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Protein

Pancreatic trypsin inhibitor

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei50 – 51Reactive bond for trypsin2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.001

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic trypsin inhibitor
Alternative name(s):
Aprotinin
Basic protease inhibitor
Short name:
BPI
Short name:
BPTI
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Previously available under the name Trasylol (Mile). Used for inhibiting coagulation so as to reduce blood loss during bypass surgery.

Protein family/group databases

Allergomei3890 Bos d TI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001685222 – 35Add BLAST14
ChainiPRO_000001685336 – 93Pancreatic trypsin inhibitorAdd BLAST58
PropeptideiPRO_000001685494 – 1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 90
Disulfide bondi49 ↔ 73PROSITE-ProRule annotation1 Publication
Disulfide bondi65 ↔ 86PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP00974

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-6113N
IntActiP00974, 5 interactors
MINTiP00974

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00729
ProteinModelPortaliP00974
SMRiP00974
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP00974

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 90BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000007327
HOVERGENiHBG006193

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SUPFAMiSSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P00974-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMSRLCLSV ALLVLLGTLA ASTPGCDTSN QAKAQRPDFC LEPPYTGPCK
60 70 80 90 100
ARIIRYFYNA KAGLCQTFVY GGCRAKRNNF KSAEDCMRTC GGAIGPWENL
Length:100
Mass (Da):10,903
Last modified:July 1, 1989 - v2
Checksum:i6A778A4AD763FB19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20934, M20930, M20932 Genomic DNA Translation: AAD13685.1
X03365 Genomic DNA Translation: CAA27062.1 Sequence problems.
X03365 Genomic DNA Translation: CAA27063.1
X05274 mRNA Translation: CAA28886.1
PIRiS00277 TIBO
UniGeneiBt.28518

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20934, M20930, M20932 Genomic DNA Translation: AAD13685.1
X03365 Genomic DNA Translation: CAA27062.1 Sequence problems.
X03365 Genomic DNA Translation: CAA27063.1
X05274 mRNA Translation: CAA28886.1
PIRiS00277 TIBO
UniGeneiBt.28518

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AALX-ray1.60A/B36-93[»]
1B0CX-ray2.80A/B/C/D/E36-91[»]
1BHCX-ray2.70A/B/C/D/E/F/G/H/I/J36-93[»]
1BPIX-ray1.09A36-93[»]
1BPTX-ray2.00A36-93[»]
1BRBX-ray2.10I36-93[»]
1BTHX-ray2.30P/Q36-93[»]
1BTIX-ray2.20A36-93[»]
1BZ5X-ray2.58A/B/C/D/E36-93[»]
1BZXX-ray2.10I36-93[»]
1CBWX-ray2.60D/I36-93[»]
1CO7X-ray1.90I2-100[»]
1D0DX-ray1.62B36-93[»]
1EAWX-ray2.93B/D36-93[»]
1EJMX-ray1.85B/D/F36-93[»]
1F5RX-ray1.65I36-100[»]
1F7ZX-ray1.55I36-100[»]
1FAKX-ray2.10I37-90[»]
1FANX-ray2.00A36-93[»]
1FY8X-ray1.70I36-93[»]
1G6XX-ray0.86A36-93[»]
1JV8NMR-A36-93[»]
1JV9NMR-A36-93[»]
1K09NMR-A/B50-73[»]
1K6UX-ray1.00A36-93[»]
1LD5NMR-A36-93[»]
1LD6NMR-A36-93[»]
1MTNX-ray2.80D/H36-93[»]
1NAGX-ray1.90A36-93[»]
1OA5NMR-536-93[»]
1OA6NMR-536-93[»]
1P2IX-ray1.65I36-93[»]
1P2JX-ray1.35I36-93[»]
1P2KX-ray1.60I36-93[»]
1P2MX-ray1.75B/D36-93[»]
1P2NX-ray1.80B/D36-93[»]
1P2OX-ray2.00B/D36-93[»]
1P2QX-ray1.80B/D36-93[»]
1PITNMR-A36-93[»]
1QLQX-ray1.42A36-93[»]
1T7CX-ray1.85B/D36-93[»]
1T8LX-ray1.75B/D36-93[»]
1T8MX-ray1.80B/D36-93[»]
1T8NX-ray1.75B/D36-93[»]
1T8OX-ray1.70B/D36-93[»]
1TPAX-ray1.90I36-93[»]
1UUANMR-A38-93[»]
1UUBNMR-A38-93[»]
1YKTX-ray1.70B36-91[»]
1YLCX-ray1.70B36-91[»]
1YLDX-ray1.70B36-91[»]
2FI3X-ray1.58I36-93[»]
2FI4X-ray1.58I36-93[»]
2FI5X-ray1.58I36-93[»]
2FTLX-ray1.62I36-93[»]
2FTMX-ray1.65B36-93[»]
2HEXX-ray2.10A/B/C/D/E36-93[»]
2IJOX-ray2.30I36-93[»]
2KAIX-ray2.50I36-93[»]
2PTCX-ray1.90I36-93[»]
2R9PX-ray1.40E/F/G/I36-93[»]
2RA3X-ray1.46C/I36-93[»]
2TGPX-ray1.90I36-93[»]
2TPIX-ray2.10I36-93[»]
2ZJXX-ray1.09A/B36-93[»]
2ZVXX-ray1.09A/B36-93[»]
3BTDX-ray1.90I36-93[»]
3BTEX-ray1.85I36-93[»]
3BTFX-ray1.80I36-93[»]
3BTGX-ray1.90I36-93[»]
3BTHX-ray1.75I36-93[»]
3BTKX-ray1.85I36-93[»]
3BTMX-ray1.80I36-93[»]
3BTQX-ray1.90I36-93[»]
3BTTX-ray1.90I36-93[»]
3BTWX-ray2.05I36-93[»]
3FP6X-ray1.49I36-93[»]
3FP7X-ray1.46I36-50[»]
J51-93[»]
3FP8X-ray1.46I36-93[»]
3GYMX-ray2.80I/J36-93[»]
3LDIX-ray2.20A/B/C/D/E36-93[»]
3LDJX-ray1.70A/B/C36-93[»]
3LDMX-ray2.60A/B/C/D/E36-93[»]
3OTJOther2.15I36-93[»]
3P92X-ray1.60E36-93[»]
3P95X-ray1.30E36-93[»]
3TGIX-ray1.80I36-100[»]
3TGJX-ray2.20I36-100[»]
3TGKX-ray1.70I36-100[»]
3TPIX-ray1.90I36-93[»]
3U1JX-ray1.80E36-93[»]
3WNYX-ray1.30A/B/C/E/F/G/H/I36-95[»]
4BNRX-ray2.00I/J1-100[»]
4DG4X-ray1.40C/E/F/H36-93[»]
4PTIX-ray1.50A36-93[»]
4TPIX-ray2.20I36-93[»]
4WWYX-ray1.70C/I36-93[»]
4WXVX-ray2.10C/I36-90[»]
4Y0YX-ray1.25I36-93[»]
4Y0ZX-ray1.37I36-93[»]
4Y10X-ray1.37I36-93[»]
4Y11X-ray1.30I36-93[»]
5JB4X-ray1.99A/B/C36-93[»]
5JB5X-ray1.60A/B/C36-93[»]
5JB6X-ray1.90A/B/C36-93[»]
5JB7X-ray1.90A/B/C36-93[»]
5PTIX-ray1.00A36-93[»]
5XX2X-ray1.12A/B36-93[»]
5XX3X-ray1.12A/B36-93[»]
5XX4X-ray1.67A/B36-93[»]
5XX5X-ray1.38A/B36-93[»]
5XX6X-ray1.31A/B36-93[»]
5XX7X-ray1.38A/D36-93[»]
5XX8X-ray1.30A/B36-93[»]
6F1FX-ray1.72A/B/C/D/E36-93[»]
6PTIX-ray1.70A36-93[»]
7PTIX-ray1.60A36-93[»]
8PTIX-ray1.80A36-93[»]
9PTIX-ray1.22A36-93[»]
DisProtiDP00729
ProteinModelPortaliP00974
SMRiP00974
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6113N
IntActiP00974, 5 interactors
MINTiP00974

Protein family/group databases

Allergomei3890 Bos d TI
MEROPSiI02.001

Proteomic databases

PRIDEiP00974

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000007327
HOVERGENiHBG006193

Miscellaneous databases

EvolutionaryTraceiP00974

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SUPFAMiSSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBPT1_BOVIN
AccessioniPrimary (citable) accession number: P00974
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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