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UniProtKB - P01033 (TIMP1_HUMAN)

Entry version 221 (02 Dec 2020)
Sequence version 1 (21 Jul 1986)
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Protein

Metalloproteinase inhibitor 1

Gene

TIMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.12 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi24Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partner1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei57Involved in metalloproteinase-bindingCombined sources1 Publication1
Sitei158Involved in metalloproteinase-bindingCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01033

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-1592389, Activation of Matrix Metalloproteinases
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6783783, Interleukin-10 signaling
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-8957275, Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P01033

Protein family/group databases

MEROPS protease database

More...MEROPSi		I35.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metalloproteinase inhibitor 1
Alternative name(s):
Erythroid-potentiating activity
Short name:
EPA
Fibroblast collagenase inhibitor
Short name:
Collagenase inhibitor
Tissue inhibitor of metalloproteinases 1
Short name:
TIMP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIMP1
Synonyms:CLGI, TIMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000102265.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:11820, TIMP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		305370, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01033

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25T → E, G, K, Q or R: Reduced interaction with metalloproteinase. 1 Publication1
Mutagenesisi25T → V: Normal interaction with metalloproteinase. 1 Publication1
Mutagenesisi30H → A: Nearly abolishes metalloproteinase inhibition. 1 Publication1
Mutagenesisi32Q → A: Nearly abolishes metalloproteinase inhibition. 1 Publication1
Mutagenesisi121T → L: Decreases protein flexibility and increases affinity for MMP14. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		7076

Open Targets

More...OpenTargetsi		ENSG00000102265

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36526

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01033, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TIMP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		135850

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 236 PublicationsAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003432324 – 207Metalloproteinase inhibitor 1Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 93PROSITE-ProRule annotation1 Publication
Disulfide bondi26 ↔ 1225 Publications
Disulfide bondi36 ↔ 1475 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00000253N-linked (GlcNAc...) (complex) asparagine4 Publications1
GlycosylationiCAR_000003101N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi150 ↔ 1975 Publications
Disulfide bondi155 ↔ 1605 Publications
Disulfide bondi168 ↔ 1895 Publications
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei178Phosphoserine; by FAM20C1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The activity of TIMP1 is dependent on the presence of disulfide bonds.5 Publications
N-glycosylated.7 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-680

Encyclopedia of Proteome Dynamics

More...EPDi		P01033

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P01033

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01033

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01033

PeptideAtlas

More...PeptideAtlasi		P01033

PRoteomics IDEntifications database

More...PRIDEi		P01033

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51310

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		367, 42 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P01033, 2 sites, 33 N-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01033

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01033

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P01033

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P01033

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in rheumatoid synovial fluid (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102265, Expressed in left coronary artery and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P01033, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01033, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000102265, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14.

Interacts with CD63; identified in a complex with CD63 and ITGB1.

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112932, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P01033

Database of interacting proteins

More...DIPi		DIP-1107N

Protein interaction database and analysis system

More...IntActi		P01033, 10 interactors

Molecular INTeraction database

More...MINTi		P01033

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000218388

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01033, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P01033

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01033

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P01033

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 147NTRPROSITE-ProRule annotationAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 27Involved in metalloproteinase-bindingCombined sources1 Publication4
Regioni90 – 91Involved in metalloproteinase-bindingCombined sources1 Publication2
Regioni179 – 180Involved in metalloproteinase-bindingCombined sources1 Publication2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protease inhibitor I35 (TIMP) family. [View classification]Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4745, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161081

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_084029_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01033

Identification of Orthologs from Complete Genome Data

More...OMAi		CTVFPCS

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01033

TreeFam database of animal gene trees

More...TreeFami		TF317409

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.50.120, 1 hit
3.90.370.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001134, Netrin_domain
IPR001820, TIMP
IPR008993, TIMP-like_OB-fold
IPR015611, TIMP1
IPR027465, TIMP_C
IPR030490, TIMP_CS

The PANTHER Classification System

More...PANTHERi		PTHR11844, PTHR11844, 1 hit
PTHR11844:SF20, PTHR11844:SF20, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00965, TIMP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00206, NTR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50189, NTR, 1 hit
PS00288, TIMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P01033-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPFEPLASG ILLLLWLIAP SRACTCVPPH PQTAFCNSDL VIRAKFVGTP 
        60         70         80         90        100
EVNQTTLYQR YEIKMTKMYK GFQALGDAAD IRFVYTPAME SVCGYFHRSH 
       110        120        130        140        150
NRSEEFLIAG KLQDGLLHIT TCSFVAPWNS LSLAQRRGFT KTYTVGCEEC 
       160        170        180        190        200
TVFPCLSIPC KLQSGTHCLW TDQLLQGSEK GFQSRHLACL PREPGLCTWQ 

SLRSQIA
Length:207
Mass (Da):23,171
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AE4F90FFAB2ECDC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5H9B5Q5H9B5_HUMAN
Metalloproteinase inhibitor 1
TIMP1
136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5H9B4Q5H9B4_HUMAN
Metalloproteinase inhibitor 1
TIMP1
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5H9A7Q5H9A7_HUMAN
Metalloproteinase inhibitor 1
TIMP1
143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y789H0Y789_HUMAN
Metalloproteinase inhibitor 1
TIMP1
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23A → P in CAA26443 (PubMed:3839290).Curated1
Sequence conflicti44A → P in BAA01913 (Ref. 12) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X03124 mRNA Translation: CAA26902.1
X02598 mRNA Translation: CAA26443.1
M12670 mRNA Translation: AAA52436.1
M59906 mRNA Translation: AAA63234.1
S68252 mRNA Translation: AAD14009.1
BC000866 mRNA Translation: AAH00866.1
L47361 Genomic DNA Translation: AAA75558.1
D11139 Genomic DNA Translation: BAA01913.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14281.1

Protein sequence database of the Protein Information Resource

More...PIRi		A93372, ZYHUEP

NCBI Reference Sequences

More...RefSeqi		NP_003245.1, NM_003254.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000218388; ENSP00000218388; ENSG00000102265

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7076

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7076

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03124 mRNA Translation: CAA26902.1
X02598 mRNA Translation: CAA26443.1
M12670 mRNA Translation: AAA52436.1
M59906 mRNA Translation: AAA63234.1
S68252 mRNA Translation: AAD14009.1
BC000866 mRNA Translation: AAH00866.1
L47361 Genomic DNA Translation: AAA75558.1
D11139 Genomic DNA Translation: BAA01913.1
CCDSiCCDS14281.1
PIRiA93372, ZYHUEP
RefSeqiNP_003245.1, NM_003254.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D2BNMR-A24-149[»]
1LQNmodel-A1-207[»]
1OO9NMR-B24-149[»]
1UEAX-ray2.80B/D24-207[»]
2J0TX-ray2.54D/E/F24-149[»]
3MA2X-ray2.05B/C24-148[»]
3V96X-ray1.90A24-207[»]
6MAVX-ray2.37B24-207[»]
6N9DX-ray2.67B24-207[»]
BMRBiP01033
SMRiP01033
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112932, 15 interactors
CORUMiP01033
DIPiDIP-1107N
IntActiP01033, 10 interactors
MINTiP01033
STRINGi9606.ENSP00000218388

Protein family/group databases

MEROPSiI35.001

PTM databases

GlyConnecti367, 42 N-Linked glycans (2 sites)
GlyGeniP01033, 2 sites, 33 N-linked glycans (2 sites)
iPTMnetiP01033
PhosphoSitePlusiP01033
SwissPalmiP01033
UniCarbKBiP01033

Polymorphism and mutation databases

BioMutaiTIMP1
DMDMi135850

Proteomic databases

CPTACiCPTAC-680
EPDiP01033
jPOSTiP01033
MassIVEiP01033
PaxDbiP01033
PeptideAtlasiP01033
PRIDEiP01033
ProteomicsDBi51310

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P01033, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11411, 1067 antibodies

The DNASU plasmid repository

More...DNASUi		7076

Genome annotation databases

EnsembliENST00000218388; ENSP00000218388; ENSG00000102265
GeneIDi7076
KEGGihsa:7076

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7076
DisGeNETi7076
EuPathDBiHostDB:ENSG00000102265.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		TIMP1
HGNCiHGNC:11820, TIMP1
HPAiENSG00000102265, Tissue enhanced (lymphoid)
MIMi305370, gene
neXtProtiNX_P01033
OpenTargetsiENSG00000102265
PharmGKBiPA36526

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4745, Eukaryota
GeneTreeiENSGT00940000161081
HOGENOMiCLU_084029_0_0_1
InParanoidiP01033
OMAiCTVFPCS
PhylomeDBiP01033
TreeFamiTF317409

Enzyme and pathway databases

PathwayCommonsiP01033
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-1592389, Activation of Matrix Metalloproteinases
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6783783, Interleukin-10 signaling
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-8957275, Post-translational protein phosphorylation
SIGNORiP01033

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7076, 4 hits in 470 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TIMP1, human
EvolutionaryTraceiP01033

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TIMP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7076
PharosiP01033, Tbio

Protein Ontology

More...PROi		PR:P01033
RNActiP01033, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102265, Expressed in left coronary artery and 236 other tissues
ExpressionAtlasiP01033, baseline and differential
GenevisibleiP01033, HS

Family and domain databases

Gene3Di2.40.50.120, 1 hit
3.90.370.10, 1 hit
InterProiView protein in InterPro
IPR001134, Netrin_domain
IPR001820, TIMP
IPR008993, TIMP-like_OB-fold
IPR015611, TIMP1
IPR027465, TIMP_C
IPR030490, TIMP_CS
PANTHERiPTHR11844, PTHR11844, 1 hit
PTHR11844:SF20, PTHR11844:SF20, 1 hit
PfamiView protein in Pfam
PF00965, TIMP, 1 hit
SMARTiView protein in SMART
SM00206, NTR, 1 hit
SUPFAMiSSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS50189, NTR, 1 hit
PS00288, TIMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIMP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01033
Secondary accession number(s): Q14252, Q9UCU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 2, 2020
This is version 221 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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