OAS1

Functionⁱ

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.4 Publications

Caution

PubMed:1651324 sequence was originally thought to originate from mouse.Curated

Catalytic activityⁱ

3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate.7 Publications

Cofactorⁱ

Mg²⁺1 Publication

Activity regulationⁱ

Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators.2 Publications

Kineticsⁱ

K_M=
0.31 mM for ATP
1 Publication
Manual assertion based on experiment inⁱ
- Ref.20
  "Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family."
  Eskildsen S., Justesen J., Schierup M.H., Hartmann R.
  Nucleic Acids Res. 31:3166-3173(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ACTIVITY REGULATION.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	63	ATP1 Publication	1
Metal bindingⁱ	75	Magnesium; catalytic	1
Metal bindingⁱ	77	Magnesium; catalytic	1
Metal bindingⁱ	148	Magnesium; catalytic	1
Binding siteⁱ	210	ATPBy similarity	1
Binding siteⁱ	213	ATP1 Publication	1
Binding siteⁱ	229	ATP1 Publication	1

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to interferon-alpha
Source: UniProtKB
Inferred from direct assayⁱ
- 3753689
defense response to virus
Source: UniProtKB
Inferred from direct assayⁱ
- 19923450
glucose homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23575436
glucose metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23575436
interferon-gamma-mediated signaling pathway Source: Reactome
negative regulation of viral genome replication
Source: UniProtKB
Inferred from direct assayⁱ
- 18931074
- 19923450
protein complex oligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 11682059
purine nucleotide biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 3753689
- 3754863
regulation of ribonuclease activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19923450
response to virus
Source: UniProtKB
Inferred from direct assayⁱ
- 18931074
type I interferon signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Nucleotidyltransferase, RNA-binding, Transferase
Biological process	Antiviral defense, Immunity, Innate immunity
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000089127-MONOMER
Reactomeⁱ	R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 2'-5'-oligoadenylate synthase 1 (EC:2.7.7.847 Publications) Short name: (2-5')oligo(A) synthase 1 Short name: 2-5A synthase 1 Alternative name(s): E18/E16 p46/p42 OAS
Gene namesⁱ	Name:OAS1 Synonyms:OIAS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000089127.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8086 OAS1
MIMⁱ	164350 gene
neXtProtⁱ	NX_P00973

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	66	K → A: Decreased enzyme activity. 1 Publication	1
Mutagenesisⁱ	75	D → A: Loss of activity; when associated with A-77. 2 Publications	1
Mutagenesisⁱ	77	D → A: Loss of activity; when associated with A-75. 2 Publications	1
Mutagenesisⁱ	148	D → A: Strongly reduced enzyme activity. 1 Publication	1
Mutagenesisⁱ	233	E → A: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	331	C → A: Loss of activity; when associated with A-332 and A-333. 1 Publication	1
Mutagenesisⁱ	332	F → A: Loss of activity; when associated with A-331 and A-333. 1 Publication	1
Mutagenesisⁱ	333	K → A: Loss of activity; when associated with A-331 and A-332. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4938
MalaCards human disease database More...MalaCardsⁱ	OAS1
Open Targets More...OpenTargetsⁱ	ENSG00000089127
Orphanetⁱ	264675 Hereditary pulmonary alveolar proteinosis
PharmGKBⁱ	PA31875

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02987 Cysteine-S-Acetamide

DrugBankⁱ

DB02987 Cysteine-S-Acetamide

Polymorphism and mutation databases

BioMutaⁱ	OAS1
DMDMⁱ	296439492

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000160259	1 – 400	2'-5'-oligoadenylate synthase 1Add BLAST		400

Proteomic databases

EPDⁱ	P00973
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P00973
PaxDbⁱ	P00973
PeptideAtlas More...PeptideAtlasⁱ	P00973
PRIDEⁱ	P00973
ProteomicsDBⁱ	51294 51295 [P00973-2] 51296 [P00973-3] 51297 [P00973-4]

PTM databases

iPTMnetⁱ	P00973
PhosphoSitePlusⁱ	P00973

Expressionⁱ

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000089127 Expressed in 191 organ(s), highest expression level in ectocervix
ExpressionAtlasⁱ	P00973 baseline and differential
Genevisibleⁱ	P00973 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB021104 HPA003657

HPAⁱ

CAB021104
HPA003657

Interactionⁱ

Subunit structureⁱ

Monomer (PubMed:9407111). Homotetramer (PubMed:9407111, PubMed:23319625).2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	158	Interaction with dsRNA		1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACTN1	P12814	3	EBI-3932815,EBI-351710
EXOC5	O00471	5	EBI-12081862,EBI-949824
PRMT6	Q96LA8	2	EBI-3932815,EBI-912440
TRIM27	P14373	5	EBI-12081862,EBI-719493

Protein-protein interaction databases

BioGridⁱ	110992, 7 interactors
IntActⁱ	P00973, 14 interactors
Molecular INTeraction database More...MINTⁱ	P00973
STRINGⁱ	9606.ENSP00000388001

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	4 – 6	Combined sources	3
Helixⁱ	9 – 11	Combined sources	3
Helixⁱ	12 – 19	Combined sources	8
Helixⁱ	24 – 43	Combined sources	20
Turnⁱ	44 – 46	Combined sources	3
Beta strandⁱ	55 – 61	Combined sources	7
Helixⁱ	62 – 66	Combined sources	5
Turnⁱ	71 – 73	Combined sources	3
Beta strandⁱ	76 – 84	Combined sources	9
Helixⁱ	88 – 111	Combined sources	24
Turnⁱ	112 – 114	Combined sources	3
Beta strandⁱ	116 – 118	Combined sources	3
Beta strandⁱ	132 – 137	Combined sources	6
Turnⁱ	139 – 141	Combined sources	3
Beta strandⁱ	145 – 152	Combined sources	8
Beta strandⁱ	161 – 163	Combined sources	3
Helixⁱ	167 – 179	Combined sources	13
Turnⁱ	183 – 186	Combined sources	4
Helixⁱ	187 – 190	Combined sources	4
Helixⁱ	191 – 195	Combined sources	5
Turnⁱ	196 – 200	Combined sources	5
Helixⁱ	203 – 223	Combined sources	21
Helixⁱ	229 – 243	Combined sources	15
Helixⁱ	251 – 263	Combined sources	13
Helixⁱ	265 – 267	Combined sources	3
Beta strandⁱ	278 – 280	Combined sources	3
Helixⁱ	281 – 290	Combined sources	10
Beta strandⁱ	293 – 295	Combined sources	3
Beta strandⁱ	297 – 300	Combined sources	4
Beta strandⁱ	303 – 308	Combined sources	6
Helixⁱ	313 – 326	Combined sources	14
Helixⁱ	330 – 332	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P00973
SMRⁱ	P00973
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	13 – 60	Interaction with dsRNAAdd BLAST		48
Regionⁱ	200 – 210	Interaction with dsRNAAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the 2-5A synthase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0001 Eukaryota COG5272 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046406
HOVERGENⁱ	HBG000994
KEGG Orthology (KO) More...KOⁱ	K14216
OMAⁱ	ENWTCTI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0160
PhylomeDBⁱ	P00973
TreeFamⁱ	TF329749

Family and domain databases

Gene3Dⁱ	1.10.1410.20, 1 hit
InterProⁱ	View protein in InterPro IPR006117 2-5-oligoadenylate_synth_CS IPR006116 2-5-oligoadenylate_synth_N IPR018952 2-5-oligoAdlate_synth_1_dom2/C IPR038121 2-5-oligoAdlate_synth_2_sf IPR026774 2-5A_synthase IPR002934 Polymerase_NTP_transf_dom
PANTHERⁱ	PTHR11258 PTHR11258, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01909 NTP_transf_2, 1 hit PF10421 OAS1_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00832 25A_SYNTH_1, 1 hit PS00833 25A_SYNTH_2, 1 hit PS50152 25A_SYNTH_3, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform p46 (identifier: P00973-1) [UniParc]FASTA Add to basket

Also known as: 46 kDa, E18

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS 
        60         70         80         90        100
YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ 
       110        120        130        140        150
EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL 
       160        170        180        190        200
PAFDALGQLT GGYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ 
       210        220        230        240        250
RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN 
       260        270        280        290        300
TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD 
       310        320        330        340        350
PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLAESN 
       360        370        380        390        400
SADDETDDPR RYQKYGYIGT HEYPHFSHRP STLQAASTPQ AEEDWTCTIL

Length:400

Mass (Da):46,029

Last modified:May 18, 2010 - v4

Checksum:ⁱ03F0A3AA17DAD4E4

GO

Isoform p41 (identifier: P00973-2) [UniParc]FASTA Add to basket

Also known as: 41 kDa, E16, 3-9

The sequence of this isoform differs from the canonical sequence as follows:
347-364: AESNSADDETDDPRRYQK → VRPPASSLPFIPAPLHEA
365-400: Missing.

« Hide

        10         20         30         40         50
MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS 
        60         70         80         90        100
YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ 
       110        120        130        140        150
EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL 
       160        170        180        190        200
PAFDALGQLT GGYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ 
       210        220        230        240        250
RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN 
       260        270        280        290        300
TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD 
       310        320        330        340        350
PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLVRPP 
       360 
ASSLPFIPAP LHEA

Show »

Length:364

Mass (Da):41,740

Checksum:ⁱ2FC9CA8944EC5901

GO

Isoform p48 (identifier: P00973-3) [UniParc]FASTA Add to basket

Also known as: 9-2

The sequence of this isoform differs from the canonical sequence as follows:
347-400: AESNSADDET...AEEDWTCTIL → TQHTPGSIHP...CIIQDRTQVS

« Hide

        10         20         30         40         50
MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS 
        60         70         80         90        100
YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ 
       110        120        130        140        150
EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL 
       160        170        180        190        200
PAFDALGQLT GGYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ 
       210        220        230        240        250
RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN 
       260        270        280        290        300
TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD 
       310        320        330        340        350
PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLTQHT 
       360        370        380        390        400
PGSIHPTGRR GLDLHHPLNA SASWGKGLQC YLDQFLHFQV GLLIQRGQSS 
       410 
SVSWCIIQDR TQVS

Show »

Length:414

Mass (Da):47,408

Checksum:ⁱE17B28ECAE185399

GO

Isoform p44 (identifier: P00973-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
347-382: AESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPST → VNLTLVGRRNYPIISEHAVNLQQTRRASLSYSFQVA
383-400: Missing.

« Hide

        10         20         30         40         50
MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS 
        60         70         80         90        100
YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ 
       110        120        130        140        150
EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL 
       160        170        180        190        200
PAFDALGQLT GGYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ 
       210        220        230        240        250
RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN 
       260        270        280        290        300
TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD 
       310        320        330        340        350
PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLVNLT 
       360        370        380 
LVGRRNYPII SEHAVNLQQT RRASLSYSFQ VA

Show »

Length:382

Mass (Da):43,944

Checksum:ⁱ89654CF4DFFD195C

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VXY3	F8VXY3_HUMAN	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 1	OAS1	360	Annotation score:
H0YI20	H0YI20_HUMAN	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 1	OAS1	302	Annotation score:
F8VUC8	F8VUC8_HUMAN	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 1	OAS1	177	Annotation score:
H0YIB8	H0YIB8_HUMAN	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 1	OAS1	130	Annotation score:
F8VPW7	F8VPW7_HUMAN	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 1	OAS1	83	Annotation score:
C6EMZ7	C6EMZ7_HUMAN	2'-5' oligoadenylate synthetase 1 p... 2'-5' oligoadenylate synthetase 1 p41 isoform (2'-5'-oligoadenylate synthase 1)	OAS1	15	Annotation score:
S4R3A5	S4R3A5_HUMAN	2'-5'-oligoadenylate synthase 1 2'-5'-oligoadenylate synthase 1	OAS1	22	Annotation score:

Sequence cautionⁱ

The sequence AAA39857 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAA39858 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAA59955 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAD96726 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA26497 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAA30164 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	18	D → E in AAA39857 (PubMed:1651324).Curated	1
Sequence conflictⁱ	111	R → S in AAH71981 (PubMed:15489334).Curated	1
Sequence conflictⁱ	115	F → L in AAB59552 (PubMed:2416561).Curated	1
Sequence conflictⁱ	115	F → L in AAB59553 (PubMed:2416561).Curated	1
Sequence conflictⁱ	115	F → L in CAA26633 (PubMed:2416561).Curated	1
Sequence conflictⁱ	120	E → V in BAD96726 (Ref. 10) Curated	1
Sequence conflictⁱ	122	Q → QE in AAA39858 (PubMed:1651324).Curated	1
Sequence conflictⁱ	157	G → D in AAA39857 (PubMed:1651324).Curated	1
Sequence conflictⁱ	176	E → D in AAA39858 (PubMed:1651324).Curated	1
Sequence conflictⁱ	295	R → T in CAB51602 (PubMed:3753689).Curated	1
Sequence conflictⁱ	315	G → R in CAB51602 (PubMed:3753689).Curated	1
Isoform p48 (identifier: P00973-3)
Sequence conflictⁱ	397	G → R in AAA39858 (PubMed:1651324).Curated	1
Sequence conflictⁱ	397	G → R in AAW63050 (PubMed:17024523).Curated	1
Sequence conflictⁱ	397	G → R in CAA26497 (PubMed:2411547).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_060471	31	N → D1 PublicationCorresponds to variant dbSNP:rs1050994Ensembl.	1
Natural variantⁱVAR_060472	127	G → R. Corresponds to variant dbSNP:rs4767022Ensembl.	1
Natural variantⁱVAR_034872	162	G → S9 PublicationsCorresponds to variant dbSNP:rs1131454EnsemblClinVar.	1
Natural variantⁱVAR_060473	352	A → T3 PublicationsCorresponds to variant dbSNP:rs1131476Ensembl.	1
Natural variantⁱVAR_057658	354	D → G. Corresponds to variant dbSNP:rs35919998Ensembl.	1
Natural variantⁱVAR_057659	361	R → T3 PublicationsCorresponds to variant dbSNP:rs1051042Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_003740	347 – 400	AESNS…TCTIL → TQHTPGSIHPTGRRGLDLHH PLNASASWGKGLQCYLDQFL HFQVGLLIQRGQSSSVSWCI IQDRTQVS in isoform p48. 2 PublicationsAdd BLAST	54
Alternative sequenceⁱVSP_027804	347 – 382	AESNS…HRPST → VNLTLVGRRNYPIISEHAVN LQQTRRASLSYSFQVA in isoform p44. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_003738	347 – 364	AESNS…RRYQK → VRPPASSLPFIPAPLHEA in isoform p41. 8 PublicationsAdd BLAST	18
Alternative sequenceⁱVSP_003739	365 – 400	Missing in isoform p41. 8 PublicationsAdd BLAST	36
Alternative sequenceⁱVSP_027805	383 – 400	Missing in isoform p44. 1 PublicationAdd BLAST	18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11809 , M11805, M11806, M11807, M11808 Genomic DNA Translation: AAB59552.1 M11810 Genomic DNA Translation: AAB59553.1 X02874 mRNA Translation: CAA26633.1 X02875 mRNA Translation: CAA26634.1 X04371 mRNA Translation: CAB51602.1 D00068 mRNA Translation: BAA00047.1 M63849 Genomic DNA Translation: AAA39857.1 Different initiation. M63850 Genomic DNA Translation: AAA39858.1 Different initiation. AJ629455 mRNA Translation: CAF33358.1 AY730628 mRNA Translation: AAW63050.1 DQ445949 Genomic DNA Translation: ABE27977.1 AK291003 mRNA Translation: BAF83692.1 BT006785 mRNA Translation: AAP35431.1 AK223006 mRNA Translation: BAD96726.1 Different initiation. AC004551 Genomic DNA No translation available. BC000562 mRNA Translation: AAH00562.4 BC061587 mRNA Translation: AAH61587.1 BC071981 mRNA Translation: AAH71981.3 X06560 Genomic DNA Translation: CAA29803.1 M18099 Genomic DNA Translation: AAA59955.1 Different initiation. X07179 Genomic DNA Translation: CAA30164.1 Different initiation. X02661 mRNA Translation: CAA26497.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31905.1 [P00973-3] CCDS41838.1 [P00973-1] CCDS44980.1 [P00973-2]
PIRⁱ	A39417 SYMSO2 A91013 SYHU16 B24359 SYHU18 B39417 SYMSO3
NCBI Reference Sequences More...RefSeqⁱ	NP_001027581.1, NM_001032409.2 [P00973-3] NP_001307080.1, NM_001320151.1 NP_002525.2, NM_002534.3 [P00973-2] NP_058132.2, NM_016816.3 [P00973-1]
UniGeneⁱ	Hs.524760

Genome annotation databases

Ensemblⁱ	ENST00000202917; ENSP00000202917; ENSG00000089127 [P00973-1] ENST00000445409; ENSP00000388001; ENSG00000089127 [P00973-3] ENST00000452357; ENSP00000415721; ENSG00000089127 [P00973-2]
GeneIDⁱ	4938
KEGGⁱ	hsa:4938
UCSC genome browser More...UCSCⁱ	uc001tub.4 human [P00973-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P00973	2'-5' oligoadenylate synthetase 1 p41 isoform (Fragment)		HUMAN		15	UniRef100_P00973

Protein	Similar proteins		Species	Score	Length	Source
P00973	2'-5' oligoadenylate synthetase 1 p41 isoform (Fragment)		HUMAN		15	UniRef90_P00973
Uncharacterized protein		PAPAN		488
Uncharacterized protein		MACFA		488
Uncharacterized protein		MACNE		488
Uncharacterized protein		PONAB		457
+44
P00973-2	Uncharacterized protein		NOMLE		372	UniRef90_P00973-2
Oligoadenylate synthetase 1		PANPA		365
Oligoadenylate synthetase 1		Pan troglodytes troglodytes		365
2'-5' oligoadenylate synthetase 1 (Fragment)		PAPAN		364
2'-5'-oligoadenylate synthetase 1		PANTR		360
+20
P00973-3	OAS1 isoform 4		PONAB		414	UniRef90_P00973-3
2'-5'-oligoadenylate synthetase 1		GORGO		414
UPI0002746EFC		PANPA		415
UPI000CEFE723		PONAB		471
P00973-4	2'-5' oligoadenylate synthetase 1 p52 isoform		HUMAN		459	UniRef90_P00973-4
2'-5'-oligoadenylate synthetase 1		PANTR		442
Uncharacterized protein		PANPA		372
2'-5'-oligoadenylate synthetase 1		GORGO		371
Truncated 2'-5' oligoadenylate synthetase		HUMAN		46
+2

Protein	Similar proteins		Species	Score	Length	Source
P00973	2'-5'-oligoadenylate synthase 1A		MOUSE		367	UniRef50_P00973
2'-5' oligoadenylate synthetase 1 p41 isoform (Fragment)		HUMAN		15
Uncharacterized protein		MACNE		488
Uncharacterized protein		PAPAN		488
Uncharacterized protein		MACFA		488
+223

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11809 , M11805, M11806, M11807, M11808 Genomic DNA Translation: AAB59552.1 M11810 Genomic DNA Translation: AAB59553.1 X02874 mRNA Translation: CAA26633.1 X02875 mRNA Translation: CAA26634.1 X04371 mRNA Translation: CAB51602.1 D00068 mRNA Translation: BAA00047.1 M63849 Genomic DNA Translation: AAA39857.1 Different initiation. M63850 Genomic DNA Translation: AAA39858.1 Different initiation. AJ629455 mRNA Translation: CAF33358.1 AY730628 mRNA Translation: AAW63050.1 DQ445949 Genomic DNA Translation: ABE27977.1 AK291003 mRNA Translation: BAF83692.1 BT006785 mRNA Translation: AAP35431.1 AK223006 mRNA Translation: BAD96726.1 Different initiation. AC004551 Genomic DNA No translation available. BC000562 mRNA Translation: AAH00562.4 BC061587 mRNA Translation: AAH61587.1 BC071981 mRNA Translation: AAH71981.3 X06560 Genomic DNA Translation: CAA29803.1 M18099 Genomic DNA Translation: AAA59955.1 Different initiation. X07179 Genomic DNA Translation: CAA30164.1 Different initiation. X02661 mRNA Translation: CAA26497.1 Sequence problems.
CCDSⁱ	CCDS31905.1 [P00973-3] CCDS41838.1 [P00973-1] CCDS44980.1 [P00973-2]
PIRⁱ	A39417 SYMSO2 A91013 SYHU16 B24359 SYHU18 B39417 SYMSO3
RefSeqⁱ	NP_001027581.1, NM_001032409.2 [P00973-3] NP_001307080.1, NM_001320151.1 NP_002525.2, NM_002534.3 [P00973-2] NP_058132.2, NM_016816.3 [P00973-1]
UniGeneⁱ	Hs.524760

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4IG8	X-ray	2.70	A	1-347	[»]
ProteinModelPortalⁱ	P00973
SMRⁱ	P00973
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110992, 7 interactors
IntActⁱ	P00973, 14 interactors
MINTⁱ	P00973
STRINGⁱ	9606.ENSP00000388001

Chemistry databases

DrugBankⁱ	DB02987 Cysteine-S-Acetamide

DrugBankⁱ

DB02987 Cysteine-S-Acetamide

PTM databases

iPTMnetⁱ	P00973
PhosphoSitePlusⁱ	P00973

Polymorphism and mutation databases

BioMutaⁱ	OAS1
DMDMⁱ	296439492

Proteomic databases

EPDⁱ	P00973
MaxQBⁱ	P00973
PaxDbⁱ	P00973
PeptideAtlasⁱ	P00973
PRIDEⁱ	P00973
ProteomicsDBⁱ	51294 51295 [P00973-2] 51296 [P00973-3] 51297 [P00973-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4938
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000202917; ENSP00000202917; ENSG00000089127 [P00973-1] ENST00000445409; ENSP00000388001; ENSG00000089127 [P00973-3] ENST00000452357; ENSP00000415721; ENSG00000089127 [P00973-2]
GeneIDⁱ	4938
KEGGⁱ	hsa:4938
UCSCⁱ	uc001tub.4 human [P00973-1]

Organism-specific databases

CTDⁱ	4938
DisGeNETⁱ	4938
EuPathDBⁱ	HostDB:ENSG00000089127.12
GeneCardsⁱ	OAS1
HGNCⁱ	HGNC:8086 OAS1
HPAⁱ	CAB021104 HPA003657
MalaCardsⁱ	OAS1
MIMⁱ	164350 gene
neXtProtⁱ	NX_P00973
OpenTargetsⁱ	ENSG00000089127
Orphanetⁱ	264675 Hereditary pulmonary alveolar proteinosis
PharmGKBⁱ	PA31875
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0001 Eukaryota COG5272 LUCA
GeneTreeⁱ	ENSGT00510000046406
HOVERGENⁱ	HBG000994
KOⁱ	K14216
OMAⁱ	ENWTCTI
OrthoDBⁱ	EOG091G0160
PhylomeDBⁱ	P00973
TreeFamⁱ	TF329749

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000089127-MONOMER
Reactomeⁱ	R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling

Miscellaneous databases

ChiTaRSⁱ	OAS1 human
GeneWikiⁱ	OAS1
GenomeRNAiⁱ	4938
Protein Ontology More...PROⁱ	PR:P00973
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000089127 Expressed in 191 organ(s), highest expression level in ectocervix
ExpressionAtlasⁱ	P00973 baseline and differential
Genevisibleⁱ	P00973 HS

Family and domain databases

Gene3Dⁱ	1.10.1410.20, 1 hit
InterProⁱ	View protein in InterPro IPR006117 2-5-oligoadenylate_synth_CS IPR006116 2-5-oligoadenylate_synth_N IPR018952 2-5-oligoAdlate_synth_1_dom2/C IPR038121 2-5-oligoAdlate_synth_2_sf IPR026774 2-5A_synthase IPR002934 Polymerase_NTP_transf_dom
PANTHERⁱ	PTHR11258 PTHR11258, 1 hit
Pfamⁱ	View protein in Pfam PF01909 NTP_transf_2, 1 hit PF10421 OAS1_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00832 25A_SYNTH_1, 1 hit PS00833 25A_SYNTH_2, 1 hit PS50152 25A_SYNTH_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OAS1_HUMAN
Accessionⁱ	P00973Primary (citable) accession number: P00973 Secondary accession number(s): A8K4N8 Q96J61
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - P00973 (OAS1_HUMAN)

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2'-5'-oligoadenylate synthase 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endoplasmic reticulum

Extracellular region or secreted

Mitochondrion

Other locations

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ