UniProtKB - P00973 (OAS1_HUMAN)
2'-5'-oligoadenylate synthase 1
OAS1
Functioni
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622).
In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34581622).
Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
5 PublicationsWhen prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target (PubMed:34581622).
The same mechanism is necessary to initiate a block to cardiovirus EMCV (PubMed:34581622).
1 PublicationNot prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.
1 PublicationCaution
Catalytic activityi
- EC:2.7.7.847 Publications
Cofactori
Activity regulationi
Kineticsi
- KM=0.31 mM for ATP1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 63 | ATPCombined sources1 Publication | 1 | |
Metal bindingi | 75 | Magnesium; catalyticCombined sources1 Publication | 1 | |
Metal bindingi | 77 | Magnesium; catalyticCombined sources1 Publication | 1 | |
Metal bindingi | 148 | Magnesium; catalyticCombined sources1 Publication | 1 | |
Binding sitei | 210 | ATPBy similarity | 1 | |
Binding sitei | 213 | ATPCombined sources1 Publication | 1 | |
Binding sitei | 229 | ATPCombined sources1 Publication | 1 |
GO - Molecular functioni
- 2'-5'-oligoadenylate synthetase activity Source: ARUK-UCL
- ATP binding Source: UniProtKB
- double-stranded RNA binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- antiviral innate immune response Source: ARUK-UCL
- cellular response to interferon-alpha Source: UniProtKB
- cellular response to interferon-beta Source: ARUK-UCL
- cellular response to virus Source: ARUK-UCL
- defense response to bacterium Source: ARUK-UCL
- defense response to virus Source: UniProtKB
- glucose homeostasis Source: UniProtKB
- glucose metabolic process Source: UniProtKB
- interleukin-27-mediated signaling pathway Source: ARUK-UCL
- negative regulation of chemokine (C-X-C motif) ligand 2 production Source: ARUK-UCL
- negative regulation of IP-10 production Source: ARUK-UCL
- negative regulation of type I interferon-mediated signaling pathway Source: ARUK-UCL
- negative regulation of viral genome replication Source: UniProtKB
- positive regulation of cellular respiration Source: ARUK-UCL
- positive regulation of interferon-beta production Source: ARUK-UCL
- positive regulation of monocyte chemotactic protein-1 production Source: ARUK-UCL
- positive regulation of tumor necrosis factor production Source: ARUK-UCL
- protein complex oligomerization Source: UniProtKB
- regulation of ribonuclease activity Source: ARUK-UCL
- response to virus Source: UniProtKB
- surfactant homeostasis Source: ARUK-UCL
- toll-like receptor 3 signaling pathway Source: ARUK-UCL
- toll-like receptor 4 signaling pathway Source: ARUK-UCL
- type I interferon signaling pathway Source: ARUK-UCL
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-binding, Transferase |
Biological process | Antiviral defense, Immunity, Innate immunity |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.7.84, 2681 |
PathwayCommonsi | P00973 |
Reactomei | R-HSA-877300, Interferon gamma signaling R-HSA-8983711, OAS antiviral response R-HSA-909733, Interferon alpha/beta signaling |
SABIO-RKi | P00973 |
SignaLinki | P00973 |
Names & Taxonomyi
Protein namesi | Recommended name: 2'-5'-oligoadenylate synthase 1 (EC:2.7.7.847 Publications)Short name: (2-5')oligo(A) synthase 1 Short name: 2-5A synthase 1 Alternative name(s): E18/E16 p46/p42 OAS |
Gene namesi | Name:OAS1 Synonyms:OIAS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8086, OAS1 |
MIMi | 164350, gene |
neXtProti | NX_P00973 |
VEuPathDBi | HostDB:ENSG00000089127 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 3 Publications
Endoplasmic reticulum
- Microsome 1 Publication
- Endoplasmic reticulum 1 Publication
Nucleus
- Nucleus 2 Publications
Extracellular region or secreted
- Secreted By similarity
Mitochondrion
- Mitochondrion 1 Publication
Note: Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.1 Publication
- Note: (Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, prenylated form localizes to membranous perinuclear structures reminiscent of the endoplasmic reticulum rich in viral dsRNA which are SARS-CoV-2 replicative organelles.1 Publication
- Note: (Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, since its not prenylated, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.1 Publication
Cytosol
- cytosol Source: ARUK-UCL
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: ARUK-UCL
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: ARUK-UCL
Other locations
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 66 | K → A: Decreased enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 75 | D → A: Loss of activity; when associated with A-77. 2 Publications | 1 | |
Mutagenesisi | 77 | D → A: Loss of activity; when associated with A-75. 2 Publications | 1 | |
Mutagenesisi | 148 | D → A: Strongly reduced enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 233 | E → A: Loss of enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 331 | C → A: Loss of activity; when associated with A-332 and A-333. 1 Publication | 1 | |
Mutagenesisi | 332 | F → A: Loss of activity; when associated with A-331 and A-333. 1 Publication | 1 | |
Mutagenesisi | 333 | K → A: Loss of activity; when associated with A-331 and A-332. 1 Publication | 1 | |
Mutagenesisi | 397 | C → A: Not prenylated and diffusely distributed. Loss of antiviral activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4938 |
MalaCardsi | OAS1 |
OpenTargetsi | ENSG00000089127 |
Orphaneti | 572428, Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia |
PharmGKBi | PA31875 |
Miscellaneous databases
Pharosi | P00973, Tbio |
Chemistry databases
DrugBanki | DB02987, Cysteine-S-acetamide |
Genetic variation databases
BioMutai | OAS1 |
DMDMi | 296439492 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160259 | 1 – 400 | 2'-5'-oligoadenylate synthase 1Add BLAST | 400 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 397 | S-geranylgeranyl cysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, PrenylationProteomic databases
EPDi | P00973 |
jPOSTi | P00973 |
MassIVEi | P00973 |
MaxQBi | P00973 |
PaxDbi | P00973 |
PeptideAtlasi | P00973 |
PRIDEi | P00973 |
ProteomicsDBi | 29167 51294 [P00973-1] 51295 [P00973-2] 51296 [P00973-3] 51297 [P00973-4] |
PTM databases
iPTMneti | P00973 |
PhosphoSitePlusi | P00973 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000089127, Expressed in ectocervix and 208 other tissues |
ExpressionAtlasi | P00973, baseline and differential |
Genevisiblei | P00973, HS |
Organism-specific databases
HPAi | ENSG00000089127, Tissue enhanced (salivary gland, urinary bladder) |
Interactioni
Subunit structurei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 158 | Interaction with dsRNACombined sources | 1 |
Binary interactionsi
P00973
With | #Exp. | IntAct |
---|---|---|
ACTN1 [P12814] | 4 | EBI-3932815,EBI-351710 |
EXOC5 [O00471] | 3 | EBI-3932815,EBI-949824 |
PRMT6 [Q96LA8] | 2 | EBI-3932815,EBI-912440 |
TRIM27 [P14373] | 5 | EBI-3932815,EBI-719493 |
Isoform p42 [P00973-2]
Protein-protein interaction databases
BioGRIDi | 110992, 16 interactors |
IntActi | P00973, 15 interactors |
MINTi | P00973 |
STRINGi | 9606.ENSP00000388001 |
Miscellaneous databases
RNActi | P00973, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P00973 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 13 – 60 | Interaction with dsRNACombined sources1 PublicationAdd BLAST | 48 | |
Regioni | 200 – 210 | Interaction with dsRNACombined sources1 PublicationAdd BLAST | 11 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502RH25, Eukaryota KOG0001, Eukaryota COG5272, LUCA |
GeneTreei | ENSGT00510000046406 |
OMAi | HWYQKCK |
OrthoDBi | 866189at2759 |
PhylomeDBi | P00973 |
TreeFami | TF329749 |
Family and domain databases
CDDi | cd05400, NT_2-5OAS_ClassI-CCAase, 1 hit |
Gene3Di | 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR018952, 2-5-oligoAdlate_synth_1_dom2/C IPR026774, 2-5A_synthase IPR006117, 2-5OAS_C_CS IPR043518, 2-5OAS_N_CS IPR006116, NT_2-5OAS_ClassI-CCAase IPR043519, NT_sf IPR002934, Polymerase_NTP_transf_dom |
PANTHERi | PTHR11258, PTHR11258, 1 hit |
Pfami | View protein in Pfam PF01909, NTP_transf_2, 1 hit PF10421, OAS1_C, 1 hit |
SUPFAMi | SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS00832, 25A_SYNTH_1, 1 hit PS00833, 25A_SYNTH_2, 1 hit PS50152, 25A_SYNTH_3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS
60 70 80 90 100
YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ
110 120 130 140 150
EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL
160 170 180 190 200
PAFDALGQLT GGYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ
210 220 230 240 250
RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN
260 270 280 290 300
TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD
310 320 330 340 350
PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLAESN
360 370 380 390 400
SADDETDDPR RYQKYGYIGT HEYPHFSHRP STLQAASTPQ AEEDWTCTIL
The sequence of this isoform differs from the canonical sequence as follows:
347-364: AESNSADDETDDPRRYQK → VRPPASSLPFIPAPLHEA
365-400: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
347-400: AESNSADDET...AEEDWTCTIL → TQHTPGSIHP...CIIQDRTQVS
The sequence of this isoform differs from the canonical sequence as follows:
347-360: AESNSADDETDDPR → VNLTLVGRRNYTNN
361-400: Missing.
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6Q8PHR1 | A0A6Q8PHR1_HUMAN | 2'-5' oligoadenylate synthase | OAS1 | 356 | Annotation score: | ||
H0YIB8 | H0YIB8_HUMAN | 2'-5' oligoadenylate synthase | OAS1 | 384 | Annotation score: | ||
S4R3A5 | S4R3A5_HUMAN | 2'-5' oligoadenylate synthase | OAS1 | 403 | Annotation score: | ||
S4R467 | S4R467_HUMAN | 2'-5' oligoadenylate synthase | OAS1 | 361 | Annotation score: | ||
A0A7P0Z4N8 | A0A7P0Z4N8_HUMAN | 2'-5' oligoadenylate synthase | OAS1 | 392 | Annotation score: | ||
A0A7P0T854 | A0A7P0T854_HUMAN | 2'-5' oligoadenylate synthase | OAS1 | 353 | Annotation score: | ||
A0A7P0T879 | A0A7P0T879_HUMAN | 2'-5' oligoadenylate synthase | OAS1 | 407 | Annotation score: | ||
A0A7P0TBG0 | A0A7P0TBG0_HUMAN | 2'-5' oligoadenylate synthase | OAS1 | 405 | Annotation score: | ||
F8VPW7 | F8VPW7_HUMAN | 2'-5'-oligoadenylate synthase 1 | OAS1 | 306 | Annotation score: | ||
A0A7P0T8E1 | A0A7P0T8E1_HUMAN | 2'-5'-oligoadenylate synthase 1 | OAS1 | 408 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 18 | D → E in AAA39857 (PubMed:1651324).Curated | 1 | ||
Sequence conflicti | 111 | R → S in AAH71981 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 115 | F → L in AAB59552 (PubMed:2416561).Curated | 1 | ||
Sequence conflicti | 115 | F → L in AAB59553 (PubMed:2416561).Curated | 1 | ||
Sequence conflicti | 115 | F → L in CAA26633 (PubMed:2416561).Curated | 1 | ||
Sequence conflicti | 120 | E → V in BAD96726 (Ref. 10) Curated | 1 | ||
Sequence conflicti | 122 | Q → QE in AAA39858 (PubMed:1651324).Curated | 1 | ||
Sequence conflicti | 157 | G → D in AAA39857 (PubMed:1651324).Curated | 1 | ||
Sequence conflicti | 176 | E → D in AAA39858 (PubMed:1651324).Curated | 1 | ||
Sequence conflicti | 295 | R → T in CAB51602 (PubMed:3753689).Curated | 1 | ||
Sequence conflicti | 315 | G → R in CAB51602 (PubMed:3753689).Curated | 1 | ||
Isoform p48 (identifier: P00973-3) | |||||
Sequence conflicti | 397 | G → R in AAA39858 (PubMed:1651324).Curated | 1 | ||
Sequence conflicti | 397 | G → R in AAW63050 (PubMed:17024523).Curated | 1 | ||
Sequence conflicti | 397 | G → R in CAA26497 (PubMed:2411547).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060471 | 31 | N → D1 PublicationCorresponds to variant dbSNP:rs1050994Ensembl. | 1 | |
Natural variantiVAR_060472 | 127 | G → R. Corresponds to variant dbSNP:rs4767022Ensembl. | 1 | |
Natural variantiVAR_034872 | 162 | G → S9 PublicationsCorresponds to variant dbSNP:rs1131454EnsemblClinVar. | 1 | |
Natural variantiVAR_060473 | 352 | A → T3 PublicationsCorresponds to variant dbSNP:rs1131476Ensembl. | 1 | |
Natural variantiVAR_057658 | 354 | D → G. Corresponds to variant dbSNP:rs35919998Ensembl. | 1 | |
Natural variantiVAR_057659 | 361 | R → T3 PublicationsCorresponds to variant dbSNP:rs1051042Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003740 | 347 – 400 | AESNS…TCTIL → TQHTPGSIHPTGRRGLDLHH PLNASASWGKGLQCYLDQFL HFQVGLLIQRGQSSSVSWCI IQDRTQVS in isoform p48. 2 PublicationsAdd BLAST | 54 | |
Alternative sequenceiVSP_003738 | 347 – 364 | AESNS…RRYQK → VRPPASSLPFIPAPLHEA in isoform p42. 8 PublicationsAdd BLAST | 18 | |
Alternative sequenceiVSP_060747 | 347 – 360 | AESNS…TDDPR → VNLTLVGRRNYTNN in isoform p44. Add BLAST | 14 | |
Alternative sequenceiVSP_060748 | 361 – 400 | Missing in isoform p44. Add BLAST | 40 | |
Alternative sequenceiVSP_003739 | 365 – 400 | Missing in isoform p42. 8 PublicationsAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11809 , M11805, M11806, M11807, M11808 Genomic DNA Translation: AAB59552.1 M11810 Genomic DNA Translation: AAB59553.1 X02874 mRNA Translation: CAA26633.1 X02875 mRNA Translation: CAA26634.1 X04371 mRNA Translation: CAB51602.1 D00068 mRNA Translation: BAA00047.1 M63849 Genomic DNA Translation: AAA39857.1 Different initiation. M63850 Genomic DNA Translation: AAA39858.1 Different initiation. AJ629455 mRNA Translation: CAF33358.1 Frameshift. AY730628 mRNA Translation: AAW63050.1 DQ445949 Genomic DNA Translation: ABE27977.1 AK291003 mRNA Translation: BAF83692.1 BT006785 mRNA Translation: AAP35431.1 AK223006 mRNA Translation: BAD96726.1 Different initiation. AC004551 Genomic DNA No translation available. BC000562 mRNA Translation: AAH00562.4 BC061587 mRNA Translation: AAH61587.1 BC071981 mRNA Translation: AAH71981.3 X06560 Genomic DNA Translation: CAA29803.1 M18099 Genomic DNA Translation: AAA59955.1 Different initiation. X07179 Genomic DNA Translation: CAA30164.1 Different initiation. X02661 mRNA Translation: CAA26497.1 Sequence problems. |
CCDSi | CCDS31905.1 [P00973-3] CCDS41838.1 [P00973-1] CCDS44980.1 [P00973-2] CCDS81742.1 [P00973-4] |
PIRi | A39417, SYMSO2 A91013, SYHU16 B24359, SYHU18 B39417, SYMSO3 |
RefSeqi | NP_001027581.1, NM_001032409.2 [P00973-3] NP_001307080.1, NM_001320151.1 [P00973-4] NP_002525.2, NM_002534.3 [P00973-2] NP_058132.2, NM_016816.3 [P00973-1] |
Genome annotation databases
Ensembli | ENST00000202917; ENSP00000202917; ENSG00000089127 ENST00000445409; ENSP00000388001; ENSG00000089127 [P00973-3] ENST00000452357; ENSP00000415721; ENSG00000089127 [P00973-2] ENST00000551241; ENSP00000448790; ENSG00000089127 [P00973-4] ENST00000680189; ENSP00000505572; ENSG00000089127 ENST00000681934; ENSP00000505482; ENSG00000089127 |
GeneIDi | 4938 |
KEGGi | hsa:4938 |
MANE-Selecti | ENST00000202917.10; ENSP00000202917.5; NM_016816.4; NP_058132.2 |
UCSCi | uc001tub.4, human [P00973-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11809 , M11805, M11806, M11807, M11808 Genomic DNA Translation: AAB59552.1 M11810 Genomic DNA Translation: AAB59553.1 X02874 mRNA Translation: CAA26633.1 X02875 mRNA Translation: CAA26634.1 X04371 mRNA Translation: CAB51602.1 D00068 mRNA Translation: BAA00047.1 M63849 Genomic DNA Translation: AAA39857.1 Different initiation. M63850 Genomic DNA Translation: AAA39858.1 Different initiation. AJ629455 mRNA Translation: CAF33358.1 Frameshift. AY730628 mRNA Translation: AAW63050.1 DQ445949 Genomic DNA Translation: ABE27977.1 AK291003 mRNA Translation: BAF83692.1 BT006785 mRNA Translation: AAP35431.1 AK223006 mRNA Translation: BAD96726.1 Different initiation. AC004551 Genomic DNA No translation available. BC000562 mRNA Translation: AAH00562.4 BC061587 mRNA Translation: AAH61587.1 BC071981 mRNA Translation: AAH71981.3 X06560 Genomic DNA Translation: CAA29803.1 M18099 Genomic DNA Translation: AAA59955.1 Different initiation. X07179 Genomic DNA Translation: CAA30164.1 Different initiation. X02661 mRNA Translation: CAA26497.1 Sequence problems. |
CCDSi | CCDS31905.1 [P00973-3] CCDS41838.1 [P00973-1] CCDS44980.1 [P00973-2] CCDS81742.1 [P00973-4] |
PIRi | A39417, SYMSO2 A91013, SYHU16 B24359, SYHU18 B39417, SYMSO3 |
RefSeqi | NP_001027581.1, NM_001032409.2 [P00973-3] NP_001307080.1, NM_001320151.1 [P00973-4] NP_002525.2, NM_002534.3 [P00973-2] NP_058132.2, NM_016816.3 [P00973-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4IG8 | X-ray | 2.70 | A | 1-347 | [»] | |
SMRi | P00973 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110992, 16 interactors |
IntActi | P00973, 15 interactors |
MINTi | P00973 |
STRINGi | 9606.ENSP00000388001 |
Chemistry databases
DrugBanki | DB02987, Cysteine-S-acetamide |
PTM databases
iPTMneti | P00973 |
PhosphoSitePlusi | P00973 |
Genetic variation databases
BioMutai | OAS1 |
DMDMi | 296439492 |
Proteomic databases
EPDi | P00973 |
jPOSTi | P00973 |
MassIVEi | P00973 |
MaxQBi | P00973 |
PaxDbi | P00973 |
PeptideAtlasi | P00973 |
PRIDEi | P00973 |
ProteomicsDBi | 29167 51294 [P00973-1] 51295 [P00973-2] 51296 [P00973-3] 51297 [P00973-4] |
Protocols and materials databases
Antibodypediai | 1275, 330 antibodies from 34 providers |
DNASUi | 4938 |
Genome annotation databases
Ensembli | ENST00000202917; ENSP00000202917; ENSG00000089127 ENST00000445409; ENSP00000388001; ENSG00000089127 [P00973-3] ENST00000452357; ENSP00000415721; ENSG00000089127 [P00973-2] ENST00000551241; ENSP00000448790; ENSG00000089127 [P00973-4] ENST00000680189; ENSP00000505572; ENSG00000089127 ENST00000681934; ENSP00000505482; ENSG00000089127 |
GeneIDi | 4938 |
KEGGi | hsa:4938 |
MANE-Selecti | ENST00000202917.10; ENSP00000202917.5; NM_016816.4; NP_058132.2 |
UCSCi | uc001tub.4, human [P00973-1] |
Organism-specific databases
CTDi | 4938 |
DisGeNETi | 4938 |
GeneCardsi | OAS1 |
HGNCi | HGNC:8086, OAS1 |
HPAi | ENSG00000089127, Tissue enhanced (salivary gland, urinary bladder) |
MalaCardsi | OAS1 |
MIMi | 164350, gene |
neXtProti | NX_P00973 |
OpenTargetsi | ENSG00000089127 |
Orphaneti | 572428, Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia |
PharmGKBi | PA31875 |
VEuPathDBi | HostDB:ENSG00000089127 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RH25, Eukaryota KOG0001, Eukaryota COG5272, LUCA |
GeneTreei | ENSGT00510000046406 |
OMAi | HWYQKCK |
OrthoDBi | 866189at2759 |
PhylomeDBi | P00973 |
TreeFami | TF329749 |
Enzyme and pathway databases
BRENDAi | 2.7.7.84, 2681 |
PathwayCommonsi | P00973 |
Reactomei | R-HSA-877300, Interferon gamma signaling R-HSA-8983711, OAS antiviral response R-HSA-909733, Interferon alpha/beta signaling |
SABIO-RKi | P00973 |
SignaLinki | P00973 |
Miscellaneous databases
BioGRID-ORCSi | 4938, 7 hits in 1040 CRISPR screens |
ChiTaRSi | OAS1, human |
GeneWikii | OAS1 |
GenomeRNAii | 4938 |
Pharosi | P00973, Tbio |
PROi | PR:P00973 |
RNActi | P00973, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000089127, Expressed in ectocervix and 208 other tissues |
ExpressionAtlasi | P00973, baseline and differential |
Genevisiblei | P00973, HS |
Family and domain databases
CDDi | cd05400, NT_2-5OAS_ClassI-CCAase, 1 hit |
Gene3Di | 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR018952, 2-5-oligoAdlate_synth_1_dom2/C IPR026774, 2-5A_synthase IPR006117, 2-5OAS_C_CS IPR043518, 2-5OAS_N_CS IPR006116, NT_2-5OAS_ClassI-CCAase IPR043519, NT_sf IPR002934, Polymerase_NTP_transf_dom |
PANTHERi | PTHR11258, PTHR11258, 1 hit |
Pfami | View protein in Pfam PF01909, NTP_transf_2, 1 hit PF10421, OAS1_C, 1 hit |
SUPFAMi | SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS00832, 25A_SYNTH_1, 1 hit PS00833, 25A_SYNTH_2, 1 hit PS50152, 25A_SYNTH_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OAS1_HUMAN | |
Accessioni | P00973Primary (citable) accession number: P00973 Secondary accession number(s): A8K4N8 Q96J61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 219 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families