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Protein

Alpha-2-macroglobulin

Gene

A2M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase
  • enzyme binding Source: UniProtKB
  • growth factor binding Source: UniProtKB
  • GTPase activator activity Source: Reactome
  • interleukin-1 binding Source: UniProtKB
  • interleukin-8 binding Source: UniProtKB
  • protease binding Source: BHF-UCL
  • serine-type endopeptidase inhibitor activity Source: UniProtKB
  • signaling receptor binding Source: AgBase
  • tumor necrosis factor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-194840 Rho GTPase cycle
R-HSA-8963896 HDL assembly

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.001

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P01023 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2-macroglobulin
Short name:
Alpha-2-M
Alternative name(s):
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:A2M
Synonyms:CPAMD5
ORF Names:FWP007
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175899.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7 A2M

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
103950 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01023

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2

MalaCards human disease database

More...
MalaCardsi
A2M

Open Targets

More...
OpenTargetsi
ENSG00000175899

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24357

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00626 Bacitracin
DB00102 Becaplermin
DB08888 Ocriplasmin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
A2M

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153640

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000005524 – 1474Alpha-2-macroglobulin1 PublicationAdd BLAST1451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 861 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi70N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi247N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi251 ↔ 2991 Publication
Disulfide bondi269 ↔ 2871 Publication
Disulfide bondi278Interchain (with C-431)1 Publication
Glycosylationi396N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi410N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi431Interchain (with C-278)1 Publication
Disulfide bondi470 ↔ 5631 Publication
Disulfide bondi595 ↔ 7712 Publications
Disulfide bondi642 ↔ 6891 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki693Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins)Sequence analysis
Cross-linki694Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins)Sequence analysis
Disulfide bondi821 ↔ 8491 Publication
Disulfide bondi847 ↔ 8831 Publication
Glycosylationi869N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi921 ↔ 13211 Publication
Cross-linki972 ↔ 975Isoglutamyl cysteine thioester (Cys-Gln)1 Publication
Glycosylationi991N-linked (GlcNAc...) asparagine4 Publications1
Disulfide bondi1079 ↔ 11271 Publication
Disulfide bondi1352 ↔ 14671 Publication
Glycosylationi1424N-linked (GlcNAc...) (complex) asparagine4 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Thioester bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P01023

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P01023

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P01023

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01023

PeptideAtlas

More...
PeptideAtlasi
P01023

PRoteomics IDEntifications database

More...
PRIDEi
P01023

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51307

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P01023

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P01023

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P01023

GlyConnect protein glycosylation platform

More...
GlyConnecti
730

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01023

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01023

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Secreted in plasma.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Unlike the rat protein, which is an acute phase protein, this protein is always in circulation at high levels.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175899 Expressed in 235 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_A2M

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01023 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01023 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017621
HPA002265

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; disulfide-linked.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106524, 109 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P01023

Database of interacting proteins

More...
DIPi
DIP-1118N

Protein interaction database and analysis system

More...
IntActi
P01023, 106 interactors

Molecular INTeraction database

More...
MINTi
P01023

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323929

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11474
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BV8NMR-A1337-1474[»]
2P9RX-ray2.30A/B126-227[»]
4ACQX-ray4.30A/B/C/D24-1474[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01023

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01023

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01023

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni690 – 728Bait regionAdd BLAST39
Regioni704 – 709Inhibitory6
Regioni719 – 723Inhibitory5
Regioni730 – 735Inhibitory6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366 Eukaryota
ENOG410XRED LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154904

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000039

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01023

KEGG Orthology (KO)

More...
KOi
K03910

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKIFQMK

Database of Orthologous Groups

More...
OrthoDBi
100680at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01023

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR010916 TonB_box_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF07678 TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P01023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKNKLLHPS LVLLLLVLLP TDASVSGKPQ YMVLVPSLLH TETTEKGCVL
60 70 80 90 100
LSYLNETVTV SASLESVRGN RSLFTDLEAE NDVLHCVAFA VPKSSSNEEV
110 120 130 140 150
MFLTVQVKGP TQEFKKRTTV MVKNEDSLVF VQTDKSIYKP GQTVKFRVVS
160 170 180 190 200
MDENFHPLNE LIPLVYIQDP KGNRIAQWQS FQLEGGLKQF SFPLSSEPFQ
210 220 230 240 250
GSYKVVVQKK SGGRTEHPFT VEEFVLPKFE VQVTVPKIIT ILEEEMNVSV
260 270 280 290 300
CGLYTYGKPV PGHVTVSICR KYSDASDCHG EDSQAFCEKF SGQLNSHGCF
310 320 330 340 350
YQQVKTKVFQ LKRKEYEMKL HTEAQIQEEG TVVELTGRQS SEITRTITKL
360 370 380 390 400
SFVKVDSHFR QGIPFFGQVR LVDGKGVPIP NKVIFIRGNE ANYYSNATTD
410 420 430 440 450
EHGLVQFSIN TTNVMGTSLT VRVNYKDRSP CYGYQWVSEE HEEAHHTAYL
460 470 480 490 500
VFSPSKSFVH LEPMSHELPC GHTQTVQAHY ILNGGTLLGL KKLSFYYLIM
510 520 530 540 550
AKGGIVRTGT HGLLVKQEDM KGHFSISIPV KSDIAPVARL LIYAVLPTGD
560 570 580 590 600
VIGDSAKYDV ENCLANKVDL SFSPSQSLPA SHAHLRVTAA PQSVCALRAV
610 620 630 640 650
DQSVLLMKPD AELSASSVYN LLPEKDLTGF PGPLNDQDNE DCINRHNVYI
660 670 680 690 700
NGITYTPVSS TNEKDMYSFL EDMGLKAFTN SKIRKPKMCP QLQQYEMHGP
710 720 730 740 750
EGLRVGFYES DVMGRGHARL VHVEEPHTET VRKYFPETWI WDLVVVNSAG
760 770 780 790 800
VAEVGVTVPD TITEWKAGAF CLSEDAGLGI SSTASLRAFQ PFFVELTMPY
810 820 830 840 850
SVIRGEAFTL KATVLNYLPK CIRVSVQLEA SPAFLAVPVE KEQAPHCICA
860 870 880 890 900
NGRQTVSWAV TPKSLGNVNF TVSAEALESQ ELCGTEVPSV PEHGRKDTVI
910 920 930 940 950
KPLLVEPEGL EKETTFNSLL CPSGGEVSEE LSLKLPPNVV EESARASVSV
960 970 980 990 1000
LGDILGSAMQ NTQNLLQMPY GCGEQNMVLF APNIYVLDYL NETQQLTPEI
1010 1020 1030 1040 1050
KSKAIGYLNT GYQRQLNYKH YDGSYSTFGE RYGRNQGNTW LTAFVLKTFA
1060 1070 1080 1090 1100
QARAYIFIDE AHITQALIWL SQRQKDNGCF RSSGSLLNNA IKGGVEDEVT
1110 1120 1130 1140 1150
LSAYITIALL EIPLTVTHPV VRNALFCLES AWKTAQEGDH GSHVYTKALL
1160 1170 1180 1190 1200
AYAFALAGNQ DKRKEVLKSL NEEAVKKDNS VHWERPQKPK APVGHFYEPQ
1210 1220 1230 1240 1250
APSAEVEMTS YVLLAYLTAQ PAPTSEDLTS ATNIVKWITK QQNAQGGFSS
1260 1270 1280 1290 1300
TQDTVVALHA LSKYGAATFT RTGKAAQVTI QSSGTFSSKF QVDNNNRLLL
1310 1320 1330 1340 1350
QQVSLPELPG EYSMKVTGEG CVYLQTSLKY NILPEKEEFP FALGVQTLPQ
1360 1370 1380 1390 1400
TCDEPKAHTS FQISLSVSYT GSRSASNMAI VDVKMVSGFI PLKPTVKMLE
1410 1420 1430 1440 1450
RSNHVSRTEV SSNHVLIYLD KVSNQTLSLF FTVLQDVPVR DLKPAIVKVY
1460 1470
DYYETDEFAI AEYNAPCSKD LGNA
Length:1,474
Mass (Da):163,291
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A46DF09EFD3CF40
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W7L3F8W7L3_HUMAN
Alpha-2-macroglobulin
A2M
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1E8F5H1E8_HUMAN
Alpha-2-macroglobulin
A2M
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFH1H0YFH1_HUMAN
Alpha-2-macroglobulin
A2M
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAT02228 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD92851 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63Missing AA sequence (PubMed:6203908).Curated1
Sequence conflicti82D → V in AAT02228 (Ref. 3) Curated1
Sequence conflicti350 – 353LSFV → ACCS in AAH26246 (PubMed:15489334).Curated4
Sequence conflicti563C → E AA sequence (PubMed:6203908).Curated1
Sequence conflicti844A → V in BAD92851 (PubMed:17974005).Curated1
Sequence conflicti872V → M in CAH18188 (PubMed:16541075).Curated1
Sequence conflicti1148A → D in AAA51552 (PubMed:2408344).Curated1
Sequence conflicti1195H → D in AAA51552 (PubMed:2408344).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026820639N → D5 PublicationsCorresponds to variant dbSNP:rs226405Ensembl.1
Natural variantiVAR_000012704R → H. Corresponds to variant dbSNP:rs1800434EnsemblClinVar.1
Natural variantiVAR_026821815L → Q. Corresponds to variant dbSNP:rs3180392Ensembl.1
Natural variantiVAR_000013972C → Y Probably interferes with the activity. 1 PublicationCorresponds to variant dbSNP:rs1800433EnsemblClinVar.1
Natural variantiVAR_0000141000I → V5 PublicationsCorresponds to variant dbSNP:rs669EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M11313 mRNA Translation: AAA51551.1
AY591530 mRNA Translation: AAT02228.1 Different initiation.
AB209614 mRNA Translation: BAD92851.1 Different initiation.
CR749334 mRNA Translation: CAH18188.1
AC007436 Genomic DNA No translation available.
BC026246 mRNA Translation: AAH26246.1
BC040071 mRNA Translation: AAH40071.1
Z11711 Genomic DNA Translation: CAA77774.1
X68728, X68729 Genomic DNA Translation: CAA48670.1
M36501 mRNA Translation: AAA51552.1
AF109189 mRNA Translation: AAQ13498.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44827.1

Protein sequence database of the Protein Information Resource

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PIRi
A94033 MAHU

NCBI Reference Sequences

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RefSeqi
NP_000005.2, NM_000014.5
NP_001334352.1, NM_001347423.1
NP_001334353.1, NM_001347424.1
NP_001334354.1, NM_001347425.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.212838
Hs.88556

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000318602; ENSP00000323929; ENSG00000175899

Database of genes from NCBI RefSeq genomes

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GeneIDi
2

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2

UCSC genome browser

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UCSCi
uc001qvk.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Alpha-2 macroglobulin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11313 mRNA Translation: AAA51551.1
AY591530 mRNA Translation: AAT02228.1 Different initiation.
AB209614 mRNA Translation: BAD92851.1 Different initiation.
CR749334 mRNA Translation: CAH18188.1
AC007436 Genomic DNA No translation available.
BC026246 mRNA Translation: AAH26246.1
BC040071 mRNA Translation: AAH40071.1
Z11711 Genomic DNA Translation: CAA77774.1
X68728, X68729 Genomic DNA Translation: CAA48670.1
M36501 mRNA Translation: AAA51552.1
AF109189 mRNA Translation: AAQ13498.1
CCDSiCCDS44827.1
PIRiA94033 MAHU
RefSeqiNP_000005.2, NM_000014.5
NP_001334352.1, NM_001347423.1
NP_001334353.1, NM_001347424.1
NP_001334354.1, NM_001347425.1
UniGeneiHs.212838
Hs.88556

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BV8NMR-A1337-1474[»]
2P9RX-ray2.30A/B126-227[»]
4ACQX-ray4.30A/B/C/D24-1474[»]
ProteinModelPortaliP01023
SMRiP01023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106524, 109 interactors
CORUMiP01023
DIPiDIP-1118N
IntActiP01023, 106 interactors
MINTiP01023
STRINGi9606.ENSP00000323929

Chemistry databases

DrugBankiDB00626 Bacitracin
DB00102 Becaplermin
DB08888 Ocriplasmin

Protein family/group databases

MEROPSiI39.001
MoonDBiP01023 Predicted

PTM databases

CarbonylDBiP01023
GlyConnecti730
iPTMnetiP01023
PhosphoSitePlusiP01023

Polymorphism and mutation databases

BioMutaiA2M
DMDMi308153640

2D gel databases

DOSAC-COBS-2DPAGEiP01023
SWISS-2DPAGEiP01023

Proteomic databases

EPDiP01023
jPOSTiP01023
MaxQBiP01023
PaxDbiP01023
PeptideAtlasiP01023
PRIDEiP01023
ProteomicsDBi51307

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318602; ENSP00000323929; ENSG00000175899
GeneIDi2
KEGGihsa:2
UCSCiuc001qvk.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2
DisGeNETi2
EuPathDBiHostDB:ENSG00000175899.14

GeneCards: human genes, protein and diseases

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GeneCardsi
A2M

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0026392
HGNCiHGNC:7 A2M
HPAiCAB017621
HPA002265
MalaCardsiA2M
MIMi103950 gene
neXtProtiNX_P01023
OpenTargetsiENSG00000175899
PharmGKBiPA24357

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00940000154904
HOVERGENiHBG000039
InParanoidiP01023
KOiK03910
OMAiTKIFQMK
OrthoDBi100680at2759
PhylomeDBiP01023
TreeFamiTF313285

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-194840 Rho GTPase cycle
R-HSA-8963896 HDL assembly

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
A2M human
EvolutionaryTraceiP01023

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2

Protein Ontology

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PROi
PR:P01023

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175899 Expressed in 235 organ(s), highest expression level in lung
CleanExiHS_A2M
ExpressionAtlasiP01023 baseline and differential
GenevisibleiP01023 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR010916 TonB_box_CS
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF07678 TED_complement, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2MG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01023
Secondary accession number(s): Q13677
, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 5, 2010
Last modified: January 16, 2019
This is version 214 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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