UniProtKB - P01019 (ANGT_HUMAN)
Angiotensinogen
AGT
Functioni
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Binds the DEAR/FBXW7-AS1 receptor (By similarity).
By similarityStimulates aldosterone release.
Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
By similarity3 PublicationsGO - Molecular functioni
- growth factor activity Source: BHF-UCL
- hormone activity Source: BHF-UCL
- receptor ligand activity Source: BHF-UCL
- serine-type endopeptidase inhibitor activity Source: GO_Central
- sodium channel regulator activity Source: BHF-UCL
- superoxide-generating NADPH oxidase activator activity Source: BHF-UCL
- type 1 angiotensin receptor binding Source: BHF-UCL
- type 2 angiotensin receptor binding Source: BHF-UCL
GO - Biological processi
- activation of phospholipase C activity Source: Ensembl
- aging Source: Ensembl
- angiotensin-activated signaling pathway Source: BHF-UCL
- angiotensin-mediated drinking behavior Source: Ensembl
- artery smooth muscle contraction Source: Ensembl
- associative learning Source: Ensembl
- blood vessel remodeling Source: BHF-UCL
- cell-cell signaling Source: ProtInc
- cell growth involved in cardiac muscle cell development Source: Ensembl
- cell surface receptor signaling pathway Source: Ensembl
- cellular response to angiotensin Source: Ensembl
- cellular response to mechanical stimulus Source: Ensembl
- cellular sodium ion homeostasis Source: Ensembl
- ERK1 and ERK2 cascade Source: Ensembl
- female pregnancy Source: Ensembl
- fibroblast proliferation Source: Ensembl
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCL
- kidney development Source: BHF-UCL
- low-density lipoprotein particle remodeling Source: BHF-UCL
- maintenance of blood vessel diameter homeostasis by renin-angiotensin Source: BHF-UCL
- negative regulation of angiogenesis Source: Ensembl
- negative regulation of cell growth Source: Ensembl
- negative regulation of endopeptidase activity Source: GO_Central
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of MAP kinase activity Source: CACAO
- negative regulation of neurotrophin TRK receptor signaling pathway Source: BHF-UCL
- negative regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
- negative regulation of tissue remodeling Source: Ensembl
- nitric oxide mediated signal transduction Source: BHF-UCL
- operant conditioning Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- positive regulation of activation of Janus kinase activity Source: UniProtKB
- positive regulation of blood pressure Source: Ensembl
- positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
- positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
- positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
- positive regulation of cellular protein metabolic process Source: BHF-UCL
- positive regulation of cholesterol esterification Source: BHF-UCL
- positive regulation of cytokine production Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of endothelial cell migration Source: BHF-UCL
- positive regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of extracellular matrix constituent secretion Source: Ensembl
- positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
- positive regulation of fibroblast proliferation Source: BHF-UCL
- positive regulation of gap junction assembly Source: BHF-UCL
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of insulin receptor signaling pathway Source: Ensembl
- positive regulation of L-arginine import across plasma membrane Source: Ensembl
- positive regulation of L-lysine import across plasma membrane Source: Ensembl
- positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
- positive regulation of membrane hyperpolarization Source: BHF-UCL
- positive regulation of NAD(P)H oxidase activity Source: BHF-UCL
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of protein tyrosine kinase activity Source: UniProtKB
- positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of superoxide anion generation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- positive regulation of vascular associated smooth muscle cell migration Source: Ensembl
- positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- protein import into nucleus Source: Ensembl
- regulation of apoptotic process Source: GO_Central
- regulation of blood pressure Source: BHF-UCL
- regulation of blood volume by renin-angiotensin Source: BHF-UCL
- regulation of calcium ion transport Source: Ensembl
- regulation of cardiac conduction Source: BHF-UCL
- regulation of cell growth Source: BHF-UCL
- regulation of cell population proliferation Source: BHF-UCL
- regulation of extracellular matrix assembly Source: BHF-UCL
- regulation of heart rate Source: Ensembl
- regulation of long-term neuronal synaptic plasticity Source: Ensembl
- regulation of norepinephrine secretion Source: Ensembl
- regulation of renal output by angiotensin Source: BHF-UCL
- regulation of renal sodium excretion Source: BHF-UCL
- regulation of transmission of nerve impulse Source: Ensembl
- regulation of vasoconstriction Source: BHF-UCL
- renal system process Source: UniProtKB
- renin-angiotensin regulation of aldosterone production Source: BHF-UCL
- response to estradiol Source: Ensembl
- response to muscle activity involved in regulation of muscle adaptation Source: BHF-UCL
- smooth muscle cell proliferation Source: Ensembl
- stress-activated MAPK cascade Source: Ensembl
- uterine smooth muscle contraction Source: Ensembl
- vasodilation Source: Ensembl
Keywordsi
Molecular function | Vasoactive, Vasoconstrictor |
Enzyme and pathway databases
PathwayCommonsi | P01019 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P01019 |
SIGNORi | P01019 |
Protein family/group databases
MEROPSi | I04.953 |
Names & Taxonomyi
Protein namesi | Recommended name: AngiotensinogenAlternative name(s): Serpin A8 Cleaved into the following 8 chains: Alternative name(s): Angiotensin 1-10 Angiotensin I Short name: Ang I Alternative name(s): Angiotensin 1-8 Angiotensin II Short name: Ang II Alternative name(s): Angiotensin 2-8 Angiotensin III Short name: Ang III Des-Asp[1]-angiotensin II Alternative name(s): Angiotensin 3-8 Angiotensin IV Short name: Ang IV |
Gene namesi | Name:AGT Synonyms:SERPINA8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:333, AGT |
MIMi | 106150, gene |
neXtProti | NX_P01019 |
VEuPathDBi | HostDB:ENSG00000135744 |
Subcellular locationi
Extracellular region or secreted
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: BHF-UCL
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Essential hypertension (EHT)2 Publications
Renal tubular dysgenesis (RTD)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035433 | 366 | R → Q in RTD. 1 PublicationCorresponds to variant dbSNP:rs74315283Ensembl. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 183 |
MalaCardsi | AGT |
MIMi | 145500, phenotype 267430, phenotype |
Orphaneti | 243761, NON RARE IN EUROPE: Essential hypertension 97369, Renal tubular dysgenesis of genetic origin |
PharmGKBi | PA42 |
Miscellaneous databases
Pharosi | P01019, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3596085 |
DrugBanki | DB09130, Copper DB12548, Sparsentan DB01593, Zinc DB14487, Zinc acetate |
Genetic variation databases
BioMutai | AGT |
DMDMi | 113880 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 3 PublicationsAdd BLAST | 24 | |
ChainiPRO_0000032456 | 25 – 476 | AngiotensinogenAdd BLAST | 452 | |
PeptideiPRO_0000032457 | 25 – 34 | Angiotensin-1 | 10 | |
PeptideiPRO_0000420659 | 25 – 33 | Angiotensin 1-9 | 9 | |
PeptideiPRO_0000032458 | 25 – 32 | Angiotensin-2 | 8 | |
PeptideiPRO_0000420660 | 25 – 31 | Angiotensin 1-7 | 7 | |
PeptideiPRO_0000420661 | 25 – 29 | Angiotensin 1-5 | 5 | |
PeptideiPRO_0000420662 | 25 – 28 | Angiotensin 1-4 | 4 | |
PeptideiPRO_0000032459 | 26 – 32 | Angiotensin-3 | 7 | |
PeptideiPRO_0000420663 | 27 – 32 | Angiotensin-4 | 6 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | Beta-decarboxylated aspartate; in form angiotensin-A1 Publication | 1 | |
Glycosylationi | 38 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Disulfide bondi | 42 ↔ 162 | 1 Publication | ||
Glycosylationi | 161 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 295 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 319 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P01019 |
jPOSTi | P01019 |
MassIVEi | P01019 |
MaxQBi | P01019 |
PaxDbi | P01019 |
PeptideAtlasi | P01019 |
PRIDEi | P01019 |
ProteomicsDBi | 51306 |
2D gel databases
SWISS-2DPAGEi | P01019 |
PTM databases
CarbonylDBi | P01019 |
GlyConnecti | 703, 12 N-Linked glycans (3 sites) |
GlyGeni | P01019, 5 sites, 20 N-linked glycans (3 sites), 1 O-linked glycan (1 site) |
iPTMneti | P01019 |
PhosphoSitePlusi | P01019 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000135744, Expressed in liver and 223 other tissues |
ExpressionAtlasi | P01019, baseline and differential |
Genevisiblei | P01019, HS |
Organism-specific databases
HPAi | ENSG00000135744, Tissue enriched (liver) |
Interactioni
Subunit structurei
During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.
2 PublicationsBinary interactionsi
P01019
Angiotensin-1 (PRO_0000032457)
With | #Exp. | IntAct |
---|---|---|
ACE2 [Q9BYF1] | 2 | EBI-25493366,EBI-7730807 |
Angiotensin-2 (PRO_0000032458)
With | #Exp. | IntAct |
---|---|---|
ACE2 [Q9BYF1] | 5 | EBI-6622938,EBI-7730807 |
AGTR1 [P30556] | 2 | EBI-6622938,EBI-6623016 |
Angiotensin-3 (PRO_0000032459)
With | #Exp. | IntAct |
---|---|---|
AGTR2 [P50052] | 2 | EBI-2927577,EBI-1748067 |
GO - Molecular functioni
- growth factor activity Source: BHF-UCL
- hormone activity Source: BHF-UCL
- receptor ligand activity Source: BHF-UCL
- type 1 angiotensin receptor binding Source: BHF-UCL
- type 2 angiotensin receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 106690, 21 interactors |
CORUMi | P01019 |
DIPi | DIP-309N |
IntActi | P01019, 26 interactors |
MINTi | P01019 |
STRINGi | 9606.ENSP00000355627 |
Miscellaneous databases
RNActi | P01019, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P01019 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01019 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
HOGENOMi | CLU_045267_1_0_1 |
InParanoidi | P01019 |
OMAi | WAFTRQD |
OrthoDBi | 450590at2759 |
PhylomeDBi | P01019 |
TreeFami | TF343201 |
Family and domain databases
CDDi | cd02054, serpinA8_AGT, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR000227, Angiotensinogen IPR033834, Angiotensinogen_serpin_dom IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit PTHR11461:SF331, PTHR11461:SF331, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
PRINTSi | PR00654, ANGIOTENSNGN |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAPAGVSLRA TILCLLAWAG LAAGDRVYIH PFHLVIHNES TCEQLAKANA
60 70 80 90 100
GKPKDPTFIP APIQAKTSPV DEKALQDQLV LVAAKLDTED KLRAAMVGML
110 120 130 140 150
ANFLGFRIYG MHSELWGVVH GATVLSPTAV FGTLASLYLG ALDHTADRLQ
160 170 180 190 200
AILGVPWKDK NCTSRLDAHK VLSALQAVQG LLVAQGRADS QAQLLLSTVV
210 220 230 240 250
GVFTAPGLHL KQPFVQGLAL YTPVVLPRSL DFTELDVAAE KIDRFMQAVT
260 270 280 290 300
GWKTGCSLMG ASVDSTLAFN TYVHFQGKMK GFSLLAEPQE FWVDNSTSVS
310 320 330 340 350
VPMLSGMGTF QHWSDIQDNF SVTQVPFTES ACLLLIQPHY ASDLDKVEGL
360 370 380 390 400
TFQQNSLNWM KKLSPRTIHL TMPQLVLQGS YDLQDLLAQA ELPAILHTEL
410 420 430 440 450
NLQKLSNDRI RVGEVLNSIF FELEADEREP TESTQQLNKP EVLEVTLNRP
460 470
FLFAVYDQSA TALHFLGRVA NPLSTA
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A7P0T8D1 | A0A7P0T8D1_HUMAN | Angiotensinogen | AGT | 476 | Annotation score: | ||
A0A7P0TBH1 | A0A7P0TBH1_HUMAN | Angiotensinogen | AGT | 473 | Annotation score: | ||
A0A7P0T9S6 | A0A7P0T9S6_HUMAN | Angiotensinogen | AGT | 366 | Annotation score: | ||
A0A7P0TA52 | A0A7P0TA52_HUMAN | Angiotensinogen | AGT | 420 | Annotation score: | ||
A0A7P0TAP4 | A0A7P0TAP4_HUMAN | Angiotensinogen | AGT | 285 | Annotation score: | ||
A0A7P0Z441 | A0A7P0Z441_HUMAN | Angiotensinogen | AGT | 286 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | C → S AA sequence (PubMed:7259779).Curated | 1 | |
Sequence conflicti | 49 | N → D AA sequence (PubMed:7259779).Curated | 1 | |
Sequence conflicti | 324 | Q → E in AAA51679 (PubMed:2924688).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022933 | 34 | L → F Associated with susceptibility to pre-eclampsia; alters the reactions with renin and angiotensin-converting enzyme. 1 PublicationCorresponds to variant dbSNP:rs41271499Ensembl. | 1 | |
Natural variantiVAR_029166 | 89 | E → K. Corresponds to variant dbSNP:rs11568032Ensembl. | 1 | |
Natural variantiVAR_051939 | 105 | G → C. Corresponds to variant dbSNP:rs2229389Ensembl. | 1 | |
Natural variantiVAR_035431 | 128 | T → M. Corresponds to variant dbSNP:rs34829218Ensembl. | 1 | |
Natural variantiVAR_007093 | 198 | T → M Associated with hypertension. 1 PublicationCorresponds to variant dbSNP:rs4762Ensembl. | 1 | |
Natural variantiVAR_007094 | 233 | T → I Associated with susceptibility to hypertension. 1 PublicationCorresponds to variant dbSNP:rs765678426Ensembl. | 1 | |
Natural variantiVAR_007095 | 235 | L → R Associated with susceptibility to hypertension. 1 PublicationCorresponds to variant dbSNP:rs5041Ensembl. | 1 | |
Natural variantiVAR_029167 | 259 | M → I. Corresponds to variant dbSNP:rs11568053Ensembl. | 1 | |
Natural variantiVAR_007096 | 259 | M → T Associated with essential hypertension and pre-eclampsia. 2 PublicationsCorresponds to variant dbSNP:rs699Ensembl. | 1 | |
Natural variantiVAR_007097 | 272 | Y → C Associated with susceptibility to hypertension; alters the structure, glycosylation and secretion of angiotensinogen. 3 PublicationsCorresponds to variant dbSNP:rs56073403Ensembl. | 1 | |
Natural variantiVAR_035432 | 326 | P → S1 PublicationCorresponds to variant dbSNP:rs17856352Ensembl. | 1 | |
Natural variantiVAR_035433 | 366 | R → Q in RTD. 1 PublicationCorresponds to variant dbSNP:rs74315283Ensembl. | 1 | |
Natural variantiVAR_014573 | 383 | L → M. Corresponds to variant dbSNP:rs1805090Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02215 mRNA Translation: AAA51731.1 Different initiation. M24689 , M24686, M24687, M24688 Genomic DNA Translation: AAA51679.1 Different initiation. X15324 , X15325, X15326, X15327 Genomic DNA Translation: CAA33385.1 Different initiation. BC011519 mRNA Translation: AAH11519.1 Different initiation. M69110 mRNA Translation: AAA52282.1 Different initiation. S78529 Genomic DNA Translation: AAD14287.1 S78530 Genomic DNA Translation: AAD14288.1 |
PIRi | A35203, ANHU |
RefSeqi | NP_000020.1, NM_000029.3 |
Genome annotation databases
Ensembli | ENST00000366667; ENSP00000355627; ENSG00000135744 |
GeneIDi | 183 |
UCSCi | uc001hty.6, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Angiotensin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02215 mRNA Translation: AAA51731.1 Different initiation. M24689 , M24686, M24687, M24688 Genomic DNA Translation: AAA51679.1 Different initiation. X15324 , X15325, X15326, X15327 Genomic DNA Translation: CAA33385.1 Different initiation. BC011519 mRNA Translation: AAH11519.1 Different initiation. M69110 mRNA Translation: AAA52282.1 Different initiation. S78529 Genomic DNA Translation: AAD14287.1 S78530 Genomic DNA Translation: AAD14288.1 |
PIRi | A35203, ANHU |
RefSeqi | NP_000020.1, NM_000029.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N9U | NMR | - | A | 25-34 | [»] | |
1N9V | NMR | - | A | 25-32 | [»] | |
2JP8 | NMR | - | P | 25-31 | [»] | |
2WXW | X-ray | 3.30 | A | 25-476 | [»] | |
2X0B | X-ray | 4.33 | B/D/F/H | 25-476 | [»] | |
3CK0 | X-ray | 3.00 | P | 25-32 | [»] | |
3WOO | X-ray | 1.80 | C/D | 27-32 | [»] | |
3WOR | X-ray | 2.10 | C/D | 25-32 | [»] | |
4AA1 | X-ray | 1.99 | P | 25-32 | [»] | |
4APH | X-ray | 1.99 | P | 25-32 | [»] | |
4FYS | X-ray | 2.01 | C | 27-32 | [»] | |
5E2Q | X-ray | 2.40 | B | 25-32 | [»] | |
5M3X | X-ray | 2.63 | A/B | 35-476 | [»] | |
5M3Y | X-ray | 2.30 | A | 25-476 | [»] | |
5XJM | X-ray | 3.20 | B | 26-31 | [»] | |
6I3F | X-ray | 2.55 | A | 25-476 | [»] | |
6I3I | X-ray | 2.97 | A | 25-476 | [»] | |
6JOD | X-ray | 3.20 | B | 25-32 | [»] | |
6OS0 | X-ray | 2.90 | B | 25-32 | [»] | |
7C6A | X-ray | 3.40 | B | 26-31 | [»] | |
SMRi | P01019 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106690, 21 interactors |
CORUMi | P01019 |
DIPi | DIP-309N |
IntActi | P01019, 26 interactors |
MINTi | P01019 |
STRINGi | 9606.ENSP00000355627 |
Chemistry databases
ChEMBLi | CHEMBL3596085 |
DrugBanki | DB09130, Copper DB12548, Sparsentan DB01593, Zinc DB14487, Zinc acetate |
Protein family/group databases
MEROPSi | I04.953 |
PTM databases
CarbonylDBi | P01019 |
GlyConnecti | 703, 12 N-Linked glycans (3 sites) |
GlyGeni | P01019, 5 sites, 20 N-linked glycans (3 sites), 1 O-linked glycan (1 site) |
iPTMneti | P01019 |
PhosphoSitePlusi | P01019 |
Genetic variation databases
BioMutai | AGT |
DMDMi | 113880 |
2D gel databases
SWISS-2DPAGEi | P01019 |
Proteomic databases
EPDi | P01019 |
jPOSTi | P01019 |
MassIVEi | P01019 |
MaxQBi | P01019 |
PaxDbi | P01019 |
PeptideAtlasi | P01019 |
PRIDEi | P01019 |
ProteomicsDBi | 51306 |
Protocols and materials databases
ABCDi | P01019, 5 sequenced antibodies |
Antibodypediai | 866, 1056 antibodies from 42 providers |
DNASUi | 183 |
Genome annotation databases
Ensembli | ENST00000366667; ENSP00000355627; ENSG00000135744 |
GeneIDi | 183 |
UCSCi | uc001hty.6, human |
Organism-specific databases
CTDi | 183 |
DisGeNETi | 183 |
GeneCardsi | AGT |
HGNCi | HGNC:333, AGT |
HPAi | ENSG00000135744, Tissue enriched (liver) |
MalaCardsi | AGT |
MIMi | 106150, gene 145500, phenotype 267430, phenotype |
neXtProti | NX_P01019 |
Orphaneti | 243761, NON RARE IN EUROPE: Essential hypertension 97369, Renal tubular dysgenesis of genetic origin |
PharmGKBi | PA42 |
VEuPathDBi | HostDB:ENSG00000135744 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
HOGENOMi | CLU_045267_1_0_1 |
InParanoidi | P01019 |
OMAi | WAFTRQD |
OrthoDBi | 450590at2759 |
PhylomeDBi | P01019 |
TreeFami | TF343201 |
Enzyme and pathway databases
PathwayCommonsi | P01019 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P01019 |
SIGNORi | P01019 |
Miscellaneous databases
BioGRID-ORCSi | 183, 10 hits in 1039 CRISPR screens |
ChiTaRSi | AGT, human |
EvolutionaryTracei | P01019 |
GeneWikii | Angiotensin |
GenomeRNAii | 183 |
Pharosi | P01019, Tbio |
PROi | PR:P01019 |
RNActi | P01019, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135744, Expressed in liver and 223 other tissues |
ExpressionAtlasi | P01019, baseline and differential |
Genevisiblei | P01019, HS |
Family and domain databases
CDDi | cd02054, serpinA8_AGT, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR000227, Angiotensinogen IPR033834, Angiotensinogen_serpin_dom IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit PTHR11461:SF331, PTHR11461:SF331, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
PRINTSi | PR00654, ANGIOTENSNGN |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ANGT_HUMAN | |
Accessioni | P01019Primary (citable) accession number: P01019 Secondary accession number(s): Q16358, Q16359, Q96F91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 23, 2022 | |
Last modified: | February 23, 2022 | |
This is version 241 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families