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Protein

Ovomucoid

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease inhibitor. Inhibits trypsin.1 Publication

pH dependencei

No decrease in activity observed after incubating at pH 2.5 and pH 7.4 for 1 hour. Retains 20% activity after incubation at pH 12 for 1 hour.1 Publication

Temperature dependencei

No decrease in activity observed after heating for 1 hour at up to 80 degrees Celsius. Retains 20% activity after incubation at 95 degrees Celsius for 1 hour.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48 – 49Reactive bond 1 for endoproteinase Lys-C2
Sitei113 – 114Reactive bond 2 for trypsin2
Sitei172 – 173Reactive bond 32

GO - Molecular functioni

  • carbohydrate binding Source: AgBase
  • IgE binding Source: AgBase
  • IgG binding Source: AgBase
  • serine-type endopeptidase inhibitor activity Source: AgBase

GO - Biological processi

  • response to steroid hormone Source: AgBase

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-GGA-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiI01.001

Names & Taxonomyi

Protein namesi
Recommended name:
Ovomucoid
Alternative name(s):
Allergen Gal d I
Allergen: Gal d 1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3291 Gal d 1.0101
359 Gal d 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001657925 – 210OvomucoidAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 68
Glycosylationi34N-linked (GlcNAc...) asparagine1
Disulfide bondi46 ↔ 65
Disulfide bondi54 ↔ 86
Glycosylationi77N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi93N-linked (GlcNAc...) asparagine1
Disulfide bondi94 ↔ 133
Glycosylationi99N-linked (GlcNAc...) asparagine1
Disulfide bondi111 ↔ 130
Disulfide bondi119 ↔ 151
Disulfide bondi162 ↔ 192
Disulfide bondi170 ↔ 189
Disulfide bondi178 ↔ 210
Glycosylationi199N-linked (GlcNAc...) asparagine; partial1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01005
PRIDEiP01005

PTM databases

GlyConnecti479
iPTMnetiP01005
UniCarbKBiP01005

Expressioni

Gene expression databases

BgeeiENSGALG00000003512 Expressed in 8 organ(s), highest expression level in liver
ExpressionAtlasiP01005 differential

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005544

Structurei

3D structure databases

ProteinModelPortaliP01005
SMRiP01005
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 88Kazal-like 1PROSITE-ProRule annotationAdd BLAST64
Domaini89 – 153Kazal-like 2PROSITE-ProRule annotationAdd BLAST65
Domaini156 – 210Kazal-like 3PROSITE-ProRule annotationAdd BLAST55

Domaini

Avian ovomucoid consists of three homologous, tandem Kazal family inhibitory domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J2J1 Eukaryota
ENOG411282Y LUCA
GeneTreeiENSGT00510000048608
HOGENOMiHOG000113088
HOVERGENiHBG006172
InParanoidiP01005
PhylomeDBiP01005
TreeFamiTF352550

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 3 hits
SMARTiView protein in SMART
SM00280 KAZAL, 3 hits
SUPFAMiSSF100895 SSF100895, 3 hits
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 3 hits
PS51465 KAZAL_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01005-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMAGVFVLF SFVLCGFLPD AAFGAEVDCS RFPNATDKEG KDVLVCNKDL
60 70 80 90 100
RPICGTDGVT YTNDCLLCAY SIEFGTNISK EHDGECKETV PMNCSSYANT
110 120 130 140 150
TSEDGKVMVL CNRAFNPVCG TDGVTYDNEC LLCAHKVEQG ASVDKRHDGG
160 170 180 190 200
CRKELAAVSV DCSEYPKPDC TAEDRPLCGS DNKTYGNKCN FCNAVVESNG
210
TLTLSHFGKC
Length:210
Mass (Da):22,591
Last modified:July 21, 1986 - v1
Checksum:i8BE9516B6D38ACF9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5NYW0A0A1D5NYW0_CHICK
Uncharacterized protein
SPIK7
201Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62T → N AA sequence (PubMed:3548816).Curated1
Sequence conflicti64D → E AA sequence (PubMed:3548816).Curated1
Sequence conflicti108M → T AA sequence (PubMed:3548816).Curated1
Sequence conflicti150G → E AA sequence (PubMed:3548816).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti158 – 159Missing Due to an ambiguous intron excision. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00902 mRNA No translation available.
PIRiA92754 TICHM
RefSeqiNP_001295423.1, NM_001308494.1
XP_015149249.1, XM_015293763.1
UniGeneiGga.5085
Gga.51528

Genome annotation databases

EnsembliENSGALT00000005554; ENSGALP00000005544; ENSGALG00000003512
GeneIDi416236
KEGGigga:416236

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00902 mRNA No translation available.
PIRiA92754 TICHM
RefSeqiNP_001295423.1, NM_001308494.1
XP_015149249.1, XM_015293763.1
UniGeneiGga.5085
Gga.51528

3D structure databases

ProteinModelPortaliP01005
SMRiP01005
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005544

Protein family/group databases

Allergomei3291 Gal d 1.0101
359 Gal d 1
MEROPSiI01.001

PTM databases

GlyConnecti479
iPTMnetiP01005
UniCarbKBiP01005

Proteomic databases

PaxDbiP01005
PRIDEiP01005

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005554; ENSGALP00000005544; ENSGALG00000003512
GeneIDi416236
KEGGigga:416236

Organism-specific databases

CTDi416236

Phylogenomic databases

eggNOGiENOG410J2J1 Eukaryota
ENOG411282Y LUCA
GeneTreeiENSGT00510000048608
HOGENOMiHOG000113088
HOVERGENiHBG006172
InParanoidiP01005
PhylomeDBiP01005
TreeFamiTF352550

Enzyme and pathway databases

ReactomeiR-GGA-6809371 Formation of the cornified envelope

Miscellaneous databases

PROiPR:P01005

Gene expression databases

BgeeiENSGALG00000003512 Expressed in 8 organ(s), highest expression level in liver
ExpressionAtlasiP01005 differential

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 3 hits
SMARTiView protein in SMART
SM00280 KAZAL, 3 hits
SUPFAMiSSF100895 SSF100895, 3 hits
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 3 hits
PS51465 KAZAL_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIOVO_CHICK
AccessioniPrimary (citable) accession number: P01005
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 10, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
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