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Protein

Angiotensinogen

Gene

AGT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
Angiotensin-3: stimulates aldosterone release.
Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.By similarity3 Publications

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • growth factor activity Source: BHF-UCL
  • hormone activity Source: BHF-UCL
  • receptor ligand activity Source: BHF-UCL
  • serine-type endopeptidase inhibitor activity Source: GO_Central
  • sodium channel regulator activity Source: BHF-UCL
  • superoxide-generating NADPH oxidase activator activity Source: BHF-UCL
  • type 1 angiotensin receptor binding Source: BHF-UCL
  • type 2 angiotensin receptor binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

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SIGNORi
P01019

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I04.953

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Angiotensinogen
Alternative name(s):
Serpin A8
Cleaved into the following 8 chains:
Alternative name(s):
Angiotensin 1-10
Angiotensin I
Short name:
Ang I
Alternative name(s):
Angiotensin 1-8
Angiotensin II
Short name:
Ang II
Alternative name(s):
Angiotensin 2-8
Angiotensin III
Short name:
Ang III
Des-Asp[1]-angiotensin II
Alternative name(s):
Angiotensin 3-8
Angiotensin IV
Short name:
Ang IV
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGT
Synonyms:SERPINA8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135744.7

Human Gene Nomenclature Database

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HGNCi
HGNC:333 AGT

Online Mendelian Inheritance in Man (OMIM)

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MIMi
106150 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P01019

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Essential hypertension (EHT)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA condition in which blood pressure is consistently higher than normal with no identifiable cause.
See also OMIM:145500
Renal tubular dysgenesis (RTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
See also OMIM:267430
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035433375R → Q in RTD. 1 PublicationCorresponds to variant dbSNP:rs74315283EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
183

MalaCards human disease database

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MalaCardsi
AGT
MIMi145500 phenotype
267430 phenotype

Open Targets

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OpenTargetsi
ENSG00000135744

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
243761 NON RARE IN EUROPE: Essential hypertension
97369 Renal tubular dysgenesis of genetic origin

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA42

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3596085

Drug and drug target database

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DrugBanki
DB05206 PS433540

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AGT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 333 PublicationsAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003245634 – 485AngiotensinogenAdd BLAST452
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000003245734 – 43Angiotensin-110
PeptideiPRO_000042065934 – 42Angiotensin 1-99
PeptideiPRO_000003245834 – 41Angiotensin-28
PeptideiPRO_000042066034 – 40Angiotensin 1-77
PeptideiPRO_000042066134 – 38Angiotensin 1-55
PeptideiPRO_000042066234 – 37Angiotensin 1-44
PeptideiPRO_000003245935 – 41Angiotensin-37
PeptideiPRO_000042066336 – 41Angiotensin-46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34Beta-decarboxylated aspartate; in form angiotensin-A1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagine3 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 1711 Publication
Glycosylationi170N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi304N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi328N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.1 Publication
In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin).2 Publications
The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P01019

MaxQB - The MaxQuant DataBase

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MaxQBi
P01019

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P01019

PeptideAtlas

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PeptideAtlasi
P01019

PRoteomics IDEntifications database

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PRIDEi
P01019

ProteomicsDB human proteome resource

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ProteomicsDBi
51306

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P01019

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P01019

GlyConnect protein glycosylation platform

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GlyConnecti
703

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P01019

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01019

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01019

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135744 Expressed in 211 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
HS_AGT

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P01019 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P01019 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025798
HPA001557

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106690, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P01019

Database of interacting proteins

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DIPi
DIP-309N

Protein interaction database and analysis system

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IntActi
P01019, 10 interactors

Molecular INTeraction database

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MINTi
P01019

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355627

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1485
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P01019

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01019

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P01019

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2392 Eukaryota
COG4826 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00890000139531

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004233

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01019

KEGG Orthology (KO)

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KOi
K09821

Identification of Orthologs from Complete Genome Data

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OMAi
TYVHFQG

Database of Orthologous Groups

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OrthoDBi
EOG091G077M

Database for complete collections of gene phylogenies

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PhylomeDBi
P01019

TreeFam database of animal gene trees

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TreeFami
TF343201

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02054 angiotensinogen, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000227 Angiotensinogen
IPR033834 Angiotensinogen_serpin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf

The PANTHER Classification System

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PANTHERi
PTHR11461 PTHR11461, 1 hit
PTHR11461:SF13 PTHR11461:SF13, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00079 Serpin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00654 ANGIOTENSNGN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00093 SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56574 SSF56574, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00284 SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01019-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST
60 70 80 90 100
CEQLAKANAG KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK
110 120 130 140 150
LRAAMVGMLA NFLGFRIYGM HSELWGVVHG ATVLSPTAVF GTLASLYLGA
160 170 180 190 200
LDHTADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ
210 220 230 240 250
AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK
260 270 280 290 300
IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF
310 320 330 340 350
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA
360 370 380 390 400
SDLDKVEGLT FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE
410 420 430 440 450
LPAILHTELN LQKLSNDRIR VGEVLNSIFF ELEADEREPT ESTQQLNKPE
460 470 480
VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN PLSTA
Length:485
Mass (Da):53,154
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5026C2DFB2DD236E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51C → S AA sequence (PubMed:7259779).Curated1
Sequence conflicti58N → D AA sequence (PubMed:7259779).Curated1
Sequence conflicti333Q → E in AAA51679 (PubMed:2924688).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02293343L → F Associated with susceptibility to pre-eclampsia; alters the reactions with renin and angiotensin-converting enzyme. 1 PublicationCorresponds to variant dbSNP:rs41271499Ensembl.1
Natural variantiVAR_02916698E → K. Corresponds to variant dbSNP:rs11568032Ensembl.1
Natural variantiVAR_051939114G → C. Corresponds to variant dbSNP:rs2229389Ensembl.1
Natural variantiVAR_035431137T → M. Corresponds to variant dbSNP:rs34829218Ensembl.1
Natural variantiVAR_007093207T → M Associated with hypertension. 1 PublicationCorresponds to variant dbSNP:rs4762EnsemblClinVar.1
Natural variantiVAR_007094242T → I Associated with susceptibility to hypertension. 1 PublicationCorresponds to variant dbSNP:rs765678426Ensembl.1
Natural variantiVAR_007095244L → R Associated with susceptibility to hypertension. 1 PublicationCorresponds to variant dbSNP:rs5041Ensembl.1
Natural variantiVAR_029167268M → I. Corresponds to variant dbSNP:rs11568053Ensembl.1
Natural variantiVAR_007096268M → T Associated with essential hypertension and pre-eclampsia. 2 PublicationsCorresponds to variant dbSNP:rs699EnsemblClinVar.1
Natural variantiVAR_007097281Y → C Associated with susceptibility to hypertension; alters the structure, glycosylation and secretion of angiotensinogen. 3 PublicationsCorresponds to variant dbSNP:rs56073403Ensembl.1
Natural variantiVAR_035432335P → S1 PublicationCorresponds to variant dbSNP:rs17856352Ensembl.1
Natural variantiVAR_035433375R → Q in RTD. 1 PublicationCorresponds to variant dbSNP:rs74315283EnsemblClinVar.1
Natural variantiVAR_014573392L → M. Corresponds to variant dbSNP:rs1805090Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
K02215 mRNA Translation: AAA51731.1
M24689
, M24686, M24687, M24688 Genomic DNA Translation: AAA51679.1
X15324
, X15325, X15326, X15327 Genomic DNA Translation: CAA33385.1
BC011519 mRNA Translation: AAH11519.1
M69110 mRNA Translation: AAA52282.1
S78529 Genomic DNA Translation: AAD14287.1
S78530 Genomic DNA Translation: AAD14288.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1585.1

Protein sequence database of the Protein Information Resource

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PIRi
A35203 ANHU

NCBI Reference Sequences

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RefSeqi
NP_000020.1, NM_000029.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.19383

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000366667; ENSP00000355627; ENSG00000135744

Database of genes from NCBI RefSeq genomes

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GeneIDi
183

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:183

UCSC genome browser

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UCSCi
uc001hty.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02215 mRNA Translation: AAA51731.1
M24689
, M24686, M24687, M24688 Genomic DNA Translation: AAA51679.1
X15324
, X15325, X15326, X15327 Genomic DNA Translation: CAA33385.1
BC011519 mRNA Translation: AAH11519.1
M69110 mRNA Translation: AAA52282.1
S78529 Genomic DNA Translation: AAD14287.1
S78530 Genomic DNA Translation: AAD14288.1
CCDSiCCDS1585.1
PIRiA35203 ANHU
RefSeqiNP_000020.1, NM_000029.3
UniGeneiHs.19383

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N9UNMR-A34-43[»]
1N9VNMR-A34-41[»]
2JP8NMR-P34-40[»]
2WXWX-ray3.30A34-485[»]
2X0BX-ray4.33B/D/F/H34-485[»]
3CK0X-ray3.00P34-41[»]
3WOOX-ray1.80C/D36-41[»]
3WORX-ray2.10C/D34-41[»]
4AA1X-ray1.99P34-41[»]
4APHX-ray1.99P34-41[»]
4FYSX-ray2.01C36-41[»]
5E2QX-ray2.40B34-41[»]
5M3XX-ray2.63A/B44-485[»]
5M3YX-ray2.30A34-485[»]
ProteinModelPortaliP01019
SMRiP01019
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106690, 15 interactors
CORUMiP01019
DIPiDIP-309N
IntActiP01019, 10 interactors
MINTiP01019
STRINGi9606.ENSP00000355627

Chemistry databases

ChEMBLiCHEMBL3596085
DrugBankiDB05206 PS433540

Protein family/group databases

MEROPSiI04.953

PTM databases

CarbonylDBiP01019
GlyConnecti703
iPTMnetiP01019
PhosphoSitePlusiP01019

Polymorphism and mutation databases

BioMutaiAGT
DMDMi113880

2D gel databases

SWISS-2DPAGEiP01019

Proteomic databases

EPDiP01019
MaxQBiP01019
PaxDbiP01019
PeptideAtlasiP01019
PRIDEiP01019
ProteomicsDBi51306

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
183
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366667; ENSP00000355627; ENSG00000135744
GeneIDi183
KEGGihsa:183
UCSCiuc001hty.6 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
183
DisGeNETi183
EuPathDBiHostDB:ENSG00000135744.7

GeneCards: human genes, protein and diseases

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GeneCardsi
AGT
HGNCiHGNC:333 AGT
HPAiCAB025798
HPA001557
MalaCardsiAGT
MIMi106150 gene
145500 phenotype
267430 phenotype
neXtProtiNX_P01019
OpenTargetsiENSG00000135744
Orphaneti243761 NON RARE IN EUROPE: Essential hypertension
97369 Renal tubular dysgenesis of genetic origin
PharmGKBiPA42

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00890000139531
HOVERGENiHBG004233
InParanoidiP01019
KOiK09821
OMAiTYVHFQG
OrthoDBiEOG091G077M
PhylomeDBiP01019
TreeFamiTF343201

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiP01019

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AGT human
EvolutionaryTraceiP01019

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Angiotensin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
183
PMAP-CutDBiP01019

Protein Ontology

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PROi
PR:P01019

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135744 Expressed in 211 organ(s), highest expression level in liver
CleanExiHS_AGT
ExpressionAtlasiP01019 baseline and differential
GenevisibleiP01019 HS

Family and domain databases

CDDicd02054 angiotensinogen, 1 hit
InterProiView protein in InterPro
IPR000227 Angiotensinogen
IPR033834 Angiotensinogen_serpin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF13 PTHR11461:SF13, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00654 ANGIOTENSNGN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANGT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01019
Secondary accession number(s): Q16358, Q16359, Q96F91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 5, 2018
This is version 220 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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