Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Complement C5

Gene

C5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.1 Publication

GO - Molecular functioni

  • chemokine activity Source: ProtInc
  • endopeptidase inhibitor activity Source: InterPro
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BRENDAi3.4.21.43 2681
ReactomeiR-HSA-166665 Terminal pathway of complement
R-HSA-174577 Activation of C3 and C5
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-977606 Regulation of Complement cascade
SIGNORiP01031

Protein family/group databases

MEROPSiI39.952

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C5
Alternative name(s):
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Cleaved into the following 4 chains:
Gene namesi
Name:C5
Synonyms:CPAMD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106804.7
HGNCiHGNC:1331 C5
MIMi120900 gene
neXtProtiNX_P01031

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane attack complex, Secreted

Pathology & Biotechi

Involvement in diseasei

Complement component 5 deficiency (C5D)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
See also OMIM:609536
An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele.1 Publication

Organism-specific databases

DisGeNETi727
MalaCardsiC5
MIMi609536 phenotype
615749 phenotype
OpenTargetsiENSG00000106804
Orphaneti169150 Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25911

Chemistry databases

ChEMBLiCHEMBL2364163
DrugBankiDB01257 Eculizumab
DB00028 Immune Globulin Human

Polymorphism and mutation databases

BioMutaiC5
DMDMi166900096

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000598519 – 673Complement C5 beta chainAdd BLAST655
PropeptideiPRO_0000005986674 – 6771 Publication4
ChainiPRO_0000005987678 – 1676Complement C5 alpha chainAdd BLAST999
ChainiPRO_0000005988678 – 751C5a anaphylatoxinAdd BLAST74
ChainiPRO_0000005989752 – 1676Complement C5 alpha' chainAdd BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi567 ↔ 810
Disulfide bondi634 ↔ 669
Disulfide bondi698 ↔ 724
Disulfide bondi699 ↔ 731
Disulfide bondi711 ↔ 732
Glycosylationi741N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi856 ↔ 883
Disulfide bondi866 ↔ 1527
Glycosylationi911N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi1101 ↔ 1159
Glycosylationi1115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1375 ↔ 1505
Disulfide bondi1405 ↔ 1474
Disulfide bondi1520 ↔ 1525
Disulfide bondi1532 ↔ 1606
Disulfide bondi1553 ↔ 1676
Glycosylationi1630N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1654 ↔ 1657

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01031
MaxQBiP01031
PaxDbiP01031
PeptideAtlasiP01031
PRIDEiP01031
ProteomicsDBi12624
51309

PTM databases

CarbonylDBiP01031
GlyConnecti1147
iPTMnetiP01031
PhosphoSitePlusiP01031

Miscellaneous databases

PMAP-CutDBiP01031

Expressioni

Gene expression databases

BgeeiENSG00000106804 Expressed in 179 organ(s), highest expression level in liver
CleanExiHS_C5
GenevisibleiP01031 HS

Organism-specific databases

HPAiHPA029339

Interactioni

Subunit structurei

C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). The C5a anaphylatoxin interacts with C5AR1. Interacts with tick complement inhibitor.4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107188, 8 interactors
IntActiP01031, 11 interactors
MINTiP01031
STRINGi9606.ENSP00000223642

Structurei

Secondary structure

11676
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01031
SMRiP01031
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01031

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini698 – 732Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST35
Domaini1532 – 1676NTRPROSITE-ProRule annotationAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni692 – 721Involved in C5AR1 binding1 PublicationAdd BLAST30

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00760000118982
HOGENOMiHOG000231860
HOVERGENiHBG098067
InParanoidiP01031
KOiK03994
OMAiYVFHYLE
OrthoDBiEOG091G00BU
PhylomeDBiP01031
TreeFamiTF313285

Family and domain databases

CDDicd00017 ANATO, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011626 A2M_comp
IPR002890 A2M_N
IPR011625 A2M_N_2
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR037562 Complement_C5
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11412:SF83 PTHR11412:SF83, 1 hit
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07678 A2M_comp, 1 hit
PF01835 A2M_N, 1 hit
PF07703 A2M_N_2, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01759 NTR, 1 hit
PRINTSiPR00004 ANAPHYLATOXN
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit
SUPFAMiSSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01031-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLGILCFL IFLGKTWGQE QTYVISAPKI FRVGASENIV IQVYGYTEAF
60 70 80 90 100
DATISIKSYP DKKFSYSSGH VHLSSENKFQ NSAILTIQPK QLPGGQNPVS
110 120 130 140 150
YVYLEVVSKH FSKSKRMPIT YDNGFLFIHT DKPVYTPDQS VKVRVYSLND
160 170 180 190 200
DLKPAKRETV LTFIDPEGSE VDMVEEIDHI GIISFPDFKI PSNPRYGMWT
210 220 230 240 250
IKAKYKEDFS TTGTAYFEVK EYVLPHFSVS IEPEYNFIGY KNFKNFEITI
260 270 280 290 300
KARYFYNKVV TEADVYITFG IREDLKDDQK EMMQTAMQNT MLINGIAQVT
310 320 330 340 350
FDSETAVKEL SYYSLEDLNN KYLYIAVTVI ESTGGFSEEA EIPGIKYVLS
360 370 380 390 400
PYKLNLVATP LFLKPGIPYP IKVQVKDSLD QLVGGVPVTL NAQTIDVNQE
410 420 430 440 450
TSDLDPSKSV TRVDDGVASF VLNLPSGVTV LEFNVKTDAP DLPEENQARE
460 470 480 490 500
GYRAIAYSSL SQSYLYIDWT DNHKALLVGE HLNIIVTPKS PYIDKITHYN
510 520 530 540 550
YLILSKGKII HFGTREKFSD ASYQSINIPV TQNMVPSSRL LVYYIVTGEQ
560 570 580 590 600
TAELVSDSVW LNIEEKCGNQ LQVHLSPDAD AYSPGQTVSL NMATGMDSWV
610 620 630 640 650
ALAAVDSAVY GVQRGAKKPL ERVFQFLEKS DLGCGAGGGL NNANVFHLAG
660 670 680 690 700
LTFLTNANAD DSQENDEPCK EILRPRRTLQ KKIEEIAAKY KHSVVKKCCY
710 720 730 740 750
DGACVNNDET CEQRAARISL GPRCIKAFTE CCVVASQLRA NISHKDMQLG
760 770 780 790 800
RLHMKTLLPV SKPEIRSYFP ESWLWEVHLV PRRKQLQFAL PDSLTTWEIQ
810 820 830 840 850
GVGISNTGIC VADTVKAKVF KDVFLEMNIP YSVVRGEQIQ LKGTVYNYRT
860 870 880 890 900
SGMQFCVKMS AVEGICTSES PVIDHQGTKS SKCVRQKVEG SSSHLVTFTV
910 920 930 940 950
LPLEIGLHNI NFSLETWFGK EILVKTLRVV PEGVKRESYS GVTLDPRGIY
960 970 980 990 1000
GTISRRKEFP YRIPLDLVPK TEIKRILSVK GLLVGEILSA VLSQEGINIL
1010 1020 1030 1040 1050
THLPKGSAEA ELMSVVPVFY VFHYLETGNH WNIFHSDPLI EKQKLKKKLK
1060 1070 1080 1090 1100
EGMLSIMSYR NADYSYSVWK GGSASTWLTA FALRVLGQVN KYVEQNQNSI
1110 1120 1130 1140 1150
CNSLLWLVEN YQLDNGSFKE NSQYQPIKLQ GTLPVEAREN SLYLTAFTVI
1160 1170 1180 1190 1200
GIRKAFDICP LVKIDTALIK ADNFLLENTL PAQSTFTLAI SAYALSLGDK
1210 1220 1230 1240 1250
THPQFRSIVS ALKREALVKG NPPIYRFWKD NLQHKDSSVP NTGTARMVET
1260 1270 1280 1290 1300
TAYALLTSLN LKDINYVNPV IKWLSEEQRY GGGFYSTQDT INAIEGLTEY
1310 1320 1330 1340 1350
SLLVKQLRLS MDIDVSYKHK GALHNYKMTD KNFLGRPVEV LLNDDLIVST
1360 1370 1380 1390 1400
GFGSGLATVH VTTVVHKTST SEEVCSFYLK IDTQDIEASH YRGYGNSDYK
1410 1420 1430 1440 1450
RIVACASYKP SREESSSGSS HAVMDISLPT GISANEEDLK ALVEGVDQLF
1460 1470 1480 1490 1500
TDYQIKDGHV ILQLNSIPSS DFLCVRFRIF ELFEVGFLSP ATFTVYEYHR
1510 1520 1530 1540 1550
PDKQCTMFYS TSNIKIQKVC EGAACKCVEA DCGQMQEELD LTISAETRKQ
1560 1570 1580 1590 1600
TACKPEIAYA YKVSITSITV ENVFVKYKAT LLDIYKTGEA VAEKDSEITF
1610 1620 1630 1640 1650
IKKVTCTNAE LVKGRQYLIM GKEALQIKYN FSFRYIYPLD SLTWIEYWPR
1660 1670
DTTCSSCQAF LANLDEFAED IFLNGC
Length:1,676
Mass (Da):188,305
Last modified:February 5, 2008 - v4
Checksum:iA7589E352F74672A
GO

Polymorphismi

C5 variants are responsible for poor response to eculizumab [MIMi:615749]. Eculizumab is a monoclonal antibody highly effective in reducing intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria. It specifically binds to the terminal complement protein C5, inhibits its cleavage into C5a and C5b, and prevents the formations of the cytolytic complement pore (PubMed:24521109).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038735145V → I1 PublicationCorresponds to variant dbSNP:rs17216529Ensembl.1
Natural variantiVAR_048822354L → M. Corresponds to variant dbSNP:rs34552775Ensembl.1
Natural variantiVAR_023946389T → I2 Publications1
Natural variantiVAR_038736449R → G1 PublicationCorresponds to variant dbSNP:rs2230213Ensembl.1
Natural variantiVAR_001996518F → S. 1
Natural variantiVAR_014574802V → I7 PublicationsCorresponds to variant dbSNP:rs17611EnsemblClinVar.1
Natural variantiVAR_071067885R → C Polymorphism associated with poor response to eculizumab in PNH patients. 1 PublicationCorresponds to variant dbSNP:rs373359894EnsemblClinVar.1
Natural variantiVAR_071068885R → H Polymorphism associated with poor response to eculizumab in PNH patients. 1 PublicationCorresponds to variant dbSNP:rs56040400EnsemblClinVar.1
Natural variantiVAR_038737928R → Q1 PublicationCorresponds to variant dbSNP:rs41309892Ensembl.1
Natural variantiVAR_038738933G → V1 PublicationCorresponds to variant dbSNP:rs41309902Ensembl.1
Natural variantiVAR_048823966D → Y Polymorphism; confirmed at protein level. 1 PublicationCorresponds to variant dbSNP:rs2230212Ensembl.1
Natural variantiVAR_0387391033I → T1 PublicationCorresponds to variant dbSNP:rs41311881Ensembl.1
Natural variantiVAR_0387401037D → N1 PublicationCorresponds to variant dbSNP:rs41311883Ensembl.1
Natural variantiVAR_0387411043Q → K1 PublicationCorresponds to variant dbSNP:rs41311887Ensembl.1
Natural variantiVAR_0145751053M → L. Corresponds to variant dbSNP:rs17609Ensembl.1
Natural variantiVAR_0145761310S → N1 PublicationCorresponds to variant dbSNP:rs17610Ensembl.1
Natural variantiVAR_0488241365V → A. Corresponds to variant dbSNP:rs16910245Ensembl.1
Natural variantiVAR_0145771437E → D1 PublicationCorresponds to variant dbSNP:rs17612EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57729 mRNA Translation: AAA51925.1
DQ400449 Genomic DNA Translation: ABD48959.1
CH471090 Genomic DNA Translation: EAW87480.1
BC113738 mRNA Translation: AAI13739.1
BC113740 mRNA Translation: AAI13741.1
M65134 mRNA Translation: AAA51856.1
CCDSiCCDS6826.1
PIRiA40075 C5HU
RefSeqiNP_001304092.1, NM_001317163.1
NP_001726.2, NM_001735.2
UniGeneiHs.494997

Genome annotation databases

EnsembliENST00000223642; ENSP00000223642; ENSG00000106804
GeneIDi727
KEGGihsa:727
UCSCiuc004bkv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

C5base

C5 mutation db

Wikipedia

Complement C5 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57729 mRNA Translation: AAA51925.1
DQ400449 Genomic DNA Translation: ABD48959.1
CH471090 Genomic DNA Translation: EAW87480.1
BC113738 mRNA Translation: AAI13739.1
BC113740 mRNA Translation: AAI13741.1
M65134 mRNA Translation: AAA51856.1
CCDSiCCDS6826.1
PIRiA40075 C5HU
RefSeqiNP_001304092.1, NM_001317163.1
NP_001726.2, NM_001735.2
UniGeneiHs.494997

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CFANMR-A679-747[»]
1KJSNMR-A679-751[»]
1XWENMR-A1530-1676[»]
3CU7X-ray3.10A/B1-1676[»]
3HQAX-ray2.59A/B679-750[»]
3HQBX-ray3.30A/B679-750[»]
3KLSX-ray3.60A/B1-1676[»]
3KM9X-ray4.20A/B1-1676[»]
3PRXX-ray4.30A/C1-1676[»]
3PVMX-ray4.30A/C1-1676[»]
4A5WX-ray3.50A19-1676[»]
4E0SX-ray4.21A1-1676[»]
4P39X-ray2.40A/B/C/D678-747[»]
4UU9X-ray2.12C/D678-751[»]
5B4PX-ray2.40B/D678-751[»]
5B71X-ray2.11E/F20-124[»]
5HCCX-ray2.59A679-1676[»]
B19-674[»]
5HCDX-ray2.98A679-1676[»]
B19-674[»]
5HCEX-ray3.12A679-1676[»]
B19-674[»]
5I5KX-ray4.20A/B1-1676[»]
ProteinModelPortaliP01031
SMRiP01031
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107188, 8 interactors
IntActiP01031, 11 interactors
MINTiP01031
STRINGi9606.ENSP00000223642

Chemistry databases

ChEMBLiCHEMBL2364163
DrugBankiDB01257 Eculizumab
DB00028 Immune Globulin Human

Protein family/group databases

MEROPSiI39.952

PTM databases

CarbonylDBiP01031
GlyConnecti1147
iPTMnetiP01031
PhosphoSitePlusiP01031

Polymorphism and mutation databases

BioMutaiC5
DMDMi166900096

Proteomic databases

EPDiP01031
MaxQBiP01031
PaxDbiP01031
PeptideAtlasiP01031
PRIDEiP01031
ProteomicsDBi12624
51309

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223642; ENSP00000223642; ENSG00000106804
GeneIDi727
KEGGihsa:727
UCSCiuc004bkv.4 human

Organism-specific databases

CTDi727
DisGeNETi727
EuPathDBiHostDB:ENSG00000106804.7
GeneCardsiC5
H-InvDBiHIX0025739
HGNCiHGNC:1331 C5
HPAiHPA029339
MalaCardsiC5
MIMi120900 gene
609536 phenotype
615749 phenotype
neXtProtiNX_P01031
OpenTargetsiENSG00000106804
Orphaneti169150 Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25911
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00760000118982
HOGENOMiHOG000231860
HOVERGENiHBG098067
InParanoidiP01031
KOiK03994
OMAiYVFHYLE
OrthoDBiEOG091G00BU
PhylomeDBiP01031
TreeFamiTF313285

Enzyme and pathway databases

BRENDAi3.4.21.43 2681
ReactomeiR-HSA-166665 Terminal pathway of complement
R-HSA-174577 Activation of C3 and C5
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-977606 Regulation of Complement cascade
SIGNORiP01031

Miscellaneous databases

EvolutionaryTraceiP01031
GeneWikiiComplement_component_5
GenomeRNAii727
PMAP-CutDBiP01031
PROiPR:P01031
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106804 Expressed in 179 organ(s), highest expression level in liver
CleanExiHS_C5
GenevisibleiP01031 HS

Family and domain databases

CDDicd00017 ANATO, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011626 A2M_comp
IPR002890 A2M_N
IPR011625 A2M_N_2
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR037562 Complement_C5
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11412:SF83 PTHR11412:SF83, 1 hit
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07678 A2M_comp, 1 hit
PF01835 A2M_N, 1 hit
PF07703 A2M_N_2, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01759 NTR, 1 hit
PRINTSiPR00004 ANAPHYLATOXN
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit
SUPFAMiSSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO5_HUMAN
AccessioniPrimary (citable) accession number: P01031
Secondary accession number(s): Q14CJ0, Q27I61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 211 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again