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Entry version 184 (16 Oct 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Complement C4-B

Gene

C4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens (By similarity).By similarity

Miscellaneous

C4 is a major histocompatibility complex class-III protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement pathway, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-166663 Initial triggering of complement
R-MMU-174577 Activation of C3 and C5
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-977606 Regulation of Complement cascade

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement C4-B
Cleaved into the following 4 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C4b
Synonyms:C4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88228 C4b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Secreted, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Add BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000597320 – 673Complement C4 beta chainAdd BLAST654
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000005974674 – 6774
ChainiPRO_0000005975678 – 1443Complement C4 alpha chainAdd BLAST766
ChainiPRO_0000005976678 – 753C4a anaphylatoxinAdd BLAST76
PropeptideiPRO_00000059771444 – 14474
ChainiPRO_00000059781448 – 1738Complement C4 gamma chainAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi700 ↔ 726By similarity
Disulfide bondi701 ↔ 733By similarity
Disulfide bondi714 ↔ 734By similarity
Glycosylationi743N-linked (GlcNAc...) asparagine1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1006 ↔ 1009Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi1324N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1387N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1413SulfotyrosineBy similarity1
Modified residuei1416SulfotyrosineBy similarity1
Modified residuei1417SulfotyrosineBy similarity1
Disulfide bondi1589 ↔ 1667By similarity
Disulfide bondi1612 ↔ 1736By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Sulfation, Thioester bond

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3339

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P01029

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P01029

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01029

PRoteomics IDEntifications database

More...
PRIDEi
P01029

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
720

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01029

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01029

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P01029

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000073418 Expressed in 29 organ(s), highest expression level in epididymal fat pad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01029 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01029 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198420, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P01029, 2 interactors

Molecular INTeraction database

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MINTi
P01029

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000069418

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01029

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini700 – 734Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST35
Domaini1589 – 1736NTRPROSITE-ProRule annotationAdd BLAST148

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366 Eukaryota
ENOG410XRED LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155739

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01029

KEGG Orthology (KO)

More...
KOi
K03989

Identification of Orthologs from Complete Genome Data

More...
OMAi
TWEIHAV

Database of Orthologous Groups

More...
OrthoDBi
28894at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00017 ANATO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR037569 Complement_C4A
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR11412:SF86 PTHR11412:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF01759 NTR, 1 hit
PF07678 TED_complement, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00004 ANAPHYLATOXN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01029-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLWGLAWV FSFCASSLQK PRLLLFSPSV VNLGTPLSVG VQLLDAPPGQ
60 70 80 90 100
EVKGSVFLRN PKGGSCSPKK DFKLSSGDDF VLLSLEVPLE DVRSCGLFDL
110 120 130 140 150
RRAPHIQLVA QSPWLRNTAF KATETQGVNL LFSSRRGHIF VQTDQPIYNP
160 170 180 190 200
GQRVRYRVFA LDQKMRPSTD FLTITVENSH GLRVLKKEIF TSTSIFQDAF
210 220 230 240 250
TIPDISEPGT WKISARFSDG LESNRSTHFE VKKYVLPNFE VKITPWKPYI
260 270 280 290 300
LMVPSNSDEI QLDIQARYIY GKPVQGVAYT RFALMDEQGK RTFLRGLETQ
310 320 330 340 350
AKLVEGRTHI SISKDQFQAA LDKINIGVRD LEGLRLYAAT AVIESPGGEM
360 370 380 390 400
EEAELTSWRF VSSAFSLDLS RTKRHLVPGA HFLLQALVQE MSGSEASNVP
410 420 430 440 450
VKVSATLVSG SDSQVLDIQQ STNGIGQVSI SFPIPPTVTE LRLLVSAGSL
460 470 480 490 500
YPAIARLTVQ APPSRGTGFL SIEPLDPRSP SVGDTFILNL QPVGIPAPTF
510 520 530 540 550
SHYYYMIISR GQIMAMGREP RKTVTSVSVL VDHQLAPSFY FVAYFYHQGH
560 570 580 590 600
PVANSLLINI QSRDCEGKLQ LKVDGAKEYR NADMMKLRIQ TDSKALVALG
610 620 630 640 650
AVDMALYAVG GRSHKPLDMS KVFEVINSYN VGCGPGGGDD ALQVFQDAGL
660 670 680 690 700
AFSDGDRLTQ TREDLSCPKE KKSRQKRNVN FQKAVSEKLG QYSSPDAKRC
710 720 730 740 750
CQDGMTKLPM KRTCEQRAAR VPQQACREPF LSCCKFAEDL RRNQTRSQAH
760 770 780 790 800
LARNNHNMLQ EEDLIDEDDI LVRTSFPENW LWRVEPVDSS KLLTVWLPDS
810 820 830 840 850
MTTWEIHGVS LSKSKGLCVA KPTRVRVFRK FHLHLRLPIS IRRFEQFELR
860 870 880 890 900
PVLYNYLNDD VAVSVHVTPV EGLCLAGGGM MAQQVTVPAG SARPVAFSVV
910 920 930 940 950
PTAAANVPLK VVARGVFDLG DAVSKILQIE KEGAIHREEL VYNLDPLNNL
960 970 980 990 1000
GRTLEIPGSS DPNIVPDGDF SSLVRVTASE PLETMGSEGA LSPGGVASLL
1010 1020 1030 1040 1050
RLPQGCAEQT MIYLAPTLTA SNYLDRTEQW SKLSPETKDH AVDLIQKGYM
1060 1070 1080 1090 1100
RIQQFRKNDG SFGAWLHRDS STWLTAFVLK ILSLAQEQVG NSPEKLQETA
1110 1120 1130 1140 1150
SWLLAQQLGD GSFHDPCPVI HRAMQGGLVG SDETVALTAF VVIALHHGLD
1160 1170 1180 1190 1200
VFQDDDAKQL KNRVEASITK ANSFLGQKAS AGLLGAHAAA ITAYALTLTK
1210 1220 1230 1240 1250
ASEDLRNVAH NSLMAMAEET GEHLYWGLVL GSQDKVVLRP TAPRSPTEPV
1260 1270 1280 1290 1300
PQAPALWIET TAYALLHLLL REGKGKMADK AASWLTHQGS FHGAFRSTQD
1310 1320 1330 1340 1350
TVVTLDALSA YWIASHTTEE KALNVTLSSM GRNGLKTHGL HLNNHQVKGL
1360 1370 1380 1390 1400
EEELKFSLGS TISVKVEGNS KGTLKILRTY NVLDMKNTTC QDLQIEVKVT
1410 1420 1430 1440 1450
GAVEYAWDAN EDYEDYYDMP AADDPSVPLQ PVTPLQLFEG RRSRRRREAP
1460 1470 1480 1490 1500
KVVEEQESRV QYTVCIWRNG KLGLSGMAIA DITLLSGFHA LRADLEKLTS
1510 1520 1530 1540 1550
LSDRYVSHFE TDGPHVLLYF DSVPTTRECV GFGASQEVVV GLVQPSSAVL
1560 1570 1580 1590 1600
YDYYSPDHKC SVFYAAPTKS QLLATLCSGD VCQCAEGKCP RLLRSLERRV
1610 1620 1630 1640 1650
EDKDGYRMRF ACYYPRVEYG FTVKVLREDG RAAFRLFESK ITQVLHFRKD
1660 1670 1680 1690 1700
TMASIGQTRN FLSRASCRLR LEPNKEYLIM GMDGETSDNK GDPQYLLDSN
1710 1720 1730
TWIEEMPSEQ MCKSTRHRAA CFQLKDFLME FSSRGCQV
Length:1,738
Mass (Da):192,915
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCC7580209029E88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZS2G3UZS2_MOUSE
Complement C4-B
C4b
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132F → Y in AAA39557 (PubMed:2993295).Curated1
Sequence conflicti177E → G in BAE34429 (PubMed:16141072).Curated1
Sequence conflicti283A → V in BAE34429 (PubMed:16141072).Curated1
Sequence conflicti327G → E in AAA39557 (PubMed:2993295).Curated1
Sequence conflicti440E → K in AAH67394 (PubMed:15489334).Curated1
Sequence conflicti440E → K in AAH67409 (PubMed:15489334).Curated1
Sequence conflicti570Q → E in AAA39557 (PubMed:2993295).Curated1
Sequence conflicti570Q → E in BAE34280 (PubMed:16141072).Curated1
Sequence conflicti604M → T in AAA39557 (PubMed:2993295).Curated1
Sequence conflicti604M → T in AAA39506 (PubMed:3862104).Curated1
Sequence conflicti604M → T in AAA39561 (PubMed:2777798).Curated1
Sequence conflicti604M → T in BAE34280 (PubMed:16141072).Curated1
Sequence conflicti604M → T in BAE34429 (PubMed:16141072).Curated1
Sequence conflicti604M → T in AAH67394 (PubMed:15489334).Curated1
Sequence conflicti604M → T in AAH67409 (PubMed:15489334).Curated1
Sequence conflicti639D → G in BAE34429 (PubMed:16141072).Curated1
Sequence conflicti758M → I in BAE34280 (PubMed:16141072).Curated1
Sequence conflicti838P → R in AAA39557 (PubMed:2993295).Curated1
Sequence conflicti916V → I in BAE34280 (PubMed:16141072).Curated1
Sequence conflicti1077F → S in AAH67394 (PubMed:15489334).Curated1
Sequence conflicti1077F → S in AAH67409 (PubMed:15489334).Curated1
Sequence conflicti1119V → A in AAC42021 (PubMed:3856857).Curated1
Sequence conflicti1190A → T in AAC42021 (PubMed:3856857).Curated1
Sequence conflicti1206R → Q in BAE34280 (PubMed:16141072).Curated1
Sequence conflicti1206R → Q in BAE34429 (PubMed:16141072).Curated1
Sequence conflicti1206R → Q in AAH67394 (PubMed:15489334).Curated1
Sequence conflicti1206R → Q in AAH67409 (PubMed:15489334).Curated1
Sequence conflicti1206R → Q in AAA40487 (PubMed:2459207).Curated1
Sequence conflicti1290S → N in AAC42022 (PubMed:6149581).Curated1
Sequence conflicti1324N → K in AAA39506 (PubMed:3862104).Curated1
Sequence conflicti1324N → K in AAA39561 (PubMed:2777798).Curated1
Sequence conflicti1324N → K in AAC42021 (PubMed:3856857).Curated1
Sequence conflicti1365K → E in BAE34429 (PubMed:16141072).Curated1
Sequence conflicti1401G → S in AAA39554 (PubMed:6192448).Curated1
Sequence conflicti1442R → K in AAA39557 (PubMed:2993295).Curated1
Sequence conflicti1453V → A in AAA39506 (PubMed:3862104).Curated1
Sequence conflicti1453V → A in AAA39561 (PubMed:2777798).Curated1
Sequence conflicti1453V → A in BAE34429 (PubMed:16141072).Curated1
Sequence conflicti1453V → A in AAA39554 (PubMed:6192448).Curated1
Sequence conflicti1456Q → R in BAE34429 (PubMed:16141072).Curated1
Sequence conflicti1586E → Q in CAA28936 (PubMed:3008092).Curated1
Sequence conflicti1611A → T in AAC05279 (PubMed:14656967).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M11789 Genomic DNA Translation: AAA39557.1
M11729 mRNA Translation: AAA39506.1
M17440 Genomic DNA Translation: AAA39561.1
AK157954 mRNA Translation: BAE34280.1
AK158256 mRNA Translation: BAE34429.1
AF049850 Genomic DNA Translation: AAC05279.1
CT573030 Genomic DNA No translation available.
BC067394 mRNA Translation: AAH67394.1
BC067409 mRNA Translation: AAH67409.1
M12968 Genomic DNA Translation: AAA39558.1
M12969 Genomic DNA Translation: AAA39559.1
M14225 Genomic DNA Translation: AAA39563.1
X05314 mRNA Translation: CAA28936.1
M12970 mRNA Translation: AAA39555.1
M12972 mRNA Translation: AAA39556.1
M23186 Genomic DNA Translation: AAA40487.1
X55493 Genomic DNA Translation: CAA39112.1
X55495 Genomic DNA Translation: CAA39114.1
K02798 mRNA Translation: AAC42021.1
K02799 mRNA Translation: AAC42022.1
K00019 mRNA Translation: AAA39554.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28657.1

Protein sequence database of the Protein Information Resource

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PIRi
A24558
A29176

NCBI Reference Sequences

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RefSeqi
NP_033910.2, NM_009780.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000069507; ENSMUSP00000069418; ENSMUSG00000073418

Database of genes from NCBI RefSeq genomes

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GeneIDi
12268

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:12268

UCSC genome browser

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UCSCi
uc008cdk.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11789 Genomic DNA Translation: AAA39557.1
M11729 mRNA Translation: AAA39506.1
M17440 Genomic DNA Translation: AAA39561.1
AK157954 mRNA Translation: BAE34280.1
AK158256 mRNA Translation: BAE34429.1
AF049850 Genomic DNA Translation: AAC05279.1
CT573030 Genomic DNA No translation available.
BC067394 mRNA Translation: AAH67394.1
BC067409 mRNA Translation: AAH67409.1
M12968 Genomic DNA Translation: AAA39558.1
M12969 Genomic DNA Translation: AAA39559.1
M14225 Genomic DNA Translation: AAA39563.1
X05314 mRNA Translation: CAA28936.1
M12970 mRNA Translation: AAA39555.1
M12972 mRNA Translation: AAA39556.1
M23186 Genomic DNA Translation: AAA40487.1
X55493 Genomic DNA Translation: CAA39112.1
X55495 Genomic DNA Translation: CAA39114.1
K02798 mRNA Translation: AAC42021.1
K02799 mRNA Translation: AAC42022.1
K00019 mRNA Translation: AAA39554.1
CCDSiCCDS28657.1
PIRiA24558
A29176
RefSeqiNP_033910.2, NM_009780.2

3D structure databases

SMRiP01029
ModBaseiSearch...

Protein-protein interaction databases

BioGridi198420, 1 interactor
IntActiP01029, 2 interactors
MINTiP01029
STRINGi10090.ENSMUSP00000069418

Protein family/group databases

MEROPSiI39.951

PTM databases

GlyConnecti720
iPTMnetiP01029
PhosphoSitePlusiP01029
SwissPalmiP01029

Proteomic databases

CPTACinon-CPTAC-3339
jPOSTiP01029
MaxQBiP01029
PaxDbiP01029
PRIDEiP01029

Genome annotation databases

EnsembliENSMUST00000069507; ENSMUSP00000069418; ENSMUSG00000073418
GeneIDi12268
KEGGimmu:12268
UCSCiuc008cdk.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
721
MGIiMGI:88228 C4b

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00940000155739
InParanoidiP01029
KOiK03989
OMAiTWEIHAV
OrthoDBi28894at2759
TreeFamiTF313285

Enzyme and pathway databases

ReactomeiR-MMU-166663 Initial triggering of complement
R-MMU-174577 Activation of C3 and C5
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C4b mouse

Protein Ontology

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PROi
PR:P01029

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000073418 Expressed in 29 organ(s), highest expression level in epididymal fat pad
ExpressionAtlasiP01029 baseline and differential
GenevisibleiP01029 MM

Family and domain databases

CDDicd00017 ANATO, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR037569 Complement_C4A
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11412:SF86 PTHR11412:SF86, 1 hit
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF01759 NTR, 1 hit
PF07678 TED_complement, 1 hit
PRINTSiPR00004 ANAPHYLATOXN
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit
SUPFAMiSSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO4B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01029
Secondary accession number(s): E9QKK7
, O70346, Q31201, Q3TYY1, Q3TZC9, Q61372, Q61859, Q62353, Q6NWV8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 184 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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