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Protein

Kininogen-1

Gene

KNG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  • heparin binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor, Vasoactive, Vasodilator
Biological processBlood coagulation, Hemostasis, Inflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I25.016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kininogen-1
Alternative name(s):
Alpha-2-thiol proteinase inhibitor
Fitzgerald factor
High molecular weight kininogen
Short name:
HMWK
Williams-Fitzgerald-Flaujeac factor
Cleaved into the following 6 chains:
Alternative name(s):
Ile-Ser-Bradykinin
Alternative name(s):
Kallidin I
Alternative name(s):
Kallidin II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KNG1
Synonyms:BDK, KNG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000113889.11

Human Gene Nomenclature Database

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HGNCi
HGNC:6383 KNG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612358 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01042

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

High molecular weight kininogen deficiency (HMWK deficiency)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.
See also OMIM:228960

Organism-specific databases

DisGeNET

More...
DisGeNETi
3827

MalaCards human disease database

More...
MalaCardsi
KNG1
MIMi228960 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113889

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
483 Congenital high-molecular-weight kininogen deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA225

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3638337

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KNG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124056474

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 182 PublicationsAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000668519 – 644Kininogen-1Add BLAST626
ChainiPRO_000000668619 – 380Kininogen-1 heavy chainAdd BLAST362
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000372485376 – 389T-kininAdd BLAST14
PeptideiPRO_0000006687380 – 389Lysyl-bradykinin10
PeptideiPRO_0000006688381 – 389Bradykinin9
ChainiPRO_0000006689390 – 644Kininogen-1 light chainAdd BLAST255
PeptideiPRO_0000006690431 – 434Low molecular weight growth-promoting factor4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19Pyrrolidone carboxylic acid; in mature formBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 614Interchain (between heavy and light chains)PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) (complex) asparagine2 Publications1
Disulfide bondi83 ↔ 94PROSITE-ProRule annotation1 Publication
Disulfide bondi107 ↔ 126PROSITE-ProRule annotation1 Publication
Disulfide bondi142 ↔ 145PROSITE-ProRule annotation1 Publication
Glycosylationi169N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi205N-linked (GlcNAc...) (complex) asparagine4 Publications1
Disulfide bondi206 ↔ 218PROSITE-ProRule annotation1 Publication
Disulfide bondi229 ↔ 248PROSITE-ProRule annotation1 Publication
Disulfide bondi264 ↔ 267PROSITE-ProRule annotation1 Publication
Glycosylationi294N-linked (GlcNAc...) (complex) asparagine6 Publications1
Disulfide bondi328 ↔ 340PROSITE-ProRule annotation1 Publication
Modified residuei332Phosphoserine; by FAM20CCombined sources1 Publication1
Disulfide bondi351 ↔ 370PROSITE-ProRule annotation1 Publication
Modified residuei3834-hydroxyproline; partial2 Publications1
Glycosylationi401O-linked (GalNAc...) threonine1
Glycosylationi533O-linked (GalNAc...) threonine1 Publication1
Glycosylationi542O-linked (GalNAc...) threonine1
Glycosylationi546O-linked (GalNAc...) threonine1 Publication1
Glycosylationi557O-linked (GalNAc...) threonine1
Glycosylationi571O-linked (GalNAc...) threonine1
Glycosylationi577O-linked (GalNAc...) serine1
Glycosylationi628O-linked (GalNAc...) threonine1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Bradykinin is released from kininogen by plasma kallikrein.
Hydroxylation of Pro-383 occurs prior to the release of bradykinin.2 Publications
Phosphorylated by FAM20C in the extracellular medium.1 Publication
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei48Not glycosylated1 Publication1
Sitei379 – 380Cleavage; by kallikrein2
Sitei389 – 390Cleavage; by kallikrein2

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P01042

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01042

PeptideAtlas

More...
PeptideAtlasi
P01042

PRoteomics IDEntifications database

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PRIDEi
P01042

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51315
51316 [P01042-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P01042

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P01042

GlyConnect protein glycosylation platform

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GlyConnecti
810

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01042

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01042

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01042

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113889 Expressed in 72 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_KNG1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01042 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009809
HPA001616
HPA001645

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110026, 33 interactors

Protein interaction database and analysis system

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IntActi
P01042, 13 interactors

Molecular INTeraction database

More...
MINTi
P01042

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265023

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P01042

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1644
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P01042

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01042

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01042

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 132Cystatin kininogen-type 1PROSITE-ProRule annotationAdd BLAST105
Domaini151 – 254Cystatin kininogen-type 2PROSITE-ProRule annotationAdd BLAST104
Domaini273 – 376Cystatin kininogen-type 3PROSITE-ProRule annotationAdd BLAST104
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati420 – 449Add BLAST30
Repeati450 – 479Add BLAST30
Repeati480 – 510Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni120 – 153O-glycosylated at one site onlyAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi420 – 510His-richAdd BLAST91

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKIQ Eukaryota
ENOG4111ZQ8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113239

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006224

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01042

KEGG Orthology (KO)

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KOi
K03898

Identification of Orthologs from Complete Genome Data

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OMAi
DWIPDIQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0SH2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01042

TreeFam database of animal gene trees

More...
TreeFami
TF351852

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00042 CY, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000010 Cystatin_dom
IPR002395 Kininogen
IPR027358 Kininogen-type_cystatin_dom
IPR018073 Prot_inh_cystat_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00031 Cystatin, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00334 KININOGEN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00043 CY, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00287 CYSTATIN, 2 hits
PS51647 CYSTATIN_KININOGEN, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform HMW (identifier: P01042-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS
60 70 80 90 100
NNQFVLYRIT EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA
110 120 130 140 150
KAATGECTAT VGKRSSTKFS VATQTCQITP AEGPVVTAQY DCLGCVHPIS
160 170 180 190 200
TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN EVKRAQRQVV AGLNFRITYS
210 220 230 240 250
IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR IASFSQNCDI
260 270 280 290 300
YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK
310 320 330 340 350
IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD
360 370 380 390 400
CNAEVYVVPW EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET
410 420 430 440 450
TVSPPHTSMA PAQDEERDSG KEQGHTRRHD WGHEKQRKHN LGHGHKHERD
460 470 480 490 500
QGHGHQRGHG LGHGHEQQHG LGHGHKFKLD DDLEHQGGHV LDHGHKHKHG
510 520 530 540 550
HGHGKHKNKG KKNGKHNGWK TEHLASSSED STTPSAQTQE KTEGPTPIPS
560 570 580 590 600
LAKPGVTVTF SDFQDSDLIA TMMPPISPAP IQSDDDWIPD IQIDPNGLSF
610 620 630 640
NPISDFPDTT SPKCPGRPWK SVSEINPTTQ MKESYYFDLT DGLS
Length:644
Mass (Da):71,957
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3132B4DF2954C24E
GO
Isoform LMW (identifier: P01042-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-427: VSPPHTSMAPAQDEERDSGKEQGHTR → SHLRSCEYKGRPPKAGAEPASEREVS
     428-644: Missing.

Show »
Length:427
Mass (Da):47,883
Checksum:iC8B398F00BE38BE9
GO
Isoform 3 (identifier: P01042-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-224: Missing.
     402-643: VSPPHTSMAP...SYYFDLTDGL → SHLRSCEYKGRPPKAGAEPASEREV

Note: Gene prediction based on EST data.
Show »
Length:391
Mass (Da):43,822
Checksum:iE2126218B3462290
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33L → F in BAF83528 (PubMed:14702039).Curated1
Sequence conflicti311V → A in BAF83528 (PubMed:14702039).Curated1
Sequence conflicti593I → T in AAO61092 (Ref. 5) Curated1
Sequence conflicti593I → T AA sequence (PubMed:4054110).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The T-kinin peptide is missing residues 378 to 380, probably as a result of a naturally occurring variant. The complete sequence of the T-kinin peptide is therefore ISRPPGFSPFR. This peptide is associated with malignant tumors but not with benign ones.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019277163G → S1 PublicationCorresponds to variant dbSNP:rs5030015Ensembl.1
Natural variantiVAR_019278178M → T3 PublicationsCorresponds to variant dbSNP:rs1656922Ensembl.1
Natural variantiVAR_028937197I → M1 PublicationCorresponds to variant dbSNP:rs2304456Ensembl.1
Natural variantiVAR_019279212L → P1 PublicationCorresponds to variant dbSNP:rs5030024Ensembl.1
Natural variantiVAR_055233378 – 380Missing in T-kinin peptide. 2 Publications3
Natural variantiVAR_048853430D → E. Corresponds to variant dbSNP:rs5030084Ensembl.1
Natural variantiVAR_048854581I → T. Corresponds to variant dbSNP:rs710446Ensembl.1
Natural variantiVAR_048855642G → A. Corresponds to variant dbSNP:rs5030087Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047307189 – 224Missing in isoform 3. CuratedAdd BLAST36
Alternative sequenceiVSP_047308402 – 643VSPPH…LTDGL → SHLRSCEYKGRPPKAGAEPA SEREV in isoform 3. CuratedAdd BLAST242
Alternative sequenceiVSP_001261402 – 427VSPPH…QGHTR → SHLRSCEYKGRPPKAGAEPA SEREVS in isoform LMW. 4 PublicationsAdd BLAST26
Alternative sequenceiVSP_001262428 – 644Missing in isoform LMW. 4 PublicationsAdd BLAST217

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
K02566 mRNA Translation: AAA35497.1
M11437
, M11438, M11521, M11522, M11523, M11524, M11525, M11526, M11527, M11528 Genomic DNA Translation: AAB59550.1
M11437
, M11438, M11521, M11522, M11523, M11524, M11525, M11526, M11527, M11528 Genomic DNA Translation: AAB59551.1
AK315230 mRNA Translation: BAG37659.1
AK290839 mRNA Translation: BAF83528.1
AK223589 mRNA Translation: BAD97309.1
AY248697 Genomic DNA Translation: AAO61092.1
AC109780 Genomic DNA No translation available.
AC112907 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78179.1
BC060039 mRNA Translation: AAH60039.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3281.1 [P01042-2]
CCDS43183.1 [P01042-1]
CCDS54695.1 [P01042-3]

Protein sequence database of the Protein Information Resource

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PIRi
A01279 KGHUH1
A01280 KGHUL1
S13279

NCBI Reference Sequences

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RefSeqi
NP_000884.1, NM_000893.3 [P01042-2]
NP_001095886.1, NM_001102416.2 [P01042-1]
NP_001159923.1, NM_001166451.1 [P01042-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.77741

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265023; ENSP00000265023; ENSG00000113889 [P01042-1]
ENST00000287611; ENSP00000287611; ENSG00000113889 [P01042-2]
ENST00000447445; ENSP00000396025; ENSG00000113889 [P01042-3]
ENST00000644859; ENSP00000493985; ENSG00000113889 [P01042-1]
ENST00000645909; ENSP00000496167; ENSG00000113889 [P01042-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3827

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3827

UCSC genome browser

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UCSCi
uc003fqr.4 human [P01042-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

High molecular weight kininogen entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02566 mRNA Translation: AAA35497.1
M11437
, M11438, M11521, M11522, M11523, M11524, M11525, M11526, M11527, M11528 Genomic DNA Translation: AAB59550.1
M11437
, M11438, M11521, M11522, M11523, M11524, M11525, M11526, M11527, M11528 Genomic DNA Translation: AAB59551.1
AK315230 mRNA Translation: BAG37659.1
AK290839 mRNA Translation: BAF83528.1
AK223589 mRNA Translation: BAD97309.1
AY248697 Genomic DNA Translation: AAO61092.1
AC109780 Genomic DNA No translation available.
AC112907 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78179.1
BC060039 mRNA Translation: AAH60039.1
CCDSiCCDS3281.1 [P01042-2]
CCDS43183.1 [P01042-1]
CCDS54695.1 [P01042-3]
PIRiA01279 KGHUH1
A01280 KGHUL1
S13279
RefSeqiNP_000884.1, NM_000893.3 [P01042-2]
NP_001095886.1, NM_001102416.2 [P01042-1]
NP_001159923.1, NM_001166451.1 [P01042-3]
UniGeneiHs.77741

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NY2X-ray2.304381-385[»]
2WOKX-ray1.70B381-389[»]
4ASQX-ray1.99P381-389[»]
4ASRX-ray1.90P381-389[»]
4ECBX-ray2.20A/B498-507[»]
4ECCX-ray2.20A498-510[»]
5I25X-ray2.85B601-608[»]
6F27NMR-A380-388[»]
6F3VNMR-A381-389[»]
6F3WNMR-A381-389[»]
6F3XNMR-A380-388[»]
6F3YNMR-A380-388[»]
ProteinModelPortaliP01042
SMRiP01042
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110026, 33 interactors
IntActiP01042, 13 interactors
MINTiP01042
STRINGi9606.ENSP00000265023

Chemistry databases

BindingDBiP01042
ChEMBLiCHEMBL3638337

Protein family/group databases

MEROPSiI25.016

PTM databases

CarbonylDBiP01042
GlyConnecti810
iPTMnetiP01042
PhosphoSitePlusiP01042

Polymorphism and mutation databases

BioMutaiKNG1
DMDMi124056474

2D gel databases

SWISS-2DPAGEiP01042

Proteomic databases

EPDiP01042
PaxDbiP01042
PeptideAtlasiP01042
PRIDEiP01042
ProteomicsDBi51315
51316 [P01042-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265023; ENSP00000265023; ENSG00000113889 [P01042-1]
ENST00000287611; ENSP00000287611; ENSG00000113889 [P01042-2]
ENST00000447445; ENSP00000396025; ENSG00000113889 [P01042-3]
ENST00000644859; ENSP00000493985; ENSG00000113889 [P01042-1]
ENST00000645909; ENSP00000496167; ENSG00000113889 [P01042-2]
GeneIDi3827
KEGGihsa:3827
UCSCiuc003fqr.4 human [P01042-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3827
DisGeNETi3827
EuPathDBiHostDB:ENSG00000113889.11

GeneCards: human genes, protein and diseases

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GeneCardsi
KNG1
HGNCiHGNC:6383 KNG1
HPAiCAB009809
HPA001616
HPA001645
MalaCardsiKNG1
MIMi228960 phenotype
612358 gene
neXtProtiNX_P01042
OpenTargetsiENSG00000113889
Orphaneti483 Congenital high-molecular-weight kininogen deficiency
PharmGKBiPA225

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKIQ Eukaryota
ENOG4111ZQ8 LUCA
GeneTreeiENSGT00940000154051
HOGENOMiHOG000113239
HOVERGENiHBG006224
InParanoidiP01042
KOiK03898
OMAiDWIPDIQ
OrthoDBiEOG091G0SH2
PhylomeDBiP01042
TreeFamiTF351852

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KNG1 human
EvolutionaryTraceiP01042

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Kininogen_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3827
PMAP-CutDBiP01042

Protein Ontology

More...
PROi
PR:P01042

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113889 Expressed in 72 organ(s), highest expression level in liver
CleanExiHS_KNG1
GenevisibleiP01042 HS

Family and domain databases

CDDicd00042 CY, 3 hits
InterProiView protein in InterPro
IPR000010 Cystatin_dom
IPR002395 Kininogen
IPR027358 Kininogen-type_cystatin_dom
IPR018073 Prot_inh_cystat_CS
PfamiView protein in Pfam
PF00031 Cystatin, 3 hits
PRINTSiPR00334 KININOGEN
SMARTiView protein in SMART
SM00043 CY, 3 hits
PROSITEiView protein in PROSITE
PS00287 CYSTATIN, 2 hits
PS51647 CYSTATIN_KININOGEN, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKNG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01042
Secondary accession number(s): A8K474
, B2RCR2, C9JEX1, P01043, Q53EQ0, Q6PAU9, Q7M4P1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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