Angiotensinogen

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• growth factor activity Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]
• hormone activity Source: BHF-UCL
• receptor ligand activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Downregulation of microRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes."
    Gao S., Liu T.W., Wang Z., Jiao Z.Y., Cai J., Chi H.J., Yang X.C.
    Cardiology 127:114-120(2014) [PubMed] [Europe PMC] [Abstract]
• serine-type endopeptidase inhibitor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sodium channel regulator activity Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump."
    De Mello W.C.
    J Renin Angiotensin Aldosterone Syst 5:203-208(2004) [PubMed] [Europe PMC] [Abstract]
  • "Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart."
    De Mello W.C., Ferrario C.M., Jessup J.A.
    J Renin Angiotensin Aldosterone Syst 8:74-80(2007) [PubMed] [Europe PMC] [Abstract]
• superoxide-generating NADPH oxidase activator activity Source: BHF-UCLTraceable author statementⁱ
  • "Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase."
    White C.N., Figtree G.A., Liu C.C., Garcia A., Hamilton E.J., Chia K.K., Rasmussen H.H.
    Am J Physiol Cell Physiol 296:C693-700(2009) [PubMed] [Europe PMC] [Abstract]
• type 1 angiotensin receptor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]
• type 2 angiotensin receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of MAPK activity Source: CACAOInferred from mutant phenotypeⁱ
  • "Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells."
    Zhang F., Li S., Song J., Liu J., Cui Y., Chen H.
    Atherosclerosis 261:90-98(2017) [PubMed] [Europe PMC] [Abstract]
• angiotensin-activated signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Downregulation of microRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes."
    Gao S., Liu T.W., Wang Z., Jiao Z.Y., Cai J., Chi H.J., Yang X.C.
    Cardiology 127:114-120(2014) [PubMed] [Europe PMC] [Abstract]
• blood vessel remodeling Source: BHF-UCLTraceable author statementⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: ProtIncTraceable author statementⁱ
  • Ref.26

    "A molecular variant of angiotensinogen associated with preeclampsia."
    Ward K., Hata A., Jeunemaitre X., Helin C., Nelson L., Namikawa C., Farrington P.F., Ogasawara M., Suzumori K., Tomoda S., Berrebi S., Sasaki M., Corvol P., Lifton R.P., Lalouel J.-M.
    Nat. Genet. 4:59-61(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT THR-268.
• G protein-coupled receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCLTraceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.30

    "Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."
    Gribouval O., Gonzales M., Neuhaus T., Aziza J., Bieth E., Laurent N., Bouton J.M., Feuillet F., Makni S., Ben Amar H., Laube G., Delezoide A.-L., Bouvier R., Dijoud F., Ollagnon-Roman E., Roume J., Joubert M., Antignac C., Gubler M.-C.
    Nat. Genet. 37:964-968(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT RTD GLN-375.
• low-density lipoprotein particle remodeling Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation."
    Luchtefeld M., Bandlow N., Tietge U.J., Grote K., Pfeilschifter J., Kaszkin M., Beck S., Drexler H., Schieffer B.
    Atherosclerosis 194:62-70(2007) [PubMed] [Europe PMC] [Abstract]
• maintenance of blood vessel diameter homeostasis by renin-angiotensin Source: BHF-UCLTraceable author statementⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of endopeptidase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • "Downregulation of microRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes."
    Gao S., Liu T.W., Wang Z., Jiao Z.Y., Cai J., Chi H.J., Yang X.C.
    Cardiology 127:114-120(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of MAP kinase activity Source: CACAOInferred from mutant phenotypeⁱ
  • "Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells."
    Zhang F., Li S., Song J., Liu J., Cui Y., Chen H.
    Atherosclerosis 261:90-98(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neurotrophin TRK receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of sodium ion transmembrane transporter activity Source: BHF-UCLTraceable author statementⁱ
  • "Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase."
    White C.N., Figtree G.A., Liu C.C., Garcia A., Hamilton E.J., Chia K.K., Rasmussen H.H.
    Am J Physiol Cell Physiol 296:C693-700(2009) [PubMed] [Europe PMC] [Abstract]
• nitric oxide mediated signal transduction Source: BHF-UCLTraceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of activation of Janus kinase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor."
    Zhang S.L., Moini B., Ingelfinger J.R.
    J Am Soc Nephrol 15:1452-1465(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKBInferred from direct assayⁱ
  • "Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis."
    Chen Y.W., Tran S., Chenier I., Chan J.S., Ingelfinger J.R., Inagami T., Zhang S.L.
    Pediatr Nephrol 23:1769-1777(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
• positive regulation of cellular protein metabolic process Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages."
    Kanome T., Watanabe T., Nishio K., Takahashi K., Hongo S., Miyazaki A.
    Hypertens Res 31:1801-1810(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cholesterol esterification Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages."
    Kanome T., Watanabe T., Nishio K., Takahashi K., Hongo S., Miyazaki A.
    Hypertens Res 31:1801-1810(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytokine production Source: BHF-UCLTraceable author statementⁱ
  • "Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression."
    Zhong J.C., Yu X.Y., Lin Q.X., Li X.H., Huang X.Z., Xiao D.Z., Lin S.G.
    Br J Pharmacol 153:66-74(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell migration Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells."
    Montiel M., de la Blanca E.P., Jimenez E.
    Biochem Biophys Res Commun 327:971-978(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells."
    Montiel M., de la Blanca E.P., Jimenez E.
    Biochem Biophys Res Commun 327:971-978(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fibroblast proliferation Source: BHF-UCL
• positive regulation of gap junction assembly Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Angiotensin II-induced sudden arrhythmic death and electrical remodeling."
    Fischer R., Dechend R., Gapelyuk A., Shagdarsuren E., Gruner K., Gruner A., Gratze P., Qadri F., Wellner M., Fiebeler A., Dietz R., Luft F.C., Muller D.N., Schirdewan A.
    Am J Physiol Heart Circ Physiol 293:H1242-53(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response Source: BHF-UCLTraceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
  • "Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression."
    Zhong J.C., Yu X.Y., Lin Q.X., Li X.H., Huang X.Z., Xiao D.Z., Lin S.G.
    Br J Pharmacol 153:66-74(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages."
    Kanome T., Watanabe T., Nishio K., Takahashi K., Hongo S., Miyazaki A.
    Hypertens Res 31:1801-1810(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of membrane hyperpolarization Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump."
    De Mello W.C.
    J Renin Angiotensin Aldosterone Syst 5:203-208(2004) [PubMed] [Europe PMC] [Abstract]
  • "Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart."
    De Mello W.C., Ferrario C.M., Jessup J.A.
    J Renin Angiotensin Aldosterone Syst 8:74-80(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NAD(P)H oxidase activity Source: BHF-UCLTraceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
  • "Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase."
    White C.N., Figtree G.A., Liu C.C., Garcia A., Hamilton E.J., Chia K.K., Rasmussen H.H.
    Am J Physiol Cell Physiol 296:C693-700(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NF-kappaB transcription factor activity Source: BHF-UCLTraceable author statementⁱ
  • "Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression."
    Zhong J.C., Yu X.Y., Lin Q.X., Li X.H., Huang X.Z., Xiao D.Z., Lin S.G.
    Br J Pharmacol 153:66-74(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells."
    Montiel M., de la Blanca E.P., Jimenez E.
    Biochem Biophys Res Commun 327:971-978(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells."
    Montiel M., de la Blanca E.P., Jimenez E.
    Biochem Biophys Res Commun 327:971-978(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein tyrosine kinase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor."
    Zhang S.L., Moini B., Ingelfinger J.R.
    J Am Soc Nephrol 15:1452-1465(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of reactive oxygen species metabolic process Source: BHF-UCLTraceable author statementⁱ
  • "Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression."
    Zhong J.C., Yu X.Y., Lin Q.X., Li X.H., Huang X.Z., Xiao D.Z., Lin S.G.
    Br J Pharmacol 153:66-74(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • "Downregulation of microRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes."
    Gao S., Liu T.W., Wang Z., Jiao Z.Y., Cai J., Chi H.J., Yang X.C.
    Cardiology 127:114-120(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of blood pressure Source: BHF-UCLInferred from genetic interactionⁱ
  • "Angiotensin II-induced sudden arrhythmic death and electrical remodeling."
    Fischer R., Dechend R., Gapelyuk A., Shagdarsuren E., Gruner K., Gruner A., Gratze P., Qadri F., Wellner M., Fiebeler A., Dietz R., Luft F.C., Muller D.N., Schirdewan A.
    Am J Physiol Heart Circ Physiol 293:H1242-53(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of blood volume by renin-angiotensin Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cardiac conduction Source: BHF-UCLInferred from genetic interactionⁱ
  • "Angiotensin II-induced sudden arrhythmic death and electrical remodeling."
    Fischer R., Dechend R., Gapelyuk A., Shagdarsuren E., Gruner K., Gruner A., Gratze P., Qadri F., Wellner M., Fiebeler A., Dietz R., Luft F.C., Muller D.N., Schirdewan A.
    Am J Physiol Heart Circ Physiol 293:H1242-53(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell growth Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of extracellular matrix assembly Source: BHF-UCLInferred from genetic interactionⁱ
  • "Angiotensin II-induced sudden arrhythmic death and electrical remodeling."
    Fischer R., Dechend R., Gapelyuk A., Shagdarsuren E., Gruner K., Gruner A., Gratze P., Qadri F., Wellner M., Fiebeler A., Dietz R., Luft F.C., Muller D.N., Schirdewan A.
    Am J Physiol Heart Circ Physiol 293:H1242-53(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of metabolic process Source: Reactome
• regulation of renal output by angiotensin Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of renal sodium excretion Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of vasoconstriction Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• renal system process Source: UniProtKBInferred from direct assayⁱ
  • "Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease."
    Butte A.J., Sigdel T.K., Wadia P.P., Miklos D.B., Sarwal M.M.
    Mol Cell Proteomics 10:M110.000497-M110.000497(2011) [PubMed] [Europe PMC] [Abstract]
• renin-angiotensin regulation of aldosterone production Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• response to muscle activity involved in regulation of muscle adaptation Source: BHF-UCL
• vasoconstriction Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• growth factor activity Source: BHF-UCLTraceable author statementⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]
• hormone activity Source: BHF-UCL
• receptor ligand activity Source: BHF-UCLInferred from direct assayⁱ
  • "Downregulation of microRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes."
    Gao S., Liu T.W., Wang Z., Jiao Z.Y., Cai J., Chi H.J., Yang X.C.
    Cardiology 127:114-120(2014) [PubMed] [Europe PMC] [Abstract]
• type 1 angiotensin receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]
• type 2 angiotensin receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."
    Lehtonen J.Y., Daviet L., Nahmias C., Horiuchi M., Dzau V.J.
    Mol Endocrinol 13:1051-1060(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST 
        60         70         80         90        100
CEQLAKANAG KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK 
       110        120        130        140        150
LRAAMVGMLA NFLGFRIYGM HSELWGVVHG ATVLSPTAVF GTLASLYLGA 
       160        170        180        190        200
LDHTADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ 
       210        220        230        240        250
AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK 
       260        270        280        290        300
IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF 
       310        320        330        340        350
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA 
       360        370        380        390        400
SDLDKVEGLT FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE 
       410        420        430        440        450
LPAILHTELN LQKLSNDRIR VGEVLNSIFF ELEADEREPT ESTQQLNKPE 
       460        470        480 
VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN PLSTA                 

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families