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Protein

Cystatin-SN

Gene

CST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei32Reactive site1

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.010

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-SN
Alternative name(s):
Cystain-SA-I
Cystatin-1
Salivary cystatin-SA-1
Gene namesi
Name:CST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000170373.8
HGNCiHGNC:2473 CST1
MIMi123855 gene
neXtProtiNX_P01037

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1469
OpenTargetsiENSG00000170373
PharmGKBiPA26972

Polymorphism and mutation databases

BioMutaiCST1
DMDMi311033460

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 203 PublicationsAdd BLAST20
ChainiPRO_000000664921 – 141Cystatin-SNAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 1041 Publication
Disulfide bondi118 ↔ 1381 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01037
MaxQBiP01037
PaxDbiP01037
PeptideAtlasiP01037
PRIDEiP01037
ProteomicsDBi51313
TopDownProteomicsiP01037

Expressioni

Tissue specificityi

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.1 Publication

Gene expression databases

BgeeiENSG00000170373 Expressed in 72 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_CST1
GenevisibleiP01037 HS

Organism-specific databases

HPAiCAB026769
HPA043706
HPA044763

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-1056240,EBI-347996

Protein-protein interaction databases

BioGridi107851, 38 interactors
IntActiP01037, 4 interactors
STRINGi9606.ENSP00000305731

Structurei

3D structure databases

ProteinModelPortaliP01037
SMRiP01037
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 80Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZZH Eukaryota
ENOG4112CFJ LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000231754
HOVERGENiHBG009556
InParanoidiP01037
KOiK13897
OMAiEVPWENR
OrthoDBiEOG091G0TP1
PhylomeDBiP01037

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
IPR018073 Prot_inh_cystat_CS
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
PROSITEiView protein in PROSITE
PS00287 CYSTATIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01037-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQYLSTLLL LLATLAVALA WSPKEEDRII PGGIYNADLN DEWVQRALHF
60 70 80 90 100
AISEYNKATK DDYYRRPLRV LRARQQTVGG VNYFFDVEVG RTICTKSQPN
110 120 130 140
LDTCAFHEQP ELQKKQLCSF EIYEVPWENR RSLVKSRCQE S
Length:141
Mass (Da):16,388
Last modified:November 2, 2010 - v3
Checksum:i9F9934704D6C077D
GO

Mass spectrometryi

Molecular mass is 14303.1553±0.0675 Da from positions 21 - 141. Determined by ESI. 1 Publication
Molecular mass is 14319.171±0.0523 Da from positions 21 - 141. Determined by ESI. Variant Leu-31.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0289324Y → H2 PublicationsCorresponds to variant dbSNP:rs6076122Ensembl.1
Natural variantiVAR_02893331P → L. Corresponds to variant dbSNP:rs2070856Ensembl.1
Natural variantiVAR_028934129N → D. Corresponds to variant dbSNP:rs3188319Ensembl.1
Natural variantiVAR_028935131R → M. Corresponds to variant dbSNP:rs3188320Ensembl.1
Natural variantiVAR_028936135K → N. Corresponds to variant dbSNP:rs3188322Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19169 Genomic DNA Translation: AAA36115.1
J03870 mRNA Translation: AAA60299.1
AL591074 Genomic DNA No translation available.
BC021225 mRNA Translation: AAH21225.1
CCDSiCCDS13160.1
PIRiA28110 UDHUP2
RefSeqiNP_001889.2, NM_001898.2
UniGeneiHs.123114

Genome annotation databases

EnsembliENST00000304749; ENSP00000305731; ENSG00000170373
ENST00000398402; ENSP00000381439; ENSG00000170373
GeneIDi1469
KEGGihsa:1469
UCSCiuc002wtp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19169 Genomic DNA Translation: AAA36115.1
J03870 mRNA Translation: AAA60299.1
AL591074 Genomic DNA No translation available.
BC021225 mRNA Translation: AAH21225.1
CCDSiCCDS13160.1
PIRiA28110 UDHUP2
RefSeqiNP_001889.2, NM_001898.2
UniGeneiHs.123114

3D structure databases

ProteinModelPortaliP01037
SMRiP01037
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107851, 38 interactors
IntActiP01037, 4 interactors
STRINGi9606.ENSP00000305731

Protein family/group databases

MEROPSiI25.010

Polymorphism and mutation databases

BioMutaiCST1
DMDMi311033460

Proteomic databases

EPDiP01037
MaxQBiP01037
PaxDbiP01037
PeptideAtlasiP01037
PRIDEiP01037
ProteomicsDBi51313
TopDownProteomicsiP01037

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304749; ENSP00000305731; ENSG00000170373
ENST00000398402; ENSP00000381439; ENSG00000170373
GeneIDi1469
KEGGihsa:1469
UCSCiuc002wtp.3 human

Organism-specific databases

CTDi1469
DisGeNETi1469
EuPathDBiHostDB:ENSG00000170373.8
GeneCardsiCST1
HGNCiHGNC:2473 CST1
HPAiCAB026769
HPA043706
HPA044763
MIMi123855 gene
neXtProtiNX_P01037
OpenTargetsiENSG00000170373
PharmGKBiPA26972
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZZH Eukaryota
ENOG4112CFJ LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000231754
HOVERGENiHBG009556
InParanoidiP01037
KOiK13897
OMAiEVPWENR
OrthoDBiEOG091G0TP1
PhylomeDBiP01037

Miscellaneous databases

ChiTaRSiCST1 human
GeneWikiiCST1
GenomeRNAii1469
PROiPR:P01037
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170373 Expressed in 72 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_CST1
GenevisibleiP01037 HS

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
IPR018073 Prot_inh_cystat_CS
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
PROSITEiView protein in PROSITE
PS00287 CYSTATIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYTN_HUMAN
AccessioniPrimary (citable) accession number: P01037
Secondary accession number(s): Q96LE6, Q9UCQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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