genomic DNA Translation: BAA01374.2 D10493 Genomic DNA Translation: BAA01375.1 BT019768 mRNA Translation: AAV38573.1 AY214166 Genomic DNA Translation: AAO21131.1 AK312883 mRNA Translation: BAG35731.1 AC103819 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92098.1 BC000141 mRNA Translation: AAH00141.2 BC000917 mRNA Translation: AAH00917.2 BC058901 mRNA Translation: AAH58901.2 M13929 mRNA Translation: AAA88092.1 |
| CCDSi | CCDS6359.2 [P01106-2] |
| PIRi | A01349 TVHUM A01350 TVHUT |
| RefSeqi | NP_002458.2, NM_002467.4 [P01106-2] |
| UniGenei | Hs.202453 |
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 1A93 | NMR | - | A | 406-434 | [»] | |
| 1EE4 | X-ray | 2.10 | C/D/E/F | 320-328 | [»] | |
| 1MV0 | NMR | - | A | 55-68 | [»] | |
| 1NKP | X-ray | 1.80 | A/D | 353-434 | [»] | |
| 2A93 | NMR | - | A | 406-434 | [»] | |
| 2OR9 | X-ray | 2.70 | P | 410-419 | [»] | |
| 4Y7R | X-ray | 1.90 | B | 260-267 | [»] | |
| 5I4Z | X-ray | 1.95 | A/B | 350-439 | [»] | |
| 5I50 | X-ray | 2.70 | A/B | 350-439 | [»] | |
| 6C4U | X-ray | 2.60 | G/H/I/J/K/L | 54-62 | [»] | |
| DisProti | DP00260 | |||||
| ProteinModelPortali | P01106 | |||||
| SMRi | P01106 | |||||
| ModBasei | Search... | |||||
| MobiDBi | Search... | |||||
Protein-protein interaction databases
| BioGridi | 110694, 621 interactors |
| ComplexPortali | CPX-1123 FOXO3-MYC complex CPX-514 c-MYC-BIN1 complex CPX-91 Transcriptional activator Myc-Max complex |
| CORUMi | P01106 |
| DIPi | DIP-28143N |
| IntActi | P01106, 717 interactors |
| MINTi | P01106 |
| STRINGi | 9606.ENSP00000367207 |
Chemistry databases
| BindingDBi | P01106 |
| ChEMBLi | CHEMBL1250348 |
| DrugBanki | DB08813 Nadroparin |
PTM databases
| GlyConnecti | 426 |
| iPTMneti | P01106 |
| PhosphoSitePlusi | P01106 |
| UniCarbKBi | P01106 |
Polymorphism and mutation databases
| BioMutai | MYC |
| DMDMi | 127619 |
2D gel databases
| SWISS-2DPAGEi | P01106 |
Proteomic databases
| EPDi | P01106 |
| MaxQBi | P01106 |
| PaxDbi | P01106 |
| PeptideAtlasi | P01106 |
| PRIDEi | P01106 |
| ProteomicsDBi | 51318 51319 [P01106-2] |
Protocols and materials databases
| DNASUi | 4609 |
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
| Ensembli | ENST00000377970; ENSP00000367207; ENSG00000136997 [P01106-1] ENST00000613283; ENSP00000479618; ENSG00000136997 [P01106-2] |
| GeneIDi | 4609 |
| KEGGi | hsa:4609 |
| UCSCi | uc064qdj.1 human [P01106-1] |
Organism-specific databases
| CTDi | 4609 |
| DisGeNETi | 4609 |
| EuPathDBi | HostDB:ENSG00000136997.15 |
| GeneCardsi | MYC |
| H-InvDBi | HIX0007784 |
| HGNCi | HGNC:7553 MYC |
| HPAi | CAB000084 CAB010307 HPA055893 HPA066556 |
| MalaCardsi | MYC |
| MIMi | 113970 phenotype 190080 gene |
| neXtProti | NX_P01106 |
| OpenTargetsi | ENSG00000136997 |
| Orphaneti | 543 Burkitt lymphoma 480541 High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement 99861 Precursor T-cell acute lymphoblastic leukemia |
| PharmGKBi | PA31353 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | ENOG410IFSM Eukaryota ENOG41124Q3 LUCA |
| GeneTreei | ENSGT00510000046414 |
| HOGENOMi | HOG000043075 |
| HOVERGENi | HBG000472 |
| InParanoidi | P01106 |
| KOi | K04377 |
| PhylomeDBi | P01106 |
| TreeFami | TF106001 |
Enzyme and pathway databases
| BioCyci | MetaCyc:ENSG00000136997-MONOMER |
| Reactomei | R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689880 Ub-specific processing proteases R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-9018519 Estrogen-dependent gene expression |
| SignaLinki | P01106 |
| SIGNORi | P01106 |
Miscellaneous databases
| ChiTaRSi | MYC human |
| EvolutionaryTracei | P01106 |
| GeneWikii | Myc |
| GenomeRNAii | 4609 |
| PROi | PR:P01106 |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000136997 Expressed in 216 organ(s), highest expression level in thoracic mammary gland |
| CleanExi | HS_MYC |
| ExpressionAtlasi | P01106 baseline and differential |
| Genevisiblei | P01106 HS |
Family and domain databases
| CDDi | cd00083 HLH, 1 hit |
| Gene3Di | 4.10.280.10, 1 hit |
| InterProi | View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003327 Myc-LZ IPR002418 Tscrpt_reg_Myc IPR012682 Tscrpt_reg_Myc_N |
| Pfami | View protein in Pfam PF00010 HLH, 1 hit PF02344 Myc-LZ, 1 hit PF01056 Myc_N, 1 hit |
| PIRSFi | PIRSF001705 Myc_protein, 1 hit |
| PRINTSi | PR00044 LEUZIPPRMYC |
| SMARTi | View protein in SMART SM00353 HLH, 1 hit |
| SUPFAMi | SSF47459 SSF47459, 1 hit |
| PROSITEi | View protein in PROSITE PS50888 BHLH, 1 hit |
| ProtoNeti | Search... |
Entry informationi
| Entry namei | MYC_HUMAN | |
| Accessioni | P01106Primary (citable) accession number: P01106 Secondary accession number(s): A8WFE7, P01107, Q14026 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
| Last sequence update: | August 13, 1987 | |
| Last modified: | November 7, 2018 | |
| This is version 238 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
