AGT

Functionⁱ

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.

Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.

Angiotensin-3: stimulates aldosterone release.

Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.By similarity3 Publications

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

GO - Molecular functionⁱ

growth factor activity
Source: BHF-UCL
Traceable author statementⁱ
- 10406457
hormone activity Source: BHF-UCL
receptor ligand activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 24296617
serine-type endopeptidase inhibitor activity
Source: ProtInc
Traceable author statementⁱ
- 3397061
sodium channel regulator activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15803439
- 17703433
superoxide-generating NADPH oxidase activator activity
Source: BHF-UCL
Traceable author statementⁱ
- 19193863
type 1 angiotensin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 1378723
type 2 angiotensin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10406457

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of phospholipase C activity Source: Ensembl
aging Source: Ensembl
angiotensin-activated signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 24296617
angiotensin-mediated drinking behavior Source: Ensembl
artery smooth muscle contraction Source: Ensembl
associative learning Source: Ensembl
blood vessel remodeling
Source: BHF-UCL
Traceable author statementⁱ
- 10406457
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 8513325
cell growth involved in cardiac muscle cell development Source: Ensembl
cell surface receptor signaling pathway Source: Ensembl
cellular response to angiotensin Source: Ensembl
cellular response to mechanical stimulus Source: Ensembl
cellular sodium ion homeostasis Source: Ensembl
cytokine secretion Source: Ensembl
ERK1 and ERK2 cascade Source: Ensembl
female pregnancy Source: Ensembl
fibroblast proliferation Source: Ensembl
G-protein coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10406457
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
Source: BHF-UCL
Traceable author statementⁱ
- 17159080
kidney development
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16116425
low-density lipoprotein particle remodeling
Source: BHF-UCL
Non-traceable author statementⁱ
- 17069818
negative regulation of angiogenesis Source: Ensembl
negative regulation of cell growth Source: Ensembl
negative regulation of gene expression
Source: BHF-UCL
Inferred from direct assayⁱ
- 24296617
negative regulation of neurotrophin TRK receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10406457
negative regulation of sodium ion transmembrane transporter activity
Source: BHF-UCL
Traceable author statementⁱ
- 19193863
negative regulation of tissue remodeling Source: Ensembl
nitric oxide mediated signal transduction
Source: BHF-UCL
Traceable author statementⁱ
- 17159080
operant conditioning Source: Ensembl
phospholipase C-activating G-protein coupled receptor signaling pathway
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
positive regulation of activation of Janus kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15153556
positive regulation of blood pressure Source: Ensembl
positive regulation of branching involved in ureteric bud morphogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 18607644
positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
positive regulation of cellular protein metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18971559
positive regulation of cholesterol esterification
Source: BHF-UCL
Inferred from direct assayⁱ
- 18971559
positive regulation of cytokine production
Source: BHF-UCL
Traceable author statementⁱ
- 17906677
positive regulation of cytosolic calcium ion concentration Source: Ensembl
positive regulation of endothelial cell migration
Source: BHF-UCL
Inferred from direct assayⁱ
- 15652490
positive regulation of epidermal growth factor receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 15652490
positive regulation of extracellular matrix constituent secretion Source: Ensembl
positive regulation of extrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10406457
positive regulation of fibroblast proliferation Source: BHF-UCL
positive regulation of gap junction assembly
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 17416596
positive regulation of glucose import in response to insulin stimulus Source: Ensembl
positive regulation of inflammatory response
Source: BHF-UCL
Traceable author statementⁱ
- 17159080
- 17906677
positive regulation of L-arginine import across plasma membrane Source: Ensembl
positive regulation of L-lysine import across plasma membrane Source: Ensembl
positive regulation of macrophage derived foam cell differentiation
Source: BHF-UCL
Inferred by curatorⁱ
- 18971559
positive regulation of membrane hyperpolarization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15803439
- 17703433
positive regulation of NAD(P)H oxidase activity
Source: BHF-UCL
Traceable author statementⁱ
- 17159080
- 19193863
positive regulation of neuron projection development Source: Ensembl
positive regulation of NF-kappaB transcription factor activity
Source: BHF-UCL
Traceable author statementⁱ
- 17906677
positive regulation of nitric oxide biosynthetic process Source: Ensembl
positive regulation of peptidyl-tyrosine phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 15652490
positive regulation of phosphatidylinositol 3-kinase signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 15652490
positive regulation of protein tyrosine kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15153556
positive regulation of reactive oxygen species metabolic process
Source: BHF-UCL
Traceable author statementⁱ
- 17906677
positive regulation of renal sodium excretion Source: Ensembl
positive regulation of superoxide anion generation Source: Ensembl
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 24296617
positive regulation of vascular associated smooth muscle cell migration Source: Ensembl
positive regulation of vascular smooth muscle cell proliferation Source: Ensembl
protein import into nucleus Source: Ensembl
regulation of blood pressure
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 17416596
regulation of blood vessel diameter by renin-angiotensin
Source: BHF-UCL
Traceable author statementⁱ
- 10406457
regulation of blood volume by renin-angiotensin
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
regulation of calcium ion transport Source: Ensembl
regulation of cardiac conduction
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 17416596
regulation of cell growth
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
regulation of cell proliferation
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
regulation of extracellular matrix assembly
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 17416596
regulation of heart rate Source: Ensembl
regulation of lipid metabolic process Source: Reactome
regulation of long-term neuronal synaptic plasticity Source: Ensembl
regulation of norepinephrine secretion Source: Ensembl
regulation of renal output by angiotensin
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
regulation of renal sodium excretion
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
regulation of transmission of nerve impulse Source: Ensembl
regulation of vasoconstriction
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
renal system process
Source: UniProtKB
Inferred from direct assayⁱ
- 21183621
renin-angiotensin regulation of aldosterone production
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
response to estradiol Source: Ensembl
response to muscle activity involved in regulation of muscle adaptation Source: BHF-UCL
smooth muscle cell proliferation Source: Ensembl
stress-activated MAPK cascade Source: Ensembl
uterine smooth muscle contraction Source: Ensembl
vasodilation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Vasoactive, Vasoconstrictor

Molecular function

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P01019

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I04.953

MEROPSⁱ

I04.953

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Angiotensinogen Alternative name(s): Serpin A8 Cleaved into the following 8 chains: Angiotensin-1 Alternative name(s): Angiotensin 1-10 Angiotensin I Short name: Ang I Angiotensin-2 Alternative name(s): Angiotensin 1-8 Angiotensin II Short name: Ang II Angiotensin-3 Alternative name(s): Angiotensin 2-8 Angiotensin III Short name: Ang III Des-Asp[1]-angiotensin II Angiotensin-4 Alternative name(s): Angiotensin 3-8 Angiotensin IV Short name: Ang IV Angiotensin 1-9 Angiotensin 1-7 Angiotensin 1-5 Angiotensin 1-4
Gene namesⁱ	Name:AGT Synonyms:SERPINA8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135744.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:333 AGT
MIMⁱ	106150 gene
neXtProtⁱ	NX_P01019

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Essential hypertension (EHT)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA condition in which blood pressure is consistently higher than normal with no identifiable cause.

Renal tubular dysgenesis (RTD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035433	375	R → Q in RTD. 1 PublicationCorresponds to variant dbSNP:rs74315283EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	183
MalaCards human disease database More...MalaCardsⁱ	AGT
MIMⁱ	145500 phenotype 267430 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000135744
Orphanetⁱ	243761 Essential hypertension 97369 Renal tubular dysgenesis of genetic origin
PharmGKBⁱ	PA42

Chemistry databases

ChEMBLⁱ	CHEMBL3596085
Drug and drug target database More...DrugBankⁱ	DB05206 PS433540

Polymorphism and mutation databases

BioMutaⁱ	AGT
DMDMⁱ	113880

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 33	3 PublicationsAdd BLAST	33
ChainⁱPRO_0000032456	34 – 485	AngiotensinogenAdd BLAST	452
PeptideⁱPRO_0000032457	34 – 43	Angiotensin-1	10
PeptideⁱPRO_0000420659	34 – 42	Angiotensin 1-9	9
PeptideⁱPRO_0000032458	34 – 41	Angiotensin-2	8
PeptideⁱPRO_0000420660	34 – 40	Angiotensin 1-7	7
PeptideⁱPRO_0000420661	34 – 38	Angiotensin 1-5	5
PeptideⁱPRO_0000420662	34 – 37	Angiotensin 1-4	4
PeptideⁱPRO_0000032459	35 – 41	Angiotensin-3	7
PeptideⁱPRO_0000420663	36 – 41	Angiotensin-4	6

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	34	Beta-decarboxylated aspartate; in form angiotensin-A1 Publication	1
Glycosylationⁱ	47	N-linked (GlcNAc...) asparagine3 Publications	1
Disulfide bondⁱ	51 ↔ 171	1 Publication
Glycosylationⁱ	170	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	304	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	328	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).2 Publications

The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P01019
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01019
PaxDbⁱ	P01019
PeptideAtlas More...PeptideAtlasⁱ	P01019
PRIDEⁱ	P01019
ProteomicsDBⁱ	51306

2D gel databases

SWISS-2DPAGEⁱ	P01019

SWISS-2DPAGEⁱ

P01019

PTM databases

CarbonylDBⁱ	P01019
GlyConnectⁱ	703
iPTMnetⁱ	P01019
PhosphoSitePlusⁱ	P01019

Miscellaneous databases

PMAP-CutDBⁱ	P01019

PMAP-CutDBⁱ

P01019

Expressionⁱ

Tissue specificityⁱ

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgeeⁱ	ENSG00000135744 Expressed in 211 organ(s), highest expression level in liver
CleanExⁱ	HS_AGT
ExpressionAtlasⁱ	P01019 baseline and differential
Genevisibleⁱ	P01019 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025798 HPA001557

HPAⁱ

CAB025798
HPA001557

Interactionⁱ

Subunit structureⁱ

During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AGTR1	P30556	2	EBI-6622938,EBI-6623016
Agtr1	P25095	10	EBI-751728,EBI-764979	From Rattus norvegicus.
AGTR2	P50052	2	EBI-2927577,EBI-1748067
Ance	Q10714	2	EBI-751728,EBI-115736	From Drosophila melanogaster.
REN	P00797	2	EBI-751728,EBI-715794

GO - Molecular functionⁱ

growth factor activity
Source: BHF-UCL
Traceable author statementⁱ
- 10406457
hormone activity Source: BHF-UCL
receptor ligand activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 24296617
type 1 angiotensin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 1378723
type 2 angiotensin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10406457

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106690, 15 interactors
CORUMⁱ	P01019
Database of interacting proteins More...DIPⁱ	DIP-309N
IntActⁱ	P01019, 10 interactors
Molecular INTeraction database More...MINTⁱ	P01019
STRINGⁱ	9606.ENSP00000355627

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	42 – 44	Combined sources	3
Turnⁱ	48 – 50	Combined sources	3
Beta strandⁱ	59 – 62	Combined sources	4
Helixⁱ	81 – 93	Combined sources	13
Helixⁱ	97 – 119	Combined sources	23
Beta strandⁱ	122 – 124	Combined sources	3
Turnⁱ	125 – 127	Combined sources	3
Beta strandⁱ	128 – 131	Combined sources	4
Helixⁱ	136 – 148	Combined sources	13
Helixⁱ	152 – 162	Combined sources	11
Beta strandⁱ	167 – 169	Combined sources	3
Turnⁱ	171 – 173	Combined sources	3
Helixⁱ	177 – 192	Combined sources	16
Turnⁱ	195 – 197	Combined sources	3
Beta strandⁱ	203 – 213	Combined sources	11
Helixⁱ	221 – 230	Combined sources	10
Beta strandⁱ	234 – 238	Combined sources	5
Helixⁱ	244 – 259	Combined sources	16
Beta strandⁱ	276 – 287	Combined sources	12
Beta strandⁱ	291 – 293	Combined sources	3
Beta strandⁱ	298 – 300	Combined sources	3
Beta strandⁱ	302 – 305	Combined sources	4
Beta strandⁱ	308 – 310	Combined sources	3
Beta strandⁱ	312 – 324	Combined sources	13
Turnⁱ	325 – 328	Combined sources	4
Beta strandⁱ	329 – 349	Combined sources	21
Helixⁱ	350 – 352	Combined sources	3
Helixⁱ	353 – 360	Combined sources	8
Helixⁱ	363 – 369	Combined sources	7
Beta strandⁱ	373 – 382	Combined sources	10
Beta strandⁱ	385 – 391	Combined sources	7
Helixⁱ	392 – 395	Combined sources	4
Turnⁱ	396 – 400	Combined sources	5
Helixⁱ	401 – 404	Combined sources	4
Beta strandⁱ	407 – 409	Combined sources	3
Turnⁱ	412 – 414	Combined sources	3
Beta strandⁱ	421 – 433	Combined sources	13
Beta strandⁱ	452 – 455	Combined sources	4
Beta strandⁱ	460 – 466	Combined sources	7
Turnⁱ	467 – 470	Combined sources	4
Beta strandⁱ	471 – 479	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P01019
SMRⁱ	P01019
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P01019

EvolutionaryTraceⁱ

P01019

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the serpin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139531
HOVERGENⁱ	HBG004233
InParanoidⁱ	P01019
KEGG Orthology (KO) More...KOⁱ	K09821
OMAⁱ	RFMQAVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G077M
PhylomeDBⁱ	P01019
TreeFamⁱ	TF343201

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02054 angiotensinogen, 1 hit
InterProⁱ	View protein in InterPro IPR000227 Angiotensinogen IPR033834 Angiotensinogen_serpin IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit PTHR11461:SF13 PTHR11461:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
PRINTSⁱ	PR00654 ANGIOTENSNGN
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01019-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST 
        60         70         80         90        100
CEQLAKANAG KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK 
       110        120        130        140        150
LRAAMVGMLA NFLGFRIYGM HSELWGVVHG ATVLSPTAVF GTLASLYLGA 
       160        170        180        190        200
LDHTADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ 
       210        220        230        240        250
AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK 
       260        270        280        290        300
IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF 
       310        320        330        340        350
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA 
       360        370        380        390        400
SDLDKVEGLT FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE 
       410        420        430        440        450
LPAILHTELN LQKLSNDRIR VGEVLNSIFF ELEADEREPT ESTQQLNKPE 
       460        470        480 
VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN PLSTA

Length:485

Mass (Da):53,154

Last modified:July 21, 1986 - v1

Checksum:ⁱ5026C2DFB2DD236E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	51	C → S AA sequence (PubMed:7259779).Curated	1
Sequence conflictⁱ	58	N → D AA sequence (PubMed:7259779).Curated	1
Sequence conflictⁱ	333	Q → E in AAA51679 (PubMed:2924688).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_022933	43	L → F Associated with susceptibility to pre-eclampsia; alters the reactions with renin and angiotensin-converting enzyme. 1 PublicationCorresponds to variant dbSNP:rs41271499Ensembl.	1
Natural variantⁱVAR_029166	98	E → K. Corresponds to variant dbSNP:rs11568032Ensembl.	1
Natural variantⁱVAR_051939	114	G → C. Corresponds to variant dbSNP:rs2229389Ensembl.	1
Natural variantⁱVAR_035431	137	T → M. Corresponds to variant dbSNP:rs34829218Ensembl.	1
Natural variantⁱVAR_007093	207	T → M Associated with hypertension. 1 PublicationCorresponds to variant dbSNP:rs4762EnsemblClinVar.	1
Natural variantⁱVAR_007094	242	T → I Associated with susceptibility to hypertension. 1 PublicationCorresponds to variant dbSNP:rs765678426Ensembl.	1
Natural variantⁱVAR_007095	244	L → R Associated with susceptibility to hypertension. 1 PublicationCorresponds to variant dbSNP:rs5041Ensembl.	1
Natural variantⁱVAR_029167	268	M → I. Corresponds to variant dbSNP:rs11568053Ensembl.	1
Natural variantⁱVAR_007096	268	M → T Associated with essential hypertension and pre-eclampsia. 2 PublicationsCorresponds to variant dbSNP:rs699EnsemblClinVar.	1
Natural variantⁱVAR_007097	281	Y → C Associated with susceptibility to hypertension; alters the structure, glycosylation and secretion of angiotensinogen. 3 PublicationsCorresponds to variant dbSNP:rs56073403Ensembl.	1
Natural variantⁱVAR_035432	335	P → S1 PublicationCorresponds to variant dbSNP:rs17856352Ensembl.	1
Natural variantⁱVAR_035433	375	R → Q in RTD. 1 PublicationCorresponds to variant dbSNP:rs74315283EnsemblClinVar.	1
Natural variantⁱVAR_014573	392	L → M. Corresponds to variant dbSNP:rs1805090Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K02215 mRNA Translation: AAA51731.1 M24689 , M24686, M24687, M24688 Genomic DNA Translation: AAA51679.1 X15324 , X15325, X15326, X15327 Genomic DNA Translation: CAA33385.1 BC011519 mRNA Translation: AAH11519.1 M69110 mRNA Translation: AAA52282.1 S78529 Genomic DNA Translation: AAD14287.1 S78530 Genomic DNA Translation: AAD14288.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1585.1
PIRⁱ	A35203 ANHU
NCBI Reference Sequences More...RefSeqⁱ	NP_000020.1, NM_000029.3
UniGeneⁱ	Hs.19383

Genome annotation databases

Ensemblⁱ	ENST00000366667; ENSP00000355627; ENSG00000135744
GeneIDⁱ	183
KEGGⁱ	hsa:183
UCSC genome browser More...UCSCⁱ	uc001hty.6 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01019	Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8)		HUMAN		485	UniRef100_P01019

Protein	Similar proteins		Species	Score	Length	Source
P01019	Angiotensinogen		GORGO		485	UniRef90_P01019
Angiotensinogen		PANTR		485
Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8)		HUMAN		485
Uncharacterized protein DKFZp469I1012		PONAB		487
Uncharacterized protein		NOMLE		485
+21

Protein	Similar proteins		Species	Score	Length	Source
P01019	Angiotensinogen		PANTR		485	UniRef50_P01019
Angiotensinogen		GORGO		485
Angiotensinogen	)	MOUSE		477
Angiotensinogen	)	RAT		477
Angiotensinogen		CALJA		486
+104

Cross-referencesⁱ

Web resourcesⁱ

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K02215 mRNA Translation: AAA51731.1 M24689 , M24686, M24687, M24688 Genomic DNA Translation: AAA51679.1 X15324 , X15325, X15326, X15327 Genomic DNA Translation: CAA33385.1 BC011519 mRNA Translation: AAH11519.1 M69110 mRNA Translation: AAA52282.1 S78529 Genomic DNA Translation: AAD14287.1 S78530 Genomic DNA Translation: AAD14288.1
CCDSⁱ	CCDS1585.1
PIRⁱ	A35203 ANHU
RefSeqⁱ	NP_000020.1, NM_000029.3
UniGeneⁱ	Hs.19383

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1N9U	NMR	-	A	34-43	[»]
	1N9V	NMR	-	A	34-41	[»]
	2JP8	NMR	-	P	34-40	[»]
	2WXW	X-ray	3.30	A	34-485	[»]
	2X0B	X-ray	4.33	B/D/F/H	34-485	[»]
	3CK0	X-ray	3.00	P	34-41	[»]
	3WOO	X-ray	1.80	C/D	36-41	[»]
	3WOR	X-ray	2.10	C/D	34-41	[»]
	4AA1	X-ray	1.99	P	34-41	[»]
	4APH	X-ray	1.99	P	34-41	[»]
	4FYS	X-ray	2.01	C	36-41	[»]
	5E2Q	X-ray	2.40	B	34-41	[»]
	5M3X	X-ray	2.63	A/B	44-485	[»]
	5M3Y	X-ray	2.30	A	34-485	[»]
ProteinModelPortalⁱ	P01019
SMRⁱ	P01019
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106690, 15 interactors
CORUMⁱ	P01019
DIPⁱ	DIP-309N
IntActⁱ	P01019, 10 interactors
MINTⁱ	P01019
STRINGⁱ	9606.ENSP00000355627

Chemistry databases

ChEMBLⁱ	CHEMBL3596085
DrugBankⁱ	DB05206 PS433540

Protein family/group databases

MEROPSⁱ	I04.953

MEROPSⁱ

I04.953

PTM databases

CarbonylDBⁱ	P01019
GlyConnectⁱ	703
iPTMnetⁱ	P01019
PhosphoSitePlusⁱ	P01019

Polymorphism and mutation databases

BioMutaⁱ	AGT
DMDMⁱ	113880

2D gel databases

SWISS-2DPAGEⁱ	P01019

SWISS-2DPAGEⁱ

P01019

Proteomic databases

EPDⁱ	P01019
MaxQBⁱ	P01019
PaxDbⁱ	P01019
PeptideAtlasⁱ	P01019
PRIDEⁱ	P01019
ProteomicsDBⁱ	51306

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	183
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000366667; ENSP00000355627; ENSG00000135744
GeneIDⁱ	183
KEGGⁱ	hsa:183
UCSCⁱ	uc001hty.6 human

Organism-specific databases

CTDⁱ	183
DisGeNETⁱ	183
EuPathDBⁱ	HostDB:ENSG00000135744.7
GeneCardsⁱ	AGT
HGNCⁱ	HGNC:333 AGT
HPAⁱ	CAB025798 HPA001557
MalaCardsⁱ	AGT
MIMⁱ	106150 gene 145500 phenotype 267430 phenotype
neXtProtⁱ	NX_P01019
OpenTargetsⁱ	ENSG00000135744
Orphanetⁱ	243761 Essential hypertension 97369 Renal tubular dysgenesis of genetic origin
PharmGKBⁱ	PA42
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
GeneTreeⁱ	ENSGT00890000139531
HOVERGENⁱ	HBG004233
InParanoidⁱ	P01019
KOⁱ	K09821
OMAⁱ	RFMQAVT
OrthoDBⁱ	EOG091G077M
PhylomeDBⁱ	P01019
TreeFamⁱ	TF343201

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P01019

Miscellaneous databases

ChiTaRSⁱ	AGT human
EvolutionaryTraceⁱ	P01019
GeneWikiⁱ	Angiotensin
GenomeRNAiⁱ	183
PMAP-CutDBⁱ	P01019
Protein Ontology More...PROⁱ	PR:P01019
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135744 Expressed in 211 organ(s), highest expression level in liver
CleanExⁱ	HS_AGT
ExpressionAtlasⁱ	P01019 baseline and differential
Genevisibleⁱ	P01019 HS

Family and domain databases

CDDⁱ	cd02054 angiotensinogen, 1 hit
InterProⁱ	View protein in InterPro IPR000227 Angiotensinogen IPR033834 Angiotensinogen_serpin IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit PTHR11461:SF13 PTHR11461:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
PRINTSⁱ	PR00654 ANGIOTENSNGN
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANGT_HUMAN
Accessionⁱ	P01019Primary (citable) accession number: P01019 Secondary accession number(s): Q16358, Q16359, Q96F91
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	September 12, 2018
	This is version 218 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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Supporting data

UniProtKB - P01019 (ANGT_HUMAN)

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Angiotensinogen

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ