MYC

Functionⁱ

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).2 Publications

GO - Molecular functionⁱ

activating transcription factor binding
Source: CAFA
Inferred from physical interactionⁱ
- 19160485
DNA binding Source: UniProtKB
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9924025
E-box binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18818310
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18987311
protein dimerization activity Source: InterPro
repressing transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15674325
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10723141
RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25956029
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10723141
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15674325

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

beta-catenin-TCF complex assembly Source: Reactome
branching involved in ureteric bud morphogenesis Source: UniProtKB
canonical Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 21533051
cell cycle arrest
Source: UniProtKB
Inferred from direct assayⁱ
- 10962037
cellular iron ion homeostasis
Source: UniProtKB
Inferred from direct assayⁱ
- 9924025
cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17873522
cellular response to drug
Source: UniProtKB
Inferred from direct assayⁱ
- 17873522
- 19179467
cellular response to hypoxia
Source: CAFA
Inferred from direct assayⁱ
- 15459207
cellular response to UV
Source: UniProtKB
Inferred from expression patternⁱ
- 17873522
chromatin remodeling
Source: UniProtKB
Inferred from direct assayⁱ
- 21533051
chromosome organization
Source: UniProtKB
Inferred from direct assayⁱ
- 10962037
cytokine-mediated signaling pathway Source: Reactome
energy reserve metabolic process
Source: UniProtKB
Non-traceable author statementⁱ
- 9924025
ERK1 and ERK2 cascade
Source: CAFA
Inferred from direct assayⁱ
- 15459207
fibroblast apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 10962037
G1/S transition of mitotic cell cycle Source: Reactome
MAPK cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17873522
negative regulation of apoptotic process Source: UniProtKB
negative regulation of cell division
Source: UniProtKB
Inferred from direct assayⁱ
- 10962037
negative regulation of fibroblast proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 10962037
negative regulation of monocyte differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9924025
negative regulation of stress-activated MAPK cascade Source: UniProtKB
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 9924025
Notch signaling pathway Source: Reactome
oxygen transport
Source: UniProtKB
Non-traceable author statementⁱ
- 9924025
positive regulation of cell proliferation
Source: CAFA
Inferred from direct assayⁱ
- 19160485
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 19179467
positive regulation of DNA biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9924025
positive regulation of epithelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 18987311
positive regulation of fibroblast proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 18987311
- 9924025
positive regulation of gene expression
Source: CAFA
Inferred from direct assayⁱ
- 15459207
positive regulation of mesenchymal cell proliferation Source: UniProtKB
positive regulation of metanephric cap mesenchymal cell proliferation Source: UniProtKB
positive regulation of response to DNA damage stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 19179467
positive regulation of telomerase activity Source: BHF-UCL
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 10723141
protein deubiquitination Source: Reactome
protein-DNA complex disassembly
Source: CAFA
Inferred from direct assayⁱ
- 19160485
regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 21447833
regulation of telomere maintenance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17765874
regulation of transcription by RNA polymerase II Source: Reactome
response to drug
Source: UniProtKB
Inferred from expression patternⁱ
- 18291362
response to gamma radiation
Source: UniProtKB
Inferred from direct assayⁱ
- 19179467
response to growth factor
Source: UniProtKB
Traceable author statementⁱ
- 18987311

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000136997-MONOMER
Reactomeⁱ	R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689880 Ub-specific processing proteases R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P01106
SIGNORⁱ	P01106

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myc proto-oncogene protein Alternative name(s): Class E basic helix-loop-helix protein 39 Short name: bHLHe39 Proto-oncogene c-Myc Transcription factor p64
Gene namesⁱ	Name:MYC Synonyms:BHLHE39
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136997.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7553 MYC
MIMⁱ	190080 gene
neXtProtⁱ	NX_P01106

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.1 Publication

Burkitt lymphoma (BL)2 Publications

The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.

Disease descriptionA form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass.

Biotechnological useⁱ

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	58	T → A: Impairs interaction with FBXW7 and subsequent degradation by the proteasome. Normal inhibition of Ras-induced senescence. 4 Publications		1
Mutagenesisⁱ	62	S → A: Impairs interaction with FBXW7 and subsequent degradation by the proteasome. Impaired inhibition of Ras-induced senescence. Abolishes phosphorylation by DYRK2, and subsequent phosphorylation by GSK3B at Thr-58. 5 Publications		1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4609
MalaCards human disease database More...MalaCardsⁱ	MYC
MIMⁱ	113970 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000136997
Orphanetⁱ	543 Burkitt lymphoma 99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBⁱ	PA31353

Chemistry databases

ChEMBLⁱ	CHEMBL1250348
Drug and drug target database More...DrugBankⁱ	DB08813 Nadroparin

Polymorphism and mutation databases

BioMutaⁱ	MYC
DMDMⁱ	127619

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127293	1 – 439	Myc proto-oncogene proteinAdd BLAST		439

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	6	PhosphoserineCombined sources	1
Modified residueⁱ	8	Phosphothreonine; by RAF; in vitro1 Publication	1
Cross-linkⁱ	52	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	58	Phosphothreonine; by GSK3; alternateCombined sources3 Publications	1
GlycosylationⁱCAR_000033	58	O-linked (GlcNAc) threonine; alternate1 Publication	1
Modified residueⁱ	62	Phosphoserine; by DYRK2, GSK3 and CDK2Combined sources6 Publications	1
Modified residueⁱ	71	PhosphoserineCombined sources	1
Modified residueⁱ	143	N6-acetyllysine; by PCAF; alternate1 Publication	1
Cross-linkⁱ	143	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	148	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	148	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	157	N6-acetyllysine; by PCAF1 Publication	1
Modified residueⁱ	161	PhosphoserineCombined sources	1
Modified residueⁱ	275	N6-acetyllysine; by PCAF1 Publication	1
Modified residueⁱ	293	PhosphoserineCombined sources	1
Cross-linkⁱ	298	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	317	N6-acetyllysine; by PCAF1 Publication	1
Modified residueⁱ	323	N6-acetyllysine; by PCAF1 Publication	1
Modified residueⁱ	329	Phosphoserine; by PIM2; in vitroBy similarity	1
Modified residueⁱ	371	N6-acetyllysine; by PCAF1 Publication	1

Post-translational modificationⁱ

Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.By similarity6 Publications

Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus (PubMed:25775507,PubMed:17558397). Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).By similarity7 Publications

Keywords - PTMⁱ

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P01106
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01106
PaxDbⁱ	P01106
PeptideAtlas More...PeptideAtlasⁱ	P01106
PRIDEⁱ	P01106
ProteomicsDBⁱ	51318 51319 [P01106-2]

2D gel databases

SWISS-2DPAGEⁱ	P01106

SWISS-2DPAGEⁱ

P01106

PTM databases

GlyConnectⁱ	426
iPTMnetⁱ	P01106
PhosphoSitePlusⁱ	P01106
UniCarbKBⁱ	P01106

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136997 Expressed in 216 organ(s), highest expression level in thoracic mammary gland
CleanExⁱ	HS_MYC
ExpressionAtlasⁱ	P01106 baseline and differential
Genevisibleⁱ	P01106 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000084 CAB010307 HPA055893 HPA066556

HPAⁱ

CAB000084
CAB010307
HPA055893
HPA066556

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (PubMed:9680483). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7(PubMed:25775507, PubMed:17558397). Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (PubMed:25956029). Interacts with CIP2A; leading to the stabilization of MYC (PubMed:17632056).By similarity11 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P03070	2	EBI-447544,EBI-617698	From Simian virus 40.
AXIN1	O15169	10	EBI-447544,EBI-710484
BIN1	O00499-10	3	EBI-447544,EBI-7689134
BIN1	O00499-11	2	EBI-447544,EBI-7689211
BRD3	Q15059	3	EBI-447544,EBI-1383460
CCAR2	Q8N163	8	EBI-447544,EBI-355410
CDK4	P11802	2	EBI-447544,EBI-295644
CEP57	Q86XR8	3	EBI-447544,EBI-308614
CHD4	Q14839	2	EBI-447544,EBI-372916
CHUK	O15111	3	EBI-447544,EBI-81249
CIP2A	Q8TCG1	2	EBI-447544,EBI-1379376
E7	P03129	2	EBI-447544,EBI-866453	From Human papillomavirus type 16.
E7	P04020	2	EBI-447544,EBI-7005254	From Human papillomavirus type 11.
E7	P06788	5	EBI-447544,EBI-1776887	From Human papillomavirus type 18.
EBNA6	P03204	11	EBI-447544,EBI-9255985	From Epstein-Barr virus (strain B95-8).
EFTUD2	Q15029	5	EBI-447544,EBI-357897
EP400	Q96L91	4	EBI-447544,EBI-399163
EP400	Q96L91-2	2	EBI-447544,EBI-15698003
FBXW7	Q969H0	4	EBI-447544,EBI-359574
FBXW8	Q8N3Y1	3	EBI-447544,EBI-914770
FOXO3	O43524	3	EBI-447544,EBI-1644164
GSK3B	P49841-2	3	EBI-447544,EBI-15870655
HDAC2	Q92769	2	EBI-447544,EBI-301821
HDAC3	O15379	6	EBI-447544,EBI-607682
IKBKG	Q9Y6K9	3	EBI-447544,EBI-81279
MAX	P61244	33	EBI-447544,EBI-751711
Max	P52164	4	EBI-447544,EBI-1184963	From Rattus norvegicus.
MBD3	O95983	3	EBI-447544,EBI-1783068
MCM7	P33993	6	EBI-447544,EBI-355924
PIAS2	O75928	4	EBI-447544,EBI-348555
PIN1	Q13526	5	EBI-447544,EBI-714158
RPL11	P62913	3	EBI-447544,EBI-354380
SIN3B	O75182	7	EBI-447544,EBI-540462
Sin3b	Q62141	8	EBI-447544,EBI-591450	From Mus musculus.
SIRT1	Q96EB6	4	EBI-447544,EBI-1802965
SIRT6	Q8N6T7	3	EBI-447544,EBI-712415
SKP2	Q13309	2	EBI-447544,EBI-456291
SNIP1	Q8TAD8	9	EBI-447544,EBI-749336
SP1	P08047	4	EBI-447544,EBI-298336
TOP1	P11387	2	EBI-447544,EBI-876302
TP53BP1	Q12888	2	EBI-447544,EBI-396540
TRIP12	Q14669	7	EBI-447544,EBI-308443
TRRAP	Q9Y4A5	4	EBI-447544,EBI-399128
UBC	P0CG48	5	EBI-447544,EBI-3390054
UBTF	P17480	2	EBI-447544,EBI-396235
ZBTB17	Q13105	9	EBI-447544,EBI-372156

GO - Molecular functionⁱ

activating transcription factor binding
Source: CAFA
Inferred from physical interactionⁱ
- 19160485
protein dimerization activity Source: InterPro
repressing transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15674325
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15674325

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110694, 619 interactors
ComplexPortalⁱ	CPX-1123 FOXO3-MYC complex CPX-514 c-MYC-BIN1 complex CPX-91 Transcriptional activator Myc-Max complex
CORUMⁱ	P01106
Database of interacting proteins More...DIPⁱ	DIP-28143N
IntActⁱ	P01106, 717 interactors
Molecular INTeraction database More...MINTⁱ	P01106
STRINGⁱ	9606.ENSP00000367207

Chemistry databases

BindingDBⁱ

P01106

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	353 – 378	Combined sources	26
Helixⁱ	382 – 384	Combined sources	3
Helixⁱ	392 – 434	Combined sources	43

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00260
ProteinModelPortalⁱ	P01106
SMRⁱ	P01106
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P01106

EvolutionaryTraceⁱ

P01106

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	354 – 406	bHLHPROSITE-ProRule annotationAdd BLAST		53

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	413 – 434	Leucine-zipperAdd BLAST		22

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	33 – 37	Poly-Gln		5
Compositional biasⁱ	88 – 91	Poly-Gly		4

Phylogenomic databases

eggNOGⁱ	ENOG410IFSM Eukaryota ENOG41124Q3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046414
HOGENOMⁱ	HOG000043075
HOVERGENⁱ	HBG000472
InParanoidⁱ	P01106
KEGG Orthology (KO) More...KOⁱ	K04377
PhylomeDBⁱ	P01106
TreeFamⁱ	TF106001

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003327 Myc-LZ IPR002418 Tscrpt_reg_Myc IPR012682 Tscrpt_reg_Myc_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF02344 Myc-LZ, 1 hit PF01056 Myc_N, 1 hit
PIRSFⁱ	PIRSF001705 Myc_protein, 1 hit
PRINTSⁱ	PR00044 LEUZIPPRMYC
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P01106-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW 
        60         70         80         90        100
KKFELLPTPP LSPSRRSGLC SPSYVAVTPF SLRGDNDGGG GSFSTADQLE 
       110        120        130        140        150
MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA 
       160        170        180        190        200
SYQAARKDSG SPNPARGHSV CSTSSLYLQD LSAAASECID PSVVFPYPLN 
       210        220        230        240        250
DSSSPKSCAS QDSSAFSPSS DSLLSSTESS PQGSPEPLVL HEETPPTTSS 
       260        270        280        290        300
DSEEEQEDEE EIDVVSVEKR QAPGKRSESG SPSAGGHSKP PHSPLVLKRC 
       310        320        330        340        350
HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT 
       360        370        380        390        400
EENVKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT 
       410        420        430 
AYILSVQAEE QKLISEEDLL RKRREQLKHK LEQLRNSCA

Length:439

Mass (Da):48,804

Last modified:August 13, 1987 - v1

Checksum:ⁱED5C028029A4C5D1

GO

Isoform 2 (identifier: P01106-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDFFRVVENQQPPATM

« Hide

        10         20         30         40         50
MDFFRVVENQ QPPATMPLNV SFTNRNYDLD YDSVQPYFYC DEEENFYQQQ 
        60         70         80         90        100
QQSELQPPAP SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVTPFSLRGD 
       110        120        130        140        150
NDGGGGSFST ADQLEMVTEL LGGDMVNQSF ICDPDDETFI KNIIIQDCMW 
       160        170        180        190        200
SGFSAAAKLV SEKLASYQAA RKDSGSPNPA RGHSVCSTSS LYLQDLSAAA 
       210        220        230        240        250
SECIDPSVVF PYPLNDSSSP KSCASQDSSA FSPSSDSLLS STESSPQGSP 
       260        270        280        290        300
EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQAPGK RSESGSPSAG 
       310        320        330        340        350
GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRV KLDSVRVLRQ 
       360        370        380        390        400
ISNNRKCTSP RSSDTEENVK RRTHNVLERQ RRNELKRSFF ALRDQIPELE 
       410        420        430        440        450
NNEKAPKVVI LKKATAYILS VQAEEQKLIS EEDLLRKRRE QLKHKLEQLR 

NSCA

Note: Initiates from CTG codon.Curated

Show »

Length:454

Mass (Da):50,565

Checksum:ⁱ8B4107BB740689E5

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
Q14899	Q14899_HUMAN	Myc proto-oncogene protein Myc proto-oncogene protein (Myc-related translation/localization regulatory factor) (ORF 114)	MYC MRTL	114	Annotation score:
H0YBT0	H0YBT0_HUMAN	Myc proto-oncogene protein Myc proto-oncogene protein	MYC	453	Annotation score:
A0A087WUS5	A0A087WUS5_HUMAN	Myc proto-oncogene protein Myc proto-oncogene protein	MYC	454	Annotation score:
A0A087WVR4	A0A087WVR4_HUMAN	Myc proto-oncogene protein Myc proto-oncogene protein	MYC	454	Annotation score:
A0A0B4J1R1	A0A0B4J1R1_HUMAN	Myc proto-oncogene protein Myc proto-oncogene protein (V-myc myelocytomatosis viral oncogene homolog (Avian), isoform CRA_b)	MYC hCG_15917	257	Annotation score:
H0YBG3	H0YBG3_HUMAN	Myc proto-oncogene protein Myc proto-oncogene protein	MYC	184	Annotation score:
E5RGD7	E5RGD7_HUMAN	Myc proto-oncogene protein Myc proto-oncogene protein	MYC	59	Annotation score:
Q16591	Q16591_HUMAN	Myc protein Myc protein (Myc proto-oncogene protein) (ORF 118)	MYC	188	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6 – 7	SF → TI no nucleotide entry (PubMed:6419122).Curated	2
Sequence conflictⁱ	10	R → K no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	56	L → LL no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	62	S → P in CAA25288 (PubMed:6547209).Curated	1
Sequence conflictⁱ	88	G → D no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	92	S → N no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	114	S → N no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	120	D → G no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	171	C → S no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	203	S → R no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	230	S → A no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	240	L → F no nucleotide entry (PubMed:6419122).Curated	1
Sequence conflictⁱ	245	P → S no nucleotide entry (PubMed:6419122).Curated	1
Isoform 2 (identifier: P01106-2)
Sequence conflictⁱ	2	D → N in BAA01374 (PubMed:6547209).Curated	1
Sequence conflictⁱ	6	V → E in BAA01374 (PubMed:6547209).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_016327	11	N → S1 PublicationCorresponds to variant dbSNP:rs4645959Ensembl.	1
Natural variantⁱVAR_063384	39	E → D in a Burkitt lymphoma symple. 2 PublicationsCorresponds to variant dbSNP:rs121918684Ensembl.	1
Natural variantⁱVAR_063385	57	P → S in a Burkitt lymphoma sample. 1 PublicationCorresponds to variant dbSNP:rs28933407Ensembl.	1
Natural variantⁱVAR_063386	59	P → A in a Burkitt lymphoma sample. 1 PublicationCorresponds to variant dbSNP:rs121918685Ensembl.	1
Natural variantⁱVAR_063387	86	N → T in a Burkitt lymphoma sample. 1 PublicationCorresponds to variant dbSNP:rs121918683Ensembl.	1
Natural variantⁱVAR_016328	160	G → C1 PublicationCorresponds to variant dbSNP:rs4645960Ensembl.	1
Natural variantⁱVAR_016329	170	V → I1 PublicationCorresponds to variant dbSNP:rs4645961Ensembl.	1
Natural variantⁱVAR_016330	322	A → V1 PublicationCorresponds to variant dbSNP:rs4645968Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037813	1	M → MDFFRVVENQQPPATM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L00058, L00057 Genomic DNA Translation: AAA59882.1 K00535, K00534 Genomic DNA Translation: AAA59880.1 K00535, K00534 Genomic DNA Translation: ABW69847.1 X00196, X00198 Genomic DNA Translation: CAA25015.2 X00364 Genomic DNA Translation: CAA25106.1 V00568 mRNA Translation: CAA23831.1 K01906, K01905 Genomic DNA Translation: AAA59881.1 K02276 mRNA Translation: AAA36340.1 X00676 Genomic DNA Translation: CAA25288.1 D10493 Genomic DNA Translation: BAA01374.2 D10493 Genomic DNA Translation: BAA01375.1 BT019768 mRNA Translation: AAV38573.1 AY214166 Genomic DNA Translation: AAO21131.1 AK312883 mRNA Translation: BAG35731.1 AC103819 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92098.1 BC000141 mRNA Translation: AAH00141.2 BC000917 mRNA Translation: AAH00917.2 BC058901 mRNA Translation: AAH58901.2 M13929 mRNA Translation: AAA88092.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6359.2 [P01106-2]
PIRⁱ	A01349 TVHUM A01350 TVHUT
NCBI Reference Sequences More...RefSeqⁱ	NP_002458.2, NM_002467.4 [P01106-2]
UniGeneⁱ	Hs.202453

Genome annotation databases

Ensemblⁱ	ENST00000377970; ENSP00000367207; ENSG00000136997 [P01106-1] ENST00000613283; ENSP00000479618; ENSG00000136997 [P01106-2]
GeneIDⁱ	4609
KEGGⁱ	hsa:4609
UCSC genome browser More...UCSCⁱ	uc064qdj.1 human [P01106-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01106	Myc proto-oncogene protein		HUMAN		454	UniRef100_P01106
V-myc myelocytomatosis viral oncogene homolog (Avian), isoform CRA_a		HUMAN		439
V-myc myelocytomatosis viral oncogene homolog (Fragment)		HUMAN		252
C-myc protein (Fragment)		HUMAN		60
P01106-2	Myc proto-oncogene protein		HUMAN		454	UniRef100_A0A087WVR4
V-myc myelocytomatosis viral oncogene homolog (Fragment)		HUMAN		267

Protein	Similar proteins		Species	Score	Length	Source
P01106	Myc proto-oncogene protein		MOUSE		439	UniRef90_P01106
Myc proto-oncogene protein		RAT		439
Myc proto-oncogene protein		PANPA		439
Myc proto-oncogene protein		PANTR		439
Myc proto-oncogene protein		PIG		439
+81

Protein	Similar proteins		Species	Score	Length	Source
P01106	Myc proto-oncogene protein		PANPA		439	UniRef50_P01106
Myc proto-oncogene protein		MOUSE		439
Myc proto-oncogene protein		RAT		439
Myc proto-oncogene protein		PANTR		439
Myc proto-oncogene protein		PIG		439
+207

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Wikipedia

Myc entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L00058, L00057 Genomic DNA Translation: AAA59882.1 K00535, K00534 Genomic DNA Translation: AAA59880.1 K00535, K00534 Genomic DNA Translation: ABW69847.1 X00196, X00198 Genomic DNA Translation: CAA25015.2 X00364 Genomic DNA Translation: CAA25106.1 V00568 mRNA Translation: CAA23831.1 K01906, K01905 Genomic DNA Translation: AAA59881.1 K02276 mRNA Translation: AAA36340.1 X00676 Genomic DNA Translation: CAA25288.1 D10493 Genomic DNA Translation: BAA01374.2 D10493 Genomic DNA Translation: BAA01375.1 BT019768 mRNA Translation: AAV38573.1 AY214166 Genomic DNA Translation: AAO21131.1 AK312883 mRNA Translation: BAG35731.1 AC103819 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW92098.1 BC000141 mRNA Translation: AAH00141.2 BC000917 mRNA Translation: AAH00917.2 BC058901 mRNA Translation: AAH58901.2 M13929 mRNA Translation: AAA88092.1
CCDSⁱ	CCDS6359.2 [P01106-2]
PIRⁱ	A01349 TVHUM A01350 TVHUT
RefSeqⁱ	NP_002458.2, NM_002467.4 [P01106-2]
UniGeneⁱ	Hs.202453

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A93	NMR	-	A	406-434	[»]
	1EE4	X-ray	2.10	C/D/E/F	320-328	[»]
	1MV0	NMR	-	A	55-68	[»]
	1NKP	X-ray	1.80	A/D	353-434	[»]
	2A93	NMR	-	A	406-434	[»]
	2OR9	X-ray	2.70	P	410-419	[»]
	4Y7R	X-ray	1.90	B	260-267	[»]
	5I4Z	X-ray	1.95	A/B	350-439	[»]
	5I50	X-ray	2.70	A/B	350-439	[»]
DisProtⁱ	DP00260
ProteinModelPortalⁱ	P01106
SMRⁱ	P01106
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110694, 619 interactors
ComplexPortalⁱ	CPX-1123 FOXO3-MYC complex CPX-514 c-MYC-BIN1 complex CPX-91 Transcriptional activator Myc-Max complex
CORUMⁱ	P01106
DIPⁱ	DIP-28143N
IntActⁱ	P01106, 717 interactors
MINTⁱ	P01106
STRINGⁱ	9606.ENSP00000367207

Chemistry databases

BindingDBⁱ	P01106
ChEMBLⁱ	CHEMBL1250348
DrugBankⁱ	DB08813 Nadroparin

PTM databases

GlyConnectⁱ	426
iPTMnetⁱ	P01106
PhosphoSitePlusⁱ	P01106
UniCarbKBⁱ	P01106

Polymorphism and mutation databases

BioMutaⁱ	MYC
DMDMⁱ	127619

2D gel databases

SWISS-2DPAGEⁱ	P01106

SWISS-2DPAGEⁱ

P01106

Proteomic databases

EPDⁱ	P01106
MaxQBⁱ	P01106
PaxDbⁱ	P01106
PeptideAtlasⁱ	P01106
PRIDEⁱ	P01106
ProteomicsDBⁱ	51318 51319 [P01106-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4609
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377970; ENSP00000367207; ENSG00000136997 [P01106-1] ENST00000613283; ENSP00000479618; ENSG00000136997 [P01106-2]
GeneIDⁱ	4609
KEGGⁱ	hsa:4609
UCSCⁱ	uc064qdj.1 human [P01106-1]

Organism-specific databases

CTDⁱ	4609
DisGeNETⁱ	4609
EuPathDBⁱ	HostDB:ENSG00000136997.15
GeneCardsⁱ	MYC
H-InvDBⁱ	HIX0007784
HGNCⁱ	HGNC:7553 MYC
HPAⁱ	CAB000084 CAB010307 HPA055893 HPA066556
MalaCardsⁱ	MYC
MIMⁱ	113970 phenotype 190080 gene
neXtProtⁱ	NX_P01106
OpenTargetsⁱ	ENSG00000136997
Orphanetⁱ	543 Burkitt lymphoma 99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBⁱ	PA31353
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFSM Eukaryota ENOG41124Q3 LUCA
GeneTreeⁱ	ENSGT00510000046414
HOGENOMⁱ	HOG000043075
HOVERGENⁱ	HBG000472
InParanoidⁱ	P01106
KOⁱ	K04377
PhylomeDBⁱ	P01106
TreeFamⁱ	TF106001

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000136997-MONOMER
Reactomeⁱ	R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689880 Ub-specific processing proteases R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P01106
SIGNORⁱ	P01106

Miscellaneous databases

ChiTaRSⁱ	MYC human
EvolutionaryTraceⁱ	P01106
GeneWikiⁱ	Myc
GenomeRNAiⁱ	4609
Protein Ontology More...PROⁱ	PR:P01106
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136997 Expressed in 216 organ(s), highest expression level in thoracic mammary gland
CleanExⁱ	HS_MYC
ExpressionAtlasⁱ	P01106 baseline and differential
Genevisibleⁱ	P01106 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003327 Myc-LZ IPR002418 Tscrpt_reg_Myc IPR012682 Tscrpt_reg_Myc_N
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF02344 Myc-LZ, 1 hit PF01056 Myc_N, 1 hit
PIRSFⁱ	PIRSF001705 Myc_protein, 1 hit
PRINTSⁱ	PR00044 LEUZIPPRMYC
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYC_HUMAN
Accessionⁱ	P01106Primary (citable) accession number: P01106 Secondary accession number(s): A8WFE7, P01107, Q14026
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	August 13, 1987
	Last modified:	September 12, 2018
	This is version 236 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - P01106 (MYC_HUMAN)

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Myc proto-oncogene protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Biotechnological useⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ