UniProtKB - P01027 (CO3_MOUSE)
Complement C3
C3
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1663 | Coordinates Mg2+ for interaction with Complement factor B Bb fragmentBy similarity | 1 |
GO - Molecular functioni
- C5L2 anaphylatoxin chemotactic receptor binding Source: UniProtKB
- endopeptidase inhibitor activity Source: InterPro
- lipid binding Source: MGI
GO - Biological processi
- amyloid-beta clearance Source: ARUK-UCL
- blood coagulation Source: MGI
- cell surface receptor signaling pathway involved in cell-cell signaling Source: ARUK-UCL
- complement activation Source: MGI
- complement activation, alternative pathway Source: UniProtKB-KW
- complement activation, classical pathway Source: UniProtKB-KW
- complement-dependent cytotoxicity Source: MGI
- complement-mediated synapse pruning Source: ARUK-UCL
- fatty acid metabolic process Source: UniProtKB-KW
- inflammatory response Source: UniProtKB-KW
- neuron remodeling Source: ARUK-UCL
- oviduct epithelium development Source: MGI
- positive regulation of activation of membrane attack complex Source: BHF-UCL
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of apoptotic cell clearance Source: MGI
- positive regulation of developmental growth Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: MGI
- positive regulation of glucose transmembrane transport Source: UniProtKB
- positive regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of lipid storage Source: UniProtKB
- positive regulation of phagocytosis Source: MGI
- positive regulation of phagocytosis, engulfment Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of receptor-mediated endocytosis Source: ARUK-UCL
- positive regulation of type IIa hypersensitivity Source: MGI
- positive regulation of vascular endothelial growth factor production Source: MGI
- regulation of triglyceride biosynthetic process Source: UniProtKB
- response to bacterium Source: MGI
- vertebrate eye-specific patterning Source: ARUK-UCL
Keywordsi
Biological process | Complement alternate pathway, Complement pathway, Fatty acid metabolism, Immunity, Inflammatory response, Innate immunity, Lipid metabolism |
Enzyme and pathway databases
Reactomei | R-MMU-173736, Alternative complement activation R-MMU-174577, Activation of C3 and C5 R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-375276, Peptide ligand-binding receptors R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-418594, G alpha (i) signalling events R-MMU-6798695, Neutrophil degranulation R-MMU-8957275, Post-translational protein phosphorylation R-MMU-977606, Regulation of Complement cascade |
Protein family/group databases
MEROPSi | I39.950 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement C3Alternative name(s): HSE-MSF Cleaved into the following 12 chains: Alternative name(s): C3adesArg |
Gene namesi | Name:C3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88227, C3 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Other locations
- cell surface Source: MGI
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 2 PublicationsAdd BLAST | 24 | |
ChainiPRO_0000005917 | 25 – 1663 | Complement C3Add BLAST | 1639 | |
ChainiPRO_0000005918 | 25 – 666 | Complement C3 beta chainAdd BLAST | 642 | |
ChainiPRO_0000430431 | 569 – 666 | C3-beta-cBy similarityAdd BLAST | 98 | |
ChainiPRO_0000005919 | 671 – 1663 | Complement C3 alpha chainAdd BLAST | 993 | |
ChainiPRO_0000005920 | 671 – 748 | C3a anaphylatoxinAdd BLAST | 78 | |
ChainiPRO_0000419936 | 671 – 747 | Acylation stimulating proteinAdd BLAST | 77 | |
ChainiPRO_0000005921 | 749 – 1663 | Complement C3b alpha' chainAdd BLAST | 915 | |
ChainiPRO_0000005922 | 749 – 954 | Complement C3c alpha' chain fragment 1Add BLAST | 206 | |
ChainiPRO_0000005923 | 955 – 1303 | Complement C3dg fragmentAdd BLAST | 349 | |
ChainiPRO_0000005924 | 955 – 1001 | Complement C3g fragmentAdd BLAST | 47 | |
ChainiPRO_0000005925 | 1002 – 1303 | Complement C3d fragmentAdd BLAST | 302 | |
PeptideiPRO_0000005927 | 1304 – 1320 | Complement C3f fragmentAdd BLAST | 17 | |
ChainiPRO_0000273949 | 1321 – 1663 | Complement C3c alpha' chain fragment 2Add BLAST | 343 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 40 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 559 ↔ 816 | Interchain (between beta and alpha chains)PROSITE-ProRule annotation | ||
Disulfide bondi | 626 ↔ 661 | By similarity | ||
Modified residuei | 671 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 693 ↔ 720 | By similarity | ||
Disulfide bondi | 694 ↔ 727 | By similarity | ||
Disulfide bondi | 707 ↔ 728 | By similarity | ||
Disulfide bondi | 873 ↔ 1513 | By similarity | ||
Glycosylationi | 939 | N-linked (GlcNAc...) asparagine | 1 | |
Modified residuei | 968 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1010 ↔ 1013 | Isoglutamyl cysteine thioester (Cys-Gln)By similarity | ||
Disulfide bondi | 1101 ↔ 1158 | By similarity | ||
Modified residuei | 1321 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 1358 ↔ 1489 | By similarity | ||
Disulfide bondi | 1389 ↔ 1458 | By similarity | ||
Disulfide bondi | 1506 ↔ 1511 | By similarity | ||
Disulfide bondi | 1518 ↔ 1590 | By similarity | ||
Disulfide bondi | 1537 ↔ 1661 | By similarity | ||
Modified residuei | 1573 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 1617 | N-linked (GlcNAc...) asparagine | 1 | |
Disulfide bondi | 1637 ↔ 1646 | By similarity |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 747 – 748 | Cleavage; by carboxypeptidasesBy similarity | 2 | |
Sitei | 748 – 749 | Cleavage; by C3 convertase | 2 | |
Sitei | 954 – 955 | Cleavage; by factor ISequence analysis | 2 | |
Sitei | 1303 – 1304 | Cleavage; by factor I | 2 | |
Sitei | 1320 – 1321 | Cleavage; by factor I | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Thioester bondProteomic databases
CPTACi | non-CPTAC-5595 non-CPTAC-5596 |
EPDi | P01027 |
jPOSTi | P01027 |
MaxQBi | P01027 |
PaxDbi | P01027 |
PeptideAtlasi | P01027 |
PRIDEi | P01027 |
PTM databases
GlyGeni | P01027, 2 sites |
iPTMneti | P01027 |
MetOSitei | P01027 |
PhosphoSitePlusi | P01027 |
SwissPalmi | P01027 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024164, Expressed in uterine cervix and 207 other tissues |
ExpressionAtlasi | P01027, baseline and differential |
Genevisiblei | P01027, MM |
Interactioni
Subunit structurei
C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). Forms the pro-C3-convertase enzyme complex by interacting with Complement factor B Bb fragment (Bb), which is then stabilized by binding CFP, allowing the complex to become active (By similarity). The interaction with Bb is dependent on Mg2+ (By similarity). C3b interacts with CR1 (via Sushi 8 and Sushi 9 domains). C3b interacts with CFH. C3d interacts with CFH. C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2.
Interacts with VSIG4.
Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2.
Interacts with S.aureus fib.
Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.
By similarityGO - Molecular functioni
- C5L2 anaphylatoxin chemotactic receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198418, 9 interactors |
ComplexPortali | CPX-5893, Alternative pathway fluid-phase C3 convertase complex C3(H2O)Bb CPX-988, Complement C3b complex |
IntActi | P01027, 7 interactors |
MINTi | P01027 |
STRINGi | 10090.ENSMUSP00000024988 |
Miscellaneous databases
RNActi | P01027, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 693 – 728 | Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1518 – 1661 | NTRPROSITE-ProRule annotationAdd BLAST | 144 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1634 – 1659 | Interaction with CFP/properdinBy similarityAdd BLAST | 26 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1366, Eukaryota |
GeneTreei | ENSGT00940000154063 |
HOGENOMi | CLU_001634_4_0_1 |
InParanoidi | P01027 |
OMAi | QATNTMQ |
OrthoDBi | 23785at2759 |
TreeFami | TF313285 |
Family and domain databases
CDDi | cd00017, ANATO, 1 hit cd03583, NTR_complement_C3, 1 hit |
Gene3Di | 2.40.50.120, 1 hit 2.60.40.10, 2 hits 2.60.40.690, 1 hit |
InterProi | View protein in InterPro IPR009048, A-macroglobulin_rcpt-bd IPR036595, A-macroglobulin_rcpt-bd_sf IPR011625, A2M_N_BRD IPR011626, Alpha-macroglobulin_TED IPR000020, Anaphylatoxin/fibulin IPR018081, Anaphylatoxin_comp_syst IPR001840, Anaphylatoxn_comp_syst_dom IPR041425, C3/4/5_MG1 IPR035711, Complement_C3-like IPR013783, Ig-like_fold IPR001599, Macroglobln_a2 IPR019742, MacrogloblnA2_CS IPR002890, MG2 IPR041555, MG3 IPR040839, MG4 IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035815, NTR_complement_C3 IPR008930, Terpenoid_cyclase/PrenylTrfase IPR008993, TIMP-like_OB-fold |
PANTHERi | PTHR11412:SF81, PTHR11412:SF81, 1 hit |
Pfami | View protein in Pfam PF00207, A2M, 1 hit PF07703, A2M_BRD, 1 hit PF07677, A2M_recep, 1 hit PF01821, ANATO, 1 hit PF17790, MG1, 1 hit PF01835, MG2, 1 hit PF17791, MG3, 1 hit PF17789, MG4, 1 hit PF01759, NTR, 1 hit PF07678, TED_complement, 1 hit |
PRINTSi | PR00004, ANAPHYLATOXN |
SMARTi | View protein in SMART SM01360, A2M, 1 hit SM01359, A2M_N_2, 1 hit SM01361, A2M_recep, 1 hit SM00104, ANATO, 1 hit SM00643, C345C, 1 hit |
SUPFAMi | SSF47686, SSF47686, 1 hit SSF48239, SSF48239, 1 hit SSF49410, SSF49410, 1 hit SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS00477, ALPHA_2_MACROGLOBULIN, 1 hit PS01177, ANAPHYLATOXIN_1, 1 hit PS01178, ANAPHYLATOXIN_2, 1 hit PS50189, NTR, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPASGSQLL VLLLLLASSP LALGIPMYSI ITPNVLRLES EETIVLEAHD
60 70 80 90 100
AQGDIPVTVT VQDFLKRQVL TSEKTVLTGA SGHLRSVSIK IPASKEFNSD
110 120 130 140 150
KEGHKYVTVV ANFGETVVEK AVMVSFQSGY LFIQTDKTIY TPGSTVLYRI
160 170 180 190 200
FTVDNNLLPV GKTVVILIET PDGIPVKRDI LSSNNQHGIL PLSWNIPELV
210 220 230 240 250
NMGQWKIRAF YEHAPKQIFS AEFEVKEYVL PSFEVRVEPT ETFYYIDDPN
260 270 280 290 300
GLEVSIIAKF LYGKNVDGTA FVIFGVQDGD KKISLAHSLT RVVIEDGVGD
310 320 330 340 350
AVLTRKVLME GVRPSNADAL VGKSLYVSVT VILHSGSDMV EAERSGIPIV
360 370 380 390 400
TSPYQIHFTK TPKFFKPAMP FDLMVFVTNP DGSPASKVLV VTQGSNAKAL
410 420 430 440 450
TQDDGVAKLS INTPNSRQPL TITVRTKKDT LPESRQATKT MEAHPYSTMH
460 470 480 490 500
NSNNYLHLSV SRMELKPGDN LNVNFHLRTD PGHEAKIRYY TYLVMNKGKL
510 520 530 540 550
LKAGRQVREP GQDLVVLSLP ITPEFIPSFR LVAYYTLIGA SGQREVVADS
560 570 580 590 600
VWVDVKDSCI GTLVVKGDPR DNHLAPGQQT TLRIEGNQGA RVGLVAVDKG
610 620 630 640 650
VFVLNKKNKL TQSKIWDVVE KADIGCTPGS GKNYAGVFMD AGLAFKTSQG
660 670 680 690 700
LQTEQRADLE CTKPAARRRR SVQLMERRMD KAGQYTDKGL RKCCEDGMRD
710 720 730 740 750
IPMRYSCQRR ARLITQGENC IKAFIDCCNH ITKLREQHRR DHVLGLARSE
760 770 780 790 800
LEEDIIPEED IISRSHFPQS WLWTIEELKE PEKNGISTKV MNIFLKDSIT
810 820 830 840 850
TWEILAVSLS DKKGICVADP YEIRVMQDFF IDLRLPYSVV RNEQVEIRAV
860 870 880 890 900
LFNYREQEEL KVRVELLHNP AFCSMATAKN RYFQTIKIPP KSSVAVPYVI
910 920 930 940 950
VPLKIGQQEV EVKAAVFNHF ISDGVKKTLK VVPEGMRINK TVAIHTLDPE
960 970 980 990 1000
KLGQGGVQKV DVPAADLSDQ VPDTDSETRI ILQGSPVVQM AEDAVDGERL
1010 1020 1030 1040 1050
KHLIVTPAGC GEQNMIGMTP TVIAVHYLDQ TEQWEKFGIE KRQEALELIK
1060 1070 1080 1090 1100
KGYTQQLAFK QPSSAYAAFN NRPPSTWLTA YVVKVFSLAA NLIAIDSHVL
1110 1120 1130 1140 1150
CGAVKWLILE KQKPDGVFQE DGPVIHQEMI GGFRNAKEAD VSLTAFVLIA
1160 1170 1180 1190 1200
LQEARDICEG QVNSLPGSIN KAGEYIEASY MNLQRPYTVA IAGYALALMN
1210 1220 1230 1240 1250
KLEEPYLGKF LNTAKDRNRW EEPDQQLYNV EATSYALLAL LLLKDFDSVP
1260 1270 1280 1290 1300
PVVRWLNEQR YYGGGYGSTQ ATFMVFQALA QYQTDVPDHK DLNMDVSFHL
1310 1320 1330 1340 1350
PSRSSATTFR LLWENGNLLR SEETKQNEAF SLTAKGKGRG TLSVVAVYHA
1360 1370 1380 1390 1400
KLKSKVTCKK FDLRVSIRPA PETAKKPEEA KNTMFLEICT KYLGDVDATM
1410 1420 1430 1440 1450
SILDISMMTG FAPDTKDLEL LASGVDRYIS KYEMNKAFSN KNTLIIYLEK
1460 1470 1480 1490 1500
ISHTEEDCLT FKVHQYFNVG LIQPGSVKVY SYYNLEESCT RFYHPEKDDG
1510 1520 1530 1540 1550
MLSKLCHSEM CRCAEENCFM QQSQEKINLN VRLDKACEPG VDYVYKTELT
1560 1570 1580 1590 1600
NIELLDDFDE YTMTIQQVIK SGSDEVQAGQ QRKFISHIKC RNALKLQKGK
1610 1620 1630 1640 1650
KYLMWGLSSD LWGEKPNTSY IIGKDTWVEH WPEAEECQDQ KYQKQCEELG
1660
AFTESMVVYG CPN
The sequence of this isoform differs from the canonical sequence as follows:
1-1128: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BKW9 | H3BKW9_MOUSE | Complement C3 | C3 | 185 | Annotation score: | ||
H3BL60 | H3BL60_MOUSE | Complement C3 | C3 | 102 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 137 | K → Q in AAA37339 (PubMed:6356427).Curated | 1 | |
Sequence conflicti | 858 | E → Q in AAC42013 (PubMed:6208565).Curated | 1 | |
Sequence conflicti | 1553 | E → K in AAC42013 (PubMed:6208565).Curated | 1 | |
Sequence conflicti | 1553 | E → K in AAA37336 (PubMed:6094532).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018708 | 1 – 1128 | Missing in isoform Short. CuratedAdd BLAST | 1128 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02782 mRNA Translation: AAC42013.1 BC043338 mRNA Translation: AAH43338.1 M35659 mRNA Translation: AAA37339.1 M33032 mRNA Translation: AAA37378.1 J00369, J00367 Genomic DNA Translation: AAA37336.1 Z37998 Genomic DNA Translation: CAA86099.2 |
CCDSi | CCDS37670.1 [P01027-1] |
PIRi | A92459, C3MS I48284 |
RefSeqi | NP_033908.2, NM_009778.3 [P01027-1] |
Genome annotation databases
Ensembli | ENSMUST00000024988; ENSMUSP00000024988; ENSMUSG00000024164 [P01027-1] |
GeneIDi | 12266 |
KEGGi | mmu:12266 |
UCSCi | uc008deg.2, mouse [P01027-1] |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02782 mRNA Translation: AAC42013.1 BC043338 mRNA Translation: AAH43338.1 M35659 mRNA Translation: AAA37339.1 M33032 mRNA Translation: AAA37378.1 J00369, J00367 Genomic DNA Translation: AAA37336.1 Z37998 Genomic DNA Translation: CAA86099.2 |
CCDSi | CCDS37670.1 [P01027-1] |
PIRi | A92459, C3MS I48284 |
RefSeqi | NP_033908.2, NM_009778.3 [P01027-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6XZU | X-ray | 1.50 | B | 1517-1663 | [»] | |
SMRi | P01027 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198418, 9 interactors |
ComplexPortali | CPX-5893, Alternative pathway fluid-phase C3 convertase complex C3(H2O)Bb CPX-988, Complement C3b complex |
IntActi | P01027, 7 interactors |
MINTi | P01027 |
STRINGi | 10090.ENSMUSP00000024988 |
Protein family/group databases
MEROPSi | I39.950 |
PTM databases
GlyGeni | P01027, 2 sites |
iPTMneti | P01027 |
MetOSitei | P01027 |
PhosphoSitePlusi | P01027 |
SwissPalmi | P01027 |
Proteomic databases
CPTACi | non-CPTAC-5595 non-CPTAC-5596 |
EPDi | P01027 |
jPOSTi | P01027 |
MaxQBi | P01027 |
PaxDbi | P01027 |
PeptideAtlasi | P01027 |
PRIDEi | P01027 |
Protocols and materials databases
ABCDi | P01027, 3 sequenced antibodies |
Antibodypediai | 692, 1768 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000024988; ENSMUSP00000024988; ENSMUSG00000024164 [P01027-1] |
GeneIDi | 12266 |
KEGGi | mmu:12266 |
UCSCi | uc008deg.2, mouse [P01027-1] |
Organism-specific databases
CTDi | 718 |
MGIi | MGI:88227, C3 |
Phylogenomic databases
eggNOGi | KOG1366, Eukaryota |
GeneTreei | ENSGT00940000154063 |
HOGENOMi | CLU_001634_4_0_1 |
InParanoidi | P01027 |
OMAi | QATNTMQ |
OrthoDBi | 23785at2759 |
TreeFami | TF313285 |
Enzyme and pathway databases
Reactomei | R-MMU-173736, Alternative complement activation R-MMU-174577, Activation of C3 and C5 R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-375276, Peptide ligand-binding receptors R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-418594, G alpha (i) signalling events R-MMU-6798695, Neutrophil degranulation R-MMU-8957275, Post-translational protein phosphorylation R-MMU-977606, Regulation of Complement cascade |
Miscellaneous databases
BioGRID-ORCSi | 12266, 1 hit in 14 CRISPR screens |
ChiTaRSi | C3, mouse |
PROi | PR:P01027 |
RNActi | P01027, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024164, Expressed in uterine cervix and 207 other tissues |
ExpressionAtlasi | P01027, baseline and differential |
Genevisiblei | P01027, MM |
Family and domain databases
CDDi | cd00017, ANATO, 1 hit cd03583, NTR_complement_C3, 1 hit |
Gene3Di | 2.40.50.120, 1 hit 2.60.40.10, 2 hits 2.60.40.690, 1 hit |
InterProi | View protein in InterPro IPR009048, A-macroglobulin_rcpt-bd IPR036595, A-macroglobulin_rcpt-bd_sf IPR011625, A2M_N_BRD IPR011626, Alpha-macroglobulin_TED IPR000020, Anaphylatoxin/fibulin IPR018081, Anaphylatoxin_comp_syst IPR001840, Anaphylatoxn_comp_syst_dom IPR041425, C3/4/5_MG1 IPR035711, Complement_C3-like IPR013783, Ig-like_fold IPR001599, Macroglobln_a2 IPR019742, MacrogloblnA2_CS IPR002890, MG2 IPR041555, MG3 IPR040839, MG4 IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR035815, NTR_complement_C3 IPR008930, Terpenoid_cyclase/PrenylTrfase IPR008993, TIMP-like_OB-fold |
PANTHERi | PTHR11412:SF81, PTHR11412:SF81, 1 hit |
Pfami | View protein in Pfam PF00207, A2M, 1 hit PF07703, A2M_BRD, 1 hit PF07677, A2M_recep, 1 hit PF01821, ANATO, 1 hit PF17790, MG1, 1 hit PF01835, MG2, 1 hit PF17791, MG3, 1 hit PF17789, MG4, 1 hit PF01759, NTR, 1 hit PF07678, TED_complement, 1 hit |
PRINTSi | PR00004, ANAPHYLATOXN |
SMARTi | View protein in SMART SM01360, A2M, 1 hit SM01359, A2M_N_2, 1 hit SM01361, A2M_recep, 1 hit SM00104, ANATO, 1 hit SM00643, C345C, 1 hit |
SUPFAMi | SSF47686, SSF47686, 1 hit SSF48239, SSF48239, 1 hit SSF49410, SSF49410, 1 hit SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS00477, ALPHA_2_MACROGLOBULIN, 1 hit PS01177, ANAPHYLATOXIN_1, 1 hit PS01178, ANAPHYLATOXIN_2, 1 hit PS50189, NTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CO3_MOUSE | |
Accessioni | P01027Primary (citable) accession number: P01027 Secondary accession number(s): Q61370, Q80XP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references