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UniProtKB - P00973 (OAS1_HUMAN)

Entry version 219 (23 Feb 2022)
Sequence version 4 (18 May 2010)
Previous versions | rss
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Protein

2'-5'-oligoadenylate synthase 1

Gene

OAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622).

In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34581622).

Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

5 Publications

When prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target (PubMed:34581622).

The same mechanism is necessary to initiate a block to cardiovirus EMCV (PubMed:34581622).

1 Publication

Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.

1 Publication

Caution

PubMed:1651324 sequence was originally thought to originate from mouse.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated (PubMed:34581622). ssRNA or dsDNA do not act as activators.3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.31 mM for ATP1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63ATPCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi75Magnesium; catalyticCombined sources1 Publication1
Metal bindingi77Magnesium; catalyticCombined sources1 Publication1
Metal bindingi148Magnesium; catalyticCombined sources1 Publication1
Binding sitei210ATPBy similarity1
Binding sitei213ATPCombined sources1 Publication1
Binding sitei229ATPCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
Biological processAntiviral defense, Immunity, Innate immunity
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.7.84, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P00973

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-877300, Interferon gamma signaling
R-HSA-8983711, OAS antiviral response
R-HSA-909733, Interferon alpha/beta signaling

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P00973

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P00973

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2'-5'-oligoadenylate synthase 1 (EC:2.7.7.847 Publications)
Short name:
(2-5')oligo(A) synthase 1
Short name:
2-5A synthase 1
Alternative name(s):
E18/E16
p46/p42 OAS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OAS1
Synonyms:OIAS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8086, OAS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164350, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P00973

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000089127

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Mitochondrion, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi66K → A: Decreased enzyme activity. 1 Publication1
Mutagenesisi75D → A: Loss of activity; when associated with A-77. 2 Publications1
Mutagenesisi77D → A: Loss of activity; when associated with A-75. 2 Publications1
Mutagenesisi148D → A: Strongly reduced enzyme activity. 1 Publication1
Mutagenesisi233E → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi331C → A: Loss of activity; when associated with A-332 and A-333. 1 Publication1
Mutagenesisi332F → A: Loss of activity; when associated with A-331 and A-333. 1 Publication1
Mutagenesisi333K → A: Loss of activity; when associated with A-331 and A-332. 1 Publication1
Mutagenesisi397C → A: Not prenylated and diffusely distributed. Loss of antiviral activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4938

MalaCards human disease database

More...MalaCardsi		OAS1

Open Targets

More...OpenTargetsi		ENSG00000089127

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		572428, Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31875

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P00973, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02987, Cysteine-S-acetamide

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		OAS1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439492

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001602591 – 4002'-5'-oligoadenylate synthase 1Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi397S-geranylgeranyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prenylated at C-terminal. C-terminal prenylation is necessary to initiate a block to SARS-CoV-2 and is associated with protection from severe COVID-1. The prenylated form is targeted to perinuclear structures rich in viral dsRNA, whereas the non-prenylated form is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication (Probable). C-terminal prenylation is also necessary to initiate a block to cardiovirus EMCV (Probable).1 Publication
Not prenylated at C-terminal. The non-prenylated form is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.1 Publication

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P00973

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P00973

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P00973

MaxQB - The MaxQuant DataBase

More...MaxQBi		P00973

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P00973

PeptideAtlas

More...PeptideAtlasi		P00973

PRoteomics IDEntifications database

More...PRIDEi		P00973

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		29167
51294 [P00973-1]
51295 [P00973-2]
51296 [P00973-3]
51297 [P00973-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P00973

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P00973

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lungs.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By type I interferon (IFN) and viruses.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000089127, Expressed in ectocervix and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P00973, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P00973, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000089127, Tissue enhanced (salivary gland, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:9407111). Homotetramer (PubMed:9407111, PubMed:23319625).

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei158Interaction with dsRNACombined sources1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110992, 16 interactors

Protein interaction database and analysis system

More...IntActi		P00973, 15 interactors

Molecular INTeraction database

More...MINTi		P00973

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000388001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P00973, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P00973

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 60Interaction with dsRNACombined sources1 PublicationAdd BLAST48
Regioni200 – 210Interaction with dsRNACombined sources1 PublicationAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 2-5A synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RH25, Eukaryota
KOG0001, Eukaryota
COG5272, LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00510000046406

Identification of Orthologs from Complete Genome Data

More...OMAi		HWYQKCK

Database of Orthologous Groups

More...OrthoDBi		866189at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P00973

TreeFam database of animal gene trees

More...TreeFami		TF329749

Family and domain databases

Conserved Domains Database

More...CDDi		cd05400, NT_2-5OAS_ClassI-CCAase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018952, 2-5-oligoAdlate_synth_1_dom2/C
IPR026774, 2-5A_synthase
IPR006117, 2-5OAS_C_CS
IPR043518, 2-5OAS_N_CS
IPR006116, NT_2-5OAS_ClassI-CCAase
IPR043519, NT_sf
IPR002934, Polymerase_NTP_transf_dom

The PANTHER Classification System

More...PANTHERi		PTHR11258, PTHR11258, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01909, NTP_transf_2, 1 hit
PF10421, OAS1_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81301, SSF81301, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00832, 25A_SYNTH_1, 1 hit
PS00833, 25A_SYNTH_2, 1 hit
PS50152, 25A_SYNTH_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform p462 Publications (identifier: P00973-1) [UniParc]FASTAAdd to basket
Also known as: 46 kDa, E18

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS 
        60         70         80         90        100
YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ 
       110        120        130        140        150
EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL 
       160        170        180        190        200
PAFDALGQLT GGYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ 
       210        220        230        240        250
RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN 
       260        270        280        290        300
TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD 
       310        320        330        340        350
PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLAESN 
       360        370        380        390        400
SADDETDDPR RYQKYGYIGT HEYPHFSHRP STLQAASTPQ AEEDWTCTIL
Length:400
Mass (Da):46,029
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03F0A3AA17DAD4E4
GO
Isoform p422 Publications (identifier: P00973-2) [UniParc]FASTAAdd to basket
Also known as: 41 kDa, E16, 3-9, p41

The sequence of this isoform differs from the canonical sequence as follows:
     347-364: AESNSADDETDDPRRYQK → VRPPASSLPFIPAPLHEA
     365-400: Missing.

Show »
Length:364
Mass (Da):41,740
Checksum:i2FC9CA8944EC5901
GO
Isoform p48 (identifier: P00973-3) [UniParc]FASTAAdd to basket
Also known as: 9-2

The sequence of this isoform differs from the canonical sequence as follows:
     347-400: AESNSADDET...AEEDWTCTIL → TQHTPGSIHP...CIIQDRTQVS

Show »
Length:414
Mass (Da):47,408
Checksum:iE17B28ECAE185399
GO
Isoform p44 (identifier: P00973-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-360: AESNSADDETDDPR → VNLTLVGRRNYTNN
     361-400: Missing.

Show »
Length:360
Mass (Da):41,475
Checksum:iB79AB3D508B92A5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6Q8PHR1A0A6Q8PHR1_HUMAN
2'-5' oligoadenylate synthase
OAS1
356Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIB8H0YIB8_HUMAN
2'-5' oligoadenylate synthase
OAS1
384Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3A5S4R3A5_HUMAN
2'-5' oligoadenylate synthase
OAS1
403Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R467S4R467_HUMAN
2'-5' oligoadenylate synthase
OAS1
361Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0Z4N8A0A7P0Z4N8_HUMAN
2'-5' oligoadenylate synthase
OAS1
392Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T854A0A7P0T854_HUMAN
2'-5' oligoadenylate synthase
OAS1
353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T879A0A7P0T879_HUMAN
2'-5' oligoadenylate synthase
OAS1
407Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TBG0A0A7P0TBG0_HUMAN
2'-5' oligoadenylate synthase
OAS1
405Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPW7F8VPW7_HUMAN
2'-5'-oligoadenylate synthase 1
OAS1
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8E1A0A7P0T8E1_HUMAN
2'-5'-oligoadenylate synthase 1
OAS1
408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA39857 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA39858 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA59955 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD96726 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA26497 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA30164 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAF33358 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18D → E in AAA39857 (PubMed:1651324).Curated1
Sequence conflicti111R → S in AAH71981 (PubMed:15489334).Curated1
Sequence conflicti115F → L in AAB59552 (PubMed:2416561).Curated1
Sequence conflicti115F → L in AAB59553 (PubMed:2416561).Curated1
Sequence conflicti115F → L in CAA26633 (PubMed:2416561).Curated1
Sequence conflicti120E → V in BAD96726 (Ref. 10) Curated1
Sequence conflicti122Q → QE in AAA39858 (PubMed:1651324).Curated1
Sequence conflicti157G → D in AAA39857 (PubMed:1651324).Curated1
Sequence conflicti176E → D in AAA39858 (PubMed:1651324).Curated1
Sequence conflicti295R → T in CAB51602 (PubMed:3753689).Curated1
Sequence conflicti315G → R in CAB51602 (PubMed:3753689).Curated1
Isoform p48 (identifier: P00973-3)
Sequence conflicti397G → R in AAA39858 (PubMed:1651324).Curated1
Sequence conflicti397G → R in AAW63050 (PubMed:17024523).Curated1
Sequence conflicti397G → R in CAA26497 (PubMed:2411547).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Polymorphism dbSNP:rs10774671 is associated with protection against severe COVID-19 disease (PubMed:34581622, PubMed:33633408). In humans, the OAS1 protein is expressed as two major forms designated p46 and p42. The longer p46 isoform is generated by alternative splicing to an exon downstream of the terminal exon used by the p42 isoform. Although all human genotypes contain the exon that completes the transcript encoding p46, an intronic SNP (rs10774671) determines OAS1 exon usage. Alleles with a G at this SNP (G alleles) specify expression of the p46 isoform and some p42, whereas alleles with A at this position predominantly encode the p42 isoform and cannot express the p46 isoform (PubMed:34581622). The p42 isoform, which is the most common isoform in humans (~61% of alleles), has no detectable anti-SARS-CoV-2 activity. The p46 isoform has anti-SARS-CoV-2 activity (PubMed:34581622).1 Publication1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06047131N → D1 PublicationCorresponds to variant dbSNP:rs1050994Ensembl.1
Natural variantiVAR_060472127G → R. Corresponds to variant dbSNP:rs4767022Ensembl.1
Natural variantiVAR_034872162G → S9 PublicationsCorresponds to variant dbSNP:rs1131454EnsemblClinVar.1
Natural variantiVAR_060473352A → T3 PublicationsCorresponds to variant dbSNP:rs1131476Ensembl.1
Natural variantiVAR_057658354D → G. Corresponds to variant dbSNP:rs35919998Ensembl.1
Natural variantiVAR_057659361R → T3 PublicationsCorresponds to variant dbSNP:rs1051042Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003740347 – 400AESNS…TCTIL → TQHTPGSIHPTGRRGLDLHH PLNASASWGKGLQCYLDQFL HFQVGLLIQRGQSSSVSWCI IQDRTQVS in isoform p48. 2 PublicationsAdd BLAST54
Alternative sequenceiVSP_003738347 – 364AESNS…RRYQK → VRPPASSLPFIPAPLHEA in isoform p42. 8 PublicationsAdd BLAST18
Alternative sequenceiVSP_060747347 – 360AESNS…TDDPR → VNLTLVGRRNYTNN in isoform p44. Add BLAST14
Alternative sequenceiVSP_060748361 – 400Missing in isoform p44. Add BLAST40
Alternative sequenceiVSP_003739365 – 400Missing in isoform p42. 8 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M11809 M11808 Genomic DNA Translation: AAB59552.1
M11810 Genomic DNA Translation: AAB59553.1
X02874 mRNA Translation: CAA26633.1
X02875 mRNA Translation: CAA26634.1
X04371 mRNA Translation: CAB51602.1
D00068 mRNA Translation: BAA00047.1
M63849 Genomic DNA Translation: AAA39857.1 Different initiation.
M63850 Genomic DNA Translation: AAA39858.1 Different initiation.
AJ629455 mRNA Translation: CAF33358.1 Frameshift.
AY730628 mRNA Translation: AAW63050.1
DQ445949 Genomic DNA Translation: ABE27977.1
AK291003 mRNA Translation: BAF83692.1
BT006785 mRNA Translation: AAP35431.1
AK223006 mRNA Translation: BAD96726.1 Different initiation.
AC004551 Genomic DNA No translation available.
BC000562 mRNA Translation: AAH00562.4
BC061587 mRNA Translation: AAH61587.1
BC071981 mRNA Translation: AAH71981.3
X06560 Genomic DNA Translation: CAA29803.1
M18099 Genomic DNA Translation: AAA59955.1 Different initiation.
X07179 Genomic DNA Translation: CAA30164.1 Different initiation.
X02661 mRNA Translation: CAA26497.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31905.1 [P00973-3]
CCDS41838.1 [P00973-1]
CCDS44980.1 [P00973-2]
CCDS81742.1 [P00973-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A39417, SYMSO2
A91013, SYHU16
B24359, SYHU18
B39417, SYMSO3

NCBI Reference Sequences

More...RefSeqi		NP_001027581.1, NM_001032409.2 [P00973-3]
NP_001307080.1, NM_001320151.1 [P00973-4]
NP_002525.2, NM_002534.3 [P00973-2]
NP_058132.2, NM_016816.3 [P00973-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000202917; ENSP00000202917; ENSG00000089127
ENST00000445409; ENSP00000388001; ENSG00000089127 [P00973-3]
ENST00000452357; ENSP00000415721; ENSG00000089127 [P00973-2]
ENST00000551241; ENSP00000448790; ENSG00000089127 [P00973-4]
ENST00000680189; ENSP00000505572; ENSG00000089127
ENST00000681934; ENSP00000505482; ENSG00000089127

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4938

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000202917.10; ENSP00000202917.5; NM_016816.4; NP_058132.2

UCSC genome browser

More...UCSCi		uc001tub.4, human [P00973-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11809 M11808 Genomic DNA Translation: AAB59552.1
M11810 Genomic DNA Translation: AAB59553.1
X02874 mRNA Translation: CAA26633.1
X02875 mRNA Translation: CAA26634.1
X04371 mRNA Translation: CAB51602.1
D00068 mRNA Translation: BAA00047.1
M63849 Genomic DNA Translation: AAA39857.1 Different initiation.
M63850 Genomic DNA Translation: AAA39858.1 Different initiation.
AJ629455 mRNA Translation: CAF33358.1 Frameshift.
AY730628 mRNA Translation: AAW63050.1
DQ445949 Genomic DNA Translation: ABE27977.1
AK291003 mRNA Translation: BAF83692.1
BT006785 mRNA Translation: AAP35431.1
AK223006 mRNA Translation: BAD96726.1 Different initiation.
AC004551 Genomic DNA No translation available.
BC000562 mRNA Translation: AAH00562.4
BC061587 mRNA Translation: AAH61587.1
BC071981 mRNA Translation: AAH71981.3
X06560 Genomic DNA Translation: CAA29803.1
M18099 Genomic DNA Translation: AAA59955.1 Different initiation.
X07179 Genomic DNA Translation: CAA30164.1 Different initiation.
X02661 mRNA Translation: CAA26497.1 Sequence problems.
CCDSiCCDS31905.1 [P00973-3]
CCDS41838.1 [P00973-1]
CCDS44980.1 [P00973-2]
CCDS81742.1 [P00973-4]
PIRiA39417, SYMSO2
A91013, SYHU16
B24359, SYHU18
B39417, SYMSO3
RefSeqiNP_001027581.1, NM_001032409.2 [P00973-3]
NP_001307080.1, NM_001320151.1 [P00973-4]
NP_002525.2, NM_002534.3 [P00973-2]
NP_058132.2, NM_016816.3 [P00973-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IG8X-ray2.70A1-347[»]
SMRiP00973
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110992, 16 interactors
IntActiP00973, 15 interactors
MINTiP00973
STRINGi9606.ENSP00000388001

Chemistry databases

DrugBankiDB02987, Cysteine-S-acetamide

PTM databases

iPTMnetiP00973
PhosphoSitePlusiP00973

Genetic variation databases

BioMutaiOAS1
DMDMi296439492

Proteomic databases

EPDiP00973
jPOSTiP00973
MassIVEiP00973
MaxQBiP00973
PaxDbiP00973
PeptideAtlasiP00973
PRIDEiP00973
ProteomicsDBi29167
51294 [P00973-1]
51295 [P00973-2]
51296 [P00973-3]
51297 [P00973-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1275, 330 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		4938

Genome annotation databases

EnsembliENST00000202917; ENSP00000202917; ENSG00000089127
ENST00000445409; ENSP00000388001; ENSG00000089127 [P00973-3]
ENST00000452357; ENSP00000415721; ENSG00000089127 [P00973-2]
ENST00000551241; ENSP00000448790; ENSG00000089127 [P00973-4]
ENST00000680189; ENSP00000505572; ENSG00000089127
ENST00000681934; ENSP00000505482; ENSG00000089127
GeneIDi4938
KEGGihsa:4938
MANE-SelectiENST00000202917.10; ENSP00000202917.5; NM_016816.4; NP_058132.2
UCSCiuc001tub.4, human [P00973-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4938
DisGeNETi4938

GeneCards: human genes, protein and diseases

More...GeneCardsi		OAS1
HGNCiHGNC:8086, OAS1
HPAiENSG00000089127, Tissue enhanced (salivary gland, urinary bladder)
MalaCardsiOAS1
MIMi164350, gene
neXtProtiNX_P00973
OpenTargetsiENSG00000089127
Orphaneti572428, Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia
PharmGKBiPA31875
VEuPathDBiHostDB:ENSG00000089127

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RH25, Eukaryota
KOG0001, Eukaryota
COG5272, LUCA
GeneTreeiENSGT00510000046406
OMAiHWYQKCK
OrthoDBi866189at2759
PhylomeDBiP00973
TreeFamiTF329749

Enzyme and pathway databases

BRENDAi2.7.7.84, 2681
PathwayCommonsiP00973
ReactomeiR-HSA-877300, Interferon gamma signaling
R-HSA-8983711, OAS antiviral response
R-HSA-909733, Interferon alpha/beta signaling
SABIO-RKiP00973
SignaLinkiP00973

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4938, 7 hits in 1040 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		OAS1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		OAS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4938
PharosiP00973, Tbio

Protein Ontology

More...PROi		PR:P00973
RNActiP00973, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000089127, Expressed in ectocervix and 208 other tissues
ExpressionAtlasiP00973, baseline and differential
GenevisibleiP00973, HS

Family and domain databases

CDDicd05400, NT_2-5OAS_ClassI-CCAase, 1 hit
Gene3Di3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR018952, 2-5-oligoAdlate_synth_1_dom2/C
IPR026774, 2-5A_synthase
IPR006117, 2-5OAS_C_CS
IPR043518, 2-5OAS_N_CS
IPR006116, NT_2-5OAS_ClassI-CCAase
IPR043519, NT_sf
IPR002934, Polymerase_NTP_transf_dom
PANTHERiPTHR11258, PTHR11258, 1 hit
PfamiView protein in Pfam
PF01909, NTP_transf_2, 1 hit
PF10421, OAS1_C, 1 hit
SUPFAMiSSF81301, SSF81301, 1 hit
PROSITEiView protein in PROSITE
PS00832, 25A_SYNTH_1, 1 hit
PS00833, 25A_SYNTH_2, 1 hit
PS50152, 25A_SYNTH_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOAS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P00973
Secondary accession number(s): A8K4N8
, F8VXY3, P04820, P29080, P29081, P78485, P78486, Q16700, Q16701, Q1PG42, Q3ZM01, Q53GC5, Q53YA4, Q6A1Z3, Q6IPC6, Q6P7N9, Q96J61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 18, 2010
Last modified: February 23, 2022
This is version 219 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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